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Page 1
Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis.
Sachdev V, van Loon NM, Kingma J, Ottenhoff R, Tan JME, van den Berg M, Duijst S, Jongejan A, Levels JHM, Rensen PCN, Kooijman S, de Boer JF, Kuipers F, Kuentzel KB, Kratky D, Kwon Y, Zeigerer A, Hendrix S, Zelcer N. Sachdev V, et al. Among authors: hendrix s. Mol Metab. 2026 Jun;108:102379. doi: 10.1016/j.molmet.2026.102379. Epub 2026 May 2. Mol Metab. 2026. PMID: 42082151 Free PMC article.
Target product profiles for treatments to delay or prevent symptomatic Alzheimer's disease.
Cummings JL, Agadjanyan MG, Barry M, Corey L, Doody R, Hendrix S, Mattke S, Mattsson-Carlgren N, McDade E, Menetski JP, Mohs RC, Partrick KA, Petrovsky N, Selkoe DJ, Silva D, Sperling RA, Tiede B, Vradenburg G. Cummings JL, et al. Among authors: hendrix s. Nat Med. 2026 Apr;32(4):1223-1232. doi: 10.1038/s41591-026-04305-w. Epub 2026 Apr 3. Nat Med. 2026. PMID: 41933174 Review.
Incorporating Patient Perspectives into a Composite Score for Measuring Disease Progression in Spinocerebellar Ataxia (SCA).
Potashman MH, Rogula BM, Powell LC, Korol EE, Dickson SP, Hendrix S, Heinrich M, Rudell K, Abetz-Webb L, Beiner MW, Coric V, Rosenthal LS, Perlman SL, Schmahmann JD, L'Italien G. Potashman MH, et al. Among authors: hendrix s. Neurol Ther. 2026 Apr;15(2):807-816. doi: 10.1007/s40120-026-00891-6. Epub 2026 Feb 18. Neurol Ther. 2026. PMID: 41706362 Free PMC article.
Phase 3 randomized clinical trials of simufilam in mild-to-moderate Alzheimer's disease.
Kupiec JW, Porsteinsson AP, Turner RS, Hendrix S, Mallinckrodt C, Khan A, Cohen I, Liss J, Clarnette R, Park KH, Hernandez AM, Burns LH. Kupiec JW, et al. Among authors: hendrix s. J Prev Alzheimers Dis. 2026 Mar;13(3):100469. doi: 10.1016/j.tjpad.2025.100469. Epub 2026 Jan 6. J Prev Alzheimers Dis. 2026. PMID: 41500915 Free PMC article. Clinical Trial.
Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer's Disease: Synthesis of Evidence from Observational and Interventional Trials.
Abushakra S, Doraiswamy PM, Hey JA, Tosun D, Barkhof F, Barakos J, Petrella J, Kesslak JP, Power A, Sabbagh M, Porsteinsson A, Cohen S, Gauthier S, Ritchie C, Watson D, McSweeney E, Boada M, Liang E, Bracoud L, McLaine R, Flint S, Schaefer JF, Yu J, Bray M, Hendrix S, Dickson S, Durrant A, Albayrak A, Tolar M. Abushakra S, et al. Among authors: hendrix s. CNS Drugs. 2026 Feb;40(2):199-214. doi: 10.1007/s40263-025-01251-y. Epub 2025 Dec 1. CNS Drugs. 2026. PMID: 41324786 Free PMC article. Review.
Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition.
Niccolai R, Göbel C, Ndoj K, Kreft M, Kuiken HJ, Lieftink C, Morris B, Yska SD, Hendrix S, van den Broek B, Pappalardo V, Kersten MJ, Beijersbergen RL, Zelcer N, van Leeuwen F, Jacobs H. Niccolai R, et al. Among authors: hendrix s. Neoplasia. 2025 Dec;70:101243. doi: 10.1016/j.neo.2025.101243. Epub 2025 Oct 27. Neoplasia. 2025. PMID: 41151153 Free PMC article.
Development of composite scales for assessing disease progression and treatment effects among patients with Parkinson's disease in a clinical trial setting.
