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Page 1
Multimodal Machine Learning Workflows for Prediction of Psychosis in Patients With Clinical High-Risk Syndromes and Recent-Onset Depression.
Koutsouleris N, Dwyer DB, Degenhardt F, Maj C, Urquijo-Castro MF, Sanfelici R, Popovic D, Oeztuerk O, Haas SS, Weiske J, Ruef A, Kambeitz-Ilankovic L, Antonucci LA, Neufang S, Schmidt-Kraepelin C, Ruhrmann S, Penzel N, Kambeitz J, Haidl TK, Rosen M, Chisholm K, Riecher-Rössler A, Egloff L, Schmidt A, Andreou C, Hietala J, Schirmer T, Romer G, Walger P, Franscini M, Traber-Walker N, Schimmelmann BG, Flückiger R, Michel C, Rössler W, Borisov O, Krawitz PM, Heekeren K, Buechler R, Pantelis C, Falkai P, Salokangas RKR, Lencer R, Bertolino A, Borgwardt S, Noethen M, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Theodoridou A, Meisenzahl E; PRONIA Consortium. Koutsouleris N, et al. Among authors: bertolino a. JAMA Psychiatry. 2021 Feb 1;78(2):195-209. doi: 10.1001/jamapsychiatry.2020.3604. JAMA Psychiatry. 2021. PMID: 33263726 Free PMC article.
Converging evidence for the association of functional genetic variation in the serotonin receptor 2a gene with prefrontal function and olanzapine treatment.
Blasi G, De Virgilio C, Papazacharias A, Taurisano P, Gelao B, Fazio L, Ursini G, Sinibaldi L, Andriola I, Masellis R, Romano R, Rampino A, Di Giorgio A, Lo Bianco L, Caforio G, Piva F, Popolizio T, Bellantuono C, Todarello O, Kleinman JE, Gadaleta G, Weinberger DR, Bertolino A. Blasi G, et al. Among authors: bertolino a. JAMA Psychiatry. 2013 Sep;70(9):921-30. doi: 10.1001/jamapsychiatry.2013.1378. JAMA Psychiatry. 2013. PMID: 23842608 Clinical Trial.
Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control.
Antonucci LA, Taurisano P, Fazio L, Gelao B, Romano R, Quarto T, Porcelli A, Mancini M, Di Giorgio A, Caforio G, Pergola G, Popolizio T, Bertolino A, Blasi G. Antonucci LA, et al. Among authors: bertolino a. Schizophr Res. 2016 May;173(1-2):23-9. doi: 10.1016/j.schres.2016.03.014. Epub 2016 Mar 21. Schizophr Res. 2016. PMID: 27012899
Altered Functional Subnetwork During Emotional Face Processing: A Potential Intermediate Phenotype for Schizophrenia.
Cao H, Bertolino A, Walter H, Schneider M, Schäfer A, Taurisano P, Blasi G, Haddad L, Grimm O, Otto K, Dixson L, Erk S, Mohnke S, Heinz A, Romanczuk-Seiferth N, Mühleisen TW, Mattheisen M, Witt SH, Cichon S, Noethen M, Rietschel M, Tost H, Meyer-Lindenberg A. Cao H, et al. Among authors: bertolino a. JAMA Psychiatry. 2016 Jun 1;73(6):598-605. doi: 10.1001/jamapsychiatry.2016.0161. JAMA Psychiatry. 2016. PMID: 27145286
Interplay Among Psychopathologic Variables, Personal Resources, Context-Related Factors, and Real-life Functioning in Individuals With Schizophrenia: A Network Analysis.
Galderisi S, Rucci P, Kirkpatrick B, Mucci A, Gibertoni D, Rocca P, Rossi A, Bertolino A, Strauss GP, Aguglia E, Bellomo A, Murri MB, Bucci P, Carpiniello B, Comparelli A, Cuomo A, De Berardis D, Dell'Osso L, Di Fabio F, Gelao B, Marchesi C, Monteleone P, Montemagni C, Orsenigo G, Pacitti F, Roncone R, Santonastaso P, Siracusano A, Vignapiano A, Vita A, Zeppegno P, Maj M; Italian Network for Research on Psychoses. Galderisi S, et al. Among authors: bertolino a. JAMA Psychiatry. 2018 Apr 1;75(4):396-404. doi: 10.1001/jamapsychiatry.2017.4607. JAMA Psychiatry. 2018. PMID: 29450447 Free PMC article.
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, Pearlson GD, Yao N, Fukunaga M, Hashimoto R, Okada N, Yamamori H, Bustillo JR, Clark VP, Agartz I, Mueller BA, Cahn W, de Zwarte SMC, Hulshoff Pol HE, Kahn RS, Ophoff RA, van Haren NEM, Andreassen OA, Dale AM, Doan NT, Gurholt TP, Hartberg CB, Haukvik UK, Jørgensen KN, Lagerberg TV, Melle I, Westlye LT, Gruber O, Kraemer B, Richter A, Zilles D, Calhoun VD, Crespo-Facorro B, Roiz-Santiañez R, Tordesillas-Gutiérrez D, Loughland C, Carr VJ, Catts S, Cropley VL, Fullerton JM, Green MJ, Henskens FA, Jablensky A, Lenroot RK, Mowry BJ, Michie PT, Pantelis C, Quidé Y, Schall U, Scott RJ, Cairns MJ, Seal M, Tooney PA, Rasser PE, Cooper G, Shannon Weickert C, Weickert TW, Morris DW, Hong E, Kochunov P, Beard LM, Gur RE, Gur RC, Satterthwaite TD, Wolf DH, Belger A, Brown GG, Ford JM, Macciardi F, Mathalon DH, O'Leary DS, Potkin SG, Preda A, Voyvodic J, Lim KO, McEwen S, Yang F, Tan Y, Tan S, Wang Z, Fan F, Chen J, Xiang H, Tang S, Guo H, Wan P, Wei D, Bockholt HJ, Ehrlich S, Wolthusen RPF, King MD, Shoemaker JM, Sponheim SR, De Haan L, Koenders L, Machielsen MW, van Amelsvoort T, Veltman DJ, Assogna F, Banaj N, de Rossi P, Iorio … See abstract for full author list ➔ van Erp TGM, et al. Among authors: bertolino a. Biol Psychiatry. 2018 Nov 1;84(9):644-654. doi: 10.1016/j.biopsych.2018.04.023. Epub 2018 May 14. Biol Psychiatry. 2018. PMID: 29960671 Free PMC article.
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?
van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, Pearlson GD, Yao N, Fukunaga M, Hashimoto R, Okada N, Yamamori H, Clark VP, Mueller BA, de Zwarte SMC, Ophoff RA, van Haren NEM, Andreassen OA, Gurholt TP, Gruber O, Kraemer B, Richter A, Calhoun VD, Crespo-Facorro B, Roiz-Santiañez R, Tordesillas-Gutiérrez D, Loughland C, Catts S, Fullerton JM, Green MJ, Henskens F, Jablensky A, Mowry BJ, Pantelis C, Quidé Y, Schall U, Scott RJ, Cairns MJ, Seal M, Tooney PA, Rasser PE, Cooper G, Shannon Weickert C, Weickert TW, Hong E, Kochunov P, Gur RE, Gur RC, Ford JM, Macciardi F, Mathalon DH, Potkin SG, Preda A, Fan F, Ehrlich S, King MD, De Haan L, Veltman DJ, Assogna F, Banaj N, de Rossi P, Iorio M, Piras F, Spalletta G, Pomarol-Clotet E, Kelly S, Ciufolini S, Radua J, Murray R, Marques TR, Simmons A, Borgwardt S, Schönborn-Harrisberger F, Riecher-Rössler A, Smieskova R, Alpert KI, Bertolino A, Bonvino A, Di Giorgio A, Neilson E, Mayer AR, Yun JY, Cannon DM, Lebedeva I, Tomyshev AS, Akhadov T, Kaleda V, Fatouros-Bergman H, Flyckt L; Karolinska Schizophrenia Project; Rosa PGP, Serpa MH, Zanetti MV, Hoschl C, Skoch A, Spaniel F, Tomecek D, McIntosh AM, Whalley HC, Knöchel … See abstract for full author list ➔ van Erp TGM, et al. Among authors: bertolino a. Biol Psychiatry. 2019 Apr 1;85(7):e35-e39. doi: 10.1016/j.biopsych.2018.10.003. Epub 2018 Nov 22. Biol Psychiatry. 2019. PMID: 30470561 Free PMC article. No abstract available.
Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder.
Schwarz E, Doan NT, Pergola G, Westlye LT, Kaufmann T, Wolfers T, Brecheisen R, Quarto T, Ing AJ, Di Carlo P, Gurholt TP, Harms RL, Noirhomme Q, Moberget T, Agartz I, Andreassen OA, Bellani M, Bertolino A, Blasi G, Brambilla P, Buitelaar JK, Cervenka S, Flyckt L, Frangou S, Franke B, Hall J, Heslenfeld DJ, Kirsch P, McIntosh AM, Nöthen MM, Papassotiropoulos A, de Quervain DJ, Rietschel M, Schumann G, Tost H, Witt SH, Zink M, Meyer-Lindenberg A; IMAGEMEND Consortium, Karolinska Schizophrenia Project (KaSP) Consortium. Schwarz E, et al. Among authors: bertolino a. Transl Psychiatry. 2019 Jan 17;9(1):12. doi: 10.1038/s41398-018-0225-4. Transl Psychiatry. 2019. PMID: 30664633 Free PMC article.
Thalamic connectivity measured with fMRI is associated with a polygenic index predicting thalamo-prefrontal gene co-expression.
Antonucci LA, Di Carlo P, Passiatore R, Papalino M, Monda A, Amoroso N, Tangaro S, Taurisano P, Rampino A, Sambataro F, Popolizio T, Bertolino A, Pergola G, Blasi G. Antonucci LA, et al. Among authors: bertolino a. Brain Struct Funct. 2019 Apr;224(3):1331-1344. doi: 10.1007/s00429-019-01843-7. Epub 2019 Feb 6. Brain Struct Funct. 2019. PMID: 30725232
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.
Alnæs D, Kaufmann T, van der Meer D, Córdova-Palomera A, Rokicki J, Moberget T, Bettella F, Agartz I, Barch DM, Bertolino A, Brandt CL, Cervenka S, Djurovic S, Doan NT, Eisenacher S, Fatouros-Bergman H, Flyckt L, Di Giorgio A, Haatveit B, Jönsson EG, Kirsch P, Lund MJ, Meyer-Lindenberg A, Pergola G, Schwarz E, Smeland OB, Quarto T, Zink M, Andreassen OA, Westlye LT; Karolinska Schizophrenia Project Consortium. Alnæs D, et al. Among authors: bertolino a. JAMA Psychiatry. 2019 Jul 1;76(7):739-748. doi: 10.1001/jamapsychiatry.2019.0257. JAMA Psychiatry. 2019. PMID: 30969333 Free PMC article.
The interaction between OXTR rs2268493 and perceived maternal care is associated with amygdala-dorsolateral prefrontal effective connectivity during explicit emotion processing.
Antonucci LA, Pergola G, Passiatore R, Taurisano P, Quarto T, Dispoto E, Rampino A, Bertolino A, Cassibba R, Blasi G. Antonucci LA, et al. Among authors: bertolino a. Eur Arch Psychiatry Clin Neurosci. 2020 Aug;270(5):553-565. doi: 10.1007/s00406-019-01062-5. Epub 2019 Aug 30. Eur Arch Psychiatry Clin Neurosci. 2020. PMID: 31471679
Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity.
Antonucci LA, Penzel N, Pergola G, Kambeitz-Ilankovic L, Dwyer D, Kambeitz J, Haas SS, Passiatore R, Fazio L, Caforio G, Falkai P, Blasi G, Bertolino A, Koutsouleris N. Antonucci LA, et al. Among authors: bertolino a. Neuropsychopharmacology. 2020 Mar;45(4):613-621. doi: 10.1038/s41386-019-0532-3. Epub 2019 Oct 3. Neuropsychopharmacology. 2020. PMID: 31581175 Free PMC article.
An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.
Wong TY, Radua J, Pomarol-Clotet E, Salvador R, Albajes-Eizagirre A, Solanes A, Canales-Rodriguez EJ, Guerrero-Pedraza A, Sarro S, Kircher T, Nenadic I, Krug A, Grotegerd D, Dannlowski U, Borgwardt S, Riecher-Rössler A, Schmidt A, Andreou C, Huber CG, Turner J, Calhoun V, Jiang W, Clark S, Walton E, Spalletta G, Banaj N, Piras F, Ciullo V, Vecchio D, Lebedeva I, Tomyshev AS, Kaleda V, Klushnik T, Filho GB, Zanetti MV, Serpa MH, Penteado Rosa PG, Hashimoto R, Fukunaga M, Richter A, Krämer B, Gruber O, Voineskos AN, Dickie EW, Tomecek D, Skoch A, Spaniel F, Hoschl C, Bertolino A, Bonvino A, Di Giorgio A, Holleran L, Ciufolini S, Marques TR, Dazzan P, Murray R, Lamsma J, Cahn W, van Haren N, Díaz-Zuluaga AM, Pineda-Zapata JA, Vargas C, López-Jaramillo C, van Erp TGM, Gur RC, Nickl-Jockschat T. Wong TY, et al. Among authors: bertolino a. Psychol Med. 2020 Sep;50(12):2034-2045. doi: 10.1017/S0033291719002149. Epub 2019 Oct 16. Psychol Med. 2020. PMID: 31615588
A Pattern of Cognitive Deficits Stratified for Genetic and Environmental Risk Reliably Classifies Patients With Schizophrenia From Healthy Control Subjects.
Antonucci LA, Pergola G, Pigoni A, Dwyer D, Kambeitz-Ilankovic L, Penzel N, Romano R, Gelao B, Torretta S, Rampino A, Trojano M, Caforio G, Falkai P, Blasi G, Koutsouleris N, Bertolino A. Antonucci LA, et al. Among authors: bertolino a. Biol Psychiatry. 2020 Apr 15;87(8):697-707. doi: 10.1016/j.biopsych.2019.11.007. Epub 2019 Nov 15. Biol Psychiatry. 2020. PMID: 31948640
The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis.
Upthegrove R, Lalousis P, Mallikarjun P, Chisholm K, Griffiths SL, Iqbal M, Pelton M, Reniers R, Stainton A, Rosen M, Ruef A, Dwyer DB, Surman M, Haidl T, Penzel N, Kambeitz-Llankovic L, Bertolino A, Brambilla P, Borgwardt S, Kambeitz J, Lencer R, Pantelis C, Ruhrmann S, Schultze-Lutter F, Salokangas RKR, Meisenzahl E, Wood SJ, Koutsouleris N; PRONIA Consortium. Upthegrove R, et al. Among authors: bertolino a. Schizophr Bull. 2021 Jan 23;47(1):249-258. doi: 10.1093/schbul/sbaa094. Schizophr Bull. 2021. PMID: 32634220 Free PMC article. Clinical Trial.
Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes.
Popovic D, Ruef A, Dwyer DB, Antonucci LA, Eder J, Sanfelici R, Kambeitz-Ilankovic L, Oztuerk OF, Dong MS, Paul R, Paolini M, Hedderich D, Haidl T, Kambeitz J, Ruhrmann S, Chisholm K, Schultze-Lutter F, Falkai P, Pergola G, Blasi G, Bertolino A, Lencer R, Dannlowski U, Upthegrove R, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Brambilla P, Borgwardt S, Koutsouleris N; PRONIA Consortium. Popovic D, et al. Among authors: bertolino a. Biol Psychiatry. 2020 Dec 1;88(11):829-842. doi: 10.1016/j.biopsych.2020.05.020. Epub 2020 May 26. Biol Psychiatry. 2020. PMID: 32782139
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.
