Higashi Y - Search Results

1

A body shape index is associated with endothelial dysfunction in both men and women.

Kajikawa M, Maruhashi T, Kishimoto S, Yamaji T, Harada T, Hashimoto Y, Han Y, Mizobuchi A, Aoki G, Yoshimura K, Chayama K, Goto C, Yusoff FM, Nakashima A, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Sci Rep. 2021 Sep 9;11(1):17873. doi: 10.1038/s41598-021-97325-0. Sci Rep. 2021. PMID: 34504193 Free PMC article.

2

Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women.

Higashi Y, Sanada M, Sasaki S, Nakagawa K, Goto C, Matsuura H, Ohama K, Chayama K, Oshima T. Higashi Y, et al. Hypertension. 2001 Feb;37(2 Pt 2):651-7. doi: 10.1161/01.hyp.37.2.651. Hypertension. 2001. PMID: 11230351 Clinical Trial.

3

Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho-vagal nervous activity and progress in retinopathy.

Nakano Y, Oshima T, Ozono R, Higashi Y, Sasaki S, Matsumoto T, Matsuura H, Chayama K, Kambe M. Nakano Y, et al. Among authors: higashi y. Auton Neurosci. 2001 May 14;88(3):181-6. doi: 10.1016/S1566-0702(01)00238-7. Auton Neurosci. 2001. PMID: 11474560

4

Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension.

Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Chayama K, Oshima T. Higashi Y, et al. Am J Hypertens. 2001 Oct;14(10):1038-45. doi: 10.1016/s0895-7061(01)02191-4. Am J Hypertens. 2001. PMID: 11710783

5

Sodium chloride loading does not alter endothelium-dependent vasodilation of forearm vasculature in either salt-sensitive or salt-resistant patients with essential hypertension.

Higashi Y, Sasaki S, Nakagawa K, Kimura M, Noma K, Sasaki S, Hara K, Matsuura H, Chayama K, Oshima T. Higashi Y, et al. Hypertens Res. 2001 Nov;24(6):711-6. doi: 10.1291/hypres.24.711. Hypertens Res. 2001. PMID: 11768732 Free article.

6

Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity.

Nakano Y, Oshima T, Sasaki S, Higashi Y, Ozono R, Takenaka S, Miura F, Hirao H, Matsuura H, Chayama K, Kambe M. Nakano Y, et al. Among authors: higashi y. J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S69-74. doi: 10.1097/00005344-200110001-00015. J Cardiovasc Pharmacol. 2001. PMID: 11811363

7

Renal endothelial dysfunction and hypertension.

Higashi Y, Chayama K. Higashi Y, et al. J Diabetes Complications. 2002 Jan-Feb;16(1):103-7. doi: 10.1016/s1056-8727(01)00202-1. J Diabetes Complications. 2002. PMID: 11872376 Review.

8

Excess norepinephrine impairs both endothelium-dependent and -independent vasodilation in patients with pheochromocytoma.

Higashi Y, Sasaki S, Nakagawa K, Kimura M, Sasaki S, Noma K, Matsuura H, Hara K, Goto C, Oshima T, Chayama K. Higashi Y, et al. Hypertension. 2002 Feb;39(2 Pt 2):513-8. doi: 10.1161/hy02t2.102820. Hypertension. 2002. PMID: 11882600

9

Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition.

Higashi Y, Sasaki S, Nakagawa K, Kimura M, Sasaki S, Noma K, Hara K, Matsuura H, Goto C, Oshima T, Chayama K. Higashi Y, et al. J Cardiovasc Pharmacol. 2002 May;39(5):668-76. doi: 10.1097/00005344-200205000-00007. J Cardiovasc Pharmacol. 2002. PMID: 11973410 Clinical Trial.

10

A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension.

Sasaki S, Higashi Y, Nakagawa K, Kimura M, Noma K, Sasaki S, Hara K, Matsuura H, Goto C, Oshima T, Chayama K. Sasaki S, et al. Among authors: higashi y. Am J Hypertens. 2002 Apr;15(4 Pt 1):302-9. doi: 10.1016/s0895-7061(01)02322-6. Am J Hypertens. 2002. PMID: 11991214

11

Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals.

Higashi Y, Sasaki S, Nakagawa K, Fukuda Y, Matsuura H, Oshima T, Chayama K. Higashi Y, et al. Am J Hypertens. 2002 Apr;15(4 Pt 1):326-32. doi: 10.1016/s0895-7061(01)02317-2. Am J Hypertens. 2002. PMID: 11991218

12

Leptin causes vasodilation in humans.

Nakagawa K, Higashi Y, Sasaki S, Oshima T, Matsuura H, Chayama K. Nakagawa K, et al. Among authors: higashi y. Hypertens Res. 2002 Mar;25(2):161-5. doi: 10.1291/hypres.25.161. Hypertens Res. 2002. PMID: 12047029 Free article.

13

Endothelial function and oxidative stress in renovascular hypertension.

Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Oshima T, Chayama K. Higashi Y, et al. N Engl J Med. 2002 Jun 20;346(25):1954-62. doi: 10.1056/NEJMoa013591. N Engl J Med. 2002. PMID: 12075056 Free article.

