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Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology.
Han J, Jun Y, Kim SH, Hoang HH, Jung Y, Kim S, Kim J, Austin RH, Lee S, Park S. Han J, et al. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14283-14288. doi: 10.1073/pnas.1614898113. Epub 2016 Nov 22. Proc Natl Acad Sci U S A. 2016. PMID: 27911816 Free PMC article.
This ecology of a fragmented metapopulation induced the drug resistance in stage IV U87 glioblastoma cells to doxorubicin in 7 d. Exome and transcriptome sequencing of the resistant cells identified mutations and differentially exp …
This ecology of a fragmented metapopulation induced the drug resistance in stage IV U87 glioblastoma cells to doxorubicin in 7 …
Using transcriptome sequencing to identify mechanisms of drug action and resistance.
Wacker SA, Houghtaling BR, Elemento O, Kapoor TM. Wacker SA, et al. Nat Chem Biol. 2012 Feb 12;8(3):235-7. doi: 10.1038/nchembio.779. Nat Chem Biol. 2012. PMID: 22327403 Free PMC article.
Determining mechanisms of drug action in human cells remains a major challenge. Here we describe an approach in which multiple-drug-resistant clones are isolated and transcriptome sequencing is used to find mutations in each clone. …
Determining mechanisms of drug action in human cells remains a major challenge. Here we describe an approach in which m …
Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.
Patel RK, Weir MC, Shen K, Snyder D, Cooper VS, Smithgall TE. Patel RK, et al. PLoS One. 2019 Dec 2;14(12):e0225887. doi: 10.1371/journal.pone.0225887. eCollection 2019. PLoS One. 2019. PMID: 31790499 Free PMC article.
Conversely, Hck and Fgr mutants with engineered A-419259 resistance mutations decreased sensitivity of TF-1/Flt3-ITD cells. To investigate de novo resistance mechanisms, A-419259-resistant Flt3-ITD+ AML cell populations were derived via long-term dose …
Conversely, Hck and Fgr mutants with engineered A-419259 resistance mutations decreased sensitivity of TF-1/Flt3-ITD cells. To invest …
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.
Shay JW, Homma N, Zhou R, Naseer MI, Chaudhary AG, Al-Qahtani M, Hirokawa N, Goudarzi M, Fornace AJ Jr, Baeesa S, Hussain D, Bangash M, Alghamdi F, Schulten HJ, Carracedo A, Khan I, Qashqari H, Madkhali N, Saka M, Saini KS, Jamal A, Al-Maghrabi J, Abuzenadah A, Chaudhary A, Al Qahtani M, Damanhouri G, Alkhatabi H, Goodeve A, Crookes L, Niksic N, Beauchamp N, Abuzenadah AM, Vaught J, Budowle B, Assidi M, Buhmeida A, Al-Maghrabi J, Buhmeida A, Assidi M, Merdad L, Kumar S, Miura S, Gomez K, Carracedo A, Rasool M, Rebai A, Karim S, Eldin HFN, Abusamra H, Alhathli EM, Salem N, Al-Qahtani MH, Kumar S, Faheem H, Agarwa A, Nieschlag E, Wistuba