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Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening.
Flitsch LJ, Börner K, Stüllein C, Ziegler S, Sonntag-Buck V, Wiedtke E, Semkova V, Au Yeung SWC, Schlee J, Hajo M, Mathews M, Ludwig BS, Kossatz S, Kessler H, Grimm D, Brüstle O. Flitsch LJ, et al. Among authors: brustle o. Sci Rep. 2022 May 19;12(1):8356. doi: 10.1038/s41598-022-12404-0. Sci Rep. 2022. PMID: 35589936 Free PMC article.
High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling.
Manstein F, Ullmann K, Kropp C, Halloin C, Triebert W, Franke A, Farr CM, Sahabian A, Haase A, Breitkreuz Y, Peitz M, Brüstle O, Kalies S, Martin U, Olmer R, Zweigerdt R. Manstein F, et al. Among authors: brustle o. Stem Cells Transl Med. 2021 Jul;10(7):1063-1080. doi: 10.1002/sctm.20-0453. Epub 2021 Mar 4. Stem Cells Transl Med. 2021. PMID: 33660952 Free PMC article.
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons.
Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM. Yang NJ, et al. Among authors: brustle o. Nat Neurosci. 2022 Feb;25(2):168-179. doi: 10.1038/s41593-021-00973-8. Epub 2021 Dec 20. Nat Neurosci. 2022. PMID: 34931070 Free PMC article.
Stem cell programming - prospects for perinatal medicine.
Berg LJ, Brüstle O. Berg LJ, et al. Among authors: brustle o. J Perinat Med. 2023 Feb 22;51(6):730-736. doi: 10.1515/jpm-2022-0575. Print 2023 Jul 26. J Perinat Med. 2023. PMID: 36809086 Free article. Review.
Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).
Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang SM, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo SK, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh SK, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan BZ, Zeng F, Zhou Q. Andrews PW, et al. Among authors: brustle o. Regen Med. 2015;10(2 Suppl):1-44. doi: 10.2217/rme.14.93. Regen Med. 2015. PMID: 25675265 No abstract available.
A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma.
Kebir S, Ullrich V, Berger P, Dobersalske C, Langer S, Rauschenbach L, Trageser D, Till A, Lorbeer FK, Wieland A, Wilhelm-Buchstab T, Ahmad A, Fröhlich H, Cima I, Prasad S, Matschke J, Jendrossek V, Remke M, Grüner BM, Roesch A, Siveke JT, Herold-Mende C, Blau T, Keyvani K, van Landeghem FKH, Pietsch T, Felsberg J, Reifenberger G, Weller M, Sure U, Brüstle O, Simon M, Glas M, Scheffler B. Kebir S, et al. Among authors: brustle o. Clin Cancer Res. 2023 Jan 17;29(2):488-500. doi: 10.1158/1078-0432.CCR-22-0611. Clin Cancer Res. 2023. PMID: 36239995 Free PMC article.
Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell-derived sensory neurons.
Röderer P, Belu A, Heidrich L, Siobal M, Isensee J, Prolingheuer J, Janocha E, Valdor M, Hagendorf S, Bahrenberg G, Opitz T, Segschneider M, Haupt S, Nitzsche A, Brüstle O, Hucho T. Röderer P, et al. Among authors: brustle o. Pain. 2023 Aug 1;164(8):1718-1733. doi: 10.1097/j.pain.0000000000002860. Epub 2023 Jan 19. Pain. 2023. PMID: 36727909 Free PMC article.
High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification.
Vuidel A, Cousin L, Weykopf B, Haupt S, Hanifehlou Z, Wiest-Daesslé N, Segschneider M, Lee J, Kwon YJ, Peitz M, Ogier A, Brino L, Brüstle O, Sommer P, Wilbertz JH. Vuidel A, et al. Among authors: brustle o. Stem Cell Reports. 2022 Oct 11;17(10):2349-2364. doi: 10.1016/j.stemcr.2022.09.001. Epub 2022 Sep 29. Stem Cell Reports. 2022. PMID: 36179692 Free PMC article.
ADHD-associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient-derived cell lines.
