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A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11 years with cystic fibrosis.
Walker S, Flume P, McNamara J, Solomon M, Chilvers M, Chmiel J, Harris RS, Haseltine E, Stiles D, Li C, Ahluwalia N, Zhou H, Owen CA, Sawicki G; VX15-661-113 Investigator Group. Walker S, et al. Among authors: owen ca. J Cyst Fibros. 2019 Sep;18(5):708-713. doi: 10.1016/j.jcf.2019.06.009. Epub 2019 Jun 26. J Cyst Fibros. 2019. PMID: 31253540 Free article. Clinical Trial.
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Among authors: owen ca. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Long-term safety of lumacaftor-ivacaftor in children aged 2-5 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a multicentre, phase 3, open-label, extension study.
Hoppe JE, Chilvers M, Ratjen F, McNamara JJ, Owen CA, Tian S, Zahigian R, Cornell AG, McColley SA. Hoppe JE, et al. Among authors: owen ca. Lancet Respir Med. 2021 Sep;9(9):977-988. doi: 10.1016/S2213-2600(21)00069-2. Epub 2021 May 6. Lancet Respir Med. 2021. PMID: 33965000
Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2-5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study.
McNamara JJ, McColley SA, Marigowda G, Liu F, Tian S, Owen CA, Stiles D, Li C, Waltz D, Wang LT, Sawicki GS. McNamara JJ, et al. Among authors: owen ca. Lancet Respir Med. 2019 Apr;7(4):325-335. doi: 10.1016/S2213-2600(18)30460-0. Epub 2019 Jan 24. Lancet Respir Med. 2019. PMID: 30686767 Clinical Trial.
A phase 3, double-blind, parallel-group study to evaluate the efficacy and safety of tezacaftor in combination with ivacaftor in participants 6 through 11 years of age with cystic fibrosis homozygous for F508del or heterozygous for the F508del-CFTR mutation and a residual function mutation.
Davies JC, Sermet-Gaudelus I, Naehrlich L, Harris RS, Campbell D, Ahluwalia N, Short C, Haseltine E, Panorchan P, Saunders C, Owen CA, Wainwright CE; VX16-661-115 Investigator Group. Davies JC, et al. Among authors: owen ca. J Cyst Fibros. 2021 Jan;20(1):68-77. doi: 10.1016/j.jcf.2020.07.023. Epub 2020 Sep 21. J Cyst Fibros. 2021. PMID: 32967799 Free article. Clinical Trial.
A phase 3, randomized, double-blind, parallel-group study to evaluate tezacaftor/ivacaftor in people with cystic fibrosis heterozygous for F508del-CFTR and a gating mutation.
McKone EF, DiMango EA, Sutharsan S, Barto TL, Campbell D, Ahluwalia N, Higgins M, Owen CA, Tullis E. McKone EF, et al. Among authors: owen ca. J Cyst Fibros. 2021 Mar;20(2):234-242. doi: 10.1016/j.jcf.2020.11.003. Epub 2020 Dec 16. J Cyst Fibros. 2021. PMID: 33339768 Free article. Clinical Trial.
Long-term safety and efficacy of lumacaftor-ivacaftor therapy in children aged 6-11 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a phase 3, open-label, extension study.
Chilvers MA, Davies JC, Milla C, Tian S, Han Z, Cornell AG, Owen CA, Ratjen F. Chilvers MA, et al. Among authors: owen ca. Lancet Respir Med. 2021 Jul;9(7):721-732. doi: 10.1016/S2213-2600(20)30517-8. Epub 2021 Jan 28. Lancet Respir Med. 2021. PMID: 33516285 Clinical Trial.
CFTR regulates B cell activation and lymphoid follicle development.
Polverino F, Lu B, Quintero JR, Vargas SO, Patel AS, Owen CA, Gerard NP, Gerard C, Cernadas M. Polverino F, et al. Among authors: owen ca. Respir Res. 2019 Jul 1;20(1):133. doi: 10.1186/s12931-019-1103-1. Respir Res. 2019. PMID: 31262295 Free PMC article.
Dusting Off IL-9 as a New Therapeutic Target for Pulmonary Fibrosis.
