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30072583,29304823,28010732,30844369,22120905,12045208,20196079,14685680,27815074,24642258,20978149,24251807,11522744,30134915,31461190,24722208,24850830,24487055,18854359,27000756,31364752,12530096,18977219,32024448,30874550,22682247,29156563,23771323,36808265,19578404,17143297,19966865,28418912,26804172,25735981,11707154,14770182,20564245,33945535,23840886,18632633,22103048,31269945,29673457,31723073,23838596,30256815,19607815,27391059,38970018,28472810,11072519,30259713,26446593,28958640,14986031,15287021,28086904,11746989,24763434,16298038,12833148,16885356,28179481,17135276,27595705,19847890,27482906,29368261,9591632,11668620,26028359,17373666,24011952,30338942,9601641,25820106,14654913,23796566,32091625,12057910,33545120,37872280,30197296,34863211,10700176,27563825,30238564,24092877,10980114,36445120,33664379,26193883,14502807,28271271,33112876,15982419,32005247,27846906,22761442,20926645,21996741,22115830,31160382,11696422,34676872,32076059,22509309,34266857,31283021,24299953,36688401,18403596,18487207,25183641,33445154,27087319,31686521,15769611,34454113,12952568,31540078,31391772,32717306,16798748,25236910,24931405,15355978,29045831,21643010,37943618,23277359,27196752,18591935,35999641,25270420,37533857,22184111,24169521,34352208,18321998,17377531,25243319,24015932,32285989,22961697,32971322,34431598,38279052,24913975,31337618,28628110,31383941,14710233,20844082,30720232,33144683,35417240,22645652,34911816,31273221,32665357,10722668,32581014,31651566,30471109,32941008,23998936,29449169,38521200,29302705,34873211,24240237,11099951,22751121,36901686,20368985,10992298,34495485,32372448,24162018,23525311,30671715,27819675,24196627,39200196,33579312,23520519,20886217,30760710,32445578,19597346,35216222,25961913,39125758,33720402,21949247,36864485,22052467,37759479,32481626,37358225,32655835,39027989,35962368,23085758,22128170,18514389,22863622,30283086,22968731,33597597,18587328,26622826,32167488,22847197,30782412,17572842,33105836,30569497,30451837,18199528,30953362,18612695,19450512,37095033,28576136,24736844,26255203,26439805,10681434,18094611,23935526,16368566,32651460,30945380,26056602,23476634,30172912,30733598,36982759,37589277,24194897,28414304,31571923,31605540,32327666,25274627,25571954,35320710,18160396,31894264,36586069,33811251,27959917,35868288,31070915,30753902,37944015,31504825,32751567,31097693,33788735,22513088,25003333,36502525,33290799,31704613,21769429,16439994,35066101,36056393,12642683,32003827,26097888,22168384,22315403,18521697,34267890,20043299,33651074,17028196,38419282,31070935,37995618,34320348,35550340,30640173,33237836,36669491,25208568,28811361,25175604,23658527,23910005,31957856,38421454,17673467,20890287,35537038,31534175,31724259,31744909,23407966,19149881,23250421,37229318,23624843,22799487,23397547,31650683,26894286,35303016,32587772,32593708,34487537,36356835,20084116,23812285,25839957,26493106,24553287,36361804,21807601,19356224,23668310,33999013,26975665,20010873,15195113,24200292,34593610,37973999,16699180,33901189,38700077,33120354,34575971,24130866,18723878,30070321,9973276,24934177,27574554,36317213,35336965,30950765,30622113,31881079,23293720,21859464,24245549,38359148,29144570,21531761,33060621,33177648,19525225,25931827,30304392,35438040,21297660,32104224,18794146,32567731,32594830,20460455,32754865,23144924,27022656,27694902,24350795,29872723,29533772,33057364,29404451,11935128,37811860,20140201,20628379,38069408,19197353,30737831,17881494,16303851,38073344,32382323,26137160,31095674,21857949,38848383,26091037,33240893,31196256,27798265,19779968,33309767,28428272,22745173,30177831,37266046,19928354,31496624,35483008,28117551,34212311,38324534,29887948,30374053,27551464,33472091,33346022,1324739,34725446,18474248,24148210,31109112,23011394,34817745,30144514,24727894,24078348,19173296,35755812,35483122,35712511,31017675,29449562,36721985,18716166,21505584,30635339,32934706,22792392,23405266,22009253,22509369,18330950,24667635,18716223,32329863,35780585,31384200,38183076,38566304,23562608,27489864,26289750,21502812,28397687,33335067,25232400,26622584,31991021,28708826,34540977,21593603,21411865,35625868,18836487,38216082,27296949,26101583,19897489,25509301,32046432,38894812,30724425,22380946,22136118,35968980,29109117,33108070,33239858,26121046,29531269,35325837,33459525,36457029,22699938,17588722,38414697,35197279,30150766,34224960,38350393,21547505,18331993,37000474,25954663,34000297,23361301,36934880,30224629,37114476,32013702,29391809,34965835,19725988,26909336,22011079,30375302,38715121,34885156,24093640,20140021,21483657,34385594,24156781,28208209,23918447,23516639,31689969,25336178,36629695,31275360,35256667,34163569,16688812,27777639,38728213,38377966,31520998,31955867,31807167,29225578,12644054,29615557,20729907,32710739,18786926,33511474,39227904,34774804,30808659,36330477,32103169,37601671,38291457,18488710,25617745,31431458,26981430,28503404,25060218,20488884,31877462,33969134,29387236,27308333,34935584,28454231,24518971,24685131,24678719,20874049,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miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4.

