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A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.
Reddy GR, Ueda N, Hada T, Sackeyfio AC, Yamamoto S, Hano Y, Aida M, Nomura T. Reddy GR, et al. Biochem Pharmacol. 1991 Jan 1;41(1):115-8. doi: 10.1016/0006-2952(91)90018-z. Biochem Pharmacol. 1991. PMID: 1986735
Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells.
Etti IC, Rasedee A, Hashim NM, Abdul AB, Kadir A, Yeap SK, Waziri P, Malami I, Lim KL, Etti CJ. Etti IC, et al. Drug Des Devel Ther. 2017 Mar 20;11:865-879. doi: 10.2147/DDDT.S124324. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 28356713 Free PMC article.