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15793134,29040909,16623857,30290285,15793138,26862474,30082291,21249304,2117856,27215760,22975280,31978394,23529066,29267280,30240395,17395432,22570424,17485457,20452188,32416214,28225900,20128813,9588585,33305846,27161638,26350447,17698625,18625779,19254164,24827034,28011170,26323937,26341064,20027472,32844906,12965912,29311242,9057760,8937280,29448038,8030049,22890036,25707979,16085036,25940197,28720491,16702588,15844009,32274510,12387906,27158908,21609270,17220408,21773664,30301480,10837436,23130989,32366719,27729250,18454349,19753491,16702585,26076455,29281643,29569658,25744336,20479201,23107306,15855522,17638698,18585495,29452113,11685270,22898619,29750791,19747482,31365537,17339569,10881079,35138142,23274812,18570370,24675024,29305891,12937719,15821788,33168611,26236582,19854145,11746849,34280400,17286971,9661307,28231946,31353153,33400707,12653687,26407938,27001816,18455041,23964077,18823980,22161779,10395865,31669531,26014936,30625275,26596935,21371583,20433834,27619190,26239982,27067322,36972298,32652140,2121842,28645201,10602737,19127950,27993857,10887376,27376642,35101415,25993507,9790423,16937919,30383777,26747009,32194558,35942849,32369594,32970692,12171581,31307503,16185616,19582142,8273735,8579025,25284065,30916205,33547365,33857596,12193101,22037851,24465654,27073267,31740423,21120371,33298212,19448942,26169419,34784372,30133646,20457822,20823286,31358581,7995998,25617628,34381739,30868539,12806455,25467275,35772309,25742267,28001218,3130683,29352704,36530434,22574131,25912691,20440625,9148337,31610148,21814568,30712757,12880590,9509026,11484850,33347472,36173378,10594562,12887027,17603548,26760095,26760094,26760093,26760092,10090596,27765359,27488437,19028594,29412353,29745048,22826485,33238215,36095001,23104493,19877967,30048425,33693664,31129142,27688187,11388500,11428981,36613783,36314800,27784230,19878357,31351074,3099437,32725057,37028584,14999469,16235350,33632196,25978361,30365644,11696433,21120364,26183422,36096184,15039360,33789152,31536489,23965334,6804255,28844141,2203830,31376368,12435678,23133682,21991909,21991908,9140506,25789471,20423339,11068812,34302770,25512408,35038424,29577969,36844399,11869663,26774036,37001581,32569280,36534647,11129673,31145733,32393497,8098901,18788881,29309767,28167558,8762637,15779849,12392915,22869565,29666415,31254494,25275456,9790431,10881124,27223650,28560955,9431385,33750958,10724023,20140375,12499195,28944986,9209939,1903775,2518608,32356873,27622432,7885247,8115685,29768544,10882704,33238855,17486245,6418014,20510218,32571827,29745731,30728107,20566772,36809831,27356544,19100857,21165698,24378113,24773859,25184873,25184872,25184871,2499678,31988096,10881133,22199233,19327627,25411847,22802442,29513842,8688084,9756754,26272680,9129103,36093188,2487412,29357372,20428688,2117857,33986194,12128054,29867974,36638112,31816438,25461962,24037109,29987140,27216381,3932696,30938285,30953804,30622430,30868535,27993495,28720492,20493848,34133985,15158772,25583295,30111183,17619906,22450981,33539379,30033393,34804007,8269325,16963301,30320480,27627643,31362797,30020318,35830003,22917565,22754075,25075496,23967360,33177582,30381063,34504808,31419384,26974551,12384352,25140115,12769656,32293523,28870526,28767980,31456439,21460013,25946151,11334935,26202205,31104883,11289672,29987143,31685438,23114763,29016287,11357998,27324760,29089615,11891014,19738024,28620619,28242662,31771829,29016289,21909451,8470772,8246750,12644324,15361952,29906591,21801456,6404186,28001219,30562700,18512075,18991753,24976301,18332173,31754690,18439965,33301989,12853116,32804966,32169507,30962342,25114135,12910413,31801138,23473453,34203228,19723697,27748443,30001347,1842413,20027465,7649674,30098232,31299283,12505062,9840598,20464150,9806764,14554253,31670987,22777048,18660993,32376493,6443630,26854377,21738811,22215192,24247135,22028903,17151822,19410685,27466398,34365936,20547819,31340357,28831944,36315597,10546847,418744,20957215,23597573,17703333,10677750,1287919,35320825,28132566,3930564,10810325,19581464,30348750,31978590,2228230,33383023,25935204,22012216,9323096,25329323,17372764,28910299,31860098,19819909,24449777,23724050,34736749,30006773,24901991,31630056,15151147,32129856,9422841,35490799,30448310,29642963,31187704,26976879,8530923,25467276,25296657,28884498,2152191,28674032,23681190,33361290,32091491,9025688,3299901,11706667,27855177,15717098,9661019,11992141,20385875,35667455,9394539,22625224,11500440,11152439,8168945,29185981,10344642,17334537,28690148,32134269,9180594,7804521,24891470,34195872,28377930,11846839,10677754,27523778,27788262,11113049,30104093,8147485,12171584,26316715,30712412,28284779,20944987,30346948,3094145,26725535,30354432,24937048,30936158,17644389,27699992,8974045,31706289,19341528,15777198,36608168,1308556,34392087,8842112,21478242,20177904,31862616,20571548,18808305,20070438,26323936,34207619,30509941,29351667,9608814,24853169,22291940,24810753,32564978,32716934,2518281,17521394,26891837,31973605,27558676,19753472,12886468,12507836,21726660,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Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations.

