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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1999 1
2001 2
2002 1
2003 6
2004 7
2005 9
2006 8
2007 9
2008 4
2009 4
2010 11
2011 3
2012 2
2013 2
2014 6
2015 4
2016 3
2017 5
2018 3
2019 2
2020 0
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86 results
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Page 1
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists.
Palmer D, Gonçalves JPL, V Hansen L, Wu B, Hald H, Schoffelen S, Diness F, Le Quement ST, Nielsen TE, Meldal M. Palmer D, et al. J Med Chem. 2017 Nov 9;60(21):8716-8730. doi: 10.1021/acs.jmedchem.7b00353. Epub 2017 Oct 24. J Med Chem. 2017. PMID: 28972753
Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).
Singh A, Dirain ML, Wilczynski A, Chen C, Gosnell BA, Levine AS, Edison AS, Haskell-Luevano C. Singh A, et al. ACS Chem Neurosci. 2014 Oct 15;5(10):1020-31. doi: 10.1021/cn5000953. Epub 2014 Aug 26. ACS Chem Neurosci. 2014. PMID: 25141170 Free PMC article.
Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C. Wilczynski A, et al. J Med Chem. 2004 Apr 22;47(9):2194-207. doi: 10.1021/jm0303608. J Med Chem. 2004. PMID: 15084118
Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.
Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G. Molden BM, et al. Mol Endocrinol. 2015 Nov;29(11):1619-33. doi: 10.1210/me.2015-1071. Epub 2015 Sep 29. Mol Endocrinol. 2015. PMID: 26418335 Free PMC article.
γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R.
Joseph CG, Yao H, Scott JW, Sorensen NB, Marnane RN, Mountjoy KG, Haskell-Luevano C. Joseph CG, et al. Peptides. 2010 Dec;31(12):2304-13. doi: 10.1016/j.peptides.2010.08.025. Epub 2010 Sep 15. Peptides. 2010. PMID: 20833220 Free PMC article.
A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.
Hsiung HM, Hertel J, Zhang XY, Smith DP, Smiley DL, Heiman ML, Yang DD, Husain S, Mayer JP, Zhang L, Mo H, Yan LZ. Hsiung HM, et al. Endocrinology. 2005 Dec;146(12):5257-66. doi: 10.1210/en.2005-0177. Epub 2005 Sep 15. Endocrinology. 2005. PMID: 16166226
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