P30 NS055077/NS/NINDS NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2008	4
2009	7
2010	10
2011	26
2012	44
2013	41
2014	26
2015	40
2016	33
2017	43
2018	38
2019	21
2020	37
2021	40
2022	17
2023	1
2024	4
2025	1

1

FSH blockade improves cognition in mice with Alzheimer's disease.

Xiong J, Kang SS, Wang Z, Liu X, Kuo TC, Korkmaz F, Padilla A, Miyashita S, Chan P, Zhang Z, Katsel P, Burgess J, Gumerova A, Ievleva K, Sant D, Yu SP, Muradova V, Frolinger T, Lizneva D, Iqbal J, Goosens KA, Gera S, Rosen CJ, Haroutunian V, Ryu V, Yuen T, Zaidi M, Ye K. Xiong J, et al. Nature. 2022 Mar;603(7901):470-476. doi: 10.1038/s41586-022-04463-0. Epub 2022 Mar 2. Nature. 2022. PMID: 35236988 Free PMC article.

2

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis.

Wingo AP, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Robins C, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo TS. Wingo AP, et al. Nat Genet. 2021 Feb;53(2):143-146. doi: 10.1038/s41588-020-00773-z. Epub 2021 Jan 28. Nat Genet. 2021. PMID: 33510477 Free PMC article.

3

Evidence for brain glucose dysregulation in Alzheimer's disease.

An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M. An Y, et al. Alzheimers Dement. 2018 Mar;14(3):318-329. doi: 10.1016/j.jalz.2017.09.011. Epub 2017 Oct 19. Alzheimers Dement. 2018. PMID: 29055815 Free PMC article.

4

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.

Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, Cairns NJ, Boylan KB, Dickson DW, Rademakers R, Zhang YJ, Petrucelli L, Sattler R, Zarnescu DC, Glass JD, Rossoll W. Chou CC, et al. Nat Neurosci. 2018 Feb;21(2):228-239. doi: 10.1038/s41593-017-0047-3. Epub 2018 Jan 8. Nat Neurosci. 2018. PMID: 29311743 Free PMC article.

5

Brain proteome-wide association study implicates novel proteins in depression pathogenesis.

Wingo TS, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Lori A, Kim PJ, Ressler KJ, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo AP. Wingo TS, et al. Nat Neurosci. 2021 Jun;24(6):810-817. doi: 10.1038/s41593-021-00832-6. Epub 2021 Apr 12. Nat Neurosci. 2021. PMID: 33846625 Free PMC article.

6

FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice.

Xiong J, Kang SS, Wang M, Wang Z, Xia Y, Liao J, Liu X, Yu SP, Zhang Z, Ryu V, Yuen T, Zaidi M, Ye K. Xiong J, et al. Nat Commun. 2023 Oct 18;14(1):6577. doi: 10.1038/s41467-023-42282-7. Nat Commun. 2023. PMID: 37852961 Free PMC article.

7

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease.

Higginbotham L, Ping L, Dammer EB, Duong DM, Zhou M, Gearing M, Hurst C, Glass JD, Factor SA, Johnson ECB, Hajjar I, Lah JJ, Levey AI, Seyfried NT. Higginbotham L, et al. Sci Adv. 2020 Oct 21;6(43):eaaz9360. doi: 10.1126/sciadv.aaz9360. Print 2020 Oct. Sci Adv. 2020. PMID: 33087358 Free PMC article.

8

Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease.

Chen C, Zhou Y, Wang H, Alam A, Kang SS, Ahn EH, Liu X, Jia J, Ye K. Chen C, et al. EMBO J. 2021 Sep 1;40(17):e106320. doi: 10.15252/embj.2020106320. Epub 2021 Jul 14. EMBO J. 2021. PMID: 34260075 Free PMC article.

9

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Rangaraju S, et al. Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8. Mol Neurodegener. 2018. PMID: 29784049 Free PMC article.

10

Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer's Disease.

Kelberman MA, Anderson CR, Chlan E, Rorabaugh JM, McCann KE, Weinshenker D. Kelberman MA, et al. J Alzheimers Dis. 2022;86(3):1037-1059. doi: 10.3233/JAD-215546. J Alzheimers Dis. 2022. PMID: 35147547 Free PMC article.

11

Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression.

Xia Y, Qadota H, Wang ZH, Liu P, Liu X, Ye KX, Matheny CJ, Berglund K, Yu SP, Drake D, Bennett DA, Wang XC, Yankner BA, Benian GM, Ye K. Xia Y, et al. Sci Adv. 2022 Apr;8(13):eabj8658. doi: 10.1126/sciadv.abj8658. Epub 2022 Mar 30. Sci Adv. 2022. PMID: 35353567 Free PMC article.

12

The Exceptional Vulnerability of Humans to Alzheimer's Disease.

