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1

Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany.

Braun JM, Schneider B, Beuth HJ. Braun JM, et al. In Vivo. 2005 Mar-Apr;19(2):417-21. In Vivo. 2005. PMID: 15796206 Free article.

2

A comparative study of the effects of bromelain and fresh pineapple juice on the early phase of healing in acute crush achilles tendon injury.

Aiyegbusi AI, Olabiyi OO, Duru FI, Noronha CC, Okanlawon AO. Aiyegbusi AI, et al. J Med Food. 2011 Apr;14(4):348-52. doi: 10.1089/jmf.2010.0078. Epub 2011 Jan 23. J Med Food. 2011. PMID: 21254908

3

'Complementary ENT': a systematic review of commonly used supplements.

Karkos PD, Leong SC, Arya AK, Papouliakos SM, Apostolidou MT, Issing WJ. Karkos PD, et al. J Laryngol Otol. 2007 Aug;121(8):779-82. doi: 10.1017/S002221510600449X. Epub 2006 Nov 24. J Laryngol Otol. 2007. PMID: 17125579 Review.

4

In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.

Báez R, Lopes MT, Salas CE, Hernández M. Báez R, et al. Planta Med. 2007 Oct;73(13):1377-83. doi: 10.1055/s-2007-990221. Epub 2007 Sep 24. Planta Med. 2007. PMID: 17893836

5

In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.

Barth H, Guseo A, Klein R. Barth H, et al. Eur J Med Res. 2005 Aug 17;10(8):325-31. Eur J Med Res. 2005. PMID: 16131473

6

Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice.

Hale LP. Hale LP. Int Immunopharmacol. 2004 Feb;4(2):255-64. doi: 10.1016/j.intimp.2003.12.010. Int Immunopharmacol. 2004. PMID: 14996417

7

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.

Hale LP, Chichlowski M, Trinh CT, Greer PK. Hale LP, et al. Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. doi: 10.1002/ibd.21320. Inflamm Bowel Dis. 2010. PMID: 20848493 Free PMC article.

8

Stability, purification, and applications of bromelain: A review.

de Lencastre Novaes LC, Jozala AF, Lopes AM, de Carvalho Santos-Ebinuma V, Mazzola PG, Pessoa Junior A. de Lencastre Novaes LC, et al. Biotechnol Prog. 2016 Jan-Feb;32(1):5-13. doi: 10.1002/btpr.2190. Epub 2015 Nov 17. Biotechnol Prog. 2016. PMID: 26518672 Review.

9

Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.

Brien S, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. Brien S, et al. QJM. 2006 Dec;99(12):841-50. doi: 10.1093/qjmed/hcl118. QJM. 2006. PMID: 17121765 Clinical Trial.

10

Bromelain in the early phase of healing in acute crush Achilles tendon injury.

Aiyegbusi AI, Duru FI, Anunobi CC, Noronha CC, Okanlawon AO. Aiyegbusi AI, et al. Phytother Res. 2011 Jan;25(1):49-52. doi: 10.1002/ptr.3199. Phytother Res. 2011. PMID: 20623610

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