Schlessinger J - Search Results

1

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.

Suzuki Y, Kuzina E, An SJ, Tome F, Mohanty J, Li W, Lee S, Liu Y, Lax I, Schlessinger J. Suzuki Y, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31800-31807. doi: 10.1073/pnas.2018554117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257569 Free PMC article.

2

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J. Li W, et al. Among authors: schlessinger j. Mol Cell Biol. 1992 Dec;12(12):5824-33. doi: 10.1128/mcb.12.12.5824-5833.1992. Mol Cell Biol. 1992. PMID: 1333047 Free PMC article.

3

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

Spivak-Kroizman T, Rotin D, Pinchasi D, Ullrich A, Schlessinger J, Lax I. Spivak-Kroizman T, et al. Among authors: schlessinger j. J Biol Chem. 1992 Apr 25;267(12):8056-63. J Biol Chem. 1992. PMID: 1349015 Free article.

4

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.

Mohammadi M, Dionne CA, Li W, Li N, Spivak T, Honegger AM, Jaye M, Schlessinger J. Mohammadi M, et al. Among authors: schlessinger j. Nature. 1992 Aug 20;358(6388):681-4. doi: 10.1038/358681a0. Nature. 1992. PMID: 1379698

5

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.

Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Margolis B, et al. Among authors: schlessinger j. Nature. 1992 Mar 5;356(6364):71-4. doi: 10.1038/356071a0. Nature. 1992. PMID: 1531699

6

Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.

Li W, Schlessinger J. Li W, et al. Among authors: schlessinger j. Mol Cell Biol. 1991 Jul;11(7):3756-61. doi: 10.1128/mcb.11.7.3756-3761.1991. Mol Cell Biol. 1991. PMID: 1646395 Free PMC article.

7

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

Mohammadi M, Honegger AM, Rotin D, Fischer R, Bellot F, Li W, Dionne CA, Jaye M, Rubinstein M, Schlessinger J. Mohammadi M, et al. Among authors: schlessinger j. Mol Cell Biol. 1991 Oct;11(10):5068-78. doi: 10.1128/mcb.11.10.5068-5078.1991. Mol Cell Biol. 1991. PMID: 1656221 Free PMC article.

8

Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.

Li W, Hack N, Margolis B, Ullrich A, Skorecki K, Schlessinger J. Li W, et al. Among authors: schlessinger j. Cell Regul. 1991 Aug;2(8):641-9. doi: 10.1091/mbc.2.8.641. Cell Regul. 1991. PMID: 1777506 Free PMC article.

9

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.

Lax I, Mitra AK, Ravera C, Hurwitz DR, Rubinstein M, Ullrich A, Stroud RM, Schlessinger J. Lax I, et al. Among authors: schlessinger j. J Biol Chem. 1991 Jul 25;266(21):13828-33. J Biol Chem. 1991. PMID: 1856216 Free article.

10

Comparison of EGF receptor sequences as a guide to study the ligand binding site.

Avivi A, Lax I, Ullrich A, Schlessinger J, Givol D, Morse B. Avivi A, et al. Among authors: schlessinger j. Oncogene. 1991 Apr;6(4):673-6. Oncogene. 1991. PMID: 2030916

11

Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

Lax I, Bellot F, Honegger AM, Schmidt A, Ullrich A, Givol D, Schlessinger J. Lax I, et al. Among authors: schlessinger j. Cell Regul. 1990 Jan;1(2):173-88. doi: 10.1091/mbc.1.2.173. Cell Regul. 1990. PMID: 2100196 Free PMC article.

12

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

Lee J, Dull TJ, Lax I, Schlessinger J, Ullrich A. Lee J, et al. Among authors: schlessinger j. EMBO J. 1989 Jan;8(1):167-73. doi: 10.1002/j.1460-2075.1989.tb03361.x. EMBO J. 1989. PMID: 2565808 Free PMC article.