14

Effect of alcohol consumption on endothelial function in men with coronary artery disease.

Teragawa H, Fukuda Y, Matsuda K, Higashi Y, Yamagata T, Matsuura H, Chayama K. Teragawa H, et al. Among authors: higashi y. Atherosclerosis. 2002 Nov;165(1):145-52. doi: 10.1016/s0021-9150(02)00193-4. Atherosclerosis. 2002. PMID: 12208480

15

Combination therapy of low-dose medroxyprogesterone acetate and oral estrogen does not affect endothelial function in the forearms of postmenopausal women.

Sanada M, Higashi Y, Nakagawa K, Tsuda M, Kodama I, Nagai N, Chayama K, Ohama K. Sanada M, et al. Among authors: higashi y. Menopause. 2002 Sep-Oct;9(5):360-6. doi: 10.1097/00042192-200209000-00009. Menopause. 2002. PMID: 12218725 Clinical Trial.

16

Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women.

Sanada M, Higashi Y, Nakagawa K, Tsuda M, Kodama I, Kimura M, Chayama K, Ohama K. Sanada M, et al. Among authors: higashi y. J Clin Endocrinol Metab. 2002 Oct;87(10):4634-41. doi: 10.1210/jc.2001-011223. J Clin Endocrinol Metab. 2002. PMID: 12364448

17

Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers.

Higashi Y, Nakagawa K, Kimura M, Noma K, Hara K, Sasaki S, Goto C, Oshima T, Chayama K, Yoshizumi M. Higashi Y, et al. J Am Coll Cardiol. 2002 Dec 4;40(11):2039-43. doi: 10.1016/s0735-1097(02)02535-4. J Am Coll Cardiol. 2002. PMID: 12475467 Free article.

18

Leptin causes nitric-oxide independent coronary artery vasodilation in humans.

Matsuda K, Teragawa H, Fukuda Y, Nakagawa K, Higashi Y, Chayama K. Matsuda K, et al. Among authors: higashi y. Hypertens Res. 2003 Feb;26(2):147-52. doi: 10.1291/hypres.26.147. Hypertens Res. 2003. PMID: 12627874 Free article. Clinical Trial.

19

A comparison of low-dose and standard-dose oral estrogen on forearm endothelial function in early postmenopausal women.

Sanada M, Higashi Y, Nakagawa K, Tsuda M, Kodama I, Kimura M, Chayama K, Ohama K. Sanada M, et al. Among authors: higashi y. J Clin Endocrinol Metab. 2003 Mar;88(3):1303-9. doi: 10.1210/jc.2002-021147. J Clin Endocrinol Metab. 2003. PMID: 12629123

20

Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans.

Noma K, Higashi Y, Jitsuiki D, Hara K, Kimura M, Nakagawa K, Goto C, Oshima T, Yoshizumi M, Chayama K. Noma K, et al. Among authors: higashi y. Hypertension. 2003 May;41(5):1102-5. doi: 10.1161/01.HYP.0000067062.92836.9E. Epub 2003 Apr 7. Hypertension. 2003. PMID: 12682081 Clinical Trial.

21

PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers.

Kimura M, Higashi Y, Hara K, Noma K, Sasaki S, Nakagawa K, Goto C, Oshima T, Yoshizumi M, Chayama K. Kimura M, et al. Among authors: higashi y. Hypertension. 2003 May;41(5):1106-10. doi: 10.1161/01.HYP.0000068202.42431.CC. Epub 2003 Apr 14. Hypertension. 2003. PMID: 12695418 Clinical Trial.

22

Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia.

Sanada M, Higashi Y, Nakagawa K, Kodama I, Tsuda M, Nagai N, Chayama K, Ohama K. Sanada M, et al. Among authors: higashi y. Maturitas. 2003 Apr 25;44(4):307-15. doi: 10.1016/s0378-5122(03)00045-8. Maturitas. 2003. PMID: 12697372

23

Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress.

Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, Kawamura M, Chayama K, Yoshizumi M, Nara I. Goto C, et al. Among authors: higashi y. Circulation. 2003 Aug 5;108(5):530-5. doi: 10.1161/01.CIR.0000080893.55729.28. Epub 2003 Jul 21. Circulation. 2003. PMID: 12874192

24

Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress.

Higashi Y, Sasaki S, Nakagawa K, Kimura M, Noma K, Sasaki S, Hara K, Matsuura H, Goto C, Oshima T, Chayama K, Yoshizumi M. Higashi Y, et al. J Am Coll Cardiol. 2003 Jul 16;42(2):256-63. doi: 10.1016/s0735-1097(03)00630-2. J Am Coll Cardiol. 2003. PMID: 12875761 Free article.

25

Myocardial bridging increases the risk of coronary spasm.

Teragawa H, Fukuda Y, Matsuda K, Hirao H, Higashi Y, Yamagata T, Oshima T, Matsuura H, Chayama K. Teragawa H, et al. Among authors: higashi y. Clin Cardiol. 2003 Aug;26(8):377-83. doi: 10.1002/clc.4950260806. Clin Cardiol. 2003. PMID: 12918640 Free PMC article.

26

Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries.

