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Page 1
Cellular signaling by fibroblast growth factor receptors.
Eswarakumar VP, Lax I, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49. doi: 10.1016/j.cytogfr.2005.01.001. Epub 2005 Feb 1. Cytokine Growth Factor Rev. 2005. PMID: 15863030 Review.
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.
Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J. Gotoh N, et al. Among authors: schlessinger j. Mol Cell Biol. 2005 May;25(10):4105-16. doi: 10.1128/MCB.25.10.4105-4116.2005. Mol Cell Biol. 2005. PMID: 15870281 Free PMC article.
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.
Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N. Yamamoto S, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15983-8. doi: 10.1073/pnas.0507961102. Epub 2005 Oct 20. Proc Natl Acad Sci U S A. 2005. PMID: 16239343 Free PMC article.
On the nature of low- and high-affinity EGF receptors on living cells.
Ozcan F, Klein P, Lemmon MA, Lax I, Schlessinger J. Ozcan F, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5735-40. doi: 10.1073/pnas.0601469103. Epub 2006 Mar 29. Proc Natl Acad Sci U S A. 2006. PMID: 16571657 Free PMC article.
Surface binding inhibitors of the SCF-KIT protein-protein interaction.
Margulies D, Opatowsky Y, Fletcher S, Saraogi I, Tsou LK, Saha S, Lax I, Schlessinger J, Hamilton AD. Margulies D, et al. Among authors: schlessinger j. Chembiochem. 2009 Aug 17;10(12):1955-8. doi: 10.1002/cbic.200900079. Chembiochem. 2009. PMID: 19637142 Free PMC article. No abstract available.
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Ha BH, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12. doi: 10.1073/pnas.1214447109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988085 Free PMC article.
RAC1P29S is a spontaneously activating cancer-associated GTPase.
Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ. Davis MJ, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):912-7. doi: 10.1073/pnas.1220895110. Epub 2013 Jan 2. Proc Natl Acad Sci U S A. 2013. PMID: 23284172 Free PMC article.
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.
Zhao S, Choi M, Overton JD, Bellone S, Roque DM, Cocco E, Guzzo F, English DP, Varughese J, Gasparrini S, Bortolomai I, Buza N, Hui P, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Carrara L, Pecorelli S, Silasi DA, Ratner E, Azodi M, Schwartz PE, Rutherford TJ, Stiegler AL, Mane S, Boggon TJ, Schlessinger J, Lifton RP, Santin AD. Zhao S, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2916-21. doi: 10.1073/pnas.1222577110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359684 Free PMC article.
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17832-7. doi: 10.1073/pnas.1317118110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127596 Free PMC article.
The docking protein FRS2α is a critical regulator of VEGF receptors signaling.
Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. Chen PY, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5514-9. doi: 10.1073/pnas.1404545111. Epub 2014 Apr 2. Proc Natl Acad Sci U S A. 2014. PMID: 24706887 Free PMC article.
Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
Murray PB, Lax I, Reshetnyak A, Ligon GF, Lillquist JS, Natoli EJ Jr, Shi X, Folta-Stogniew E, Gunel M, Alvarado D, Schlessinger J. Murray PB, et al. Among authors: schlessinger j. Sci Signal. 2015 Jan 20;8(360):ra6. doi: 10.1126/scisignal.2005916. Sci Signal. 2015. PMID: 25605972
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15862-7. doi: 10.1073/pnas.1520099112. Epub 2015 Nov 16. Proc Natl Acad Sci U S A. 2015. PMID: 26630010 Free PMC article.
Early and multiple origins of metastatic lineages within primary tumors.
Zhao ZM, Zhao B, Bai Y, Iamarino A, Gaffney SG, Schlessinger J, Lifton RP, Rimm DL, Townsend JP. Zhao ZM, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2140-5. doi: 10.1073/pnas.1525677113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858460 Free PMC article.
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.
Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Shi X, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66. doi: 10.1073/pnas.1608319113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432991 Free PMC article.
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Reshetnyak AV, Mohanty J, Tomé F, Puleo DE, Plotnikov AN, Ahmed M, Kaur N, Poliakov A, Cinnaiyan AM, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8340-8345. doi: 10.1073/pnas.1807881115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061385 Free PMC article.
Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors.
Li C, Bonazzoli E, Bellone S, Choi J, Dong W, Menderes G, Altwerger G, Han C, Manzano A, Bianchi A, Pettinella F, Manara P, Lopez S, Yadav G, Riccio F, Zammataro L, Zeybek B, Yang-Hartwich Y, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Zizioli V, Odicino F, Pecorelli S, Ardighieri L, Silasi DA, Litkouhi B, Ratner E, Azodi M, Huang GS, Schwartz PE, Lifton RP, Schlessinger J, Santin AD. Li C, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):619-624. doi: 10.1073/pnas.1814027116. Epub 2018 Dec 24. Proc Natl Acad Sci U S A. 2019. PMID: 30584090 Free PMC article.
Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Kuzina ES, Ung PM, Mohanty J, Tome F, Choi J, Pardon E, Steyaert J, Lax I, Schlessinger A, Schlessinger J, Lee S. Kuzina ES, et al. Among authors: schlessinger j, schlessinger a. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7819-7824. doi: 10.1073/pnas.1822055116. Epub 2019 Apr 3. Proc Natl Acad Sci U S A. 2019. PMID: 30944224 Free PMC article.
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
Zammataro L, Lopez S, Bellone S, Pettinella F, Bonazzoli E, Perrone E, Zhao S, Menderes G, Altwerger G, Han C, Zeybek B, Bianchi A, Manzano A, Manara P, Cocco E, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Angioli R, Raspagliesi F, Scambia G, Choi J, Dong W, Bilguvar K, Alexandrov LB, Silasi DA, Huang GS, Ratner E, Azodi M, Schwartz PE, Pirazzoli V, Stiegler AL, Boggon TJ, Lifton RP, Schlessinger J, Santin AD. Zammataro L, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22730-22736. doi: 10.1073/pnas.1911385116. Epub 2019 Oct 17. Proc Natl Acad Sci U S A. 2019. PMID: 31624127 Free PMC article.
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.
Liosi ME, Krimmer SG, Newton AS, Dawson TK, Puleo DE, Cutrona KJ, Suzuki Y, Schlessinger J, Jorgensen WL. Liosi ME, et al. Among authors: schlessinger j. J Med Chem. 2020 May 28;63(10):5324-5340. doi: 10.1021/acs.jmedchem.0c00192. Epub 2020 May 8. J Med Chem. 2020. PMID: 32329617 Free PMC article.
Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Zhou M, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31914-31922. doi: 10.1073/pnas.2005712117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257571 Free PMC article.
Integrated mutational landscape analysis of uterine leiomyosarcomas.
Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Choi J, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025182118. doi: 10.1073/pnas.2025182118. Proc Natl Acad Sci U S A. 2021. PMID: 33876771 Free PMC article.
Structural basis for ligand reception by anaplastic lymphoma kinase.
Li T, Stayrook SE, Tsutsui Y, Zhang J, Wang Y, Li H, Proffitt A, Krimmer SG, Ahmed M, Belliveau O, Walker IX, Mudumbi KC, Suzuki Y, Lax I, Alvarado D, Lemmon MA, Schlessinger J, Klein DE. Li T, et al. Among authors: schlessinger j. Nature. 2021 Dec;600(7887):148-152. doi: 10.1038/s41586-021-04141-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819665 Free PMC article.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG. Reshetnyak AV, et al. Among authors: schlessinger j. Nature. 2021 Dec;600(7887):153-157. doi: 10.1038/s41586-021-04140-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819673 Free PMC article.
Design of protein-binding proteins from the target structure alone.
Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Cao L, et al. Among authors: schlessinger j. Nature. 2022 May;605(7910):551-560. doi: 10.1038/s41586-022-04654-9. Epub 2022 Mar 24. Nature. 2022. PMID: 35332283 Free PMC article.
A hypothalamic pathway for Augmentor α-controlled body weight regulation.
Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J. Ahmed M, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2200476119. doi: 10.1073/pnas.2200476119. Epub 2022 Apr 11. Proc Natl Acad Sci U S A. 2022. PMID: 35412887 Free PMC article.
600 results