13

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

Lax I, Burgess WH, Bellot F, Ullrich A, Schlessinger J, Givol D. Lax I, et al. Among authors: schlessinger j. Mol Cell Biol. 1988 Apr;8(4):1831-4. doi: 10.1128/mcb.8.4.1831-1834.1988. Mol Cell Biol. 1988. PMID: 3260004 Free PMC article.

14

Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3).

Hapgood J, Libermann TA, Lax I, Yarden Y, Schreiber AB, Naor Z, Schlessinger J. Hapgood J, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6451-5. doi: 10.1073/pnas.80.21.6451. Proc Natl Acad Sci U S A. 1983. PMID: 6195656 Free PMC article.

15

Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system.

Lax I, Bar-Eli M, Yarden Y, Libermann TA, Schlessinger J. Lax I, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1984 Oct;81(19):5911-5. doi: 10.1073/pnas.81.19.5911. Proc Natl Acad Sci U S A. 1984. PMID: 6207534 Free PMC article.

16

Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor.

Schreiber AB, Lax I, Yarden Y, Eshhar Z, Schlessinger J. Schreiber AB, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7535-9. doi: 10.1073/pnas.78.12.7535. Proc Natl Acad Sci U S A. 1981. PMID: 6278478 Free PMC article.

17

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

Lemmon MA, Ferguson KM, O'Brien R, Sigler PB, Schlessinger J. Lemmon MA, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10472-6. doi: 10.1073/pnas.92.23.10472. Proc Natl Acad Sci U S A. 1995. PMID: 7479822 Free PMC article.

18

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I. Spivak-Kroizman T, et al. Among authors: schlessinger j. J Biol Chem. 1994 May 20;269(20):14419-23. J Biol Chem. 1994. PMID: 7514169 Free article.

19

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.

Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I. Spivak-Kroizman T, et al. Among authors: schlessinger j. Cell. 1994 Dec 16;79(6):1015-24. doi: 10.1016/0092-8674(94)90032-9. Cell. 1994. PMID: 7528103

20

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

Ladbury JE, Lemmon MA, Zhou M, Green J, Botfield MC, Schlessinger J. Ladbury JE, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3199-203. doi: 10.1073/pnas.92.8.3199. Proc Natl Acad Sci U S A. 1995. PMID: 7536927 Free PMC article.

21

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J, Schlessinger J. Nishimura R, et al. Among authors: schlessinger j. Mol Cell Biol. 1993 Nov;13(11):6889-96. doi: 10.1128/mcb.13.11.6889-6896.1993. Mol Cell Biol. 1993. PMID: 7692233 Free PMC article.

22

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation.

Dikic I, Schlessinger J, Lax I. Dikic I, et al. Among authors: schlessinger j. Curr Biol. 1994 Aug 1;4(8):702-8. doi: 10.1016/s0960-9822(00)00155-x. Curr Biol. 1994. PMID: 7953556

23

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

McPherson PS, Czernik AJ, Chilcote TJ, Onofri F, Benfenati F, Greengard P, Schlessinger J, De Camilli P. McPherson PS, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6486-90. doi: 10.1073/pnas.91.14.6486. Proc Natl Acad Sci U S A. 1994. PMID: 8022809 Free PMC article.

24

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

Li W, Nishimura R, Kashishian A, Batzer AG, Kim WJ, Cooper JA, Schlessinger J. Li W, et al. Among authors: schlessinger j. Mol Cell Biol. 1994 Jan;14(1):509-17. doi: 10.1128/mcb.14.1.509-517.1994. Mol Cell Biol. 1994. PMID: 8264620 Free PMC article.

25

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

Lee CH, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG Jr, White MF, Schlessinger J, Skolnik EY. Lee CH, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11713-7. doi: 10.1073/pnas.90.24.11713. Proc Natl Acad Sci U S A. 1993. PMID: 8265614 Free PMC article.

26

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation.

Zhou M, Felder S, Rubinstein M, Hurwitz DR, Ullrich A, Lax I, Schlessinger J. Zhou M, et al. Among authors: schlessinger j. Biochemistry. 1993 Aug 17;32(32):8193-8. doi: 10.1021/bi00083a020. Biochemistry. 1993. PMID: 8347619

27

Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

Schlessinger J, Lax I, Lemmon M. Schlessinger J, et al. Cell. 1995 Nov 3;83(3):357-60. doi: 10.1016/0092-8674(95)90112-4. Cell. 1995. PMID: 8521464 Free article. Review. No abstract available.

