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Page 1
The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases.
Di Mauro R, Cantarella G, Bernardini R, Di Rosa M, Barbagallo I, Distefano A, Longhitano L, Vicario N, Nicolosi D, Lazzarino G, Tibullo D, Gulino ME, Spampinato M, Avola R, Li Volti G. Di Mauro R, et al. Among authors: longhitano l. Int J Mol Sci. 2019 Feb 1;20(3):634. doi: 10.3390/ijms20030634. Int J Mol Sci. 2019. PMID: 30717203 Free PMC article. Review.
Biological properties of Cakile maritima Scop. (Brassicaceae) extracts.
Fuochi V, Barbagallo I, Distefano A, Puglisi F, Palmeri R, Di Rosa M, Giallongo C, Longhitano L, Fontana P, Sferrazzo G, Tiralongo F, Raccuia SA, Ronsisvalle S, Li Volti G, Furneri PM, Tibullo D. Fuochi V, et al. Among authors: longhitano l. Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2280-2292. doi: 10.26355/eurrev_201903_17277. Eur Rev Med Pharmacol Sci. 2019. PMID: 30915777 Free article.
Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells.
Giallongo S, Di Rosa M, Caltabiano R, Longhitano L, Reibaldi M, Distefano A, Lo Re O, Amorini AM, Puzzo L, Salvatorelli L, Palmucci S, Tibullo D, Russo A, Longo A, Lazzarino G, Li Volti G, Vinciguerra M. Giallongo S, et al. Among authors: longhitano l. Aging (Albany NY). 2020 May 12;12(10):9745-9760. doi: 10.18632/aging.103241. Epub 2020 May 12. Aging (Albany NY). 2020. PMID: 32401230 Free PMC article.
Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2.
Longhitano L, Tibullo D, Giallongo C, Lazzarino G, Tartaglia N, Galimberti S, Li Volti G, Palumbo GA, Liso A. Longhitano L, et al. Int J Mol Sci. 2020 May 20;21(10):3622. doi: 10.3390/ijms21103622. Int J Mol Sci. 2020. PMID: 32443911 Free PMC article. Review.
Focus on Osteosclerotic Progression in Primary Myelofibrosis.
Spampinato M, Giallongo C, Romano A, Longhitano L, La Spina E, Avola R, Scandura G, Dulcamare I, Bramanti V, Di Rosa M, Vicario N, Parenti R, Li Volti G, Tibullo D, Palumbo GA. Spampinato M, et al. Among authors: longhitano l. Biomolecules. 2021 Jan 19;11(1):122. doi: 10.3390/biom11010122. Biomolecules. 2021. PMID: 33477816 Free PMC article. Review.
IGFBP-6/sonic hedgehog/TLR4 signalling axis drives bone marrow fibrotic transformation in primary myelofibrosis.
Longhitano L, Tibullo D, Vicario N, Giallongo C, La Spina E, Romano A, Lombardo S, Moretti M, Masia F, Coda ARD, Venuto S, Fontana P, Parenti R, Li Volti G, Di Rosa M, Palumbo GA, Liso A. Longhitano L, et al. Aging (Albany NY). 2021 Dec 14;13(23):25055-25071. doi: 10.18632/aging.203779. Epub 2021 Dec 14. Aging (Albany NY). 2021. PMID: 34905501 Free PMC article.
TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment.
Scandura G, Giallongo C, Puglisi F, Romano A, Parrinello NL, Zuppelli T, Longhitano L, Giallongo S, Di Rosa M, Musumeci G, Motterlini R, Foresti R, Palumbo GA, Li Volti G, Di Raimondo F, Tibullo D. Scandura G, et al. Among authors: longhitano l. Antioxidants (Basel). 2022 Apr 12;11(4):767. doi: 10.3390/antiox11040767. Antioxidants (Basel). 2022. PMID: 35453452 Free PMC article.
The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression.
Torrisi F, Alberghina C, D'Aprile S, Pavone AM, Longhitano L, Giallongo S, Tibullo D, Di Rosa M, Zappalà A, Cammarata FP, Russo G, Ippolito M, Cuttone G, Li Volti G, Vicario N, Parenti R. Torrisi F, et al. Among authors: longhitano l. Biomedicines. 2022 Mar 30;10(4):806. doi: 10.3390/biomedicines10040806. Biomedicines. 2022. PMID: 35453557 Free PMC article. Review.
Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.
