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Page 1
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Desikan RS, et al. Among authors: besser l. PLoS Med. 2017 Mar 21;14(3):e1002258. doi: 10.1371/journal.pmed.1002258. eCollection 2017 Mar. PLoS Med. 2017. PMID: 28323831 Free PMC article.
Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study.
Monsell SE, Dodge HH, Zhou XH, Bu Y, Besser LM, Mock C, Hawes SE, Kukull WA, Weintraub S; Neuropsychology Work Group Advisory to the Clinical Task Force. Monsell SE, et al. Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):134-9. doi: 10.1097/WAD.0000000000000111. Alzheimer Dis Assoc Disord. 2016. PMID: 26485498 Free PMC article.
Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.
Bonham LW, Geier EG, Fan CC, Leong JK, Besser L, Kukull WA, Kornak J, Andreassen OA, Schellenberg GD, Rosen HJ, Dillon WP, Hess CP, Miller BL, Dale AM, Desikan RS, Yokoyama JS. Bonham LW, et al. Among authors: besser l. Ann Clin Transl Neurol. 2016 Aug 26;3(9):668-77. doi: 10.1002/acn3.333. eCollection 2016 Sep. Ann Clin Transl Neurol. 2016. PMID: 27648456 Free PMC article.
Factors Influencing Successful Lumbar Puncture in Alzheimer Research.
Moulder KL, Besser LM, Beekly D, Blennow K, Kukull W, Morris JC. Moulder KL, et al. Among authors: besser lm. Alzheimer Dis Assoc Disord. 2017 Oct-Dec;31(4):287-294. doi: 10.1097/WAD.0000000000000209. Alzheimer Dis Assoc Disord. 2017. PMID: 28891819 Free PMC article.
Polygenic hazard scores in preclinical Alzheimer disease.
Tan CH, Hyman BT, Tan JJX, Hess CP, Dillon WP, Schellenberg GD, Besser LM, Kukull WA, Kauppi K, McEvoy LK, Andreassen OA, Dale AM, Fan CC, Desikan RS. Tan CH, et al. Ann Neurol. 2017 Sep;82(3):484-488. doi: 10.1002/ana.25029. Ann Neurol. 2017. PMID: 28940650 Free PMC article.
Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS).
Weintraub S, Besser L, Dodge HH, Teylan M, Ferris S, Goldstein FC, Giordani B, Kramer J, Loewenstein D, Marson D, Mungas D, Salmon D, Welsh-Bohmer K, Zhou XH, Shirk SD, Atri A, Kukull WA, Phelps C, Morris JC. Weintraub S, et al. Among authors: besser l. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):10-17. doi: 10.1097/WAD.0000000000000223. Alzheimer Dis Assoc Disord. 2018. PMID: 29240561 Free PMC article.
Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.
Besser L, Kukull W, Knopman DS, Chui H, Galasko D, Weintraub S, Jicha G, Carlsson C, Burns J, Quinn J, Sweet RA, Rascovsky K, Teylan M, Beekly D, Thomas G, Bollenbeck M, Monsell S, Mock C, Zhou XH, Thomas N, Robichaud E, Dean M, Hubbard J, Jacka M, Schwabe-Fry K, Wu J, Phelps C, Morris JC; Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers. Besser L, et al. Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):351-358. doi: 10.1097/WAD.0000000000000279. Alzheimer Dis Assoc Disord. 2018. PMID: 30376508 Free PMC article. Review.
Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly.
Lee S, Zhou X, Gao Y, Vardarajan B, Reyes-Dumeyer D, Rajan KB, Wilson RS, Evans DA, Besser LM, Kukull WA, Bennett DA, Brickman AM, Schupf N, Mayeux R, Barral S. Lee S, et al. PLoS One. 2018 Nov 21;13(11):e0206803. doi: 10.1371/journal.pone.0206803. eCollection 2018. PLoS One. 2018. PMID: 30462667 Free PMC article.
Nonlinear Z-score modeling for improved detection of cognitive abnormality.
Kornak J, Fields J, Kremers W, Farmer S, Heuer HW, Forsberg L, Brushaber D, Rindels A, Dodge H, Weintraub S, Besser L, Appleby B, Bordelon Y, Bove J, Brannelly P, Caso C, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fishman A, Fong J, Foroud T, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant IM, Grossman M, Haley D, Hsiao J, Hsiung R, Huey ED, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Kaufer D, Kerwin D, Knopman D, Kraft R, Kramer J, Kukull W, Lapid M, Litvan I, Ljubenkov P, Lucente D, Lungu C, Mackenzie I, Maldonado M, Manoochehri M, McGinnis S, McKinley E, Mendez M, Miller B, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Roberson ED, Rogalski-Miller E, Sengdy P, Shaw L, Staffaroni AM, Sutherland M, Syrjanen J, Tartaglia C, Tatton N, Taylor J, Toga A, Trojanowski J, Wang P, Wong B, Wszolek Z, Boeve B, Boxer A, Rosen H; ARTFL/LEFFTDS Consortium. Kornak J, et al. Among authors: besser l. Alzheimers Dement (Amst). 2019 Dec 5;11:797-808. doi: 10.1016/j.dadm.2019.08.003. eCollection 2019 Dec. Alzheimers Dement (Amst). 2019. PMID: 31872042 Free PMC article.