Walker LC, Jucker M. Walker LC, et al. Trends Mol Med. 2017 Jun;23(6):534-545. doi: 10.1016/j.molmed.2017.04.001. Epub 2017 May 5. Trends Mol Med. 2017. PMID: 28483344 Free PMC article. Review.

13

Quantitative proteomics to decipher ubiquitin signaling.

Chen PC, Na CH, Peng J. Chen PC, et al. Amino Acids. 2012 Sep;43(3):1049-60. doi: 10.1007/s00726-012-1286-y. Epub 2012 Jul 22. Amino Acids. 2012. PMID: 22821265 Free PMC article. Review.

14

Human brain glycoform coregulation network and glycan modification alterations in Alzheimer's disease.

Zhang Q, Ma C, Chin LS, Pan S, Li L. Zhang Q, et al. Sci Adv. 2024 Apr 5;10(14):eadk6911. doi: 10.1126/sciadv.adk6911. Epub 2024 Apr 5. Sci Adv. 2024. PMID: 38579000 Free PMC article.

15

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease.

Yang R, Gao G, Mao Z, Yang Q. Yang R, et al. Parkinsons Dis. 2016;2016:2613401. doi: 10.1155/2016/2613401. Epub 2016 Jun 16. Parkinsons Dis. 2016. PMID: 27413575 Free PMC article. Review.

16

Social experience in adolescence shapes prefrontal cortex structure and function in adulthood.

Li DC, Hinton EA, Guo J, Knight KA, Sequeira MK, Wynne ME, Dighe NM, Gourley SL. Li DC, et al. Mol Psychiatry. 2024 Sep;29(9):2787-2798. doi: 10.1038/s41380-024-02540-6. Epub 2024 Apr 5. Mol Psychiatry. 2024. PMID: 38580810

17

Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.

Rotterman TM, Haley-Johnson Z, Pottorf TS, Chopra T, Chang E, Zhang S, McCallum WM, Fisher S, Franklin H, Alvarez M, Cope TC, Alvarez FJ. Rotterman TM, et al. Cell Rep. 2024 Feb 27;43(2):113776. doi: 10.1016/j.celrep.2024.113776. Epub 2024 Feb 15. Cell Rep. 2024. PMID: 38367237 Free PMC article.

18

MicroRNA regulation of persistent stress-enhanced memory.

Daws SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA. Daws SE, et al. Mol Psychiatry. 2020 May;25(5):965-976. doi: 10.1038/s41380-019-0432-2. Epub 2019 May 29. Mol Psychiatry. 2020. PMID: 31142820 Free PMC article.

19

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.

Huang M, Modeste E, Dammer E, Merino P, Taylor G, Duong DM, Deng Q, Holler CJ, Gearing M, Dickson D, Seyfried NT, Kukar T. Huang M, et al. Acta Neuropathol Commun. 2020 Oct 7;8(1):163. doi: 10.1186/s40478-020-01037-x. Acta Neuropathol Commun. 2020. PMID: 33028409 Free PMC article.

20

Compositional complexity of rods and rings.

Schiavon CR, Griffin ME, Pirozzi M, Parashuraman R, Zhou W, Jinnah HA, Reines D, Kahn RA. Schiavon CR, et al. Mol Biol Cell. 2018 Sep 15;29(19):2303-2316. doi: 10.1091/mbc.E18-05-0274. Epub 2018 Jul 19. Mol Biol Cell. 2018. PMID: 30024290 Free PMC article.

21

Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau.

Rayaprolu S, Higginbotham L, Bagchi P, Watson CM, Zhang T, Levey AI, Rangaraju S, Seyfried NT. Rayaprolu S, et al. Neuropsychopharmacology. 2021 Jan;46(1):98-115. doi: 10.1038/s41386-020-00840-3. Epub 2020 Sep 8. Neuropsychopharmacology. 2021. PMID: 32898852 Free PMC article. Review.

22

A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.

Rojas A, Ganesh T, Wang W, Wang J, Dingledine R. Rojas A, et al. Neurobiol Dis. 2020 Jan;133:104399. doi: 10.1016/j.nbd.2019.02.010. Epub 2019 Feb 25. Neurobiol Dis. 2020. PMID: 30818067 Free PMC article. Review.

23

Roles for ELMOD2 and Rootletin in ciliogenesis.

Turn RE, Linnert J, Gigante ED, Wolfrum U, Caspary T, Kahn RA. Turn RE, et al. Mol Biol Cell. 2021 Apr 15;32(8):800-822. doi: 10.1091/mbc.E20-10-0635. Epub 2021 Feb 17. Mol Biol Cell. 2021. PMID: 33596093 Free PMC article.

24

The Malignant Protein Puzzle.

Walker LC, Jucker M. Walker LC, et al. Cerebrum. 2016 Mar 1;2016:cer-04-16. eCollection 2016 Mar-Apr. Cerebrum. 2016. PMID: 27408676 Free PMC article.