Longhitano L, Vicario N, Forte S, Giallongo C, Broggi G, Caltabiano R, Barbagallo GMV, Altieri R, Raciti G, Di Rosa M, Caruso M, Parenti R, Liso A, Busi F, Lolicato M, Mione MC, Li Volti G, Tibullo D. Longhitano L, et al. Cancer Immunol Immunother. 2023 Jan;72(1):1-20. doi: 10.1007/s00262-022-03215-3. Epub 2022 Jun 3. Cancer Immunol Immunother. 2023. PMID: 35654889 Free PMC article.
Correction to: Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.
Longhitano L, Vicario N, Forte S, Giallongo C, Broggi G, Caltabiano R, Barbagallo GMV, Altieri R, Raciti G, Di Rosa M, Caruso M, Parenti R, Liso A, Busi F, Lolicato M, Mione MC, Li Volti G, Tibullo D. Longhitano L, et al. Cancer Immunol Immunother. 2023 Jan;72(1):21. doi: 10.1007/s00262-022-03243-z. Cancer Immunol Immunother. 2023. PMID: 35821528 Free PMC article. No abstract available.
Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models.
Carota G, Distefano A, Spampinato M, Giallongo C, Broggi G, Longhitano L, Palumbo GA, Parenti R, Caltabiano R, Giallongo S, Di Rosa M, Polosa R, Bramanti V, Vicario N, Li Volti G, Tibullo D. Carota G, et al. Among authors: longhitano l. Antioxidants (Basel). 2022 Aug 18;11(8):1596. doi: 10.3390/antiox11081596. Antioxidants (Basel). 2022. PMID: 36009316 Free PMC article.
The Role of Epigenetics in Neuroinflammatory-Driven Diseases.
Giallongo S, Longhitano L, Denaro S, D'Aprile S, Torrisi F, La Spina E, Giallongo C, Mannino G, Lo Furno D, Zappalà A, Giuffrida R, Parenti R, Li Volti G, Tibullo D, Vicario N. Giallongo S, et al. Among authors: longhitano l. Int J Mol Sci. 2022 Dec 2;23(23):15218. doi: 10.3390/ijms232315218. Int J Mol Sci. 2022. PMID: 36499544 Free PMC article. Review.
Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration.
Denaro S, D'Aprile S, Alberghina C, Pavone AM, Torrisi F, Giallongo S, Longhitano L, Mannino G, Lo Furno D, Zappalà A, Giuffrida R, Tibullo D, Li Volti G, Vicario N, Parenti R. Denaro S, et al. Among authors: longhitano l. Front Immunol. 2022 Dec 19;13:1098212. doi: 10.3389/fimmu.2022.1098212. eCollection 2022. Front Immunol. 2022. PMID: 36601122 Free PMC article. Review.
Autoalgometry: An Important Tool for Pressure Pain Threshold Evaluation.
Lorusso L, Salerno M, Sessa F, Nicolosi D, Longhitano L, Loreto C, Carotenuto M, Messina A, Monda V, Villano I, Cibelli G, Valenzano A, Monda M, Murabito P, Mollica MP, Messina G, Viggiano A. Lorusso L, et al. Among authors: longhitano l. J Clin Med. 2018 Sep 12;7(9):273. doi: 10.3390/jcm7090273. J Clin Med. 2018. PMID: 30213091 Free PMC article.
Modafinil and orexin system: interactions and medico-legal considerations.
Salerno M, Villano I, Nicolosi D, Longhitano L, Loreto C, Lovino A, Sessa F, Polito AN, Monda V, Chieffi S, Messina A, Monda M, Zammit C, Tafuri D, Messina G, Carotenuto M. Salerno M, et al. Among authors: longhitano l. Front Biosci (Landmark Ed). 2019 Jan 1;24(3):564-575. doi: 10.2741/4736. Front Biosci (Landmark Ed). 2019. PMID: 30468674 Free article. Review.
Ethanol-Mediated Stress Promotes Autophagic Survival and Aggressiveness of Colon Cancer Cells via Activation of Nrf2/HO-1 Pathway.
Cernigliaro C, D'Anneo A, Carlisi D, Giuliano M, Marino Gammazza A, Barone R, Longhitano L, Cappello F, Emanuele S, Distefano A, Campanella C, Calvaruso G, Lauricella M. Cernigliaro C, et al. Among authors: longhitano l. Cancers (Basel). 2019 Apr 10;11(4):505. doi: 10.3390/cancers11040505. Cancers (Basel). 2019. PMID: 30974805 Free PMC article.
Toxic effects of biodegradable polylactic acid nanoplastics on developing zebrafish (Danio rerio).
