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Cited In for PMID: 34260228

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Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia.
Reichard HA, Schiffer HH, Monenschein H, Atienza JM, Corbett G, Skaggs AW, Collia DR, Ray WJ, Serrats J, Bliesath J, Kaushal N, Lam BP, Amador-Arjona A, Rahbaek L, McConn DJ, Mulligan VJ, Brice N, Gaskin PLR, Cilia J, Hitchcock S. Reichard HA, et al. J Med Chem. 2021 Aug 12;64(15):11527-11542. doi: 10.1021/acs.jmedchem.1c00820. Epub 2021 Jul 14. J Med Chem. 2021. PMID: 34260228
The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.
Hawkins PCT, Schwarz AJ, Stone JM, Pepper F, Gilleen J, Gijsen S, Mazibuko N, Arkilo D, Yin W, Wu J, Khudyakov P, Behrje R, Rosen L, Posener J, Mehta MA, Laurenza A. Hawkins PCT, et al. Psychopharmacology (Berl). 2026 Apr;243(4):819-829. doi: 10.1007/s00213-025-06884-x. Epub 2025 Aug 16. Psychopharmacology (Berl). 2026. PMID: 40817174 Free PMC article. Clinical Trial.
A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder: Results of the TERPSIS Study.
Benedetto SR, Ionescu A, Ge T, Furey M, Lin S, Jha MK, Krystal A, Shah AA, Walling DP, Shah N, Rizvi SJ, Kennedy S, Laurenza A, Murthy V, Roberts E, Singh JB. Benedetto SR, et al. J Clin Psychopharmacol. 2025 Sep-Oct 01;45(5):432-440. doi: 10.1097/JCP.0000000000002046. Epub 2025 Jul 28. J Clin Psychopharmacol. 2025. PMID: 40719142 Free PMC article. Clinical Trial.
13 results