L'Italien G, Rogula B, Powell LC, Potashman M, Dickson SP, Kozauer N, O'Keefe P, Korol EE, Crabtree M, Nagase F, Coric V, Dubow J, Rosenthal LS, Hendrix S; CPP Integrated Parkinson's Database. L'Italien G, et al. Among authors: hendrix s. Parkinsonism Relat Disord. 2025 Dec;141:108077. doi: 10.1016/j.parkreldis.2025.108077. Epub 2025 Oct 10. Parkinsonism Relat Disord. 2025. PMID: 41106090 Free article.
Efficacy of AD04, an aluminum-based vaccine adjuvant, in patients with early Alzheimer's disease: Post hoc analysis of AFF006 (NCT01117818), a proof-of-concept, phase 2 randomized controlled trial.
Haaland B, Dickson SP, Santana AF, Tanzi RE, Dubois B, Peters O, Grimmer T, Christensen J, Mallinckrodt C, Schneeberger A, Hendrix SB. Haaland B, et al. J Alzheimers Dis. 2025 Nov;108(1):234-242. doi: 10.1177/13872877251375985. Epub 2025 Sep 15. J Alzheimers Dis. 2025. PMID: 40953123 Clinical Trial.
Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease.
Nuytten M, Voets M, Debroux E, Princen K, Pringels L, Fivaz M, Byl E, Ramael S, De Witte K, Boada M, Morató X, Tartari JP, Lafuente A, Macias EF, Matias-Guiu JA, Vijverberg E, Teunissen CE, Anderer P, Staggs V, Hayman V, Corbett A, Ballard C, Harrison JE, Windisch M, Westman AB, Zetterberg H, Dickson S, Mallinckrodt C, Hendrix S, Cummings J, Griffioen G. Nuytten M, et al. Among authors: hendrix s. Alzheimers Dement. 2025 Sep;21(9):e70537. doi: 10.1002/alz.70537. Alzheimers Dement. 2025. PMID: 40937833 Free PMC article. Clinical Trial.
Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses.
Dubey N, Woodson R, Hendrix SV, Rosen AL, Kinsella RL, McKee SR, Starick M, Rivera-Espinal N, Naik SK, Smirnov A, Kreamalmeyer D, Kau AL, Stallings CL. Dubey N, et al. bioRxiv [Preprint]. 2025 Aug 5:2023.03.16.533006. doi: 10.1101/2023.03.16.533006. bioRxiv. 2025. Update in: Autophagy. 2026 May 19:1-18. doi: 10.1080/15548627.2026.2668861. PMID: 40799574 Free PMC article. Updated. Preprint.
Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson's Disease.
L'Italien G, Rogula B, Powell L, Potashman M, Dickson SP, Kozauer N, O'Keefe P, Korol E, Crabtree M, Nagase F, Coric V, Dubow J, Rosenthal LS, Hendrix S. L'Italien G, et al. Among authors: hendrix s. Neurol Ther. 2025 Aug;14(4):1609-1625. doi: 10.1007/s40120-025-00771-5. Epub 2025 Jun 16. Neurol Ther. 2025. PMID: 40518466 Free PMC article.
Time saved in activities of daily living and whole-brain volume: Post hoc analysis of a randomized feasibility trial of gamma oscillation treatment in participants with mild or moderate Alzheimer's disease.
Kern R, Haaland B, Nicodemus-Johnson J, Dickson S, Morgan M, Christensen JR, Sabbagh MN, Lee L, Hajós M, Riddle J, Seshagiri CV, Howell C, Mallinckrodt C, Hendrix S. Kern R, et al. Among authors: hendrix s. Alzheimers Dement (N Y). 2025 Jun 11;11(2):e70118. doi: 10.1002/trc2.70118. eCollection 2025 Apr-Jun. Alzheimers Dement (N Y). 2025. PMID: 40501511 Free PMC article.
Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease.