Writing Committee for the Attention-Deficit/Hyperactivity Disorder; Autism Spectrum Disorder; Bipolar Disorder; Major Depressive Disorder; Obsessive-Compulsive Disorder; and Schizophrenia ENIGMA Working Groups; Patel Y, Parker N, Shin J, Howard D, French L, Thomopoulos SI, Pozzi E, Abe Y, Abé C, Anticevic A, Alda M, Aleman A, Alloza C, Alonso-Lana S, Ameis SH, Anagnostou E, McIntosh AA, Arango C, Arnold PD, Asherson P, Assogna F, Auzias G, Ayesa-Arriola R, Bakker G, Banaj N, Banaschewski T, Bandeira CE, Baranov A, Bargalló N, Bau CHD, Baumeister S, Baune BT, Bellgrove MA, Benedetti F, Bertolino A, Boedhoe PSW, Boks M, Bollettini I, Del Mar Bonnin C, Borgers T, Borgwardt S, Brandeis D, Brennan BP, Bruggemann JM, Bülow R, Busatto GF, Calderoni S, Calhoun VD, Calvo R, Canales-Rodríguez EJ, Cannon DM, Carr VJ, Cascella N, Cercignani M, Chaim-Avancini TM, Christakou A, Coghill D, Conzelmann A, Crespo-Facorro B, Cubillo AI, Cullen KR, Cupertino RB, Daly E, Dannlowski U, Davey CG, Denys D, Deruelle C, Di Giorgio A, Dickie EW, Dima D, Dohm K, Ehrlich S, Ely BA, Erwin-Grabner T, Ethofer T, Fair DA, Fallgatter AJ, Faraone SV, Fatjó-Vilas M, Fedor JM, Fitzgerald KD, Ford JM, Frodl T, … See abstract for full author list ➔ Writing Committee for the Attention-Deficit/Hyperactivity Disorder, et al. Among authors: bertolino a. JAMA Psychiatry. 2021 Jan 1;78(1):47-63. doi: 10.1001/jamapsychiatry.2020.2694. JAMA Psychiatry. 2021. PMID: 32857118 Free PMC article.
Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study.
Walger H, Antonucci LA, Pigoni A, Upthegrove R, Salokangas RKR, Lencer R, Chisholm K, Riecher-Rössler A, Haidl T, Meisenzahl E, Rosen M, Ruhrmann S, Kambeitz J, Kambeitz-Ilankovic L, Falkai P, Ruef A, Hietala J, Pantelis C, Wood SJ, Brambilla P, Bertolino A, Borgwardt S, Koutsouleris N, Schultze-Lutter F. Walger H, et al. Among authors: bertolino a. Front Psychiatry. 2020 Nov 17;11:552175. doi: 10.3389/fpsyt.2020.552175. eCollection 2020. Front Psychiatry. 2020. PMID: 33312133 Free PMC article.
General psychopathology links burden of recent life events and psychotic symptoms in a network approach.
Betz LT, Penzel N, Kambeitz-Ilankovic L, Rosen M, Chisholm K, Stainton A, Haidl TK, Wenzel J, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Ruhrmann S, Salokangas RKR, Schultze-Lutter F, Wood SJ, Upthegrove R, Koutsouleris N, Kambeitz J; PRONIA consortium. Betz LT, et al. Among authors: bertolino a. NPJ Schizophr. 2020 Dec 15;6(1):40. doi: 10.1038/s41537-020-00129-w. NPJ Schizophr. 2020. PMID: 33319805 Free PMC article.
Heterogeneity and Classification of Recent Onset Psychosis and Depression: A Multimodal Machine Learning Approach.
Lalousis PA, Wood SJ, Schmaal L, Chisholm K, Griffiths SL, Reniers RLEP, Bertolino A, Borgwardt S, Brambilla P, Kambeitz J, Lencer R, Pantelis C, Ruhrmann S, Salokangas RKR, Schultze-Lutter F, Bonivento C, Dwyer D, Ferro A, Haidl T, Rosen M, Schmidt A, Meisenzahl E, Koutsouleris N, Upthegrove R; PRONIA Consortium. Lalousis PA, et al. Among authors: bertolino a. Schizophr Bull. 2021 Jul 8;47(4):1130-1140. doi: 10.1093/schbul/sbaa185. Schizophr Bull. 2021. PMID: 33543752 Free PMC article.
Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses.
Mucci A, Galderisi S, Gibertoni D, Rossi A, Rocca P, Bertolino A, Aguglia E, Amore M, Bellomo A, Biondi M, Blasi G, Brasso C, Bucci P, Carpiniello B, Cuomo A, Dell'Osso L, Giordano GM, Marchesi C, Monteleone P, Niolu C, Oldani L, Pettorruso M, Pompili M, Roncone R, Rossi R, Tenconi E, Vita A, Zeppegno P, Maj M; Italian Network for Research on Psychoses. Mucci A, et al. Among authors: bertolino a. JAMA Psychiatry. 2021 May 1;78(5):550-559. doi: 10.1001/jamapsychiatry.2020.4614. JAMA Psychiatry. 2021. PMID: 33566071 Free PMC article.
Towards clinical application of prediction models for transition to psychosis: A systematic review and external validation study in the PRONIA sample.
Rosen M, Betz LT, Schultze-Lutter F, Chisholm K, Haidl TK, Kambeitz-Ilankovic L, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Ruhrmann S, Salokangas RKR, Upthegrove R, Wood SJ, Koutsouleris N, Kambeitz J; PRONIA Consortium. Rosen M, et al. Among authors: bertolino a. Neurosci Biobehav Rev. 2021 Jun;125:478-492. doi: 10.1016/j.neubiorev.2021.02.032. Epub 2021 Feb 23. Neurosci Biobehav Rev. 2021. PMID: 33636198 Review.
Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis.
Penzel N, Antonucci LA, Betz LT, Sanfelici R, Weiske J, Pogarell O, Cumming P, Quednow BB, Howes O, Falkai P, Upthegrove R, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Rosen M, Haidl T, Kambeitz-Ilankovic L, Ruhrmann S, Salokangas RRK, Pantelis C, Wood SJ, Koutsouleris N, Kambeitz J; PRONIA Consortium. Penzel N, et al. Among authors: bertolino a. Neuropsychopharmacology. 2021 Jul;46(8):1484-1493. doi: 10.1038/s41386-021-00977-9. Epub 2021 Mar 3. Neuropsychopharmacology. 2021. PMID: 33658653 Free PMC article.
Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?
Wenzel J, Haas SS, Dwyer DB, Ruef A, Oeztuerk OF, Antonucci LA, von Saldern S, Bonivento C, Garzitto M, Ferro A, Paolini M, Blautzik J, Borgwardt S, Brambilla P, Meisenzahl E, Salokangas RKR, Upthegrove R, Wood SJ, Kambeitz J, Koutsouleris N, Kambeitz-Ilankovic L; PRONIA consortium. Wenzel J, et al. Neuropsychopharmacology. 2021 Jul;46(8):1475-1483. doi: 10.1038/s41386-021-00963-1. Epub 2021 Mar 15. Neuropsychopharmacology. 2021. PMID: 33723384 Free PMC article.
Toward Generalizable and Transdiagnostic Tools for Psychosis Prediction: An Independent Validation and Improvement of the NAPLS-2 Risk Calculator in the Multisite PRONIA Cohort.
Koutsouleris N, Worthington M, Dwyer DB, Kambeitz-Ilankovic L, Sanfelici R, Fusar-Poli P, Rosen M, Ruhrmann S, Anticevic A, Addington J, Perkins DO, Bearden CE, Cornblatt BA, Cadenhead KS, Mathalon DH, McGlashan T, Seidman L, Tsuang M, Walker EF, Woods SW, Falkai P, Lencer R, Bertolino A, Kambeitz J, Schultze-Lutter F, Meisenzahl E, Salokangas RKR, Hietala J, Brambilla P, Upthegrove R, Borgwardt S, Wood S, Gur RE, McGuire P, Cannon TD. Koutsouleris N, et al. Among authors: bertolino a. Biol Psychiatry. 2021 Nov 1;90(9):632-642. doi: 10.1016/j.biopsych.2021.06.023. Epub 2021 Jul 6. Biol Psychiatry. 2021. PMID: 34482951 Free PMC article.
Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.
Sanfelici R, Ruef A, Antonucci LA, Penzel N, Sotiras A, Dong MS, Urquijo-Castro M, Wenzel J, Kambeitz-Ilankovic L, Hettwer MD, Ruhrmann S, Chisholm K, Riecher-Rössler A, Falkai P, Pantelis C, Salokangas RKR, Lencer R, Bertolino A, Kambeitz J, Meisenzahl E, Borgwardt S, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Koutsouleris N, Dwyer DB; PRONIA Consortium. Sanfelici R, et al. Among authors: bertolino a. Cereb Cortex. 2022 Apr 5;32(8):1625-1636. doi: 10.1093/cercor/bhab288. Cereb Cortex. 2022. PMID: 34519351 Free PMC article.
Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression.
Squarcina L, Kambeitz-Ilankovic L, Bonivento C, Prunas C, Oldani L, Wenzel J, Ruef A, Dwyer D, Ferro A, Borgwardt S, Kambeitz J, Lichtenstein TK, Meisenzahl E, Pantelis C, Rosen M, Upthegrove R, Antonucci LA, Bertolino A, Lencer R, Ruhrmann S, Salokangas RRK, Schultze-Lutter F, Chisholm K, Stainton A, Wood SJ, Koutsouleris N, Brambilla P; PRONIA consortium. Squarcina L, et al. Among authors: bertolino a. World J Biol Psychiatry. 2022 Oct;23(8):573-581. doi: 10.1080/15622975.2021.2014955. Epub 2022 Jan 20. World J Biol Psychiatry. 2022. PMID: 35048791
Detailed clinical phenotyping and generalisability in prognostic models of functioning in at-risk populations.
Rosen M, Betz LT, Kaiser N, Penzel N, Dwyer D, Lichtenstein TK, Schultze-Lutter F, Kambeitz-Ilankovic L, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Pantelis C, Salokangas RKR, Upthegrove R, Wood S, Ruhrmann S, Koutsouleris N, Kambeitz J; PRONIA consortium. Rosen M, et al. Among authors: bertolino a. Br J Psychiatry. 2021 Oct 6:1-4. doi: 10.1192/bjp.2021.141. Online ahead of print. Br J Psychiatry. 2021. PMID: 35049486
Using combined environmental-clinical classification models to predict role functioning outcome in clinical high-risk states for psychosis and recent-onset depression.
Antonucci LA, Penzel N, Sanfelici R, Pigoni A, Kambeitz-Ilankovic L, Dwyer D, Ruef A, Sen Dong M, Öztürk ÖF, Chisholm K, Haidl T, Rosen M, Ferro A, Pergola G, Andriola I, Blasi G, Ruhrmann S, Schultze-Lutter F, Falkai P, Kambeitz J, Lencer R, Dannlowski U, Upthegrove R, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Brambilla P, Borgwardt S, Bertolino A, Koutsouleris N; PRONIA Consortium. Antonucci LA, et al. Among authors: bertolino a. Br J Psychiatry. 2022 Feb 14:1-17. doi: 10.1192/bjp.2022.16. Online ahead of print. Br J Psychiatry. 2022. PMID: 35152923 Free article.
Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis.
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Virtual Ontogeny of Cortical Growth Preceding Mental Illness.
Patel Y, Shin J, Abé C, Agartz I, Alloza C, Alnæs D, Ambrogi S, Antonucci LA, Arango C, Arolt V, Auzias G, Ayesa-Arriola R, Banaj N, Banaschewski T, Bandeira C, Başgöze Z, Cupertino RB, Bau CHD, Bauer J, Baumeister S, Bernardoni F, Bertolino A, Bonnin CDM, Brandeis D, Brem S, Bruggemann J, Bülow R, Bustillo JR, Calderoni S, Calvo R, Canales-Rodríguez EJ, Cannon DM, Carmona S, Carr VJ, Catts SV, Chenji S, Chew QH, Coghill D, Connolly CG, Conzelmann A, Craven AR, Crespo-Facorro B, Cullen K, Dahl A, Dannlowski U, Davey CG, Deruelle C, Díaz-Caneja CM, Dohm K, Ehrlich S, Epstein J, Erwin-Grabner T, Eyler LT, Fedor J, Fitzgerald J, Foran W, Ford JM, Fortea L, Fuentes-Claramonte P, Fullerton J, Furlong L, Gallagher L, Gao B, Gao S, Goikolea JM, Gotlib I, Goya-Maldonado R, Grabe HJ, Green M, Grevet EH, Groenewold NA, Grotegerd D, Gruber O, Haavik J, Hahn T, Harrison BJ, Heindel W, Henskens F, Heslenfeld DJ, Hilland E, Hoekstra PJ, Hohmann S, Holz N, Howells FM, Ipser JC, Jahanshad N, Jakobi B, Jansen A, Janssen J, Jonassen R, Kaiser A, Kaleda V, Karantonis J, King JA, Kircher T, Kochunov P, Koopowitz SM, Landén M, Landrø NI, Lawrie S, Lebedeva I, Luna B, Lundervold AJ, MacMaster FP… See abstract for full author list ➔ Patel Y, et al. Among authors: bertolino a. Biol Psychiatry. 2022 Aug 15;92(4):299-313. doi: 10.1016/j.biopsych.2022.02.959. Epub 2022 Mar 4. Biol Psychiatry. 2022. PMID: 35489875 Free article.
Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages.
Dwyer DB, Buciuman MO, Ruef A, Kambeitz J, Sen Dong M, Stinson C, Kambeitz-Ilankovic L, Degenhardt F, Sanfelici R, Antonucci LA, Lalousis PA, Wenzel J, Urquijo-Castro MF, Popovic D, Oeztuerk OF, Haas SS, Weiske J, Hauke D, Neufang S, Schmidt-Kraepelin C, Ruhrmann S, Penzel N, Lichtenstein T, Rosen M, Chisholm K, Riecher-Rössler A, Egloff L, Schmidt A, Andreou C, Hietala J, Schirmer T, Romer G, Michel C, Rössler W, Maj C, Borisov O, Krawitz PM, Falkai P, Pantelis C, Lencer R, Bertolino A, Borgwardt S, Noethen M, Brambilla P, Schultze-Lutter F, Meisenzahl E, Wood SJ, Davatzikos C, Upthegrove R, Salokangas RKR, Koutsouleris N; PRONIA Consortium. Dwyer DB, et al. Among authors: bertolino a. JAMA Psychiatry. 2022 Jul 1;79(7):677-689. doi: 10.1001/jamapsychiatry.2022.1163. JAMA Psychiatry. 2022. PMID: 35583903 Free PMC article.
Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes.
Lalousis PA, Schmaal L, Wood SJ, Reniers RLEP, Barnes NM, Chisholm K, Griffiths SL, Stainton A, Wen J, Hwang G, Davatzikos C, Wenzel J, Kambeitz-Ilankovic L, Andreou C, Bonivento C, Dannlowski U, Ferro A, Lichtenstein T, Riecher-Rössler A, Romer G, Rosen M, Bertolino A, Borgwardt S, Brambilla P, Kambeitz J, Lencer R, Pantelis C, Ruhrmann S, Salokangas RKR, Schultze-Lutter F, Schmidt A, Meisenzahl E, Koutsouleris N, Dwyer D, Upthegrove R; PRONIA Consortium. Lalousis PA, et al. Among authors: bertolino a. Biol Psychiatry. 2022 Oct 1;92(7):552-562. doi: 10.1016/j.biopsych.2022.03.021. Epub 2022 Apr 12. Biol Psychiatry. 2022. PMID: 35717212 Free PMC article.
Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited.
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The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis.
Schwarzer JM, Meyhoefer I, Antonucci LA, Kambeitz-Ilankovic L, Surmann M, Bienek O, Romer G, Dannlowski U, Hahn T, Korda A, Dwyer DB, Ruef A, Haas SS, Rosen M, Lichtenstein T, Ruhrmann S, Kambeitz J, Salokangas RKR, Pantelis C, Schultze-Lutter F, Meisenzahl E, Brambilla P, Bertolino A, Borgwardt S, Upthegrove R, Koutsouleris N, Lencer R; PRONIA Consortium. Schwarzer JM, et al. Among authors: bertolino a. Neuropsychopharmacology. 2022 Nov;47(12):2051-2060. doi: 10.1038/s41386-022-01385-3. Epub 2022 Aug 18. Neuropsychopharmacology. 2022. PMID: 35982238 Free PMC article.
Clinical and psychological factors associated with resilience in patients with schizophrenia: data from the Italian network for research on psychoses using machine learning.