28

Two EGF molecules contribute additively to stabilization of the EGFR dimer.

Lemmon MA, Bu Z, Ladbury JE, Zhou M, Pinchasi D, Lax I, Engelman DM, Schlessinger J. Lemmon MA, et al. Among authors: schlessinger j. EMBO J. 1997 Jan 15;16(2):281-94. doi: 10.1093/emboj/16.2.281. EMBO J. 1997. PMID: 9029149 Free PMC article.

29

Kit receptor dimerization is driven by bivalent binding of stem cell factor.

Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J. Lemmon MA, et al. Among authors: schlessinger j. J Biol Chem. 1997 Mar 7;272(10):6311-7. doi: 10.1074/jbc.272.10.6311. J Biol Chem. 1997. PMID: 9045650 Free article.

30

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.

Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J. Kouhara H, et al. Among authors: schlessinger j. Cell. 1997 May 30;89(5):693-702. doi: 10.1016/s0092-8674(00)80252-4. Cell. 1997. PMID: 9182757 Free article.

31

Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor.

Odaka M, Kohda D, Lax I, Schlessinger J, Inagaki F. Odaka M, et al. Among authors: schlessinger j. J Biochem. 1997 Jul;122(1):116-21. doi: 10.1093/oxfordjournals.jbchem.a021718. J Biochem. 1997. PMID: 9276679 Free article.

32

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.

Hadari YR, Kouhara H, Lax I, Schlessinger J. Hadari YR, et al. Among authors: schlessinger j. Mol Cell Biol. 1998 Jul;18(7):3966-73. doi: 10.1128/MCB.18.7.3966. Mol Cell Biol. 1998. PMID: 9632781 Free PMC article.

33

Structure of a heparin-linked biologically active dimer of fibroblast growth factor.

DiGabriele AD, Lax I, Chen DI, Svahn CM, Jaye M, Schlessinger J, Hendrickson WA. DiGabriele AD, et al. Among authors: schlessinger j. Nature. 1998 Jun 25;393(6687):812-7. doi: 10.1038/31741. Nature. 1998. PMID: 9655399

34

Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse.

Moreno H, Nadal M, Leznik E, Sugimori M, Lax I, Schlessinger J, Llinás R. Moreno H, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14997-5002. doi: 10.1073/pnas.95.25.14997. Proc Natl Acad Sci U S A. 1998. PMID: 9844004 Free PMC article.

35

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.

Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I. Ong SH, et al. Among authors: schlessinger j. Mol Cell Biol. 2000 Feb;20(3):979-89. doi: 10.1128/MCB.20.3.979-989.2000. Mol Cell Biol. 2000. PMID: 10629055 Free PMC article.

36

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I. Ong SH, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6074-9. doi: 10.1073/pnas.111114298. Epub 2001 May 15. Proc Natl Acad Sci U S A. 2001. PMID: 11353842 Free PMC article.

37

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways.

Hadari YR, Gotoh N, Kouhara H, Lax I, Schlessinger J. Hadari YR, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8578-83. doi: 10.1073/pnas.161259898. Epub 2001 Jul 10. Proc Natl Acad Sci U S A. 2001. PMID: 11447289 Free PMC article.

38

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

Wong A, Lamothe B, Lee A, Schlessinger J, Lax I. Wong A, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6684-9. doi: 10.1073/pnas.052138899. Epub 2002 May 7. Proc Natl Acad Sci U S A. 2002. PMID: 11997436 Free PMC article.

39

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.

Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J. Lax I, et al. Among authors: schlessinger j. Mol Cell. 2002 Oct;10(4):709-19. doi: 10.1016/s1097-2765(02)00689-5. Mol Cell. 2002. PMID: 12419216 Free article.

40

Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration.