25

Structural analysis of the full-length human LRRK2.

Myasnikov A, Zhu H, Hixson P, Xie B, Yu K, Pitre A, Peng J, Sun J. Myasnikov A, et al. Cell. 2021 Jun 24;184(13):3519-3527.e10. doi: 10.1016/j.cell.2021.05.004. Epub 2021 Jun 8. Cell. 2021. PMID: 34107286 Free PMC article.

26

Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.

Mullin AP, Gokhale A, Larimore J, Faundez V. Mullin AP, et al. Mol Neurobiol. 2011 Aug;44(1):53-64. doi: 10.1007/s12035-011-8183-3. Epub 2011 Apr 26. Mol Neurobiol. 2011. PMID: 21520000 Free PMC article. Review.

27

Neuropathology of cervical dystonia.

Prudente CN, Pardo CA, Xiao J, Hanfelt J, Hess EJ, Ledoux MS, Jinnah HA. Prudente CN, et al. Exp Neurol. 2013 Mar;241:95-104. doi: 10.1016/j.expneurol.2012.11.019. Epub 2012 Nov 27. Exp Neurol. 2013. PMID: 23195594 Free PMC article.

28

Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases.

Walker LC. Walker LC. Annu Rev Genet. 2016 Nov 23;50:329-346. doi: 10.1146/annurev-genet-120215-034943. Annu Rev Genet. 2016. PMID: 27893962 Free PMC article. Review.

29

Shared mechanisms across the major psychiatric and neurodegenerative diseases.

Wingo TS, Liu Y, Gerasimov ES, Vattathil SM, Wynne ME, Liu J, Lori A, Faundez V, Bennett DA, Seyfried NT, Levey AI, Wingo AP. Wingo TS, et al. Nat Commun. 2022 Jul 26;13(1):4314. doi: 10.1038/s41467-022-31873-5. Nat Commun. 2022. PMID: 35882878 Free PMC article.

30

LSD1 protects against hippocampal and cortical neurodegeneration.

Christopher MA, Myrick DA, Barwick BG, Engstrom AK, Porter-Stransky KA, Boss JM, Weinshenker D, Levey AI, Katz DJ. Christopher MA, et al. Nat Commun. 2017 Oct 9;8(1):805. doi: 10.1038/s41467-017-00922-9. Nat Commun. 2017. PMID: 28993646 Free PMC article.

31

Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.

Bassell GJ, Warren ST. Bassell GJ, et al. Neuron. 2008 Oct 23;60(2):201-14. doi: 10.1016/j.neuron.2008.10.004. Neuron. 2008. PMID: 18957214 Free PMC article. Review.

32

A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory.

Li DC, Dighe NM, Barbee BR, Pitts EG, Kochoian B, Blumenthal SA, Figueroa J, Leong T, Gourley SL. Li DC, et al. Nat Neurosci. 2022 Sep;25(9):1213-1224. doi: 10.1038/s41593-022-01148-9. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042313 Free PMC article.

33

C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease.

Liao J, Chen G, Liu X, Wei ZZ, Yu SP, Chen Q, Ye K. Liao J, et al. Mol Psychiatry. 2022 Jul;27(7):3034-3046. doi: 10.1038/s41380-022-01556-0. Epub 2022 Apr 14. Mol Psychiatry. 2022. PMID: 35422468 Free PMC article.

34

Early-life cocaine interferes with BDNF-mediated behavioral plasticity.

Hinton EA, Wheeler MG, Gourley SL. Hinton EA, et al. Learn Mem. 2014 Apr 15;21(5):253-7. doi: 10.1101/lm.033290.113. Learn Mem. 2014. PMID: 24737916 Free PMC article.

35

GABA and NMDA receptors in CRF neurons have opposing effects in fear acquisition and anxiety in central amygdala vs. bed nucleus of the stria terminalis.

Gafford GM, Ressler KJ. Gafford GM, et al. Horm Behav. 2015 Nov;76:136-42. doi: 10.1016/j.yhbeh.2015.04.001. Epub 2015 Apr 14. Horm Behav. 2015. PMID: 25888455 Free PMC article. Review.

36

Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites.

Ifrim MF, Janusz-Kaminska A, Bassell GJ. Ifrim MF, et al. Cell Rep. 2022 Nov 15;41(7):111658. doi: 10.1016/j.celrep.2022.111658. Cell Rep. 2022. PMID: 36384114 Free PMC article.

37

Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation.

Kang SS, Meng L, Zhang X, Wu Z, Mancieri A, Xie B, Liu X, Weinshenker D, Peng J, Zhang Z, Ye K. Kang SS, et al. Nat Struct Mol Biol. 2022 Apr;29(4):292-305. doi: 10.1038/s41594-022-00745-3. Epub 2022 Mar 24. Nat Struct Mol Biol. 2022. PMID: 35332321 Free PMC article.