Scalia F, Capparucci F, Amico MD, Marino M, Lamparelli EP, Longhitano L, Giallongo S, Falleti R, Rappa F, Iaria C, Marino F, Della Porta G, Marino Gammazza A, Bucchieri F, Santoro A, Cappello F, Szychlinska MA. Scalia F, et al. Among authors: longhitano l. Sci Rep. 2025 Oct 31;15(1):38145. doi: 10.1038/s41598-025-21849-y. Sci Rep. 2025. PMID: 41173947 Free PMC article.
Correction: Longhitano et al. The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress. Antioxidants 2022, 11, 275.
Longhitano L, Forte S, Orlando L, Grasso S, Barbato A, Vicario N, Parenti R, Fontana P, Amorini AM, Lazzarino G, Li Volti G, Di Rosa M, Liso A, Tavazzi B, Lazzarino G, Tibullo D. Longhitano L, et al. Antioxidants (Basel). 2025 Jun 5;14(6):687. doi: 10.3390/antiox14060687. Antioxidants (Basel). 2025. PMID: 40563389 Free PMC article.
Targeted metabolomic evaluation of peripheral blood mononucleated cells from patients with PMM2-CDG.
Mangione R, Cirnigliaro L, Saab MW, Pettinato F, Barbato A, Distefano A, Spina E, Lazzarino G, Volti GL, Longhitano L, Tibullo D, Pittalà A, Giallongo C, Di Pietro V, Tabbi G, Longo SA, Graziani A, Tavazzi B, Amorini AM, Lazzarino G, Barone R. Mangione R, et al. Among authors: longhitano l. Sci Rep. 2025 May 7;15(1):15929. doi: 10.1038/s41598-025-98846-8. Sci Rep. 2025. PMID: 40335571 Free PMC article.
Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment.
D'Aprile S, Denaro S, Torrisi F, Longhitano L, Giallongo S, Giallongo C, Bontempi V, Bucolo C, Drago F, Mione MC, Li Volti G, Potokar M, Jorgačevski J, Zorec R, Tibullo D, Amorini AM, Vicario N, Parenti R. D'Aprile S, et al. Among authors: longhitano l. Cell Death Dis. 2025 Apr 24;16(1):336. doi: 10.1038/s41419-025-07667-0. Cell Death Dis. 2025. PMID: 40274776 Free PMC article.
Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis.
Spampinato M, Giallongo C, Giallongo S, Spina E, Duminuco A, Longhitano L, Caltabiano R, Salvatorelli L, Broggi G, Pricoco EP, Del Fabro V, Dulcamare I, DI Mauro AM, Romano A, Di Raimondo F, Li Volti G, Palumbo GA, Tibullo D. Spampinato M, et al. Among authors: longhitano l. J Transl Med. 2025 Jan 14;23(1):69. doi: 10.1186/s12967-025-06083-4. J Transl Med. 2025. PMID: 39810250 Free PMC article.
Comparative evaluation of cigarette smoke and a heated tobacco product on microglial toxicity, oxidative stress and inflammatory response.
Distefano A, Orlando L, Partsinevelos K, Longhitano L, Emma R, Caruso M, Vicario N, Denaro S, Sun A, Giordano A, Tomasello B, Alanazi AM, Li Volti G, Amorini AM. Distefano A, et al. Among authors: longhitano l. J Transl Med. 2024 Sep 30;22(1):876. doi: 10.1186/s12967-024-05688-5. J Transl Med. 2024. PMID: 39350202 Free PMC article.
Fish Oil Containing Pro-Resolving Mediators Enhances the Antioxidant System and Ameliorates LPS-Induced Inflammation in Human Bronchial Epithelial Cells.
Distefano A, Orlando L, Giallongo S, Tropea E, Spampinato M, Santisi A, Longhitano L, Parisi G, Leonardi S, Russo A, Caruso M, Di Rosa M, Tibullo D, Salamone M, Li Volti G, Barbagallo IA. Distefano A, et al. Among authors: longhitano l. Pharmaceuticals (Basel). 2024 Aug 14;17(8):1066. doi: 10.3390/ph17081066. Pharmaceuticals (Basel). 2024. PMID: 39204170 Free PMC article.
Enhanced Antitumor Activity by the Combination of Dasatinib and Selinexor in Chronic Myeloid Leukemia.
Spampinato M, Zuppelli T, Dulcamare I, Longhitano L, Sambataro D, Santisi A, Alanazi AM, Barbagallo IA, Vicario N, Parenti R, Romano A, Musumeci G, Li Volti G, Palumbo GA, Di Raimondo F, Nicolosi A, Giallongo S, Del Fabro V. Spampinato M, et al. Among authors: longhitano l. Pharmaceuticals (Basel). 2024 Jul 5;17(7):894. doi: 10.3390/ph17070894. Pharmaceuticals (Basel). 2024. PMID: 39065744 Free PMC article.