J, Damm OS, Beg MA, Abdel-Meguid TA, Mosli HA, Bajouh OS, Abuzenadah AM, Al-Qahtani MH, Coskun S, Abu-Elmagd M, Buhmeida A, Dallol A, Al-Maghrabi J, Hakamy S, Al-Qahtani W, Al-Harbi A, Hussain S, Assidi M, Al-Qahtani M, Abuzenadah A, Ozkosem B, DuBois R, Messaoudi SS, Dandana MT, Mahjoub T, Almawi WY, Abdalla S, Al-Aama MN, Elzawahry A, Takahashi T, Mimaki S, Furukawa E, Nakatsuka R, Kurosaka I, Nishigaki T, Nakamura H, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M, Mehmood S, Ashraf NM, Asif A, Bilal M, Mehmood MS, Hussain A, Jamal QMS, Siddiqui MU, Alzohairy MA, Al Karaawi MA, Nedjadi T, Al-Maghrabi J, Assidi M, Al-Khattabi H, Al-Ammari A, Al-Sayyad A, Buhmeida A, Al-Qahtani M, Zitouni H, Raguema N, Ali MB, Malah W, Lfalah R, Almawi W, Mahjoub T, Elanbari M, Ptitsyn A, Mahjoub S, El Ghali R, Achour B, Amor NB, Assidi M, N’siri B, Morjani H, Nedjadi T, Al-Ammari A, Al-Sayyad A, Salem N, Azhar E, Al-Maghrabi J, Chayeb V, Dendena M, Zitouni H, Zouari-Limayem K, Mahjoub T, Refaat B, Ashshi AM, Batwa SA, Ramadan H, Awad A, Ateya A, El-Shemi AGA, Ashshi A, Basalamah M, Na Y, Yun CO, El-Shemi AGA, Ashshi A, Basalamah M, Na Y, Yun CO, El-Shemi AG, Refaat B, Kensara O, Abdelfattah A, Dheeb BI, Al-Halbosiy MMF, Al lihabi RK, Khashman BM, Laiche D, Adeel C, Taoufik N, Al-Afghani H, Łastowska M, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CPF, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS, Singh M, Mansuri MS, Jadeja SD, Patel H, Marfatia YS, Begum R, Mohamed AM, Kamel AK, Helmy NA, Hammad SA, Kayed HF, Shehab MI, El Gerzawy A, Ead MM, Ead OM, Mekkawy M, Mazen I, El-Ruby M, Shahid SMA, Jamal QMS, Arif JM, Lohani M, Imen M, Leila C, Houyem O, Kais D, Fethi CDM, Mohamed B, Salem A, Faggad A, Gebreslasie AT, Zaki HY, Abdalla BE, AlShammari MS, Al-Ali R, Al-Balawi N, Al-Enazi M, Al-Muraikhi A, Busaleh F, Al-Sahwan A, Borgio F, Sayyed A, Al-Ali A, Acharya S, Zaki MS, El-Bassyouni HT, Shehab MI, Elshal MF, M. K, Aldahlawi AM, Saadah O, McCoy JP, El-Tarras AE, Awad NS, Alharthi AA, Ibrahim MMM, Alsehli HS, Dallol A, Gari AM, Abbas MM, Kadam RA, Gari MM, Alkaff MH, Abuzenadah AM, Gari MA, Abusamra H, Karim S, eldin HFN, Alhathli EM, Salem N, Kumar S, Al-Qahtani MH, Moradi FA, Rashidi OM, Awan ZA, Kaya IH, Al-Harazi O, Colak D, Alkousi NA, Athanasopoulos T, Bahmaid AO, Alhwait EA, Gari MA, Alsehli HS, Abbas MM, Alkaf MH, Kadam R, Dallol A, Kalamegam G, Eldin HFN, Karim S, Abusamra H, Alhathli E, Salem N, Al-Qahtani MH, Kumar S, Alsayed SN, Aljohani FH, Habeeb SM, Almashali RA, Basit S, Ahmed SM, Sharma R, Agarwal A, Durairajanayagam D, Samanta L, Abu-Elmagd M, Abuzenadah AM, Sabanegh ES, Assidi M, Al-Qahtani M, Agarwal A, Sharma R, Samanta L, Durairajanayagam D, Assidi M, Abu-Elmagd M, Al-Qahtani