38

Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A.

Zhong W, Wu A, Berglund K, Gu X, Jiang MQ, Talati J, Zhao J, Wei L, Yu SP. Zhong W, et al. Alzheimers Dement. 2022 Feb;18(2):222-239. doi: 10.1002/alz.12398. Epub 2021 Jun 20. Alzheimers Dement. 2022. PMID: 34151525 Free PMC article.

39

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.

Owings JP, Kuiper EG, Prezioso SM, Meisner J, Varga JJ, Zelinskaya N, Dammer EB, Duong DM, Seyfried NT, Albertí S, Conn GL, Goldberg JB. Owings JP, et al. J Biol Chem. 2016 Feb 12;291(7):3280-90. doi: 10.1074/jbc.M115.706853. Epub 2015 Dec 16. J Biol Chem. 2016. PMID: 26677219 Free PMC article.

40

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions.

Schlingmann B, Overgaard CE, Molina SA, Lynn KS, Mitchell LA, Dorsainvil White S, Mattheyses AL, Guidot DM, Capaldo CT, Koval M. Schlingmann B, et al. Nat Commun. 2016 Jul 25;7:12276. doi: 10.1038/ncomms12276. Nat Commun. 2016. PMID: 27452368 Free PMC article.

41

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia.

Swarup V, Chang TS, Duong DM, Dammer EB, Dai J, Lah JJ, Johnson ECB, Seyfried NT, Levey AI, Geschwind DH. Swarup V, et al. Cell Rep. 2020 Jun 23;31(12):107807. doi: 10.1016/j.celrep.2020.107807. Cell Rep. 2020. PMID: 32579933 Free PMC article.

42

Optogenetically enhanced axon regeneration: motor versus sensory neuron-specific stimulation.

Ward PJ, Clanton SL 2nd, English AW. Ward PJ, et al. Eur J Neurosci. 2018 Feb;47(4):294-304. doi: 10.1111/ejn.13836. Epub 2018 Feb 10. Eur J Neurosci. 2018. PMID: 29363200

43

Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase.

Kang SS, Wu Z, Liu X, Edgington-Mitchell L, Ye K. Kang SS, et al. Neurotherapeutics. 2022 Jul;19(4):1283-1297. doi: 10.1007/s13311-022-01248-1. Epub 2022 May 20. Neurotherapeutics. 2022. PMID: 35595958 Free PMC article.

44

Genetic Evidence Supporting a Causal Role of Depression in Alzheimer's Disease.

Harerimana NV, Liu Y, Gerasimov ES, Duong D, Beach TG, Reiman EM, Schneider JA, Boyle P, Lori A, Bennett DA, Lah JJ, Levey AI, Seyfried NT, Wingo TS, Wingo AP. Harerimana NV, et al. Biol Psychiatry. 2022 Jul 1;92(1):25-33. doi: 10.1016/j.biopsych.2021.11.025. Epub 2021 Dec 16. Biol Psychiatry. 2022. PMID: 35177243 Free PMC article.

45

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease.

Chen G, Ahn EH, Kang SS, Xia Y, Liu X, Zhang Z, Ye K. Chen G, et al. Adv Sci (Weinh). 2022 Mar;9(7):e2103396. doi: 10.1002/advs.202103396. Epub 2022 Jan 12. Adv Sci (Weinh). 2022. PMID: 35023303 Free PMC article.

46

Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.

Wu Z, Chen C, Kang SS, Liu X, Gu X, Yu SP, Keene CD, Cheng L, Ye K. Wu Z, et al. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2100986118. doi: 10.1073/pnas.2100986118. Proc Natl Acad Sci U S A. 2021. PMID: 34140411 Free PMC article.

47

Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease.

Liao J, Chen C, Ahn EH, Liu X, Li H, Edgington-Mitchell LE, Lu Z, Ming S, Ye K. Liao J, et al. Neuropharmacology. 2021 Oct 1;197:108737. doi: 10.1016/j.neuropharm.2021.108737. Epub 2021 Jul 31. Neuropharmacology. 2021. PMID: 34343610 Free PMC article.

48

A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies.

Yao Y, Kang SS, Xia Y, Wang ZH, Liu X, Muller T, Sun YE, Ye K. Yao Y, et al. Brain. 2021 Jul 28;144(6):1833-1852. doi: 10.1093/brain/awab062. Brain. 2021. PMID: 33880508 Free PMC article.

49

Beta-catenin is required for memory consolidation.

Maguschak KA, Ressler KJ. Maguschak KA, et al. Nat Neurosci. 2008 Nov;11(11):1319-26. doi: 10.1038/nn.2198. Epub 2008 Sep 28. Nat Neurosci. 2008. PMID: 18820693 Free PMC article.