Antonucci LA, Pergola G, Rampino A, Rocca P, Rossi A, Amore M, Aguglia E, Bellomo A, Bianchini V, Brasso C, Bucci P, Carpiniello B, Dell'Osso L, di Fabio F, di Giannantonio M, Fagiolini A, Giordano GM, Marcatilli M, Marchesi C, Meneguzzo P, Monteleone P, Pompili M, Rossi R, Siracusano A, Vita A, Zeppegno P, Galderisi S, Bertolino A, Maj M; Italian Network for Research on Psychoses. Antonucci LA, et al. Among authors: bertolino a. Psychol Med. 2023 Sep;53(12):5717-5728. doi: 10.1017/S003329172200294X. Epub 2022 Oct 11. Psychol Med. 2023. PMID: 36217912
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
Schijven D, Postema MC, Fukunaga M, Matsumoto J, Miura K, de Zwarte SMC, van Haren NEM, Cahn W, Hulshoff Pol HE, Kahn RS, Ayesa-Arriola R, Ortiz-García de la Foz V, Tordesillas-Gutierrez D, Vázquez-Bourgon J, Crespo-Facorro B, Alnæs D, Dahl A, Westlye LT, Agartz I, Andreassen OA, Jönsson EG, Kochunov P, Bruggemann JM, Catts SV, Michie PT, Mowry BJ, Quidé Y, Rasser PE, Schall U, Scott RJ, Carr VJ, Green MJ, Henskens FA, Loughland CM, Pantelis C, Weickert CS, Weickert TW, de Haan L, Brosch K, Pfarr JK, Ringwald KG, Stein F, Jansen A, Kircher TTJ, Nenadić I, Krämer B, Gruber O, Satterthwaite TD, Bustillo J, Mathalon DH, Preda A, Calhoun VD, Ford JM, Potkin SG, Chen J, Tan Y, Wang Z, Xiang H, Fan F, Bernardoni F, Ehrlich S, Fuentes-Claramonte P, Garcia-Leon MA, Guerrero-Pedraza A, Salvador R, Sarró S, Pomarol-Clotet E, Ciullo V, Piras F, Vecchio D, Banaj N, Spalletta G, Michielse S, van Amelsvoort T, Dickie EW, Voineskos AN, Sim K, Ciufolini S, Dazzan P, Murray RM, Kim WS, Chung YC, Andreou C, Schmidt A, Borgwardt S, McIntosh AM, Whalley HC, Lawrie SM, du Plessis S, Luckhoff HK, Scheffler F, Emsley R, Grotegerd D, Lencer R, Dannlowski U, Edmond JT, Rootes-Murdy K, Stephen JM, Mayer AR… See abstract for full author list ➔ Schijven D, et al. Among authors: bertolino a. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2213880120. doi: 10.1073/pnas.2213880120. Epub 2023 Mar 28. Proc Natl Acad Sci U S A. 2023. PMID: 36976765 Free PMC article.
Changes in patterns of age-related network connectivity are associated with risk for schizophrenia.
Passiatore R, Antonucci LA, DeRamus TP, Fazio L, Stolfa G, Sportelli L, Kikidis GC, Blasi G, Chen Q, Dukart J, Goldman AL, Mattay VS, Popolizio T, Rampino A, Sambataro F, Selvaggi P, Ulrich W; Apulian Network on Risk for Psychosis; Weinberger DR, Bertolino A, Calhoun VD, Pergola G. Passiatore R, et al. Among authors: bertolino a. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2221533120. doi: 10.1073/pnas.2221533120. Epub 2023 Aug 1. Proc Natl Acad Sci U S A. 2023. PMID: 37527347 Free PMC article.
The interaction between early life complications and a polygenic risk score for schizophrenia is associated with brain activity during emotion processing in healthy participants.
Toro VD, Antonucci LA, Quarto T, Passiatore R, Fazio L, Ursini G, Chen Q, Masellis R, Torretta S, Sportelli L, Kikidis GC, Massari F, D'Ambrosio E, Rampino A, Pergola G, Weinberger DR, Bertolino A, Blasi G. Toro VD, et al. Among authors: bertolino a. Psychol Med. 2024 Feb 2:1-10. doi: 10.1017/S0033291724000011. Online ahead of print. Psychol Med. 2024. PMID: 38305128
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT.
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Changes in prefrontal and amygdala activity during olanzapine treatment in schizophrenia.
Blasi G, Popolizio T, Taurisano P, Caforio G, Romano R, Di Giorgio A, Sambataro F, Rubino V, Latorre V, Lo Bianco L, Fazio L, Nardini M, Weinberger DR, Bertolino A. Blasi G, et al. Among authors: bertolino a. Psychiatry Res. 2009 Jul 15;173(1):31-8. doi: 10.1016/j.pscychresns.2008.09.001. Epub 2009 May 9. Psychiatry Res. 2009. PMID: 19428222 Free PMC article.
Association of GSK-3β genetic variation with GSK-3β expression, prefrontal cortical thickness, prefrontal physiology, and schizophrenia.
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Prefronto-striatal physiology is associated with schizotypy and is modulated by a functional variant of DRD2.
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Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics.
Blasi G, Selvaggi P, Fazio L, Antonucci LA, Taurisano P, Masellis R, Romano R, Mancini M, Zhang F, Caforio G, Popolizio T, Apud J, Weinberger DR, Bertolino A. Blasi G, et al. Among authors: bertolino a. Neuropsychopharmacology. 2015 Jun;40(7):1600-8. doi: 10.1038/npp.2015.5. Epub 2015 Jan 7. Neuropsychopharmacology. 2015. PMID: 25563748 Free PMC article.
Prefrontal activity during working memory is modulated by the interaction of variation in CB1 and COX2 coding genes and correlates with frequency of cannabis use.
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Prefrontal Activity and Connectivity with the Basal Ganglia during Performance of Complex Cognitive Tasks Is Associated with Apathy in Healthy Subjects.
Fazio L, Logroscino G, Taurisano P, Amico G, Quarto T, Antonucci LA, Barulli MR, Mancini M, Gelao B, Ferranti L, Popolizio T, Bertolino A, Blasi G. Fazio L, et al. Among authors: bertolino a. PLoS One. 2016 Oct 31;11(10):e0165301. doi: 10.1371/journal.pone.0165301. eCollection 2016. PLoS One. 2016. PMID: 27798669 Free PMC article.
Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls.
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A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans.
Rampino A, Taurisano P, Fanelli G, Attrotto M, Torretta S, Antonucci LA, Miccolis G, Pergola G, Ursini G, Maddalena G, Romano R, Masellis R, Di Carlo P, Pignataro P, Blasi G, Bertolino A. Rampino A, et al. Among authors: bertolino a. Eur Neuropsychopharmacol. 2017 Sep;27(9):928-939. doi: 10.1016/j.euroneuro.2017.06.005. Epub 2017 Jun 23. Eur Neuropsychopharmacol. 2017. PMID: 28651857
Personal resources and depression in schizophrenia: The role of self-esteem, resilience and internalized stigma.
Rossi A, Galderisi S, Rocca P, Bertolino A, Rucci P, Gibertoni D, Stratta P, Bucci P, Mucci A, Aguglia E, Amodeo G, Amore M, Bellomo A, Brugnoli R, Caforio G, Carpiniello B, Dell'Osso L, di Fabio F, di Giannantonio M, Marchesi C, Monteleone P, Montemagni C, Oldani L, Roncone R, Sacchetti E, Santonastaso P, Siracusano A, Zeppegno P, Maj M; Italian Network for Research on Psychoses. Rossi A, et al. Among authors: bertolino a. Psychiatry Res. 2017 Oct;256:359-364. doi: 10.1016/j.psychres.2017.06.079. Epub 2017 Jun 27. Psychiatry Res. 2017. PMID: 28686933 Free article.
Metabolic-inflammatory status as predictor of clinical outcome at 1-year follow-up in patients with first episode psychosis.