Garbarino VR, Palavicini JP, Melendez J, Barthelemy NR, He Y, Kautz TF, Lopez-Cruzan M, Mathews JJ, Xu P, Zhang B, Saliba A, Ragi N, Sharma K, Mason D, Johnson S, Hendrix S, Craft S, Petersen RC, Espindola-Netto JM, Xue A, Tchkonia T, Kirkland JL, Salardini A, Musi N, Bateman RJ, Gonzales MM, Orr ME. Garbarino VR, et al. Among authors: hendrix s. Neurotherapeutics. 2025 Jul;22(4):e00591. doi: 10.1016/j.neurot.2025.e00591. Epub 2025 Apr 23. Neurotherapeutics. 2025. PMID: 40274471 Free PMC article. Clinical Trial.
Donanemab: Appropriate use recommendations.
Rabinovici GD, Selkoe DJ, Schindler SE, Aisen P, Apostolova LG, Atri A, Greenberg SM, Hendrix SB, Petersen RC, Weiner M, Salloway S, Cummings J. Rabinovici GD, et al. Among authors: hendrix sb. J Prev Alzheimers Dis. 2025 May;12(5):100150. doi: 10.1016/j.tjpad.2025.100150. Epub 2025 Mar 27. J Prev Alzheimers Dis. 2025. PMID: 40155270 Free PMC article.
Key considerations for combination therapy in Alzheimer's clinical trials: Perspectives from an expert advisory board convened by the Alzheimer's drug discovery foundation.
Cummings J, Gold M, Mintun M, Irizarry M, von Eschenbach A, Hendrix S, Berry D, Sampaio C, Sink K, Landen J, Kivipelto M, Grundman M, Arnold SE, Green A, Partrick K, Nisenbaum L, Burstein A, Fillit H. Cummings J, et al. Among authors: hendrix s. J Prev Alzheimers Dis. 2025 Jan;12(1):100001. doi: 10.1016/j.tjpad.2024.100001. Epub 2025 Jan 1. J Prev Alzheimers Dis. 2025. PMID: 39800453 Free PMC article.
Results of the ACTION-Galactosemia Kids Study to Evaluate the Effects of Govorestat in Pediatric Patients with Classic Galactosemia.
Bailey E, Phan H, Ahmad A, Thomas J, Ames EG, Pritchard AB, Quinonez SC, Wang S, Dayley C, Salt A, Pick C, Durrant A, Johnson S, Nicodemus-Johnson J, Dickson SP, Perfetti R, Hendrix SB, Shendelman S. Bailey E, et al. Among authors: hendrix sb. J Clin Pharmacol. 2025 May;65(5):575-587. doi: 10.1002/jcph.6170. Epub 2024 Nov 21. J Clin Pharmacol. 2025. PMID: 39569553 Free PMC article. Clinical Trial.
Glutamine sensing licenses cholesterol synthesis.
Garcia BM, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L. Garcia BM, et al. Among authors: hendrix s. EMBO J. 2024 Dec;43(23):5837-5856. doi: 10.1038/s44318-024-00269-0. Epub 2024 Oct 21. EMBO J. 2024. PMID: 39433901 Free PMC article.
Clinical Meaningfulness in Alzheimer's Disease Clinical Trials. A Report from the EU-US CTAD Task Force.
Angioni D, Cummings J, Lansdall CJ, Middleton L, Sampaio C, Gauthier S, Cohen S, Petersen RC, Rentz DM, Wessels AM, Hendrix SB, Jessen F, Carrillo MC, Doody RS, Irizarry M, Andrews JS, Vellas B, Aisen P. Angioni D, et al. Among authors: hendrix sb. J Prev Alzheimers Dis. 2024;11(5):1219-1227. doi: 10.14283/jpad.2024.112. J Prev Alzheimers Dis. 2024. PMID: 39350367 Free PMC article.
Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer's disease.