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.
Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner TT, Jaunmuktane Z, Galasko D, Santana I, Tienari PJ, Myllykangas L, Oinas M, Cairns NJ, Morris JC, Halliday GM, Van Deerlin VM, Trojanowski JQ, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Brett F, Gan-Or Z, Geiger JT, Moore A, May P, Krüger R, Goldstein DS, Lopez G, Tayebi N, Sidransky E; American Genome Center; Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Shakkottai VG, Perkins M, Newell KL, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim RC, Caraway CA, Monuki ES, Brunetti M, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Flanagan ME, Mao Q, Bigio EH, Rodríguez-Rodríguez E, Infante J, Lage C, González-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black SE, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett MJ, Tilley BS, Gentleman S, Logroscino G, Serrano GE, … See abstract for full author list ➔ Chia R, et al. Among authors: besser lm. Nat Genet. 2021 Mar;53(3):294-303. doi: 10.1038/s41588-021-00785-3. Epub 2021 Feb 15. Nat Genet. 2021. PMID: 33589841 Free PMC article.
Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set.
Alosco ML, Duskin J, Besser LM, Martin B, Chaisson CE, Gunstad J, Kowall NW, McKee AC, Stern RA, Tripodis Y. Alosco ML, et al. Among authors: besser lm. J Alzheimers Dis. 2017;57(3):953-968. doi: 10.3233/JAD-161205. J Alzheimers Dis. 2017. PMID: 28304301 Free PMC article.
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Dewan R, Chia R, Ding J, Hickman RA, Stein TD, Abramzon Y, Ahmed S, Sabir MS, Portley MK, Tucci A, Ibáñez K, Shankaracharya FNU, Keagle P, Rossi G, Caroppo P, Tagliavini F, Waldo ML, Johansson PM, Nilsson CF; American Genome Center (TAGC); FALS Sequencing Consortium; Genomics England Research Consortium; International ALS/FTD Genomics Consortium (iAFGC); International FTD Genetics Consortium (IFGC); International LBD Genomics Consortium (iLBDGC); NYGC ALS Consortium; PROSPECT Consortium; Rowe JB, Benussi L, Binetti G, Ghidoni R, Jabbari E, Viollet C, Glass JD, Singleton AB, Silani V, Ross OA, Ryten M, Torkamani A, Tanaka T, Ferrucci L, Resnick SM, Pickering-Brown S, Brady CB, Kowal N, Hardy JA, Van Deerlin V, Vonsattel JP, Harms MB, Morris HR, Ferrari R, Landers JE, Chiò A, Gibbs JR, Dalgard CL, Scholz SW, Traynor BJ. Dewan R, et al. Neuron. 2021 Feb 3;109(3):448-460.e4. doi: 10.1016/j.neuron.2020.11.005. Epub 2020 Nov 26. Neuron. 2021. PMID: 33242422 Free PMC article.
Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia.
Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Sugarman MA, et al. Among authors: besser lm. Alzheimers Dement. 2019 May;15(5):686-698. doi: 10.1016/j.jalz.2018.12.015. Epub 2019 Mar 7. Alzheimers Dement. 2019. PMID: 30852157 Free PMC article.
Commute time and social capital in the U.S.
Besser LM, Marcus M, Frumkin H. Besser LM, et al. Am J Prev Med. 2008 Mar;34(3):207-11. doi: 10.1016/j.amepre.2007.12.004. Am J Prev Med. 2008. PMID: 18312808
Neighborhood racial/ethnic segregation and cognitive decline in older adults.
Meyer OL, Besser L, Mitsova D, Booker M, Luu E, Tobias M, Farias ST, Mungas D, DeCarli C, Whitmer RA. Meyer OL, et al. Among authors: besser l. Soc Sci Med. 2021 Sep;284:114226. doi: 10.1016/j.socscimed.2021.114226. Epub 2021 Jul 12. Soc Sci Med. 2021. PMID: 34303293 Free PMC article.
Longitudinal neighbourhood determinants with cognitive health and dementia disparities: protocol of the Multi-Ethnic Study of Atherosclerosis Neighborhoods and Aging prospective cohort study.