Matsuda K, Teragawa H, Fukuda Y, Ueda K, Higashi Y, Sakai K, Miura F, Hirao H, Yamagata T, Yoshizumi M, Chayama K. Matsuda K, et al. Among authors: higashi y. Am J Cardiol. 2003 Dec 15;92(12):1394-8. doi: 10.1016/j.amjcard.2003.08.043. Am J Cardiol. 2003. PMID: 14675572

27

Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia.

Higashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, Nakagawa K, Oshima T, Chayama K, Sueda T, Goto C, Matsubara H, Murohara T, Yoshizumi M. Higashi Y, et al. Circulation. 2004 Mar 16;109(10):1215-8. doi: 10.1161/01.CIR.0000121427.53291.78. Epub 2004 Mar 8. Circulation. 2004. PMID: 15007007 Clinical Trial.

28

Relation between C reactive protein concentrations and coronary microvascular endothelial function.

Teragawa H, Fukuda Y, Matsuda K, Ueda K, Higashi Y, Oshima T, Yoshizumi M, Chayama K. Teragawa H, et al. Among authors: higashi y. Heart. 2004 Jul;90(7):750-4. doi: 10.1136/hrt.2003.022269. Heart. 2004. PMID: 15201242 Free PMC article.

29

Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.

Jitsuiki D, Higashi Y, Goto C, Kimura M, Noma K, Hara K, Nakagawa K, Oshima T, Chayama K, Yoshizumi M. Jitsuiki D, et al. Among authors: higashi y. Am J Cardiol. 2004 Oct 15;94(8):1070-3. doi: 10.1016/j.amjcard.2004.06.072. Am J Cardiol. 2004. PMID: 15476630

30

Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women.

Tsuda M, Sanada M, Higashi Y, Hara Y, Kodama I, Chayama K, Yoshizumi M, Ohama K. Tsuda M, et al. Among authors: higashi y. Clin Endocrinol (Oxf). 2004 Nov;61(5):619-25. doi: 10.1111/j.1365-2265.2004.02145.x. Clin Endocrinol (Oxf). 2004. PMID: 15521966

31

Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities.

Sanada H, Higashi Y, Goto C, Chayama K, Yoshizumi M, Sueda T. Sanada H, et al. Among authors: higashi y. Atherosclerosis. 2005 Jan;178(1):179-85. doi: 10.1016/j.atherosclerosis.2004.08.013. Atherosclerosis. 2005. PMID: 15585216

32

The nicorandil-induced vasodilation in humans is inhibited by miconazole.

Ueda K, Goto C, Jitsuiki D, Umemura T, Nishioka K, Kimura M, Noma K, Nakagawa K, Oshima T, Yoshizumi M, Chayama K, Higashi Y. Ueda K, et al. Among authors: higashi y. J Cardiovasc Pharmacol. 2005 Apr;45(4):290-4. doi: 10.1097/01.fjc.0000155382.06799.20. J Cardiovasc Pharmacol. 2005. PMID: 15772515

33

Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects.

Oshima T, Ozono R, Yano Y, Oishi Y, Teragawa H, Higashi Y, Yoshizumi M, Kambe M. Oshima T, et al. Among authors: higashi y. J Am Coll Cardiol. 2005 Apr 19;45(8):1219-22. doi: 10.1016/j.jacc.2005.01.019. J Am Coll Cardiol. 2005. PMID: 15837252 Free article.

34

Angiotensin II type I receptor blocker and endothelial function in humans: role of nitric oxide and oxidative stress.

Higashi Y, Chayama K, Yoshizumi M. Higashi Y, et al. Curr Med Chem Cardiovasc Hematol Agents. 2005 Apr;3(2):133-48. doi: 10.2174/1568016053544363. Curr Med Chem Cardiovasc Hematol Agents. 2005. PMID: 15853700 Review.

35

Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production.

Higashi Y, Sasaki S, Nakagawa K, Kimura M, Noma K, Hara K, Jitsuiki D, Goto C, Oshima T, Chayama K, Yoshizumi M. Higashi Y, et al. Atherosclerosis. 2006 Jun;186(2):390-5. doi: 10.1016/j.atherosclerosis.2005.07.025. Epub 2005 Aug 29. Atherosclerosis. 2006. PMID: 16129443

36

Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis.

Ueda K, Teragawa H, Kimura M, Matsuda K, Higashi Y, Yamagata T, Oshima T, Yoshizumi M, Chayama K. Ueda K, et al. Among authors: higashi y. J Cardiovasc Pharmacol. 2005 Oct;46(4):534-9. doi: 10.1097/01.fjc.0000179156.51985.db. J Cardiovasc Pharmacol. 2005. PMID: 16160609 Clinical Trial.

37

Smoking, endothelial function, and Rho-kinase in humans.

Noma K, Goto C, Nishioka K, Hara K, Kimura M, Umemura T, Jitsuiki D, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Higashi Y. Noma K, et al. Among authors: higashi y. Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2630-5. doi: 10.1161/01.ATV.0000189304.32725.bd. Epub 2005 Oct 6. Arterioscler Thromb Vasc Biol. 2005. PMID: 16210569

38

Relationship between endothelial function in the coronary and brachial arteries.

