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Page 1
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Desikan RS, et al. Among authors: schork aj. PLoS Med. 2017 Mar 21;14(3):e1002258. doi: 10.1371/journal.pmed.1002258. eCollection 2017 Mar. PLoS Med. 2017. PMID: 28323831 Free PMC article.
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.
Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, Rujescu D, Werge T, van de Bunt M, Morris AP, McCarthy MI; International Consortium for Blood Pressure GWAS; Diabetes Genetics Replication and Meta-analysis Consortium; Psychiatric Genomics Consortium Schizophrenia Working Group; Roddey JC, McEvoy LK, Desikan RS, Dale AM. Andreassen OA, et al. Among authors: schork aj. Am J Hum Genet. 2013 Feb 7;92(2):197-209. doi: 10.1016/j.ajhg.2013.01.001. Epub 2013 Jan 31. Am J Hum Genet. 2013. PMID: 23375658 Free PMC article.
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe JR, O'Donovan MC, Furberg H; Tobacco and Genetics Consortium; Bipolar Disorder Psychiatric Genomics Consortium; Schizophrenia Psychiatric Genomics Consortium; Schork NJ, Andreassen OA, Dale AM. Schork AJ, et al. Among authors: schork nj. PLoS Genet. 2013 Apr;9(4):e1003449. doi: 10.1371/journal.pgen.1003449. Epub 2013 Apr 25. PLoS Genet. 2013. PMID: 23637621 Free PMC article.
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.
Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P; Psychiatric Genomics Consortium (PGC); Bipolar Disorder and Schizophrenia Working Groups; Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM. Andreassen OA, et al. Among authors: schork aj. PLoS Genet. 2013 Apr;9(4):e1003455. doi: 10.1371/journal.pgen.1003455. Epub 2013 Apr 25. PLoS Genet. 2013. PMID: 23637625 Free PMC article.
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.
Andreassen OA, McEvoy LK, Thompson WK, Wang Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM; International Consortium for Blood Pressure Genome-Wide Association Studies, Genetic Factors for Osteoporosis Consortium. Andreassen OA, et al. Among authors: schork aj. Hypertension. 2014 Apr;63(4):819-26. doi: 10.1161/HYPERTENSIONAHA.113.02077. Epub 2014 Jan 6. Hypertension. 2014. PMID: 24396023 Free PMC article.
Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.
Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P; Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups; International Multiple Sclerosis Genetics Consortium (IMSGC); McEvoy LK, Desikan RS, Lie BA, Djurovic S, Dale AM. Andreassen OA, et al. Among authors: schork aj. Mol Psychiatry. 2015 Feb;20(2):207-14. doi: 10.1038/mp.2013.195. Epub 2014 Jan 28. Mol Psychiatry. 2015. PMID: 24468824 Free PMC article.
Shared common variants in prostate cancer and blood lipids.
Andreassen OA, Zuber V, Thompson WK, Schork AJ, Bettella F; PRACTICAL Consortium; CRUK GWAS; Djurovic S, Desikan RS, Mills IG, Dale AM. Andreassen OA, et al. Among authors: schork aj. Int J Epidemiol. 2014 Aug;43(4):1205-14. doi: 10.1093/ije/dyu090. Epub 2014 Apr 30. Int J Epidemiol. 2014. PMID: 24786909 Free PMC article.
Common genetic variants influence human subcortical brain structures.
Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala BS, Armstrong NJ, Bernard M, Bohlken MM, Boks MP, Bralten J, Brown AA, Chakravarty MM, Chen Q, Ching CR, Cuellar-Partida G, den Braber A, Giddaluru S, Goldman AL, Grimm O, Guadalupe T, Hass J, Woldehawariat G, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kim S, Klein M, Kraemer B, Lee PH, Olde Loohuis LM, Luciano M, Macare C, Mather KA, Mattheisen M, Milaneschi Y, Nho K, Papmeyer M, Ramasamy A, Risacher SL, Roiz-Santiañez R, Rose EJ, Salami A, Sämann PG, Schmaal L, Schork AJ, Shin J, Strike LT, Teumer A, van Donkelaar MM, van Eijk KR, Walters RK, Westlye LT, Whelan CD, Winkler AM, Zwiers MP, Alhusaini S, Athanasiu L, Ehrlich S, Hakobjan MM, Hartberg CB, Haukvik UK, Heister AJ, Hoehn D, Kasperaviciute D, Liewald DC, Lopez LM, Makkinje RR, Matarin M, Naber MA, McKay DR, Needham M, Nugent AC, Pütz B, Royle NA, Shen L, Sprooten E, Trabzuni D, van der Marel SS, van Hulzen KJ, Walton E, Wolf C, Almasy L, Ames D, Arepalli S, Assareh AA, Bastin ME, Brodaty H, Bulayeva KB, Carless MA, Cichon S, Corvin A, Curran JE, Czisch M, de Zubicaray GI, Dillman A, Du… See abstract for full author list ➔ Hibar DP, et al. Among authors: schork aj. Nature. 2015 Apr 9;520(7546):224-9. doi: 10.1038/nature14101. Epub 2015 Jan 21. Nature. 2015. PMID: 25607358 Free PMC article.
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Heutink P, Singleton AB, Brice A, Wood NW, Hardy J, Martinez M, Choi SH, DeStefano A, Ikram MA, Bis JC, Smith A, Fitzpatrick AL, Launer L, van Duijn C, Seshadri S, Ulstein ID, Aarsland D, Fladby T, Djurovic S, Hyman BT, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen OA, Dale AM; ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators. Desikan RS, et al. Among authors: schork aj. Mol Psychiatry. 2015 Dec;20(12):1588-95. doi: 10.1038/mp.2015.6. Epub 2015 Feb 17. Mol Psychiatry. 2015. PMID: 25687773 Free PMC article.
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.
Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Andreassen OA, et al. Among authors: schork aj. PLoS One. 2015 Apr 8;10(4):e0123057. doi: 10.1371/journal.pone.0123057. eCollection 2015. PLoS One. 2015. PMID: 25853426 Free PMC article.
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM; Inflammation working group, IGAP and DemGene Investigators. Desikan RS, et al. Among authors: schork aj. Circulation. 2015 Jun 9;131(23):2061-2069. doi: 10.1161/CIRCULATIONAHA.115.015489. Epub 2015 Apr 10. Circulation. 2015. PMID: 25862742 Free PMC article.
MicroRNAs enrichment in GWAS of complex human phenotypes.
Goulart LF, Bettella F, Sønderby IE, Schork AJ, Thompson WK, Mattingsdal M, Steen VM, Zuber V, Wang Y, Dale AM; PRACTICAL/ELLIPSE consortium; Andreassen OA, Djurovic S. Goulart LF, et al. Among authors: schork aj. BMC Genomics. 2015 Apr 16;16(1):304. doi: 10.1186/s12864-015-1513-5. BMC Genomics. 2015. PMID: 25884492 Free PMC article.
Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms.
Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM. Andreassen OA, et al. Among authors: schork aj. PLoS One. 2015 May 15;10(5):e0128048. doi: 10.1371/journal.pone.0128048. eCollection 2015. PLoS One. 2015. PMID: 25978331 Free PMC article. No abstract available.
Modeling the 3D geometry of the cortical surface with genetic ancestry.
Fan CC, Bartsch H, Schork AJ, Chen CH, Wang Y, Lo MT, Brown TT, Kuperman JM, Hagler DJ Jr, Schork NJ, Jernigan TL, Dale AM; Pediatric Imaging, Neurocognition, and Genetics Study. Fan CC, et al. Among authors: schork aj, schork nj. Curr Biol. 2015 Aug 3;25(15):1988-92. doi: 10.1016/j.cub.2015.06.006. Epub 2015 Jul 9. Curr Biol. 2015. PMID: 26166778 Free PMC article.
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Schork N, Dale AM; Pediatric Imaging Neurocognition and Genetics Study; Alzheimer's Disease Neuroimaging Initiative. Chen CH, et al. Among authors: schork aj, schork n. Nat Commun. 2015 Jul 20;6:7549. doi: 10.1038/ncomms8549. Nat Commun. 2015. PMID: 26189703 Free PMC article.
Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors.
LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, Wang Y, McEvoy LK, Thompson WK, Schork AJ, Reppe S, Barrett-Connor E, Ligthart S, Dehghan A, Gautvik KM, Nelson CP, Schunkert H, Samani NJ; CARDIoGRAM Consortium; Ridker PM, Chasman DI, Aukrust P, Djurovic S, Frigessi A, Desikan RS, Dale AM, Andreassen OA. LeBlanc M, et al. Among authors: schork aj. Circ Res. 2016 Jan 8;118(1):83-94. doi: 10.1161/CIRCRESAHA.115.306629. Epub 2015 Oct 20. Circ Res. 2016. PMID: 26487741 Free PMC article.
Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate.
Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, Kendler KS, O'Donovan MC, Rujescu D, Werge T, Sklar P; Psychiatric Genomics Consortium (PGC); Bipolar Disorder and Schizophrenia Working Groups; Roddey JC, Chen CH, McEvoy L, Desikan RS, Djurovic S, Dale AM. Andreassen OA, et al. Among authors: schork aj. PLoS Genet. 2015 Nov 5;11(11):e1005544. doi: 10.1371/journal.pgen.1005544. eCollection 2015 Nov. PLoS Genet. 2015. PMID: 26540268 Free PMC article. No abstract available.
Genetic Markers of Human Evolution Are Enriched in Schizophrenia.
Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson WK, Zuber V; Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium; Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA. Srinivasan S, et al. Among authors: schork aj. Biol Psychiatry. 2016 Aug 15;80(4):284-292. doi: 10.1016/j.biopsych.2015.10.009. Epub 2015 Oct 21. Biol Psychiatry. 2016. PMID: 26681495 Free PMC article.
Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS.
