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28099148,28667779,16707469,24626405,29211704,24935393,20596669,24130769,26936390,20198346,22369900,16550602,24618889,24033428,17671692,18025281,21491416,17351739,27926517,16377638,21107885,25888415,27163855,26314218,17417771,24236158,29290529,19509267,23583193,26587975,17390020,18156316,23620163,24297449,25763653,20838997,34488592,23086637,28648461,24686006,16153448,12094258,30453545,29356692,27116120,21079797,26944433,23242251,23624828,29150330,16951239,22944197,24886166,22552631,23475956,15515013,27502208,12531799,23155362,25946558,21542457,16273296,28109246,12556448,29563065,25284154,11126200,27863490,16465382,10954755,26700624,20846458,25382705,11731433,27062198,26582320,25923331,25825284,15897598,19322073,17200334,20384633,19513533,11867742,24344034,15574791,16343270,36215854,22270866,17276407,17486365,20582477,23754070,17289901,34809976,20009910,25960218,27761756,15020838,26264761,18310471,19270532,21889343,27292433,30091530,27587342,24615207,20856855,32650632,16026644,16476732,18413790,22994780,21615950,23354309,23365133,24023871,26050346,30583560,22322857,21067264,19639184,18025282,25922175,21637290,19295477,23868066,17654699,31120744,32046013,21037108,23964152,19889954,24712440,25073741,28167529,33023457,22373132,23286491,29807520,22456335,23469273,33125149,22711276,20460513,30868973,35283086,33557658,30944181,11703323,15738652,26752418,24800886,31269745,22154545,23867991,26219406,18549473,30307360,36867722,22868051,21184271,22458853,34321364,38683491,28506198,22493260,37467961,25479907,23744355,32495908,24092806,25119188,22425986,20512578,25166596,22928010,26839308,30606990,20957741,19291426,29024573,22669577,22894919,30537988,20676141,18097557,22327976,32653824,22322974,29393896,27821078,31766421,31215139,23042302,19801834,20679231,23940046,29215703,28646512,21721525,23089527,20167479,37753370,20652372,23549599,30070768,31374527,22995909,26713523,34319031,19421011,22965008,20145270,35807258,17876049,23626839,32534346,20503408,28043150,21718944,30963442,21255693,15356168,22260166,23888960,24381310,36633143,23221426,21762083,23588242,25393367,24084714,23221619,22848092,38981317,20739454,28267674,15809727,31414267,22313685,22279574,25824412,38261411,16928817,35514164,15738394,32535244,33743782,30563957,32290325,20142042,33255670,30192548,22494660,24912092,20816742,31285488,18000499,24231389,25140197,18683042,38488434,25228443,23147569,25695794,33572677,21931726,23977108,30059277,33974136,25220594,32321538,33433550,25963741,36224430,31451695,24603818,19447172,29313067,26258524,17121924,17121923,12769777,24172913,23258575,31516571,20878117,21726209,25275596,25063076,25040548,24722291,20561658,15161353,19860841,32993126,27324824,18606719,23992541,16585598,32998768,22922441,33360687,22306067,24030275,20450546,23888962,22223166,17962510,33300458,12770822,29613828,32615369,32455774,30878553,38202821,30828077,31456359,30465232,22441819,31206526,22140466,23686769,30188217,17606765,31883490,34445133,25126665,34066975,23061676,29959912,18838793,19239360,32878786,24880052,33847090,31892549,31672612,24844212,36549114,31014028,23764045,29190639,26698121,18347343,27039807,14741273,25169491,24032674,24651472,19445929,20855208,18408217,24351423,18271940,19509253,26118711,21949898,29384188,21695163,22041075,30745455,28042503,24793644,9501205,20164449,31431326,29386219,10922406,22249335,24584598,22302519,30529073,18217751,21933400,12576549,26082914,31037769,22647614,30958996,31675763,25546354,18374101,16645722,14744786,19759901,18839006,30997620,26898427,27041553,34156645,36306372,15908800,26601598,18568166,37572797,27267120,25579435,27367506,33788074,37975165,37300940,30851364,33126591,24037710,29531586,32006189,22083351,30923410,33745280,23269626,24460257,24079912,16861932,21878229,20039095,21278889,21454553,23590818,35917102,23918568,25782916,38820384,23567296,22957032,21135175,34463890,32234879,36732057,24707477,37660833,35797900,26286659,34959719,39384195,19639378,20180942,33938179,18060600,22161747,22326466,35342356,20654591,25618973,31016515,22749963,36644097,39053637,30634582,36126055,20458754,23449455,20663979,15283467,38893499,32431061,20863708,24728004,22384084,17030815,20053759,29905606,36576015,35501375,24039666,34641289,36200994,15863892,26557438,18424067,36870467,37116762,32893823,34068438,30423844,22508312,21497989,39146954,37958977,37190893,31724982,37569823,21253389,19324270,23542171,23636804,30197679,27747000,26636678,20117292,20882882,33867871,28123594,23923017,19459166,28119717,23925573,16093436,36077149,26184924,37371559,33021789,22336201,33677818,26095064,12678732,27385724,19885557,34730060,23889949,23894374,15026552,32336756,31915304,20599223,31540489,38382328,19362413,36876690,34884505,31476841,34081246,34443600,20053768,30672888,38853639,24040391,29622848,34638754,32480172,38447451,30710195,36442846,24236915,35635949,31480543,26000099,18541724,36346110,33125113,28337317,32088592,21174394,35591851,30109935,34572928,19515748,29526828,20682651,35802681,23725188,30818187,23930022,37647727,234039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Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells.