(+)Alpha-Lipoic Acid Regulates Lipid Metabolism Gene Expression and Lipidic Profile in a Cellular Model of Fatty Acid Overload.
Longhitano L, Tibullo D, Zuppelli T, Ronsisvalle S, La Spina E, Nicolosi A, Antoci M, Sipala FM, Galvano F, Currenti W, Santisi A, Alanazi AM, Zanghì G, Tropea E, Li Volti G, Barbagallo IA. Longhitano L, et al. Front Biosci (Landmark Ed). 2024 Jun 11;29(6):209. doi: 10.31083/j.fbl2906209. Front Biosci (Landmark Ed). 2024. PMID: 38940024 Free article.
Targeted Metabolomics Highlights Dramatic Antioxidant Depletion, Increased Oxidative/Nitrosative Stress and Altered Purine and Pyrimidine Concentrations in Serum of Primary Myelofibrosis Patients.
Mangione R, Giallongo C, Duminuco A, La Spina E, Longhitano L, Giallongo S, Tibullo D, Lazzarino G, Saab MW, Sbriglione A, Palumbo GA, Graziani A, Alanazi AM, Di Pietro V, Tavazzi B, Amorini AM, Lazzarino G. Mangione R, et al. Among authors: longhitano l. Antioxidants (Basel). 2024 Apr 19;13(4):490. doi: 10.3390/antiox13040490. Antioxidants (Basel). 2024. PMID: 38671937 Free PMC article.
Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off-target effect of radiotherapy.
Alberghina C, Torrisi F, D'Aprile S, Longhitano L, Giallongo S, Scandura G, Mannino G, Mele S, Sabini MG, Cammarata FP, Russo G, Abdelhameed AS, Zappalà A, Lo Furno D, Giuffrida R, Li Volti G, Tibullo D, Vicario N, Parenti R. Alberghina C, et al. Among authors: longhitano l. Cell Prolif. 2024 Jun;57(6):e13606. doi: 10.1111/cpr.13606. Epub 2024 Mar 7. Cell Prolif. 2024. PMID: 38454614 Free PMC article.
(+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease.
Longhitano L, Distefano A, Musso N, Bonacci P, Orlando L, Giallongo S, Tibullo D, Denaro S, Lazzarino G, Ferrigno J, Nicolosi A, Alanazi AM, Salomone F, Tropea E, Barbagallo IA, Bramanti V, Li Volti G, Lazzarino G, Torella D, Amorini AM. Longhitano L, et al. J Transl Med. 2024 Jan 20;22(1):82. doi: 10.1186/s12967-024-04880-x. J Transl Med. 2024. PMID: 38245790 Free PMC article.
Correction: Carota et al. Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models. Antioxidants 2022, 11, 1596.
Carota G, Distefano A, Spampinato M, Giallongo C, Broggi G, Longhitano L, Palumbo GA, Parenti R, Caltabiano R, Giallongo S, Di Rosa M, Polosa R, Bramanti V, Vicario N, Li Volti G, Tibullo D. Carota G, et al. Among authors: longhitano l. Antioxidants (Basel). 2023 Dec 12;12(12):2099. doi: 10.3390/antiox12122099. Antioxidants (Basel). 2023. PMID: 38136252 Free PMC article.
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain.
Denaro S, Pasquinucci L, Turnaturi R, Alberghina C, Longhitano L, Giallongo S, Costanzo G, Spoto S, Grasso M, Zappalà A, Li Volti G, Tibullo D, Vicario N, Parenti R, Parenti C. Denaro S, et al. Among authors: longhitano l. Mol Neurobiol. 2024 May;61(5):2672-2685. doi: 10.1007/s12035-023-03717-w. Epub 2023 Nov 3. Mol Neurobiol. 2024. PMID: 37922065 Free PMC article.
(+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis.
Longhitano L, Distefano A, Amorini AM, Orlando L, Giallongo S, Tibullo D, Lazzarino G, Nicolosi A, Alanazi AM, Saoca C, Macaione V, Aguennouz M, Salomone F, Tropea E, Barbagallo IA, Volti GL, Lazzarino G. Longhitano L, et al. Int J Mol Sci. 2023 Sep 23;24(19):14491. doi: 10.3390/ijms241914491. Int J Mol Sci. 2023. PMID: 37833939 Free PMC article.
