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Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice.

Nangia-Makker P, Ahrens M, Purandare N, Aras S, Li J, Gurdziel K, Jang H, Kim S, Shekhar MP. Nangia-Makker P, et al. Cells. 2025 Jun 18;14(12):923. doi: 10.3390/cells14120923. Cells. 2025. PMID: 40558548 Free PMC article.

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Comparative analysis of continuous similarity measures for compound identification in mass spectrometry-based metabolomics.

Dlugas H, Zhang X, Kim S. Dlugas H, et al. Chemometr Intell Lab Syst. 2025 Aug 15;263:105417. doi: 10.1016/j.chemolab.2025.105417. Epub 2025 May 3. Chemometr Intell Lab Syst. 2025. PMID: 40453508

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Social-Environmental Burden Is Associated with Increased Colorectal Cancer Mortality in Metropolitan Detroit.

Snider-Hoy NG, Buchalter RB, Hastert TA, Dyson G, Gronlund C, Ruterbusch JJ, Schwartz AG, Stoffel EM, Rozek LS, Purrington KS. Snider-Hoy NG, et al. Cancer Res Commun. 2025 Apr 1;5(4):694-705. doi: 10.1158/2767-9764.CRC-24-0503. Cancer Res Commun. 2025. PMID: 40293949 Free PMC article.

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Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growth.

Campeanu IJ, Jiang Y, Afisllari H, Dzinic S, Polin L, Yang ZQ. Campeanu IJ, et al. Cell Commun Signal. 2025 Apr 24;23(1):197. doi: 10.1186/s12964-025-02147-6. Cell Commun Signal. 2025. PMID: 40275371 Free PMC article.

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Synergies, partnership outcomes, and lessons learned: a qualitative evaluation of cancer center-coalition engagement.

Villalobos A, Lipman PD, Beebe-Dimmer J, Borrayo EA, Briant KJ, Bruegl A, Dee C, Chavez S, Drake B, Johnson SS, Kikuchi K, Leeman J, Lowery J, Mendoza JA, Parker M, Purvis L, Wells Sittig K, Thompson HS, Wangen M, Wheeler SB. Villalobos A, et al. JNCI Cancer Spectr. 2025 Apr 30;9(3):pkaf038. doi: 10.1093/jncics/pkaf038. JNCI Cancer Spectr. 2025. PMID: 40205614 Free PMC article.

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A Comparative Study of Network-Based Machine Learning Approaches for Binary Classification in Metabolomics.

Dlugas H, Kim S. Dlugas H, et al. Metabolites. 2025 Mar 3;15(3):174. doi: 10.3390/metabo15030174. Metabolites. 2025. PMID: 40137139 Free PMC article.

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A Comparison of Neighborhood Socioeconomic Deprivation Measures and the Association with Survival among Black and White Women with Endometrial Cancer.

Gottschlich A, Robinson JRM, Ruterbusch JJ, Burchett K, Adams RM, Washington A, Cote ML, Schwartz AG, Purrington KS, Wilson MR. Gottschlich A, et al. Cancer Epidemiol Biomarkers Prev. 2025 Jun 3;34(6):885-894. doi: 10.1158/1055-9965.EPI-24-1833. Cancer Epidemiol Biomarkers Prev. 2025. PMID: 40116712

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Three-Dimensional Models: Biomimetic Tools That Recapitulate Breast Tissue Architecture and Microenvironment to Study Ductal Carcinoma In Situ Transition to Invasive Ductal Breast Cancer.

Shah S, Osuala KO, Brock EJ, Ji K, Sloane BF, Mattingly RR. Shah S, et al. Cells. 2025 Feb 4;14(3):220. doi: 10.3390/cells14030220. Cells. 2025. PMID: 39937011 Free PMC article. Review.

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The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux.