You BR, Han BR, Park WH. You BR, et al. Oncotarget. 2017 Mar 14;8(11):17726-17737. doi: 10.18632/oncotarget.14628. Oncotarget. 2017. PMID: 28099148 Free PMC article.

Suberoylanilide hydroxamic acid induces thioredoxin1-mediated apoptosis in lung cancer cells via up-regulation of miR-129-5p.

You BR, Park WH. You BR, et al. Mol Carcinog. 2017 Dec;56(12):2566-2577. doi: 10.1002/mc.22701. Epub 2017 Aug 3. Mol Carcinog. 2017. PMID: 28667779

Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation.

Imre G, Gekeler V, Leja A, Beckers T, Boehm M. Imre G, et al. Cancer Res. 2006 May 15;66(10):5409-18. doi: 10.1158/0008-5472.CAN-05-4225. Cancer Res. 2006. PMID: 16707469

Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.

You BR, Park WH. You BR, et al. Int J Oncol. 2014 May;44(5):1745-55. doi: 10.3892/ijo.2014.2337. Epub 2014 Mar 12. Int J Oncol. 2014. PMID: 24626405

Histone Deacetylase (HDAC) Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), Induces Apoptosis in Prostate Cancer Cell Lines via the Akt/FOXO3a Signaling Pathway.

Shi XY, Ding W, Li TQ, Zhang YX, Zhao SC. Shi XY, et al. Med Sci Monit. 2017 Dec 6;23:5793-5802. doi: 10.12659/msm.904597. Med Sci Monit. 2017. PMID: 29211704 Free PMC article.

A novel suberoylanilide hydroxamic acid histone deacetylase inhibitor derivative, N25, exhibiting improved antitumor activity in both human U251 and H460 cells.

Zhang S, Huang WB, Wu L, Wang LY, Ye LB, Feng BH. Zhang S, et al. Asian Pac J Cancer Prev. 2014;15(10):4331-8. doi: 10.7314/apjcp.2014.15.10.4331. Asian Pac J Cancer Prev. 2014. PMID: 24935393 Free article.

Anticancer effects of the MHY218 novel hydroxamic acid-derived histone deacetylase inhibitor in human ovarian cancer cells.

Jeon HS, Ahn MY, Park JH, Kim TH, Chun P, Kim WH, Kim J, Moon HR, Jung JH, Kim HS. Jeon HS, et al. Int J Oncol. 2010 Aug;37(2):419-28. doi: 10.3892/ijo_00000690. Int J Oncol. 2010. PMID: 20596669

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.

Chiu HW, Yeh YL, Wang YC, Huang WJ, Chen YA, Chiou YS, Ho SY, Lin P, Wang YJ. Chiu HW, et al. PLoS One. 2013 Oct 10;8(10):e76340. doi: 10.1371/journal.pone.0076340. eCollection 2013. PLoS One. 2013. PMID: 24130769 Free PMC article.

The levels of HDAC1 and thioredoxin1 are related to the death of mesothelioma cells by suberoylanilide hydroxamic acid.

You BR, Park WH. You BR, et al. Int J Oncol. 2016 May;48(5):2197-204. doi: 10.3892/ijo.2016.3402. Epub 2016 Feb 19. Int J Oncol. 2016. PMID: 26936390

Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics.

Zhou X, Yang XY, Popescu NC. Zhou X, et al. Int J Oncol. 2010 Apr;36(4):999-1005. doi: 10.3892/ijo_00000580. Int J Oncol. 2010. PMID: 20198346

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