50

Brain microRNAs are associated with variation in cognitive trajectory in advanced age.

Wingo AP, Wang M, Liu J, Breen MS, Yang HS, Tang B, Schneider JA, Seyfried NT, Lah JJ, Levey AI, Bennett DA, Jin P, De Jager PL, Wingo TS. Wingo AP, et al. Transl Psychiatry. 2022 Feb 1;12(1):47. doi: 10.1038/s41398-022-01806-3. Transl Psychiatry. 2022. PMID: 35105862 Free PMC article.

51

Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells.

Kudelka MR, Antonopoulos A, Wang Y, Duong DM, Song X, Seyfried NT, Dell A, Haslam SM, Cummings RD, Ju T. Kudelka MR, et al. Nat Methods. 2016 Jan;13(1):81-6. doi: 10.1038/nmeth.3675. Epub 2015 Nov 30. Nat Methods. 2016. PMID: 26619014 Free PMC article.

52

Bidirectional coordination of actions and habits by TrkB in mice.

Pitts EG, Li DC, Gourley SL. Pitts EG, et al. Sci Rep. 2018 Mar 14;8(1):4495. doi: 10.1038/s41598-018-22560-x. Sci Rep. 2018. PMID: 29540698 Free PMC article.

53

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Pottier C, Zhou X, Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff … See abstract for full author list ➔ Pottier C, et al. Lancet Neurol. 2018 Jun;17(6):548-558. doi: 10.1016/S1474-4422(18)30126-1. Epub 2018 Apr 30. Lancet Neurol. 2018. PMID: 29724592 Free PMC article.

54

Asparaginyl endopeptidase cleaves TDP-43 in brain.

Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT. Herskowitz JH, et al. Proteomics. 2012 Aug;12(15-16):2455-63. doi: 10.1002/pmic.201200006. Proteomics. 2012. PMID: 22718532 Free PMC article.

55

Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.

Niu Y, Guo X, Chen Y, Wang CE, Gao J, Yang W, Kang Y, Si W, Wang H, Yang SH, Li S, Ji W, Li XJ. Niu Y, et al. Hum Mol Genet. 2015 Apr 15;24(8):2308-17. doi: 10.1093/hmg/ddu748. Epub 2014 Dec 30. Hum Mol Genet. 2015. PMID: 25552648 Free PMC article.

56

Identification of a lipid scrambling domain in ANO6/TMEM16F.

Yu K, Whitlock JM, Lee K, Ortlund EA, Cui YY, Hartzell HC. Yu K, et al. Elife. 2015 Jun 9;4:e06901. doi: 10.7554/eLife.06901. Elife. 2015. PMID: 26057829 Free PMC article.

57

The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.

Engstrom AK, Walker AC, Moudgal RA, Myrick DA, Kyle SM, Bai Y, Rowley MJ, Katz DJ. Engstrom AK, et al. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29133-29143. doi: 10.1073/pnas.2013552117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139560 Free PMC article.

58

Adolescent-onset GABAA α1 silencing regulates reward-related decision making.

Butkovich LM, DePoy LM, Allen AG, Shapiro LP, Swanson AM, Gourley SL. Butkovich LM, et al. Eur J Neurosci. 2015 Aug;42(4):2114-2121. doi: 10.1111/ejn.12995. Epub 2015 Aug 4. Eur J Neurosci. 2015. PMID: 26096050 Free PMC article.

59

Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice.

Huang S, Yang S, Guo J, Yan S, Gaertig MA, Li S, Li XJ. Huang S, et al. Cell Rep. 2015 Oct 6;13(1):196-208. doi: 10.1016/j.celrep.2015.08.060. Epub 2015 Sep 17. Cell Rep. 2015. PMID: 26387956 Free PMC article.

60

Fruit flies medicate offspring after seeing parasites.

Kacsoh BZ, Lynch ZR, Mortimer NT, Schlenke TA. Kacsoh BZ, et al. Science. 2013 Feb 22;339(6122):947-50. doi: 10.1126/science.1229625. Science. 2013. PMID: 23430653 Free PMC article.

61

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.

Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z, Ye K. Chen G, et al. Sci Adv. 2021 Apr 16;7(16):eabe4499. doi: 10.1126/sciadv.abe4499. Print 2021 Apr. Sci Adv. 2021. PMID: 33863723 Free PMC article.

62

Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs.

Tora MS, Texakalidis P, Neill S, Wetzel J, Rindler RS, Hardcastle N, Nagarajan PP, Krasnopeyev A, Roach C, James R, Bruce JN, Canoll P, Federici T, Oshinski JN, Boulis NM. Tora MS, et al. Sci Rep. 2020 Mar 24;10(1):5291. doi: 10.1038/s41598-020-62167-9. Sci Rep. 2020. PMID: 32210315 Free PMC article.

