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IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.
Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, Livraghi-Butrico A, Kesimer M, Ribeiro CM, O'Neal WK, Boucher RC. Chen G, et al. Among authors: randell sh. J Clin Invest. 2019 Oct 1;129(10):4433-4450. doi: 10.1172/JCI125669. J Clin Invest. 2019. PMID: 31524632 Free PMC article.
Cytokine secretion by cystic fibrosis airway epithelial cells.
Becker MN, Sauer MS, Muhlebach MS, Hirsh AJ, Wu Q, Verghese MW, Randell SH. Becker MN, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2004 Mar 1;169(5):645-53. doi: 10.1164/rccm.200207-765OC. Epub 2003 Dec 11. Am J Respir Crit Care Med. 2004. PMID: 14670800
C-Mannosylation of MUC5AC and MUC5B Cys subdomains.
Perez-Vilar J, Randell SH, Boucher RC. Perez-Vilar J, et al. Among authors: randell sh. Glycobiology. 2004 Apr;14(4):325-37. doi: 10.1093/glycob/cwh041. Epub 2004 Jan 12. Glycobiology. 2004. PMID: 14718370
Effective mucus clearance is essential for respiratory health.
Randell SH, Boucher RC; University of North Carolina Virtual Lung Group. Randell SH, et al. Am J Respir Cell Mol Biol. 2006 Jul;35(1):20-8. doi: 10.1165/rcmb.2006-0082SF. Epub 2006 Mar 9. Am J Respir Cell Mol Biol. 2006. PMID: 16528010 Free PMC article. Review. No abstract available.
Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment.
Livraghi A, Grubb BR, Hudson EJ, Wilkinson KJ, Sheehan JK, Mall MA, O'Neal WK, Boucher RC, Randell SH. Livraghi A, et al. Among authors: randell sh. J Immunol. 2009 Apr 1;182(7):4357-67. doi: 10.4049/jimmunol.0802557. J Immunol. 2009. PMID: 19299736 Free PMC article.
VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells.
Jones LC, Moussa L, Fulcher ML, Zhu Y, Hudson EJ, O'Neal WK, Randell SH, Lazarowski ER, Boucher RC, Kreda SM. Jones LC, et al. Among authors: randell sh. J Physiol. 2012 Feb 1;590(3):545-62. doi: 10.1113/jphysiol.2011.222091. Epub 2011 Dec 5. J Physiol. 2012. PMID: 22144578 Free PMC article.
Regional differences in rat conjunctival ion transport activities.
Yu D, Thelin WR, Rogers TD, Stutts MJ, Randell SH, Grubb BR, Boucher RC. Yu D, et al. Among authors: randell sh. Am J Physiol Cell Physiol. 2012 Oct 1;303(7):C767-80. doi: 10.1152/ajpcell.00195.2012. Epub 2012 Jul 18. Am J Physiol Cell Physiol. 2012. PMID: 22814399 Free PMC article.
Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.
Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR. Livraghi-Butrico A, et al. Among authors: randell sh. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L469-80. doi: 10.1152/ajplung.00150.2012. Epub 2013 Feb 1. Am J Physiol Lung Cell Mol Physiol. 2013. PMID: 23377346 Free PMC article.
Characterization of Rat Meibomian Gland Ion and Fluid Transport.
Yu D, Davis RM, Aita M, Burns KA, Clapp PW, Gilmore RC, Chua M, O'Neal WK, Schlegel R, Randell SH, C Boucher R. Yu D, et al. Among authors: randell sh. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2328-43. doi: 10.1167/iovs.15-17945. Invest Ophthalmol Vis Sci. 2016. PMID: 27127933 Free PMC article.
Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.
Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R. Terryah ST, et al. Among authors: randell sh. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L192-L205. doi: 10.1152/ajplung.00546.2016. Epub 2017 Oct 5. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 28982737 Free PMC article.
Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome.