Radtke F, Palladino VS, McNeill RV, Chiocchetti AG, Haslinger D, Leyh M, Gersic D, Frank M, Grünewald L, Klebe S, Brüstle O, Günther K, Edenhofer F, Kranz TM, Reif A, Kittel-Schneider S. Radtke F, et al. Among authors: brustle o. Am J Med Genet B Neuropsychiatr Genet. 2022 Oct;189(7-8):257-270. doi: 10.1002/ajmg.b.32918. Epub 2022 Aug 16. Am J Med Genet B Neuropsychiatr Genet. 2022. PMID: 35971782
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton.
Wolf C, Pouya A, Bitar S, Pfeiffer A, Bueno D, Rojas-Charry L, Arndt S, Gomez-Zepeda D, Tenzer S, Bello FD, Vianello C, Ritz S, Schwirz J, Dobrindt K, Peitz M, Hanschmann EM, Mencke P, Boussaad I, Silies M, Brüstle O, Giacomello M, Krüger R, Methner A. Wolf C, et al. Among authors: brustle o. Commun Biol. 2022 Jun 3;5(1):541. doi: 10.1038/s42003-022-03487-6. Commun Biol. 2022. PMID: 35662277 Free PMC article.
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.
Schmid B, Holst B, Clausen C, Bahnassawy L, Reinhardt P, Bakker MHM, Díaz-Guerra E, Vicario C, Martino-Adami PV, Thoenes M, Ramirez A, Fliessbach K, Grezella C, Brüstle O, Peitz M, Ebneth A, Cabrera-Socorro A. Schmid B, et al. Among authors: brustle o. Stem Cell Res. 2021 Apr;52:102180. doi: 10.1016/j.scr.2021.102180. Epub 2021 Feb 2. Stem Cell Res. 2021. PMID: 33556820 Free article.
Energy Metabolism Disturbances in Cell Models of PARK2 CNV Carriers with ADHD.
Palladino VS, Chiocchetti AG, Frank L, Haslinger D, McNeill R, Radtke F, Till A, Haupt S, Brüstle O, Günther K, Edenhofer F, Hoffmann P, Reif A, Kittel-Schneider S. Palladino VS, et al. Among authors: brustle o. J Clin Med. 2020 Dec 18;9(12):4092. doi: 10.3390/jcm9124092. J Clin Med. 2020. PMID: 33353000 Free PMC article.
Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status.
Piotrowski T, Rippel O, Elanzew A, Nießing B, Stucken S, Jung S, König N, Haupt S, Stappert L, Brüstle O, Schmitt R, Jonas S. Piotrowski T, et al. Among authors: brustle o. Comput Biol Med. 2021 Feb;129:104172. doi: 10.1016/j.compbiomed.2020.104172. Epub 2020 Dec 11. Comput Biol Med. 2021. PMID: 33352307 Free article.
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region.
Ibach M, Mathews M, Linnartz-Gerlach B, Theil S, Kumar S, Feederle R, Brüstle O, Neumann H, Walter J. Ibach M, et al. Among authors: brustle o. Glia. 2021 May;69(5):1126-1139. doi: 10.1002/glia.23953. Epub 2020 Dec 14. Glia. 2021. PMID: 33314333
The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells.
Elanzew A, Nießing B, Langendoerfer D, Rippel O, Piotrowski T, Schenk F, Kulik M, Peitz M, Breitkreuz Y, Jung S, Wanek P, Stappert L, Schmitt RH, Haupt S, Zenke M, König N, Brüstle O. Elanzew A, et al. Among authors: brustle o. Front Bioeng Biotechnol. 2020 Nov 9;8:580352. doi: 10.3389/fbioe.2020.580352. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 33240865 Free PMC article.
Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures.
Tabari D, Scholl C, Steffens M, Weickhardt S, Elgner F, Bender D, Herrlein ML, Sabino C, Semkova V, Peitz M, Till A, Brüstle O, Hildt E, Stingl J. Tabari D, et al. Among authors: brustle o. Viruses. 2020 Oct 27;12(11):1219. doi: 10.3390/v12111219. Viruses. 2020. PMID: 33121145 Free PMC article.
Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma.