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ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.

Wang ZH, Xia Y, Liu P, Liu X, Edgington-Mitchell L, Lei K, Yu SP, Wang XC, Ye K. Wang ZH, et al. Prog Neurobiol. 2021 Jul;202:102032. doi: 10.1016/j.pneurobio.2021.102032. Epub 2021 Mar 11. Prog Neurobiol. 2021. PMID: 33716161 Free PMC article.

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Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.

Kim SH, Farrell K, Cosentino S, Vonsattel JG, Faust PL, Cortes EP, Bennet DA, Louis ED, Crary JF. Kim SH, et al. J Neuropathol Exp Neurol. 2021 Sep 27;80(9):835-843. doi: 10.1093/jnen/nlab073. J Neuropathol Exp Neurol. 2021. PMID: 34363663 Free PMC article.

65

BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.

Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG. Zhu D, et al. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. doi: 10.1016/j.ccell.2018.05.006. Cancer Cell. 2018. PMID: 29894688 Free PMC article.

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Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.

Xia Y, Wang ZH, Zhang Z, Liu X, Yu SP, Wang JZ, Wang XC, Ye K. Xia Y, et al. Prog Neurobiol. 2021 Sep;204:102113. doi: 10.1016/j.pneurobio.2021.102113. Epub 2021 Jun 21. Prog Neurobiol. 2021. PMID: 34166772 Free PMC article.

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Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease.

Hardy RA, Rached NA, Jones JA, Archer DR, Hyacinth HI. Hardy RA, et al. Exp Biol Med (Maywood). 2021 Jan;246(1):106-120. doi: 10.1177/1535370220958011. Epub 2020 Sep 22. Exp Biol Med (Maywood). 2021. PMID: 32962408 Free PMC article.

68

Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer's disease neuropathologies.

Beebe-Wang N, Celik S, Weinberger E, Sturmfels P, De Jager PL, Mostafavi S, Lee SI. Beebe-Wang N, et al. Nat Commun. 2021 Sep 10;12(1):5369. doi: 10.1038/s41467-021-25680-7. Nat Commun. 2021. PMID: 34508095 Free PMC article.

69

Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development.

Shiu FH, Wong JC, Yamamoto T, Lala T, Purcell RH, Owino S, Zhu D, Van Meir EG, Hall RA, Escayg A. Shiu FH, et al. Exp Neurol. 2022 May;351:113994. doi: 10.1016/j.expneurol.2022.113994. Epub 2022 Jan 31. Exp Neurol. 2022. PMID: 35114205 Free PMC article.

70

GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.

Owino S, Giddens MM, Jiang JG, Nguyen TT, Shiu FH, Lala T, Gearing M, McCrary MR, Gu X, Wei L, Yu SP, Hall RA. Owino S, et al. Exp Neurol. 2021 Aug;342:113719. doi: 10.1016/j.expneurol.2021.113719. Epub 2021 Apr 9. Exp Neurol. 2021. PMID: 33839144 Free PMC article.

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Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.

Srikanth P, Lagomarsino VN, Pearse RV 2nd, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Srikanth P, et al. Transl Psychiatry. 2018 Nov 8;8(1):245. doi: 10.1038/s41398-018-0281-9. Transl Psychiatry. 2018. PMID: 30410030 Free PMC article.

72

Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.

Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Yang W, et al. J Neurosci. 2015 May 27;35(21):8345-58. doi: 10.1523/JNEUROSCI.0772-15.2015. J Neurosci. 2015. PMID: 26019347 Free PMC article.

73

Wnt signaling in amygdala-dependent learning and memory.

Maguschak KA, Ressler KJ. Maguschak KA, et al. J Neurosci. 2011 Sep 14;31(37):13057-67. doi: 10.1523/JNEUROSCI.3248-11.2011. J Neurosci. 2011. PMID: 21917789 Free PMC article.

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Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability.

Qi Q, Li DY, Luo HR, Guan KL, Ye K. Qi Q, et al. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7255-60. doi: 10.1073/pnas.1505917112. Epub 2015 May 26. Proc Natl Acad Sci U S A. 2015. PMID: 26039999 Free PMC article.

75

Vesicular monoamine transporter 2 mediates fear behavior in mice.

Branco RC, Burkett JP, Black CA, Winokur E, Ellsworth W, Dhamsania RK, Lohr KM, Schroeder JP, Weinshenker D, Jovanovic T, Miller GW. Branco RC, et al. Genes Brain Behav. 2020 Jun;19(5):e12634. doi: 10.1111/gbb.12634. Epub 2020 Jan 14. Genes Brain Behav. 2020. PMID: 31898856 Free PMC article.

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The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism.

