Verstegen MMA - Search Results

1

Rescue of chloride and bicarbonate transport by elexacaftor-ivacaftor-tezacaftor in organoid-derived CF intestinal and cholangiocyte monolayers.

Bijvelds MJC, Roos FJM, Meijsen KF, Roest HP, Verstegen MMA, Janssens HM, van der Laan LJW, de Jonge HR. Bijvelds MJC, et al. Among authors: verstegen mma. J Cyst Fibros. 2022 May;21(3):537-543. doi: 10.1016/j.jcf.2021.12.006. Epub 2021 Dec 23. J Cyst Fibros. 2022. PMID: 34922851 Free article.

2

Mobilization of hepatic mesenchymal stem cells from human liver grafts.

Pan Q, Fouraschen SM, Kaya FS, Verstegen MM, Pescatori M, Stubbs AP, van Ijcken W, van der Sloot A, Smits R, Kwekkeboom J, Metselaar HJ, Kazemier G, de Jonge J, Tilanus HW, Wagemaker G, Janssen HL, van der Laan LJ. Pan Q, et al. Liver Transpl. 2011 May;17(5):596-609. doi: 10.1002/lt.22260. Liver Transpl. 2011. PMID: 21506248 Free article.

3

No evidence for circulating mesenchymal stem cells in patients with organ injury.

Hoogduijn MJ, Verstegen MM, Engela AU, Korevaar SS, Roemeling-van Rhijn M, Merino A, Franquesa M, de Jonge J, Ijzermans JN, Weimar W, Betjes MG, Baan CC, van der Laan LJ. Hoogduijn MJ, et al. Stem Cells Dev. 2014 Oct 1;23(19):2328-35. doi: 10.1089/scd.2014.0269. Epub 2014 Aug 25. Stem Cells Dev. 2014. PMID: 25105211

4

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H. Huch M, et al. Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18. Cell. 2015. PMID: 25533785 Free PMC article.

5

Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses.

de Mare-Bredemeijer EL, Mancham S, Verstegen MM, de Ruiter PE, van Gent R, O'Neill D, Tilanus HW, Metselaar HJ, de Jonge J, Kwekkeboom J, Hall SR, van der Laan LJ. de Mare-Bredemeijer EL, et al. Stem Cells Dev. 2015 Jun 15;24(12):1436-47. doi: 10.1089/scd.2014.0485. Epub 2015 Apr 28. Stem Cells Dev. 2015. PMID: 25744002

6

Gene therapies for hepatitis C virus.

Verstegen MM, Pan Q, van der Laan LJ. Verstegen MM, et al. Adv Exp Med Biol. 2015;848:1-29. doi: 10.1007/978-1-4939-2432-5_1. Adv Exp Med Biol. 2015. PMID: 25757613 Review.

7

Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury.

Fouraschen SM, Wolf JH, van der Laan LJ, de Ruiter PE, Hancock WW, van Kooten JP, Verstegen MM, Olthoff KM, de Jonge J. Fouraschen SM, et al. J Immunol Res. 2015;2015:202975. doi: 10.1155/2015/202975. Epub 2015 Aug 24. J Immunol Res. 2015. PMID: 26380314 Free PMC article.

8

Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow.

Malagola E, Teunissen M, van der Laan LJ, Verstegen MM, Schotanus BA, van Steenbeek FG, Penning LC, van Wolferen ME, Tryfonidou MA, Spee B. Malagola E, et al. Stem Cells Dev. 2016 Jan 15;25(2):139-50. doi: 10.1089/scd.2015.0125. Epub 2015 Dec 14. Stem Cells Dev. 2016. PMID: 26462417 Free PMC article.

9

Tissue-specific mutation accumulation in human adult stem cells during life.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R. Blokzijl F, et al. Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3. Nature. 2016. PMID: 27698416 Free PMC article.

10

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.

Tüysüz N, van Bloois L, van den Brink S, Begthel H, Verstegen MM, Cruz LJ, Hui L, van der Laan LJ, de Jonge J, Vries R, Braakman E, Mastrobattista E, Cornelissen JJ, Clevers H, Ten Berge D. Tüysüz N, et al. Nat Commun. 2017 Mar 6;8:14578. doi: 10.1038/ncomms14578. Nat Commun. 2017. PMID: 28262686 Free PMC article.

11

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.

Kruitwagen HS, Oosterhoff LA, Vernooij IGWH, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B. Kruitwagen HS, et al. Among authors: verstegen mma. Stem Cell Reports. 2017 Apr 11;8(4):822-830. doi: 10.1016/j.stemcr.2017.02.015. Epub 2017 Mar 23. Stem Cell Reports. 2017. PMID: 28344000 Free PMC article.

12

From organoids to organs: Bioengineering liver grafts from hepatic stem cells and matrix.

Willemse J, Lieshout R, van der Laan LJW, Verstegen MMA. Willemse J, et al. Among authors: verstegen mma. Best Pract Res Clin Gastroenterol. 2017 Apr;31(2):151-159. doi: 10.1016/j.bpg.2017.03.003. Epub 2017 Apr 12. Best Pract Res Clin Gastroenterol. 2017. PMID: 28624103 Review.

13

Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds.