Soukar I, Mitra A, Vo L, Rofoo M, Greenberg ML, Pile LA. Soukar I, et al. bioRxiv [Preprint]. 2025 Jan 15:2025.01.15.633193. doi: 10.1101/2025.01.15.633193. bioRxiv. 2025. PMID: 39868318 Free PMC article. Preprint.

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Association of Germline Pathogenic Variants in MUTYH and Other DNA Damage Response Genes With Lung Cancer Risk Among Non-Hispanic Whites and African Americans.

Trendowski MR, Lusk CM, Wenzlaff AS, Neslund-Dudas C, Purrington KS, Beebe-Dimmer JL, Schwartz AG. Trendowski MR, et al. JCO Precis Oncol. 2025 Jan;9:e2400558. doi: 10.1200/PO-24-00558. Epub 2025 Jan 24. JCO Precis Oncol. 2025. PMID: 39854657

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Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response.

Malysa A, Zhang XM, Bepler G. Malysa A, et al. Cells. 2024 Dec 26;14(1):12. doi: 10.3390/cells14010012. Cells. 2024. PMID: 39791713 Free PMC article. Review.

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Cancer-related health behaviors during the COVID 19 pandemic in geographically diverse samples across the US.

Greteman BB, Cole A, Charlton ME, Shannon J, Kepka D, Paskett ED, Borrayo EA, Studts JL, Thompson HS, Scarinci I, Hinton LC, Chrischilles EA, Garcia-Auguste CJ, Christini K, Aker H, Plascak JJ, Harper FWK, Baskin ML, Bae S, Pandya V, Kim YI, Faseru B, Befort C, Kuo H, Dignan M, Canedo J, Champion V, Drake BF, Davis KL, Friedman DL, Elsaid MI, Mama SK, Cohn WF. Greteman BB, et al. BMC Cancer. 2025 Jan 9;25(1):50. doi: 10.1186/s12885-024-13373-5. BMC Cancer. 2025. PMID: 39789488 Free PMC article.

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ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress.

Carter JL, Su Y, Al-Antary ET, Zhao J, Qiao X, Wang G, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Buck SA, Hüttemann M, Allen JE, Prabhu VV, Yang J, Taub JW, Ge Y. Carter JL, et al. J Exp Clin Cancer Res. 2025 Jan 9;44(1):10. doi: 10.1186/s13046-024-03267-6. J Exp Clin Cancer Res. 2025. PMID: 39780285 Free PMC article.

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Enhanced safety and efficacy profile of CD40 antibody upon encapsulation in pHe-triggered membrane-adhesive nanoliposomes.

Althobaiti S, Parajuli P, Luong D, Sau S, Polin LA, Kim S, Ge Y, Iyer AK, Gavande NS. Althobaiti S, et al. Nanomedicine (Lond). 2025 Jan;20(2):155-166. doi: 10.1080/17435889.2024.2446008. Epub 2024 Dec 29. Nanomedicine (Lond). 2025. PMID: 39764733

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Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity.

Chauhan H, Carruthers NJ, Stemmer PM, Schneider BL, Moszczynska A. Chauhan H, et al. Int J Mol Sci. 2024 Dec 5;25(23):13070. doi: 10.3390/ijms252313070. Int J Mol Sci. 2024. PMID: 39684782 Free PMC article.

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Decoding Functional and Developmental Trajectories of Tissue-Resident Uterine Dendritic Cells Through Integrative Omics.

Mor G, Singh A, Yang J, Adzibolosu N, Cai S, Kauf E, Yang L, Li Q, Li H, Werner A, Parthasarathy S, Ding J, Fortier J, Rodriguez-Garcia M, Diao LH. Mor G, et al. Res Sq [Preprint]. 2024 Nov 14:rs.3.rs-5424920. doi: 10.21203/rs.3.rs-5424920/v1. Res Sq. 2024. PMID: 39606471 Free PMC article. Preprint.

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Mechanistic Modeling of Spatial Heterogeneity of Drug Penetration and Exposure in the Human Central Nervous System and Brain Tumors.