M, Abuzenadah AM, Sabanegh ES, Samanta L, Agarwal A, Sharma R, Cui Z, Assidi M, Abuzenadah AM, Abu-Elmagd M, Al-Qahtani M, Alboogmi AA, Alansari NA, Al-Quaiti MM, Ashgan FT, Bandah A, Jamal HS, Rozi A, Mirza Z, Abuzenadah AM, Karim S, Al-Qahtani MH, Karim S, Schulten HJ, Al Sayyad AJ, Farsi HMA, Al-Maghrabi JA, Mirza Z, Alotibi R, Al-Ahmadi A, Alansari NA, Albogmi AA, Al-Quaiti MM, Ashgan FT, Bandah A, Al-Qahtani MH, Ebiya RA, Darwish SM, Montaser MM, Abusamra H, Bajic VB, Al-Maghrabi J, Gomaa W, Hanbazazh M, Al-Ahwal M, Al-Harbi A, Al-Qahtani W, Hakamy S, Baba G, Buhmeida A, Al-Qahtani M, Al-Maghrabi J, Al-Harbi A, Al-Ahwal M, Al-Harbi A, Al-Qahtani W, Hakamy S, Baba G, Buhmeida A, Al-Qahtani M, Alhathli EM, Karim S, Salem N, Eldin HN, Abusamra H, Kumar S, Al-Qahtani MH, Alyamani AA, Kalamegam G, Alhwait EA, Gari MA, Abbas MM, Alkaf MH, Alsehli HS, Kadam RA, Al-Qahtani M, Gadi R, Buhmeida A, Assidi M, Chaudhary A, Merdad L, Alfakeeh SM, Alhwait EA, Gari MA, Abbas MM, Alkaf MH, Alsehli HS, Kadam R, Kalamegam G, Ghazala R, Mathew S, Hamed MH, Assidi M, Al-Qahtani M, Qadri I, Mathew S, Mira L, Shaabad M, Hussain S, Assidi M, Abu-Elmagd M, Al-Qahtani M, Mathew S, Shaabad M, Mira L, Hussain S, Assidi M, Abu-Elmagd M, Al-Qahtani M, Rebai A, Assidi M, Buhmeida A, Abu-Elmagd M, Dallol A, Shay JW, Almutairi MH, Ambers A, Churchill J, King J, Stoljarova M, Gill-King H, Assidi M, Abu-Elmagd M, Buhmeida A, Al-Qatani M, Budowle B, Abu-Elmagd M, Ahmed F, Dallol A, Assidi M, Almagd TA, Hakamy S, Agarwal A, Al-Qahtani M, Abuzenadah A, Karim S, Schulten HJ, Al Sayyad AJ, Farsi HMA, Al-Maghrabi JA, Buhmaida A, Mirza Z, Alotibi R, Al-Ahmadi A, Alansari NA, Albogmi AA, Al-Quaiti MM, Ashgan FT, Bandah A, Al-Qahtani MH, Satar R, Rasool M, Ahmad W, Nazam N, Lone MI, Naseer MI, Jamal MS, Zaidi SK, Pushparaj PN, Jafri MA, Ansari SA, Alqahtani MH, Bashier H, Al Qahtani A, Mathew S, Nour AM, Alkhatabi H, Zenadah AMA, Buhmeida A, Assidi M, Al Qahtani M, Faheem M, Mathew S, Mathew S, Pushparaj PN, Al-Qahtani MH, Alhadrami HA, Dallol A, Abuzenadah A, Hussein IR, Chaudhary AG, Bader RS, Bassiouni R, Alquaiti M, Ashgan F, Schulten H, Alama MN, Al Qahtani MH, Lone MI, Nizam N, Ahmad W, Jafri MA, Rasool M, Ansari SA, Al-Qahtani MH, Alshihri E, Abu-Elmagd M, Alharbi L, Assidi M, Al-Qahtani M, Mathew S, Natesan PP, Al Qahtani M, Kalamegam G, Pushparaj PN, Khan F, Kadam R, Ahmed F, Assidi M, Sait KHW, Anfinan N, Al Qahtani M, Naseer MI, Chaudhary AG, Jamal MS, Mathew S, Mira LS, Pushparaj PN, Ansari SA, Rasool M, AlQahtani MH, Naseer MI, Chaudhary AG, Mathew S, Mira LS, Jamal MS, Sogaty S, Bassiouni RI, Rasool M, AlQahtani MH, Rasool M, Ansari SA, Jamal MS, Pushparaj PN, Sibiani AMS, Ahmad W, Buhmeida A, Jafri MA, Warsi