Verstegen MMA, Willemse J, van den Hoek S, Kremers GJ, Luider TM, van Huizen NA, Willemssen FEJA, Metselaar HJ, IJzermans JNM, van der Laan LJW, de Jonge J. Verstegen MMA, et al. Stem Cells Dev. 2017 Sep 15;26(18):1304-1315. doi: 10.1089/scd.2017.0095. Epub 2017 Jul 31. Stem Cells Dev. 2017. PMID: 28665233

14

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.

Cao W, Chen K, Bolkestein M, Yin Y, Verstegen MMA, Bijvelds MJC, Wang W, Tuysuz N, Ten Berge D, Sprengers D, Metselaar HJ, van der Laan LJW, Kwekkeboom J, Smits R, Peppelenbosch MP, Pan Q. Cao W, et al. Among authors: verstegen mma. Gastroenterology. 2017 Oct;153(4):1133-1147. doi: 10.1053/j.gastro.2017.07.006. Epub 2017 Jul 14. Gastroenterology. 2017. PMID: 28716722

15

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.

Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M. Broutier L, et al. Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13. Nat Med. 2017. PMID: 29131160 Free PMC article.

16

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors.

Cao W, Liu J, Wang L, Li M, Verstegen MMA, Yin Y, Ma B, Chen K, Bolkestein M, Sprengers D, van der Laan LJW, Doukas M, Kwekkeboom J, Smits R, Peppelenbosch MP, Pan Q. Cao W, et al. Among authors: verstegen mma. Carcinogenesis. 2019 Mar 12;40(1):145-154. doi: 10.1093/carcin/bgy129. Carcinogenesis. 2019. PMID: 30289434

17

Experimental models to unravel the molecular pathogenesis, cell of origin and stem cell properties of cholangiocarcinoma.

Vicent S, Lieshout R, Saborowski A, Verstegen MMA, Raggi C, Recalcati S, Invernizzi P, van der Laan LJW, Alvaro D, Calvisi DF, Cardinale V. Vicent S, et al. Among authors: verstegen mma. Liver Int. 2019 May;39 Suppl 1:79-97. doi: 10.1111/liv.14094. Liver Int. 2019. PMID: 30851232 Free article. Review.

18

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective.

Shi S, Verstegen MMA, Mezzanotte L, de Jonge J, Löwik CWGM, van der Laan LJW. Shi S, et al. Among authors: verstegen mma. Liver Transpl. 2019 Jul;25(7):1091-1104. doi: 10.1002/lt.25488. Liver Transpl. 2019. PMID: 31077562 Free PMC article. Review.

19

First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion.

Verstegen MMA, Mezzanotte L, Ridwan RY, Wang K, de Haan J, Schurink IJ, Sierra Parraga JM, Hoogduijn M, Kessler BM, Huang H, Hall SRR, Ijzermans JNM, Löwik CWGM, van der Laan LJW, de Jonge J. Verstegen MMA, et al. Transplantation. 2020 Jan;104(1):e5-e7. doi: 10.1097/TP.0000000000002986. Transplantation. 2020. PMID: 31609902 Free article. No abstract available.

20

Bioengineering Liver Transplantation.

Verstegen MMA, Spee B, van der Laan LJW. Verstegen MMA, et al. Bioengineering (Basel). 2019 Oct 16;6(4):96. doi: 10.3390/bioengineering6040096. Bioengineering (Basel). 2019. PMID: 31623066 Free PMC article.

21

Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment.

van Tienderen GS, Groot Koerkamp B, IJzermans JNM, van der Laan LJW, Verstegen MMA. van Tienderen GS, et al. Among authors: verstegen mma. Cancers (Basel). 2019 Nov 1;11(11):1706. doi: 10.3390/cancers11111706. Cancers (Basel). 2019. PMID: 31683901 Free PMC article. Review.

22

Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells.

Schneeberger K, Sánchez-Romero N, Ye S, van Steenbeek FG, Oosterhoff LA, Pla Palacin I, Chen C, van Wolferen ME, van Tienderen G, Lieshout R, Colemonts-Vroninks H, Schene I, Hoekstra R, Verstegen MMA, van der Laan LJW, Penning LC, Fuchs SA, Clevers H, De Kock J, Baptista PM, Spee B. Schneeberger K, et al. Among authors: verstegen mma. Hepatology. 2020 Jul;72(1):257-270. doi: 10.1002/hep.31037. Epub 2020 Apr 8. Hepatology. 2020. PMID: 31715015 Free PMC article.

23

Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens.

Hötte K, Koch M, Hof L, Tuppi M, Moreth T, Verstegen MMA, van der Laan LJW, Stelzer EHK, Pampaloni F. Hötte K, et al. Among authors: verstegen mma. Sci Rep. 2019 Nov 21;9(1):17292. doi: 10.1038/s41598-019-53380-2. Sci Rep. 2019. PMID: 31754183 Free PMC article.

24

Fast, robust and effective decellularization of whole human livers using mild detergents and pressure controlled perfusion.

Willemse J, Verstegen MMA, Vermeulen A, Schurink IJ, Roest HP, van der Laan LJW, de Jonge J. Willemse J, et al. Among authors: verstegen mma. Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110200. doi: 10.1016/j.msec.2019.110200. Epub 2019 Sep 12. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 31923991

25

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth.

