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17687110,28484685,15542642,23084770,25433216,27803169,29046309,10899868,27533046,24333518,28736197,22561312,12117906,25872480,25483698,22858557,1681365,29150208,26362430,31629569,27889616,11447145,23474241,24342246,17725620,26239100,23916987,30886613,27107614,11145916,24429069,30443257,12165550,20032542,18332214,16914239,9522876,8648213,25902362,9234794,27147749,29683766,19428847,9919662,28495314,22305172,24990902,27634430,17582563,18805452,25722486,22492745,19806505,15386434,17347563,15243933,25785935,26084199,28196735,30820452,34635698,2180232,27058179,18706861,28706878,24385413,26304732,24440210,23593253,9878043,25668661,29851031,29507892,22717329,19174177,25483463,12594304,30952553,10603389,18780634,25575128,11755415,23990055,12531339,26003490,2807550,25660110,21146460,30953793,15149786,17034867,17239496,15890912,23924054,12531639,17936447,28873442,26741681,28268075,17502396,22401308,8438611,30951606,26382603,34516991,30487152,8336003,31874075,17928109,27216239,24831232,31147274,2669099,17636661,7520650,23053636,29681410,31645650,15989783,7890391,28856924,11563251,29967094,2101470,10796623,23616408,17822733,18690012,26810369,22426329,19126233,20660136,31804525,15845258,21803095,15557633,2180234,2010645,31612941,30836838,30502020,12183559,31781100,23637957,27140662,2493838,22446857,10225867,33636291,30254257,31381497,22293302,12692223,28515625,10439932,21300096,26901576,9682329,23752042,16414157,6131224,1398937,27083427,24837778,7705608,27515281,29739901,8821644,8432597,27244269,18445338,35703545,28965718,3312013,17182155,2883393,24142729,30346608,1692807,9772310,26381401,33388175,22356831,11231208,30560935,17531764,9027185,19200837,33807097,11158207,18156796,17995958,15494539,28056100,6389350,32510304,12798649,30360122,22705173,30926288,10506405,19421199,25943066,8438612,3373028,9066045,27518899,2363299,23105026,24156285,28739115,30767002,30459071,1988518,9465097,18473731,20585446,18175039,28637001,33975015,32065303,29359991,33343580,11727495,20434552,26925750,25998436,1997425,28060810,32565239,32098623,28735760,24630869,12798615,33424833,15595386,29861180,11748663,26401038,11738748,6754614,8310758,28675263,18086370,15271924,23108357,31452045,25808163,23458379,3188615,24802101,29854852,34434742,32133000,1634818,11166893,23432484,6378786,31021700,9772307,1683437,19901429,16256052,23406777,21248155,2902303,27523740,16863657,30018230,8488717,20211219,26025174,17439745,20107010,25998700,16501072,15464846,29637494,7590891,29785477,16391114,20600940,1890950,18650399,30593739,10882658,27233002,7784125,25902360,21447051,30252031,10905949,30845320,29031693,12228290,28282600,6207249,19961961,8027333,28189484,19769155,34265371,10582163,1727891,7037982,9846359,20696192,20601795,2363303,19884333,21549786,1431270,32725225,26608168,21115057,30216367,32720632,22465750,28012703,32238006,16299315,27869515,29203881,10462227,6174449,20534981,32859464,19223478,12807954,24290842,12213392,20563641,22669586,8945569,19889941,10869765,13886261,9178472,27236002,3417354,29959021,30923521,13886262,14742517,21628517,18663003,24161937,36263027,18483320,25203446,10548572,6366077,11775264,33309485,1419117,21402763,21061438,32203521,28780192,15096553,10480549,20833377,29800575,28498925,29743315,16251048,11348726,23722024,16670757,1725837,33573433,28004837,27655911,19647066,24040177,19741090,26090426,17581283,35568365,18385253,17596427,25187406,33651712,35475682,26994209,7725064,10689234,10678926,8002060,28965714,27673328,9086143,7975830,28222997,9462316,23860765,2385993,9587187,2087881,12915537,8165850,19155521,35750538,36624251,10974947,29387052,28544285,12065485,25929429,1730477,31729940,30767000,12413664,1976928,1296295,23677323,6702364,33160073,22085463,13886263,34664812,34452413,18482559,2385994,27485136,22679502,34648579,2058266,29958737,23124750,17428949,18474649,29022005,4018068,20112696,14497411,11895968,20668668,9916080,6028241,17596432,28267627,19124765,19221516,19809263,26303218,24400067,3106921,20951970,34764353,3905619,32332752,35713798,9989208,9987143,19851830,7415680,10569759,34384541,24639327,19457985,25789464,54336,16343383,18491213,23414405,16270153,1574915,3681191,12163256,24491597,1607701,23162127,30047368,31190683,10657605,10816483,7551062,27809955,17584165,30696629,10738102,22030867,11875976,23664993,22027487,18260212,12531654,24307238,7908379,1937790,27797598,4553079,17214363,18414690,32304786,26446387,25860480,1397669,2022863,36286551,10195609,29287062,21729769,32900928,23417073,24714383,36228043,31665775,378849,31160100,28167670,23658208,25101794,28726109,19099487,30287156,19417771,25910921,23969054,32804950,18365691,25811680,29914845,1612747,33665941,11179942,23591641,19710294,4780106,9413086,8488716,7210105,23408152,21185706,2613709,32827141,10937771,33301931,22563414,25444695,24759938,32661121,24273182,26928826,19746165,9014288,20953154,25912286,30170987,1730487,16721633,25751641,9826335,22987290,24053397,1848888,26449939,33318138,3438648,1716810,8427032,24519873,8139873,34942089,2754534,5729697,30767005,809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Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever.