Hirsch JA, Michael YL, Moore KA, Melly S, Hughes TM, Hayden K, Luchsinger JA, Jimenez MP, James P, Besser LM, Sánchez B, Diez Roux AV. Hirsch JA, et al. Among authors: besser lm. BMJ Open. 2022 Nov 11;12(11):e066971. doi: 10.1136/bmjopen-2022-066971. BMJ Open. 2022. PMID: 36368762 Free PMC article.
Global rural health disparities in Alzheimer's disease and related dementias: State of the science.
Wiese LAK, Gibson A, Guest MA, Nelson AR, Weaver R, Gupta A, Carmichael O, Lewis JP, Lindauer A, Loi S, Peterson R, Radford K, Rhodus EK, Wong CG, Zuelsdorff M, Saidi LG, Valdivieso-Mora E, Franzen S, Pope CN, Killian TS, Shrestha HL, Heyn PC, Ng TKS, Prusaczyk B, John S, Kulshreshtha A, Sheffler JL, Besser L, Daniel V, Tolea MI, Miller J, Musyimi C, Corkey J, Yank V, Williams CL, Rahemi Z, Park J, Magzamen S, Newton RL Jr, Harrington C, Flatt JD, Arora S, Walter S, Griffin P, Babulal GM. Wiese LAK, et al. Among authors: besser l. Alzheimers Dement. 2023 Sep;19(9):4204-4225. doi: 10.1002/alz.13104. Epub 2023 May 23. Alzheimers Dement. 2023. PMID: 37218539 Free PMC article. Review.
Diabetes mellitus and birth defects.
Correa A, Gilboa SM, Besser LM, Botto LD, Moore CA, Hobbs CA, Cleves MA, Riehle-Colarusso TJ, Waller DK, Reece EA. Correa A, et al. Am J Obstet Gynecol. 2008 Sep;199(3):237.e1-9. doi: 10.1016/j.ajog.2008.06.028. Epub 2008 Jul 31. Am J Obstet Gynecol. 2008. PMID: 18674752 Free PMC article.
Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin protective antigen.
Quinn CP, Semenova VA, Elie CM, Romero-Steiner S, Greene C, Li H, Stamey K, Steward-Clark E, Schmidt DS, Mothershed E, Pruckler J, Schwartz S, Benson RF, Helsel LO, Holder PF, Johnson SE, Kellum M, Messmer T, Thacker WL, Besser L, Plikaytis BD, Taylor TH Jr, Freeman AE, Wallace KJ, Dull P, Sejvar J, Bruce E, Moreno R, Schuchat A, Lingappa JR, Martin SK, Walls J, Bronsdon M, Carlone GM, Bajani-Ari M, Ashford DA, Stephens DS, Perkins BA. Quinn CP, et al. Among authors: besser l. Emerg Infect Dis. 2002 Oct;8(10):1103-10. doi: 10.3201/eid0810.020380. Emerg Infect Dis. 2002. PMID: 12396924 Free PMC article.
Neighborhood socioeconomic status and segregation linked to cognitive decline.
Meyer OL, Besser L, Tobias M, George KM, Gavett B, Farias ST, Bhagat N, Pham ML, Chrisphonte S, Whitmer RA. Meyer OL, et al. Among authors: besser l. Alzheimers Dement (Amst). 2023 Feb 8;15(1):e12401. doi: 10.1002/dad2.12401. eCollection 2023 Jan-Mar. Alzheimers Dement (Amst). 2023. PMID: 36788980 Free PMC article.
Neighborhood greenspace and cognition: The cardiovascular health study.
Godina SL, Rosso AL, Hirsch JA, Besser LM, Lovasi GS, Donovan GH, Garg PK, Platt JM, Fitzpatrick AL, Lopez OL, Carlson MC, Michael YL. Godina SL, et al. Among authors: besser lm. Health Place. 2023 Jan;79:102960. doi: 10.1016/j.healthplace.2022.102960. Epub 2023 Jan 3. Health Place. 2023. PMID: 36603455 Free PMC article.
Investigation of the genetic aetiology of Lewy body diseases with and without dementia.
Wu LY, Real R, Martinez-Carrasco A, Chia R, Lawton MA, Shoai M, Bresner C, Blauwendraat C, Singleton AB, Ryten M; International Lewy Body Dementia Genomics Consortium; Scholz SW, Traynor BJ, Williams NM, Hu MTM, Ben-Shlomo Y, Grosset DG, Hardy J, Morris HR. Wu LY, et al. Brain Commun. 2024 May 31;6(4):fcae190. doi: 10.1093/braincomms/fcae190. eCollection 2024. Brain Commun. 2024. PMID: 38978726 Free PMC article.
Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study.