Rauschenbach L, Wieland A, Reinartz R, Kebir S, Till A, Darkwah Oppong M, Dobersalske C, Ullrich V, Ahmad A, Jabbarli R, Pierscianek D, Fröhlich H, Simon M, Brüstle O, Sure U, Glas M, Scheffler B. Rauschenbach L, et al. Among authors: brustle o. Eur J Cancer. 2020 Nov;140:130-139. doi: 10.1016/j.ejca.2020.09.017. Epub 2020 Oct 19. Eur J Cancer. 2020. PMID: 33091717
Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models.
Cenini G, Hebisch M, Iefremova V, Flitsch LJ, Breitkreuz Y, Tanzi RE, Kim DY, Peitz M, Brüstle O. Cenini G, et al. Among authors: brustle o. Mol Cell Neurosci. 2021 Jan;110:103568. doi: 10.1016/j.mcn.2020.103568. Epub 2020 Oct 14. Mol Cell Neurosci. 2021. PMID: 33068718 Review.
Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse.
Wiatr K, Piasecki P, Marczak Ł, Wojciechowski P, Kurkowiak M, Płoski R, Rydzanicz M, Handschuh L, Jungverdorben J, Brüstle O, Figlerowicz M, Figiel M. Wiatr K, et al. Among authors: brustle o. Mol Neurobiol. 2019 Dec;56(12):8168-8202. doi: 10.1007/s12035-019-01643-4. Epub 2019 Jun 14. Mol Neurobiol. 2019. PMID: 31201651 Free PMC article.
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Rhee HJ, Shaib AH, Rehbach K, Lee C, Seif P, Thomas C, Gideons E, Guenther A, Krutenko T, Hebisch M, Peitz M, Brose N, Brüstle O, Rhee JS. Rhee HJ, et al. Among authors: brustle o. Cell Rep. 2019 May 14;27(7):2212-2228.e7. doi: 10.1016/j.celrep.2019.04.059. Cell Rep. 2019. PMID: 31091457 Free article.
A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, Peitz M, Toonen RF, Brüstle O, Verhage M. Meijer M, et al. Among authors: brustle o. Cell Rep. 2019 May 14;27(7):2199-2211.e6. doi: 10.1016/j.celrep.2019.04.058. Cell Rep. 2019. PMID: 31091456 Free article.
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch LJ, Eckert D, Hebisch M, Fischer J, Kesavan J, Weykopf B, Schneider L, Holtkamp D, Beck H, Till A, Wüllner U, Ziller MJ, Wagner W, Peitz M, Brüstle O. Sheng C, et al. Among authors: brustle o. Nat Commun. 2018 Oct 2;9(1):4047. doi: 10.1038/s41467-018-06398-5. Nat Commun. 2018. PMID: 30279449 Free PMC article.
Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.
Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E. Merten N, et al. Among authors: brustle o. Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5. doi: 10.1016/j.chembiol.2018.03.012. Epub 2018 Apr 26. Cell Chem Biol. 2018. PMID: 29706593 Free PMC article.
Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia.
Minnerop M, Kurzwelly D, Wagner H, Soehn AS, Reichbauer J, Tao F, Rattay TW, Peitz M, Rehbach K, Giorgetti A, Pyle A, Thiele H, Altmüller J, Timmann D, Karaca I, Lennarz M, Baets J, Hengel H, Synofzik M, Atasu B, Feely S, Kennerson M, Stendel C, Lindig T, Gonzalez MA, Stirnberg R, Sturm M, Roeske S, Jung J, Bauer P, Lohmann E, Herms S, Heilmann-Heimbach S, Nicholson G, Mahanjah M, Sharkia R, Carloni P, Brüstle O, Klopstock T, Mathews KD, Shy ME, de Jonghe P, Chinnery PF, Horvath R, Kohlhase J, Schmitt I, Wolf M, Greschus S, Amunts K, Maier W, Schöls L, Nürnberg P, Zuchner S, Klockgether T, Ramirez A, Schüle R. Minnerop M, et al. Among authors: brustle o. Brain. 2017 Jun 1;140(6):1561-1578. doi: 10.1093/brain/awx095. Brain. 2017. PMID: 28459997 Free PMC article.
Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.
De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brüstle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolén G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE. De Sousa PA, et al. Among authors: o shea o, brustle o. Stem Cell Res. 2017 Apr;20:105-114. doi: 10.1016/j.scr.2017.03.002. Epub 2017 Mar 7. Stem Cell Res. 2017. PMID: 28334554 Free article.
Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli.
Tornero D, Tsupykov O, Granmo M, Rodriguez C, Grønning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brüstle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z. Tornero D, et al. Among authors: brustle o. Brain. 2017 Mar 1;140(3):692-706. doi: 10.1093/brain/aww347. Brain. 2017. PMID: 28115364
Whole-brain 3D mapping of human neural transplant innervation.
Doerr J, Schwarz MK, Wiedermann D, Leinhaas A, Jakobs A, Schloen F, Schwarz I, Diedenhofen M, Braun NC, Koch P, Peterson DA, Kubitscheck U, Hoehn M, Brüstle O. Doerr J, et al. Among authors: brustle o. Nat Commun. 2017 Jan 19;8:14162. doi: 10.1038/ncomms14162. Nat Commun. 2017. PMID: 28102196 Free PMC article.
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D. Schwenk BM, et al. Among authors: brustle o. EMBO J. 2016 Nov 2;35(21):2350-2370. doi: 10.15252/embj.201694221. Epub 2016 Sep 12. EMBO J. 2016. PMID: 27621269 Free PMC article.
Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma.
Reinartz R, Wang S, Kebir S, Silver DJ, Wieland A, Zheng T, Küpper M, Rauschenbach L, Fimmers R, Shepherd TM, Trageser D, Till A, Schäfer N, Glas M, Hillmer AM, Cichon S, Smith AA, Pietsch T, Liu Y, Reynolds BA, Yachnis A, Pincus DW, Simon M, Brüstle O, Steindler DA, Scheffler B. Reinartz R, et al. Among authors: brustle o. Clin Cancer Res. 2017 Jan 15;23(2):562-574. doi: 10.1158/1078-0432.CCR-15-2089. Epub 2016 Aug 12. Clin Cancer Res. 2017. PMID: 27521447 Free PMC article.
Reciprocal Regulation between Bifunctional miR-9/9(∗) and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation.
Roese-Koerner B, Stappert L, Berger T, Braun NC, Veltel M, Jungverdorben J, Evert BO, Peitz M, Borghese L, Brüstle O. Roese-Koerner B, et al. Among authors: brustle o. Stem Cell Reports. 2016 Aug 9;7(2):207-19. doi: 10.1016/j.stemcr.2016.06.008. Epub 2016 Jul 14. Stem Cell Reports. 2016. PMID: 27426040 Free PMC article.
Modeling psychiatric disorders: from genomic findings to cellular phenotypes.
Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S. Falk A, et al. Among authors: brustle o. Mol Psychiatry. 2016 Sep;21(9):1321. doi: 10.1038/mp.2016.100. Epub 2016 Jun 21. Mol Psychiatry. 2016. PMID: 27324182 Free PMC article. No abstract available.
Modeling psychiatric disorders: from genomic findings to cellular phenotypes.
Falk A, Heine VM, Harwood AJ, Sullivan PF, Peitz M, Brüstle O, Shen S, Sun YM, Glover JC, Posthuma D, Djurovic S. Falk A, et al. Among authors: brustle o. Mol Psychiatry. 2016 Sep;21(9):1167-79. doi: 10.1038/mp.2016.89. Epub 2016 May 31. Mol Psychiatry. 2016. PMID: 27240529 Free PMC article. Review.
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.
Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Brennand KJ, et al. Among authors: brustle o. Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21. Stem Cell Reports. 2015. PMID: 26610635 Free PMC article.
Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals.
Heesen L, Peitz M, Torres-Benito L, Hölker I, Hupperich K, Dobrindt K, Jungverdorben J, Ritzenhofen S, Weykopf B, Eckert D, Hosseini-Barkooie SM, Storbeck M, Fusaki N, Lonigro R, Heller R, Kye MJ, Brüstle O, Wirth B. Heesen L, et al. Among authors: brustle o. Cell Mol Life Sci. 2016 May;73(10):2089-104. doi: 10.1007/s00018-015-2084-y. Epub 2015 Nov 16. Cell Mol Life Sci. 2016. PMID: 26573968
Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.