Wang Y, Thompson WK, Schork AJ, Holland D, Chen CH, Bettella F, Desikan RS, Li W, Witoelar A, Zuber V, Devor A; Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium; Enhancing Neuro Imaging Genetics through Meta Analysis Consortium; Nöthen MM, Rietschel M, Chen Q, Werge T, Cichon S, Weinberger DR, Djurovic S, O'Donovan M, Visscher PM, Andreassen OA, Dale AM. Wang Y, et al. Among authors: schork aj. PLoS Genet. 2016 Jan 25;12(1):e1005803. doi: 10.1371/journal.pgen.1005803. eCollection 2016 Jan. PLoS Genet. 2016. PMID: 26808560 Free PMC article.
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Shugart YY, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; ENIGMA Consortium; O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Franke B, et al. Nat Neurosci. 2016 Mar;19(3):420-431. doi: 10.1038/nn.4228. Epub 2016 Feb 1. Nat Neurosci. 2016. PMID: 26854805 Free PMC article.
Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics.
Holland D, Wang Y, Thompson WK, Schork A, Chen CH, Lo MT, Witoelar A; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Enhancing Neuro Imaging Genetics through Meta Analysis Consortium; Werge T, O'Donovan M, Andreassen OA, Dale AM. Holland D, et al. Front Genet. 2016 Feb 16;7:15. doi: 10.3389/fgene.2016.00015. eCollection 2016. Front Genet. 2016. PMID: 26909100 Free PMC article.
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.
Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS; Alzheimer’s Disease Neuroimaging Initiative. Yokoyama JS, et al. Among authors: schork aj. JAMA Neurol. 2016 Jun 1;73(6):691-7. doi: 10.1001/jamaneurol.2016.0150. JAMA Neurol. 2016. PMID: 27088644 Free PMC article.
Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment.
Le Hellard S, Wang Y, Witoelar A, Zuber V, Bettella F, Hugdahl K, Espeseth T, Steen VM, Melle I, Desikan R, Schork AJ, Thompson WK, Dale AM, Djurovic S, Andreassen OA; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Le Hellard S, et al. Among authors: schork aj. Schizophr Bull. 2017 May 1;43(3):654-664. doi: 10.1093/schbul/sbw085. Schizophr Bull. 2017. PMID: 27338279 Free PMC article.
Conservation of Distinct Genetically-Mediated Human Cortical Pattern.
Peng Q, Schork A, Bartsch H, Lo MT, Panizzon MS; Pediatric Imaging, Neurocognition and Genetics Study; Alzheimer’s Disease Neuroimaging Initiative; Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Dale AM, Schork NJ, Chen CH. Peng Q, et al. PLoS Genet. 2016 Jul 26;12(7):e1006143. doi: 10.1371/journal.pgen.1006143. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27459196 Free PMC article.
Pleiotropic Analysis of Lung Cancer and Blood Triglycerides.
Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT. Zuber V, et al. Among authors: schork aj. J Natl Cancer Inst. 2016 Aug 26;108(12):djw167. doi: 10.1093/jnci/djw167. Print 2016 Dec. J Natl Cancer Inst. 2016. PMID: 27565901 Free PMC article.
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Rajan KB, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Sämann PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, … See abstract for full author list ➔ Adams HH, et al. Among authors: schork aj. Nat Neurosci. 2016 Dec;19(12):1569-1582. doi: 10.1038/nn.4398. Epub 2016 Oct 3. Nat Neurosci. 2016. PMID: 27694991 Free PMC article.
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB; International FTD-Genomics Consortium (IFGC),; International Parkinson's Disease Genomics Consortium (IPDGC),; International Genomics of Alzheimer's Project (IGAP),; Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS. Ferrari R, et al. Among authors: schork aj. J Neurol Neurosurg Psychiatry. 2017 Feb;88(2):152-164. doi: 10.1136/jnnp-2016-314411. Epub 2016 Nov 29. J Neurol Neurosurg Psychiatry. 2017. PMID: 27899424 Free PMC article.
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.
Lo MT, Hinds DA, Tung JY, Franz C, Fan CC, Wang Y, Smeland OB, Schork A, Holland D, Kauppi K, Sanyal N, Escott-Price V, Smith DJ, O'Donovan M, Stefansson H, Bjornsdottir G, Thorgeirsson TE, Stefansson K, McEvoy LK, Dale AM, Andreassen OA, Chen CH. Lo MT, et al. Nat Genet. 2017 Jan;49(1):152-156. doi: 10.1038/ng.3736. Epub 2016 Dec 5. Nat Genet. 2017. PMID: 27918536 Free PMC article.
Probing the Association between Early Evolutionary Markers and Schizophrenia.
Srinivasan S, Bettella F, Hassani S, Wang Y, Witoelar A, Schork AJ, Thompson WK, Collier DA, Desikan RS, Melle I, Dale AM, Djurovic S, Andreassen OA. Srinivasan S, et al. Among authors: schork aj. PLoS One. 2017 Jan 12;12(1):e0169227. doi: 10.1371/journal.pone.0169227. eCollection 2017. PLoS One. 2017. PMID: 28081145 Free PMC article.
Novel genetic loci associated with hippocampal volume.
Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R… See abstract for full author list ➔ Hibar DP, et al. Among authors: schork aj. Nat Commun. 2017 Jan 18;8:13624. doi: 10.1038/ncomms13624. Nat Commun. 2017. PMID: 28098162 Free PMC article.
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.
Devor A, Andreassen OA, Wang Y, Mäki-Marttunen T, Smeland OB, Fan CC, Schork AJ, Holland D, Thompson WK, Witoelar A, Chen CH, Desikan RS, McEvoy LK, Djurovic S, Greengard P, Svenningsson P, Einevoll GT, Dale AM. Devor A, et al. Among authors: schork aj. Mol Psychiatry. 2017 Jun;22(6):792-801. doi: 10.1038/mp.2017.33. Epub 2017 Mar 28. Mol Psychiatry. 2017. PMID: 28348379 Free PMC article. Review.
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, Buring JE, Zhang F, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, MacGregor S, Martin NG, Becker CM, Adachi S, Yoshihara K, Enomoto T, Takahashi A, Kamatani Y, Matsuda K, Kubo M, Thorleifsson G, Geirsson RT, Thorsteinsdottir U, Wallace LM; iPSYCH-SSI-Broad Group; Yang J, Velez Edwards DR, Nyegaard M, Low SK, Zondervan KT, Missmer SA, D'Hooghe T, Montgomery GW, Chasman DI, Stefansson K, Tung JY, Nyholt DR. Sapkota Y, et al. Among authors: schork aj. Nat Commun. 2017 May 24;8:15539. doi: 10.1038/ncomms15539. Nat Commun. 2017. PMID: 28537267 Free PMC article.
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG, Djurovic S, Schork AJ, Bettella F, Ellinghaus D, Franke A, Lie BA, McEvoy LK, Karlsen TH, Lesage S, Morris HR, Brice A, Wood NW, Heutink P, Hardy J, Singleton AB, Dale AM, Gasser T, Andreassen OA, Sharma M; International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators. Witoelar A, et al. Among authors: schork aj. JAMA Neurol. 2017 Jul 1;74(7):780-792. doi: 10.1001/jamaneurol.2017.0469. JAMA Neurol. 2017. PMID: 28586827 Free PMC article.
Identification of shared genetic variants between schizophrenia and lung cancer.
Zuber V, Jönsson EG, Frei O, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Smeland OB, Dieset I, Fanous AH, Desikan RS, Küry S, Bézieau S, Dale AM, Mills IG, Andreassen OA. Zuber V, et al. Among authors: schork aj. Sci Rep. 2018 Jan 12;8(1):674. doi: 10.1038/s41598-017-16481-4. Sci Rep. 2018. PMID: 29330379 Free PMC article.
Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment.
Shadrin AA, Smeland OB, Zayats T, Schork AJ, Frei O, Bettella F, Witoelar A, Li W, Eriksen JA, Krull F, Djurovic S, Faraone SV, Reichborn-Kjennerud T, Thompson WK, Johansson S, Haavik J, Dale AM, Wang Y, Andreassen OA. Shadrin AA, et al. Among authors: schork aj. J Am Acad Child Adolesc Psychiatry. 2018 Feb;57(2):86-95. doi: 10.1016/j.jaac.2017.11.013. Epub 2017 Nov 26. J Am Acad Child Adolesc Psychiatry. 2018. PMID: 29413154 Free PMC article.
Beyond heritability: improving discoverability in imaging genetics.
Fan CC, Smeland OB, Schork AJ, Chen CH, Holland D, Lo MT, Sundar VS, Frei O, Jernigan TL, Andreassen OA, Dale AM. Fan CC, et al. Among authors: schork aj. Hum Mol Genet. 2018 May 1;27(R1):R22-R28. doi: 10.1093/hmg/ddy082. Hum Mol Genet. 2018. PMID: 29522091 Free PMC article. Review.
A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia.
Li W, Fan CC, Mäki-Marttunen T, Thompson WK, Schork AJ, Bettella F; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Djurovic S, Dale AM, Andreassen OA, Wang Y. Li W, et al. Among authors: schork aj. Am J Med Genet B Neuropsychiatr Genet. 2018 Jun;177(4):454-467. doi: 10.1002/ajmg.b.32634. Epub 2018 Apr 28. Am J Med Genet B Neuropsychiatr Genet. 2018. PMID: 29704319 Free PMC article.
Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: a proof of concept for multivariate endophenotypes.
Fan CC, Schork AJ, Brown TT, Spencer BE, Akshoomoff N, Chen CH, Kuperman JM, Hagler DJ Jr, Steen VM, Le Hellard S, Håberg AK, Espeseth T, Andreassen OA, Dale AM, Jernigan TL, Halgren E; Pediatric Imaging, Neurocognition and Genetics Study, Alzheimer’s Disease Neuroimaging Initiative. Fan CC, et al. Among authors: schork aj. Transl Psychiatry. 2018 Jun 8;8(1):114. doi: 10.1038/s41398-018-0166-y. Transl Psychiatry. 2018. PMID: 29884845 Free PMC article.
Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.
Erlangsen A, Appadurai V, Wang Y, Turecki G, Mors O, Werge T, Mortensen PB, Starnawska A, Børglum AD, Schork A, Nudel R, Bækvad-Hansen M, Bybjerg-Grauholm J, Hougaard DM, Thompson WK, Nordentoft M, Agerbo E. Erlangsen A, et al. Mol Psychiatry. 2020 Oct;25(10):2410-2421. doi: 10.1038/s41380-018-0218-y. Epub 2018 Aug 16. Mol Psychiatry. 2020. PMID: 30116032 Free PMC article.
Enrichment of genetic markers of recent human evolution in educational and cognitive traits.
Srinivasan S, Bettella F, Frei O, Hill WD, Wang Y, Witoelar A, Schork AJ, Thompson WK, Davies G, Desikan RS, Deary IJ, Melle I, Ueland T, Dale AM, Djurovic S, Smeland OB, Andreassen OA. Srinivasan S, et al. Among authors: schork aj. Sci Rep. 2018 Aug 22;8(1):12585. doi: 10.1038/s41598-018-30387-9. Sci Rep. 2018. PMID: 30135563 Free PMC article.
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.
Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn N, Blangero J, Boomsma DI, Bralten J, Brattbak HR, Brodaty H, Brouwer RM, Bülow R, Calhoun V, Caspers S, Cavalleri G, Chen CH, Cichon S, Ciufolini S, Corvin A, Crespo-Facorro B, Curran JE, Dale AM, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Delanty N, den Braber A, Desrivières S, Donohoe G, Draganski B, Ehrlich S, Espeseth T, Fisher SE, Franke B, Frouin V, Fukunaga M, Gareau T, Glahn DC, Grabe H, Groenewold NA, Haavik J, Håberg A, Hashimoto R, Hehir-Kwa JY, Heinz A, Hillegers MHJ, Hoffmann P, Holleran L, Hottenga JJ, Hulshoff HE, Ikeda M, Jahanshad N, Jernigan T, Jockwitz C, Johansson S, Jonsdottir GA, Jönsson EG, Kahn R, Kaufmann T, Kelly S, Kikuchi M, Knowles EEM, Kolskår KK, Kwok JB, Hellard SL, Leu C, Liu J, Lundervold AJ, Lundervold A, Martin NG, Mather K, Mathias SR, McCormack M, McMahon KL, McRae A, Milaneschi Y, Moreau C, Morris D, Mothersill D, Mühleisen TW, Murray R, Nordvik JE, Nyberg L, Olde Loohuis LM, Ophoff R, Paus T, Pausova Z, Penninx B, Peralta JM, Pike B, Prieto C, Pudas S, Quinlan E, Quintana DS, Re… See abstract for full author list ➔ Sønderby IE, et al. Among authors: schork aj. Mol Psychiatry. 2020 Mar;25(3):584-602. doi: 10.1038/s41380-018-0118-1. Epub 2018 Oct 3. Mol Psychiatry. 2020. PMID: 30283035 Free PMC article.
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.
Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn N, Blangero J, Boomsma DI, Bralten J, Brattbak HR, Brodaty H, Brouwer RM, Bülow R, Calhoun V, Caspers S, Cavalleri G, Chen CH, Cichon S, Ciufolini S, Corvin A, Crespo-Facorro B, Curran JE, Dale AM, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Delanty N, den Braber A, Desrivières S, Donohoe G, Draganski B, Ehrlich S, Espeseth T, Fisher SE, Franke B, Frouin V, Fukunaga M, Gareau T, Glahn DC, Grabe H, Groenewold NA, Haavik J, Håberg A, Hashimoto R, Hehir-Kwa JY, Heinz A, Hillegers MHJ, Hoffmann P, Holleran L, Hottenga JJ, Hulshoff HE, Ikeda M, Jahanshad N, Jernigan T, Jockwitz C, Johansson S, Jonsdottir GA, Jönsson EG, Kahn R, Kaufmann T, Kelly S, Kikuchi M, Knowles EEM, Kolskår KK, Kwok JB, Hellard SL, Leu C, Liu J, Lundervold AJ, Lundervold A, Martin NG, Mather K, Mathias SR, McCormack M, McMahon KL, McRae A, Milaneschi Y, Moreau C, Morris D, Mothersill D, Mühleisen TW, Murray R, Nordvik JE, Nyberg L, Olde Loohuis LM, Ophoff R, Paus T, Pausova Z, Penninx B, Peralta JM, Pike B, Prieto C, Pudas S, Quinlan E, Quintana DS, Re… See abstract for full author list ➔ Sønderby IE, et al. Among authors: schork aj. Mol Psychiatry. 2020 Mar;25(3):692-695. doi: 10.1038/s41380-019-0358-8. Mol Psychiatry. 2020. PMID: 30705424 Free PMC article.
Genetic architecture of subcortical brain structures in 38,851 individuals.
Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, Luciano M, Hofer E, Teumer A, van der Lee SJ, Yang J, Yanek LR, Lee TV, Li S, Hu Y, Koh JY, Eicher JD, Desrivières S, Arias-Vasquez A, Chauhan G, Athanasiu L, Rentería ME, Kim S, Hoehn D, Armstrong NJ, Chen Q, Holmes AJ, den Braber A, Kloszewska I, Andersson M, Espeseth T, Grimm O, Abramovic L, Alhusaini S, Milaneschi Y, Papmeyer M, Axelsson T, Ehrlich S, Roiz-Santiañez R, Kraemer B, Håberg AK, Jones HJ, Pike GB, Stein DJ, Stevens A, Bralten J, Vernooij MW, Harris TB, Filippi I, Witte AV, Guadalupe T, Wittfeld K, Mosley TH, Becker JT, Doan NT, Hagenaars SP, Saba Y, Cuellar-Partida G, Amin N, Hilal S, Nho K, Mirza-Schreiber N, Arfanakis K, Becker DM, Ames D, Goldman AL, Lee PH, Boomsma DI, Lovestone S, Giddaluru S, Le Hellard S, Mattheisen M, Bohlken MM, Kasperaviciute D, Schmaal L, Lawrie SM, Agartz I, Walton E, Tordesillas-Gutierrez D, Davies GE, Shin J, Ipser JC, Vinke LN, Hoogman M, Jia T, Burkhardt R, Klein M, Crivello F, Janowitz D, Carmichael O, Haukvik UK, Aribisala BS, Schmidt H, Strike LT, Cheng CY, Risacher SL, Pütz B, Fleisch… See abstract for full author list ➔ Satizabal CL, et al. Among authors: schork aj. Nat Genet. 2019 Nov;51(11):1624-1636. doi: 10.1038/s41588-019-0511-y. Epub 2019 Oct 21. Nat Genet. 2019. PMID: 31636452 Free PMC article.
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition.
Writing Committee for the ENIGMA-CNV Working Group; van der Meer D, Sønderby IE, Kaufmann T, Walters GB, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn NB, Blangero J, Boomsma DI, Brodaty H, Brouwer RM, Bülow R, Cahn W, Calhoun VD, Caspers S, Cavalleri GL, Ching CRK, Cichon S, Ciufolini S, Corvin A, Crespo-Facorro B, Curran JE, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Delanty N, den Braber A, Desrivieres S, Di Forti M, Doherty JL, Donohoe G, Ehrlich S, Eising E, Espeseth T, Fisher SE, Fladby T, Frei O, Frouin V, Fukunaga M, Gareau T, Glahn DC, Grabe HJ, Groenewold NA, Gústafsson Ó, Haavik J, Haberg AK, Hashimoto R, Hehir-Kwa JY, Hibar DP, Hillegers MHJ, Hoffmann P, Holleran L, Hottenga JJ, Hulshoff Pol HE, Ikeda M, Jacquemont S, Jahanshad N, Jockwitz C, Johansson S, Jönsson EG, Kikuchi M, Knowles EEM, Kwok JB, Le Hellard S, Linden DEJ, Liu J, Lundervold A, Lundervold AJ, Martin NG, Mather KA, Mathias SR, McMahon KL, McRae AF, Medland SE, Moberget T, Moreau C, Morris DW, Mühleisen TW, Murray RM, Nordvik JE, Nyberg L, Olde Loohuis LM, Ophoff RA, Owen MJ, Paus T, Pausova Z, Peralta JM, Pike B, Prieto C, Quinlan EB, Reinbold CS,… See abstract for full author list ➔ Writing Committee for the ENIGMA-CNV Working Group, et al. Among authors: schork aj. JAMA Psychiatry. 2020 Apr 1;77(4):420-430. doi: 10.1001/jamapsychiatry.2019.3779. JAMA Psychiatry. 2020. PMID: 31665216 Free PMC article.
A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population.
Nudel R, Wang Y, Appadurai V, Schork AJ, Buil A, Agerbo E, Bybjerg-Grauholm J, Børglum AD, Daly MJ, Mors O, Hougaard DM, Mortensen PB, Werge T, Nordentoft M, Thompson WK, Benros ME. Nudel R, et al. Among authors: schork aj. Transl Psychiatry. 2019 Nov 11;9(1):283. doi: 10.1038/s41398-019-0622-3. Transl Psychiatry. 2019. PMID: 31712607 Free PMC article.
A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness.
Nudel R, Appadurai V, Schork AJ, Buil A, Bybjerg-Grauholm J, Børglum AD, Daly MJ, Mors O, Hougaard DM, Mortensen PB, Werge T, Nordentoft M, Thompson WK, Benros ME. Nudel R, et al. Among authors: schork aj. Hum Genet. 2020 May;139(5):593-604. doi: 10.1007/s00439-020-02140-8. Epub 2020 Mar 9. Hum Genet. 2020. PMID: 32152699 Free PMC article.
Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders - Findings from a Danish population-based study.