Besser LM, Lovasi GS, Zambrano JJ, Camacho S, Dhanekula D, Michael YL, Garg P, Hirsch JA, Siscovick D, Hurvitz PM, Biggs ML, Galvin JE, Bartz TM, Longstreth WT. Besser LM, et al. Alzheimers Dement (Amst). 2023 Oct 25;15(4):e12484. doi: 10.1002/dad2.12484. eCollection 2023 Oct-Dec. Alzheimers Dement (Amst). 2023. PMID: 37885920 Free PMC article.
Riding the merry-go-round of racial disparities in ADRD research.
Adkins-Jackson PB, Kraal AZ, Hill-Jarrett TG, George KM, Deters KD, Besser LM, Avila-Rieger JF, Turney I, Manly JJ. Adkins-Jackson PB, et al. Alzheimers Dement. 2023 Oct;19(10):4735-4742. doi: 10.1002/alz.13359. Epub 2023 Jul 3. Alzheimers Dement. 2023. PMID: 37394968 Free PMC article.
The structural and social determinants of Alzheimer's disease related dementias.
Adkins-Jackson PB, George KM, Besser LM, Hyun J, Lamar M, Hill-Jarrett TG, Bubu OM, Flatt JD, Heyn PC, Cicero EC, Zarina Kraal A, Pushpalata Zanwar P, Peterson R, Kim B, Turner RW 2nd, Viswanathan J, Kulick ER, Zuelsdorff M, Stites SD, Arce Rentería M, Tsoy E, Seblova D, Ng TKS, Manly JJ, Babulal G. Adkins-Jackson PB, et al. Alzheimers Dement. 2023 Jul;19(7):3171-3185. doi: 10.1002/alz.13027. Epub 2023 Apr 19. Alzheimers Dement. 2023. PMID: 37074203 Free PMC article. Review.
Happiness, Meaning, and Psychological Richness.
Oishi S, Choi H, Koo M, Galinha I, Ishii K, Komiya A, Luhmann M, Scollon C, Shin JE, Lee H, Suh EM, Vittersø J, Heintzelman SJ, Kushlev K, Westgate EC, Buttrick N, Tucker J, Ebersole CR, Axt J, Gilbert E, Ng BW, Kurtz J, Besser LL. Oishi S, et al. Among authors: besser ll. Affect Sci. 2020 Jun 23;1(2):107-115. doi: 10.1007/s42761-020-00011-z. eCollection 2020 Jun. Affect Sci. 2020. PMID: 36042966 Free PMC article.
Early onset preeclampsia and cerebral palsy: a double hit model?
Mor O, Stavsky M, Yitshak-Sade M, Mastrolia SA, Beer-Weisel R, Rafaeli-Yehudai T, Besser L, Hamou B, Mazor M, Erez O. Mor O, et al. Among authors: besser l. Am J Obstet Gynecol. 2016 Jan;214(1):105.e1-9. doi: 10.1016/j.ajog.2015.08.020. Epub 2015 Aug 15. Am J Obstet Gynecol. 2016. PMID: 26283455
Antenatal diagnosis and treatment of hypothyroid fetal goiter in an euthyroid mother: a case report and review of literature.
Mastrolia SA, Mandola A, Mazor M, Hershkovitz R, Mesner O, Beer-Weisel R, Besser L, Shelef I, Loewenthal N, Golan A, Gruzman I, Erez O. Mastrolia SA, et al. Among authors: besser l. J Matern Fetal Neonatal Med. 2015;28(18):2214-20. doi: 10.3109/14767058.2014.983062. Epub 2014 Dec 8. J Matern Fetal Neonatal Med. 2015. PMID: 25363013 Review.
Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration.
Frederickson CJ, Giblin LJ 3rd, Balaji RV, Masalha R, Frederickson CJ, Zeng Y, Lopez EV, Koh JY, Chorin U, Besser L, Hershfinkel M, Li Y, Thompson RB, Krezel A. Frederickson CJ, et al. Among authors: besser l. J Neurosci Methods. 2006 Jun 30;154(1-2):19-29. doi: 10.1016/j.jneumeth.2005.11.014. Epub 2006 Feb 7. J Neurosci Methods. 2006. PMID: 16460810
A role for ZnT-1 in regulating cellular cation influx.
Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I. Segal D, et al. Among authors: besser l. Biochem Biophys Res Commun. 2004 Oct 29;323(4):1145-50. doi: 10.1016/j.bbrc.2004.08.211. Biochem Biophys Res Commun. 2004. PMID: 15451416
[Therapeutic interventions in solvent abuse].
Wiencke T, Besser L, Thomasius R. Wiencke T, et al. Among authors: besser l. Nervenarzt. 1990 Mar;61(3):186-8. Nervenarzt. 1990. PMID: 2325792 German. No abstract available.