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25701956,22719182,17942460,17054581,19526325,18618713,25557234,25076244,20045164,26247575,26552419,24443998,19690142,15118395,21868491,25194673,17312306,17962726,17545526,23553055,17453358,24333619,16106253,24493211,16885385,25816162,26116798,18257912,17688369,22368298,22498935,18206535,23354017,20920750,19551857,25636458,22278153,24503759,29439113,24643686,22883484,27601186,22034109,21953887,25311944,20373145,27013479,22552011,29055842,19455606,16837128,22189970,25722176,19728162,27038793,21791569,31491536,25782445,19424639,21766496,26895074,31307542,15289847,28591715,25213383,10793088,20164541,31273487,24614649,34302852,18809606,18679418,17628916,34407589,22081473,19360696,26096739,27273229,9927063,18990764,23648460,19564652,18022218,30561401,17473388,20388775,20655395,27220764,22776989,29575718,18415027,30989425,25637498,27838401,31386297,28573495,20102720,31926173,28176205,28895526,28643016,19949877,26873718,24624982,18523027,30420047,33053554,20473912,22496206,25372301,27938333,23880961,33915653,29596542,33393477,10072435,26309352,31150123,20195377,32449172,34397043,25908759,31554352,25213678,26644264,26319271,35346574,17117178,20351277,26001389,17636426,23401454,22086678,21311894,20495087,15528793,21681552,28514183,31998307,24034859,29327160,17192056,27152634,28819720,27302833,15749592,22144422,28819700,21598002,31932681,30803214,29400022,30376427,28528517,31248416,20979647,31980219,22274583,26224055,23729658,22262812,19957108,22854115,19821155,30551794,30916491,23712482,23702729,29472252,30998989,28577310,29783979,23888949,28376875,20872076,22691310,23049789,20864635,31811435,29758216,30063919,27398995,30693488,24964857,30279230,19958615,30543514,24278394,25762362,31494577,30575961,28696559,27527654,19621678,26249337,34667028,31537299,30387329,34091457,18556776,22017758,21136174,28218421,28709704,37101184,19241144,10498615,28195261,17530287,27990589,22302899,20063070,16012936,26697123,17534377,21387278,26875156,31745674,26886015,22345660,36754896,31609810,35446842,27447752,27221876,20824433,28693799,24048684,23797718,21227399,16341479,28699072,23484096,34311271,31220642,29701748,28874631,33276219,23555086,35695349,21286823,21327300,26101330,36682091,24084575,22890886,28785832,32822722,32002723,30217226,19622357,20682701,26149658,17022696,31649038,17186090,21140452,34807001,22899370,34172528,21769135,28206961,27742654,32844218,22120844,20924129,27258561,27965287,19466295,26485756,29659608,29531926,19638594,28741532,21645411,24244552,36293153,14504054,27984238,33279946,21875327,20416305,20516444,21822721,36833239,33199489,26781822,28664346,22940821,30802454,31607698,28471193,21120944,21431882,30527816,35395112,20967208,27422471,32620917,33468869,14760069,21844009,32510614,33182707,32710312,26185136,29161904,28103454,30789355,28616688,36775405,19324997,34919656,31307113,31068195,26724419,35638907,33608032,28066040,21484480,24811117,27186853,30713006,33645631,30747051,36905693,27754426,18941508,29405992,15831578,26298861,35990637,24518836,34630437,28397474,19383812,22348132,24040339,24802709,24710284,26648449,27363726,35900537,34519923,33464460,20198652,22763379,36115290,33411254,36591511,31292272,27487738,28690196,27300758,27977020,32340874,30116770,30614234,34042092,20013806,22426235,31028081,30303141,32108923,27670258,27129500,26884349,30543589,31056702,30829280,23029359,19125126,26300262,34044097,35789992,27896849,31297337,28705114,21247423,30449841,34848827,35197584,18337503,33631043,35849120,31145962,31392519,30881489,21681432,22249440,25224212,26523369,28728506,33290824,17465465,29528821,18941461,34398969,35583999,11734538,27150435,25716099,17109103,28471861,28548127,23760948,25429050,26951660,32377987,14871813,33539189,26746812,26885030,23730227,29669262,26888055,26786868,36319582,21115420,16821093,16136387,22949379,18936738,20489114,28974240,24073290,28701629,32582376,28259170,31822864,22987205,34916366,18076065,31089268,18446350,29898989,26960970,27863258,20142816,27873144,26831756,31274083,27810331,21388066,33010064,23462881,20665498,28485341,32356167,27060000,23264089,21637783,30072391,30578081,31237724,19156169,34224739,34503257,26613680,34201893,33521965,30340772,20012372,37143941,20420947,29983889,25255306,35267422,29866945,27571988,25680569,22348133,35806077,11257106,18056700,28224663,36541070,25767621,28293308,16675567,35457101,27016223,27941880,30665466,22581703,27783137,21636617,28367107,34936649,10549359,31445773,29375743,35567574,29735329,22658618,20672385,35688320,29743854,27744626,30173944,32512823,17192057,26880610,29238914,17192061,30119911,33930657,26697201,27729169,31296810,23259788,16417627,27468871,33000102,33433757,26616728,21957315,19179424,30027543,29158190,27558481,35149954,29776633,26216840,35262923,26786262,35320449,24196629,25469011,25599959,11391614,35708161,23760517,28416640,32875553,22933939,30121009,25450519,18543306,27241104,32641106,32326378,34312297,24878972,29490919,17177835,25929864,33767077,26774442,27513077,28664474,29849807,34079322,34148153,24393962,240569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Microsatellite instability: an update.