Liu X, Nudel R, Thompson WK, Appadurai V, Schork AJ, Buil A, Rasmussen S, Allesøe RL, Werge T, Mors O, Børglum AD, Hougaard DM, Mortensen PB, Nordentoft M, Benros ME. Liu X, et al. Among authors: schork aj. Brain Behav Immun. 2021 Jan;91:10-23. doi: 10.1016/j.bbi.2020.06.014. Epub 2020 Jun 11. Brain Behav Immun. 2021. PMID: 32534018
Hemochromatosis neural archetype reveals iron disruption in motor circuits.
Loughnan R, Ahern J, Boyle M, Jernigan TL, Hagler DJ Jr, Iversen JR, Frei O, Smith DM, Andreassen O, Zaitlen N, Sugrue L, Thompson WK, Dale A, Schork AJ, Fan CC. Loughnan R, et al. Among authors: schork aj. Sci Adv. 2024 Nov 22;10(47):eadp4431. doi: 10.1126/sciadv.adp4431. Epub 2024 Nov 22. Sci Adv. 2024. PMID: 39576859 Free PMC article.
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S, Winkelmann J, Mitrovic M, Braun F, Ponsioen CY, Croucher PJ, Sterneck M, Teufel A, Mason AL, Saarela J, Leppa V, Dorfman R, Alvaro D, Floreani A, Onengut-Gumuscu S, Rich SS, Thompson WK, Schork AJ, Næss S, Thomsen I, Mayr G, König IR, Hveem K, Cleynen I, Gutierrez-Achury J, Ricaño-Ponce I, van Heel D, Björnsson E, Sandford RN, Durie PR, Melum E, Vatn MH, Silverberg MS, Duerr RH, Padyukov L, Brand S, Sans M, Annese V, Achkar JP, Boberg KM, Marschall HU, Chazouillères O, Bowlus CL, Wijmenga C, Schrumpf E, Vermeire S, Albrecht M; UK-PSCSC Consortium; Rioux JD, Alexander G, Bergquist A, Cho J, Schreiber S, Manns MP, Färkkilä M, Dale AM, Chapman RW, Lazaridis KN; International PSC Study Group; Franke A, Anderson CA, Karlsen TH; International IBD Genetics Consortium. Liu JZ, et al. Among authors: schork aj. Nat Genet. 2013 Jun;45(6):670-5. doi: 10.1038/ng.2616. Epub 2013 Apr 21. Nat Genet. 2013. PMID: 23603763 Free PMC article.
Exploring Comorbidity Within Mental Disorders Among a Danish National Population.
Plana-Ripoll O, Pedersen CB, Holtz Y, Benros ME, Dalsgaard S, de Jonge P, Fan CC, Degenhardt L, Ganna A, Greve AN, Gunn J, Iburg KM, Kessing LV, Lee BK, Lim CCW, Mors O, Nordentoft M, Prior A, Roest AM, Saha S, Schork A, Scott JG, Scott KM, Stedman T, Sørensen HJ, Werge T, Whiteford HA, Laursen TM, Agerbo E, Kessler RC, Mortensen PB, McGrath JJ. Plana-Ripoll O, et al. JAMA Psychiatry. 2019 Mar 1;76(3):259-270. doi: 10.1001/jamapsychiatry.2018.3658. JAMA Psychiatry. 2019. PMID: 30649197 Free PMC article.
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment.
Schork AJ, Won H, Appadurai V, Nudel R, Gandal M, Delaneau O, Revsbech Christiansen M, Hougaard DM, Bækved-Hansen M, Bybjerg-Grauholm J, Giørtz Pedersen M, Agerbo E, Bøcker Pedersen C, Neale BM, Daly MJ, Wray NR, Nordentoft M, Mors O, Børglum AD, Bo Mortensen P, Buil A, Thompson WK, Geschwind DH, Werge T. Schork AJ, et al. Nat Neurosci. 2019 Mar;22(3):353-361. doi: 10.1038/s41593-018-0320-0. Epub 2019 Jan 28. Nat Neurosci. 2019. PMID: 30692689 Free PMC article.
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, Juodakis J, Mahajan A, Bradfield JP, Lin FTJ, Vogelezang S, Bustamante M, Ahluwalia TS, Pitkänen N, Wang CA, Bacelis J, Borges MC, Zhang G, Bedell BA, Rossi RM, Skogstrand K, Peng S, Thompson WK, Appadurai V, Lawlor DA, Kalliala I, Power C, McCarthy MI, Boyd HA, Marazita ML, Hakonarson H, Hayes MG, Scholtens DM, Rivadeneira F, Jaddoe VWV, Vinding RK, Bisgaard H, Knight BA, Pahkala K, Raitakari O, Helgeland Ø, Johansson S, Njølstad PR, Fadista J, Schork AJ, Nudel R, Miller DE, Chen X, Weirauch MT, Mortensen PB, Børglum AD, Nordentoft M, Mors O, Hao K, Ryckman KK, Hougaard DM, Kottyan LC, Pennell CE, Lyytikainen LP, Bønnelykke K, Vrijheid M, Felix JF, Lowe WL Jr, Grant SFA, Hyppönen E, Jacobsson B, Jarvelin MR, Muglia LJ, Murray JC, Freathy RM, Werge TM, Melbye M, Buil A, Feenstra B. Liu X, et al. Among authors: schork aj. Nat Commun. 2019 Sep 2;10(1):3927. doi: 10.1038/s41467-019-11881-8. Nat Commun. 2019. PMID: 31477735 Free PMC article.
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.
Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C; Autism Sequencing Consortium; iPSYCH-Broad Consortium; Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JD. Satterstrom FK, et al. Cell. 2020 Feb 6;180(3):568-584.e23. doi: 10.1016/j.cell.2019.12.036. Epub 2020 Jan 23. Cell. 2020. PMID: 31981491 Free PMC article.
Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status.
Agerbo E, Trabjerg BB, Børglum AD, Schork AJ, Vilhjálmsson BJ, Pedersen CB, Hakulinen C, Albiñana C, Hougaard DM, Grove J, McGrath JJ, Bybjerg-Grauholm J, Mors O, Plana-Ripoll O, Werge T, Wray NR, Mortensen PB, Musliner KL. Agerbo E, et al. Among authors: schork aj. JAMA Psychiatry. 2021 Apr 1;78(4):387-397. doi: 10.1001/jamapsychiatry.2020.4172. JAMA Psychiatry. 2021. PMID: 33439215 Free PMC article.
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans.
Sønderby IE, van der Meer D, Moreau C, Kaufmann T, Walters GB, Ellegaard M, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn NB, Blangero J, Boomsma DI, Brodaty H, Brouwer RM, Bülow R, Bøen R, Cahn W, Calhoun VD, Caspers S, Ching CRK, Cichon S, Ciufolini S, Crespo-Facorro B, Curran JE, Dale AM, Dalvie S, Dazzan P, de Geus EJC, de Zubicaray GI, de Zwarte SMC, Desrivieres S, Doherty JL, Donohoe G, Draganski B, Ehrlich S, Eising E, Espeseth T, Fejgin K, Fisher SE, Fladby T, Frei O, Frouin V, Fukunaga M, Gareau T, Ge T, Glahn DC, Grabe HJ, Groenewold NA, Gústafsson Ó, Haavik J, Haberg AK, Hall J, Hashimoto R, Hehir-Kwa JY, Hibar DP, Hillegers MHJ, Hoffmann P, Holleran L, Holmes AJ, Homuth G, Hottenga JJ, Hulshoff Pol HE, Ikeda M, Jahanshad N, Jockwitz C, Johansson S, Jönsson EG, Jørgensen NR, Kikuchi M, Knowles EEM, Kumar K, Le Hellard S, Leu C, Linden DEJ, Liu J, Lundervold A, Lundervold AJ, Maillard AM, Martin NG, Martin-Brevet S, Mather KA, Mathias SR, McMahon KL, McRae AF, Medland SE, Meyer-Lindenberg A, Moberget T, Modenato C, Sánchez JM, Morris DW, Mühleisen TW, Murray RM, Nielsen J, Nordvik JE, Nyberg L, Loohuis LMO, Ophoff RA, Owen MJ, Paus T, Pa… See abstract for full author list ➔ Sønderby IE, et al. Among authors: schork aj. Transl Psychiatry. 2021 Mar 22;11(1):182. doi: 10.1038/s41398-021-01213-0. Transl Psychiatry. 2021. PMID: 33753722 Free PMC article.
Corrigendum to "Genetic factors underlying the bidirectional relationship between autoimmune and mental disorders - Findings from a Danish population-based study" [Brain Behav. Immun. 91 (2021) 10-23].
Liu X, Nudel R, Thompson WK, Appadurai V, Schork AJ, Buil A, Rasmussen S, Allesøe RL, Werge T, Mors O, Børglum AD, Hougaard DM, Mortensen PB, Nordentoft M, Benros ME. Liu X, et al. Among authors: schork aj. Brain Behav Immun. 2021 Aug;96:307-308. doi: 10.1016/j.bbi.2021.05.019. Epub 2021 May 27. Brain Behav Immun. 2021. PMID: 34052110 No abstract available.
Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.
Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LSJ, van Hulzen KJE, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AMH, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Rüther M, Ambrosino S, Doyle AE, Høvik MF, Dramsdahl M, Tamm L, van Erp TGM, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B. Hoogman M, et al. Among authors: schork a. Lancet Psychiatry. 2017 Apr;4(4):310-319. doi: 10.1016/S2215-0366(17)30049-4. Epub 2017 Feb 16. Lancet Psychiatry. 2017. PMID: 28219628 Free PMC article.