Carboplatin and paclitaxel plus avelumab compared with carboplatin and paclitaxel in advanced or recurrent endometrial cancer (MITO END-3): a multicentre, open-label, randomised, controlled, phase 2 trial.
Pignata S, Scambia G, Schettino C, Arenare L, Pisano C, Lombardi D, De Giorgi U, Andreetta C, Cinieri S, De Angelis C, Priolo D, Casanova C, Rosati M, Greco F, Zafarana E, Schiavetto I, Mammoliti S, Cecere SC, Salutari V, Scalone S, Farolfi A, Di Napoli M, Lorusso D, Gargiulo P, Califano D, Russo D, Spina A, De Cecio R, Chiodini P, Perrone F; MITO investigators. Pignata S, et al. Lancet Oncol. 2023 Mar;24(3):286-296. doi: 10.1016/S1470-2045(23)00016-5. Epub 2023 Feb 14. Lancet Oncol. 2023. PMID: 37052965 Clinical Trial.
Mesenchymal stromal cells in tumor microenvironment remodeling of BCR-ABL negative myeloproliferative diseases.
La Spina E, Giallongo S, Giallongo C, Vicario N, Duminuco A, Parenti R, Giuffrida R, Longhitano L, Li Volti G, Cambria D, Di Raimondo F, Musumeci G, Romano A, Palumbo GA, Tibullo D. La Spina E, et al. Among authors: longhitano l. Front Oncol. 2023 Feb 23;13:1141610. doi: 10.3389/fonc.2023.1141610. eCollection 2023. Front Oncol. 2023. PMID: 36910610 Free PMC article. Review.
Labeling of VEGFR1D2 through oxime ligation.
De Rosa L, Di Stasi R, Longhitano L, D'Andrea LD. De Rosa L, et al. Among authors: longhitano l. Bioorg Chem. 2019 Oct;91:103160. doi: 10.1016/j.bioorg.2019.103160. Epub 2019 Jul 29. Bioorg Chem. 2019. PMID: 31398600
Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial.
Martinelli E, Cardone C, Troiani T, Normanno N, Pisconti S, Sforza V, Bordonaro AR, Rachiglio AM, Lambiase M, Latiano TP, Modoni G, Cordio S, Giuliani F, Biglietto M, Montesarchio V, Barone C, Tonini G, Cinieri S, Febbraro A, Rizzi D, De Vita F, Orditura M, Colucci G, Maiello E, Ciardiello F, Iaffaioli V, Nasti G, Nappi A, Botti G, Tatangelo F, Chicchinelli N, Montrone M, Sebastio A, Guarino T, Simone G, Graziano P, Chiarazzo C, Maggio G, Longhitano L, Manusia M, Cartenì G, Nappi O, Micheli P, Leo L, Rossi S, Cassano A, Tommaselli E, Giordano G, Sponziello F, Marino A, Rinaldi A, Romito S, Muda AO, Lorusso V, Leo S, Barni S, Grimaldi G, Aieta M. Martinelli E, et al. Among authors: longhitano l. ESMO Open. 2017 Feb 20;1(6):e000086. doi: 10.1136/esmoopen-2016-000086. eCollection 2016. ESMO Open. 2017. PMID: 28848656 Free PMC article.
Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX.
Ciardiello F, Normanno N, Martinelli E, Troiani T, Pisconti S, Cardone C, Nappi A, Bordonaro AR, Rachiglio M, Lambiase M, Latiano TP, Modoni G, Cordio S, Giuliani F, Biglietto M, Montesarchio V, Barone C, Tonini G, Cinieri S, Febbraro A, Rizzi D, De Vita F, Orditura M, Colucci G, Maiello E; CAPRI-GOIM investigators. Ciardiello F, et al. Ann Oncol. 2016 Jun;27(6):1055-1061. doi: 10.1093/annonc/mdw136. Epub 2016 Mar 21. Ann Oncol. 2016. PMID: 27002107 Free article. Clinical Trial.
Adherence to AIOM (Italian Association of Medical Oncology) lung cancer guidelines in Italian clinical practice: Results from the RIGHT-3 (research for the identification of the most effective and highly accepted clinical guidelines for cancer treatment) study.
Barni S, Maiello E, Di Maio M, Ardizzoni A, Cappuzzo F, Maranzano E, Novello S, Bennati C, Ori A, Rizzoli S, Crinò L; RIGHT-3 study group. Barni S, et al. Lung Cancer. 2015 Nov;90(2):234-42. doi: 10.1016/j.lungcan.2015.08.005. Epub 2015 Aug 19. Lung Cancer. 2015. PMID: 26314614 Free article.