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30445013,17600122,26108453,36799463,22728872,26308055,24925797,32712019,38105754,25173753,31522982,32686913,30723922,32306539,37076961,17270507,31243614,36042192,36583714,31129431,33872692,29454797,26526716,27351144,34609282,32289375,23747755,25822023,27639079,31016646,22679000,28055006,28648950,18538673,28844951,37336290,31377883,34880414,37137833,29977037,24700364,28844960,35987275,20368698,23207146,1714872,8340058,27912077,30883752,38493927,27842214,30825315,21712022,9794910,30488488,26627606,27115285,9075660,36410025,25203810,31521820,29709678,30890428,28709963,32393417,10424289,28088462,29753567,34953958,10068199,26849025,28634212,31016659,28688656,26201095,30267710,33039404,29751359,23928400,25796361,34558852,28802066,29425397,28256736,17446175,10629565,10353011,31505038,23587498,37916976,23107486,8666687,32964473,30287339,17983805,11391535,28754453,9502419,30315770,26404950,37704824,22886419,29523685,38414587,30561764,37127664,31833071,15382127,18221819,32275903,30144553,27592379,20921947,31992593,25169977,17640975,27277679,37707950,15645536,21480331,28943450,25915403,17109383,33763888,34312700,20836156,28049044,36148647,35341737,30794890,19239726,35095853,36799446,31330051,7682020,22271822,36630995,36267871,17334411,18059363,24583060,31344280,29698570,39160386,30109019,33991110,19234136,12912866,39300174,33486744,9764987,38646644,28348230,33058867,20813968,10674028,26313562,28892096,23247798,24338559,31710124,30398152,12029638,31016667,35119514,37995866,28922472,22301700,30536089,20332524,31821710,38678809,37899786,31940841,19575365,31070797,35863741,30059007,9626763,11816546,32054995,26773039,30248340,29964040,34028753,37725754,27631617,20382701,35799467,21071507,26866350,1700614,32142732,32622933,15236191,25138774,8912155,31241979,21480329,25369740,35178659,24726754,21274883,36313114,37446187,37073611,38199298,34861115,33084932,34440841,16278592,33352965,24120911,22173288,32329946,22484119,25120786,28966239,30610845,23097189,24390753,32128842,24482234,37261338,9075662,10365812,20512997,29109128,33214166,21520179,25286440,34062960,28104292,30036520,37600495,9918904,32950589,21721031,12390471,29140564,22841787,22253789,39164890,29678444,8773910,30850822,21809484,21826054,37396159,22698400,29248458,24436140,38092141,36999531,9928763,31251081,18769938,12086915,17923499,32745270,30898581,21607140,37348790,30141207,34662704,39314550,29523787,25046437,17900655,10793072,16015684,30975574,16628643,32856740,38749218,29404503,35563897,11454187,17600123,34896545,37059338,15559365,30411082,19105206,8365711,28635176,29550924,31337842,29134411,36941658,2476370,35245467,32994489,33768568,38818402,36849079,18667695,9419599,31974352,32558183,21283681,34519176,37820623,37307826,29291351,17999420,12927921,33090557,30070383,8698195,37774670,21497742,11408017,33124779,21287200,7681137,13916728,25141347,34794182,26921287,34645984,11815289,34207442,38873613,36929584,3055807,21281779,33690095,31365294,38216052,34718050,37777319,33866021,35593740,28013213,32310045,22331132,19396955,1354635,18471524,35258491,17397517,32585307,26192438,38344767,31080135,36339578,34973373,37784089,9766825,24706750,36624475,38627596,34075171,11097474,22452290,12445169,19501526,14992427,36250997,36870530,24979510,22594800,15799977,34761065,11208728,37881074,21898507,19823170,19396964,32332110,22396550,2732447,37345655,20093230,38651949,38526652,31465556,19195939,37263345,31922706,24612866,19841618,30622832,34997170,29937200,19412431,8707960,10335364,22194419,19342479,10604574,6084160,38029740,36522162,34117597,38334601,3158582,30595544,32952871,18759007,36110848,35978523,32503996,30584802,38273071,36759512,31555647,36869985,38338338,15712659,36076599,28862262,10779363,18467658,31618101,12067295,16773708,39032102,38837539,12618883,35326489,31165788,25867762,19669308,35625945,37460023,33436050,31107443,24649166,30957303,21423008,26880950,22940098,31881915,10551390,27469900,31108103,36151109,38623945,7587779,27421703,24737165,25794352,17241889,22844556,37093429,30518128,29344161,33745829,39130146,39250501,35742868,37683035,14592665,32998669,36495019,35903109,7557869,32708712,32373615,37452426,35487218,34630404,31206736,20576918,23856906,4133273,25191532,38607018,34700031,8269849,25097819,39251168,32025608,32008745,803737,26844528,32587513,26473015,23880624,37997753,5028614,37088308,24592262,35180209,38993508,18560566,37605828,22878470,33627483,33987436,36876915,28865156,24683258,35726350,15703559,2215091,4350480,14084823,31591386,38606426,34440196,33267737,38129911,33756496,9250897,10726960,37047635,31247307,33480600,12808223,21350186,33918904,13998982,24570919,5756184,34337167,29796307,19711021,11454186,5081879,32039217,2411048,19533127,21607142,35521912,11474306,19208039,6672506,11789557,35572980,32411244,37078452,8353384,33227094,6725547,37814852,36324805,24359594,14802166,33786975,35992761,34088666,17033304,25754451,25056656,29552372,12576020,34047463,5132779,17031116,31855397,31887774,18047583,37465675,3967855,30901095,35245462,37456677,37554922,31645478,33602846,39189794,38377369,32839846,39378378,38889437,31042162,31042163,39014692[uid]

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571 results

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Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.

Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC. Elßner C, et al. Gastroenterology. 2019 Mar;156(4):1190-1205.e14. doi: 10.1053/j.gastro.2018.11.018. Epub 2018 Nov 13. Gastroenterology. 2019. PMID: 30445013

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.

Fickert P, Stöger U, Fuchsbichler A, Moustafa T, Marschall HU, Weiglein AH, Tsybrovskyy O, Jaeschke H, Zatloukal K, Denk H, Trauner M. Fickert P, et al. Am J Pathol. 2007 Aug;171(2):525-36. doi: 10.2353/ajpath.2007.061133. Epub 2007 Jun 28. Am J Pathol. 2007. PMID: 17600122 Free PMC article.

Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction.

Chen Y, Guldiken N, Spurny M, Mohammed HH, Haybaeck J, Pollheimer MJ, Fickert P, Gassler N, Jeon MK, Trautwein C, Strnad P. Chen Y, et al. J Pathol. 2015 Nov;237(3):343-54. doi: 10.1002/path.4580. Epub 2015 Aug 3. J Pathol. 2015. PMID: 26108453

P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases.

Zhang J, Lyu Z, Li B, You Z, Cui N, Li Y, Li Y, Huang B, Chen R, Chen Y, Peng Y, Fang J, Wang Q, Miao Q, Tang R, Gershwin ME, Lian M, Xiao X, Ma X. Zhang J, et al. Hepatology. 2023 Jul 1;78(1):10-25. doi: 10.1097/HEP.0000000000000317. Epub 2023 Feb 20. Hepatology. 2023. PMID: 36799463

Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.

Urbanik T, Boger RJ, Longerich T, Becker K, Ehrenberg KR, Hövelmeyer N, Hahn M, Schuchmann M, Jäger D, Waisman A, Wörns MA, Schulze-Bergkamen H. Urbanik T, et al. J Hepatol. 2012 Nov;57(5):995-1003. doi: 10.1016/j.jhep.2012.06.017. Epub 2012 Jun 21. J Hepatol. 2012. PMID: 22728872

Effects of Melittin Treatment in Cholangitis and Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice.

Kim KH, Sung HJ, Lee WR, An HJ, Kim JY, Pak SC, Han SM, Park KK. Kim KH, et al. Toxins (Basel). 2015 Aug 25;7(9):3372-87. doi: 10.3390/toxins7093372. Toxins (Basel). 2015. PMID: 26308055 Free PMC article.

Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.

Marzioni M, Agostinelli L, Candelaresi C, Saccomanno S, De Minicis S, Maroni L, Mingarelli E, Rychlicki C, Trozzi L, Banales JM, Benedetti A, Baroni GS. Marzioni M, et al. Hepatology. 2014 Oct;60(4):1324-35. doi: 10.1002/hep.27262. Epub 2014 Aug 25. Hepatology. 2014. PMID: 24925797

Knockout of the Tachykinin Receptor 1 in the Mdr2^-/- (Abcb4^-/-) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis.

Ceci L, Francis H, Zhou T, Giang T, Yang Z, Meng F, Wu N, Kennedy L, Kyritsi K, Meadows V, Wu C, Liangpunsakul S, Franchitto A, Sybenga A, Ekser B, Mancinelli R, Onori P, Gaudio E, Glaser S, Alpini G. Ceci L, et al. Am J Pathol. 2020 Nov;190(11):2251-2266. doi: 10.1016/j.ajpath.2020.07.007. Epub 2020 Jul 23. Am J Pathol. 2020. PMID: 32712019 Free PMC article.

Unraveling the complexities of fibrosis and ductular reaction in liver disease: pathogenesis, mechanisms, and therapeutic insights.

Marakovits C, Francis H. Marakovits C, et al. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C698-C706. doi: 10.1152/ajpcell.00486.2023. Epub 2023 Dec 18. Am J Physiol Cell Physiol. 2024. PMID: 38105754 Free PMC article. Review.

Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice.

Yoshida S, Ikenaga N, Liu SB, Peng ZW, Chung J, Sverdlov DY, Miyamoto M, Kim YO, Ogawa S, Arch RH, Schuppan D, Popov Y. Yoshida S, et al. Gastroenterology. 2014 Dec;147(6):1378-92. doi: 10.1053/j.gastro.2014.08.038. Epub 2014 Aug 28. Gastroenterology. 2014. PMID: 25173753

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