Teragawa H, Ueda K, Matsuda K, Kimura M, Higashi Y, Oshima T, Yoshizumi M, Chayama K. Teragawa H, et al. Among authors: higashi y. Clin Cardiol. 2005 Oct;28(10):460-6. doi: 10.1002/clc.4960281004. Clin Cardiol. 2005. PMID: 16274093 Free PMC article.

39

Oxidative stress, endothelial function and angiogenesis induced by cell therapy and gene therapy.

Higashi Y, Nishioka K, Umemura T, Chayama K, Yoshizumi M. Higashi Y, et al. Curr Pharm Biotechnol. 2006 Apr;7(2):109-16. doi: 10.2174/138920106776597658. Curr Pharm Biotechnol. 2006. PMID: 16724945 Review.

40

Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome.

Umemura T, Nishioka K, Igarashi A, Kato Y, Ochi M, Chayama K, Yoshizumi M, Higashi Y. Umemura T, et al. Among authors: higashi y. Circ J. 2006 Oct;70(10):1362-4. doi: 10.1253/circj.70.1362. Circ J. 2006. PMID: 16998273 Free article.

41

Effects of acute administration of caffeine on vascular function.

Umemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Soga J, Goto C, Chayama K, Yoshizumi M, Higashi Y. Umemura T, et al. Among authors: higashi y. Am J Cardiol. 2006 Dec 1;98(11):1538-41. doi: 10.1016/j.amjcard.2006.06.058. Epub 2006 Oct 16. Am J Cardiol. 2006. PMID: 17126666 Clinical Trial.

42

Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy.

Nishioka K, Nakagawa K, Umemura T, Jitsuiki D, Ueda K, Goto C, Chayama K, Yoshizumi M, Higashi Y. Nishioka K, et al. Among authors: higashi y. Heart. 2007 Feb;93(2):247-8. doi: 10.1136/hrt.2006.087999. Heart. 2007. PMID: 17228074 Free PMC article. Clinical Trial. No abstract available.

43

Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.

Noma K, Goto C, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y. Noma K, et al. Among authors: higashi y. J Am Coll Cardiol. 2007 Feb 13;49(6):698-705. doi: 10.1016/j.jacc.2006.06.082. Epub 2007 Jan 26. J Am Coll Cardiol. 2007. PMID: 17291936 Free PMC article.

44

Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease.

Miyazaki M, Higashi Y, Goto C, Chayama K, Yoshizumi M, Sanada H, Orihashi K, Sueda T. Miyazaki M, et al. Among authors: higashi y. J Cardiovasc Pharmacol. 2007 Apr;49(4):221-7. doi: 10.1097/FJC.0b013e3180325af3. J Cardiovasc Pharmacol. 2007. PMID: 17438407 Clinical Trial.

45

Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells.

Kimura M, Ueda K, Goto C, Jitsuiki D, Nishioka K, Umemura T, Noma K, Yoshizumi M, Chayama K, Higashi Y. Kimura M, et al. Among authors: higashi y. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1403-10. doi: 10.1161/ATVBAHA.107.143578. Epub 2007 Apr 19. Arterioscler Thromb Vasc Biol. 2007. PMID: 17446439 Clinical Trial.

46

Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions.

Soga J, Nishioka K, Nakamura S, Umemura T, Jitsuiki D, Hidaka T, Teragawa H, Takemoto H, Goto C, Yoshizumi M, Chayama K, Higashi Y. Soga J, et al. Among authors: higashi y. Circ J. 2007 May;71(5):736-40. doi: 10.1253/circj.71.736. Circ J. 2007. PMID: 17457001 Free article.

47

Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans.

Goto C, Nishioka K, Umemura T, Jitsuiki D, Sakagutchi A, Kawamura M, Chayama K, Yoshizumi M, Higashi Y. Goto C, et al. Among authors: higashi y. Am J Hypertens. 2007 Aug;20(8):825-30. doi: 10.1016/j.amjhyper.2007.02.014. Am J Hypertens. 2007. PMID: 17679027

48

Images in cardiovascular medicine. Corkscrew collaterals in thromboangitis obliterans (Buerger's disease).

Fujii Y, Nishioka K, Yoshizumi M, Chayama K, Higashi Y. Fujii Y, et al. Among authors: higashi y. Circulation. 2007 Nov 20;116(21):e539-40. doi: 10.1161/CIRCULATIONAHA.107.728717. Circulation. 2007. PMID: 18025397 No abstract available.

49

Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans.

Nishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D, Soga J, Goto C, Chayama K, Yoshizumi M, Higashi Y. Nishioka K, et al. Among authors: higashi y. Hypertens Res. 2007 Sep;30(9):775-80. doi: 10.1291/hypres.30.775. Hypertens Res. 2007. PMID: 18037769 Clinical Trial.

50

Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients.

Higashi Y, Goto C, Jitsuiki D, Umemura T, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Soga J, Chayama K, Yoshizumi M, Taguchi A. Higashi Y, et al. Hypertension. 2008 Feb;51(2):446-53. doi: 10.1161/HYPERTENSIONAHA.107.101535. Epub 2007 Nov 26. Hypertension. 2008. PMID: 18039979

51

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases.

