Gherardini J - Search Results

1

Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy.

Gherardini J, Samra T, Gomez-Gomez T, Akhundlu A, Verling SD, Linowiecka K, Wikramanayake TC, Knie U, Rodríguez-Feliz J, Kassir R, Funk W, Azar RP, Annis DA, Aivado M, Chéret J, Paus R. Gherardini J, et al. J Clin Invest. 2026 May 1;136(9):e174447. doi: 10.1172/JCI174447. eCollection 2026 May 1. J Clin Invest. 2026. PMID: 42065249 Free PMC article.

2

Mitochondrially localized MPZL3 in the inner root sheath contributes to the regulation of human hair follicle cycling.

Suzuki T, Akhundlu A, Gherardini J, Hernández-Cuervo H, Bauman A, Kuka-Epstein G, Poloso N, Geyfman M, Wikramanayake TC, Chéret J, Paus R. Suzuki T, et al. Among authors: gherardini j. J Invest Dermatol. 2026 Jul;146(7):2021-2025.e5. doi: 10.1016/j.jid.2026.01.027. Epub 2026 Feb 10. J Invest Dermatol. 2026. PMID: 41672273 No abstract available.

3

Substance P Expands Proinflammatory, IL-31-Secreting M2 Macrophages in Human Skin Ex Vivo through Neurokinin-1 Receptor-Mediated Signaling and Increased Dermal Periostin Expression.

Perez SM, Gherardini J, Vattigunta M, Gomez TG, Lee W, Nattkemper L, Yosipovitch G, Chéret J, Paus R. Perez SM, et al. Among authors: gherardini j. J Invest Dermatol. 2026 Apr;146(4):1149-1153.e6. doi: 10.1016/j.jid.2025.09.377. Epub 2025 Oct 14. J Invest Dermatol. 2026. PMID: 41101631 No abstract available.

4

IL-15 Promotes the Survival of Anti-Inflammatory (M2), Immunoinhibitory (IL-10+) Dermal Macrophages in Human Eyelid Skin Under IFNγ-Dominated Inflammatory Conditions.

Demetrius DL, Perez SM, Suzuki T, Gherardini J, Lee W, Chéret J, Paus R. Demetrius DL, et al. Among authors: gherardini j. Int J Mol Sci. 2025 Aug 13;26(16):7811. doi: 10.3390/ijms26167811. Int J Mol Sci. 2025. PMID: 40869132 Free PMC article.

5

Comment on "Human scalp hair follicles can 'taste': chemosensory signalling via the bitter taste receptor TAS2R4 inhibits hair growth ex vivo": reply from authors.

Gherardini J, Cheret J, Paus R. Gherardini J, et al. Br J Dermatol. 2025 Oct 17;193(5):1030-1031. doi: 10.1093/bjd/ljaf244. Br J Dermatol. 2025. PMID: 40576445 No abstract available.

6

Pilot evidence that topically applied triiodothyronine can stimulate hair growth in human scalp skin.

Gherardini J, Akhundlu A, Gompels M, Verbinnen A, Velasco S, Knie U, Kassir R, Chéret J, Paus R. Gherardini J, et al. Clin Exp Dermatol. 2025 Aug 22;50(9):1862-1864. doi: 10.1093/ced/llaf190. Clin Exp Dermatol. 2025. PMID: 40275449 No abstract available.

7

Human scalp hair follicles can 'taste': chemosensory signalling via the bitter taste receptor TAS2R4 inhibits hair growth ex vivo.

Gherardini J, Rouillé T, Stone RC, Fehrholz M, Funk W, Rodríguez-Feliz J, Bauman AJ, Bíró T, Chéret J, Paus R. Gherardini J, et al. Br J Dermatol. 2025 May 19;192(6):1083-1095. doi: 10.1093/bjd/ljaf060. Br J Dermatol. 2025. PMID: 40097020

8

Interleukin-15 is a hair follicle immune privilege guardian.

Suzuki T, Chéret J, Scala FD, Rajabi-Estarabadi A, Akhundlu A, Demetrius DL, Gherardini J, Keren A, Harries M, Rodriguez-Feliz J, Epstein G, Lee W, Purba T, Gilhar A, Paus R. Suzuki T, et al. Among authors: gherardini j. J Autoimmun. 2024 May;145:103217. doi: 10.1016/j.jaut.2024.103217. Epub 2024 Apr 5. J Autoimmun. 2024. PMID: 38581915

9

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo.

Samra T, Gomez-Gomez T, Linowiecka K, Akhundlu A, Lopez de Mendoza G, Gompels M, Lee WW, Gherardini J, Chéret J, Paus R. Samra T, et al. Among authors: gherardini j. Int J Mol Sci. 2023 Nov 4;24(21):15963. doi: 10.3390/ijms242115963. Int J Mol Sci. 2023. PMID: 37958946 Free PMC article.