Li M, Wang L, Wang Y, Zhang S, Zhou G, Lieshout R, Ma B, Liu J, Qu C, Verstegen MMA, Sprengers D, Kwekkeboom J, van der Laan LJW, Cao W, Peppelenbosch MP, Pan Q. Li M, et al. Among authors: verstegen mma. Cells. 2020 Jan 4;9(1):121. doi: 10.3390/cells9010121. Cells. 2020. PMID: 31947947 Free PMC article.

26

LGR5 marks targetable tumor-initiating cells in mouse liver cancer.

Cao W, Li M, Liu J, Zhang S, Noordam L, Verstegen MMA, Wang L, Ma B, Li S, Wang W, Bolkestein M, Doukas M, Chen K, Ma Z, Bruno M, Sprengers D, Kwekkeboom J, van der Laan LJW, Smits R, Peppelenbosch MP, Pan Q. Cao W, et al. Among authors: verstegen mma. Nat Commun. 2020 Apr 23;11(1):1961. doi: 10.1038/s41467-020-15846-0. Nat Commun. 2020. PMID: 32327656 Free PMC article.

27

Characterization of gut-homing molecules in non-endstage livers of patients with primary sclerosing cholangitis and inflammatory bowel disease.

de Krijger M, Visseren T, Wildenberg ME, Hooijer GKJ, Verstegen MMA, van der Laan LJW, de Jonge WJ, Verheij J, Ponsioen CY. de Krijger M, et al. Among authors: verstegen mma. J Transl Autoimmun. 2020 Apr 9;3:100054. doi: 10.1016/j.jtauto.2020.100054. eCollection 2020. J Transl Autoimmun. 2020. PMID: 32743534 Free PMC article.

28

Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development.

Chen S, Li P, Wang Y, Yin Y, de Ruiter PE, Verstegen MMA, Peppelenbosch MP, van der Laan LJW, Pan Q. Chen S, et al. Among authors: verstegen mma. mBio. 2020 Aug 25;11(4):e01968-20. doi: 10.1128/mBio.01968-20. mBio. 2020. PMID: 32843549 Free PMC article.

29

Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.

Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, Lieshout R, Verstegen MMA, Ma B, Su J, Yang Q, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W. Liu J, et al. Among authors: verstegen mma. Cell Mol Gastroenterol Hepatol. 2021;11(2):407-431. doi: 10.1016/j.jcmgh.2020.09.003. Epub 2020 Sep 12. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32932015 Free PMC article.

30

The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer.

Zhang R, Noordam L, Ou X, Ma B, Li Y, Das P, Shi S, Liu J, Wang L, Li P, Verstegen MMA, Reddy DS, van der Laan LJW, Peppelenbosch MP, Kwekkeboom J, Smits R, Pan Q. Zhang R, et al. Among authors: verstegen mma. Liver Int. 2021 Jan;41(1):206-219. doi: 10.1111/liv.14692. Epub 2020 Oct 20. Liver Int. 2021. PMID: 33084231 Free PMC article.

31

Prime editing for functional repair in patient-derived disease models.

Schene IF, Joore IP, Oka R, Mokry M, van Vugt AHM, van Boxtel R, van der Doef HPJ, van der Laan LJW, Verstegen MMA, van Hasselt PM, Nieuwenhuis EES, Fuchs SA. Schene IF, et al. Among authors: verstegen mma. Nat Commun. 2020 Oct 23;11(1):5352. doi: 10.1038/s41467-020-19136-7. Nat Commun. 2020. PMID: 33097693 Free PMC article.

32

Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish.

Willemse J, Roos FJM, Voogt IJ, Schurink IJ, Bijvelds M, de Jonge HR, van der Laan LJW, de Jonge J, Verstegen MMA. Willemse J, et al. Among authors: verstegen mma. Biotechnol Bioeng. 2021 Feb;118(2):836-851. doi: 10.1002/bit.27613. Epub 2020 Nov 9. Biotechnol Bioeng. 2021. PMID: 33118611 Free PMC article.

33

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.

Verstegen MMA, Roos FJM, Burka K, Gehart H, Jager M, de Wolf M, Bijvelds MJC, de Jonge HR, Ardisasmita AI, van Huizen NA, Roest HP, de Jonge J, Koch M, Pampaloni F, Fuchs SA, Schene IF, Luider TM, van der Doef HPJ, Bodewes FAJA, de Kleine RHJ, Spee B, Kremers GJ, Clevers H, IJzermans JNM, Cuppen E, van der Laan LJW. Verstegen MMA, et al. Sci Rep. 2020 Dec 14;10(1):21900. doi: 10.1038/s41598-020-79082-8. Sci Rep. 2020. PMID: 33318612 Free PMC article.

34

Long-Term Perfusion of the Liver Outside the Body: Warming Up for Ex Vivo Therapies?

Schurink IJ, Willemse J, Verstegen MMA, van der Laan LJW, de Jonge J. Schurink IJ, et al. Among authors: verstegen mma. Hepatology. 2020 Oct;72(4):1485-1487. doi: 10.1002/hep.31474. Hepatology. 2020. PMID: 33464565 Free PMC article. No abstract available.

35

Mitochondrial Dysfunction and Oxidative Stress in Liver Transplantation and Underlying Diseases: New Insights and Therapeutics.

Shi S, Wang L, van der Laan LJW, Pan Q, Verstegen MMA. Shi S, et al. Among authors: verstegen mma. Transplantation. 2021 Nov 1;105(11):2362-2373. doi: 10.1097/TP.0000000000003691. Transplantation. 2021. PMID: 33577251 Review.