Li J, Wickramasinghe C, Jiang J, Wu A, Jiang Y, Tovmasyan A, Kim S, Sanai N. Li J, et al. Clin Pharmacol Ther. 2025 Mar;117(3):690-703. doi: 10.1002/cpt.3505. Epub 2024 Nov 22. Clin Pharmacol Ther. 2025. PMID: 39575553

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An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer.

Bae TH, Sung KW, Pham TM, Najy AJ, Zamiri A, Jang H, Mun SR, Kim S, Kwon HK, Son YS, Shi D, Kregel S, Heath EI, Cher ML, Kwon YT, Kim HC. Bae TH, et al. Cancer Res. 2025 Jan 15;85(2):342-359. doi: 10.1158/0008-5472.CAN-24-0591. Cancer Res. 2025. PMID: 39531508 Free PMC article.

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A Novel One-Sample Mendelian Randomization Approach for Count-Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects.

Liyanage JSS, Hankins JS, Estepp JH, Srivastava D, Rashkin SR, Takemoto C, Li Y, Cui Y, Mori M, Weiss MJ, Kang G. Liyanage JSS, et al. Genet Epidemiol. 2025 Jan;49(1):e22602. doi: 10.1002/gepi.22602. Epub 2024 Nov 5. Genet Epidemiol. 2025. PMID: 39498871 Free PMC article.

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Autophagy and cancer therapy.

Pimentel JM, Zhou JY, Wu GS. Pimentel JM, et al. Cancer Lett. 2024 Nov 28;605:217285. doi: 10.1016/j.canlet.2024.217285. Epub 2024 Oct 10. Cancer Lett. 2024. PMID: 39395780 Review.

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Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironment.

Koksalar Alkan F, Caglayan AB, Alkan HK, Benson E, Gunduz YE, Sensoy O, Durdagi S, Zarbaliyev E, Dyson G, Assad H, Shull A, Chadli A, Shi H, Ozturk G, Korkaya H. Koksalar Alkan F, et al. Sci Rep. 2024 Sep 28;14(1):22487. doi: 10.1038/s41598-024-72989-6. Sci Rep. 2024. PMID: 39341857 Free PMC article.

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Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.

Debarba LK, Jayarathne HSM, Stilgenbauer L, Dos Santos ALT, Koshko L, Scofield S, Sullivan R, Mandal A, Klueh U, Sadagurski M. Debarba LK, et al. Diabetes. 2024 Dec 1;73(12):2065-2077. doi: 10.2337/db24-0110. Diabetes. 2024. PMID: 39320947 Free PMC article.

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Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T.

Brown MC, D'Anniballe VM, Boczkowski D, Kandadi H, Sheikh N, Kornahrens W Jr, Heath EI, Thakur A, Chen W, Lum L, Cackowski FC, Boerner J, Gunn MD, Armstrong AJ, Nair SK. Brown MC, et al. Cancer Res Commun. 2024 Oct 1;4(10):2724-2733. doi: 10.1158/2767-9764.CRC-24-0439. Cancer Res Commun. 2024. PMID: 39320053 Free PMC article.

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Phase II trial of multi-kinase inhibitor ESK981 in patients with metastatic castration-resistant prostate cancer.

Heath EI, Chen W, Heilbrun L, Choi JE, Dobson K, Smith M, Maj T, Vaishampayan U, Kryczek I, Zou W, Chinnaiyan AM, Qiao Y. Heath EI, et al. Invest New Drugs. 2024 Oct;42(5):566-574. doi: 10.1007/s10637-024-01463-x. Epub 2024 Sep 3. Invest New Drugs. 2024. PMID: 39227508 Free PMC article. Clinical Trial.

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Peripheral-derived regulatory T cells contribute to tumor-mediated immune suppression in a nonredundant manner.