Rojas-Quintero J, Wang X, Owen CA. Rojas-Quintero J, et al. Among authors: owen ca. Am J Respir Cell Mol Biol. 2019 Feb;60(2):141-143. doi: 10.1165/rcmb.2018-0319ED. Am J Respir Cell Mol Biol. 2019. PMID: 30281328 Free PMC article. No abstract available.
Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype.
Celli BR, Locantore N, Tal-Singer R, Riley J, Miller B, Vestbo J, Yates JC, Silverman EK, Owen CA, Divo M, Pinto-Plata V, Wouters EFM, Faner R, Agusti A; ECLIPSE Study Investigators. Celli BR, et al. Among authors: owen ca. Eur Respir J. 2018 Feb 7;51(2):1702146. doi: 10.1183/13993003.02146-2017. Print 2018 Feb. Eur Respir J. 2018. PMID: 29437944 Free article.
Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.
Almeida-Reis R, Theodoro-Junior OA, Oliveira BTM, Oliva LV, Toledo-Arruda AC, Bonturi CR, Brito MV, Lopes FDTQS, Prado CM, Florencio AC, Martins MA, Owen CA, Leick EA, Oliva MLV, Tibério IFLC. Almeida-Reis R, et al. Among authors: owen ca. Biomed Res Int. 2017;2017:8287125. doi: 10.1155/2017/8287125. Epub 2017 Mar 30. Biomed Res Int. 2017. PMID: 28466019 Free PMC article.
Hhip haploinsufficiency sensitizes mice to age-related emphysema.
Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Lao T, et al. Among authors: owen ca. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7. doi: 10.1073/pnas.1602342113. Epub 2016 Jul 21. Proc Natl Acad Sci U S A. 2016. PMID: 27444019 Free PMC article.
Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.
Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC. Tejera P, et al. Among authors: owen ca. Am J Respir Cell Mol Biol. 2014 Aug;51(2):262-72. doi: 10.1165/rcmb.2013-0238OC. Am J Respir Cell Mol Biol. 2014. PMID: 24617927 Free PMC article.
Idiopathic pulmonary fibrosis and coronary artery disease.
Cicchitto G, Musella V, Acitorio M, Capuano N, Fiorenzano G, Owen CA, Polverino M, Polverino F. Cicchitto G, et al. Among authors: owen ca. Multidiscip Respir Med. 2014 May 30;9(1):31. doi: 10.1186/2049-6958-9-31. eCollection 2014. Multidiscip Respir Med. 2014. PMID: 24976970 Free PMC article.
ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction.
Wang X, Zhang D, Higham A, Wolosianka S, Gai X, Zhou L, Petersen H, Pinto-Plata V, Divo M, Silverman EK, Celli B, Singh D, Sun Y, Owen CA. Wang X, et al. Among authors: owen ca. Respir Res. 2020 Jul 16;21(1):188. doi: 10.1186/s12931-020-01446-5. Respir Res. 2020. PMID: 32677970 Free PMC article.
ADAM8: a new therapeutic target for asthma.
Knolle MD, Owen CA. Knolle MD, et al. Among authors: owen ca. Expert Opin Ther Targets. 2009 May;13(5):523-40. doi: 10.1517/14728220902889788. Expert Opin Ther Targets. 2009. PMID: 19397475 Free PMC article. Review.
Adam8 limits the development of allergic airway inflammation in mice.
Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Knolle MD, et al. Among authors: owen ca. J Immunol. 2013 Jun 15;190(12):6434-49. doi: 10.4049/jimmunol.1202329. Epub 2013 May 13. J Immunol. 2013. PMID: 23670189 Free PMC article.
Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.
Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP. Yun JH, et al. Among authors: owen ca. Am J Respir Cell Mol Biol. 2017 Jul;57(1):47-58. doi: 10.1165/rcmb.2016-0328OC. Am J Respir Cell Mol Biol. 2017. PMID: 28248572 Free PMC article.
Reply to Voelkel: Cigarette Smoke Is an Endothelial Cell Toxin.
Polverino F, Celli BR, Owen CA. Polverino F, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2018 Jan 15;197(2):274-275. doi: 10.1164/rccm.201707-1381LE. Am J Respir Crit Care Med. 2018. PMID: 28726486 Free PMC article. No abstract available.