36

Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis.

Hof L, Moreth T, Koch M, Liebisch T, Kurtz M, Tarnick J, Lissek SM, Verstegen MMA, van der Laan LJW, Huch M, Matthäus F, Stelzer EHK, Pampaloni F. Hof L, et al. Among authors: verstegen mma. BMC Biol. 2021 Feb 24;19(1):37. doi: 10.1186/s12915-021-00958-w. BMC Biol. 2021. PMID: 33627108 Free PMC article.

37

Human Bile Contains Cholangiocyte Organoid-Initiating Cells Which Expand as Functional Cholangiocytes in Non-canonical Wnt Stimulating Conditions.

Roos FJM, Verstegen MMA, Muñoz Albarinos L, Roest HP, Poley JW, Tetteroo GWM, IJzermans JNM, van der Laan LJW. Roos FJM, et al. Among authors: verstegen mma. Front Cell Dev Biol. 2021 Feb 9;8:630492. doi: 10.3389/fcell.2020.630492. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33634107 Free PMC article.

38

Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids.

Roos FJM, Bijvelds MJC, Verstegen MMA, Roest HP, Metselaar HJ, Polak WG, Jonge HR, IJzermans JNM, van der Laan LJW. Roos FJM, et al. Among authors: verstegen mma. Am J Physiol Gastrointest Liver Physiol. 2021 May 1;320(5):G741-G752. doi: 10.1152/ajpgi.00389.2020. Epub 2021 Mar 3. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 33655768 Free article.

39

Bile Duct Repair in Human Liver Grafts: Effective Cholangiocyte Organoid Engraftment and Plasticity.

van der Laan LJW, Roos FJM, Verstegen MMA. van der Laan LJW, et al. Among authors: verstegen mma. Hepatology. 2021 Oct;74(4):2287-2289. doi: 10.1002/hep.31877. Epub 2021 Jun 21. Hepatology. 2021. PMID: 33934393 Free PMC article. No abstract available.

40

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.

Marsee A, Roos FJM, Verstegen MMA; HPB Organoid Consortium; Gehart H, de Koning E, Lemaigre F, Forbes SJ, Peng WC, Huch M, Takebe T, Vallier L, Clevers H, van der Laan LJW, Spee B. Marsee A, et al. Among authors: verstegen mma. Cell Stem Cell. 2021 May 6;28(5):816-832. doi: 10.1016/j.stem.2021.04.005. Cell Stem Cell. 2021. PMID: 33961769 Free article. Review.

41

Letter to the Editor: High Mobility Group Box Protein 1 Release Is an Identified Driver of Inflammation in the Pathogenesis of Biliary Atresia.

Shi S, Chen S, Verstegen MMA, Pan Q, van der Laan LJW. Shi S, et al. Among authors: verstegen mma. Hepatology. 2021 Nov;74(5):2920-2921. doi: 10.1002/hep.32026. Epub 2021 Jul 29. Hepatology. 2021. PMID: 34164831 Free PMC article. No abstract available.

42

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma.

De Crignis E, Hossain T, Romal S, Carofiglio F, Moulos P, Khalid MM, Rao S, Bazrafshan A, Verstegen MM, Pourfarzad F, Koutsothanassis C, Gehart H, Kan TW, Palstra RJ, Boucher C, IJzermans JN, Huch M, Boj SF, Vries R, Clevers H, van der Laan LJ, Hatzis P, Mahmoudi T. De Crignis E, et al. Elife. 2021 Jul 30;10:e60747. doi: 10.7554/eLife.60747. Elife. 2021. PMID: 34328417 Free PMC article.

43

The potential and limitations of intrahepatic cholangiocyte organoids to study inborn errors of metabolism.

Lehmann V, Schene IF, Ardisasmita AI, Liv N, Veenendaal T, Klumperman J, van der Doef HPJ, Verkade HJ, Verstegen MMA, van der Laan LJW, Jans JJM, Verhoeven-Duif NM, van Hasselt PM, Nieuwenhuis EES, Spee B, Fuchs SA. Lehmann V, et al. Among authors: verstegen mma. J Inherit Metab Dis. 2022 Mar;45(2):353-365. doi: 10.1002/jimd.12450. Epub 2021 Nov 3. J Inherit Metab Dis. 2022. PMID: 34671987 Free PMC article.

44

Recapitulating Cholangiopathy-Associated Necroptotic Cell Death In Vitro Using Human Cholangiocyte Organoids.

Shi S, Verstegen MMA, Roest HP, Ardisasmita AI, Cao W, Roos FJM, de Ruiter PE, Niemeijer M, Pan Q, IJzermans JNM, van der Laan LJW. Shi S, et al. Among authors: verstegen mma. Cell Mol Gastroenterol Hepatol. 2022;13(2):541-564. doi: 10.1016/j.jcmgh.2021.10.009. Epub 2021 Oct 23. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34700031 Free PMC article.

45

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.

Nguyen L, Jager M, Lieshout R, de Ruiter PE, Locati MD, Besselink N, van der Roest B, Janssen R, Boymans S, de Jonge J, IJzermans JNM, Doukas M, Verstegen MMA, van Boxtel R, van der Laan LJW, Cuppen E, Kuijk E. Nguyen L, et al. Among authors: verstegen mma. Commun Biol. 2021 Nov 18;4(1):1301. doi: 10.1038/s42003-021-02839-y. Commun Biol. 2021. PMID: 34795391 Free PMC article.