10

Mechanical epilation exerts complex biological effects on human hair follicles and perifollicular skin: An ex vivo study approach.

Bertolini M, Gherardini J, Chéret J, Alam M, Sulk M, Botchkareva NV, Biro T, Funk W, Grieshaber F, Paus R. Bertolini M, et al. Among authors: gherardini j. Int J Cosmet Sci. 2024 Apr;46(2):175-198. doi: 10.1111/ics.12923. Epub 2023 Dec 20. Int J Cosmet Sci. 2024. PMID: 37923568

11

Melatonin Protects K15⁺ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes against Paclitaxel-Induced Damage Ex Vivo.

Samra T, Chéret J, Gherardini J, Verling S, Kassir R, Paus R. Samra T, et al. J Invest Dermatol. 2024 Mar;144(3):697-701.e6. doi: 10.1016/j.jid.2023.09.004. Epub 2023 Sep 28. J Invest Dermatol. 2024. PMID: 37775037 Free article. No abstract available.

12

IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles.

Suzuki T, Scala F, Demetrius DL, Gherardini J, Rodriguez-Feliz J, Kuka-Epstein G, Chéret J, Paus R. Suzuki T, et al. J Invest Dermatol. 2024 Jan;144(1):165-170.e5. doi: 10.1016/j.jid.2023.06.206. Epub 2023 Aug 4. J Invest Dermatol. 2024. PMID: 37543243 Free article. No abstract available.

13

mTORC1 activity negatively regulates human hair follicle growth and pigmentation.

Suzuki T, Chéret J, Scala FD, Akhundlu A, Gherardini J, Demetrius DL, O'Sullivan JDB, Kuka Epstein G, Bauman AJ, Demetriades C, Paus R. Suzuki T, et al. EMBO Rep. 2023 Jul 5;24(7):e56574. doi: 10.15252/embr.202256574. Epub 2023 May 22. EMBO Rep. 2023. PMID: 37212043 Free PMC article.

14

Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity.

Cheret J, Samra T, Verling SD, Gherardini J, Rodriguez-Feliz J, Bauman AJ, Sanchez CA, Wikramanayake TC, Xu XX, Paus R. Cheret J, et al. J Invest Dermatol. 2023 Sep;143(9):1809-1813.e2. doi: 10.1016/j.jid.2023.02.033. Epub 2023 Mar 28. J Invest Dermatol. 2023. PMID: 36990174 Free article. No abstract available.

15

Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex Vivo.

Horesh EJ, Gherardini J, Alam M, Rodriguez-Feliz J, Bauman AJ, Chéret J, Paus R. Horesh EJ, et al. J Invest Dermatol. 2023 May;143(5):868-871.e7. doi: 10.1016/j.jid.2022.09.660. Epub 2022 Dec 7. J Invest Dermatol. 2023. PMID: 36496194 Free article. No abstract available.

16

Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy?

Gherardini J, Rivas KE, Chéret J, Strbo N, Paus R. Gherardini J, et al. J Eur Acad Dermatol Venereol. 2022 Dec;36(12):e1013-e1015. doi: 10.1111/jdv.18423. Epub 2022 Jul 26. J Eur Acad Dermatol Venereol. 2022. PMID: 35841295 No abstract available.

17

Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation.

Wikramanayake TC, Nicu C, Gherardini J, Mello ACGCV, Chéret J, Paus R. Wikramanayake TC, et al. J Invest Dermatol. 2022 Sep;142(9):2524-2527.e7. doi: 10.1016/j.jid.2021.12.037. Epub 2022 Feb 13. J Invest Dermatol. 2022. PMID: 35172193 Free article. No abstract available.

18

Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle.

Uchida Y, Gherardini J, Pappelbaum K, Chéret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R. Uchida Y, et al. J Autoimmun. 2021 Nov;124:102711. doi: 10.1016/j.jaut.2021.102711. Epub 2021 Aug 31. J Autoimmun. 2021. PMID: 34479087

19

Sensory Reinnervation of Human Skin by Human Neural Stem Cell‒Derived Peripheral Neurons Ex Vivo.

Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R. Chéret J, et al. J Invest Dermatol. 2022 Jan;142(1):257-261.e5. doi: 10.1016/j.jid.2021.05.032. Epub 2021 Jul 20. J Invest Dermatol. 2022. PMID: 34293348 Free article. No abstract available.

