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The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment.
Haendel MA, Chute CG, Bennett TD, Eichmann DA, Guinney J, Kibbe WA, Payne PRO, Pfaff ER, Robinson PN, Saltz JH, Spratt H, Suver C, Wilbanks J, Wilcox AB, Williams AE, Wu C, Blacketer C, Bradford RL, Cimino JJ, Clark M, Colmenares EW, Francis PA, Gabriel D, Graves A, Hemadri R, Hong SS, Hripscak G, Jiao D, Klann JG, Kostka K, Lee AM, Lehmann HP, Lingrey L, Miller RT, Morris M, Murphy SN, Natarajan K, Palchuk MB, Sheikh U, Solbrig H, Visweswaran S, Walden A, Walters KM, Weber GM, Zhang XT, Zhu RL, Amor B, Girvin AT, Manna A, Qureshi N, Kurilla MG, Michael SG, Portilla LM, Rutter JL, Austin CP, Gersing KR; N3C Consortium. Haendel MA, et al. J Am Med Inform Assoc. 2021 Mar 1;28(3):427-443. doi: 10.1093/jamia/ocaa196. J Am Med Inform Assoc. 2021. PMID: 32805036 Free PMC article.
OBJECTIVE: Coronavirus disease 2019 (COVID-19) poses societal challenges that require expeditious data and knowledge sharing. ...CONCLUSIONS: The N3C has demonstrated that a multisite collaborative learning health network can overcome barriers to rapidly buil …
OBJECTIVE: Coronavirus disease 2019 (COVID-19) poses societal challenges that require expeditious data and knowledge sharing. …
Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes.
Reese JT, Blau H, Casiraghi E, Bergquist T, Loomba JJ, Callahan TJ, Laraway B, Antonescu C, Coleman B, Gargano M, Wilkins KJ, Cappelletti L, Fontana T, Ammar N, Antony B, Murali TM, Caufield JH, Karlebach G, McMurry JA, Williams A, Moffitt R, Banerjee J, Solomonides AE, Davis H, Kostka K, Valentini G, Sahner D, Chute CG, Madlock-Brown C, Haendel MA, Robinson PN; N3C Consortium; RECOVER Consortium. Reese JT, et al. EBioMedicine. 2023 Jan;87:104413. doi: 10.1016/j.ebiom.2022.104413. Epub 2022 Dec 21. EBioMedicine. 2023. PMID: 36563487 Free PMC article.
BACKGROUND: Stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. ...Additionally, the generalisability of machine learning classification of COVID …
BACKGROUND: Stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) wo …
Diabetes medications and associations with Covid-19 outcomes in the N3C database: A national retrospective cohort study.
Bramante CT, Johnson SG, Garcia V, Evans MD, Harper J, Wilkins KJ, Huling JD, Mehta H, Alexander C, Tronieri J, Hong S, Kahkoska A, Alamgir J, Koraishy F, Hartman K, Yang K, Abrahamsen T, Stürmer T, Buse JB; N3C core authors. Bramante CT, et al. PLoS One. 2022 Nov 17;17(11):e0271574. doi: 10.1371/journal.pone.0271574. eCollection 2022. PLoS One. 2022. PMID: 36395143 Free PMC article.
This took place in the National COVID Cohort Collaborative (N3C) longitudinal U.S. cohort of adults with +SARS-CoV-2 result between January 1 2020 to June 1 2021. Findings included hospitalization or ventilation or mortality from COVID- …
This took place in the National COVID Cohort Collaborative (N3C) longitudinal U.S. cohort of adults with +SARS-CoV …
Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study.
Salah HM, Fudim M, O'Neil ST, Manna A, Chute CG, Caughey MC. Salah HM, et al. Nat Commun. 2022 Jul 15;13(1):4117. doi: 10.1038/s41467-022-31834-y. Nat Commun. 2022. PMID: 35840623 Free PMC article.
Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. ...In conclusion, …
Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 …
Generalizable Long COVID Subtypes: Findings from the NIH N3C and RECOVER Programs.
Reese JT, Blau H, Bergquist T, Loomba JJ, Callahan T, Laraway B, Antonescu C, Casiraghi E, Coleman B, Gargano M, Wilkins KJ, Cappelletti L, Fontana T, Ammar N, Antony B, Murali TM, Karlebach G, McMurry JA, Williams A, Moffitt R, Banerjee J, Solomonides AE, Davis H, Kostka K, Valentini G, Sahner D, Chute CG, Madlock-Brown C, Haendel MA, Robinson PN; RECOVER Consortium. Reese JT, et al. medRxiv [Preprint]. 2022 Jul 20:2022.05.24.22275398. doi: 10.1101/2022.05.24.22275398. medRxiv. 2022. Update in: EBioMedicine. 2023 Jan;87:104413. doi: 10.1016/j.ebiom.2022.104413 PMID: 35665012 Free PMC article. Updated. Preprint.