46

Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro.

Roos FJM, Wu H, Willemse J, Lieshout R, Albarinos LAM, Kan YY, Poley JW, Bruno MJ, de Jonge J, Bártfai R, Marks H, IJzermans JNM, Verstegen MMA, van der Laan LJW. Roos FJM, et al. Among authors: verstegen mma. Clin Transl Med. 2021 Dec;11(12):e566. doi: 10.1002/ctm2.566. Clin Transl Med. 2021. PMID: 34954911 Free PMC article.

47

Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.

Li P, Li Y, Wang Y, Liu J, Lavrijsen M, Li Y, Zhang R, Verstegen MMA, Wang Y, Li TC, Ma Z, Kainov DE, Bruno MJ, de Man RA, van der Laan LJW, Peppelenbosch MP, Pan Q. Li P, et al. Among authors: verstegen mma. Sci Adv. 2022 Jan 21;8(3):eabj5908. doi: 10.1126/sciadv.abj5908. Epub 2022 Jan 19. Sci Adv. 2022. PMID: 35044825 Free PMC article.

48

Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids.

Wang L, Li M, Yu B, Shi S, Liu J, Zhang R, Ayada I, Verstegen MMA, van der Laan LJW, Peppelenbosch MP, Cao W, Pan Q. Wang L, et al. Among authors: verstegen mma. J Mol Med (Berl). 2022 Mar;100(3):471-484. doi: 10.1007/s00109-021-02176-x. Epub 2022 Jan 20. J Mol Med (Berl). 2022. PMID: 35059746

49

Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions.

van Tienderen GS, Li L, Broutier L, Saito Y, Inacio P, Huch M, Selaru FM, van der Laan LJW, Verstegen MMA. van Tienderen GS, et al. Among authors: verstegen mma. Cancer Cell. 2022 Mar 14;40(3):226-230. doi: 10.1016/j.ccell.2022.02.001. Epub 2022 Feb 10. Cancer Cell. 2022. PMID: 35148815 Free article.

50

Assessment of human leukocyte antigen matching algorithm PIRCHE-II on liver transplantation outcomes.

Kok G, Verstegen MMA, Houwen RHJ, Nieuwenhuis EES, Metselaar HJ, Polak WG, van der Laan LJW, Spierings E, den Hoed CM, Fuchs SA. Kok G, et al. Among authors: verstegen mma. Liver Transpl. 2022 Aug;28(8):1356-1366. doi: 10.1002/lt.26431. Epub 2022 Apr 25. Liver Transpl. 2022. PMID: 35152544 Free PMC article.

51

Design by Nature: Emerging Applications of Native Liver Extracellular Matrix for Cholangiocyte Organoid-Based Regenerative Medicine.

Willemse J, van der Laan LJW, de Jonge J, Verstegen MMA. Willemse J, et al. Among authors: verstegen mma. Bioengineering (Basel). 2022 Mar 7;9(3):110. doi: 10.3390/bioengineering9030110. Bioengineering (Basel). 2022. PMID: 35324799 Free PMC article. Review.

52

Human branching cholangiocyte organoids recapitulate functional bile duct formation.

Roos FJM, van Tienderen GS, Wu H, Bordeu I, Vinke D, Albarinos LM, Monfils K, Niesten S, Smits R, Willemse J, Rosmark O, Westergren-Thorsson G, Kunz DJ, de Wit M, French PJ, Vallier L, IJzermans JNM, Bartfai R, Marks H, Simons BD, van Royen ME, Verstegen MMA, van der Laan LJW. Roos FJM, et al. Among authors: verstegen mma. Cell Stem Cell. 2022 May 5;29(5):776-794.e13. doi: 10.1016/j.stem.2022.04.011. Cell Stem Cell. 2022. PMID: 35523140 Free article.

53

Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells.

Zhou G, Lieshout R, van Tienderen GS, de Ruiter V, van Royen ME, Boor PPC, Magré L, Desai J, Köten K, Kan YY, Ge Z, Campos Carrascosa L, Geuijen C, Sprengers D, van der Laan LJW, Verstegen MMA, Kwekkeboom J. Zhou G, et al. Among authors: verstegen mma. Br J Cancer. 2022 Sep;127(4):649-660. doi: 10.1038/s41416-022-01839-x. Epub 2022 May 21. Br J Cancer. 2022. PMID: 35597867 Free PMC article.

54

Liver Ischemia and Reperfusion Induce Periportal Expression of Necroptosis Executor pMLKL Which Is Associated With Early Allograft Dysfunction After Transplantation.

Shi S, Bonaccorsi-Riani E, Schurink I, van den Bosch T, Doukas M, Lila KA, Roest HP, Xhema D, Gianello P, de Jonge J, Verstegen MMA, van der Laan LJW. Shi S, et al. Among authors: verstegen mma. Front Immunol. 2022 May 17;13:890353. doi: 10.3389/fimmu.2022.890353. eCollection 2022. Front Immunol. 2022. PMID: 35655777 Free PMC article.

55

Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification.