Higashi Y, Jitsuiki D, Chayama K, Yoshizumi M. Higashi Y, et al. Recent Pat Cardiovasc Drug Discov. 2006 Jan;1(1):85-93. doi: 10.2174/157489006775244191. Recent Pat Cardiovasc Drug Discov. 2006. PMID: 18221078 Review.

52

Coronary vasospasm produces reversible perfusion defects observed during adenosine triphosphate stress myocardial single-photon emission computed tomography.

Teragawa H, Ueda K, Okuhara K, Kuwashima R, Fukuda Y, Kiguchi M, Taniguchi K, Higashi Y, Oshima T, Yoshizumi M, Chayama K. Teragawa H, et al. Among authors: higashi y. Clin Cardiol. 2008 Jul;31(7):310-6. doi: 10.1002/clc.20217. Clin Cardiol. 2008. PMID: 18636477 Free PMC article.

53

Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.

Umemura T, Soga J, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Nishioka K, Goto C, Teragawa H, Yoshizumi M, Chayama K, Higashi Y. Umemura T, et al. Among authors: higashi y. Am J Hypertens. 2008 Nov;21(11):1203-9. doi: 10.1038/ajh.2008.278. Epub 2008 Sep 11. Am J Hypertens. 2008. PMID: 18787520

54

Relationship between augmentation index and flow-mediated vasodilation in the brachial artery.

Soga J, Nakamura S, Nishioka K, Umemura T, Jitsuiki D, Hidaka T, Teragawa H, Takemoto H, Goto C, Yoshizumi M, Chayama K, Higashi Y. Soga J, et al. Among authors: higashi y. Hypertens Res. 2008 Jul;31(7):1293-8. doi: 10.1291/hypres.31.1293. Hypertens Res. 2008. PMID: 18957798

55

Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation.

Nakamura S, Kimura M, Goto C, Noma K, Yoshizumi M, Chayama K, Kihara Y, Higashi Y. Nakamura S, et al. Among authors: higashi y. Hypertension. 2009 Apr;53(4):674-81. doi: 10.1161/HYPERTENSIONAHA.108.126078. Epub 2009 Feb 23. Hypertension. 2009. PMID: 19237681 Clinical Trial.

56

Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease.

Higashi Y, Goto C, Hidaka T, Soga J, Nakamura S, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Taguchi A. Higashi Y, et al. Atherosclerosis. 2009 Oct;206(2):604-10. doi: 10.1016/j.atherosclerosis.2009.03.037. Epub 2009 Apr 5. Atherosclerosis. 2009. PMID: 19410250 Free article.

57

Sarpogrelate hydrochloride, a selective 5-hydroxytryptamine(2A) antagonist, augments autologous bone marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia.

Higashi Y, Miyazaki M, Goto C, Sanada H, Sueda T, Chayama K. Higashi Y, et al. J Cardiovasc Pharmacol. 2010 Jan;55(1):56-61. doi: 10.1097/FJC.0b013e3181c37da4. J Cardiovasc Pharmacol. 2010. PMID: 19834330 Free article. Clinical Trial.

58

Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells.

Higashi Y, Matsuoka H, Umei H, Sugano R, Fujii Y, Soga J, Kihara Y, Chayama K, Imaizumi T. Higashi Y, et al. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E202-9. doi: 10.1152/ajpendo.00394.2009. Epub 2009 Nov 10. Am J Physiol Endocrinol Metab. 2010. PMID: 19903864 Free article. Clinical Trial.

59

Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress.

Hidaka T, Nakagawa K, Goto C, Soga J, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Higashi Y. Hidaka T, et al. Among authors: higashi y. Atherosclerosis. 2010 Jun;210(2):521-4. doi: 10.1016/j.atherosclerosis.2009.12.011. Epub 2010 Jan 4. Atherosclerosis. 2010. PMID: 20064642

60

Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers.

Hidaka T, Hata T, Soga J, Fujii Y, Idei N, Fujimura N, Kihara Y, Noma K, Liao JK, Higashi Y. Hidaka T, et al. Among authors: higashi y. Hypertens Res. 2010 Apr;33(4):354-9. doi: 10.1038/hr.2010.3. Epub 2010 Feb 5. Hypertens Res. 2010. PMID: 20139919 Free PMC article.

61

Mesenchymal stem cells enhance growth and metastasis of colon cancer.

Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Kodama M, Higashi Y, Tanaka S, Yasui W, Chayama K. Shinagawa K, et al. Among authors: higashi y. Int J Cancer. 2010 Nov 15;127(10):2323-33. doi: 10.1002/ijc.25440. Int J Cancer. 2010. PMID: 20473928 Free article.

62

Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers.

Fujii Y, Soga J, Nakamura S, Hidaka T, Hata T, Idei N, Fujimura N, Nishioka K, Chayama K, Kihara Y, Higashi Y. Fujii Y, et al. Among authors: higashi y. Circ J. 2010 Aug;74(8):1684-8. doi: 10.1253/circj.cj-09-0878. Epub 2010 Jun 9. Circ J. 2010. PMID: 20534945 Free article.

63

Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.

