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Year	Number of Results
2006	3
2007	3
2009	2
2010	3
2011	9
2012	8
2013	24
2014	16
2015	25
2016	35
2017	56
2018	68
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636 results

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Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer.

Wang L, Yang D, Tian J, Gao A, Shen Y, Ren X, Li X, Jiang G, Dong T. Wang L, et al. Oncotarget. 2017 Apr 18;8(16):26323-26333. doi: 10.18632/oncotarget.15461. Oncotarget. 2017. PMID: 28412748 Free PMC article.

Fibroblast activation protein-α in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways.

Cao F, Wang S, Wang H, Tang W. Cao F, et al. Mol Med Rep. 2018 Feb;17(2):2593-2599. doi: 10.3892/mmr.2017.8155. Epub 2017 Nov 27. Mol Med Rep. 2018. PMID: 29207091

Cancer-associated fibroblasts promote colorectal cancer progression by secreting CLEC3B.

Zhu HF, Zhang XH, Gu CS, Zhong Y, Long T, Ma YD, Hu ZY, Li ZG, Wang XY. Zhu HF, et al. Cancer Biol Ther. 2019;20(7):967-978. doi: 10.1080/15384047.2019.1591122. Epub 2019 Mar 20. Cancer Biol Ther. 2019. PMID: 30894065 Free PMC article.

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2.

Li M, Liu Y, Xia F, Wu Z, Deng L, Jiang R, Guo FJ. Li M, et al. Cell Signal. 2014 Jul;26(7):1539-48. doi: 10.1016/j.cellsig.2014.03.026. Epub 2014 Apr 1. Cell Signal. 2014. PMID: 24703938

Clinical implications of progranulin in gastric cancer and its regulation via a positive feedback loop involving AKT and ERK signaling pathways.

Yang D, Li R, Wang H, Wang J, Han L, Pan L, Li X, Kong Q, Wang G, Su X. Yang D, et al. Mol Med Rep. 2017 Dec;16(6):9685-9691. doi: 10.3892/mmr.2017.7796. Epub 2017 Oct 17. Mol Med Rep. 2017. PMID: 29039535

Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling.

Zhong B, Cheng B, Huang X, Xiao Q, Niu Z, Chen YF, Yu Q, Wang W, Wu XJ. Zhong B, et al. Cell Death Dis. 2021 Dec 20;13(1):16. doi: 10.1038/s41419-021-04461-6. Cell Death Dis. 2021. PMID: 34930899 Free PMC article.

Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway.

Dai G, Yao X, Zhang Y, Gu J, Geng Y, Xue F, Zhang J. Dai G, et al. Bull Cancer. 2018 Apr;105(4):336-349. doi: 10.1016/j.bulcan.2017.12.009. Epub 2018 Feb 26. Bull Cancer. 2018. PMID: 29496262

Oxaliplatin inhibits colorectal cancer progression by inhibiting CXCL11 secreted by cancer-associated fibroblasts and the CXCR3/PI3K/AKT pathway.

Lu C, Zhang C. Lu C, et al. Clin Transl Oncol. 2023 Jan;25(1):160-172. doi: 10.1007/s12094-022-02922-8. Epub 2022 Sep 21. Clin Transl Oncol. 2023. PMID: 36129606

Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.

Yang D, Wang LL, Dong TT, Shen YH, Guo XS, Liu CY, Liu J, Zhang P, Li J, Sun YP. Yang D, et al. Am J Cancer Res. 2015 Sep 15;5(10):3085-97. eCollection 2015. Am J Cancer Res. 2015. PMID: 26693061 Free PMC article.

PGRN promotes migration and invasion of epithelial ovarian cancer cells through an epithelial mesenchymal transition program and the activation of cancer associated fibroblasts.

Dong T, Yang D, Li R, Zhang L, Zhao H, Shen Y, Zhang X, Kong B, Wang L. Dong T, et al. Exp Mol Pathol. 2016 Feb;100(1):17-25. doi: 10.1016/j.yexmp.2015.11.021. Epub 2015 Dec 1. Exp Mol Pathol. 2016. PMID: 26607602

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