Arnold SE, Hendrix S, Nicodemus-Johnson J, Knowlton N, Williams VJ, Burns JM, Crane M, McManus AJ, Vaishnavi SN, Arvanitakis Z, Neugroschl J, Bell K, Trombetta BA, Carlyle BC, Kivisäkk P, Dodge HH, Tanzi RE, Yeramian PD, Leslie K. Arnold SE, et al. Among authors: hendrix s. Alzheimers Dement (N Y). 2024 Aug 9;10(3):e12487. doi: 10.1002/trc2.12487. eCollection 2024 Jul-Sep. Alzheimers Dement (N Y). 2024. PMID: 39131742 Free PMC article.
Are immunosenescent T cells really senescent?
Slaets H, Veeningen N, de Keizer PLJ, Hellings N, Hendrix S. Slaets H, et al. Among authors: hendrix s. Aging Cell. 2024 Oct;23(10):e14300. doi: 10.1111/acel.14300. Epub 2024 Aug 7. Aging Cell. 2024. PMID: 39113243 Free PMC article. Review.
Invasion and spread of the neotropical leafhopper Curtara insularis (Hemiptera: Cicadellidae) in Africa and North America and the role of high-altitude windborne migration in invasive insects.
Nartey R, Chamorro L, Buffington M, Afrane YA, Mohammed AR, Owusu-Asenso CM, Akosah-Brempong G, Pambit Zong CM, Hendrix SV, Dao A, Yaro AS, Diallo M, Sanogo ZL, Djibril S, Halbert SE, Bamou R, Nance CE, Bartlett CR, Reynolds DR, Chapman JW, Obiri-Danso K, Lehmann T. Nartey R, et al. Among authors: hendrix sv. bioRxiv [Preprint]. 2024 May 30:2024.05.24.595796. doi: 10.1101/2024.05.24.595796. bioRxiv. 2024. PMID: 38854158 Free PMC article. Preprint.
Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition.
Schepers M, Hendrix S, Mussen F, van Breedam E, Ponsaerts P, Lemmens S, Hellings N, Ricciarelli R, Fedele E, Bruno O, Brullo C, Prickaerts J, Van Broeckhoven J, Vanmierlo T. Schepers M, et al. Among authors: hendrix s. Neurotherapeutics. 2024 Jul;21(4):e00372. doi: 10.1016/j.neurot.2024.e00372. Epub 2024 May 16. Neurotherapeutics. 2024. PMID: 38760316 Free PMC article.
"Time Saved" Calculations to Improve Decision-Making in Progressive Disease Studies.
Dickson SP, Haaland B, Mallinckrodt CH, Dubois B, O'Keefe P, Morgan M, Peters O, Fernández Santana Iii A, Harrison J, Schneeberger A, Hendrix S. Dickson SP, et al. Among authors: hendrix s. J Prev Alzheimers Dis. 2024;11(3):529-536. doi: 10.14283/jpad.2024.64. J Prev Alzheimers Dis. 2024. PMID: 38706269 Free PMC article. Clinical Trial.
Autophagy promotes efficient T cell responses to restrict high-dose Mycobacterium tuberculosis infection in mice.
Feng S, McNehlan ME, Kinsella RL, Sur Chowdhury C, Chavez SM, Naik SK, McKee SR, Van Winkle JA, Dubey N, Samuels A, Swain A, Cui X, Hendrix SV, Woodson R, Kreamalmeyer D, Smirnov A, Artyomov MN, Virgin HW, Wang YT, Stallings CL. Feng S, et al. Among authors: hendrix sv. Nat Microbiol. 2024 Mar;9(3):684-697. doi: 10.1038/s41564-024-01608-x. Epub 2024 Feb 27. Nat Microbiol. 2024. PMID: 38413834 Free PMC article.
Challenges in developing Geroscience trials.
Rolland Y, Sierra F, Ferrucci L, Barzilai N, De Cabo R, Mannick J, Oliva A, Evans W, Angioni D, De Souto Barreto P, Raffin J, Vellas B, Kirkland JL; G.C.T-TF group. Rolland Y, et al. Nat Commun. 2023 Aug 19;14(1):5038. doi: 10.1038/s41467-023-39786-7. Nat Commun. 2023. PMID: 37598227 Free PMC article. Review.
A new SPRING in lipid metabolism.
