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Year Number of Results
1987 1
1994 1
1998 2
2001 1
2003 1
2004 4
2005 3
2006 4
2007 2
2008 2
2009 1
2010 4
2011 2
2012 5
2013 6
2014 4
2015 4
2016 2
2017 3
2018 7
2019 4
2020 4
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Dynamics of a Protein Chain Motor Driving Helical Bacteria under Stress.
Roth J, Koch MD, Rohrbach A. Roth J, et al. Biophys J. 2018 Apr 24;114(8):1955-1969. doi: 10.1016/j.bpj.2018.02.043. Biophys J. 2018. PMID: 29694872 Free PMC article.
We developed a mechanistic, mathematical model based on Kramer's rates, describing the subsequent cooperative and conformational switching of the chain's proteins. ...To understand or even rebuild them, it is essential to reveal the molecular mechanism …
We developed a mechanistic, mathematical model based on Kramer's rates, describing the subsequent cooperative and conformational s
Clinical, genetic and neuropathological characterization of spinocerebellar ataxia type 37.
Corral-Juan M, Serrano-Munuera C, Rábano A, Cota-González D, Segarra-Roca A, Ispierto L, Cano-Orgaz AT, Adarmes AD, Méndez-Del-Barrio C, Jesús S, Mir P, Volpini V, Alvarez-Ramo R, Sánchez I, Matilla-Dueñas A. Corral-Juan M, et al. Brain. 2018 Jul 1;141(7):1981-1997. doi: 10.1093/brain/awy137. Brain. 2018. PMID: 29939198
We previously reported a novel spinocerebellar ataxia type subtype, SCA37, linked to an 11-Mb genomic region on 1p32, in a large Spanish ataxia pedigree characterized by ataxia and a pure cerebellar syndrome distinctively presenting with early-altered vertical eye movement …
We previously reported a novel spinocerebellar ataxia type subtype, SCA37, linked to an 11-Mb genomic region on 1p32, in a large Spanish ata …
An optical switch for a motor protein.
Li X, Kapoor TM. Li X, et al. Chembiochem. 2011 Oct 17;12(15):2265-6. doi: 10.1002/cbic.201100439. Chembiochem. 2011. PMID: 23106075 Free PMC article.
Light-triggered motor: Incorporation of a photocleavable group onto a phosphoserine residue of the regulator of a motor protein allows light-induced activation with spatial and temporal precision inside a living cell....
Light-triggered motor: Incorporation of a photocleavable group onto a phosphoserine residue of the regulator of a motor pro
Allosteric control of an ionotropic glutamate receptor with an optical switch.
Volgraf M, Gorostiza P, Numano R, Kramer RH, Isacoff EY, Trauner D. Volgraf M, et al. Nat Chem Biol. 2006 Jan;2(1):47-52. doi: 10.1038/nchembio756. Epub 2005 Dec 11. Nat Chem Biol. 2006. PMID: 16408092 Free PMC article.
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. ... …
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory bi …
Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations.
Ma Q, Sowa Y, Baker MA, Bai F. Ma Q, et al. Biophys J. 2016 Mar 29;110(6):1411-20. doi: 10.1016/j.bpj.2016.02.023. Biophys J. 2016. PMID: 27028650 Free PMC article.
It also predicts that the switching sensitivity of the BFM can be fine-tuned by incorporating additional units into the switch complex, as recently demonstrated by Yuan et al., who showed that stoichiometry of FliM undergoes dynamic change to maintain ultrasensitivi …
It also predicts that the switching sensitivity of the BFM can be fine-tuned by incorporating additional units into the switch
Core-Shell-Shell Upconversion Nanoparticles with Enhanced Emission for Wireless Optogenetic Inhibition.
Lin X, Chen X, Zhang W, Sun T, Fang P, Liao Q, Chen X, He J, Liu M, Wang F, Shi P. Lin X, et al. Nano Lett. 2018 Feb 14;18(2):948-956. doi: 10.1021/acs.nanolett.7b04339. Epub 2018 Jan 2. Nano Lett. 2018. PMID: 29278506
Recent advances in upconversion technology have enabled optogenetic neural stimulation using remotely applied optical signals, but limited success has been demonstrated for neural inhibition by using this method, primarily due to the much higher optical power and mo …
Recent advances in upconversion technology have enabled optogenetic neural stimulation using remotely applied optical signals, but li …
Mg2+ -free ATP regulates the processivity of native cytoplasmic dynein.
Behrens VA, Walter WJ, Peters C, Wang T, Brenner B, Geeves MA, Scholz T, Steffen W. Behrens VA, et al. FEBS Lett. 2019 Feb;593(3):296-307. doi: 10.1002/1873-3468.13319. Epub 2019 Jan 3. FEBS Lett. 2019. PMID: 30575960 Free article.
Cytoplasmic dynein, a microtubule-based motor protein, is responsible for many cellular functions ranging from cargo transport to cell division. ...A possible pathway to regulate motor function was revealed in optical trap experiments. Switching
Cytoplasmic dynein, a microtubule-based motor protein, is responsible for many cellular functions ranging from cargo transport …
Switching and Torque Generation in Swarming E. coli.
Ford KM, Antani JD, Nagarajan A, Johnson MM, Lele PP. Ford KM, et al. Front Microbiol. 2018 Sep 18;9:2197. doi: 10.3389/fmicb.2018.02197. eCollection 2018. Front Microbiol. 2018. PMID: 30279682 Free PMC article.
The switch enables reversals between clockwise (CW) and counterclockwise (CCW) directions of rotation of the flagellar motor. ...These results hint toward a possibility that the conformational dynamics of switch proteins play a role in the proper assem …
The switch enables reversals between clockwise (CW) and counterclockwise (CCW) directions of rotation of the flagellar motor. …
A "Driver Switchover" Mechanism of Influenza Virus Transport from Microfilaments to Microtubules.
Zhang LJ, Xia L, Liu SL, Sun EZ, Wu QM, Wen L, Zhang ZL, Pang DW. Zhang LJ, et al. ACS Nano. 2018 Jan 23;12(1):474-484. doi: 10.1021/acsnano.7b06926. Epub 2017 Dec 15. ACS Nano. 2018. PMID: 29232101
But how viruses switch from the actin roadway to the microtubule highway remains obscure. To settle this issue, we systematically dissected the role of related motor proteins in the transport of influenza virus between cytoskeletal filaments in situ and in re …
But how viruses switch from the actin roadway to the microtubule highway remains obscure. To settle this issue, we systematically dis …
Supported Solid Lipid Bilayers as a Platform for Single-Molecule Force Measurements.
Sudhakar S, Jachowski TJ, Kittelberger M, Maqbool A, Hermsdorf GL, Abdosamadi MK, Schäffer E. Sudhakar S, et al. Nano Lett. 2019 Dec 11;19(12):8877-8886. doi: 10.1021/acs.nanolett.9b03761. Epub 2019 Nov 26. Nano Lett. 2019. PMID: 31746618
For the latter, examples include the translocation of kinesin motor proteins along microtubule cytoskeletal filaments or the study of DNA-protein interactions. ...Furthermore, using a heating laser, we could switch the SSLB to its fluid state allowing …
For the latter, examples include the translocation of kinesin motor proteins along microtubule cytoskeletal filaments or the s …
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