20

A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

Jozic I, Chéret J, Abujamra BA, Miteva M, Gherardini J, Paus R. Jozic I, et al. Biomedicines. 2021 May 19;9(5):572. doi: 10.3390/biomedicines9050572. Biomedicines. 2021. PMID: 34069454 Free PMC article.

21

Pro-inflammatory Vδ1⁺T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles.

Uchida Y, Gherardini J, Schulte-Mecklenbeck A, Alam M, Chéret J, Rossi A, Kanekura T, Gross CC, Arakawa A, Gilhar A, Bertolini M, Paus R. Uchida Y, et al. J Dermatol Sci. 2020 Nov;100(2):129-138. doi: 10.1016/j.jdermsci.2020.09.001. Epub 2020 Sep 18. J Dermatol Sci. 2020. PMID: 33039243

22

Non-neuronal kappa-opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo.

Chéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus R. Chéret J, et al. J Dermatol. 2020 Aug;47(8):917-921. doi: 10.1111/1346-8138.15407. Epub 2020 Jun 14. J Dermatol. 2020. PMID: 32537810

23

Human Wound Healing Ex Vivo Model with Focus on Molecular Markers.

Gherardini J, van Lessen M, Piccini I, Edelkamp J, Bertolini M. Gherardini J, et al. Methods Mol Biol. 2020;2154:249-254. doi: 10.1007/978-1-0716-0648-3_21. Methods Mol Biol. 2020. PMID: 32314223

24

Methods to Study Human Hair Follicle Growth Ex Vivo: Human Microdissected Hair Follicle and Human Full Thickness Skin Organ Culture.

Edelkamp J, Gherardini J, Bertolini M. Edelkamp J, et al. Methods Mol Biol. 2020;2154:105-119. doi: 10.1007/978-1-0716-0648-3_9. Methods Mol Biol. 2020. PMID: 32314211

25

Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo.

Gherardini J, Uchida Y, Hardman JA, Chéret J, Mace K, Bertolini M, Paus R. Gherardini J, et al. PLoS One. 2020 Jan 23;15(1):e0227817. doi: 10.1371/journal.pone.0227817. eCollection 2020. PLoS One. 2020. PMID: 31971954 Free PMC article.

26

Fluoxetine promotes human hair follicle pigmentation ex vivo: serotonin reuptake inhibition as a new antigreying strategy?

Chéret J, Gherardini J, Bertolini M, Paus R. Chéret J, et al. Br J Dermatol. 2020 Jun;182(6):1492-1494. doi: 10.1111/bjd.18819. Epub 2020 Jan 30. Br J Dermatol. 2020. PMID: 31872421 No abstract available.

27

Theophylline exerts complex anti-ageing and anti-cytotoxicity effects in human skin ex vivo.

Bertolini M, Ramot Y, Gherardini J, Heinen G, Chéret J, Welss T, Giesen M, Funk W, Paus R. Bertolini M, et al. Int J Cosmet Sci. 2020 Feb;42(1):79-88. doi: 10.1111/ics.12589. Epub 2019 Dec 17. Int J Cosmet Sci. 2020. PMID: 31633195

28

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes.

Alam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus R. Alam M, et al. Br J Dermatol. 2020 Jun;182(6):1404-1414. doi: 10.1111/bjd.18479. Epub 2019 Nov 1. Br J Dermatol. 2020. PMID: 31487385

29

Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine.

Gherardini J, Wegner J, Chéret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Böhm M, Botchkareva NV, Ward C, Paus R, Bertolini M. Gherardini J, et al. Int J Cosmet Sci. 2019 Apr;41(2):164-182. doi: 10.1111/ics.12521. Int J Cosmet Sci. 2019. PMID: 30746733 Free PMC article.

30

The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo.

Oláh A, Gherardini J, Bertolini M, Chéret J, Ponce L, Kloepper J, Bíró T, Soeberdt M, Abels C, Paus R. Oláh A, et al. J Invest Dermatol. 2016 Aug;136(8):1711-1714. doi: 10.1016/j.jid.2016.03.033. Epub 2016 Apr 8. J Invest Dermatol. 2016. PMID: 27066887 Free article. No abstract available.

31

Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse.

Bertolini M, Pretzlaff M, Sulk M, Bähr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Bíró T, Paus R. Bertolini M, et al. Br J Dermatol. 2016 Sep;175(3):531-41. doi: 10.1111/bjd.14645. Epub 2016 Aug 9. Br J Dermatol. 2016. PMID: 27059672

32

The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase.

Vitadello M, Gherardini J, Gorza L. Vitadello M, et al. Antioxid Redox Signal. 2014 Jun 1;20(16):2479-96. doi: 10.1089/ars.2012.4794. Epub 2013 Nov 26. Antioxid Redox Signal. 2014. PMID: 24093939 Free PMC article.

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