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Sapkota Y, Vivo I, Steinthorsdottir V, Fassbender A, Bowdler L, Buring JE, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, Thorleifsson G, Wallace LM; iPSYCH-SSI-Broad Group; Kraft P, Morris AP, Nyholt DR, Edwards DRV, Nyegaard M, D'Hooghe T, Chasman DI, Stefansson K, Missmer SA, Montgomery GW. Sapkota Y, et al. Among authors: schork aj. Sci Rep. 2017 Sep 12;7(1):11380. doi: 10.1038/s41598-017-10440-9. Sci Rep. 2017. PMID: 28900119 Free PMC article.
Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD.
Brikell I, Wimberley T, Albiñana C, Pedersen EM, Vilhjálmsson BJ, Agerbo E, Demontis D, Børglum AD, Schork AJ, LaBianca S, Werge T, Mors O, Hougaard DM, Thapar A, Mortensen PB, Dalsgaard S. Brikell I, et al. Among authors: schork aj. Am J Psychiatry. 2021 Sep 1;178(9):854-864. doi: 10.1176/appi.ajp.2020.20121686. Epub 2021 Jun 22. Am J Psychiatry. 2021. PMID: 34154395 Free PMC article.
Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder.
LaBianca S, Brikell I, Helenius D, Loughnan R, Mefford J, Palmer CE, Walker R, Gådin JR, Krebs M, Appadurai V, Vaez M, Agerbo E, Pedersen MG, Børglum AD, Hougaard DM, Mors O, Nordentoft M, Mortensen PB, Kendler KS, Jernigan TL, Geschwind DH, Ingason A, Dahl AW, Zaitlen N, Dalsgaard S, Werge TM, Schork AJ. LaBianca S, et al. Among authors: schork aj. Nat Genet. 2024 Feb;56(2):234-244. doi: 10.1038/s41588-023-01593-7. Epub 2023 Nov 30. Nat Genet. 2024. PMID: 38036780 Free PMC article.
Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants.
Vaez M, Montalbano S, Calle Sánchez X, Georgii Hellberg KL, Dehkordi SR, Krebs MD, Meijsen J, Shorter J, Bybjerg-Grauholm J, Mortensen PB, Børglum AD, Hougaard DM, Nordentoft M, Geschwind DH, Buil A, Schork AJ, Helenius D, Raznahan A, Thompson WK, Werge T, Ingason A; iPSYCH Investigators. Vaez M, et al. Among authors: schork aj. JAMA Psychiatry. 2024 Oct 1;81(10):957-966. doi: 10.1001/jamapsychiatry.2024.1453. JAMA Psychiatry. 2024. PMID: 38922630 Free PMC article.
Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome.
Friese RS, Ye C, Nievergelt CM, Schork AJ, Mahapatra NR, Rao F, Napolitan PS, Waalen J, Ehret GB, Munroe PB, Schmid-Schönbein GW, Eskin E, O'Connor DT. Friese RS, et al. Among authors: schork aj. Circ Cardiovasc Genet. 2012 Aug 1;5(4):430-40. doi: 10.1161/CIRCGENETICS.111.962415. Epub 2012 Jun 5. Circ Cardiovasc Genet. 2012. PMID: 22670052 Free PMC article.
Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.
Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT. Zhang K, et al. Among authors: schork aj, schork nj. J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89. doi: 10.1016/j.jacc.2012.06.042. Epub 2012 Sep 26. J Am Coll Cardiol. 2012. PMID: 23021333 Free PMC article.
Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs.
Hightower CM, Zhang K, Miramontes-González JP, Rao F, Wei Z, Schork AJ, Nievergelt CM, Biswas N, Mahata M, Elkelis N, Taupenot L, Stridsberg M, Ziegler MG, O'Connor DT. Hightower CM, et al. Among authors: schork aj. J Neurochem. 2013 Dec;127(6):750-61. doi: 10.1111/jnc.12346. Epub 2013 Jul 19. J Neurochem. 2013. PMID: 23786442 Free PMC article.
Genetic implication of a novel thiamine transporter in human hypertension.
Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB; International Consortium for Blood Pressure Genome-Wide Association Studies; Schork NJ, Eskin E, Nievergelt CM, Saier MH Jr, O'Connor DT. Zhang K, et al. Among authors: schork aj, schork nj. J Am Coll Cardiol. 2014 Apr 22;63(15):1542-55. doi: 10.1016/j.jacc.2014.01.007. Epub 2014 Feb 5. J Am Coll Cardiol. 2014. PMID: 24509276 Free PMC article.
Association between Mental Disorders and Subsequent Medical Conditions.
Momen NC, Plana-Ripoll O, Agerbo E, Benros ME, Børglum AD, Christensen MK, Dalsgaard S, Degenhardt L, de Jonge P, Debost JPG, Fenger-Grøn M, Gunn JM, Iburg KM, Kessing LV, Kessler RC, Laursen TM, Lim CCW, Mors O, Mortensen PB, Musliner KL, Nordentoft M, Pedersen CB, Petersen LV, Ribe AR, Roest AM, Saha S, Schork AJ, Scott KM, Sievert C, Sørensen HJ, Stedman TJ, Vestergaard M, Vilhjalmsson B, Werge T, Weye N, Whiteford HA, Prior A, McGrath JJ. Momen NC, et al. Among authors: schork aj. N Engl J Med. 2020 Apr 30;382(18):1721-1731. doi: 10.1056/NEJMoa1915784. N Engl J Med. 2020. PMID: 32348643 Free PMC article.
Cancer risk in individuals with autism spectrum disorder.
Liu Q, Yin W, Meijsen JJ, Reichenberg A, Gådin JR, Schork AJ, Adami HO, Kolevzon A, Sandin S, Fang F. Liu Q, et al. Among authors: schork aj. Ann Oncol. 2022 Jul;33(7):713-719. doi: 10.1016/j.annonc.2022.04.006. Epub 2022 Apr 14. Ann Oncol. 2022. PMID: 35430370 Free article.
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME, Bauer M, Bearden CE, Bergmann O, Binder EB, Blangero J, Bockholt HJ, Bøen E, Bois C, Boomsma DI, Booth T, Bowman IJ, Bralten J, Brouwer RM, Brunner HG, Brohawn DG, Buckner RL, Buitelaar J, Bulayeva K, Bustillo JR, Calhoun VD, Cannon DM, Cantor RM, Carless MA, Caseras X, Cavalleri GL, Chakravarty MM, Chang KD, Ching CR, Christoforou A, Cichon S, Clark VP, Conrod P, Coppola G, Crespo-Facorro B, Curran JE, Czisch M, Deary IJ, de Geus EJ, den Braber A, Delvecchio G, Depondt C, de Haan L, de Zubicaray GI, Dima D, Dimitrova R, Djurovic S, Dong H, Donohoe G, Duggirala R, Dyer TD, Ehrlich S, Ekman CJ, Elvsåshagen T, Emsell L, Erk S, Espeseth T, Fagerness J, Fears S, Fedko I, Fernández G, Fisher SE, Foroud T, Fox PT, Francks C, Frangou S, Frey EM, Frodl T, Frouin V, Garavan H, Giddaluru S, Glahn DC, Godlewska B, Goldstein RZ, Gollub RL, Grabe HJ, Grimm O, Gruber O, Guadalupe T, Gur RE, Gur RC, Göring HH, Ha… See abstract for full author list ➔ Thompson PM, et al. Among authors: schork aj. Brain Imaging Behav. 2014 Jun;8(2):153-82. doi: 10.1007/s11682-013-9269-5. Brain Imaging Behav. 2014. PMID: 24399358 Free PMC article. Review.
Human heart rate: heritability of resting and stress values in twin pairs, and influence of genetic variation in the adrenergic pathway at a microribonucleic acid (microrna) motif in the 3'-UTR of cytochrome b561 [corrected].
Zhang K, Deacon DC, Rao F, Schork AJ, Fung MM, Waalen J, Schork NJ, Nievergelt CM, Chi NC, O'Connor DT. Zhang K, et al. Among authors: schork aj, schork nj. J Am Coll Cardiol. 2014 Feb 4;63(4):358-68. doi: 10.1016/j.jacc.2013.09.025. Epub 2013 Oct 16. J Am Coll Cardiol. 2014. PMID: 24140660 Free PMC article.
Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study.
Rao F, Schork AJ, Maihofer AX, Nievergelt CM, Marcovina SM, Miller ER, Witztum JL, O'Connor DT, Tsimikas S. Rao F, et al. Among authors: schork aj. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1704-11. doi: 10.1161/ATVBAHA.115.305306. Epub 2015 May 7. Arterioscler Thromb Vasc Biol. 2015. PMID: 25953646 Free PMC article.
Identification of novel loci affecting circulating chromogranins and related peptides.
Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT. Benyamin B, et al. Among authors: schork aj, schork nj. Hum Mol Genet. 2017 Jan 1;26(1):233-242. doi: 10.1093/hmg/ddw380. Hum Mol Genet. 2017. PMID: 28011710 Free PMC article.
Genetic risks and clinical rewards.
Schork AJ, Schork MA, Schork NJ. Schork AJ, et al. Among authors: schork nj, schork ma. Nat Genet. 2018 Sep;50(9):1210-1211. doi: 10.1038/s41588-018-0213-x. Nat Genet. 2018. PMID: 30158681 Free PMC article. No abstract available.
Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus.
Kho PF, Mortlock S; Endometrial Cancer Association Consortium; International Endometriosis Genetics Consortium; Rogers PAW, Nyholt DR, Montgomery GW, Spurdle AB, Glubb DM, O'Mara TA. Kho PF, et al. Hum Genet. 2021 Sep;140(9):1353-1365. doi: 10.1007/s00439-021-02312-0. Epub 2021 Jul 15. Hum Genet. 2021. PMID: 34268601
Indirect paths from genetics to education.
Schork AJ, Peterson RE, Dahl A, Cai N, Kendler KS. Schork AJ, et al. Nat Genet. 2022 Apr;54(4):372-373. doi: 10.1038/s41588-021-00999-5. Nat Genet. 2022. PMID: 35361971 No abstract available.
Interplay of ADHD Polygenic Liability With Birth-Related, Somatic, and Psychosocial Factors in ADHD: A Nationwide Study.
