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17644301,19233470,10850458,15476220,18639283,24485799,20219657,17920664,19070610,16278420,18571148,16383255,19669740,18281555,15586362,16687078,18949380,15515013,18446845,18097580,10952788,17089060,17240363,15024582,17376583,17341629,15870934,12721754,14712319,16488717,16205633,18549279,16009488,18172270,16328054,27470351,16978604,16473670,17707793,20605144,18610750,15763542,17464329,14767553,15117815,19644355,17649631,18313654,16049707,16537920,19024104,18288380,16356494,15173094,18281366,17477369,23582784,16163705,16858664,16391833,17950073,17289901,20068080,15536623,16397046,15746940,16160080,19723072,17192871,18619431,18468578,20060030,15827088,15634570,17376296,17900752,12429973,16771729,17650409,16278386,28012958,17671705,12529993,12963997,18844115,18193228,18223231,15554914,24503697,19699753,15219811,18430063,17158768,19397994,17203205,18097623,18636159,18656338,16458111,20208452,17487507,18076794,17273739,16696967,15204521,19079835,17200366,14767529,18695876,12684681,16920736,17094463,15670579,16186804,17324379,17050058,15059137,15947789,11562446,16142381,16519769,16080505,16435156,12766035,16596246,17217918,16351789,15960896,15050731,22211246,15458505,21715447,15955213,15364280,17291531,22112863,16875574,16940799,17291540,15807244,17256134,16027227,22967175,17222494,16628227,17475221,16755652,22159450,24686006,15993584,20124937,17543181,16990052,15585644,16794187,15733867,21223683,17341627,18566246,11330947,15533593,15896459,15246561,15694660,10463621,17089062,11929951,15569418,15842781,16830229,17341630,15791453,16399772,12234611,16142328,17352252,19425186,19834889,16414351,16461312,17062697,15251435,22490658,15389598,16260035,17486059,16010429,21185843,16782069,16061681,17549398,12740064,16356831,17638069,15849726,10334897,12569581,20404560,26205347,16706789,17239344,21956461,17620292,16006969,12656675,21396995,17321782,16888791,17150304,11259528,21973234,19181544,17003423,22008852,16413651,23041555,17004718,20404564,17481908,16309217,17260803,20686505,15202011,11329487,20491440,16406939,16827155,15236626,20309941,15944781,21220410,15715472,16819292,16322264,12859874,17088416,29484736,22803372,11593419,15632825,16841078,16318858,11349829,15567975,15839997,16212876,16619528,16786142,16310807,29312470,30460772,23682781,16284694,15596294,17485212,27572311,17292358,23352703,15235588,12481415,19723065,26660520,15914281,17559025,16785996,20150619,16077924,20977880,16712893,15254669,12833141,16718685,17395767,17103031,21601631,21132604,17447750,16737765,16598766,12655437,16011614,15464061,20067818,15670648,17234786,27509880,20230682,10574969,15149153,16820966,15709169,15743317,21783889,17229588,16387551,16827150,17078109,17397803,23130838,17363503,12364480,20700043,11861795,11983830,17095187,21113745,15752352,20422883,17575161,22924958,15899785,15670817,22542671,17198874,17566113,23537658,11797827,20817931,12454024,16943765,16360016,28506690,17553359,16223781,11986788,22172403,22471490,17482960,21544732,17496430,1565475,17131292,15893818,16652187,21598070,22144016,23387080,21295294,15257900,17230511,25492515,15161027,15214780,28467787,12679801,16474387,18185535,25936363,16458119,17283158,17516137,21611810,18074352,21470575,10200457,16886001,16601366,22591439,20045224,26151768,17294043,17043661,28991639,32632663,17593629,18611394,27936791,16830153,15854272,22980865,17487366,16908595,22673765,27035641,22884094,19308286,15659846,31712669,22931124,17094483,27472459,15042312,17603010,11561678,15962304,10362104,29187454,20811699,16697099,25674209,17154519,22968522,24416998,19450997,24679699,16970931,16098658,25781909,26683357,28641053,16764854,17212786,16739131,25573651,17185222,17223102,16373706,19647486,27425252,20724917,20126671,10434949,20931760,30529073,20231098,23128353,33670166,17308048,15585556,16272168,20450546,21198545,38480975,25977922,18483296,15473647,22950819,16966184,25914207,37224749,25776505,16329155,17192465,9877027,19968870,20624163,16936743,15186849,12767524,19269967,17169856,11171632,16751067,35807258,19588502,17218785,18821579,31954012,21080855,36709169,27235706,30111417,22831968,14996704,21820027,17365146,31635244,9859785,32973968,7664834,30579954,21196698,17147243,16931865,23928161,15556009,21223552,19578794,28406576,9586815,15308524,9413222,19506904,16392174,24589486,16465291,16909308,27588384,16930895,16900630,15720807,22748449,28119491,34050002,21900747,17410604,17234448,24438145,15670922,29493465,17081760,22066664,18981008,21357443,16205627,23757352,23128821,23991922,31289512,23106301,17234411,18577263,18991384,24595447,27893752,19860623,26473529,25948203,11675364,20820782,22931650,20137112,16528450,11170101,19951261,24304587,30885250,15466934,19680741,11877306,14990341,17512775,26221255,24480041,25621063,20123594,10953380,22279936,19384944,36947367,25616967,35557040,33508992,25134723,22050341,19608677,26011634,17979809,26906133,23955090,33907850,28588720,15979003,16600370,19874311,34340691,25979924,21718714,34144348,35099714,27446382,34214254,19212861,27657380,26131123,34007797,15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Romidepsin (depsipeptide) induced cell cycle arrest, apoptosis and histone hyperacetylation in lung carcinoma cells (A549) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression.