Hossain MM, King P, Hackett J, Gerard HC, Niwinski R, Wu L, Van Kaer L, Dyson G, Gibson H, Borowsky AD, Sebzda E. Hossain MM, et al. Proc Natl Acad Sci U S A. 2024 Sep 3;121(36):e2404916121. doi: 10.1073/pnas.2404916121. Epub 2024 Aug 29. Proc Natl Acad Sci U S A. 2024. PMID: 39207730 Free PMC article.

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Hydroquinone impairs trophoblast migration and invasion via AHR-twist-IFITM1 axis.

Maxwell A, Swanson G, Thy Nguyen A, Hu A, Richards D, You Y, Stephan L, Manaloto M, Liao A, Ding J, Mor G. Maxwell A, et al. Placenta. 2024 Sep 26;155:88-99. doi: 10.1016/j.placenta.2024.07.315. Epub 2024 Aug 10. Placenta. 2024. PMID: 39173312

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Health Disparities among Patients with Cancer Who Received Molecular Testing for Biomarker-Directed Therapy.

Heath E, Dyson G, Ribeiro JR, Xiu J, Poorman K, Mamdani H, Al-Hallak MN, Shields AF, Elayoubi JA, Winer IS, Cackowski FC, Puckrein GA, Lopes GL, Jones N, Hauke RJ, Kareff SA, Radovich M, Sledge GW, Spetzler DB, Vidal GA, Marshall JL. Heath E, et al. Cancer Res Commun. 2024 Oct 1;4(10):2598-2609. doi: 10.1158/2767-9764.CRC-24-0321. Cancer Res Commun. 2024. PMID: 39172022 Free PMC article.

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The long-chain polyfluorinated alkyl substance perfluorohexane sulfonate (PFHxS) promotes bone marrow adipogenesis.

Garmo LC, Herroon MK, Mecca S, Wilson A, Allen DR, Agarwal M, Kim S, Petriello MC, Podgorski I. Garmo LC, et al. Toxicol Appl Pharmacol. 2024 Oct;491:117047. doi: 10.1016/j.taap.2024.117047. Epub 2024 Aug 5. Toxicol Appl Pharmacol. 2024. PMID: 39111555 Free PMC article.

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Adipose microenvironment promotes hypersialylation of ovarian cancer cells.

Fox A, Leonard GD, Adzibolosu N, Wong T, Tedja R, Sharma S, Gogoi R, Morris R, Mor G, Fehl C, Alvero AB. Fox A, et al. Front Oncol. 2024 Jul 22;14:1432333. doi: 10.3389/fonc.2024.1432333. eCollection 2024. Front Oncol. 2024. PMID: 39104719 Free PMC article.

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Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis.

Bhatia P, Mehmood S, Doyon-Reale N, Rosati R, Stemmer PM, Jamesdaniel S. Bhatia P, et al. Front Cell Neurosci. 2024 Jul 22;18:1408208. doi: 10.3389/fncel.2024.1408208. eCollection 2024. Front Cell Neurosci. 2024. PMID: 39104440 Free PMC article.

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Neurotoxic Methamphetamine Doses Alter CDCel-1 Levels and Its Interaction with Vesicular Monoamine Transporter-2 in Rat Striatum.

Chauhan H, Carruthers N, Stemmer P, Schneider BP, Moszczynska A. Chauhan H, et al. bioRxiv [Preprint]. 2024 Jul 23:2024.07.21.604458. doi: 10.1101/2024.07.21.604458. bioRxiv. 2024. PMID: 39091864 Free PMC article. Preprint.

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A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy.

Bisen S, Verma SK, Mukhopadhyay CS, Singh NK. Bisen S, et al. Exp Mol Med. 2024 Aug;56(8):1703-1716. doi: 10.1038/s12276-024-01279-y. Epub 2024 Aug 1. Exp Mol Med. 2024. PMID: 39085349 Free PMC article.

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Genome-wide analysis of TFIIB's role in termination of transcription.