MK, Naseer MI, Al-Qahtani MH, Rubi, Kumar K, Naqvi AAT, Ahmad F, Hassan MI, Jamal MS, Rasool M, AlQahtani MH, Ali A, Jarullah J, Rasool M, Buhmeida A, Khan S, Abdussami G, Mahfooz M, Kamal MA, Damanhouri GA, Jamal MS, Jarullah B, Jarullah J, Jarullah MSS, Ali A, Rasool M, Jamal MS, Assidi M, Abu-Elmagd M, Bajouh O, Pushparaj PN, Al-Qahtani M, Abuzenadah A, Jamal MS, Jarullah J, Mathkoor AEA, Alsalmi HMA, Oun AMM, Damanhauri GA, Rasool M, AlQahtani MH, Naseer MI, Rasool M, Sogaty S, Chudhary AG, Abutalib YA, Merico D, Walker S, Marshall CR, Zarrei M, Scherer SW, Al-Qahtani MH, Naseer MI, Faheem M, Chaudhary AG, Rasool M, Kalamegam G, Ashgan FT, Assidi M, Ahmed F, Zaidi SK, Jan MM, Al-Qahtani MH, Al-Zahrani M, Lary S, Hakamy S, Dallol A, Al-Ahwal M, Al-Maghrabi J, Dermitzakis E, Abuzenadah A, Buhmeida A, Al-Qahtani M, Al-refai AA, Saleh M, Yassien RI, Kamel M, Habeb RM, Filimban N, Dallol A, Ghannam N, Al-Qahtani M, Abuzenadah AM, Bibi F, Akhtar S, Azhar EI, Yasir M, Nasser MI, Jiman-Fatani AA, Sawan A, Lahzah RA, Ali A, Hassan SA, Hasnain SE, Tayubi IA, Abujabal HA, Magrabi AO, Khan F, Kalamegam G, Pushparaj PN, Abuzenada A, Kumosani TA, Barbour E, Al-Qahtani M, Shabaad M, Mathew S, Dallol A, Merdad A, Buhmeida A, Al-Qahtani M, Assidi M, Abu-Elmagd M, Gauthaman K, Gari M, Chaudhary A, Abuzenadah A, Pushparaj PN, Al-Qahtani M, Hassan SA, Tayubi IA, Aljahdali HMA, Al Nono R, Gari M, Alsehli H, Ahmed F, Abbas M, Kalamegam G, Al-Qahtani M, Mathew S, Khan F, Rasool M, Jamal MS, Naseer MI, Mirza Z, Karim S, Ansari S, Assidi M, Kalamegam G, Gari M, Chaudhary A, Abuzenadah A, Pushparaj PN, Al-Qahtani M, Abu-Elmagd M, Kalamegam G, Kadam R, Alghamdi MA, Shamy M, Costa M, Khoder MI, Assidi M, Pushparaj PN, Gari M, Al-Qahtani M, Kharrat N, Belmabrouk S, Abdelhedi R, Benmarzoug R, Assidi M, Al Qahtani MH, Rebai A, Dhamanhouri G, Pushparaj PN, Noorwali A, Alwasiyah MK, Bahamaid A, Alfakeeh S, Alyamani A, Alsehli H, Abbas M, Gari M, Mobasheri A, Kalamegam G, Al-Qahtani M, Faheem M, Mathew S, Pushparaj PN, Al-Qahtani MH, Mathew S, Faheem M, Mathew S, Pushparaj PN, Al-Qahtani MH, Jamal MS, Zaidi SK, Khan R, Bhatia K, Al-Qahtani MH, Ahmad S, AslamTayubi I, Tripathi M, Hassan SA, Shrivastava R, Tayubi IA, Hassan S, Abujabal HAS, Shah I, Jarullah B, Jamal MS, Jarullah J, Sheikh IA, Ahmad E, Jamal MS, Rehan M, Abu-Elmagd M, Tayubi IA, AlBasri SF, Bajouh OS, Turki RF, Abuzenadah AM, Damanhouri GA, Beg MA, Al-Qahtani M, Hammoudah SAF, AlHarbi KM, El-Attar LM, Darwish AMZ, Ibrahim SM, Dallol A, Choudhry H, Abuzenadah A, Awlia J, Chaudhary A, Ahmed F, Al-Qahtani M, Jafri MA, Abu-Elmagd M, Assidi M, Al-Qahtani M, khan I, Yasir M, Azhar EI, Al-basri S, Barbour E, Kumosani T, Khan F, Kalamegam G, Pushparaj PN, Abuzenada