Vinodhkumar R, Song YS, Devaki T. Vinodhkumar R, et al. Biomed Pharmacother. 2008 Feb;62(2):85-93. doi: 10.1016/j.biopha.2007.06.002. Epub 2007 Jun 29. Biomed Pharmacother. 2008. PMID: 17644301

Depsipeptide induces cell death in Hodgkin lymphoma-derived cell lines.

Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D. Hartlapp I, et al. Leuk Res. 2009 Jul;33(7):929-36. doi: 10.1016/j.leukres.2008.12.013. Epub 2009 Feb 23. Leuk Res. 2009. PMID: 19233470

Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis.

Park WH, Seol JG, Kim ES, Hyun JM, Jung CW, Lee CC, Kim BK, Lee YY. Park WH, et al. Cancer Res. 2000 Jun 1;60(11):3065-71. Cancer Res. 2000. PMID: 10850458

Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expression.

Nishida K, Komiyama T, Miyazawa S, Shen ZN, Furumatsu T, Doi H, Yoshida A, Yamana J, Yamamura M, Ninomiya Y, Inoue H, Asahara H. Nishida K, et al. Arthritis Rheum. 2004 Oct;50(10):3365-76. doi: 10.1002/art.20709. Arthritis Rheum. 2004. PMID: 15476220

Decreased acetylation of histone H3 in renal cell carcinoma: a potential target of histone deacetylase inhibitors.

Kanao K, Mikami S, Mizuno R, Shinojima T, Murai M, Oya M. Kanao K, et al. J Urol. 2008 Sep;180(3):1131-6. doi: 10.1016/j.juro.2008.04.136. Epub 2008 Jul 18. J Urol. 2008. PMID: 18639283

Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells.

Karthik S, Sankar R, Varunkumar K, Ravikumar V. Karthik S, et al. Biomed Pharmacother. 2014 Apr;68(3):327-34. doi: 10.1016/j.biopha.2014.01.002. Epub 2014 Jan 15. Biomed Pharmacother. 2014. PMID: 24485799

HY253, a novel decahydrofluorene analog, from Aralia continentalis, induces cell cycle arrest at the G1 phase and cytochrome c-mediated apoptosis in human lung cancer A549 cells.

Oh HL, Lee DK, Lim H, Lee CH. Oh HL, et al. J Ethnopharmacol. 2010 May 4;129(1):135-9. doi: 10.1016/j.jep.2010.02.010. Epub 2010 Feb 26. J Ethnopharmacol. 2010. PMID: 20219657

A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells.

Ahn MY, Jung JH, Na YJ, Kim HS. Ahn MY, et al. Gynecol Oncol. 2008 Jan;108(1):27-33. doi: 10.1016/j.ygyno.2007.08.098. Epub 2007 Oct 24. Gynecol Oncol. 2008. PMID: 17920664

Mechanism of apicidin-induced cell cycle arrest and apoptosis in Ishikawa human endometrial cancer cells.

Ahn MY, Lee J, Na YJ, Choi WS, Lee BM, Kang KW, Kim HS. Ahn MY, et al. Chem Biol Interact. 2009 May 15;179(2-3):169-77. doi: 10.1016/j.cbi.2008.11.011. Epub 2008 Nov 25. Chem Biol Interact. 2009. PMID: 19070610

Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells.

Hoshino I, Matsubara H, Hanari N, Mori M, Nishimori T, Yoneyama Y, Akutsu Y, Sakata H, Matsushita K, Seki N, Ochiai T. Hoshino I, et al. Clin Cancer Res. 2005 Nov 1;11(21):7945-52. doi: 10.1158/1078-0432.CCR-05-0840. Clin Cancer Res. 2005. PMID: 16278420

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