Okigaki M, Davis C, Falasca M, Harroch S, Felsenfeld DP, Sheetz MP, Schlessinger J. Okigaki M, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10740-5. doi: 10.1073/pnas.1834348100. Epub 2003 Sep 5. Proc Natl Acad Sci U S A. 2003. PMID: 12960403 Free PMC article.

41

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function.

Mattoon D, Klein P, Lemmon MA, Lax I, Schlessinger J. Mattoon D, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):923-8. doi: 10.1073/pnas.0307286101. Epub 2004 Jan 19. Proc Natl Acad Sci U S A. 2004. PMID: 14732693 Free PMC article.

42

A structure-based model for ligand binding and dimerization of EGF receptors.

Klein P, Mattoon D, Lemmon MA, Schlessinger J. Klein P, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):929-34. doi: 10.1073/pnas.0307285101. Epub 2004 Jan 19. Proc Natl Acad Sci U S A. 2004. PMID: 14732694 Free PMC article.

43

FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.

Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J. Gotoh N, et al. Among authors: schlessinger j. FEBS Lett. 2004 Apr 23;564(1-2):14-8. doi: 10.1016/S0014-5793(04)00287-X. FEBS Lett. 2004. PMID: 15094036 Free article.

44

The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.

Lamothe B, Yamada M, Schaeper U, Birchmeier W, Lax I, Schlessinger J. Lamothe B, et al. Among authors: schlessinger j. Mol Cell Biol. 2004 Jul;24(13):5657-66. doi: 10.1128/MCB.24.13.5657-5666.2004. Mol Cell Biol. 2004. PMID: 15199124 Free PMC article.

45

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway.

Mattoon DR, Lamothe B, Lax I, Schlessinger J. Mattoon DR, et al. Among authors: schlessinger j. BMC Biol. 2004 Nov 18;2:24. doi: 10.1186/1741-7007-2-24. BMC Biol. 2004. PMID: 15550174 Free PMC article.

46

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.

Gotoh N, Ito M, Yamamoto S, Yoshino I, Song N, Wang Y, Lax I, Schlessinger J, Shibuya M, Lang RA. Gotoh N, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17144-9. doi: 10.1073/pnas.0407577101. Epub 2004 Nov 29. Proc Natl Acad Sci U S A. 2004. PMID: 15569927 Free PMC article.

47

Cellular signaling by fibroblast growth factor receptors.

Eswarakumar VP, Lax I, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Cytokine Growth Factor Rev. 2005 Apr;16(2):139-49. doi: 10.1016/j.cytogfr.2005.01.001. Epub 2005 Feb 1. Cytokine Growth Factor Rev. 2005. PMID: 15863030 Review.

48

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.

Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J. Gotoh N, et al. Among authors: schlessinger j. Mol Cell Biol. 2005 May;25(10):4105-16. doi: 10.1128/MCB.25.10.4105-4116.2005. Mol Cell Biol. 2005. PMID: 15870281 Free PMC article.

49

Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.

Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N. Yamamoto S, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15983-8. doi: 10.1073/pnas.0507961102. Epub 2005 Oct 20. Proc Natl Acad Sci U S A. 2005. PMID: 16239343 Free PMC article.

50

Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains.

Yokote H, Fujita K, Jing X, Sawada T, Liang S, Yao L, Yan X, Zhang Y, Schlessinger J, Sakaguchi K. Yokote H, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18866-71. doi: 10.1073/pnas.0509741102. Epub 2005 Dec 19. Proc Natl Acad Sci U S A. 2005. PMID: 16365308 Free PMC article.

51

On the nature of low- and high-affinity EGF receptors on living cells.

Ozcan F, Klein P, Lemmon MA, Lax I, Schlessinger J. Ozcan F, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5735-40. doi: 10.1073/pnas.0601469103. Epub 2006 Mar 29. Proc Natl Acad Sci U S A. 2006. PMID: 16571657 Free PMC article.

52

Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.

Galisteo ML, Yang Y, Ureña J, Schlessinger J. Galisteo ML, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9796-801. doi: 10.1073/pnas.0603714103. Epub 2006 Jun 15. Proc Natl Acad Sci U S A. 2006. PMID: 16777958 Free PMC article.