Nettis MA, Pergola G, Kolliakou A, O'Connor J, Bonaccorso S, David A, Gaughran F, Di Forti M, Murray RM, Marques TR, Blasi G, Bertolino A, Pariante CM, Dazzan P, Mondelli V. Nettis MA, et al. Among authors: bertolino a. Psychoneuroendocrinology. 2019 Jan;99:145-153. doi: 10.1016/j.psyneuen.2018.09.005. Epub 2018 Sep 8. Psychoneuroendocrinology. 2019. PMID: 30243054
The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.
de Zwarte SMC, Brouwer RM, Agartz I, Alda M, Aleman A, Alpert KI, Bearden CE, Bertolino A, Bois C, Bonvino A, Bramon E, Buimer EEL, Cahn W, Cannon DM, Cannon TD, Caseras X, Castro-Fornieles J, Chen Q, Chung Y, De la Serna E, Di Giorgio A, Doucet GE, Eker MC, Erk S, Fears SC, Foley SF, Frangou S, Frankland A, Fullerton JM, Glahn DC, Goghari VM, Goldman AL, Gonul AS, Gruber O, de Haan L, Hajek T, Hawkins EL, Heinz A, Hillegers MHJ, Hulshoff Pol HE, Hultman CM, Ingvar M, Johansson V, Jönsson EG, Kane F, Kempton MJ, Koenis MMG, Kopecek M, Krabbendam L, Krämer B, Lawrie SM, Lenroot RK, Marcelis M, Marsman JC, Mattay VS, McDonald C, Meyer-Lindenberg A, Michielse S, Mitchell PB, Moreno D, Murray RM, Mwangi B, Najt P, Neilson E, Newport J, van Os J, Overs B, Ozerdem A, Picchioni MM, Richter A, Roberts G, Aydogan AS, Schofield PR, Simsek F, Soares JC, Sugranyes G, Toulopoulou T, Tronchin G, Walter H, Wang L, Weinberger DR, Whalley HC, Yalin N, Andreassen OA, Ching CRK, van Erp TGM, Turner JA, Jahanshad N, Thompson PM, Kahn RS, van Haren NEM. de Zwarte SMC, et al. Among authors: bertolino a. Biol Psychiatry. 2019 Oct 1;86(7):545-556. doi: 10.1016/j.biopsych.2019.03.985. Epub 2019 Jun 13. Biol Psychiatry. 2019. PMID: 31443932 Free PMC article.
The interaction between cannabis use and a CB1-related polygenic co-expression index modulates dorsolateral prefrontal activity during working memory processing.
Taurisano P, Pergola G, Monda A, Antonucci LA, Di Carlo P, Piarulli F, Passiatore R, Papalino M, Romano R, Monaco A, Rampino A, Bonvino A, Porcelli A, Popolizio T, Bellotti R, Bertolino A, Blasi G. Taurisano P, et al. Among authors: bertolino a. Brain Imaging Behav. 2021 Feb;15(1):288-299. doi: 10.1007/s11682-020-00256-z. Brain Imaging Behav. 2021. PMID: 32124274
Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA.
Radua J, Vieta E, Shinohara R, Kochunov P, Quidé Y, Green MJ, Weickert CS, Weickert T, Bruggemann J, Kircher T, Nenadić I, Cairns MJ, Seal M, Schall U, Henskens F, Fullerton JM, Mowry B, Pantelis C, Lenroot R, Cropley V, Loughland C, Scott R, Wolf D, Satterthwaite TD, Tan Y, Sim K, Piras F, Spalletta G, Banaj N, Pomarol-Clotet E, Solanes A, Albajes-Eizagirre A, Canales-Rodríguez EJ, Sarro S, Di Giorgio A, Bertolino A, Stäblein M, Oertel V, Knöchel C, Borgwardt S, du Plessis S, Yun JY, Kwon JS, Dannlowski U, Hahn T, Grotegerd D, Alloza C, Arango C, Janssen J, Díaz-Caneja C, Jiang W, Calhoun V, Ehrlich S, Yang K, Cascella NG, Takayanagi Y, Sawa A, Tomyshev A, Lebedeva I, Kaleda V, Kirschner M, Hoschl C, Tomecek D, Skoch A, van Amelsvoort T, Bakker G, James A, Preda A, Weideman A, Stein DJ, Howells F, Uhlmann A, Temmingh H, López-Jaramillo C, Díaz-Zuluaga A, Fortea L, Martinez-Heras E, Solana E, Llufriu S, Jahanshad N, Thompson P, Turner J, van Erp T; ENIGMA Consortium collaborators. Radua J, et al. Among authors: bertolino a. Neuroimage. 2020 Sep;218:116956. doi: 10.1016/j.neuroimage.2020.116956. Epub 2020 May 26. Neuroimage. 2020. PMID: 32470572 Free PMC article.
Which factors delay treatment in bipolar disorder? A nationwide study focussed on duration of untreated illness.
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The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study.
Vita A, Barlati S, Deste G, Rocca P, Rossi A, Bertolino A, Aguglia E, Amore M, Bellomo A, Biondi M, Carpiniello B, Collantoni E, Cuomo A, D'Ambrosio E, Dell' Osso L, di Giannantonio M, Giordano GM, Marchesi C, Monteleone P, Montemagni C, Oldani L, Pompili M, Roncone R, Rossi R, Siracusano A, Zeppegno P, Nibbio G, Galderisi S, Maj M; Italian Network for Research on Psychoses. Vita A, et al. Among authors: bertolino a. Eur Psychiatry. 2020 Nov 10;63(1):e98. doi: 10.1192/j.eurpsy.2020.99. Eur Psychiatry. 2020. PMID: 33168115 Free PMC article.
Factors associated with lifetime suicide attempts in bipolar disorder: results from an Italian nationwide study.
Buoli M, Cesana BM, Bolognesi S, Fagiolini A, Albert U, Di Salvo G, Maina G, de Bartolomeis A, Pompili M, Palumbo C, Bondi E, Steardo L Jr, De Fazio P, Amore M, Altamura M, Bellomo A, Bertolino A, Di Nicola M, Di Sciascio G, Fiorillo A, Sacchetti E, Sani G, Siracusano A, Di Lorenzo G, Tortorella A, Altamura AC, Dell'Osso B; ISBD Italian Chapter Epidemiologic Group. Buoli M, et al. Among authors: bertolino a. Eur Arch Psychiatry Clin Neurosci. 2022 Apr;272(3):359-370. doi: 10.1007/s00406-021-01343-y. Epub 2021 Oct 15. Eur Arch Psychiatry Clin Neurosci. 2022. PMID: 34652488 Free PMC article.
Joint structural-functional magnetic resonance imaging features are associated with diagnosis and real-world functioning in patients with schizophrenia.
Antonucci LA, Fazio L, Pergola G, Blasi G, Stolfa G, Di Palo P, Mucci A, Rocca P, Brasso C, di Giannantonio M, Maria Giordano G, Monteleone P, Pompili M, Siracusano A, Bertolino A, Galderisi S, Maj M; Italian Network for Research on Psychoses. Antonucci LA, et al. Among authors: bertolino a. Schizophr Res. 2022 Feb;240:193-203. doi: 10.1016/j.schres.2021.12.029. Epub 2022 Jan 12. Schizophr Res. 2022. PMID: 35032904
Preferential amygdala reactivity to the negative assessment of neutral faces.
Blasi G, Hariri AR, Alce G, Taurisano P, Sambataro F, Das S, Bertolino A, Weinberger DR, Mattay VS. Blasi G, et al. Among authors: bertolino a. Biol Psychiatry. 2009 Nov 1;66(9):847-53. doi: 10.1016/j.biopsych.2009.06.017. Epub 2009 Aug 26. Biol Psychiatry. 2009. PMID: 19709644 Free PMC article.
Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis.
Colizzi M, Iyegbe C, Powell J, Ursini G, Porcelli A, Bonvino A, Taurisano P, Romano R, Masellis R, Blasi G, Morgan C, Aitchison K, Mondelli V, Luzi S, Kolliakou A, David A, Murray RM, Bertolino A, Di Forti M. Colizzi M, et al. Among authors: bertolino a. Schizophr Bull. 2015 Sep;41(5):1171-82. doi: 10.1093/schbul/sbv032. Epub 2015 Mar 31. Schizophr Bull. 2015. PMID: 25829376 Free PMC article.
Ankyrin-3 as a molecular marker of early-life stress and vulnerability to psychiatric disorders.
