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Cited In for PMID: 34791698

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C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
Licata NV, Cristofani R, Salomonsson S, Wilson KM, Kempthorne L, Vaizoglu D, D'Agostino VG, Pollini D, Loffredo R, Pancher M, Adami V, Bellosta P, Ratti A, Viero G, Quattrone A, Isaacs AM, Poletti A, Provenzani A. Licata NV, et al. EMBO J. 2022 Jan 4;41(1):e105026. doi: 10.15252/embj.2020105026. Epub 2021 Nov 18. EMBO J. 2022. PMID: 34791698 Free PMC article.
RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.
Webster CP, Hall B, Crossley OM, Dauletalina D, King M, Lin YH, Castelli LM, Yang ZL, Coldicott I, Kyrgiou-Balli E, Higginbottom A, Ferraiuolo L, De Vos KJ, Hautbergue GM, Shaw PJ, West RJ, Azzouz M. Webster CP, et al. Life Sci Alliance. 2024 Dec 5;8(2):e202402757. doi: 10.26508/lsa.202402757. Print 2025 Feb. Life Sci Alliance. 2024. PMID: 39638345 Free PMC article.
Multiple roles for the cytoskeleton in ALS.
Liu X, Henty-Ridilla JL. Liu X, et al. Exp Neurol. 2022 Sep;355:114143. doi: 10.1016/j.expneurol.2022.114143. Epub 2022 Jun 14. Exp Neurol. 2022. PMID: 35714755 Free PMC article. Review.
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