53

Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis.

Eswarakumar VP, Ozcan F, Lew ED, Bae JH, Tomé F, Booth CJ, Adams DJ, Lax I, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18603-8. doi: 10.1073/pnas.0609157103. Epub 2006 Nov 28. Proc Natl Acad Sci U S A. 2006. PMID: 17132737 Free PMC article.

54

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.

Eswarakumar VP, Schlessinger J. Eswarakumar VP, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3937-42. doi: 10.1073/pnas.0700012104. Epub 2007 Feb 23. Proc Natl Acad Sci U S A. 2007. PMID: 17360456 Free PMC article.

55

Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.

Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J. Yuzawa S, et al. Among authors: schlessinger j. Cell. 2007 Jul 27;130(2):323-34. doi: 10.1016/j.cell.2007.05.055. Cell. 2007. PMID: 17662946 Free article.

56

Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.

Shams I, Rohmann E, Eswarakumar VP, Lew ED, Yuzawa S, Wollnik B, Schlessinger J, Lax I. Shams I, et al. Among authors: schlessinger j. Mol Cell Biol. 2007 Oct;27(19):6903-12. doi: 10.1128/MCB.00544-07. Epub 2007 Aug 6. Mol Cell Biol. 2007. PMID: 17682060 Free PMC article.

57

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.

Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J. Lew ED, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19802-7. doi: 10.1073/pnas.0709905104. Epub 2007 Dec 3. Proc Natl Acad Sci U S A. 2007. PMID: 18056630 Free PMC article.

58

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization.

Yang Y, Yuzawa S, Schlessinger J. Yang Y, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7681-6. doi: 10.1073/pnas.0802896105. Epub 2008 May 27. Proc Natl Acad Sci U S A. 2008. PMID: 18505839 Free PMC article.

59

Surface binding inhibitors of the SCF-KIT protein-protein interaction.

Margulies D, Opatowsky Y, Fletcher S, Saraogi I, Tsou LK, Saha S, Lax I, Schlessinger J, Hamilton AD. Margulies D, et al. Among authors: schlessinger j. Chembiochem. 2009 Aug 17;10(12):1955-8. doi: 10.1002/cbic.200900079. Chembiochem. 2009. PMID: 19637142 Free PMC article. No abstract available.

60

The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.

Bae JH, Lew ED, Yuzawa S, Tomé F, Lax I, Schlessinger J. Bae JH, et al. Among authors: schlessinger j. Cell. 2009 Aug 7;138(3):514-24. doi: 10.1016/j.cell.2009.05.028. Cell. 2009. PMID: 19665973 Free PMC article.

61

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling.

Yang Y, Xie P, Opatowsky Y, Schlessinger J. Yang Y, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1906-11. doi: 10.1073/pnas.0914052107. Epub 2010 Jan 11. Proc Natl Acad Sci U S A. 2010. PMID: 20080685 Free PMC article.

62

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.

Bae JH, Boggon TJ, Tomé F, Mandiyan V, Lax I, Schlessinger J. Bae JH, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2866-71. doi: 10.1073/pnas.0914157107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133753 Free PMC article.

63

FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.

Sato T, Shimazaki T, Naka H, Fukami S, Satoh Y, Okano H, Lax I, Schlessinger J, Gotoh N. Sato T, et al. Among authors: schlessinger j. Stem Cells. 2010 Sep;28(9):1661-73. doi: 10.1002/stem.488. Stem Cells. 2010. PMID: 20652960 Free PMC article.

64

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.

Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Sousa LP, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4419-24. doi: 10.1073/pnas.1200164109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371560 Free PMC article.

65

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.

Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Ha BH, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12. doi: 10.1073/pnas.1214447109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988085 Free PMC article.

66

RAC1P29S is a spontaneously activating cancer-associated GTPase.

Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ. Davis MJ, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):912-7. doi: 10.1073/pnas.1220895110. Epub 2013 Jan 2. Proc Natl Acad Sci U S A. 2013. PMID: 23284172 Free PMC article.