Luoni A, Massart R, Nieratschker V, Nemoda Z, Blasi G, Gilles M, Witt SH, Suderman MJ, Suomi SJ, Porcelli A, Rizzo G, Fazio L, Torretta S, Rampino A, Berry A, Gass P, Cirulli F, Rietschel M, Bertolino A, Deuschle M, Szyf M, Riva MA. Luoni A, et al. Among authors: bertolino a. Transl Psychiatry. 2016 Nov 8;6(11):e943. doi: 10.1038/tp.2016.211. Transl Psychiatry. 2016. PMID: 27824361 Free PMC article.
DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia.
Pergola G, Di Carlo P, D'Ambrosio E, Gelao B, Fazio L, Papalino M, Monda A, Scozia G, Pietrangelo B, Attrotto M, Apud JA, Chen Q, Mattay VS, Rampino A, Caforio G, Weinberger DR, Blasi G, Bertolino A. Pergola G, et al. Among authors: bertolino a. Transl Psychiatry. 2017 Jan 17;7(1):e1006. doi: 10.1038/tp.2016.253. Transl Psychiatry. 2017. PMID: 28094815 Free PMC article.
Genetic control of variability in subcortical and intracranial volumes.
Córdova-Palomera A, van der Meer D, Kaufmann T, Bettella F, Wang Y, Alnæs D, Doan NT, Agartz I, Bertolino A, Buitelaar JK, Coynel D, Djurovic S, Dørum ES, Espeseth T, Fazio L, Franke B, Frei O, Håberg A, Le Hellard S, Jönsson EG, Kolskår KK, Lund MJ, Moberget T, Nordvik JE, Nyberg L, Papassotiropoulos A, Pergola G, de Quervain D, Rampino A, Richard G, Rokicki J, Sanders AM, Schwarz E, Smeland OB, Steen VM, Starrfelt J, Sønderby IE, Ulrichsen KM, Andreassen OA, Westlye LT. Córdova-Palomera A, et al. Among authors: bertolino a. Mol Psychiatry. 2021 Aug;26(8):3876-3883. doi: 10.1038/s41380-020-0664-1. Epub 2020 Feb 11. Mol Psychiatry. 2021. PMID: 32047264
Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.
de Zwarte SMC, Brouwer RM, Agartz I, Alda M, Alonso-Lana S, Bearden CE, Bertolino A, Bonvino A, Bramon E, Buimer EEL, Cahn W, Canales-Rodríguez EJ, Cannon DM, Cannon TD, Caseras X, Castro-Fornieles J, Chen Q, Chung Y, De la Serna E, Del Mar Bonnin C, Demro C, Di Giorgio A, Doucet GE, Eker MC, Erk S, Fatjó-Vilas M, Fears SC, Foley SF, Frangou S, Fullerton JM, Glahn DC, Goghari VM, Goikolea JM, Goldman AL, Gonul AS, Gruber O, Hajek T, Hawkins EL, Heinz A, Hidiroglu Ongun C, Hillegers MHJ, Houenou J, Hulshoff Pol HE, Hultman CM, Ingvar M, Johansson V, Jönsson EG, Kane F, Kempton MJ, Koenis MMG, Kopecek M, Krämer B, Lawrie SM, Lenroot RK, Marcelis M, Mattay VS, McDonald C, Meyer-Lindenberg A, Michielse S, Mitchell PB, Moreno D, Murray RM, Mwangi B, Nabulsi L, Newport J, Olman CA, van Os J, Overs BJ, Ozerdem A, Pergola G, Picchioni MM, Piguet C, Pomarol-Clotet E, Radua J, Ramsay IS, Richter A, Roberts G, Salvador R, Saricicek Aydogan A, Sarró S, Schofield PR, Simsek EM, Simsek F, Soares JC, Sponheim SR, Sugranyes G, Toulopoulou T, Tronchin G, Vieta E, Walter H, Weinberger DR, Whalley HC, Wu MJ, Yalin N, Andreassen OA, Ching CRK, Thomopoulos SI, van Erp TGM, Jahanshad N, Thompson… See abstract for full author list ➔ de Zwarte SMC, et al. Among authors: bertolino a. Hum Brain Mapp. 2022 Jan;43(1):414-430. doi: 10.1002/hbm.25206. Epub 2020 Oct 7. Hum Brain Mapp. 2022. PMID: 33027543 Free PMC article.
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Koopmans F, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo MH, Bacanu SA, Bass NJ, Begemann M, Belliveau RA, Bene J, Benyamin B, Bergen SE, Blasi G, Bobes J, Bonassi S, Braun A, Bressan RA, Bromet EJ, Bruggeman R, Buckley PF, Buckner RL, Bybjerg-Grauholm J, Cahn W, Cairns MJ, Calkins ME, Carr VJ, Castle D, Catts SV, Chambert KD, Chan RCK, Chaumette B, Cheng W, Cheung EFC, Chong SA, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis KL, de Haan L, Degenhardt F, DeLisi LE, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson JG, Fañanás L, Faraone SV, Fiorentino A, Forstner A, Frank J, Freimer NB, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon ES, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, González Peñas J, González-Pinto A, … See abstract for full author list ➔ Trubetskoy V, et al. Among authors: bertolino a. Nature. 2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. Epub 2022 Apr 8. Nature. 2022. PMID: 35396580 Free PMC article.
The Complex Interplay Between Physical Activity and Recovery Styles in Patients With Severe Mental Disorders in a Real-World Multicentric Study.
Sampogna G, Luciano M, Di Vincenzo M, Andriola I, D'Ambrosio E, Amore M, Serafini G, Rossi A, Carmassi C, Dell'Osso L, Di Lorenzo G, Siracusano A, Rossi R, Fiorillo A; Working Group LIFESTYLE. Sampogna G, et al. Front Psychiatry. 2022 Jul 11;13:945650. doi: 10.3389/fpsyt.2022.945650. eCollection 2022. Front Psychiatry. 2022. PMID: 35898630 Free PMC article.
Improving physical activity and diet in patients with severe mental disorders: Results from the LIFESTYLE multicentric, real-world randomized controlled trial.
Luciano M, Sampogna G, Amore M, Bertolino A, Dell'Osso L, Rossi A, Siracusano A, Calcagno P, Carmassi C, Di Lorenzo G, Di Vincenzo M, Giallonardo V, Rampino A, Rossi R; LIFESTYLE Working Group; Fiorillo A. Luciano M, et al. Among authors: bertolino a. Psychiatry Res. 2022 Nov;317:114818. doi: 10.1016/j.psychres.2022.114818. Epub 2022 Aug 31. Psychiatry Res. 2022. PMID: 36088834 Free article. Clinical Trial.
A miR-137-Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing.
Pergola G, Rampino A, Sportelli L, Borcuk CJ, Passiatore R, Di Carlo P, Marakhovskaia A, Fazio L, Amoroso N, Castro MN, Domenici E, Gennarelli M, Khlghatyan J, Kikidis GC, Lella A, Magri C, Monaco A, Papalino M, Parihar M, Popolizio T, Quarto T, Romano R, Torretta S, Valsecchi P, Zunuer H, Blasi G, Dukart J, Beaulieu JM, Bertolino A. Pergola G, et al. Among authors: bertolino a. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Mar;9(3):356-366. doi: 10.1016/j.bpsc.2023.11.001. Epub 2023 Nov 22. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024. PMID: 38000716 Free article.
Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.
Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR, Nardini M. Bertolino A, et al. Am J Psychiatry. 2004 Oct;161(10):1798-805. doi: 10.1176/ajp.161.10.1798. Am J Psychiatry. 2004. PMID: 15465976 Clinical Trial.
Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks.
Bertolino A, Di Giorgio A, Blasi G, Sambataro F, Caforio G, Sinibaldi L, Latorre V, Rampino A, Taurisano P, Fazio L, Romano R, Douzgou S, Popolizio T, Kolachana B, Nardini M, Weinberger DR, Dallapiccola B. Bertolino A, et al. Biol Psychiatry. 2008 Aug 1;64(3):226-34. doi: 10.1016/j.biopsych.2008.02.001. Epub 2008 Mar 28. Biol Psychiatry. 2008. PMID: 18374902
Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia.