O'Brien MJ, Schrader J, Ansari A. O'Brien MJ, et al. Res Sq [Preprint]. 2024 Jul 15:rs.3.rs-4619136. doi: 10.21203/rs.3.rs-4619136/v1. Res Sq. 2024. PMID: 39070618 Free PMC article. Preprint.

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Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates.

O'Connor C, Schneider M, Katinas JM, Nayeen MJ, Shah K, Magdum T, Sharma A, Kim S, Bao X, Li J, Dann CE, Gangjee A, Matherly LH, Hou Z. O'Connor C, et al. Mol Pharmacol. 2024 Sep 17;106(4):173-187. doi: 10.1124/molpharm.124.000912. Mol Pharmacol. 2024. PMID: 39048308

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Kinase-catalyzed biotinylation for discovery and validation of substrates to multispecificity kinases NME1 and NME2.

Gary CR, Acharige NPN, Oyewumi TO, Pflum MKH. Gary CR, et al. J Biol Chem. 2024 Aug;300(8):107588. doi: 10.1016/j.jbc.2024.107588. Epub 2024 Jul 18. J Biol Chem. 2024. PMID: 39032654 Free PMC article.

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Evaluation of the Immune Response within the Tumor Microenvironment in African American and Non-Hispanic White Patients with Non-Small Cell Lung Cancer.

Trendowski MR, Watza D, Lusk CM, Lonardo F, Ratliff V, Wenzlaff AS, Mamdani H, Neslund-Dudas C, Boerner JL, Schwartz AG, Gibson HM. Trendowski MR, et al. Cancer Epidemiol Biomarkers Prev. 2024 Sep 3;33(9):1220-1228. doi: 10.1158/1055-9965.EPI-24-0333. Cancer Epidemiol Biomarkers Prev. 2024. PMID: 38953893 Free PMC article.

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TGFβ in Pancreas and Colorectal Cancer: Opportunities to Overcome Therapeutic Resistance.

Johansen AM, Forsythe SD, McGrath CT, Barker G, Jimenez H, Paluri RK, Pasche BC. Johansen AM, et al. Clin Cancer Res. 2024 Sep 3;30(17):3676-3687. doi: 10.1158/1078-0432.CCR-24-0468. Clin Cancer Res. 2024. PMID: 38916900 Free PMC article. Review.

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Race-Related Differences in Sipuleucel-T Response among Men with Metastatic Castrate-Resistant Prostate Cancer.

Heath EI, Thakur A, Chen W, Hwang C, Paller CJ, Cackowski FC, Boerner JL, Heilbrun L, Smith MP, Schalk DL, Schienschang A, Whitaker SA, Polend A, Smith D, Vaishampayan UN, Dickow B, Lum LG. Heath EI, et al. Cancer Res Commun. 2024 Jul 1;4(7):1715-1725. doi: 10.1158/2767-9764.CRC-24-0112. Cancer Res Commun. 2024. PMID: 38856749 Free PMC article.

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Racial and socioeconomic disparities in survival among patients with metastatic non-small cell lung cancer.

Uprety D, Seaton R, Hadid T, Mamdani H, Sukari A, Ruterbusch JJ, Schwartz AG. Uprety D, et al. J Natl Cancer Inst. 2024 Oct 1;116(10):1697-1704. doi: 10.1093/jnci/djae118. J Natl Cancer Inst. 2024. PMID: 38830035 Free PMC article.

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Multiplicity of benign breast disease lesions and breast cancer risk in African American women.

Patil V, Ruterbusch JJ, Chen W, Boerner JL, Abdulfatah E, Alosh B, Pardeshi V, Shaik AN, Bandyopadhyay S, Ali-Fehmi R, Cote ML. Patil V, et al. Front Oncol. 2024 May 16;14:1410819. doi: 10.3389/fonc.2024.1410819. eCollection 2024. Front Oncol. 2024. PMID: 38817898 Free PMC article.