67

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.

Zhao S, Choi M, Overton JD, Bellone S, Roque DM, Cocco E, Guzzo F, English DP, Varughese J, Gasparrini S, Bortolomai I, Buza N, Hui P, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Carrara L, Pecorelli S, Silasi DA, Ratner E, Azodi M, Schwartz PE, Rutherford TJ, Stiegler AL, Mane S, Boggon TJ, Schlessinger J, Lifton RP, Santin AD. Zhao S, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2916-21. doi: 10.1073/pnas.1222577110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359684 Free PMC article.

68

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.

Reshetnyak AV, Nelson B, Shi X, Boggon TJ, Pavlenco A, Mandel-Bausch EM, Tome F, Suzuki Y, Sidhu SS, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17832-7. doi: 10.1073/pnas.1317118110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127596 Free PMC article.

69

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers.

Opatowsky Y, Lax I, Tomé F, Bleichert F, Unger VM, Schlessinger J. Opatowsky Y, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1772-7. doi: 10.1073/pnas.1323254111. Epub 2014 Jan 21. Proc Natl Acad Sci U S A. 2014. PMID: 24449920 Free PMC article.

70

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. Chen PY, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5514-9. doi: 10.1073/pnas.1404545111. Epub 2014 Apr 2. Proc Natl Acad Sci U S A. 2014. PMID: 24706887 Free PMC article.

71

Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G. Lew ED, et al. Among authors: schlessinger j. Elife. 2014 Sep 29;3:e03385. doi: 10.7554/eLife.03385. Elife. 2014. PMID: 25265470 Free PMC article.

72

The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.

Reshetnyak AV, Opatowsky Y, Boggon TJ, Folta-Stogniew E, Tome F, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Mol Cell. 2015 Jan 8;57(1):191-201. doi: 10.1016/j.molcel.2014.11.021. Epub 2014 Dec 24. Mol Cell. 2015. PMID: 25544564 Free PMC article.

73

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.

Murray PB, Lax I, Reshetnyak A, Ligon GF, Lillquist JS, Natoli EJ Jr, Shi X, Folta-Stogniew E, Gunel M, Alvarado D, Schlessinger J. Murray PB, et al. Among authors: schlessinger j. Sci Signal. 2015 Jan 20;8(360):ra6. doi: 10.1126/scisignal.2005916. Sci Signal. 2015. PMID: 25605972

74

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

Perry RJ, Lee S, Ma L, Zhang D, Schlessinger J, Shulman GI. Perry RJ, et al. Among authors: schlessinger j. Nat Commun. 2015 Apr 28;6:6980. doi: 10.1038/ncomms7980. Nat Commun. 2015. PMID: 25916467 Free PMC article.

75

Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration.

Lee S, Greenlee EB, Amick JR, Ligon GF, Lillquist JS, Natoli EJ Jr, Hadari Y, Alvarado D, Schlessinger J. Lee S, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13225-30. doi: 10.1073/pnas.1518361112. Epub 2015 Oct 12. Proc Natl Acad Sci U S A. 2015. PMID: 26460020 Free PMC article.

76

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.

Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15862-7. doi: 10.1073/pnas.1520099112. Epub 2015 Nov 16. Proc Natl Acad Sci U S A. 2015. PMID: 26630010 Free PMC article.

77

Early and multiple origins of metastatic lineages within primary tumors.

Zhao ZM, Zhao B, Bai Y, Iamarino A, Gaffney SG, Schlessinger J, Lifton RP, Rimm DL, Townsend JP. Zhao ZM, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2140-5. doi: 10.1073/pnas.1525677113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858460 Free PMC article.

78

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.

Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Shi X, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66. doi: 10.1073/pnas.1608319113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432991 Free PMC article.

79

Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition.

Shi X, Sousa LP, Mandel-Bausch EM, Tome F, Reshetnyak AV, Hadari Y, Schlessinger J, Lax I. Shi X, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4784-93. doi: 10.1073/pnas.1610179113. Epub 2016 Aug 1. Proc Natl Acad Sci U S A. 2016. PMID: 27482095 Free PMC article.