Corgiat EB, List SM, Rounds JC, Yu D, Chen P, Corbett AH, Moberg KH. Corgiat EB, et al. G3 (Bethesda). 2022 May 30;12(6):jkac100. doi: 10.1093/g3journal/jkac100. G3 (Bethesda). 2022. PMID: 35471546 Free PMC article.

77

Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease.

Yin P, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S. Yin P, et al. EMBO Rep. 2020 Jun 4;21(6):e49783. doi: 10.15252/embr.201949783. Epub 2020 Apr 9. EMBO Rep. 2020. PMID: 32270922 Free PMC article.

78

Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.

Beckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, Levey AI, Seyfried NT, Dammer EB, Duong D, Lah JJ, Haure-Mirande JV, Shackleton B, Fanutza T, Blitzer R, Kenny E, Zhu J, Haroutunian V, Katsel P, Gandy S, Tu Z, Ehrlich ME, Zhang B, Salton SR, Schadt EE. Beckmann ND, et al. Nat Commun. 2020 Aug 7;11(1):3942. doi: 10.1038/s41467-020-17405-z. Nat Commun. 2020. PMID: 32770063 Free PMC article.

79

Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice.

Ahn EH, Lei K, Kang SS, Wang ZH, Liu X, Hong W, Wang YT, Edgington-Mitchell LE, Jin L, Ye K. Ahn EH, et al. Mol Psychiatry. 2021 Dec;26(12):7838-7850. doi: 10.1038/s41380-021-01284-x. Epub 2021 Sep 6. Mol Psychiatry. 2021. PMID: 34489530

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Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid.

Henderson BW, Greathouse KM, Ramdas R, Walker CK, Rao TC, Bach SV, Curtis KA, Day JJ, Mattheyses AL, Herskowitz JH. Henderson BW, et al. Sci Signal. 2019 Jun 25;12(587):eaaw9318. doi: 10.1126/scisignal.aaw9318. Sci Signal. 2019. PMID: 31239325 Free PMC article.

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Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling.

Dias BG, Goodman JV, Ahluwalia R, Easton AE, Andero R, Ressler KJ. Dias BG, et al. Neuron. 2014 Aug 20;83(4):906-18. doi: 10.1016/j.neuron.2014.07.019. Epub 2014 Aug 7. Neuron. 2014. PMID: 25123309 Free PMC article.

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Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study.

Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, Dickson DW, McKee AC, Stein TD, Trojanowski JQ, Woltjer RL, Kovacs GG, Kofler JK, Kaye J, White CL 3rd, Crary JF. Iida MA, et al. Acta Neuropathol Commun. 2021 Aug 5;9(1):134. doi: 10.1186/s40478-021-01233-3. Acta Neuropathol Commun. 2021. PMID: 34353357 Free PMC article.

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ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.

Kang SS, Ahn EH, Liu X, Bryson M, Miller GW, Weinshenker D, Ye K. Kang SS, et al. Acta Neuropathol. 2021 Jul;142(1):139-158. doi: 10.1007/s00401-021-02315-1. Epub 2021 Apr 25. Acta Neuropathol. 2021. PMID: 33895869 Free PMC article.

84

TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies.

Xia Y, Wang ZH, Liu P, Edgington-Mitchell L, Liu X, Wang XC, Ye K. Xia Y, et al. Mol Psychiatry. 2021 Jul;26(7):2943-2963. doi: 10.1038/s41380-020-00863-8. Epub 2020 Aug 11. Mol Psychiatry. 2021. PMID: 32782380

85

Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase.

Chen C, Ahn EH, Liu X, Wang ZH, Luo S, Liao J, Ye K. Chen C, et al. ACS Chem Neurosci. 2021 Jul 7;12(13):2448-2461. doi: 10.1021/acschemneuro.1c00181. Epub 2021 Jun 9. ACS Chem Neurosci. 2021. PMID: 34106682 Free PMC article.

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Dendritic spines provide cognitive resilience against Alzheimer's disease.

Boros BD, Greathouse KM, Gentry EG, Curtis KA, Birchall EL, Gearing M, Herskowitz JH. Boros BD, et al. Ann Neurol. 2017 Oct;82(4):602-614. doi: 10.1002/ana.25049. Epub 2017 Oct 22. Ann Neurol. 2017. PMID: 28921611 Free PMC article.

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A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease.

Huang Y, Sun X, Jiang H, Yu S, Robins C, Armstrong MJ, Li R, Mei Z, Shi X, Gerasimov ES, De Jager PL, Bennett DA, Wingo AP, Jin P, Wingo TS, Qin ZS. Huang Y, et al. Nat Commun. 2021 Jul 22;12(1):4472. doi: 10.1038/s41467-021-24710-8. Nat Commun. 2021. PMID: 34294691 Free PMC article.

88

Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.

