Similar articles for PMID: 22879384

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1

Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.

Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter CC, Clanachan AS, Light PE. Soliman D, et al. J Pharmacol Exp Ther. 2012 Nov;343(2):325-32. doi: 10.1124/jpet.112.196949. Epub 2012 Aug 9. J Pharmacol Exp Ther. 2012. PMID: 22879384

2

Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.

Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS. Fraser H, et al. J Mol Cell Cardiol. 2006 Dec;41(6):1031-8. doi: 10.1016/j.yjmcc.2006.08.012. Epub 2006 Oct 5. J Mol Cell Cardiol. 2006. PMID: 17027025

3

Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.

Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC. Hoyer K, et al. J Pharmacol Exp Ther. 2011 May;337(2):513-23. doi: 10.1124/jpet.110.176776. Epub 2011 Feb 16. J Pharmacol Exp Ther. 2011. PMID: 21325441

4

Ranolazine attenuates the enhanced reverse Na⁺-Ca²⁺ exchange current via inhibiting hypoxia-increased late sodium current in ventricular myocytes.

Wang XJ, Wang LL, Fu C, Zhang PH, Wu Y, Ma JH. Wang XJ, et al. J Pharmacol Sci. 2014;124(3):365-73. doi: 10.1254/jphs.13202fp. Epub 2014 Feb 27. J Pharmacol Sci. 2014. PMID: 24572816 Free article.

5

Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.

Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD. Burr AR, et al. Mol Cell Biol. 2014 Jun;34(11):1991-2002. doi: 10.1128/MCB.00339-14. Epub 2014 Mar 24. Mol Cell Biol. 2014. PMID: 24662047 Free PMC article.

6

Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.

Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Song Y, et al. J Pharmacol Exp Ther. 2006 Jul;318(1):214-22. doi: 10.1124/jpet.106.101832. Epub 2006 Mar 24. J Pharmacol Exp Ther. 2006. PMID: 16565163

7

Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA. Aistrup GL, et al. Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1068-79. doi: 10.1152/ajpheart.00401.2013. Epub 2013 Jul 19. Am J Physiol Heart Circ Physiol. 2013. PMID: 23873796 Free PMC article.

8

Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit.

Hale SL, Kloner RA. Hale SL, et al. J Cardiovasc Pharmacol Ther. 2006 Dec;11(4):249-55. doi: 10.1177/1074248406294607. J Cardiovasc Pharmacol Ther. 2006. PMID: 17220471

9

Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine.

Belardinelli L, Shryock JC, Fraser H. Belardinelli L, et al. Heart. 2006 Jul;92 Suppl 4(Suppl 4):iv6-iv14. doi: 10.1136/hrt.2005.078790. Heart. 2006. PMID: 16775092 Free PMC article.

10

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.

Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber SL, Schöndube FA, Tirilomis T, Tenderich G, Hasenfuss G, Belardinelli L, Maier LS. Sossalla S, et al. J Mol Cell Cardiol. 2008 Jul;45(1):32-43. doi: 10.1016/j.yjmcc.2008.03.006. Epub 2008 Mar 14. J Mol Cell Cardiol. 2008. PMID: 18439620

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