Hata T, Goto C, Soga J, Hidaka T, Fujii Y, Idei N, Fujimura N, Maruhashi T, Mikami S, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y. Hata T, et al. Among authors: higashi y. Atherosclerosis. 2011 Jan;214(1):117-21. doi: 10.1016/j.atherosclerosis.2010.10.005. Epub 2010 Oct 12. Atherosclerosis. 2011. PMID: 21035804 Free PMC article.

64

Calcium channel blocker and Rho-associated kinase activity in patients with hypertension.

Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y; ROCK Study Group. Hata T, et al. Among authors: higashi y. J Hypertens. 2011 Feb;29(2):373-9. doi: 10.1097/HJH.0b013e328340902d. J Hypertens. 2011. PMID: 21063203 Free PMC article. Clinical Trial.

65

Vascular function and circulating progenitor cells in thromboangitis obliterans (Buerger's disease) and atherosclerosis obliterans.

Idei N, Nishioka K, Soga J, Hidaka T, Hata T, Fujii Y, Fujimura N, Maruhashi T, Mikami S, Teragawa H, Kihara Y, Noma K, Chayama K, Higashi Y. Idei N, et al. Among authors: higashi y. Hypertension. 2011 Jan;57(1):70-8. doi: 10.1161/HYPERTENSIONAHA.110.163683. Epub 2010 Nov 29. Hypertension. 2011. PMID: 21115876

66

Impaired coronary microvascular endothelial function in men with metabolic syndrome.

Teragawa H, Mitsuba N, Nishioka K, Ueda K, Kono S, Higashi Y, Chayama K, Kihara Y. Teragawa H, et al. Among authors: higashi y. World J Cardiol. 2010 Jul 26;2(7):205-10. doi: 10.4330/wjc.v2.i7.205. World J Cardiol. 2010. PMID: 21160752 Free PMC article.

67

Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia: a comparison of atherosclerotic peripheral arterial disease and Buerger disease.

Idei N, Soga J, Hata T, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Nishioka K, Hidaka T, Kihara Y, Chowdhury M, Noma K, Taguchi A, Chayama K, Sueda T, Higashi Y. Idei N, et al. Among authors: higashi y. Circ Cardiovasc Interv. 2011 Feb 1;4(1):15-25. doi: 10.1161/CIRCINTERVENTIONS.110.955724. Epub 2011 Jan 4. Circ Cardiovasc Interv. 2011. PMID: 21205941 Clinical Trial.

68

Color doppler flows of corkscrew collaterals in Thromboangiitis obliterans (Buerger's disease) using color duplex ultrasonography.

Fujii Y, Soga J, Hidaka T, Hata T, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Noma K, Higashi Y. Fujii Y, et al. Among authors: higashi y. J Am Coll Cardiol. 2011 Jun 21;57(25):2539. doi: 10.1016/j.jacc.2010.07.071. J Am Coll Cardiol. 2011. PMID: 21679855 Free article. No abstract available.

69

Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.

Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y; ROCK Study Group. Soga J, et al. Among authors: higashi y. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2353-9. doi: 10.1161/ATVBAHA.111.227892. Epub 2011 Jul 7. Arterioscler Thromb Vasc Biol. 2011. PMID: 21737782 Free PMC article.

70

Flow-mediated vasodilation is augmented in a corkscrew collateral artery compared with that in a native artery in patients with thromboangiitis obliterans (Buerger disease).

Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Noma K, Higashi Y. Fujii Y, et al. Among authors: higashi y. J Vasc Surg. 2011 Dec;54(6):1689-97. doi: 10.1016/j.jvs.2011.05.095. Epub 2011 Sep 9. J Vasc Surg. 2011. PMID: 21908145 Free article.

71

Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans.

Fujimura N, Jitsuiki D, Maruhashi T, Mikami S, Iwamoto Y, Kajikawa M, Chayama K, Kihara Y, Noma K, Goto C, Higashi Y. Fujimura N, et al. Among authors: higashi y. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):153-60. doi: 10.1161/ATVBAHA.111.237263. Epub 2011 Oct 13. Arterioscler Thromb Vasc Biol. 2012. PMID: 21998134

72

Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension.

Fujimura N, Noma K, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y; ROCK Study Group. Fujimura N, et al. Among authors: higashi y. Clin Pharmacol Ther. 2012 Feb;91(2):289-97. doi: 10.1038/clpt.2011.227. Epub 2011 Dec 28. Clin Pharmacol Ther. 2012. PMID: 22205191 Free PMC article. Clinical Trial.

73

Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Circulation. 2012 Jul 31;126(5):598-603. doi: 10.1161/CIRCULATIONAHA.112.105775. Epub 2012 Jul 6. Circulation. 2012. PMID: 22773454

74

Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors.

Iwamoto Y, Maruhashi T, Fujii Y, Idei N, Fujimura N, Mikami S, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Higashi Y. Iwamoto Y, et al. Among authors: higashi y. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2295-303. doi: 10.1161/ATVBAHA.112.249680. Epub 2012 Jul 12. Arterioscler Thromb Vasc Biol. 2012. PMID: 22796580

75

Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer.

Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Onoyama M, Ohnishi M, Ohara E, Higashi Y, Tanaka S, Yasui W, Chayama K. Shinagawa K, et al. Among authors: higashi y. Int J Cancer. 2013 Feb 15;132(4):813-23. doi: 10.1002/ijc.27735. Epub 2012 Aug 6. Int J Cancer. 2013. PMID: 22821812 Free article.

