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2015 6
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Cited In for PMID: 25875391

156 results

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Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.
Bora P, Zaman M, Oviedo S, Kutseikin S, Madrazo N, Mathur P, Pannikkat M, Krasny S, Aldakhlallah R, Chu A, Johnson KA, Grotjahn DA, Shutt TE, Wiseman RL. Bora P, et al. Proc Natl Acad Sci U S A. 2025 Dec 2;122(48):e2517552122. doi: 10.1073/pnas.2517552122. Epub 2025 Nov 25. Proc Natl Acad Sci U S A. 2025. PMID: 41289394 Free PMC article.
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.
Flores BN, Yu SB, Cohen IV, Fanok MH, Luan W, Maciuca RD, Sun LD, Tsai RM, Vissers M, Smits L, Bunte TM, Bakardjiev A, Balasundar S, Calvert MEK, Chin MY, Dobbins SK, Dowdle WE, Fang M, Heuberger JAAC, Ha CL, Huang F, Miyamoto T, Osipov M, Madrid San Martin L, Saund K, Tatarakis D, Vu AQ, Xiong C, Yeo GW, Groeneveld GJ, van den Berg LH, Dhuria S, Estrada AA, Jennings D, Sandmann T, Ho C, Scearce-Levie K, Yulyaningsih E, Walker AK, Di Paolo G, Kane LA, Troyer MD, Lewcock JW. Flores BN, et al. Nat Commun. 2025 Aug 18;16(1):7690. doi: 10.1038/s41467-025-63031-y. Nat Commun. 2025. PMID: 40825784 Free PMC article. Clinical Trial.
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells.
Bora P, Zaman M, Oviedo S, Kutseikin S, Madrazo N, Mathur P, Pannikkat M, Krasny S, Chu A, Johnson KA, Grotjahn DA, Shutt TE, Wiseman RL. Bora P, et al. bioRxiv [Preprint]. 2025 Jun 26:2025.06.23.660251. doi: 10.1101/2025.06.23.660251. bioRxiv. 2025. Update in: Proc Natl Acad Sci U S A. 2025 Dec 2;122(48):e2517552122. doi: 10.1073/pnas.2517552122. PMID: 40666974 Free PMC article. Updated. Preprint.
156 results