Sambataro F, Blasi G, Fazio L, Caforio G, Taurisano P, Romano R, Di Giorgio A, Gelao B, Lo Bianco L, Papazacharias A, Popolizio T, Nardini M, Bertolino A. Sambataro F, et al. Among authors: bertolino a. Neuropsychopharmacology. 2010 Mar;35(4):904-12. doi: 10.1038/npp.2009.192. Epub 2009 Dec 2. Neuropsychopharmacology. 2010. PMID: 19956088 Free PMC article. Clinical Trial.
Catechol-O-methyltransferase Val(158)Met association with parahippocampal physiology during memory encoding in schizophrenia.
Di Giorgio A, Caforio G, Blasi G, Taurisano P, Fazio L, Romano R, Ursini G, Gelao B, Bianco LL, Papazacharias A, Sinibaldi L, Popolizio T, Bellomo A, Bertolino A. Di Giorgio A, et al. Among authors: bertolino a. Psychol Med. 2011 Aug;41(8):1721-31. doi: 10.1017/S0033291710002278. Epub 2010 Dec 13. Psychol Med. 2011. PMID: 21144115
Load-dependent dysfunction of the putamen during attentional processing in patients with clinically isolated syndrome suggestive of multiple sclerosis.
Tortorella C, Romano R, Direnzo V, Taurisano P, Zoccolella S, Iaffaldano P, Fazio L, Viterbo R, Popolizio T, Blasi G, Bertolino A, Trojano M. Tortorella C, et al. Among authors: bertolino a. Mult Scler. 2013 Aug;19(9):1153-60. doi: 10.1177/1352458512473671. Epub 2013 Jan 17. Mult Scler. 2013. PMID: 23329700
A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice.
Errico F, D'Argenio V, Sforazzini F, Iasevoli F, Squillace M, Guerri G, Napolitano F, Angrisano T, Di Maio A, Keller S, Vitucci D, Galbusera A, Chiariotti L, Bertolino A, de Bartolomeis A, Salvatore F, Gozzi A, Usiello A. Errico F, et al. Among authors: bertolino a. Transl Psychiatry. 2015 Feb 17;5(2):e512. doi: 10.1038/tp.2015.2. Transl Psychiatry. 2015. PMID: 25689573 Free PMC article.
The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study.
Rossi A, Galderisi S, Rocca P, Bertolino A, Mucci A, Rucci P, Gibertoni D, Aguglia E, Amore M, Andriola I, Bellomo A, Biondi M, Callista G, Comparelli A, Dell'Osso L, Di Giannantonio M, Fagiolini A, Marchesi C, Monteleone P, Montemagni C, Niolu C, Piegari G, Pinna F, Roncone R, Stratta P, Tenconi E, Vita A, Zeppegno P, Maj M; Italian Network for Research on Psychoses. Rossi A, et al. Among authors: bertolino a. Eur Arch Psychiatry Clin Neurosci. 2017 Jun;267(4):285-294. doi: 10.1007/s00406-016-0710-9. Epub 2016 Jul 6. Eur Arch Psychiatry Clin Neurosci. 2017. PMID: 27381016 Free article.
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.
van der Meer D, Rokicki J, Kaufmann T, Córdova-Palomera A, Moberget T, Alnæs D, Bettella F, Frei O, Doan NT, Sønderby IE, Smeland OB, Agartz I, Bertolino A, Bralten J, Brandt CL, Buitelaar JK, Djurovic S, van Donkelaar M, Dørum ES, Espeseth T, Faraone SV, Fernández G, Fisher SE, Franke B, Haatveit B, Hartman CA, Hoekstra PJ, Håberg AK, Jönsson EG, Kolskår KK, Le Hellard S, Lund MJ, Lundervold AJ, Lundervold A, Melle I, Monereo Sánchez J, Norbom LC, Nordvik JE, Nyberg L, Oosterlaan J, Papalino M, Papassotiropoulos A, Pergola G, de Quervain DJF, Richard G, Sanders AM, Selvaggi P, Shumskaya E, Steen VM, Tønnesen S, Ulrichsen KM, Zwiers MP, Andreassen OA, Westlye LT; Alzheimer’s Disease Neuroimaging Initiative; Pediatric Imaging, Neurocognition and Genetics Study. van der Meer D, et al. Among authors: bertolino a. Mol Psychiatry. 2020 Nov;25(11):3053-3065. doi: 10.1038/s41380-018-0262-7. Epub 2018 Oct 2. Mol Psychiatry. 2020. PMID: 30279459 Free PMC article.
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.
Frangou S, Modabbernia A, Williams SCR, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI, Andersson M, Andreasen NC, Andreassen OA, Asherson P, Banaschewski T, Bargallo N, Baumeister S, Baur-Streubel R, Bertolino A, Bonvino A, Boomsma DI, Borgwardt S, Bourque J, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buitelaar JK, Busatto GF, Buckner RL, Calhoun V, Canales-Rodríguez EJ, Cannon DM, Caseras X, Castellanos FX, Cervenka S, Chaim-Avancini TM, Ching CRK, Chubar V, Clark VP, Conrod P, Conzelmann A, Crespo-Facorro B, Crivello F, Crone EA, Dale AM, Dannlowski U, Davey C, de Geus EJC, de Haan L, de Zubicaray GI, den Braber A, Dickie EW, Di Giorgio A, Doan NT, Dørum ES, Ehrlich S, Erk S, Espeseth T, Fatouros-Bergman H, Fisher SE, Fouche JP, Franke B, Frodl T, Fuentes-Claramonte P, Glahn DC, Gotlib IH, Grabe HJ, Grimm O, Groenewold NA, Grotegerd D, Gruber O, Gruner P, Gur RE, Gur RC, Hahn T, Harrison BJ, Hartman CA, Hatton SN, Heinz A, Heslenfeld DJ, Hibar DP, Hickie IB, Ho BC, Hoekstra PJ, Hohmann S, Holmes AJ, Hoogman M, Hosten N, Howells FM, Hulshoff Pol HE, Huyser C, Jahanshad N, James A, Jernigan TL, Jiang J, Jönsson EG, … See abstract for full author list ➔ Frangou S, et al. Among authors: bertolino a. Hum Brain Mapp. 2022 Jan;43(1):431-451. doi: 10.1002/hbm.25364. Epub 2021 Feb 17. Hum Brain Mapp. 2022. PMID: 33595143 Free PMC article.
Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing.
Quarto T, Paparella I, De Tullio D, Viscanti G, Fazio L, Taurisano P, Romano R, Rampino A, Masellis R, Popolizio T, Selvaggi P, Pergola G, Bertolino A, Blasi G. Quarto T, et al. Among authors: bertolino a. Schizophr Bull. 2018 Jun 6;44(4):834-843. doi: 10.1093/schbul/sbx128. Schizophr Bull. 2018. PMID: 28981847 Free PMC article.
Patients with autism spectrum disorders display reproducible functional connectivity alterations.
Holiga Š, Hipp JF, Chatham CH, Garces P, Spooren W, D'Ardhuy XL, Bertolino A, Bouquet C, Buitelaar JK, Bours C, Rausch A, Oldehinkel M, Bouvard M, Amestoy A, Caralp M, Gueguen S, Ly-Le Moal M, Houenou J, Beckmann CF, Loth E, Murphy D, Charman T, Tillmann J, Laidi C, Delorme R, Beggiato A, Gaman A, Scheid I, Leboyer M, d'Albis MA, Sevigny J, Czech C, Bolognani F, Honey GD, Dukart J. Holiga Š, et al. Among authors: bertolino a. Sci Transl Med. 2019 Feb 27;11(481):eaat9223. doi: 10.1126/scitranslmed.aat9223. Sci Transl Med. 2019. PMID: 30814340
Evidence of an interaction between FXR1 and GSK3β polymorphisms on levels of Negative Symptoms of Schizophrenia and their response to antipsychotics.
Rampino A, Torretta S, Gelao B, Veneziani F, Iacoviello M, Marakhovskaya A, Masellis R, Andriola I, Sportelli L, Pergola G, Minelli A, Magri C, Gennarelli M, Vita A, Beaulieu JM, Bertolino A, Blasi G. Rampino A, et al. Among authors: bertolino a. Eur Psychiatry. 2021 Apr 19;64(1):e39. doi: 10.1192/j.eurpsy.2021.26. Eur Psychiatry. 2021. PMID: 33866994 Free PMC article.
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