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26077004,25183481,23167843,21994416,23324806,20177422,24890702,22584434,24727325,23930206,24331409,19854534,28756651,23374602,26162609,20603437,20676756,23010994,25158139,20413299,24742565,26573509,22489692,26711930,18782444,18922928,24200637,20619739,20563851,27637917,19380522,24339949,23302304,23849768,19096301,23763264,21435948,23297805,27999344,25053852,19001320,25902737,32000721,24861115,24139827,21029218,27270901,23157823,21969500,21258250,25267307,25472647,19474002,23773459,23157824,24281417,20049644,26281864,22982650,22005474,23606169,19937133,24833563,25886136,21340604,24549645,26081767,25445553,29694444,25361550,23548132,23324583,22458769,26616848,22579930,28150169,24659028,19603018,26691448,23157825,25127693,28170370,27460045,26515332,29048669,27620744,31296605,23511557,31729406,27756406,22189714,29374690,27405731,25687873,27068338,23975373,22679560,19453520,30523411,28179313,30661213,28811082,19309232,26740498,28235632,23010532,26413866,28636636,30029640,28365952,31790621,29743116,27072218,26690310,27743339,26316738,26749281,28618197,27116474,25363767,29048575,28097409,26418750,30406144,30544177,32149725,27311775,27248473,27218826,30121958,30791218,28368426,31319984,32274564,27509933,28956302,27037031,26338018,25946211,27509985,27461636,30799393,28610418,30132520,27221928,27998182,27256640,26722374,30884019,26918901,28044264,27100819,22325812,30997628,29567812,30223391,31597436,28749408,29042709,26701781,28328955,25844824,27837635,29703759,24552817,27179269,27195424,28259994,27805251,25888436,28647837,29577691,27433082,31152438,26846215,31641854,25940428,28289141,24932237,27394063,29304017,21698197,27526306,27578453,29604399,28106826,27951718,26110767,22307873,28692044,28551386,32119223,32552000,18593984,24884535,30121367,30623364,28403349,25210463,25961464,30932013,31545548,25870796,29061646,31401029,32664155,32495109,23255930,21258883,22669132,31185482,26366557,30976068,21574647,29298116,31133691,26375816,29788743,28708207,26450180,26315966,30876538,26299862,31529566,12781426,28398227,26132860,26554912,26752307,27753016,23441611,21691751,30264648,31092436,32010574,28238063,20569491,31156795,29341112,21807336,27499912,23226727,12601529,22969966,29688256,28095174,27606136,24391853,22167334,28881604,32876508,28031051,31283584,25924068,24919860,29137388,27867401,27899776,27110502,27994469,20505728,33030125,32277629,28102343,23205087,27959684,10709089,30858756,28668886,27816716,24649147,33209599,27335808,31729889,26829579,32528529,26157327,29155516,22740923,32527755,27843640,24834285,29085667,31634775,29970558,32054005,14728592,23730412,12699056,28194229,2021539,32594310,1647921,30858928,32184228,32147669,30798277,11290637,23028236,21336946,29911107,11422654,23457874,23231948,33183271,24482642,33145304,31516745,23231949,31571990,22442060,26841056,31966531,27935690,31821386,32685110,32719100,24748981,28747664,30460115,31169290,32856845,26982187,29528359,29669234,31949936,32924269,31227255,26870292,29703472,32418154,25205120,29671469,23961365,28966582,32249344,30233821,32613839,29066916,26090587,22855162,25880439,31586294,3171026,28947298,31469415,21364863,32978518,31949508,27747008,31508470,32734521,24648925,30622849,32332709,10204664,27790634,21573597,25389090,31414178,23374226,31189530,32540954,31686011,33115812,31043737,24353399,13037040,31815009,23247375,30556602,26682268,27918429,28846116,8643009,27088596,14943631,30331579[uid]

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Results by year

Year	Number of Results
1805	1
1952	1
1953	1
1988	1
1991	2
1993	1
1996	1
1999	1
2000	1
2001	2
2003	4
2008	4
2009	6
2010	14
2011	19
2012	32
2013	32
2014	27
2015	41
2016	64
2017	49
2018	34
2019	51
2020	37

378 results

Results by year

Page 1

Comparison of the prevalence of KRAS-LCS6 polymorphism (rs61764370) within different tumour types (colorectal, breast, non-small cell lung cancer and brain tumours). A study of the Czech population.

Uvirova M, Simova J, Kubova B, Dvorackova N, Tomaskova H, Sedivcova M, Dite P. Uvirova M, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):466-71. doi: 10.5507/bp.2015.029. Epub 2015 Jun 11. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015. PMID: 26077004 Free article.