Fraillery D, Baud D, Pang SY, Schiller J, Bobst M, Zosso N, Ponci F, Nardelli-Haefliger D. Fraillery D, et al. Clin Vaccine Immunol. 2007 Oct;14(10):1285-95. doi: 10.1128/CVI.00164-07. Epub 2007 Aug 8. Clin Vaccine Immunol. 2007. PMID: 17687110 Free PMC article.

Vi Capsular Polysaccharide Produced by Recombinant Salmonella enterica Serovar Paratyphi A Confers Immunoprotection against Infection by Salmonella enterica Serovar Typhi.

Xiong K, Zhu C, Chen Z, Zheng C, Tan Y, Rao X, Cong Y. Xiong K, et al. Front Cell Infect Microbiol. 2017 Apr 24;7:135. doi: 10.3389/fcimb.2017.00135. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28484685 Free PMC article.

Improved efficiency of a Salmonella-based vaccine against human papillomavirus type 16 virus-like particles achieved by using a codon-optimized version of L1.

Baud D, Ponci F, Bobst M, De Grandi P, Nardelli-Haefliger D. Baud D, et al. J Virol. 2004 Dec;78(23):12901-9. doi: 10.1128/JVI.78.23.12901-12909.2004. J Virol. 2004. PMID: 15542642 Free PMC article.

Live oral typhoid vaccine Salmonella Typhi Ty21a - a surrogate vaccine against non-typhoid salmonella?

Kantele A, Pakkanen SH, Siitonen A, Karttunen R, Kantele JM. Kantele A, et al. Vaccine. 2012 Nov 26;30(50):7238-45. doi: 10.1016/j.vaccine.2012.10.002. Epub 2012 Oct 17. Vaccine. 2012. PMID: 23084770 Free article.

Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly.

Pakkanen SH, Kantele JM, Savolainen LE, Rombo L, Kantele A. Pakkanen SH, et al. Vaccine. 2015 Jan 9;33(3):451-8. doi: 10.1016/j.vaccine.2014.11.030. Epub 2014 Nov 26. Vaccine. 2015. PMID: 25433216 Free article.

Development of a Live Attenuated Bivalent Oral Vaccine Against Shigella sonnei Shigellosis and Typhoid Fever.

Wu Y, Chakravarty S, Li M, Wai TT, Hoffman SL, Sim BK. Wu Y, et al. J Infect Dis. 2017 Jan 15;215(2):259-268. doi: 10.1093/infdis/jiw528. J Infect Dis. 2017. PMID: 27803169 Free PMC article.

Stable Chromosomal Expression of Shigella flexneri 2a and 3a O-Antigens in the Live Salmonella Oral Vaccine Vector Ty21a.

Dharmasena MN, Osorio M, Takeda K, Stibitz S, Kopecko DJ. Dharmasena MN, et al. Clin Vaccine Immunol. 2017 Dec 5;24(12):e00181-17. doi: 10.1128/CVI.00181-17. Print 2017 Dec. Clin Vaccine Immunol. 2017. PMID: 29046309 Free PMC article.

Constitutive expression of the Vi polysaccharide capsular antigen in attenuated Salmonella enterica serovar typhi oral vaccine strain CVD 909.

Wang JY, Noriega FR, Galen JE, Barry E, Levine MM. Wang JY, et al. Infect Immun. 2000 Aug;68(8):4647-52. doi: 10.1128/IAI.68.8.4647-4652.2000. Infect Immun. 2000. PMID: 10899868 Free PMC article.

Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA, Moore M, Thompson BA, John T, Kingsley RA, Yu LM, Voysey M, Hindle Z, Lockhart S, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ. Darton TC, et al. PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004926. doi: 10.1371/journal.pntd.0004926. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27533046 Free PMC article. Clinical Trial.

Fusion of HPV L1 into Shigella surface IcsA: a new approach in developing live attenuated Shigella-HPV vaccine.

Xu D, Wang D, Yang X, Cao M, Yu J, Wang Y. Xu D, et al. Antiviral Res. 2014 Feb;102:61-9. doi: 10.1016/j.antiviral.2013.12.003. Epub 2013 Dec 13. Antiviral Res. 2014. PMID: 24333518

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