A, Kumosani TA, Barbour E, EL Sayed HM, Hafez EA, Schulten HJ, Elaimi AH, Hussein IR, Bassiouni RI, Alwasiyah MK, Wintle RF, Chaudhary A, Scherer SW, Al-Qahtani M, Mirza Z, Pillai VG, Karim S, Sharma S, Kaur P, Srinivasan A, Singh TP, Al-Qahtani M, Alotibi R, Al-Ahmadi A, Al-Adwani F, Hussein D, Karim S, Al-Sharif M, Jamal A, Al-Ghamdi F, Al-Maghrabi J, Baeesa SS, Bangash M, Chaudhary A, Schulten HJ, Al-Qahtani M, Faheem M, Pushparaj PN, Mathew S, Kumosani TA, Kalamegam G, Al-Qahtani M, Al-Allaf FA, Abduljaleel Z, Alashwal A, Taher MM, Bouazzaoui A, Abalkhail H, Ba-Hammam FA, Athar M, Kalamegam G, Pushparaj PN, Abu-Elmagd M, Ahmed F, Sait KH, Anfinan N, Gari M, Chaudhary A, Abuzenadah A, Assidi M, Al-Qahtani M, Mami NB, Haffani YZ, Medhioub M, Hamzaoui L, Cherif A, Azouz M, Kalamegam G, Khan F, Mathew S, Nasser MI, Rasool M, Ahmed F, Pushparaj PN, Al-Qahtani M, Turkistany SA, Al-harbi LM, Dallol A, Sabir J, Chaudhary A, Abuzenadah A, Al-Madoudi B, Al-Aslani B, Al-Harbi K, Al-Jahdali R, Qudaih H, Al Hamzy E, Assidi M, Al Qahtani M, Ilyas AM, Ahmed Y, Gari M, Ahmed F, Alqahtani M, Salem N, Karim S, Alhathli EM, Abusamra H, Eldin HFN, Al-Qahtani MH, Kumar S, Al-Adwani F, Hussein D, Al-Sharif M, Jamal A, Al-Ghamdi F, Al-Maghrabi J, Baeesa SS, Bangash M, Chaudhary A, Al-Qahtani M, Schulten HJ, Alamandi A, Alotibi R, Hussein D, Karim S, Al-Maghrabi J, Al-Ghamdi F, Jamal A, Baeesa SS, Bangash M, Chaudhary A, Schulten HJ, Al-Qahtani M, Subhi O, Bagatian N, Karim S, Al-Johari A, Al-Hamour OA, Al-Aradati H, Al-Mutawa A, Al-Mashat F, Al-Maghrabi J, Schulten HJ, Al-Qahtani M, Bagatian N, Subhi O, Karim S, Al-Johari A, Al-Hamour OA, Al-Mutawa A, Al-Aradati H, Al-Mashat F, Al-Qahtani M, Schulten HJ, Al-Maghrabi J, shah MW, Yasir M, Azhar EI, Al-Masoodi S, Haffani YZ, Azouz M, Khamla E, Jlassi C, Masmoudi AS, Cherif A, Belbahri L, Al-Khayyat S, Attas R, Abu-Sanad A, Abuzinadah M, Merdad A, Dallol A, Chaudhary A, Al-Qahtani M, Abuzenadah A, Bouazzi H, Trujillo C, Alwasiyah MK, Al-Qahtani M, Alotaibi M, Nassir R, Sheikh IA, Kamal MA, Jiffri EH, Ashraf GM, Beg MA, Aziz MA, Ali R, Rasool M, Jamal MS, Samman N, Abdussami G, Periyasamy S, Warsi MK, Aldress M, Al Otaibi M, Al Yousef Z, Boudjelal M, Buhmeida A, Al-Qahtani MH, AlAbdulkarim I, Ghazala R, Mathew S, Hamed MH, Assidi M, Al-Qahtani M, Qadri I, Sheikh IA, Abu-Elmagd M, Turki RF, Damanhouri GA, Beg MA, Suhail M, Qureshi A, Jamal A, Pushparaj PN, Al-Qahtani M, Qadri I, El-Readi MZ, Eid SY, Wink M, Isa AM, Alnuaim L, Almutawa J, Abu-Rafae B, Alasiri S, Binsaleh S, Nazam N, Lone MI, Ahmad W, Ansari SA, Alqahtani MH. Shay JW, et al. BMC Genomics. 2016 Jul 20;17 Suppl 6(Suppl 6):487. doi: 10.1186/s12864-016-2858-0. BMC Genomics. 2016. PMID: 27454254 Free PMC article.
