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The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
He M, Subramanian R, Bangs F, Omelchenko T, Liem KF Jr, Kapoor TM, Anderson KV. He M, et al. Nat Cell Biol. 2014 Jul;16(7):663-72. doi: 10.1038/ncb2988. Epub 2014 Jun 22. Nat Cell Biol. 2014. PMID: 24952464 Free PMC article.
Mammalian Hedgehog (Hh) signal transduction requires a primary cilium, a microtubule-based organelle, and the Gli-Sufu complexes that mediate Hh signalling, which are enriched at cilia tips. Kif7, a kinesin-4 f
Mammalian Hedgehog (Hh) signal transduction requires a primary cilium, a microtubule-based organelle, and
Kif7 keeps cilia tips in shape.
Pedersen LB, Akhmanova A. Pedersen LB, et al. Nat Cell Biol. 2014 Jul;16(7):623-5. doi: 10.1038/ncb2997. Nat Cell Biol. 2014. PMID: 24981634
The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. ...Such Kif7-mediated organization of the ciliary tip
The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammal
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