Brikell I, Wimberley T, Albiñana C, Vilhjálmsson BJ, Agerbo E, Børglum AD, Demontis D, Schork AJ, LaBianca S, Werge T, Hougaard DM, Nordentoft M, Mors O, Mortensen PB, Petersen LV, Dalsgaard S. Brikell I, et al. Among authors: schork aj. Am J Psychiatry. 2023 Jan 1;180(1):73-88. doi: 10.1176/appi.ajp.21111105. Epub 2022 Sep 7. Am J Psychiatry. 2023. PMID: 36069019
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group; Horvath S, Geschwind DH. Gandal MJ, et al. Among authors: schork aj. Science. 2018 Feb 9;359(6376):693-697. doi: 10.1126/science.aad6469. Science. 2018. PMID: 29439242 Free PMC article.
Human Disease Variation in the Light of Population Genomics.
Prohaska A, Racimo F, Schork AJ, Sikora M, Stern AJ, Ilardo M, Allentoft ME, Folkersen L, Buil A, Moreno-Mayar JV, Korneliussen T, Geschwind D, Ingason A, Werge T, Nielsen R, Willerslev E. Prohaska A, et al. Among authors: schork aj. Cell. 2019 Mar 21;177(1):115-131. doi: 10.1016/j.cell.2019.01.052. Cell. 2019. PMID: 30901534 Free article. Review.
A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.
Miramontes-Gonzalez JP, Hightower CM, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Nievergelt CM, Baker DG, Ziegler MG, León-Jiménez D, González-Sarmiento R, Ichinose H, O'Connor DT. Miramontes-Gonzalez JP, et al. Among authors: schork aj. Sci Rep. 2019 Mar 25;9(1):5055. doi: 10.1038/s41598-019-41504-7. Sci Rep. 2019. PMID: 30911067 Free PMC article.
Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap.
Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP; CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BROAD Working Group, Steve Horvath; Geschwind DH. Gandal MJ, et al. Among authors: schork aj. Focus (Am Psychiatr Publ). 2019 Jan;17(1):66-72. doi: 10.1176/appi.focus.17103. Epub 2019 Jan 7. Focus (Am Psychiatr Publ). 2019. PMID: 32015716 Free PMC article.
Author Correction: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.
Miramontes-Gonzalez JP, Hightower CM, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Nievergelt CM, Baker DG, Ziegler MG, León-Jiménez D, González-Sarmiento R, Ichinose H, O'Connor DT. Miramontes-Gonzalez JP, et al. Among authors: schork aj. Sci Rep. 2020 Feb 14;10(1):2996. doi: 10.1038/s41598-020-59785-8. Sci Rep. 2020. PMID: 32060363 Free PMC article.
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A. Folkersen L, et al. Nat Metab. 2020 Oct;2(10):1135-1148. doi: 10.1038/s42255-020-00287-2. Epub 2020 Oct 16. Nat Metab. 2020. PMID: 33067605 Free PMC article.
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure.
Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook VY, O'Connor DT. Mbewe-Campbell N, et al. Among authors: schork aj. J Hypertens. 2012 Oct;30(10):1961-9. doi: 10.1097/HJH.0b013e328356b86a. J Hypertens. 2012. PMID: 22871890 Free PMC article.
Accounting for age of onset and family history improves power in genome-wide association studies.
Pedersen EM, Agerbo E, Plana-Ripoll O, Grove J, Dreier JW, Musliner KL, Bækvad-Hansen M, Athanasiadis G, Schork A, Bybjerg-Grauholm J, Hougaard DM, Werge T, Nordentoft M, Mors O, Dalsgaard S, Christensen J, Børglum AD, Mortensen PB, McGrath JJ, Privé F, Vilhjálmsson BJ. Pedersen EM, et al. Am J Hum Genet. 2022 Mar 3;109(3):417-432. doi: 10.1016/j.ajhg.2022.01.009. Epub 2022 Feb 8. Am J Hum Genet. 2022. PMID: 35139346 Free PMC article.
Follow-up of coil occlusion of patent ductus arteriosus.
Shim D, Fedderly RT, Beekman RH 3rd, Ludomirsky A, Young ML, Schork A, Lloyd TR. Shim D, et al. J Am Coll Cardiol. 1996 Jul;28(1):207-11. doi: 10.1016/0735-1097(96)00107-6. J Am Coll Cardiol. 1996. PMID: 8752816 Free article.
The burden of endometriosis on quality of life in Danish women: an analysis of the Danish Blood Donor Study.
Kogelman LJA, Rytter D, Hummelshoj L, Hansen KE, Kirk UB, Beauchamp JL, Bay JT, Bruun MT, Brøns N, Erikstrup C, Aagaard B, Kjerulff BD, Mikkelsen C, Mikkelsen S, Ostrowski SR, Pedersen OB, Sørensen E, Ullum H; DBDS Genomic Consortium; Grosen AK, Hvas CL, Steinthorsdottir V, Stefansson K, Banasik K, Rohde PD, Nielsen HS, Nyegaard M. Kogelman LJA, et al. BMC Med. 2025 Oct 14;23(1):560. doi: 10.1186/s12916-025-04398-z. BMC Med. 2025. PMID: 41088343 Free PMC article.
Genetic risk effects on psychiatric disorders act in sets.
Rietkerk J, Krebs MD, Mefford J, Huang L, Hellberg KG; iPSYCH Study Consortium; Børglum A, Werge T, Kendler KS, Flint J, Schork AJ, Dahl A, Cai N. Rietkerk J, et al. Among authors: schork aj. medRxiv [Preprint]. 2025 Jul 23:2025.07.23.25332043. doi: 10.1101/2025.07.23.25332043. medRxiv. 2025. PMID: 40778121 Free PMC article. Preprint.
Onsite vasovagal reactions with and without loss of consciousness are distinct outcomes with different risk factors.
Mikkelsen C, Sørensen BS, Aagaard B, Hasslund S, Bruun MT, Larsen R, Drechsler LØ, Didriksen M, Schwinn M, Dowsett J; DBDS Genomic Consortium; Sørensen E, Erikstrup C, Pedersen OB, Grarup N, Stefansson K, Hansen MB, Hansen T, Ostrowski SR. Mikkelsen C, et al. Vox Sang. 2025 Sep;120(9):866-873. doi: 10.1111/vox.70072. Epub 2025 Aug 7. Vox Sang. 2025. PMID: 40774814 Free PMC article.
Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults.
Didriksen M, Daníelsdottir H, Bjarnadóttir MD, Overstreet C, Choi KW, Christoffersen LAN, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir EB, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun MT, Ullum H, Sørensen E, Fischer IC, Pietrzak RH, Gelernter J, Campbell-Sills L, Stein MB, Werge T, Pedersen OB, Valdimarsdóttir U, Ostrowski SR, Schork AJ. Didriksen M, et al. Among authors: schork aj. J Mood Anxiety Disord. 2025 Feb 17;10:100112. doi: 10.1016/j.xjmad.2025.100112. eCollection 2025 Jun. J Mood Anxiety Disord. 2025. PMID: 40657597 Free PMC article.
Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort.
Darbani B, Brodersen T, Liljensøe A, Sørensen SB, Olsson-Svendsen JB, Buil A, Kamal A, Schork AJ, Poulsen A, Kjerulff BD, Aagaard B, Lund BØ, Rittig CS, Mikkelsen C, Larsen DM, Westergaard D, Rudbeck-Resdal D, Mikkelsen DH, Randers E, Schiødt FV, Hoffmann HJ, Jørgensen IF, Brandslund I, Brodersen JB, von Stemann JH, Bay JT, Nissen J, Sørensen J, Boldsen JK, Dowsett J, Gladov J, Banasik K, Kaspersen KA, Carlsen K, Dinh KM, Kellermann L, Christoffersen LAN, Quinn LJE, Thørner LW, Larsen L, Aamann L, Andersen MR, Didriksen M, Alexandraki MJ, Thomsen MK, Julsgaard M, Nyegaard M, Schwinn M, Topholm-Bruun M, Leite MN, Halling ML, Pedersen N, Bonderup OK, Rohde PD, Ovesen PD, Dessau RB, Saboori S, Holm-Christensen S, Bank S, Mikkelsen S, Hansen TF, Werge T, Qvist N, Sørensen E, Burisch J, Hetland ML, Glintborg B, Erikstrup C, Brunak S, Ullum H, Ostrowski SR, Pedersen OBV, Andersen V. Darbani B, et al. Among authors: schork aj. Eur J Epidemiol. 2025 Jun;40(6):721-734. doi: 10.1007/s10654-025-01239-4. Epub 2025 Jun 9. Eur J Epidemiol. 2025. PMID: 40488802 Free PMC article.
Nationwide longitudinal study reveals impact of both national restriction levels and genetic risk factors on loneliness during the COVID-19 pandemic.
Quinn L, Didriksen M, Erikstrup C, Aagaard B, Mikkelsen C; DBDS genetic consortium; Ullum H, Nissen J, Bay JT, Dinh KM, Bruun MT, Ostrowski SR, Werge T, Schork AJ, Pedersen OB, Christoffersen LAN. Quinn L, et al. Among authors: schork aj. Sci Rep. 2025 May 20;15(1):17554. doi: 10.1038/s41598-025-02293-4. Sci Rep. 2025. PMID: 40394080 Free PMC article.
Impaired health-related quality of life, and depressive symptoms in a cohort of healthy adults with symptoms of attention deficit/hyperactivity disorder.
Hald A, Pedersen OB, Burgdorf KS, Thørner LW, Mikkelsen C, Christoffersen LAN, Ullum H, Hjalgrim H, Erikstrup C, Bruun MT, Aagaard B, Mikkelsen S, Hansen TF, Werge T, Schork AJ, Ostrowski SR, Didriksen M. Hald A, et al. Among authors: schork aj. Eur Psychiatry. 2025 Mar 3;68(1):e44. doi: 10.1192/j.eurpsy.2025.30. Eur Psychiatry. 2025. PMID: 40026115 Free PMC article.
Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics.
Andersson NW, Wu X, Geller F, Wohlfahrt J, Melbye M, Hviid A, Schwinn M, Mikkelsen C, Dowsett J, Bruun MT, Aagaard B, Ullum H, Erikstrup C, Gudbjartsson DF, Stefánsson K, Ghouse J, Pedersen OB, Sørensen E, Ostrowski SR, Bundgaard H, Lund M, Feenstra B; DBDS Genomic Consortium. Andersson NW, et al. J Am Soc Nephrol. 2025 Jun 1;36(6):1014-1027. doi: 10.1681/ASN.0000000622. Epub 2025 Jan 31. J Am Soc Nephrol. 2025. PMID: 39888683
Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses.
Panagiotaropoulou G, Hellberg KG, Coleman JRI, Seok D, Kalman J; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; iPSYCH Study Consortium; Mitchell PB, Schofield PR, Forstner AJ, Bauer M, Scott LJ, Pato CN, Pato MT, Li QS, Kirov G, Landén M, Jonsson L, Müller-Myhsok B, Smoller JW, Binder EB, Brückl TM, Czamara D, Van der Auwera S, Grabe HJ, Homuth G, Schmidt CO, Potash JB, DePaulo JR, Goes FS, MacKinnon DF, Mondimore FM, Weissman MM, Shi J, Frye MA, Biernacka JM, Reif A, Witt SH, Kahn RR, Boks MM, Owen MJ, Gordon-Smith K, Mitchell BL, Martin NG, Medland SE, Jones L, Knowles JA, Levinson DF, O'Donovan MC, Lewis CM, Breen G, Werge T, Schork AJ, Ophoff RA, Ripke S, Olde Loohuis L. Panagiotaropoulou G, et al. Among authors: schork aj. Br J Psychiatry. 2025 Feb;226(2):79-90. doi: 10.1192/bjp.2024.125. Epub 2025 Jan 14. Br J Psychiatry. 2025. PMID: 39806801 Free PMC article.
Novel loci and biomedical consequences of iron homoeostasis variation.
Allara E, Bell S, Smith R, Keene SJ, Gill D, Gaziano L, Morselli Gysi D, Wang F, Tragante V, Mason A, Karthikeyan S, Lumbers RT, Bonglack E, Ouwehand W, Roberts DJ, Dowsett J, Ostrowski SR, Larsen MH, Ullum H, Pedersen OB, Brunak S, Banasik K, Erikstrup C; DBDS Genomic Consortium; Mitchell J, Fuchsberger C, Pattaro C, Pramstaller PP, Girelli D, Arvas M, Toivonen J, Molnos S, Peters A, Polasek O, Rudan I, Hayward C, McDonnell C, Pirastu N, Wilson JF, van den Hurk K, Quee F, Ferrucci L, Bandinelli S, Tanaka T, Girotto G, Concas MP, Pecori A, Verweij N, van der Harst P, van de Vegte YJ, Kiemeney LA, Sweep FC, Galesloot TE, Sulem P, Gudbjartsson D, Ferkingstad E; FinnGen Consortium; Djousse L, Cho K, Inouye M, Burgess S, Benyamin B, Oexle K, Swinkels D, Stefansson K, Magnusson M, Ganna A, Gaziano M, Ivey K, Danesh J, Pereira A, Wood AM, Butterworth AS, Di Angelantonio E. Allara E, et al. Commun Biol. 2024 Dec 6;7(1):1631. doi: 10.1038/s42003-024-07115-3. Commun Biol. 2024. PMID: 39643614 Free PMC article.
Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression.
Dybdahl Krebs M, Georgii Hellberg KL, Lundberg M, Appadurai V, Ohlsson H, Pedersen E, Steinbach J, Matthews J, Border R, LaBianca S, Calle X, Meijsen JJ; iPSYCH Study Consortium,; Ingason A, Buil A, Vilhjálmsson BJ, Flint J, Bacanu SA, Cai N, Dahl A, Zaitlen N, Werge T, Kendler KS, Schork AJ. Dybdahl Krebs M, et al. Among authors: schork aj. Am J Hum Genet. 2024 Nov 7;111(11):2494-2509. doi: 10.1016/j.ajhg.2024.09.009. Epub 2024 Oct 28. Am J Hum Genet. 2024. PMID: 39471805 Free PMC article.
Evaluating the Joint Effects of Recurrent Copy Number Variants and Polygenic Scores on the Risk of Psychiatric Disorders in the iPSYCH2015 Case-Cohort Sample.
Vaez M, Montalbano S, Waples R, Krebs MD, Hellberg KG, Gådin J, Bybjerg-Grauholm J, Mortensen PB, Børglum AD, Nordentoft M, Geschwind DH, Helenius D, Werge T, Schork AJ, Ingason A. Vaez M, et al. Among authors: schork aj. medRxiv [Preprint]. 2024 Nov 22:2024.09.23.24314234. doi: 10.1101/2024.09.23.24314234. medRxiv. 2024. PMID: 39398991 Free PMC article. Preprint.
Assortative mating across nine psychiatric disorders is consistent and persistent over cultures and generations.
Fan CC, Dehkordi SR, Border R, Shao L, Xu B, Loughnan R, Thompson WK, Hsu LY, Lin MC, Cheng CF, Lai RY, Su MH, Kao WY, Werge T, Wu CS, Schork AJ, Zaitlen N, Demur AB, Wang SH. Fan CC, et al. Among authors: schork aj. medRxiv [Preprint]. 2024 Sep 22:2024.09.19.24314024. doi: 10.1101/2024.09.19.24314024. medRxiv. 2024. Update in: Nat Hum Behav. 2025 Aug 28. doi: 10.1038/s41562-025-02298-z. PMID: 39371142 Free PMC article. Updated. Preprint.
No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study.
Tummoszeit IZ, Olofsson IA, Chalmer MA, Henriksen AP, Aagaard B, Brunak S, Bruun MT, Didriksen M, Erikstrup C, Hjalgrim H, Mikkelsen C, Mikkelsen S, Ostrowski SR, Pedersen OBV, Quinn L, Sørensen E, Ullum H, Olesen J, Banasik K, Hansen TF, Kogelman LJA; DBDS Genomic consortium group. Tummoszeit IZ, et al. Headache. 2025 Jan;65(1):124-131. doi: 10.1111/head.14784. Epub 2024 Oct 1. Headache. 2025. PMID: 39352055 Free PMC article.
Developmental language disorder - heritability and genetic correlations with other disorders affecting language.
Nudel R, Chrsitensen RV, Kalnak N, Lundberg M, Schwinn M, Sørensen E, Mikkelsen C, Nissen J, Christoffersen LAN, Kjerulff BD, Hansen TF, Burgdorf KS; DBDS Genomic Consortium; Pedersen OBV, Erikstrup C, Gísladóttir RS, Walters GB, Stefánsson H, Ostrowski SR, Werge T. Nudel R, et al. Psychiatry Res. 2024 Dec;342:116212. doi: 10.1016/j.psychres.2024.116212. Epub 2024 Sep 21. Psychiatry Res. 2024. PMID: 39348781 Free article.
The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.
Don J, Schork AJ, Glusman G, Rappaport N, Cummings SR, Duggan D, Raju A, Hellberg KG, Gunn S, Monti S, Perls T, Lapidus J, Goetz LH, Sebastiani P, Schork NJ. Don J, et al. Among authors: schork aj, schork nj. Geroscience. 2024 Aug;46(4):3911-3927. doi: 10.1007/s11357-024-01107-1. Epub 2024 Mar 7. Geroscience. 2024. PMID: 38451433 Free PMC article.
Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.
Panagiotaropoulou G, Hellberg KG, Coleman JRI, Seok D, Kalman J; Bipolar Disorder Working Group of the Psychiatric Genetics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genetics Consortium; iPSYCH Study Consortium; Mitchell PB, Schofield PR, Forstner AJ, Bauer M, Scott LJ, Pato CN, Pato MT, Li QS, Kirov G, Landén M, Jonsson L, Müller-Myhsok B, Smoller JW, Binder EB, Brückl TM, Czamara D, der Auwera SV, Grabe HJ, Homuth G, Schmidt CO, Potash JB, DePaulo RJ, Goes FS, MacKinnon DF, Mondimore FM, Weissman MM, Shi J, Frye MA, Biernacka JM, Reif A, Witt SH, Kahn RR, Boks MM, Owen MJ, Gordon-Smith K, Mitchell BL, Martin NG, Medland SE, Jones L, Knowles JA, Levinson DF, O'Donovan MC, Lewis CM, Breen G, Werge T, Schork AJ, Ophoff R, Ripke S, Loohuis LO. Panagiotaropoulou G, et al. Among authors: schork aj. medRxiv [Preprint]. 2024 Jan 30:2024.01.29.24301816. doi: 10.1101/2024.01.29.24301816. medRxiv. 2024. Update in: Br J Psychiatry. 2025 Feb;226(2):79-90. doi: 10.1192/bjp.2024.125. PMID: 38410442 Free PMC article. Updated. Preprint.
Publisher Correction: Population genomics of post-glacial western Eurasia.