A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy.

Saridaki Z, Weidhaas JB, Lenz HJ, Laurent-Puig P, Jacobs B, De Schutter J, De Roock W, Salzman DW, Zhang W, Yang D, Pilati C, Bouché O, Piessevaux H, Tejpar S. Saridaki Z, et al. Clin Cancer Res. 2014 Sep 1;20(17):4499-4510. doi: 10.1158/1078-0432.CCR-14-0348. Clin Cancer Res. 2014. PMID: 25183481 Free PMC article.

Let-7 miRNA-binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/- cetuximab.

Kjersem JB, Ikdahl T, Guren T, Skovlund E, Sorbye H, Hamfjord J, Pfeiffer P, Glimelius B, Kersten C, Solvang H, Tveit KM, Kure EH. Kjersem JB, et al. BMC Cancer. 2012 Nov 20;12:534. doi: 10.1186/1471-2407-12-534. BMC Cancer. 2012. PMID: 23167843 Free PMC article. Clinical Trial.

A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer.

Smits KM, Paranjape T, Nallur S, Wouters KA, Weijenberg MP, Schouten LJ, van den Brandt PA, Bosman FT, Weidhaas JB, van Engeland M. Smits KM, et al. Clin Cancer Res. 2011 Dec 15;17(24):7723-31. doi: 10.1158/1078-0432.CCR-11-0990. Epub 2011 Oct 12. Clin Cancer Res. 2011. PMID: 21994416 Free PMC article.

The LCS6 polymorphism in the binding site of let-7 microRNA to the KRAS 3'-untranslated region: its role in the efficacy of anti-EGFR-based therapy in metastatic colorectal cancer patients.

Sebio A, Paré L, Páez D, Salazar J, González A, Sala N, del Río E, Martín-Richard M, Tobeña M, Barnadas A, Baiget M. Sebio A, et al. Pharmacogenet Genomics. 2013 Mar;23(3):142-7. doi: 10.1097/FPC.0b013e32835d9b0b. Pharmacogenet Genomics. 2013. PMID: 23324806

Genetic modulation of the Let-7 microRNA binding to KRAS 3'-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan.

Graziano F, Canestrari E, Loupakis F, Ruzzo A, Galluccio N, Santini D, Rocchi M, Vincenzi B, Salvatore L, Cremolini C, Spoto C, Catalano V, D'Emidio S, Giordani P, Tonini G, Falcone A, Magnani M. Graziano F, et al. Pharmacogenomics J. 2010 Oct;10(5):458-64. doi: 10.1038/tpj.2010.9. Epub 2010 Feb 23. Pharmacogenomics J. 2010. PMID: 20177422 Free article. Clinical Trial.

Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis.

Langevin SM, Christensen BC. Langevin SM, et al. Cancer Med. 2014 Oct;3(5):1385-95. doi: 10.1002/cam4.279. Epub 2014 Jun 2. Cancer Med. 2014. PMID: 24890702 Free PMC article. Review.

High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease.

Ruzzo A, Graziano F, Vincenzi B, Canestrari E, Perrone G, Galluccio N, Catalano V, Loupakis F, Rabitti C, Santini D, Tonini G, Fiorentini G, Rossi D, Falcone A, Magnani M. Ruzzo A, et al. Oncologist. 2012;17(6):823-9. doi: 10.1634/theoncologist.2012-0081. Epub 2012 May 14. Oncologist. 2012. PMID: 22584434 Free PMC article.

Association study of the let-7 miRNA-complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer (NCCTG N0147 Clinical Trial).

Sha D, Lee AM, Shi Q, Alberts SR, Sargent DJ, Sinicrope FA, Diasio RB. Sha D, et al. Clin Cancer Res. 2014 Jun 15;20(12):3319-27. doi: 10.1158/1078-0432.CCR-14-0069. Epub 2014 Apr 11. Clin Cancer Res. 2014. PMID: 24727325 Free PMC article. Clinical Trial.

EGFR, KRAS, BRAF, and HER-2 molecular status in brain metastases from 77 NSCLC patients.

Villalva C, Duranton-Tanneur V, Guilloteau K, Burel-Vandenbos F, Wager M, Doyen J, Levillain PM, Fontaine D, Blons H, Pedeutour F, Karayan-Tapon L. Villalva C, et al. Cancer Med. 2013 Jun;2(3):296-304. doi: 10.1002/cam4.82. Epub 2013 Apr 23. Cancer Med. 2013. PMID: 23930206 Free PMC article.