Ghosh A, Coakley RC, Mascenik T, Rowell TR, Davis ES, Rogers K, Webster MJ, Dang H, Herring LE, Sassano MF, Livraghi-Butrico A, Van Buren SK, Graves LM, Herman MA, Randell SH, Alexis NE, Tarran R. Ghosh A, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC. Am J Respir Crit Care Med. 2018. PMID: 29481290 Free PMC article.
Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.
Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, Nagase T, O'Neal WK, Boucher RC. Okuda K, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC. Am J Respir Crit Care Med. 2019. PMID: 30352166 Free PMC article.
XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.
Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O'Neal WK, Boucher RC. Chen G, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2019 Jul 15;200(2):220-234. doi: 10.1164/rccm.201810-1972OC. Am J Respir Crit Care Med. 2019. PMID: 30973754 Free PMC article.
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH 3rd, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, Gralinski LE, Schäfer A, Dang H, Gilmore R, Nakano S, Sun L, Fulcher ML, Livraghi-Butrico A, Nicely NI, Cameron M, Cameron C, Kelvin DJ, de Silva A, Margolis DM, Markmann A, Bartelt L, Zumwalt R, Martinez FJ, Salvatore SP, Borczuk A, Tata PR, Sontake V, Kimple A, Jaspers I, O'Neal WK, Randell SH, Boucher RC, Baric RS. Hou YJ, et al. Among authors: randell sh. Cell. 2020 Jul 23;182(2):429-446.e14. doi: 10.1016/j.cell.2020.05.042. Epub 2020 May 27. Cell. 2020. PMID: 32526206 Free PMC article.
Fibrocyte accumulation in the lungs of cystic fibrosis patients.
Kasam RK, Gajjala PR, Jegga AG, Courtney JA, Randell SH, Kramer EL, Clancy JP, Madala SK. Kasam RK, et al. Among authors: randell sh. J Cyst Fibros. 2020 Sep;19(5):815-822. doi: 10.1016/j.jcf.2020.06.011. Epub 2020 Jun 25. J Cyst Fibros. 2020. PMID: 32593509 Free PMC article.
Human Fallopian Tube Epithelial Cell Culture Model To Study Host Responses to Chlamydia trachomatis Infection.
McQueen BE, Kiatthanapaiboon A, Fulcher ML, Lam M, Patton K, Powell E, Kollipara A, Madden V, Suchland RJ, Wyrick P, O'Connell CM, Reidel B, Kesimer M, Randell SH, Darville T, Nagarajan UM. McQueen BE, et al. Among authors: randell sh. Infect Immun. 2020 Aug 19;88(9):e00105-20. doi: 10.1128/IAI.00105-20. Print 2020 Aug 19. Infect Immun. 2020. PMID: 32601108 Free PMC article.
SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo.
Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Edwards CE, Tse LV, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. Hou YJ, et al. Among authors: randell sh. bioRxiv [Preprint]. 2020 Sep 29:2020.09.28.317685. doi: 10.1101/2020.09.28.317685. bioRxiv. 2020. PMID: 33024969 Free PMC article. Updated. Preprint.
Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.
Katsura H, Sontake V, Tata A, Kobayashi Y, Edwards CE, Heaton BE, Konkimalla A, Asakura T, Mikami Y, Fritch EJ, Lee PJ, Heaton NS, Boucher RC, Randell SH, Baric RS, Tata PR. Katsura H, et al. Among authors: randell sh. Cell Stem Cell. 2020 Dec 3;27(6):890-904.e8. doi: 10.1016/j.stem.2020.10.005. Epub 2020 Oct 21. Cell Stem Cell. 2020. PMID: 33128895 Free PMC article.
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.
Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Graham R, Edwards CE, Tse LV, Okuda K, Markmann AJ, Bartelt L, de Silva A, Margolis DM, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. Hou YJ, et al. Among authors: randell sh. Science. 2020 Dec 18;370(6523):1464-1468. doi: 10.1126/science.abe8499. Epub 2020 Nov 12. Science. 2020. PMID: 33184236 Free PMC article.
Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.
Okuda K, Dang H, Kobayashi Y, Carraro G, Nakano S, Chen G, Kato T, Asakura T, Gilmore RC, Morton LC, Lee RE, Mascenik T, Yin WN, Barbosa Cardenas SM, O'Neal YK, Minnick CE, Chua M, Quinney NL, Gentzsch M, Anderson CW, Ghio A, Matsui H, Nagase T, Ostrowski LE, Grubb BR, Olsen JC, Randell SH, Stripp BR, Tata PR, O'Neal WK, Boucher RC. Okuda K, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2021 May 15;203(10):1275-1289. doi: 10.1164/rccm.202008-3198OC. Am J Respir Crit Care Med. 2021. PMID: 33321047 Free PMC article.
Reuse of Cell Culture Inserts for In Vitro Human Primary Airway Epithelial Cell Studies.
Kato T, Mikami Y, Sun L, Rogers TD, Grubb BR, Morrison CB, Ehre C, Sears PR, Ostrowski LE, Randell SH, Boucher RC. Kato T, et al. Among authors: randell sh. Am J Respir Cell Mol Biol. 2021 Jun;64(6):760-764. doi: 10.1165/rcmb.2021-0033LE. Am J Respir Cell Mol Biol. 2021. PMID: 33788673 Free PMC article. No abstract available.
The Big Impact of Small Airway pH.
Okuda K, Randell SH, Birket SE. Okuda K, et al. Among authors: randell sh. Am J Respir Cell Mol Biol. 2021 Aug;65(2):123-125. doi: 10.1165/rcmb.2021-0070ED. Am J Respir Cell Mol Biol. 2021. PMID: 33831321 Free PMC article. No abstract available.
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. Carraro G, et al. Among authors: randell sh. Nat Med. 2021 May;27(5):806-814. doi: 10.1038/s41591-021-01332-7. Epub 2021 May 6. Nat Med. 2021. PMID: 33958799 Free PMC article.
Epigenome editing of the CFTR-locus for treatment of cystic fibrosis.
Kabadi AM, Machlin L, Dalal N, Lee RE, McDowell I, Shah NN, Drowley L, Randell SH, Reddy TE. Kabadi AM, et al. Among authors: randell sh. J Cyst Fibros. 2022 Jan;21(1):164-171. doi: 10.1016/j.jcf.2021.04.008. Epub 2021 May 25. J Cyst Fibros. 2022. PMID: 34049825 Free PMC article.
Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial.
Esther CR Jr, Kimura KS, Mikami Y, Edwards CE, Das SR, Freeman MH, Strickland BA, Brown HM, Wessinger BC, Gupta VC, Von Wahlde K, Sheng Q, Huang LC, Bacon DR, Kimple AJ, Ceppe AS, Kato T, Pickles RJ, Randell SH, Baric RS, Turner JH, Boucher RC. Esther CR Jr, et al. Among authors: randell sh. Int Forum Allergy Rhinol. 2022 Sep;12(9):1137-1147. doi: 10.1002/alr.22975. Epub 2022 Jan 31. Int Forum Allergy Rhinol. 2022. PMID: 35040594 Free PMC article. Clinical Trial.
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.
Kadur Lakshminarasimha Murthy P, Sontake V, Tata A, Kobayashi Y, Macadlo L, Okuda K, Conchola AS, Nakano S, Gregory S, Miller LA, Spence JR, Engelhardt JF, Boucher RC, Rock JR, Randell SH, Tata PR. Kadur Lakshminarasimha Murthy P, et al. Among authors: randell sh. Nature. 2022 Apr;604(7904):111-119. doi: 10.1038/s41586-022-04541-3. Epub 2022 Mar 30. Nature. 2022. PMID: 35355018 Free PMC article.
Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.
Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, Goodell HP, Thacker H, Loznev HT, Forsberg LJ, Nagase T, Rubinstein M, Randell SH, Tiemeyer M, Hill DB, Kesimer M, O'Neal WK, Ballard ST, Freeman R, Button B, Boucher RC. Kato T, et al. Among authors: randell sh. Sci Adv. 2022 Apr;8(13):eabm9718. doi: 10.1126/sciadv.abm9718. Epub 2022 Apr 1. Sci Adv. 2022. PMID: 35363522 Free PMC article.
Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease.
Kato T, Asakura T, Edwards CE, Dang H, Mikami Y, Okuda K, Chen G, Sun L, Gilmore RC, Hawkins P, De la Cruz G, Cooley MR, Bailey AB, Hewitt SM, Chertow DS, Borczuk AC, Salvatore S, Martinez FJ, Thorne LB, Askin FB, Ehre C, Randell SH, O'Neal WK, Baric RS, Boucher RC. Kato T, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC. Am J Respir Crit Care Med. 2022. PMID: 35816430 Free PMC article.
Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough.
Lee RE, Lewis CA, He L, Bulik-Sullivan EC, Gallant SC, Mascenik TM, Dang H, Cholon DM, Gentzsch M, Morton LC, Minges JT, Theile JW, Castle NA, Knowles MR, Kimple AJ, Randell SH. Lee RE, et al. Among authors: randell sh. J Clin Invest. 2022 Sep 15;132(18):e154571. doi: 10.1172/JCI154571. J Clin Invest. 2022. PMID: 35900863 Free PMC article.
A multimodal iPSC platform for cystic fibrosis drug testing.
Berical A, Lee RE, Lu J, Beermann ML, Le Suer JA, Mithal A, Thomas D, Ranallo N, Peasley M, Stuffer A, Bukis K, Seymour R, Harrington J, Coote K, Valley H, Hurley K, McNally P, Mostoslavsky G, Mahoney J, Randell SH, Hawkins FJ. Berical A, et al. Among authors: randell sh. Nat Commun. 2022 Jul 29;13(1):4270. doi: 10.1038/s41467-022-31854-8. Nat Commun. 2022. PMID: 35906215 Free PMC article.
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2.
Barnett KC, Xie Y, Asakura T, Song D, Liang K, Taft-Benz SA, Guo H, Yang S, Okuda K, Gilmore RC, Loome JF, Oguin Iii TH, Sempowski GD, Randell SH, Heise MT, Lei YL, Boucher RC, Ting JP. Barnett KC, et al. Among authors: randell sh. Cell Host Microbe. 2023 Feb 8;31(2):243-259.e6. doi: 10.1016/j.chom.2022.12.005. Epub 2022 Dec 9. Cell Host Microbe. 2023. PMID: 36563691 Free PMC article.
Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.
Mikami Y, Grubb BR, Rogers TD, Dang H, Asakura T, Kota P, Gilmore RC, Okuda K, Morton LC, Sun L, Chen G, Wykoff JA, Ehre C, Vilar J, van Heusden C, Livraghi-Butrico A, Gentzsch M, Button B, Stutts MJ, Randell SH, O'Neal WK, Boucher RC. Mikami Y, et al. Among authors: randell sh. Sci Transl Med. 2023 Jun 7;15(699):eabo7728. doi: 10.1126/scitranslmed.abo7728. Epub 2023 Jun 7. Sci Transl Med. 2023. PMID: 37285404
Novel human bronchial epithelial cell lines for cystic fibrosis research.
Fulcher ML, Gabriel SE, Olsen JC, Tatreau JR, Gentzsch M, Livanos E, Saavedra MT, Salmon P, Randell SH. Fulcher ML, et al. Among authors: randell sh. Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L82-91. doi: 10.1152/ajplung.90314.2008. Epub 2008 Oct 31. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 18978040 Free PMC article.
Type 2 alveolar cells are stem cells in adult lung.
Barkauskas CE, Cronce MJ, Rackley CR, Bowie EJ, Keene DR, Stripp BR, Randell SH, Noble PW, Hogan BL. Barkauskas CE, et al. Among authors: randell sh. J Clin Invest. 2013 Jul;123(7):3025-36. doi: 10.1172/JCI68782. Epub 2013 Jun 10. J Clin Invest. 2013. PMID: 23921127 Free PMC article.
Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.
Fritzsching B, Zhou-Suckow Z, Trojanek JB, Schubert SC, Schatterny J, Hirtz S, Agrawal R, Muley T, Kahn N, Sticht C, Gunkel N, Welte T, Randell SH, Länger F, Schnabel P, Herth FJ, Mall MA. Fritzsching B, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2015 Apr 15;191(8):902-13. doi: 10.1164/rccm.201409-1610OC. Am J Respir Crit Care Med. 2015. PMID: 25607238 Free PMC article.
The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.
Turner MJ, Matthes E, Billet A, Ferguson AJ, Thomas DY, Randell SH, Ostrowski LE, Abbott-Banner K, Hanrahan JW. Turner MJ, et al. Among authors: randell sh. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70. doi: 10.1152/ajplung.00324.2015. Epub 2015 Nov 6. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26545902 Free article.
Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium.
Marozkina N, Bosch J, Cotton C, Smith L, Seckler J, Zaman K, Rehman S, Periasamy A, Gaston H, Altawallbeh G, Davis M, Jones DR, Schilz R, Randell SH, Gaston B. Marozkina N, et al. Among authors: randell sh. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L247-L258. doi: 10.1152/ajplung.00020.2019. Epub 2019 May 22. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31116581 Free PMC article.
Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs.
Carraro G, Mulay A, Yao C, Mizuno T, Konda B, Petrov M, Lafkas D, Arron JR, Hogaboam CM, Chen P, Jiang D, Noble PW, Randell SH, McQualter JL, Stripp BR. Carraro G, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2020 Dec 1;202(11):1540-1550. doi: 10.1164/rccm.201904-0792OC. Am J Respir Crit Care Med. 2020. PMID: 32692579 Free PMC article.
Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research.
Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah F, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KCK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy CEY, Najarian M, O'Brien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraswatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JK, Williams L, Zylka MJ, Ferris MT, McMillan L, Manuel de Villena FP. Sigmon JS, et al. Among authors: randell sh. Genetics. 2020 Dec;216(4):905-930. doi: 10.1534/genetics.120.303596. Epub 2020 Oct 16. Genetics. 2020. PMID: 33067325 Free PMC article.
Making More MUCS.
Perez-Vilar J, Sheehan JK, Randell SH. Perez-Vilar J, et al. Among authors: randell sh. Am J Respir Cell Mol Biol. 2003 Mar;28(3):267-70. doi: 10.1165/rcmb.F262. Am J Respir Cell Mol Biol. 2003. PMID: 12594051 Review. No abstract available.
Airway epithelia.
Johnson LG, Randell SH, Olsen JC. Johnson LG, et al. Among authors: randell sh. Methods Mol Biol. 2003;229:181-96. doi: 10.1385/1-59259-393-3:181. Methods Mol Biol. 2003. PMID: 12824631 Free PMC article.
Augmentation of CFTR maturation by S-nitrosoglutathione reductase.
Zaman K, Sawczak V, Zaidi A, Butler M, Bennett D, Getsy P, Zeinomar M, Greenberg Z, Forbes M, Rehman S, Jyothikumar V, DeRonde K, Sattar A, Smith L, Corey D, Straub A, Sun F, Palmer L, Periasamy A, Randell S, Kelley TJ, Lewis SJ, Gaston B. Zaman K, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L263-70. doi: 10.1152/ajplung.00269.2014. Epub 2015 Dec 4. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26637637 Free PMC article.
Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.
Gentzsch M, Ren HY, Houck SA, Quinney NL, Cholon DM, Sopha P, Chaudhry IG, Das J, Dokholyan NV, Randell SH, Cyr DM. Gentzsch M, et al. Among authors: randell sh. Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L550-9. doi: 10.1152/ajplung.00186.2016. Epub 2016 Jul 8. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27402691 Free PMC article.
Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction.
Suzuki S, Crane AM, Anirudhan V, Barillà C, Matthias N, Randell SH, Rab A, Sorscher EJ, Kerschner JL, Yin S, Harris A, Mendel M, Kim K, Zhang L, Conway A, Davis BR. Suzuki S, et al. Among authors: randell sh. Mol Ther. 2020 Jul 8;28(7):1684-1695. doi: 10.1016/j.ymthe.2020.04.021. Epub 2020 Apr 29. Mol Ther. 2020. PMID: 32402246 Free PMC article.
Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells.
Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu X, Yuan H, Cheluvaraju C, Clapp PW, Boucher RC Jr, Kamonjoh CM, Randell SH, Schlegel R. Suprynowicz FA, et al. Among authors: randell sh. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20035-40. doi: 10.1073/pnas.1213241109. Epub 2012 Nov 19. Proc Natl Acad Sci U S A. 2012. PMID: 23169653 Free PMC article.
A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.
Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q. Panganiban RA, et al. Among authors: randell sh. J Allergy Clin Immunol. 2018 Nov;142(5):1469-1478.e2. doi: 10.1016/j.jaci.2017.11.040. Epub 2018 Jan 9. J Allergy Clin Immunol. 2018. PMID: 29330013 Free PMC article.
Mechanical forces induce an asthma gene signature in healthy airway epithelial cells.
Kılıç A, Ameli A, Park JA, Kho AT, Tantisira K, Santolini M, Cheng F, Mitchel JA, McGill M, O'Sullivan MJ, De Marzio M, Sharma A, Randell SH, Drazen JM, Fredberg JJ, Weiss ST. Kılıç A, et al. Among authors: randell sh. Sci Rep. 2020 Jan 22;10(1):966. doi: 10.1038/s41598-020-57755-8. Sci Rep. 2020. PMID: 31969610 Free PMC article.
Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness.
Kong X, Bennett WC, Jania CM, Chason KD, German Z, Adouli J, Budney SD, Oby BT, van Heusden C, Lazarowski ER, Jaspers I, Randell SH, Hedgespeth BA, Cruse G, Hua X, Schworer SA, Smith GJ, Kelada SN, Tilley SL. Kong X, et al. Among authors: randell sh. JCI Insight. 2021 Nov 8;6(21):e140207. doi: 10.1172/jci.insight.140207. JCI Insight. 2021. PMID: 34546976 Free PMC article.
Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury.
Koukoulis G, Caldwell R, Inokawa H, Button B, Sevala M, Lyles JD, Takashima S, Blackwell J, Randell SH, Egan TM. Koukoulis G, et al. Among authors: randell sh. J Heart Lung Transplant. 2005 Dec;24(12):2218-25. doi: 10.1016/j.healun.2005.06.009. Epub 2005 Nov 17. J Heart Lung Transplant. 2005. PMID: 16364874
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA. Chen G, et al. Among authors: randell sh. Am J Respir Crit Care Med. 2014 Feb 1;189(3):301-13. doi: 10.1164/rccm.201306-1181OC. Am J Respir Crit Care Med. 2014. PMID: 24392884 Free PMC article.
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells.
Hawkins FJ, Suzuki S, Beermann ML, Barillà C, Wang R, Villacorta-Martin C, Berical A, Jean JC, Le Suer J, Matte T, Simone-Roach C, Tang Y, Schlaeger TM, Crane AM, Matthias N, Huang SXL, Randell SH, Wu J, Spence JR, Carraro G, Stripp BR, Rab A, Sorsher EJ, Horani A, Brody SL, Davis BR, Kotton DN. Hawkins FJ, et al. Among authors: randell sh. Cell Stem Cell. 2021 Jan 7;28(1):79-95.e8. doi: 10.1016/j.stem.2020.09.017. Epub 2020 Oct 23. Cell Stem Cell. 2021. PMID: 33098807 Free PMC article.
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