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Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice.
Lentz JJ, Pan B, Ponnath A, Tran CM, Nist-Lund C, Galvin A, Goldberg H, Robillard KN, Jodelka FM, Farris HE, Huang J, Chen T, Zhu H, Zhou W, Rigo F, Hastings ML, Géléoc GSG. Lentz JJ, et al. Among authors: hastings ml. Mol Ther. 2020 Dec 2;28(12):2662-2676. doi: 10.1016/j.ymthe.2020.08.002. Epub 2020 Aug 5. Mol Ther. 2020. PMID: 32818431 Free PMC article.
Identification of SRSF10 as a regulator of SMN2 ISS-N1.
Frederiksen SB, Holm LL, Larsen MR, Doktor TK, Andersen HS, Hastings ML, Hua Y, Krainer AR, Andresen BS. Frederiksen SB, et al. Among authors: hastings ml. Hum Mutat. 2021 Mar;42(3):246-260. doi: 10.1002/humu.24149. Epub 2020 Dec 16. Hum Mutat. 2021. PMID: 33300159 Free PMC article.
Corticosteroid sensitization drives opioid addiction.
Carmack SA, Vendruscolo JCM, Adrienne McGinn M, Miranda-Barrientos J, Repunte-Canonigo V, Bosse GD, Mercatelli D, Giorgi FM, Fu Y, Hinrich AJ, Jodelka FM, Ling K, Messing RO, Peterson RT, Rigo F, Edwards S, Sanna PP, Morales M, Hastings ML, Koob GF, Vendruscolo LF. Carmack SA, et al. Among authors: hastings ml. Mol Psychiatry. 2022 May;27(5):2492-2501. doi: 10.1038/s41380-022-01501-1. Epub 2022 Mar 16. Mol Psychiatry. 2022. PMID: 35296810
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation.
Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O. Korecka JA, et al. Among authors: hastings ml. Stem Cell Reports. 2019 Jan 8;12(1):29-41. doi: 10.1016/j.stemcr.2018.11.021. Epub 2018 Dec 27. Stem Cell Reports. 2019. PMID: 30595548 Free PMC article.
Searching for novel biomarkers using a mouse model of CLN3-Batten disease.
Timm D, Cain JT, Geraets RD, White KA, Koh SY, Kielian T, Pearce DA, Hastings ML, Weimer JM. Timm D, et al. Among authors: hastings ml. PLoS One. 2018 Aug 7;13(8):e0201470. doi: 10.1371/journal.pone.0201470. eCollection 2018. PLoS One. 2018. PMID: 30086172 Free PMC article.
Splice-switching antisense oligonucleotides as therapeutic drugs.
Havens MA, Hastings ML. Havens MA, et al. Among authors: hastings ml. Nucleic Acids Res. 2016 Aug 19;44(14):6549-63. doi: 10.1093/nar/gkw533. Epub 2016 Jun 10. Nucleic Acids Res. 2016. PMID: 27288447 Free PMC article. Review.
A big score for RNA.
Hastings ML. Hastings ML. RNA. 2015 Apr;21(4):634-5. doi: 10.1261/rna.050757.115. RNA. 2015. PMID: 25780170 Free PMC article. No abstract available.
Drosha promotes splicing of a pre-microRNA-like alternative exon.
Havens MA, Reich AA, Hastings ML. Havens MA, et al. Among authors: hastings ml. PLoS Genet. 2014 May 1;10(5):e1004312. doi: 10.1371/journal.pgen.1004312. eCollection 2014 May. PLoS Genet. 2014. PMID: 24786770 Free PMC article.
SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant.
Dauber A, Golzio C, Guenot C, Jodelka FM, Kibaek M, Kjaergaard S, Leheup B, Martinet D, Nowaczyk MJ, Rosenfeld JA, Zeesman S, Zunich J, Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S, Katsanis N. Dauber A, et al. Among authors: hastings ml. Am J Hum Genet. 2013 Nov 7;93(5):798-811. doi: 10.1016/j.ajhg.2013.09.010. Epub 2013 Oct 17. Am J Hum Genet. 2013. PMID: 24140112 Free PMC article.
Targeting RNA splicing for disease therapy.
Havens MA, Duelli DM, Hastings ML. Havens MA, et al. Among authors: hastings ml. Wiley Interdiscip Rev RNA. 2013 May-Jun;4(3):247-66. doi: 10.1002/wrna.1158. Epub 2013 Mar 19. Wiley Interdiscip Rev RNA. 2013. PMID: 23512601 Free PMC article. Review.
Authors' reply.
Duelli DM, Palma J, Beaman K, Hastings ML, Kwak-Kim J, Linnstaedt S, Park JC, Kim DJ. Duelli DM, et al. Among authors: hastings ml. J Mol Diagn. 2013 Jan;15(1):138-9. J Mol Diagn. 2013. PMID: 23390637 No abstract available.
MicroRNAs are exported from malignant cells in customized particles.
Palma J, Yaddanapudi SC, Pigati L, Havens MA, Jeong S, Weiner GA, Weimer KM, Stern B, Hastings ML, Duelli DM. Palma J, et al. Among authors: hastings ml. Nucleic Acids Res. 2012 Oct;40(18):9125-38. doi: 10.1093/nar/gks656. Epub 2012 Jul 5. Nucleic Acids Res. 2012. PMID: 22772984 Free PMC article.
Plasma components affect accuracy of circulating cancer-related microRNA quantitation.
Kim DJ, Linnstaedt S, Palma J, Park JC, Ntrivalas E, Kwak-Kim JY, Gilman-Sachs A, Beaman K, Hastings ML, Martin JN, Duelli DM. Kim DJ, et al. Among authors: hastings ml. J Mol Diagn. 2012 Jan;14(1):71-80. doi: 10.1016/j.jmoldx.2011.09.002. Epub 2011 Nov 30. J Mol Diagn. 2012. PMID: 22154918 Free PMC article.
Comprehensive splice-site analysis using comparative genomics.
Sheth N, Roca X, Hastings ML, Roeder T, Krainer AR, Sachidanandam R. Sheth N, et al. Among authors: hastings ml. Nucleic Acids Res. 2006;34(14):3955-67. doi: 10.1093/nar/gkl556. Epub 2006 Aug 12. Nucleic Acids Res. 2006. PMID: 16914448 Free PMC article.
Pre-mRNA splicing in the new millennium.
Hastings ML, Krainer AR. Hastings ML, et al. Curr Opin Cell Biol. 2001 Jun;13(3):302-9. doi: 10.1016/s0955-0674(00)00212-x. Curr Opin Cell Biol. 2001. PMID: 11343900 Review.