76

Endothelial dysfunction and hypertension in aging.

Higashi Y, Kihara Y, Noma K. Higashi Y, et al. Hypertens Res. 2012 Nov;35(11):1039-47. doi: 10.1038/hr.2012.138. Epub 2012 Sep 13. Hypertens Res. 2012. PMID: 22972557 Review.

77

Flow-mediated vasodilation and anatomical variation of the brachial artery (double brachial artery) in healthy subjects and patients with cardiovascular disease.

Fujii Y, Teragawa H, Soga J, Idei N, Fujimura N, Maruhashi T, Mikami S, Iwamoto Y, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y. Fujii Y, et al. Among authors: higashi y. Circ J. 2013;77(4):1073-80. doi: 10.1253/circj.cj-12-1130. Epub 2012 Dec 7. Circ J. 2013. PMID: 23220859 Free article. Clinical Trial.

78

Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling.

Ueno T, Nakashima A, Doi S, Kawamoto T, Honda K, Yokoyama Y, Doi T, Higashi Y, Yorioka N, Kato Y, Kohno N, Masaki T. Ueno T, et al. Among authors: higashi y. Kidney Int. 2013 Aug;84(2):297-307. doi: 10.1038/ki.2013.81. Epub 2013 Mar 13. Kidney Int. 2013. PMID: 23486522 Free PMC article.

79

Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1401-8. doi: 10.1161/ATVBAHA.112.300934. Epub 2013 Mar 21. Arterioscler Thromb Vasc Biol. 2013. PMID: 23520168

80

Autologous bone-marrow mesenchymal stem cell implantation and endothelial function in a rabbit ischemic limb model.

Mikami S, Nakashima A, Nakagawa K, Maruhashi T, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Ochi M, Nishimura M, Tsuji K, Kato Y, Goto C, Higashi Y. Mikami S, et al. Among authors: higashi y. PLoS One. 2013 Jul 4;8(7):e67739. doi: 10.1371/journal.pone.0067739. Print 2013. PLoS One. 2013. PMID: 23861797 Free PMC article.

81

A novel noninvasive and simple method for assessment of endothelial function: enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement.

Idei N, Ukawa T, Kajikawa M, Iwamoto Y, Fujimura N, Maruhashi T, Mikami S, Matsumoto T, Kihara Y, Chayama K, Noma K, Nakashima A, Takayanagi T, Morimoto H, Tsuji T, Higashi Y. Idei N, et al. Among authors: higashi y. Atherosclerosis. 2013 Aug;229(2):324-30. doi: 10.1016/j.atherosclerosis.2013.05.016. Epub 2013 Jun 6. Atherosclerosis. 2013. PMID: 23880183 Free article. Clinical Trial.

82

Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Yamashina A, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Heart. 2013 Dec;99(24):1837-42. doi: 10.1136/heartjnl-2013-304739. Epub 2013 Oct 23. Heart. 2013. PMID: 24153417 Free PMC article.

83

Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women.

Maruhashi T, Nakashima A, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y. Maruhashi T, et al. Among authors: higashi y. BMJ Open. 2013 Nov 8;3(11):e003659. doi: 10.1136/bmjopen-2013-003659. BMJ Open. 2013. PMID: 24213096 Free PMC article.

84

Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications.

Higashi Y, Maruhashi T, Noma K, Kihara Y. Higashi Y, et al. Trends Cardiovasc Med. 2014 May;24(4):165-9. doi: 10.1016/j.tcm.2013.12.001. Epub 2013 Dec 4. Trends Cardiovasc Med. 2014. PMID: 24373981 Review.

85

Rho-associated kinase activity is a predictor of cardiovascular outcomes.

Kajikawa M, Noma K, Maruhashi T, Mikami S, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Hypertension. 2014 Apr;63(4):856-64. doi: 10.1161/HYPERTENSIONAHA.113.02296. Epub 2013 Dec 30. Hypertension. 2014. PMID: 24379190 Free PMC article.

86

Poor oral health, that is, decreased frequency of tooth brushing, is associated with endothelial dysfunction.

Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Goto C, Taguchi A, Noma K, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Circ J. 2014;78(4):950-4. doi: 10.1253/circj.cj-13-1330. Epub 2014 Feb 5. Circ J. 2014. PMID: 24500034 Free article. Clinical Trial.

87

Borderline ankle-brachial index value of 0.91-0.99 is associated with endothelial dysfunction.

Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Noma K, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Circ J. 2014;78(7):1740-5. doi: 10.1253/circj.cj-14-0165. Epub 2014 May 10. Circ J. 2014. PMID: 24813179 Free article.

88

Relationship between nitroglycerine-induced vasodilation and clinical severity of peripheral artery disease.

Maruhashi T, Nakashima A, Matsumoto T, Oda N, Iwamoto Y, Iwamoto A, Kajikawa M, Kihara Y, Chayama K, Goto C, Noma K, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Atherosclerosis. 2014 Jul;235(1):65-70. doi: 10.1016/j.atherosclerosis.2014.04.012. Epub 2014 Apr 26. Atherosclerosis. 2014. PMID: 24816039

89

Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.