The club cell and its protein, CC16: time to shine.
Celli BR, Owen CA. Celli BR, et al. Among authors: owen ca. Lancet Respir Med. 2013 Dec;1(10):757-9. doi: 10.1016/S2213-2600(13)70247-9. Epub 2013 Nov 15. Lancet Respir Med. 2013. PMID: 24461745 No abstract available.
A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature.
Dieffenbach PB, Mallarino Haeger C, Rehman R, Corcoran AM, Coronata AMF, Vellarikkal SK, Chrobak I, Waxman AB, Vitali SH, Sholl LM, Padera RF, Lagares D, Polverino F, Owen CA, Fredenburgh LE. Dieffenbach PB, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2021 Dec 15;204(12):1433-1451. doi: 10.1164/rccm.202108-1863OC. Am J Respir Crit Care Med. 2021. PMID: 34550870 Free PMC article.
Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 - April 1, 2016, Tours, France.
Desoubeaux G, Reichert JM, Sleeman M, Reckamp KL, Ryffel B, Adamczewski JP, Sweeney TD, Vanbever R, Diot P, Owen CA, Page C, Lerondel S, Le Pape A, Heuze-Vourc'h N. Desoubeaux G, et al. Among authors: owen ca. MAbs. 2016 Aug-Sep;8(6):999-1009. doi: 10.1080/19420862.2016.1196521. Epub 2016 Jun 6. MAbs. 2016. PMID: 27266390 Free PMC article.
Gas exchange and breathing pattern in women with postmenopausal bone fragility.
Polverino F, de Torres JP, Santoriello C, Capuozzo A, Mauro I, Rojas-Quintero J, D'Agostino B, Pistolesi M, Celli B, Polverino M, Owen CA. Polverino F, et al. Among authors: owen ca. Respir Med. 2018 Apr;137:141-146. doi: 10.1016/j.rmed.2018.03.006. Epub 2018 Mar 7. Respir Med. 2018. PMID: 29605198 Free article.
ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1.
Umeda M, Yoshida N, Hisada R, Burbano C, Orite SYK, Kono M, Kyttaris VC, Krishfield S, Owen CA, Tsokos GC. Umeda M, et al. Among authors: owen ca. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2023230118. doi: 10.1073/pnas.2023230118. Proc Natl Acad Sci U S A. 2021. PMID: 33911034 Free PMC article.
A novel nonhuman primate model of cigarette smoke-induced airway disease.
Polverino F, Doyle-Eisele M, McDonald J, Wilder JA, Royer C, Laucho-Contreras M, Kelly EM, Divo M, Pinto-Plata V, Mauderly J, Celli BR, Tesfaigzi Y, Owen CA. Polverino F, et al. Among authors: owen ca. Am J Pathol. 2015 Mar;185(3):741-55. doi: 10.1016/j.ajpath.2014.11.006. Epub 2014 Dec 24. Am J Pathol. 2015. PMID: 25542772 Free PMC article.
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.
Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X. Jiang Z, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC. Am J Respir Crit Care Med. 2016. PMID: 26862784 Free PMC article.
Endothelial Cell Death in Emphysema: More Sugarcoating Needed?
Rojas-Quintero J, Wang X, Owen CA. Rojas-Quintero J, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2019 Nov 1;200(9):1078-1080. doi: 10.1164/rccm.201906-1254ED. Am J Respir Crit Care Med. 2019. PMID: 31298928 Free PMC article. No abstract available.
CC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice.
Rojas-Quintero J, Laucho-Contreras ME, Wang X, Fucci QA, Burkett PR, Kim SJ, Zhang D, Tesfaigzi Y, Li Y, Bhashyam AR, Li Z, Khamas H, Celli B, Pilon AL, Polverino F, Owen CA. Rojas-Quintero J, et al. Among authors: owen ca. JCI Insight. 2023 Mar 22;8(6):e130771. doi: 10.1172/jci.insight.130771. JCI Insight. 2023. PMID: 36787195 Free PMC article.
Association of clonal hematopoiesis with chronic obstructive pulmonary disease.
Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, Niroula A, McConkey ME, Sandoval B, Miller BC, Shi W, Viswanathan K, Leventhal M, Werner L, Moll M, Cade BE, Barr RG, Correa A, Cupples LA, Gharib SA, Jain D, Gogarten SM, Lange LA, London SJ, Manichaikul A, O'Connor GT, Oelsner EC, Redline S, Rich SS, Rotter JI, Ramachandran V, Yu B, Sholl L, Neuberg D, Jaiswal S, Levy BD, Owen CA, Natarajan P, Silverman EK, van Galen P, Tesfaigzi Y, Cho MH, Ebert BL; COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium. Miller PG, et al. Among authors: owen ca. Blood. 2022 Jan 20;139(3):357-368. doi: 10.1182/blood.2021013531. Blood. 2022. PMID: 34855941 Free PMC article.
Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.
Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B. Polverino F, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2021 Sep 15;204(6):651-666. doi: 10.1164/rccm.202012-4510OC. Am J Respir Crit Care Med. 2021. PMID: 34033525 Free PMC article.
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Lam HC, et al. Among authors: owen ca. J Clin Invest. 2020 Nov 2;130(11):6189. doi: 10.1172/JCI143863. J Clin Invest. 2020. PMID: 33136096 Free PMC article. No abstract available.
Artificial Intelligence in Echocardiography for Anesthesiologists.
Chen X, Owen CA, Huang EC, Maggard BD, Latif RK, Clifford SP, Li J, Huang J. Chen X, et al. Among authors: owen ca. J Cardiothorac Vasc Anesth. 2021 Jan;35(1):251-261. doi: 10.1053/j.jvca.2020.08.048. Epub 2020 Aug 24. J Cardiothorac Vasc Anesth. 2021. PMID: 32962932 Review.
A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.
Wang X, Rojas-Quintero J, Zhang D, Nakajima T, Walker KH, Peh HY, Li Y, Fucci QA, Tesfaigzi Y, Owen CA. Wang X, et al. Among authors: owen ca. Mucosal Immunol. 2021 Mar;14(2):342-356. doi: 10.1038/s41385-020-0325-3. Epub 2020 Jul 20. Mucosal Immunol. 2021. PMID: 32690871 Free PMC article.
"T"eeing Up A Novel Therapy for Lymphangioleiomyomatosis.
Wang X, Rojas-Quintero J, Owen CA. Wang X, et al. Among authors: owen ca. Am J Respir Cell Mol Biol. 2020 Jun;62(6):678-680. doi: 10.1165/rcmb.2020-0049ED. Am J Respir Cell Mol Biol. 2020. PMID: 32101457 Free PMC article. No abstract available.
Plasma metabolomics and clinical predictors of survival differences in COPD patients.
Pinto-Plata V, Casanova C, Divo M, Tesfaigzi Y, Calhoun V, Sui J, Polverino F, Priolo C, Petersen H, de Torres JP, Marin JM, Owen CA, Baz R, Cordova E, Celli B. Pinto-Plata V, et al. Among authors: owen ca. Respir Res. 2019 Oct 15;20(1):219. doi: 10.1186/s12931-019-1167-y. Respir Res. 2019. PMID: 31615518 Free PMC article.
To Bet or Not to Bet on T-bet As a Therapeutic Target in Emphysema?
Wang X, Rojas-Quintero J, Owen CA. Wang X, et al. Among authors: owen ca. Am J Respir Cell Mol Biol. 2019 Oct;61(4):414-416. doi: 10.1165/rcmb.2019-0118ED. Am J Respir Cell Mol Biol. 2019. PMID: 30986358 Free PMC article. No abstract available.
Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection.
Rojas-Quintero J, Wang X, Tipper J, Burkett PR, Zuñiga J, Ashtekar AR, Polverino F, Rout A, Yambayev I, Hernández C, Jimenez L, Ramírez G, Harrod KS, Owen CA. Rojas-Quintero J, et al. Among authors: owen ca. JCI Insight. 2018 Dec 20;3(24):e99022. doi: 10.1172/jci.insight.99022. JCI Insight. 2018. PMID: 30568032 Free PMC article.
Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.
Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, Wright AL, Halonen M, Martinez FD, Kraft M, Guerra S, Ledford JG. Zhai J, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2019 Feb 1;199(3):302-312. doi: 10.1164/rccm.201807-1345OC. Am J Respir Crit Care Med. 2019. PMID: 30543455 Free PMC article.
Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease.
Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME. Pabón MA, et al. Among authors: owen ca. JCI Insight. 2018 Sep 20;3(18):e99592. doi: 10.1172/jci.insight.99592. eCollection 2018 Sep 20. JCI Insight. 2018. PMID: 30232271 Free PMC article.
A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD.
Wang X, Polverino F, Rojas-Quintero J, Zhang D, Sánchez J, Yambayev I, Lindqvist E, Virtala R, Djukanovic R, Davies DE, Wilson S, O'Donnell R, Cunoosamy D, Hazon P, Higham A, Singh D, Olsson H, Owen CA. Wang X, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2018 Jun 4;198(12):1500-18. doi: 10.1164/rccm.201711-2300OC. Online ahead of print. Am J Respir Crit Care Med. 2018. PMID: 29864380 Free PMC article.
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA. Polverino F, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1254-1267. doi: 10.1164/rccm.201707-1331OC. Am J Respir Crit Care Med. 2018. PMID: 29750543 Free PMC article.
Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD.
Nakajima T, Nakamura H, Owen CA, Yoshida S, Tsuduki K, Chubachi S, Shirahata T, Mashimo S, Nakamura M, Takahashi S, Minematsu N, Tateno H, Fujishima S, Asano K, Celli BR, Betsuyaku T. Nakajima T, et al. Among authors: owen ca. Dis Markers. 2016;2016:4093870. doi: 10.1155/2016/4093870. Epub 2016 Nov 22. Dis Markers. 2016. PMID: 27994288 Free PMC article.
B cells in chronic obstructive pulmonary disease: moving to center stage.
Polverino F, Seys LJ, Bracke KR, Owen CA. Polverino F, et al. Among authors: owen ca. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. doi: 10.1152/ajplung.00304.2016. Epub 2016 Aug 19. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27542809 Free PMC article. Review.
Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: a possible link between COPD and lung cancer?
Polverino F, Laucho-Contreras M, Rojas Quintero J, Divo M, Pinto-Plata V, Sholl L, de-Torres JP, Celli BR, Owen CA. Polverino F, et al. Among authors: owen ca. Multidiscip Respir Med. 2016 Apr 4;11:17. doi: 10.1186/s40248-016-0051-6. eCollection 2016. Multidiscip Respir Med. 2016. PMID: 27047662 Free PMC article.
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Cloonan SM, et al. Among authors: owen ca. Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11. Nat Med. 2016. PMID: 26752519 Free PMC article.
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.
Lange P, Celli B, Agustí A, Boje Jensen G, Divo M, Faner R, Guerra S, Marott JL, Martinez FD, Martinez-Camblor P, Meek P, Owen CA, Petersen H, Pinto-Plata V, Schnohr P, Sood A, Soriano JB, Tesfaigzi Y, Vestbo J. Lange P, et al. Among authors: owen ca. N Engl J Med. 2015 Jul 9;373(2):111-22. doi: 10.1056/NEJMoa1411532. N Engl J Med. 2015. PMID: 26154786 Free article.
B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.
Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Sholl L, Rosas IO, Agustí A, Celli BR, Owen CA. Polverino F, et al. Among authors: owen ca. Am J Respir Crit Care Med. 2015 Sep 15;192(6):695-705. doi: 10.1164/rccm.201501-0107OC. Am J Respir Crit Care Med. 2015. PMID: 26073875 Free PMC article.
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.
Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X. Lao T, et al. Among authors: owen ca. Genome Med. 2015 Feb 14;7(1):12. doi: 10.1186/s13073-015-0137-3. eCollection 2015. Genome Med. 2015. PMID: 25763110 Free PMC article.
Protective role for club cell secretory protein-16 (CC16) in the development of COPD.
Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, Divo M, Ashfaq N, Petersen H, Stripp B, Pilon AL, Tesfaigzi Y, Celli BR, Owen CA. Laucho-Contreras ME, et al. Among authors: owen ca. Eur Respir J. 2015 Jun;45(6):1544-56. doi: 10.1183/09031936.00134214. Epub 2015 Feb 19. Eur Respir J. 2015. PMID: 25700379 Free PMC article.
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
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