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Hypothalamic sex-specific metabolic shift by canagliflozin during aging.

Jayarathne HSM, Sullivan R, Stilgenbauer L, Debarba LK, Kuchumov A, Koshko L, Scofield S, Liu W, Ginsburg BC, Miller RA, Sadagurski M. Jayarathne HSM, et al. Geroscience. 2024 Oct;46(5):4479-4493. doi: 10.1007/s11357-024-01214-z. Epub 2024 May 27. Geroscience. 2024. PMID: 38801647 Free PMC article.

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The Janus kinase 1 is critical for pancreatic cancer initiation and progression.

Shrestha H, Rädler PD, Dennaoui R, Wicker MN, Rajbhandari N, Sun Y, Peck AR, Vistisen K, Triplett AA, Beydoun R, Sterneck E, Saur D, Rui H, Wagner KU. Shrestha H, et al. Cell Rep. 2024 May 28;43(5):114202. doi: 10.1016/j.celrep.2024.114202. Epub 2024 May 10. Cell Rep. 2024. PMID: 38733583 Free PMC article.

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Mild Hyperthermia Enhanced Liposomal Doxorubicin Delivery and CD8⁺ T cell Infiltration in Triple Negative Breast Cancer.

Rezazadeh F, Saadat W, Smith R, Pattyn A, Malik M, Yazdani F, Saliganan AD, Mehrmohammadi M, Viola NT. Rezazadeh F, et al. bioRxiv [Preprint]. 2024 Apr 27:2024.04.25.591226. doi: 10.1101/2024.04.25.591226. bioRxiv. 2024. PMID: 38712049 Free PMC article. Preprint.

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Quantitative profiling of cochlear synaptosomal proteins in cisplatin-induced synaptic dysfunction.

Shahab M, Rosati R, Stemmer PM, Dombkowski A, Jamesdaniel S. Shahab M, et al. Hear Res. 2024 Jun;447:109022. doi: 10.1016/j.heares.2024.109022. Epub 2024 Apr 27. Hear Res. 2024. PMID: 38705005 Free PMC article.

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The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes.

St Louis BM, Quagliato SM, Su Y-T, Dyson G, Lee P-C. St Louis BM, et al. mBio. 2024 May 8;15(5):e0342923. doi: 10.1128/mbio.03429-23. Epub 2024 Apr 16. mBio. 2024. PMID: 38624208 Free PMC article.

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The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes.

Gupta N, Somayajulu M, Gurdziel K, LoGrasso G, Aziz H, Rosati R, McClellan S, Pitchaikannu A, Santra M, Shukkur MFA, Stemmer P, Hazlett LD, Xu S. Gupta N, et al. Sci Rep. 2024 Apr 1;14(1):7676. doi: 10.1038/s41598-024-58403-1. Sci Rep. 2024. PMID: 38561433 Free PMC article.

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Protein kinase A is a functional component of focal adhesions.

Kang M, Senatore AJ, Naughton H, McTigue M, Beltman RJ, Herppich AA, Pflum MKH, Howe AK. Kang M, et al. J Biol Chem. 2024 May;300(5):107234. doi: 10.1016/j.jbc.2024.107234. Epub 2024 Mar 27. J Biol Chem. 2024. PMID: 38552737 Free PMC article.

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Comparative evaluation of trypsin and elastase digestion techniques for isolation of murine retinal vasculature.

Sharma A, Gupta DK, Bisen S, Singh NK. Sharma A, et al. Microvasc Res. 2024 Jul;154:104682. doi: 10.1016/j.mvr.2024.104682. Epub 2024 Mar 21. Microvasc Res. 2024. PMID: 38521153 Free PMC article.

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Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3×anti-GD2 bispecific antibody armed T cells.

