Similar articles for PMID: 34848455

Year	Number of Results
1998	2
1999	1
2001	1
2002	1
2003	1
2005	1
2006	2
2007	1
2009	1
2010	3
2011	5
2012	6
2013	7
2014	9
2015	10
2016	13
2017	13
2018	10
2019	11
2020	11
2021	8
2022	1
2024	0

1

The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression.

Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Ohtori S, Yonemoto T. Kinoshita H, et al. Anticancer Res. 2021 Dec;41(12):6013-6021. doi: 10.21873/anticanres.15420. Anticancer Res. 2021. PMID: 34848455

2

The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression.

Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Ohtori S, Yonemoto T. Kinoshita H, et al. Anticancer Res. 2021 Oct;41(10):4947-4955. doi: 10.21873/anticanres.15308. Anticancer Res. 2021. PMID: 34593442

3

Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide.

Tan Y, Bi L, Zhang P, Wang F, Lin F, Ni W, Wu J, Jiang L. Tan Y, et al. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4765-73. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 25197347 Free PMC article.

4

The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma.

Baker AF, Dragovich T, Tate WR, Ramanathan RK, Roe D, Hsu CH, Kirkpatrick DL, Powis G. Baker AF, et al. J Lab Clin Med. 2006 Feb;147(2):83-90. doi: 10.1016/j.lab.2005.09.001. J Lab Clin Med. 2006. PMID: 16459166 Free PMC article. Clinical Trial.

5

Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines.

Wang F, Lin F, Zhang P, Ni W, Bi L, Wu J, Jiang L. Wang F, et al. Oncol Rep. 2015 Feb;33(2):967-73. doi: 10.3892/or.2014.3652. Epub 2014 Dec 5. Oncol Rep. 2015. PMID: 25483731

6

Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells.

Ehrenfeld V, Fulda S. Ehrenfeld V, et al. Biol Chem. 2020 Feb 25;401(2):273-283. doi: 10.1515/hsz-2019-0160. Biol Chem. 2020. PMID: 31352431

7

Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase.

Kim YH, Coon A, Baker AF, Powis G. Kim YH, et al. Cancer Chemother Pharmacol. 2011 Aug;68(2):405-13. doi: 10.1007/s00280-010-1500-0. Epub 2010 Nov 11. Cancer Chemother Pharmacol. 2011. PMID: 21069338 Free PMC article.

8

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.

Ramanathan RK, Abbruzzese J, Dragovich T, Kirkpatrick L, Guillen JM, Baker AF, Pestano LA, Green S, Von Hoff DD. Ramanathan RK, et al. Cancer Chemother Pharmacol. 2011 Mar;67(3):503-9. doi: 10.1007/s00280-010-1343-8. Epub 2010 May 12. Cancer Chemother Pharmacol. 2011. PMID: 20461382 Clinical Trial.

9

The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.

Jordan BF, Runquist M, Raghunand N, Gillies RJ, Tate WR, Powis G, Baker AF. Jordan BF, et al. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):529-36. Clin Cancer Res. 2005. PMID: 15701837

10

PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner.

You BR, Shin HR, Han BR, Park WH. You BR, et al. Tumour Biol. 2015 Mar;36(3):2087-95. doi: 10.1007/s13277-014-2816-x. Epub 2014 Nov 13. Tumour Biol. 2015. PMID: 25391429

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