Prossomariti A, Piazzi G, D'Angelo L, Miccoli S, Turchetti D, Alquati C, Montagna C, Bazzoli F, Ricciardiello L. Prossomariti A, et al. Mol Cancer Res. 2018 Dec;16(12):1965-1976. doi: 10.1158/1541-7786.MCR-18-0115. Epub 2018 Aug 2. Mol Cancer Res. 2018. PMID: 30072583 Free article.

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer.

Zhang Y, Guo L, Li Y, Feng GH, Teng F, Li W, Zhou Q. Zhang Y, et al. Mol Cancer. 2018 Jan 5;17(1):1. doi: 10.1186/s12943-017-0753-1. Mol Cancer. 2018. PMID: 29304823 Free PMC article.

The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells.

Yedid N, Kalma Y, Malcov M, Amit A, Kariv R, Caspi M, Rosin-Arbesfeld R, Ben-Yosef D. Yedid N, et al. BMC Cancer. 2016 Dec 23;16(1):952. doi: 10.1186/s12885-016-2809-9. BMC Cancer. 2016. PMID: 28010732 Free PMC article.

Down-regulation of microRNA-31-5p inhibits proliferation and invasion of osteosarcoma cells through Wnt/β-catenin signaling pathway by enhancing AXIN1.

Chen X, Zhong L, Li X, Liu W, Zhao Y, Li J. Chen X, et al. Exp Mol Pathol. 2019 Jun;108:32-41. doi: 10.1016/j.yexmp.2019.03.001. Epub 2019 Mar 4. Exp Mol Pathol. 2019. PMID: 30844369

Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis.

Hu PJ, Knoepp SM, Wu R, Cho KR. Hu PJ, et al. Genes Chromosomes Cancer. 2012 Mar;51(3):283-9. doi: 10.1002/gcc.20953. Epub 2011 Nov 25. Genes Chromosomes Cancer. 2012. PMID: 22120905 Free article.

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

Albuquerque C, Breukel C, van der Luijt R, Fidalgo P, Lage P, Slors FJ, Leitão CN, Fodde R, Smits R. Albuquerque C, et al. Hum Mol Genet. 2002 Jun 15;11(13):1549-60. doi: 10.1093/hmg/11.13.1549. Hum Mol Genet. 2002. PMID: 12045208

Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas.

Obrador-Hevia A, Chin SF, González S, Rees J, Vilardell F, Greenson JK, Cordero D, Moreno V, Caldas C, Capellá G. Obrador-Hevia A, et al. J Pathol. 2010 May;221(1):57-67. doi: 10.1002/path.2685. J Pathol. 2010. PMID: 20196079 Free article.

[Familial adenomatous polyposis syndrome (FAP): pathogenesis and molecular mechanisms].

Friedrich A, Kullmann F. Friedrich A, et al. Med Klin (Munich). 2003 Dec 15;98(12):776-82. doi: 10.1007/s00063-003-1325-2. Med Klin (Munich). 2003. PMID: 14685680 Review. German.

MicroRNA-106a-5p facilitates human glioblastoma cell proliferation and invasion by targeting adenomatosis polyposis coli protein.

Li D, Wang Z, Chen Z, Lin L, Wang Y, Sailike D, Luo K, Du G, Xiang X, Jiafu GD. Li D, et al. Biochem Biophys Res Commun. 2016 Dec 9;481(3-4):245-250. doi: 10.1016/j.bbrc.2016.10.132. Epub 2016 Nov 1. Biochem Biophys Res Commun. 2016. PMID: 27815074

Downregulation of adenomatous polyposis coli by microRNA-663 promotes odontogenic differentiation through activation of Wnt/beta-catenin signaling.

Kim JS, Park MG, Lee SA, Park SY, Kim HJ, Yu SK, Kim CS, Kim SG, Oh JS, You JS, Kim JS, Seo YS, Chun HS, Park JC, Kim DK. Kim JS, et al. Biochem Biophys Res Commun. 2014 Apr 18;446(4):894-900. doi: 10.1016/j.bbrc.2014.03.027. Epub 2014 Mar 15. Biochem Biophys Res Commun. 2014. PMID: 24642258

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