Garcia S, Ramos CO, Senra JF, Vilas-Boas F, Rodrigues MM, Campos-de-Carvalho AC, Ribeiro-Dos-Santos R, Soares MB. Garcia S, et al. Antimicrob Agents Chemother. 2005 Apr;49(4):1521-8. doi: 10.1128/AAC.49.4.1521-1528.2005. Antimicrob Agents Chemother. 2005. PMID: 15793134 Free PMC article.

Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease.

Cevey ÁC, Mirkin GA, Donato M, Rada MJ, Penas FN, Gelpi RJ, Goren NB. Cevey ÁC, et al. Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):378-387. doi: 10.1016/j.ijpddr.2017.10.003. Epub 2017 Oct 7. Int J Parasitol Drugs Drug Resist. 2017. PMID: 29040909 Free PMC article.

Treatment of experimental chronic chagas disease with trifluralin.

Zaidenberg A, Luong T, Lirussi D, Bleiz J, Del Buono MB, Quijano G, Drut R, Kozubsky L, Marron A, Buschiazzo H. Zaidenberg A, et al. Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):351-6. doi: 10.1111/j.1742-7843.2006.pto_253.x. Basic Clin Pharmacol Toxicol. 2006. PMID: 16623857 Free article.

Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs.

Caldas IS, Menezes APJ, Diniz LF, Nascimento ÁFDSD, Novaes RD, Caldas S, Bahia MT. Caldas IS, et al. Acta Trop. 2019 Jan;189:30-38. doi: 10.1016/j.actatropica.2018.09.015. Epub 2018 Oct 2. Acta Trop. 2019. PMID: 30290285 Free article.

Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.

Corrales M, Cardozo R, Segura MA, Urbina JA, Basombrío MA. Corrales M, et al. Antimicrob Agents Chemother. 2005 Apr;49(4):1556-60. doi: 10.1128/AAC.49.4.1556-1560.2005. Antimicrob Agents Chemother. 2005. PMID: 15793138 Free PMC article.

Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.

Cevey ÁC, Mirkin GA, Penas FN, Goren NB. Cevey ÁC, et al. Int J Parasitol Drugs Drug Resist. 2015 Dec 12;6(1):12-22. doi: 10.1016/j.ijpddr.2015.12.001. eCollection 2016 Apr. Int J Parasitol Drugs Drug Resist. 2015. PMID: 26862474 Free PMC article.

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.

Francisco AF, Jayawardhana S, Taylor MC, Lewis MD, Kelly JM. Francisco AF, et al. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e00832-18. doi: 10.1128/AAC.00832-18. Print 2018 Oct. Antimicrob Agents Chemother. 2018. PMID: 30082291 Free PMC article.

Chagas disease: Present status of pathogenic mechanisms and chemotherapy.

Maya JD, Orellana M, Ferreira J, Kemmerling U, López-Muñoz R, Morello A. Maya JD, et al. Biol Res. 2010;43(3):323-31. Epub 2010 Nov 30. Biol Res. 2010. PMID: 21249304 Free article. Review.

Chagas' disease: lymphoma growth in rabbits treated with Benznidazole.

Teixeira AR, Córdoba JC, Souto Maior I, Solórzano E. Teixeira AR, et al. Am J Trop Med Hyg. 1990 Aug;43(2):146-58. doi: 10.4269/ajtmh.1990.43.146. Am J Trop Med Hyg. 1990. PMID: 2117856

Chagas cardiomyopathy: The potential effect of benznidazole treatment on diastolic dysfunction and cardiac damage in dogs chronically infected with Trypanosoma cruzi.

Santos FM, Mazzeti AL, Caldas S, Gonçalves KR, Lima WG, Torres RM, Bahia MT. Santos FM, et al. Acta Trop. 2016 Sep;161:44-54. doi: 10.1016/j.actatropica.2016.05.007. Epub 2016 May 20. Acta Trop. 2016. PMID: 27215760

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