Lieshout R, Faria AVS, Peppelenbosch MP, van der Laan LJW, Verstegen MMA, Fuhler GM. Lieshout R, et al. Among authors: verstegen mma. Mol Med. 2022 Jun 28;28(1):74. doi: 10.1186/s10020-022-00498-1. Mol Med. 2022. PMID: 35764936 Free PMC article.

56

The current status of stem cell-based therapies during ex vivo graft perfusion: An integrated review of four organs.

Luijmes SH, Verstegen MMA, Hoogduijn MJ, Seghers L, Minnee RC, Mahtab EAF, Taverne YJHJ, Reinders MEJ, van der Laan LJW, de Jonge J. Luijmes SH, et al. Among authors: verstegen mma. Am J Transplant. 2022 Dec;22(12):2723-2739. doi: 10.1111/ajt.17161. Epub 2022 Aug 25. Am J Transplant. 2022. PMID: 35896477 Free PMC article. Review.

57

Cholangiocarcinoma cell proliferation is enhanced in primary sclerosing cholangitis: A role for IL-17A.

Lieshout R, Kamp EJCA, Verstegen MMA, Doukas M, Dinjens WNM, Köten K, IJzermans JNM, Bruno MJ, Peppelenbosch MP, van der Laan LJW, de Vries AC. Lieshout R, et al. Among authors: verstegen mma. Int J Cancer. 2023 Jun 15;152(12):2607-2614. doi: 10.1002/ijc.34350. Epub 2022 Nov 17. Int J Cancer. 2023. PMID: 36346104

58

Extracellular matrix drives tumor organoids toward desmoplastic matrix deposition and mesenchymal transition.

van Tienderen GS, Rosmark O, Lieshout R, Willemse J, de Weijer F, Elowsson Rendin L, Westergren-Thorsson G, Doukas M, Groot Koerkamp B, van Royen ME, van der Laan LJ, Verstegen MM. van Tienderen GS, et al. Acta Biomater. 2023 Mar 1;158:115-131. doi: 10.1016/j.actbio.2022.11.038. Epub 2022 Nov 23. Acta Biomater. 2023. PMID: 36427688

59

Label-Free Imaging Analysis of Patient-Derived Cholangiocarcinoma Organoids after Sorafenib Treatment.

Koch M, Nickel S, Lieshout R, Lissek SM, Leskova M, van der Laan LJW, Verstegen MMA, Christ B, Pampaloni F. Koch M, et al. Among authors: verstegen mma. Cells. 2022 Nov 15;11(22):3613. doi: 10.3390/cells11223613. Cells. 2022. PMID: 36429040 Free PMC article.

60

Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules.

van Tienderen GS, Willemse J, van Loo B, van Hengel EVA, de Jonge J, van der Laan LJW, Leijten J, Verstegen MMA. van Tienderen GS, et al. Among authors: verstegen mma. Cells. 2022 Nov 18;11(22):3657. doi: 10.3390/cells11223657. Cells. 2022. PMID: 36429084 Free PMC article.

61

Modeling bile duct ischemia and reoxygenation injury in human cholangiocyte organoids for screening of novel cholangio-protective agents.

Shi S, Roest HP, van den Bosch TPP, Bijvelds MJC, Boehnert MU, de Jonge J, Dekker SO, de Vries AAF, de Jonge HR, Verstegen MMA, van der Laan LJW. Shi S, et al. Among authors: verstegen mma. EBioMedicine. 2023 Feb;88:104431. doi: 10.1016/j.ebiom.2022.104431. Epub 2023 Jan 4. EBioMedicine. 2023. PMID: 36608526 Free PMC article.

62

Tumor decellularization reveals proteomic and mechanical characteristics of the extracellular matrix of primary liver cancer.

van Tienderen GS, Conboy J, Muntz I, Willemse J, Tieleman J, Monfils K, Schurink IJ, Demmers JAA, Doukas M, Koenderink GH, van der Laan LJW, Verstegen MMA. van Tienderen GS, et al. Among authors: verstegen mma. Biomater Adv. 2023 Mar;146:213289. doi: 10.1016/j.bioadv.2023.213289. Epub 2023 Jan 18. Biomater Adv. 2023. PMID: 36724550 Free article.

63

Modelling metastatic colonization of cholangiocarcinoma organoids in decellularized lung and lymph nodes.

van Tienderen GS, van Beek MEA, Schurink IJ, Rosmark O, Roest HP, Tieleman J, Demmers J, Muntz I, Conboy J, Westergren-Thorsson G, Koenderink G, van der Laan LJ, Verstegen MMA. van Tienderen GS, et al. Among authors: verstegen mma. Front Oncol. 2023 Jan 18;12:1101901. doi: 10.3389/fonc.2022.1101901. eCollection 2022. Front Oncol. 2023. PMID: 36741736 Free PMC article.

64

Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies.

Magré L, Verstegen MMA, Buschow S, van der Laan LJW, Peppelenbosch M, Desai J. Magré L, et al. Among authors: verstegen mma. J Immunother Cancer. 2023 May;11(5):e006290. doi: 10.1136/jitc-2022-006290. J Immunother Cancer. 2023. PMID: 37220953 Free PMC article. Review.

65

Protocol for inducing branching morphogenesis in human cholangiocyte and cholangiocarcinoma organoids.