Allentoft ME, Sikora M, Refoyo-Martínez A, Irving-Pease EK, Fischer A, Barrie W, Ingason A, Stenderup J, Sjögren KG, Pearson A, Sousa da Mota B, Schulz Paulsson B, Halgren A, Macleod R, Jørkov MLS, Demeter F, Sørensen L, Nielsen PO, Henriksen RA, Vimala T, McColl H, Margaryan A, Ilardo M, Vaughn A, Fischer Mortensen M, Nielsen AB, Ulfeldt Hede M, Johannsen NN, Rasmussen P, Vinner L, Renaud G, Stern A, Jensen TZT, Scorrano G, Schroeder H, Lysdahl P, Ramsøe AD, Skorobogatov A, Schork AJ, Rosengren A, Ruter A, Outram A, Timoshenko AA, Buzhilova A, Coppa A, Zubova A, Silva AM, Hansen AJ, Gromov A, Logvin A, Gotfredsen AB, Henning Nielsen B, González-Rabanal B, Lalueza-Fox C, McKenzie CJ, Gaunitz C, Blasco C, Liesau C, Martinez-Labarga C, Pozdnyakov DV, Cuenca-Solana D, Lordkipanidze DO, En'shin D, Salazar-García DC, Price TD, Borić D, Kostyleva E, Veselovskaya EV, Usmanova ER, Cappellini E, Brinch Petersen E, Kannegaard E, Radina F, Eylem Yediay F, Duday H, Gutiérrez-Zugasti I, Merts I, Potekhina I, Shevnina I, Altinkaya I, Guilaine J, Hansen J, Aura Tortosa JE, Zilhão J, Vega J, Buck Pedersen K, Tunia K, Zhao L, Mylnikova LN, Larsson L, Metz L, Yepiskoposyan L, Pedersen L, Sar… See abstract for full author list ➔ Allentoft ME, et al. Among authors: schork aj. Nature. 2024 Feb;626(7997):E3. doi: 10.1038/s41586-024-07044-5. Nature. 2024. PMID: 38238538 Free PMC article. No abstract available.
Population genomics of post-glacial western Eurasia.
Allentoft ME, Sikora M, Refoyo-Martínez A, Irving-Pease EK, Fischer A, Barrie W, Ingason A, Stenderup J, Sjögren KG, Pearson A, Sousa da Mota B, Schulz Paulsson B, Halgren A, Macleod R, Jørkov MLS, Demeter F, Sørensen L, Nielsen PO, Henriksen RA, Vimala T, McColl H, Margaryan A, Ilardo M, Vaughn A, Fischer Mortensen M, Nielsen AB, Ulfeldt Hede M, Johannsen NN, Rasmussen P, Vinner L, Renaud G, Stern A, Jensen TZT, Scorrano G, Schroeder H, Lysdahl P, Ramsøe AD, Skorobogatov A, Schork AJ, Rosengren A, Ruter A, Outram A, Timoshenko AA, Buzhilova A, Coppa A, Zubova A, Silva AM, Hansen AJ, Gromov A, Logvin A, Gotfredsen AB, Henning Nielsen B, González-Rabanal B, Lalueza-Fox C, McKenzie CJ, Gaunitz C, Blasco C, Liesau C, Martinez-Labarga C, Pozdnyakov DV, Cuenca-Solana D, Lordkipanidze DO, En'shin D, Salazar-García DC, Price TD, Borić D, Kostyleva E, Veselovskaya EV, Usmanova ER, Cappellini E, Brinch Petersen E, Kannegaard E, Radina F, Eylem Yediay F, Duday H, Gutiérrez-Zugasti I, Merts I, Potekhina I, Shevnina I, Altinkaya I, Guilaine J, Hansen J, Aura Tortosa JE, Zilhão J, Vega J, Buck Pedersen K, Tunia K, Zhao L, Mylnikova LN, Larsson L, Metz L, Yepiskoposyan L, Pedersen L, Sar… See abstract for full author list ➔ Allentoft ME, et al. Among authors: schork aj. Nature. 2024 Jan;625(7994):301-311. doi: 10.1038/s41586-023-06865-0. Epub 2024 Jan 10. Nature. 2024. PMID: 38200295 Free PMC article.
100 ancient genomes show repeated population turnovers in Neolithic Denmark.
Allentoft ME, Sikora M, Fischer A, Sjögren KG, Ingason A, Macleod R, Rosengren A, Schulz Paulsson B, Jørkov MLS, Novosolov M, Stenderup J, Price TD, Fischer Mortensen M, Nielsen AB, Ulfeldt Hede M, Sørensen L, Nielsen PO, Rasmussen P, Jensen TZT, Refoyo-Martínez A, Irving-Pease EK, Barrie W, Pearson A, Sousa da Mota B, Demeter F, Henriksen RA, Vimala T, McColl H, Vaughn A, Vinner L, Renaud G, Stern A, Johannsen NN, Ramsøe AD, Schork AJ, Ruter A, Gotfredsen AB, Henning Nielsen B, Brinch Petersen E, Kannegaard E, Hansen J, Buck Pedersen K, Pedersen L, Klassen L, Meldgaard M, Johansen M, Uldum OC, Lotz P, Lysdahl P, Bangsgaard P, Petersen PV, Maring R, Iversen R, Wåhlin S, Anker Sørensen S, Andersen SH, Jørgensen T, Lynnerup N, Lawson DJ, Rasmussen S, Korneliussen TS, Kjær KH, Durbin R, Nielsen R, Delaneau O, Werge T, Kristiansen K, Willerslev E. Allentoft ME, et al. Among authors: schork aj. Nature. 2024 Jan;625(7994):329-337. doi: 10.1038/s41586-023-06862-3. Epub 2024 Jan 10. Nature. 2024. PMID: 38200294 Free PMC article.
The selection landscape and genetic legacy of ancient Eurasians.
Irving-Pease EK, Refoyo-Martínez A, Barrie W, Ingason A, Pearson A, Fischer A, Sjögren KG, Halgren AS, Macleod R, Demeter F, Henriksen RA, Vimala T, McColl H, Vaughn AH, Speidel L, Stern AJ, Scorrano G, Ramsøe A, Schork AJ, Rosengren A, Zhao L, Kristiansen K, Iversen AKN, Fugger L, Sudmant PH, Lawson DJ, Durbin R, Korneliussen T, Werge T, Allentoft ME, Sikora M, Nielsen R, Racimo F, Willerslev E. Irving-Pease EK, et al. Among authors: schork aj. Nature. 2024 Jan;625(7994):312-320. doi: 10.1038/s41586-023-06705-1. Epub 2024 Jan 10. Nature. 2024. PMID: 38200293 Free PMC article.
Population-based Risk of Psychiatric Disorders Associated with Recurrent CNVs.
Vaez M, Montalbano S, Sánchez XC, Georgii Hellberg KL, Rasekhi Dehkordi S, Dybdahl Krebs M, Meijsen J, Shorter J, Byberg-Grauholm J, Mortensen PB, Børglum AD, Hougaard DM, Nordentoft M, Geschwind DH, Buil A, Schork AJ; iPSYCH Investigators; Helenius D, Raznahan A, Thompson WK, Werge T, Ingason A. Vaez M, et al. Among authors: schork aj. medRxiv [Preprint]. 2023 Sep 5:2023.09.04.23294975. doi: 10.1101/2023.09.04.23294975. medRxiv. 2023. Update in: JAMA Psychiatry. 2024 Oct 1;81(10):957-966. doi: 10.1001/jamapsychiatry.2024.1453. PMID: 37886536 Free PMC article. Updated. Preprint.
ADuLT: An efficient and robust time-to-event GWAS.
Pedersen EM, Agerbo E, Plana-Ripoll O, Steinbach J, Krebs MD, Hougaard DM, Werge T, Nordentoft M, Børglum AD, Musliner KL, Ganna A, Schork AJ, Mortensen PB, McGrath JJ, Privé F, Vilhjálmsson BJ. Pedersen EM, et al. Among authors: schork aj. Nat Commun. 2023 Sep 9;14(1):5553. doi: 10.1038/s41467-023-41210-z. Nat Commun. 2023. PMID: 37689771 Free PMC article.
Multi-PGS enhances polygenic prediction by combining 937 polygenic scores.
Albiñana C, Zhu Z, Schork AJ, Ingason A, Aschard H, Brikell I, Bulik CM, Petersen LV, Agerbo E, Grove J, Nordentoft M, Hougaard DM, Werge T, Børglum AD, Mortensen PB, McGrath JJ, Neale BM, Privé F, Vilhjálmsson BJ. Albiñana C, et al. Among authors: schork aj. Nat Commun. 2023 Aug 5;14(1):4702. doi: 10.1038/s41467-023-40330-w. Nat Commun. 2023. PMID: 37543680 Free PMC article.
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.
Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Słomka M, Smith BH, Smolarz B, Szaflik T, Szyłło K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI; DBDS Genomic Cons… See abstract for full author list ➔ Rahmioglu N, et al. Among authors: schork aj. Nat Genet. 2023 Mar;55(3):423-436. doi: 10.1038/s41588-023-01323-z. Epub 2023 Mar 13. Nat Genet. 2023. PMID: 36914876 Free PMC article.
Polygenic analyses show important differences between MDD symptoms collected using PHQ9 and CIDI-SF.
Huang L, Tang S, Rietkerk J, Appadurai V, Krebs MD, Schork AJ, Werge T, Zuber V, Kendler K, Cai N. Huang L, et al. Among authors: schork aj. medRxiv [Preprint]. 2023 Mar 1:2023.02.27.23286527. doi: 10.1101/2023.02.27.23286527. medRxiv. 2023. Update in: Biol Psychiatry. 2024 Jun 15;95(12):1110-1121. doi: 10.1016/j.biopsych.2023.11.021. PMID: 36909638 Free PMC article. Updated. Preprint.
Associations of psychiatric disorders with sex chromosome aneuploidies in the Danish iPSYCH2015 dataset: a case-cohort study.
Sánchez XC, Montalbano S, Vaez M, Krebs MD, Byberg-Grauholm J, Mortensen PB, Børglum AD, Hougaard DM, Nordentoft M, Geschwind DH, Buil A, Schork AJ, Thompson WK, Raznahan A, Helenius D, Werge T, Ingason A. Sánchez XC, et al. Among authors: schork aj. Lancet Psychiatry. 2023 Feb;10(2):129-138. doi: 10.1016/S2215-0366(23)00004-4. Lancet Psychiatry. 2023. PMID: 36697121 Free PMC article.