Maruhashi T, Noma K, Iwamoto Y, Iwamoto A, Oda N, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y. Maruhashi T, et al. Among authors: higashi y. PLoS One. 2014 Oct 3;9(10):e109017. doi: 10.1371/journal.pone.0109017. eCollection 2014. PLoS One. 2014. PMID: 25280018 Free PMC article.

90

Ratio of serum levels of AGEs to soluble form of RAGE is a predictor of endothelial function.

Kajikawa M, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Oda N, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Noma K, Takeuchi M, Matsui T, Yamagishi S, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Diabetes Care. 2015 Jan;38(1):119-25. doi: 10.2337/dc14-1435. Epub 2014 Oct 21. Diabetes Care. 2015. PMID: 25336748

91

Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism.

Matsumoto T, Oki K, Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Hidaka T, Kihara Y, Kohno N, Chayama K, Goto C, Aibara Y, Noma K, Liao JK, Higashi Y. Matsumoto T, et al. Among authors: higashi y. Hypertension. 2015 Apr;65(4):841-8. doi: 10.1161/HYPERTENSIONAHA.114.05001. Epub 2015 Jan 26. Hypertension. 2015. PMID: 25624340 Free PMC article.

92

Endothelial dysfunction is associated with the severity of cerebral small vessel disease.

Nezu T, Hosomi N, Aoki S, Kubo S, Araki M, Mukai T, Takahashi T, Maruyama H, Higashi Y, Matsumoto M. Nezu T, et al. Among authors: higashi y. Hypertens Res. 2015 Apr;38(4):291-7. doi: 10.1038/hr.2015.4. Epub 2015 Feb 12. Hypertens Res. 2015. PMID: 25672660

93

Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial.

Maruhashi T, Noma K, Fujimura N, Kajikawa M, Matsumoto T, Hidaka T, Nakashima A, Kihara Y, Liao JK, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Hypertens Res. 2015 Jul;38(7):485-90. doi: 10.1038/hr.2015.24. Epub 2015 Mar 5. Hypertens Res. 2015. PMID: 25740292 Free PMC article. Clinical Trial.

94

Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome.

Kajikawa M, Noma K, Nakashima A, Maruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Hidaka T, Kihara Y, Aibara Y, Chayama K, Sasaki S, Kato M, Dote K, Goto C, Liao JK, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Hypertension. 2015 Oct;66(4):892-9. doi: 10.1161/HYPERTENSIONAHA.115.05587. Epub 2015 Aug 17. Hypertension. 2015. PMID: 26283039 Free PMC article.

95

Reduction in blood pressure improves impaired nitroglycerine-induced vasodilation in patients with essential hypertension.

Maruhashi T, Nakashima A, Kishimoto S, Iwamoto A, Kajikawa M, Oda N, Kihara Y, Aibara Y, Noma K, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Hypertens Res. 2015 Dec;38(12):862-8. doi: 10.1038/hr.2015.93. Epub 2015 Sep 3. Hypertens Res. 2015. PMID: 26333358

96

Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma.

Takigawa H, Kitadai Y, Shinagawa K, Yuge R, Higashi Y, Tanaka S, Yasui W, Chayama K. Takigawa H, et al. Among authors: higashi y. Cancer Sci. 2016 May;107(5):601-8. doi: 10.1111/cas.12907. Epub 2016 Mar 18. Cancer Sci. 2016. PMID: 26865419 Free PMC article.

97

Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events.

Kajikawa M, Maruhashi T, Hida E, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Kishimoto S, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Hypertension. 2016 May;67(5):1045-52. doi: 10.1161/HYPERTENSIONAHA.115.06839. Epub 2016 Mar 14. Hypertension. 2016. PMID: 26975705

98

Relationship between serum triglyceride levels and endothelial function in a large community-based study.

Kajikawa M, Maruhashi T, Matsumoto T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Aibara Y, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y. Kajikawa M, et al. Among authors: higashi y. Atherosclerosis. 2016 Jun;249:70-5. doi: 10.1016/j.atherosclerosis.2016.03.035. Epub 2016 Apr 1. Atherosclerosis. 2016. PMID: 27065244

99

Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease.

Iwamoto A, Kajikawa M, Maruhashi T, Iwamoto Y, Oda N, Kishimoto S, Matsui S, Kihara Y, Chayama K, Goto C, Noma K, Aibara Y, Nakashima A, Higashi Y. Iwamoto A, et al. Among authors: higashi y. J Atheroscler Thromb. 2016 Nov 1;23(11):1261-1269. doi: 10.5551/jat.35436. Epub 2016 May 9. J Atheroscler Thromb. 2016. PMID: 27169920 Free PMC article.

100

Nitroglycerine-induced vasodilation in coronary and brachial arteries in patients with suspected coronary artery disease.

Maruhashi T, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Higaki T, Shimonaga T, Watanabe N, Ikenaga H, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Noma K, Higashi Y. Maruhashi T, et al. Among authors: higashi y. Int J Cardiol. 2016 Sep 15;219:312-6. doi: 10.1016/j.ijcard.2016.06.050. Epub 2016 Jun 15. Int J Cardiol. 2016. PMID: 27344131

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