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1

Systemic absorption of intranasal corticosteroids may occur and can potentially affect the hypothalamic-pituitary-adrenal axis.

Kline GA, Symonds CJ, Holmes DT. Kline GA, et al. CMAJ. 2021 Mar 22;193(12):E426. doi: 10.1503/cmaj.78162. CMAJ. 2021. PMID: 33753368 Free PMC article. No abstract available.

2

The authors reply to: "Systemic absorption of intranasal corticosteroids may occur and can potentially affect the hypothalamic-pituitary-adrenal axis".

Sowerby LJ, Fowler J. Sowerby LJ, et al. CMAJ. 2021 Mar 22;193(12):E427. doi: 10.1503/cmaj.78206. CMAJ. 2021. PMID: 33753369 Free PMC article. No abstract available.

3

Impact of study design on the evaluation of inhaled and intranasal corticosteroids' effect on hypothalamic-pituitary-adrenal axis function.

Fan Y, Ma L, Pippins J, Limb S, Xu Y, Sahajwalla CG. Fan Y, et al. J Pharm Sci. 2014 Oct;103(10):2963-79. doi: 10.1002/jps.24089. Epub 2014 Aug 7. J Pharm Sci. 2014. PMID: 25103275 Review.

4

Impact of study design on the evaluation of inhaled and intranasal corticosteroids' effect on hypothalamic-pituitary-adrenal axis function, part I: general overview of HPA axis study design.

Fan Y, Ma L, Pippins J, Limb S, Xu Y, Sahajwalla CG. Fan Y, et al. J Pharm Sci. 2013 Oct;102(10):3513-27. doi: 10.1002/jps.23689. Epub 2013 Aug 5. J Pharm Sci. 2013. PMID: 23918409 Review.

5

Effects of intranasal corticosteroids on the hypothalamic-pituitary-adrenal axis in children.

Boner AL. Boner AL. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S32-9. doi: 10.1067/mai.2001.115564. J Allergy Clin Immunol. 2001. PMID: 11449204 Review.

6

Intranasal corticosteroids and adrenal suppression.

Bruni FM, De Luca G, Venturoli V, Boner AL. Bruni FM, et al. Neuroimmunomodulation. 2009;16(5):353-62. doi: 10.1159/000216193. Epub 2009 Jun 29. Neuroimmunomodulation. 2009. PMID: 19571596 Review.

7

Effects of glucocorticoids on the hypothalamic-pituitary-adrenal axis in children and adults.

Gulliver T, Eid N. Gulliver T, et al. Immunol Allergy Clin North Am. 2005 Aug;25(3):541-55, vii. doi: 10.1016/j.iac.2005.04.001. Immunol Allergy Clin North Am. 2005. PMID: 16054542 Review.

8

Effects of repeated once daily dosing of three intranasal corticosteroids on basal and dynamic measures of hypothalamic-pituitary-adrenal-axis activity.

Wilson AM, McFarlane LC, Lipworth BJ. Wilson AM, et al. J Allergy Clin Immunol. 1998 Apr;101(4 Pt 1):470-4. doi: 10.1016/S0091-6749(98)70354-9. J Allergy Clin Immunol. 1998. PMID: 9564799 Clinical Trial.

9

Safety and tolerability of treatments for allergic rhinitis in children.

Baena-Cagnani CE. Baena-Cagnani CE. Drug Saf. 2004;27(12):883-98. doi: 10.2165/00002018-200427120-00005. Drug Saf. 2004. PMID: 15366976 Review.

10

Hypothalamic-pituitary-adrenal axis suppression by inhaled or nasal corticosteroids in HIV-infected patients.

Besemer F, Kramers C, Brinkman K, Hermus ARMM, van Herwaarden AE, Burger DM. Besemer F, et al. Int J Clin Pharm. 2020 Apr;42(2):347-350. doi: 10.1007/s11096-020-00995-5. Epub 2020 Mar 5. Int J Clin Pharm. 2020. PMID: 32140912 Free PMC article.

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