Yankelevich M, Thakur A, Modak S, Chu R, Taub J, Martin A, Schalk D, Schienshang A, Whitaker S, Rea K, Lee DW, Liu Q, Shields AF, Cheung NV, Lum LG. Yankelevich M, et al. J Immunother Cancer. 2024 Mar 21;12(3):e008744. doi: 10.1136/jitc-2023-008744. J Immunother Cancer. 2024. PMID: 38519053 Free PMC article. Clinical Trial.

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Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironment.

Korkaya H, Koksalar Alkan F, Caglayan A, Alkan H, Benson E, Gunduz Y, Sensoy O, Durdagi S, Zarbaliyev E, Dyson G, Assad H, Shull A, Chadli A, Shi H, Ozturk G. Korkaya H, et al. Res Sq [Preprint]. 2024 Feb 22:rs.3.rs-3959342. doi: 10.21203/rs.3.rs-3959342/v1. Res Sq. 2024. Update in: Sci Rep. 2024 Sep 28;14(1):22487. doi: 10.1038/s41598-024-72989-6. PMID: 38464167 Free PMC article. Updated. Preprint.

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Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer.

Wallace-Povirk A, O'Connor C, Dekhne AS, Bao X, Nayeen MJ, Schneider M, Katinas JM, Wong-Roushar J, Kim S, Polin L, Li J, Back JB, Dann CE 3rd, Gangjee A, Hou Z, Matherly LH. Wallace-Povirk A, et al. Mol Cancer Ther. 2024 Jun 4;23(6):809-822. doi: 10.1158/1535-7163.MCT-23-0550. Mol Cancer Ther. 2024. PMID: 38377173 Free PMC article.

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Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity.

Agarwal M, Roth K, Yang Z, Sharma R, Maddipati K, Westrick J, Petriello MC. Agarwal M, et al. Environ Res. 2024 Jun 1;250:118492. doi: 10.1016/j.envres.2024.118492. Epub 2024 Feb 17. Environ Res. 2024. PMID: 38373550 Free PMC article.

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SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.

Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J. Chen G, et al. Commun Biol. 2024 Feb 12;7(1):173. doi: 10.1038/s42003-024-05861-y. Commun Biol. 2024. PMID: 38347107 Free PMC article.

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An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum.

Wong T, Tedja R, Chehade H, Morris R, Alvero AB, Mor G. Wong T, et al. J Vis Exp. 2024 Jan 26;(203). doi: 10.3791/66031. J Vis Exp. 2024. PMID: 38345216

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Hyperglycemic Stress Induces Expression, Degradation, and Nuclear Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIβ) in Pancreatic β-Cells.

Gleason N, Kowluru A. Gleason N, et al. Cells. 2024 Feb 1;13(3):272. doi: 10.3390/cells13030272. Cells. 2024. PMID: 38334664 Free PMC article.

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Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System.

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Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers.

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Targeting GD2-positive Refractory/Resistant Neuroblastoma and Osteosarcoma with Anti- CD3 x Anti-GD2 Bispecific Antibody Armed T cells.

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The role of the immune response and inflammatory pathways in TNF-related apoptosis-inducing ligand (TRAIL) resistance in triple-negative breast cancer cells.

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Naturally occurring autoimmune disease in (NZB X NZW) F1 mice is correlated with suppression of MZ B cell development due to aberrant B Cell Receptor (BCR) signaling, which is exacerbated by exposure to inorganic mercury.

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Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle.

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Identification of PP1c-PPP1R12A Substrates Using Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates.

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Housing instability and psychological distress in African American cancer survivors: findings from the Detroit Research on Cancer Survivors study.

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Defective monocyte plasticity and altered cAMP pathway characterize USB1-mutated poikiloderma with neutropenia Clericuzio type.

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Improved Rate of Negative Margins for Inflammatory Breast Cancer Using Intraoperative Frozen Section Analysis.

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Mast Cell Deficiency in Mice Attenuates Insulin Phenolic Preservative-Induced Inflammation.

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The Intersection of Metabolomics and Data Science.