Al-Qahtani P63 Simultaneous genetic screening of the coagulation pathway genes using the Thromboscan targeted sequencing panel Hani A. ...Al-Qahtani, Saif Ahmad P97 Identification of drug lead molecule against vp35 protein of Ebola virus: An In-Silico approach Iftik …
Al-Qahtani P63 Simultaneous genetic screening of the coagulation pathway genes using the Thromboscan targeted sequencing panel Hani A …
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
Woyach JA, Furman RR, Liu TM, Ozer HG, Zapatka M, Ruppert AS, Xue L, Li DH, Steggerda SM, Versele M, Dave SS, Zhang J, Yilmaz AS, Jaglowski SM, Blum KA, Lozanski A, Lozanski G, James DF, Barrientos JC, Lichter P, Stilgenbauer S, Buggy JJ, Chang BY, Johnson AJ, Byrd JC. Woyach JA, et al. N Engl J Med. 2014 Jun 12;370(24):2286-94. doi: 10.1056/NEJMoa1400029. Epub 2014 May 28. N Engl J Med. 2014. PMID: 24869598 Free PMC article.
We evaluated patients with relapsed disease to identify mutations that may mediate ibrutinib resistance. METHODS: We performed whole-exome sequencing at baseline and the time of relapse on samples from six patients with acquired resistance
We evaluated patients with relapsed disease to identify mutations that may mediate ibrutinib resistance. METHODS: We performed …
Comparative transcriptome analyses of magainin I-susceptible and -resistant Escherichia coli strains.
Cardoso MH, de Almeida KC, Cândido ES, Fernandes GDR, Dias SC, de Alencar SA, Franco OL. Cardoso MH, et al. Microbiology. 2018 Nov;164(11):1383-1393. doi: 10.1099/mic.0.000725. Epub 2018 Oct 2. Microbiology. 2018. PMID: 30277857
Antimicrobial peptides (AMPs) have attracted considerable attention because of their multiple and complex mechanisms of action toward resistant bacteria. ...Here, the molecular mechanisms involved in Escherichia coli resistance to magainin I wer …
Antimicrobial peptides (AMPs) have attracted considerable attention because of their multiple and complex mechanisms of action
Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.
Winglee K, Lun S, Pieroni M, Kozikowski A, Bishai W. Winglee K, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):6873-81. doi: 10.1128/AAC.01341-15. Epub 2015 Aug 24. Antimicrob Agents Chemother. 2015. PMID: 26303802 Free PMC article.
In this study, we evaluated mechanisms of resistance to MP-III-71. We derived three independent M. tuberculosis mutants resistant to MP-III-71 and conducted whole-genome sequencing of these mutants. ...We also used transcriptome sequen
In this study, we evaluated mechanisms of resistance to MP-III-71. We derived three independent M. tuberculosis mutants res
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.
Rajan P, Stockley J, Sudbery IM, Fleming JT, Hedley A, Kalna G, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID, Leung HY. Rajan P, et al. BMC Cancer. 2014 Dec 18;14:977. doi: 10.1186/1471-2407-14-977. BMC Cancer. 2014. PMID: 25519703 Free PMC article.
BACKGROUND: Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential prognostic biomar …
BACKGROUND: Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour mo …
PA3225 Is a Transcriptional Repressor of Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa.
Hall CW, Zhang L, Mah TF. Hall CW, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e02114-16. doi: 10.1128/AAC.02114-16. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28584154 Free PMC article.
Intriguingly, further investigations revealed that the ΔPA3225 mutant was less susceptible to multiple, structurally unrelated antibiotics with various mechanisms of action when grown planktonically. ...By using transcriptome sequencing (RNA-seq), othe …
Intriguingly, further investigations revealed that the ΔPA3225 mutant was less susceptible to multiple, structurally unrelated antibiotics w …
Analysis of potential strategies for cadmium stress tolerance revealed by transcriptome analysis of upland cotton.
Chen H, Li Y, Ma X, Guo L, He Y, Ren Z, Kuang Z, Zhang X, Zhang Z. Chen H, et al. Sci Rep. 2019 Jan 14;9(1):86. doi: 10.1038/s41598-018-36228-z. Sci Rep. 2019. PMID: 30643161 Free PMC article.
We conducted transcriptome sequencing of the roots of cotton grown under three different cadmium concentrations, and analysed the potential strategies for coping with cadmium stress. ...There are three main mechanisms by which cotton responds to cadmium stres …
We conducted transcriptome sequencing of the roots of cotton grown under three different cadmium concentrations, and analysed …
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