Hendrix S, Zelcer N. Hendrix S, et al. Curr Opin Lipidol. 2023 Oct 1;34(5):201-207. doi: 10.1097/MOL.0000000000000894. Epub 2023 Aug 3. Curr Opin Lipidol. 2023. PMID: 37548386 Review.
Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer's Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial.
Hendrix SB, Soininen H, Solomon A, Visser PJ, van Hees AMJ, Counotte DS, Nicodemus-Johnson J, Dickson SP, Blennow K, Kivipelto M, Hartmann T. Hendrix SB, et al. J Prev Alzheimers Dis. 2023;10(3):464-470. doi: 10.14283/jpad.2023.29. J Prev Alzheimers Dis. 2023. PMID: 37357286 Clinical Trial.
Lecanemab: Appropriate Use Recommendations.
Cummings J, Apostolova L, Rabinovici GD, Atri A, Aisen P, Greenberg S, Hendrix S, Selkoe D, Weiner M, Petersen RC, Salloway S. Cummings J, et al. Among authors: hendrix s. J Prev Alzheimers Dis. 2023;10(3):362-377. doi: 10.14283/jpad.2023.30. J Prev Alzheimers Dis. 2023. PMID: 37357276 Free PMC article.
Why a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease.
Jutten RJ, Papp KV, Hendrix S, Ellison N, Langbaum JB, Donohue MC, Hassenstab J, Maruff P, Rentz DM, Harrison J, Cummings J, Scheltens P, Sikkes SAM. Jutten RJ, et al. Among authors: hendrix s. Alzheimers Dement. 2023 Feb;19(2):708-720. doi: 10.1002/alz.12773. Epub 2022 Sep 10. Alzheimers Dement. 2023. PMID: 36086926 Free PMC article.
Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial.
Paganoni S, Hendrix S, Dickson SP, Knowlton N, Berry JD, Elliott MA, Maiser S, Karam C, Caress JB, Owegi MA, Quick A, Wymer J, Goutman SA, Heitzman D, Heiman-Patterson TD, Jackson C, Quinn C, Rothstein JD, Kasarskis EJ, Katz J, Jenkins L, Ladha SS, Miller TM, Scelsa SN, Vu TH, Fournier C, Johnson KM, Swenson A, Goyal N, Pattee GL, Babu S, Chase M, Dagostino D, Hall M, Kittle G, Eydinov M, Ostrow J, Pothier L, Randall R, Shefner JM, Sherman AV, Tustison E, Vigneswaran P, Yu H, Cohen J, Klee J, Tanzi R, Gilbert W, Yeramian P, Cudkowicz M. Paganoni S, et al. Among authors: hendrix s. J Neurol Neurosurg Psychiatry. 2022 May 16;93(8):871-5. doi: 10.1136/jnnp-2022-329024. Online ahead of print. J Neurol Neurosurg Psychiatry. 2022. PMID: 35577511 Free PMC article.
Aducanumab: Appropriate Use Recommendations Update.
Cummings J, Rabinovici GD, Atri A, Aisen P, Apostolova LG, Hendrix S, Sabbagh M, Selkoe D, Weiner M, Salloway S. Cummings J, et al. Among authors: hendrix s. J Prev Alzheimers Dis. 2022;9(2):221-230. doi: 10.14283/jpad.2022.34. J Prev Alzheimers Dis. 2022. PMID: 35542993 Free PMC article.
Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy (HOPE-2): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
McDonald CM, Marbán E, Hendrix S, Hogan N, Ruckdeschel Smith R, Eagle M, Finkel RS, Tian C, Janas J, Harmelink MM, Varadhachary AS, Taylor MD, Hor KN, Mayer OH, Henricson EK, Furlong P, Ascheim DD, Rogy S, Williams P, Marbán L; HOPE-2 Study Group. McDonald CM, et al. Among authors: hendrix s. Lancet. 2022 Mar 12;399(10329):1049-1058. doi: 10.1016/S0140-6736(22)00012-5. Lancet. 2022. PMID: 35279258 Free article. Clinical Trial.
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