Accurate stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. ...There was a significant association of cluster membership with a range of pre-existing c …
Accurate stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would …
SARS-CoV-2 Infection is Associated with an Increase in New Diagnoses of Schizophrenia Spectrum and Psychotic Disorder: A Study Using the US National COVID Cohort Collaborative (N3C).
Rahman A, Russell M, Zheng W, Eckrich D, Ahmed I. Rahman A, et al. medRxiv [Preprint]. 2023 Dec 5:2023.12.05.23299473. doi: 10.1101/2023.12.05.23299473. medRxiv. 2023. Update in: PLoS One. 2024 May 30;19(5):e0295891. doi: 10.1371/journal.pone.0295891 PMID: 38106125 Free PMC article. Updated. Preprint.
Amid the ongoing global repercussions of SARS-CoV-2, it's crucial to comprehend its potential long-term psychiatric effects. Several recent studies have suggested a link between COVID-19 and subsequent mental health disorders. ...Intriguingly, o …
Amid the ongoing global repercussions of SARS-CoV-2, it's crucial to comprehend its potential long-term psychiatric eff …
Glycemic Control and Clinical Outcomes in U.S. Patients With COVID-19: Data From the National COVID Cohort Collaborative (N3C) Database.
Wong R, Hall M, Vaddavalli R, Anand A, Arora N, Bramante CT, Garcia V, Johnson S, Saltz M, Tronieri JS, Yoo YJ, Buse JB, Saltz J, Miller J, Moffitt R; N3C Consortium. Wong R, et al. Diabetes Care. 2022 Feb 24;45(5):1099-106. doi: 10.2337/dc21-2186. Online ahead of print. Diabetes Care. 2022. PMID: 35202458 Free PMC article.
OBJECTIVE: The purpose of the study is to evaluate the relationship between HbA1c and severity of coronavirus disease 2019 (COVID-19) outcomes in patients with type 2 diabetes (T2D) with acute COVID-19 infection. RESEARCH DESIGN AND METHODS: We conduct …
OBJECTIVE: The purpose of the study is to evaluate the relationship between HbA1c and severity of coronavirus disease 2019 (COVID- …
The Association of the Levels of High-Density Lipoprotein and Apolipoprotein A1 with SARS-CoV-2 Infection and COVID-19 Severity: An Analysis of the N3C Database.
Li MH, Kulkarni R, Koizumi N, Andalibi A, On Behalf Of The N C Consortium. Li MH, et al. Biology (Basel). 2023 Jun 14;12(6):852. doi: 10.3390/biology12060852. Biology (Basel). 2023. PMID: 37372137 Free PMC article.
This study analyzed data from the National COVID Cohort Collaborative (N3C) database to investigate whether high-density lipoprotein (HDL) and its major protein component, apolipoprotein A1 (apoA1), are associated with severe COVID-19 sequelae, specifi …
This study analyzed data from the National COVID Cohort Collaborative (N3C) database to investigate whether high-density lipop …
Association Between COVID-19 and Mortality in Hip Fracture Surgery in the National COVID Cohort Collaborative (N3C): A Retrospective Cohort Study.
Levitt EB, Patch DA, Mabry S, Terrero A, Jaeger B, Haendel MA, Chute CG, Quade JH, Ponce B, Theiss S, Spitler CA, Johnson JP. Levitt EB, et al. J Am Acad Orthop Surg Glob Res Rev. 2022 Jan 4;6(1):e21.00282. doi: 10.5435/JAAOSGlobal-D-21-00282. J Am Acad Orthop Surg Glob Res Rev. 2022. PMID: 34982060 Free PMC article.
RESULTS: In this national study that included 3303 adults with hip fracture surgery, the 30-day mortality was 14.6% with COVID-19-positive versus 3.8% in COVID-19-negative, a notable difference. The all-cause mortality for hip fracture surgery was 27.0 …
RESULTS: In this national study that included 3303 adults with hip fracture surgery, the 30-day mortality was 14.6% with COVID-19 …
Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data.
Yang X, Sun J, Patel RC, Zhang J, Guo S, Zheng Q, Olex AL, Olatosi B, Weissman SB, Islam JY, Chute CG, Haendel M, Kirk GD, Li X; National COVID Cohort Collaborative Consortium. Yang X, et al. Lancet HIV. 2021 Nov;8(11):e690-e700. doi: 10.1016/S2352-3018(21)00239-3. Epub 2021 Oct 13. Lancet HIV. 2021. PMID: 34655550 Free PMC article.
BACKGROUND: Evidence of whether people living with HIV are at elevated risk of adverse COVID-19 outcomes is inconclusive. We aimed to investigate this association using the population-based National COVID Cohort Collaborative (N3C) data in the USA. MET …
BACKGROUND: Evidence of whether people living with HIV are at elevated risk of adverse COVID-19 outcomes is inconclusive. We a …
180 results