Fernandes TG, Duarte ST, Ghazvini M, Gaspar C, Santos DC, Porteira AR, Rodrigues GM, Haupt S, Rombo DM, Armstrong J, Sebastião AM, Gribnau J, Garcia-Cazorla À, Brüstle O, Henrique D, Cabral JM, Diogo MM. Fernandes TG, et al. Among authors: brustle o. Biotechnol J. 2015 Oct;10(10):1578-88. doi: 10.1002/biot.201400751. Epub 2015 Jun 30. Biotechnol J. 2015. PMID: 26123315
A 3D human neural cell culture system for modeling Alzheimer's disease.
Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY. Kim YH, et al. Among authors: brustle o. Nat Protoc. 2015 Jul;10(7):985-1006. doi: 10.1038/nprot.2015.065. Epub 2015 Jun 11. Nat Protoc. 2015. PMID: 26068894 Free PMC article.
Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.
Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Ruschel J, et al. Among authors: brustle o. Science. 2015 Apr 17;348(6232):347-52. doi: 10.1126/science.aaa2958. Epub 2015 Mar 12. Science. 2015. PMID: 25765066 Free PMC article.
Derivation and maintenance of murine trophoblast stem cells under defined conditions.
Kubaczka C, Senner C, Araúzo-Bravo MJ, Sharma N, Kuckenberg P, Becker A, Zimmer A, Brüstle O, Peitz M, Hemberger M, Schorle H. Kubaczka C, et al. Among authors: brustle o. Stem Cell Reports. 2014 Jan 30;2(2):232-42. doi: 10.1016/j.stemcr.2013.12.013. eCollection 2014 Feb 11. Stem Cell Reports. 2014. PMID: 24527396 Free PMC article.
Correction: MicroRNA-Based Promotion of Human Neuronal Differentiation and Subtype Specification.
Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brüstle O. Stappert L, et al. Among authors: brustle o. PLoS One. 2013 Sep 12;8(9):10.1371/annotation/b03fbc42-8f70-4873-9cce-854e48249a13. doi: 10.1371/annotation/b03fbc42-8f70-4873-9cce-854e48249a13. eCollection 2013. PLoS One. 2013. PMID: 29294475 Free PMC article.
Anticancer effects of niclosamide in human glioblastoma.
Wieland A, Trageser D, Gogolok S, Reinartz R, Höfer H, Keller M, Leinhaas A, Schelle R, Normann S, Klaas L, Waha A, Koch P, Fimmers R, Pietsch T, Yachnis AT, Pincus DW, Steindler DA, Brüstle O, Simon M, Glas M, Scheffler B. Wieland A, et al. Among authors: brustle o. Clin Cancer Res. 2013 Aug 1;19(15):4124-36. doi: 10.1158/1078-0432.CCR-12-2895. Clin Cancer Res. 2013. PMID: 23908450
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls.
Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. Bianco P, et al. Among authors: brustle o. EMBO J. 2013 May 29;32(11):1489-95. doi: 10.1038/emboj.2013.114. Epub 2013 May 3. EMBO J. 2013. PMID: 23644381 Free PMC article.
Disease-specific iPS cell models in neuroscience.
Peitz M, Jungverdorben J, Brüstle O. Peitz M, et al. Among authors: brustle o. Curr Mol Med. 2013 Jun;13(5):832-41. doi: 10.2174/1566524011313050014. Curr Mol Med. 2013. PMID: 23642064 Review.
Automated selection and harvesting of pluripotent stem cell colonies.
Haupt S, Grützner J, Thier MC, Kallweit T, Rath BH, Laufenberg I, Forgber M, Eberhardt J, Edenhofer F, Brüstle O. Haupt S, et al. Among authors: brustle o. Biotechnol Appl Biochem. 2012 Mar-Apr;59(2):77-87. doi: 10.1002/bab.1014. Biotechnol Appl Biochem. 2012. PMID: 23586788
Embryonic stem cell-based modeling of tau pathology in human neurons.
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