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Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms.

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Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations.

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The impact of preexisting comorbidities on receipt of cancer therapy among women with Stage I-III breast cancer in the Detroit Research on Cancer Survivors cohort.

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Methods for making and observing model lipid droplets.

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Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR signaling.

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Prevalence of Lung Cancer Screening Among Eligible Adults in 4 US States in 2021.

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Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer.

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The Role of Surgery in Stage I Small Cell Lung Cancer: A National VA Database Analysis.

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¹⁸ F-sodium fluoride positron emission tomography quantitation of bone metastases in African American and non-African American men with metastatic prostate cancer.

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Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.

Tong N, Wong-Roushar J, Wallace-Povirk A, Shah Y, Nyman MC, Katinas JM, Schneider M, O'Connor C, Bao X, Kim S, Li J, Hou Z, Matherly LH, Dann CE 3rd, Gangjee A. Tong N, et al. ACS Pharmacol Transl Sci. 2023 Apr 26;6(5):748-770. doi: 10.1021/acsptsci.3c00020. eCollection 2023 May 12. ACS Pharmacol Transl Sci. 2023. PMID: 37200803 Free PMC article.

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The role of area-level socioeconomic disadvantage in racial disparities in cancer incidence in metropolitan Detroit.

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Selective ablation of TRA-1-60⁺ pluripotent stem cells suppresses tumor growth of prostate cancer.

White JM, Ramos N, Saliganan AD, Chung JY, Bell M, Lindquist J, Conner K, Wiesend WN, Schopperle M, Patrick SM, Kim S, Heath EI, Escorcia FE, Viola NT. White JM, et al. Theranostics. 2023 Mar 27;13(7):2057-2071. doi: 10.7150/thno.78915. eCollection 2023. Theranostics. 2023. PMID: 37153742 Free PMC article.

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Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure.

Maxwell A, Adzibolosu N, Hu A, You Y, Stemmer PM, Ruden DM, Petriello MC, Sadagurski M, Debarba LK, Koshko L, Ramadoss J, Nguyen AT, Richards D, Liao A, Mor G, Ding J. Maxwell A, et al. iScience. 2023 Feb 27;26(4):106287. doi: 10.1016/j.isci.2023.106287. eCollection 2023 Apr 21. iScience. 2023. PMID: 37153445 Free PMC article.

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Quality of life in endometrial cancer survivors by grade of disease.

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Automated radiosynthesis of 1-(2-[¹⁸ F]fluoroethyl)-L-tryptophan ([¹⁸ F]FETrp) for positron emission tomography (PET) imaging of cancer in humans.

Jiang H, Guo Y, Cai H, Viola N, Shields AF, Muzik O, Juhasz C. Jiang H, et al. J Labelled Comp Radiopharm. 2023 Jun;66(7-8):180-188. doi: 10.1002/jlcr.4027. Epub 2023 May 11. J Labelled Comp Radiopharm. 2023. PMID: 37118900 Free PMC article.

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Disrupted intercellular bridges and spermatogenesis in fatty acyl-CoA reductase 1 knockout mice: A new model of ether lipid deficiency.

Pan B, Yuan S, Mayernik L, Yap YT, Moin K, Chung CS, Maddipati K, Krawetz SA, Zhang Z, Hess RA, Chen X. Pan B, et al. FASEB J. 2023 May;37(5):e22908. doi: 10.1096/fj.202201848R. FASEB J. 2023. PMID: 37039784 Free PMC article.

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Belzutifan plus cabozantinib for patients with advanced clear cell renal cell carcinoma previously treated with immunotherapy: an open-label, single-arm, phase 2 study.

Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS. Choueiri TK, et al. Lancet Oncol. 2023 May;24(5):553-562. doi: 10.1016/S1470-2045(23)00097-9. Epub 2023 Mar 31. Lancet Oncol. 2023. PMID: 37011650 Clinical Trial.

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Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model.

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