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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 3
2012 4
2013 4
2014 5
2015 5
2016 6
2017 5
2018 4
2019 6
2020 9
2021 6
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Cited In for PMID: 21746861

53 results
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The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann AC, Price RN, Wirjanata G, Noviyanti R, Tumwebaze P, Cooper RA, Rosenthal PJ, Sanz LM, Gamo FJ, Joseph J, Singh S, Bashyam S, Augereau JM, Giraud E, Bozec T, Vermat T, Tuffal G, Guillon JM, Menegotto J, Sallé L, Louit G, Cabanis MJ, Nicolas MF, Doubovetzky M, Merino R, Bessila N, Angulo-Barturen I, Baud D, Bebrevska L, Escudié F, Niles JC, Blasco B, Campbell S, Courtemanche G, Fraisse L, Pellet A, Fidock DA, Leroy D. Murithi JM, et al. Sci Transl Med. 2021 Jul 21;13(603):eabg6013. doi: 10.1126/scitranslmed.abg6013. Sci Transl Med. 2021. PMID: 34290058
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang W, Jayaseelan J, Katneni K, Patil R, Saunders J, Shahi SP, Chittimalla R, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Tumwebaze PK, Rosenthal PJ, Cooper RA, Aguiar ACC, Guido RVC, Pereira DB, Mittal N, Winzeler EA, Tomchick DR, Laleu B, Burrows JN, Rathod PK, Fidock DA, Charman SA, Phillips MA. Palmer MJ, et al. J Med Chem. 2021 May 13;64(9):6085-6136. doi: 10.1021/acs.jmedchem.1c00173. Epub 2021 Apr 20. J Med Chem. 2021. PMID: 33876936
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y, Will PM, Shah P, Sun H, Klumpp-Thomas C, Mok S, Yeo T, Meister S, Marugan JJ, Ross LS, Xu X, Maloney DJ, Jadhav A, Mott BT, Sciotti RJ, Winzeler EA, Waters NC, Campbell RF, Huang W, Simeonov A, Fidock DA. Dorjsuren D, et al. Sci Rep. 2021 Jan 22;11(1):2121. doi: 10.1038/s41598-021-81486-z. Sci Rep. 2021. PMID: 33483532 Free PMC article.
The Plasmodium falciparum eIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on parasite cell cycle.
Dias BKM, Nakabashi M, Alves MRR, Portella DP, Dos Santos BM, Costa da Silva Almeida F, Ribeiro RY, Schuck DC, Jordão AK, Garcia CRS. Dias BKM, et al. J Pineal Res. 2020 Oct;69(3):e12685. doi: 10.1111/jpi.12685. Epub 2020 Aug 7. J Pineal Res. 2020. PMID: 32702775 Free PMC article.
53 results