Gilbert-Ross M, Konen J, Koo J, Shupe J, Robinson BS, Wiles WG 4th, Huang C, Martin WD, Behera M, Smith GH, Hill CE, Rossi MR, Sica GL, Rupji M, Chen Z, Kowalski J, Kasinski AL, Ramalingam SS, Fu H, Khuri FR, Zhou W, Marcus AI. Gilbert-Ross M, et al. JCI Insight. 2017 Mar 9;2(5):e90487. doi: 10.1172/jci.insight.90487. JCI Insight. 2017. PMID: 28289710 Free PMC article.

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5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.

Bernstein AI, Lin Y, Street RC, Lin L, Dai Q, Yu L, Bao H, Gearing M, Lah JJ, Nelson PT, He C, Levey AI, Mullé JG, Duan R, Jin P. Bernstein AI, et al. Hum Mol Genet. 2016 Jun 15;25(12):2437-2450. doi: 10.1093/hmg/ddw109. Epub 2016 Apr 9. Hum Mol Genet. 2016. PMID: 27060332 Free PMC article.

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The Medial Orbitofrontal Cortex Regulates Sensitivity to Outcome Value.

Gourley SL, Zimmermann KS, Allen AG, Taylor JR. Gourley SL, et al. J Neurosci. 2016 Apr 20;36(16):4600-13. doi: 10.1523/JNEUROSCI.4253-15.2016. J Neurosci. 2016. PMID: 27098701 Free PMC article.

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MANF regulates hypothalamic control of food intake and body weight.

Yang S, Yang H, Chang R, Yin P, Yang Y, Yang W, Huang S, Gaertig MA, Li S, Li XJ. Yang S, et al. Nat Commun. 2017 Sep 18;8(1):579. doi: 10.1038/s41467-017-00750-x. Nat Commun. 2017. PMID: 28924165 Free PMC article.

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The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain.

Corgiat EB, List SM, Rounds JC, Corbett AH, Moberg KH. Corgiat EB, et al. J Biol Chem. 2021 Jul;297(1):100877. doi: 10.1016/j.jbc.2021.100877. Epub 2021 Jun 15. J Biol Chem. 2021. PMID: 34139237 Free PMC article.

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Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting.

Suciu SK, Long AB, Caspary T. Suciu SK, et al. Genetics. 2021 Aug 9;218(4):iyab084. doi: 10.1093/genetics/iyab084. Genetics. 2021. PMID: 34132778 Free PMC article.

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Thalamostriatal and cerebellothalamic pathways in a songbird, the Bengalese finch.

Nicholson DA, Roberts TF, Sober SJ. Nicholson DA, et al. J Comp Neurol. 2018 Jun 15;526(9):1550-1570. doi: 10.1002/cne.24428. Epub 2018 Apr 6. J Comp Neurol. 2018. PMID: 29520771 Free PMC article.

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Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction.

Thomas KT, Anderson BR, Shah N, Zimmer SE, Hawkins D, Valdez AN, Gu Q, Bassell GJ. Thomas KT, et al. Cell Rep. 2017 Jul 5;20(1):1-12. doi: 10.1016/j.celrep.2017.06.038. Cell Rep. 2017. PMID: 28683304 Free PMC article.

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Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.

Choi I, Beedholm K, Dam VS, Bae SH, Noble DJ, Garraway SM, Aalkjaer C, Boedtkjer E. Choi I, et al. Behav Brain Res. 2021 Mar 5;401:113065. doi: 10.1016/j.bbr.2020.113065. Epub 2020 Dec 13. Behav Brain Res. 2021. PMID: 33321164 Free PMC article.

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Ex vivo live imaging of single cell divisions in mouse neuroepithelium.

Piotrowska-Nitsche K, Caspary T. Piotrowska-Nitsche K, et al. J Vis Exp. 2013 Apr 30;(74):e4439. doi: 10.3791/4439. J Vis Exp. 2013. PMID: 23666396 Free PMC article.

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The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly.

Donlin-Asp PG, Fallini C, Campos J, Chou CC, Merritt ME, Phan HC, Bassell GJ, Rossoll W. Donlin-Asp PG, et al. Cell Rep. 2017 Feb 14;18(7):1660-1673. doi: 10.1016/j.celrep.2017.01.059. Cell Rep. 2017. PMID: 28199839 Free PMC article.

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Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease.

Abreha MH, Dammer EB, Ping L, Zhang T, Duong DM, Gearing M, Lah JJ, Levey AI, Seyfried NT. Abreha MH, et al. Proteomics. 2018 Oct;18(20):e1800108. doi: 10.1002/pmic.201800108. Proteomics. 2018. PMID: 30230243 Free PMC article.

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Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer's disease.

Zhang Q, Ma C, Chin LS, Li L. Zhang Q, et al. Sci Adv. 2020 Oct 2;6(40):eabc5802. doi: 10.1126/sciadv.abc5802. Print 2020 Oct. Sci Adv. 2020. PMID: 33008897 Free PMC article.

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