Clinical features of systemic lupus erythematosus patients with splenomegaly: focussed on the cytopenias

So Hye Nam; Han-Seung Park; Soo Min Ahn; Ji Seon Oh; Yong-Gil Kim; Chang-Keun Lee; Bin Yoo; Seokchan Hong

doi:10.1111/imj.16290

Clinical features of systemic lupus erythematosus patients with splenomegaly: focussed on the cytopenias

Intern Med J. 2023 Dec;53(12):2341-2345. doi: 10.1111/imj.16290.

Authors

So Hye Nam¹, Han-Seung Park², Soo Min Ahn³, Ji Seon Oh⁴, Yong-Gil Kim³, Chang-Keun Lee³, Bin Yoo³, Seokchan Hong³

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea.
² Division of Hematology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
³ Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
⁴ Department of Information Medicine, Big Data Research Center, Asan Medical Center, Seoul, South Korea.

PMID: 38130048
DOI: 10.1111/imj.16290

Abstract

This study aimed to investigate the clinical features of splenomegaly, mainly focussing on cytopenia, in patients with systemic lupus erythematosus (SLE). Cytopenia was commonly observed in 111 SLE patients with splenomegaly (n = 79, 71.2%). During the follow-up period, two patients developed haematologic malignancy after the diagnosis of SLE and splenomegaly, but no patients experienced severe complications (e.g. splenic rupture) related to splenomegaly.

Keywords: cytopenia; haematologic malignancy; splenomegaly; systemic lupus erythematosus.

MeSH terms

Cytopenia*
Hematologic Neoplasms* / complications
Humans
Lupus Erythematosus, Systemic* / complications
Lupus Erythematosus, Systemic* / diagnosis
Splenomegaly / diagnostic imaging
Splenomegaly / etiology

Grants and funding

2023IP0031-1/Asan Institute for Life Sciences, Asan Medical Center