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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2014 1
2015 3
2016 6
2017 6
2018 2
2020 3
2021 1
2022 0
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Cited In for PMID: 25163684

21 results
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Page 1
Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.
Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, Hodder P. Pedró-Rosa L, et al. J Biomol Screen. 2015 Jan;20(1):122-30. doi: 10.1177/1087057114548832. Epub 2014 Aug 27. J Biomol Screen. 2015. PMID: 25163684 Free PMC article.
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.
Zhang Z, Barros-Álvarez X, Gillespie JR, Ranade RM, Huang W, Shibata S, Molasky NMR, Faghih O, Mushtaq A, Choy RKM, de Hostos E, Hol WGJ, Verlinde CLMJ, Buckner FS, Fan E. Zhang Z, et al. RSC Med Chem. 2020 May 18;11(8):885-895. doi: 10.1039/d0md00057d. eCollection 2020 Aug 1. RSC Med Chem. 2020. PMID: 33479683 Free PMC article.
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase.
Torrie LS, Robinson DA, Thomas MG, Hobrath JV, Shepherd SM, Post JM, Ko EJ, Ferreira RA, Mackenzie CJ, Wrobel K, Edwards DP, Gilbert IH, Gray DW, Fairlamb AH, De Rycker M. Torrie LS, et al. ACS Infect Dis. 2020 May 8;6(5):1044-1057. doi: 10.1021/acsinfecdis.9b00453. Epub 2020 Apr 28. ACS Infect Dis. 2020. PMID: 32275825 Free PMC article.
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Barros-Álvarez X, Turley S, Ranade RM, Gillespie JR, Duster NA, Verlinde CLMJ, Fan E, Buckner FS, Hol WGJ. Barros-Álvarez X, et al. Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):245-254. doi: 10.1107/S2053230X18003151. Epub 2018 Mar 28. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 29633973 Free PMC article.
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.
Torrie LS, Brand S, Robinson DA, Ko EJ, Stojanovski L, Simeons FRC, Wyllie S, Thomas J, Ellis L, Osuna-Cabello M, Epemolu O, Nühs A, Riley J, MacLean L, Manthri S, Read KD, Gilbert IH, Fairlamb AH, De Rycker M. Torrie LS, et al. ACS Infect Dis. 2017 Oct 13;3(10):718-727. doi: 10.1021/acsinfecdis.7b00047. Epub 2017 Oct 2. ACS Infect Dis. 2017. PMID: 28967262 Free PMC article.
21 results