Yamamoto H, Imai K. Yamamoto H, et al. Arch Toxicol. 2015 Jun;89(6):899-921. doi: 10.1007/s00204-015-1474-0. Epub 2015 Feb 22. Arch Toxicol. 2015. PMID: 25701956 Review.

Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.

Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y. Yamamoto H, et al. World J Gastroenterol. 2012 Jun 14;18(22):2745-55. doi: 10.3748/wjg.v18.i22.2745. World J Gastroenterol. 2012. PMID: 22719182 Free PMC article. Review.

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.

Imai K, Yamamoto H. Imai K, et al. Carcinogenesis. 2008 Apr;29(4):673-80. doi: 10.1093/carcin/bgm228. Epub 2007 Oct 17. Carcinogenesis. 2008. PMID: 17942460 Review.

Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer.

Sheng JQ, Chan TL, Chan YW, Huang JS, Chen JG, Zhang MZ, Guo XL, Mu H, Chan AS, Li SR, Yuen ST, Leung SY. Sheng JQ, et al. Chin J Dig Dis. 2006;7(4):197-205. doi: 10.1111/j.1443-9573.2006.00269.x. Chin J Dig Dis. 2006. PMID: 17054581

Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome.

Berginc G, Bracko M, Ravnik-Glavac M, Glavac D. Berginc G, et al. Fam Cancer. 2009;8(4):421-9. doi: 10.1007/s10689-009-9258-4. Epub 2009 Jun 13. Fam Cancer. 2009. PMID: 19526325

Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients.

Alemayehu A, Sebova K, Fridrichova I. Alemayehu A, et al. Genes Chromosomes Cancer. 2008 Oct;47(10):906-14. doi: 10.1002/gcc.20586. Genes Chromosomes Cancer. 2008. PMID: 18618713

Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancer.

Moreira L, Muñoz J, Cuatrecasas M, Quintanilla I, Leoz ML, Carballal S, Ocaña T, López-Cerón M, Pellise M, Castellví-Bel S, Jover R, Andreu M, Carracedo A, Xicola RM, Llor X, Boland CR, Goel A, Castells A, Balaguer F; Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Moreira L, et al. Cancer. 2015 May 1;121(9):1395-404. doi: 10.1002/cncr.29190. Epub 2014 Dec 29. Cancer. 2015. PMID: 25557234 Free PMC article.

BRAF mutation analysis is a valid tool to implement in Lynch syndrome diagnosis in patients classified according to the Bethesda guidelines.

Molinari F, Signoroni S, Lampis A, Bertan C, Perrone F, Sala P, Mondini P, Crippa S, Bertario L, Frattini M. Molinari F, et al. Tumori. 2014 May-Jun;100(3):315-20. doi: 10.1700/1578.17214. Tumori. 2014. PMID: 25076244

Taiwan hospital-based detection of Lynch syndrome distinguishes 2 types of microsatellite instabilities in colorectal cancers.

Chang SC, Lin PC, Yang SH, Wang HS, Liang WY, Lin JK. Chang SC, et al. Surgery. 2010 May;147(5):720-8. doi: 10.1016/j.surg.2009.10.069. Epub 2009 Dec 31. Surgery. 2010. PMID: 20045164

Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation.

Pinheiro M, Pinto C, Peixoto A, Veiga I, Lopes P, Henrique R, Baldaia H, Carneiro F, Seruca R, Tomlinson I, Kovac M, Heinimann K, Teixeira MR. Pinheiro M, et al. Br J Cancer. 2015 Aug 11;113(4):686-92. doi: 10.1038/bjc.2015.281. Epub 2015 Aug 6. Br J Cancer. 2015. PMID: 26247575 Free PMC article.

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