Ober K, Roos FJM, van Tienderen GS, Köten K, Klaassen A, Mi W, van der Laan LJW, Verstegen MMA. Ober K, et al. Among authors: verstegen mma. STAR Protoc. 2023 Sep 15;4(3):102431. doi: 10.1016/j.xpro.2023.102431. Epub 2023 Jul 9. STAR Protoc. 2023. PMID: 37432852 Free PMC article.

66

Endothelial Cell Replacement of Human Veins, Modeling Vascular Repair and Endothelial Cell Chimerism.

Tejeda-Mora H, den Hartog Y, Schurink IJ, Verstegen MMA, de Jonge J, van den Hoogen MWF, Baan CC, Minnee RC, Hoogduijn MJ, van der Laan LJW, Willemse J. Tejeda-Mora H, et al. Among authors: verstegen mma. Stem Cells Dev. 2024 Jan;33(1-2):27-42. doi: 10.1089/scd.2023.0142. Epub 2023 Dec 27. Stem Cells Dev. 2024. PMID: 37950716

67

Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions.

Guo H, Liu D, Liu K, Hou Y, Li C, Li Q, Ding X, Verstegen MMA, Zhang J, Wang L, Ding Y, Tang R, Pan X, Zheng K, van der Laan LJW, Pan Q, Wang W. Guo H, et al. Among authors: verstegen mma. Virol Sin. 2024 Feb;39(1):123-133. doi: 10.1016/j.virs.2023.11.006. Epub 2023 Nov 19. Virol Sin. 2024. PMID: 37984761 Free PMC article.

68

The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets.

Sleeboom JJF, van Tienderen GS, Schenke-Layland K, van der Laan LJW, Khalil AA, Verstegen MMA. Sleeboom JJF, et al. Among authors: verstegen mma. Sci Transl Med. 2024 Jan 3;16(728):eadg3840. doi: 10.1126/scitranslmed.adg3840. Epub 2024 Jan 3. Sci Transl Med. 2024. PMID: 38170791 Review.

69

Cholangiocyte organoids to study drug-induced injury.

Wang Z, Xing C, van der Laan LJW, Verstegen MMA, Spee B, Masereeuw R. Wang Z, et al. Among authors: verstegen mma. Stem Cell Res Ther. 2024 Mar 13;15(1):78. doi: 10.1186/s13287-024-03692-6. Stem Cell Res Ther. 2024. PMID: 38475870 Free PMC article.

70

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance.

Calvisi DF, Boulter L, Vaquero J, Saborowski A, Fabris L, Rodrigues PM, Coulouarn C, Castro RE, Segatto O, Raggi C, van der Laan LJW, Carpino G, Goeppert B, Roessler S, Kendall TJ, Evert M, Gonzalez-Sanchez E, Valle JW, Vogel A, Bridgewater J, Borad MJ, Gores GJ, Roberts LR, Marin JJG, Andersen JB, Alvaro D, Forner A, Banales JM, Cardinale V, Macias RIR, Vicent S, Chen X, Braconi C, Verstegen MMA, Fouassier L; CCA Model Consortium. Calvisi DF, et al. Among authors: verstegen mma. Nat Rev Gastroenterol Hepatol. 2023 Jul;20(7):462-480. doi: 10.1038/s41575-022-00739-y. Epub 2023 Feb 8. Nat Rev Gastroenterol Hepatol. 2023. PMID: 36755084 Free article. Review.

71

Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes.

Terpstra W, Leenen PJ, van den Bos C, Prins A, Loenen WA, Verstegen MM, van Wyngaardt S, van Rooijen N, Wognum AW, Wagemaker G, Wielenga JJ, Löwenberg B. Terpstra W, et al. Leukemia. 1997 Jul;11(7):1049-54. doi: 10.1038/sj.leu.2400694. Leukemia. 1997. PMID: 9204990

72

Thrombopoietin is a major limiting factor for selective outgrowth of human umbilical cord blood cells in non-obese diabetic/severe combined immunodeficient recipient mice.

Verstegen MM, Wognum AW, Wagemaker G. Verstegen MM, et al. Br J Haematol. 2003 Sep;122(5):837-46. doi: 10.1046/j.1365-2141.2003.04498.x. Br J Haematol. 2003. PMID: 12930398 Free article.

73

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ. Pike-Overzet K, et al. Leukemia. 2007 Apr;21(4):754-63. doi: 10.1038/sj.leu.2404563. Epub 2007 Feb 1. Leukemia. 2007. PMID: 17268520

74

Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome.

van Til NP, Sarwari R, Visser TP, Hauer J, Lagresle-Peyrou C, van der Velden G, Malshetty V, Cortes P, Jollet A, Danos O, Cassani B, Zhang F, Thrasher AJ, Fontana E, Poliani PL, Cavazzana M, Verstegen MM, Villa A, Wagemaker G. van Til NP, et al. J Allergy Clin Immunol. 2014 Apr;133(4):1116-23. doi: 10.1016/j.jaci.2013.10.009. Epub 2013 Dec 9. J Allergy Clin Immunol. 2014. PMID: 24332219

75

Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: evidence for accessory cell involvement in expansion of immature CD34+CD38- cells.

Verstegen MM, van Hennik PB, Terpstra W, van den Bos C, Wielenga JJ, van Rooijen N, Ploemacher RE, Wagemaker G, Wognum AW. Verstegen MM, et al. Blood. 1998 Mar 15;91(6):1966-76. Blood. 1998. PMID: 9490679 Free article.

76

Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice.

van Hennik PB, Verstegen MM, Bierhuizen MF, Limón A, Wognum AW, Cancelas JA, Barquinero J, Ploemacher RE, Wagemaker G. van Hennik PB, et al. Blood. 1998 Dec 1;92(11):4013-22. Blood. 1998. PMID: 9834203 Free article.

77

Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype.

van Til NP, Stok M, Aerts Kaya FS, de Waard MC, Farahbakhshian E, Visser TP, Kroos MA, Jacobs EH, Willart MA, van der Wegen P, Scholte BJ, Lambrecht BN, Duncker DJ, van der Ploeg AT, Reuser AJ, Verstegen MM, Wagemaker G. van Til NP, et al. Blood. 2010 Jul 1;115(26):5329-37. doi: 10.1182/blood-2009-11-252874. Epub 2010 Apr 12. Blood. 2010. PMID: 20385789 Free article.

78

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

Homminga I, Pieters R, Langerak AW, de Rooi JJ, Stubbs A, Verstegen M, Vuerhard M, Buijs-Gladdines J, Kooi C, Klous P, van Vlierberghe P, Ferrando AA, Cayuela JM, Verhaaf B, Beverloo HB, Horstmann M, de Haas V, Wiekmeijer AS, Pike-Overzet K, Staal FJ, de Laat W, Soulier J, Sigaux F, Meijerink JP. Homminga I, et al. Cancer Cell. 2011 Apr 12;19(4):484-97. doi: 10.1016/j.ccr.2011.02.008. Cancer Cell. 2011. PMID: 21481790 Free article.

79

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

Deichmann A, Brugman MH, Bartholomae CC, Schwarzwaelder K, Verstegen MM, Howe SJ, Arens A, Ott MG, Hoelzer D, Seger R, Grez M, Hacein-Bey-Abina S, Cavazzana-Calvo M, Fischer A, Paruzynski A, Gabriel R, Glimm H, Abel U, Cattoglio C, Mavilio F, Cassani B, Aiuti A, Dunbar CE, Baum C, Gaspar HB, Thrasher AJ, von Kalle C, Schmidt M, Wagemaker G. Deichmann A, et al. Mol Ther. 2011 Nov;19(11):2031-9. doi: 10.1038/mt.2011.178. Epub 2011 Aug 23. Mol Ther. 2011. PMID: 21862999 Free PMC article.

80

Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells.

Farahbakhshian E, Verstegen MM, Visser TP, Kheradmandkia S, Geerts D, Arshad S, Riaz N, Grosveld F, van Til NP, Meijerink JP. Farahbakhshian E, et al. PLoS One. 2014 Aug 29;9(8):e105642. doi: 10.1371/journal.pone.0105642. eCollection 2014. PLoS One. 2014. PMID: 25170927 Free PMC article.

81

Multilineage outgrowth of both malignant and normal hemopoietic progenitor cells from individual chronic myeloid leukemia patients in immunodeficient mice.

Verstegen MM, Cornelissen JJ, Terpstra W, Wagemaker G, Wognum AW. Verstegen MM, et al. Leukemia. 1999 Apr;13(4):618-28. doi: 10.1038/sj.leu.2401366. Leukemia. 1999. PMID: 10214871

82

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors.

Schambach A, Mueller D, Galla M, Verstegen MM, Wagemaker G, Loew R, Baum C, Bohne J. Schambach A, et al. Gene Ther. 2006 Nov;13(21):1524-33. doi: 10.1038/sj.gt.3302807. Epub 2006 Jun 8. Gene Ther. 2006. PMID: 16763662

83

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study.

de Mos M, Koevoet WJ, Jahr H, Verstegen MM, Heijboer MP, Kops N, van Leeuwen JP, Weinans H, Verhaar JA, van Osch GJ. de Mos M, et al. BMC Musculoskelet Disord. 2007 Feb 23;8:16. doi: 10.1186/1471-2474-8-16. BMC Musculoskelet Disord. 2007. PMID: 17319938 Free PMC article.

84

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.

Huston MW, van Til NP, Visser TP, Arshad S, Brugman MH, Cattoglio C, Nowrouzi A, Li Y, Schambach A, Schmidt M, Baum C, von Kalle C, Mavilio F, Zhang F, Blundell MP, Thrasher AJ, Verstegen MM, Wagemaker G. Huston MW, et al. Mol Ther. 2011 Oct;19(10):1867-77. doi: 10.1038/mt.2011.127. Epub 2011 Jul 12. Mol Ther. 2011. PMID: 21750532 Free PMC article.

85

Gene therapy: is IL2RG oncogenic in T-cell development?

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ. Pike-Overzet K, et al. Nature. 2006 Sep 21;443(7109):E5; discussion E6-7. doi: 10.1038/nature05218. Nature. 2006. PMID: 16988660

86

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.

Schambach A, Schiedlmeier B, Kühlcke K, Verstegen M, Margison GP, Li Z, Kamino K, Bohne J, Alexandrov A, Hermann FG, von Laer D, Baum C. Schambach A, et al. Gene Ther. 2006 Jul;13(13):1037-47. doi: 10.1038/sj.gt.3302755. Epub 2006 Mar 16. Gene Ther. 2006. PMID: 16541120

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