80

Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk.

Mo ES, Cheng Q, Reshetnyak AV, Schlessinger J, Nicoli S. Mo ES, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12027-12032. doi: 10.1073/pnas.1710254114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078341 Free PMC article.

81

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.

Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J. Lee S, et al. Among authors: schlessinger j. Nature. 2018 Jan 25;553(7689):501-505. doi: 10.1038/nature25010. Epub 2018 Jan 17. Nature. 2018. PMID: 29342135 Free PMC article.

82

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).

Reshetnyak AV, Mohanty J, Tomé F, Puleo DE, Plotnikov AN, Ahmed M, Kaur N, Poliakov A, Cinnaiyan AM, Lax I, Schlessinger J. Reshetnyak AV, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8340-8345. doi: 10.1073/pnas.1807881115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061385 Free PMC article.

83

Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors.

Li C, Bonazzoli E, Bellone S, Choi J, Dong W, Menderes G, Altwerger G, Han C, Manzano A, Bianchi A, Pettinella F, Manara P, Lopez S, Yadav G, Riccio F, Zammataro L, Zeybek B, Yang-Hartwich Y, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Zizioli V, Odicino F, Pecorelli S, Ardighieri L, Silasi DA, Litkouhi B, Ratner E, Azodi M, Huang GS, Schwartz PE, Lifton RP, Schlessinger J, Santin AD. Li C, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):619-624. doi: 10.1073/pnas.1814027116. Epub 2018 Dec 24. Proc Natl Acad Sci U S A. 2019. PMID: 30584090 Free PMC article.

84

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.

Kuzina ES, Ung PM, Mohanty J, Tome F, Choi J, Pardon E, Steyaert J, Lax I, Schlessinger A, Schlessinger J, Lee S. Kuzina ES, et al. Among authors: schlessinger j, schlessinger a. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7819-7824. doi: 10.1073/pnas.1822055116. Epub 2019 Apr 3. Proc Natl Acad Sci U S A. 2019. PMID: 30944224 Free PMC article.

85

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.

Zammataro L, Lopez S, Bellone S, Pettinella F, Bonazzoli E, Perrone E, Zhao S, Menderes G, Altwerger G, Han C, Zeybek B, Bianchi A, Manzano A, Manara P, Cocco E, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Angioli R, Raspagliesi F, Scambia G, Choi J, Dong W, Bilguvar K, Alexandrov LB, Silasi DA, Huang GS, Ratner E, Azodi M, Schwartz PE, Pirazzoli V, Stiegler AL, Boggon TJ, Lifton RP, Schlessinger J, Santin AD. Zammataro L, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22730-22736. doi: 10.1073/pnas.1911385116. Epub 2019 Oct 17. Proc Natl Acad Sci U S A. 2019. PMID: 31624127 Free PMC article.

86

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.

Liosi ME, Krimmer SG, Newton AS, Dawson TK, Puleo DE, Cutrona KJ, Suzuki Y, Schlessinger J, Jorgensen WL. Liosi ME, et al. Among authors: schlessinger j. J Med Chem. 2020 May 28;63(10):5324-5340. doi: 10.1021/acs.jmedchem.0c00192. Epub 2020 May 8. J Med Chem. 2020. PMID: 32329617 Free PMC article.

87

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.

Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Zhou M, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31914-31922. doi: 10.1073/pnas.2005712117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257571 Free PMC article.

88

Integrated mutational landscape analysis of uterine leiomyosarcomas.

Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Choi J, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025182118. doi: 10.1073/pnas.2025182118. Proc Natl Acad Sci U S A. 2021. PMID: 33876771 Free PMC article.

89

Structural basis for ligand reception by anaplastic lymphoma kinase.

Li T, Stayrook SE, Tsutsui Y, Zhang J, Wang Y, Li H, Proffitt A, Krimmer SG, Ahmed M, Belliveau O, Walker IX, Mudumbi KC, Suzuki Y, Lax I, Alvarado D, Lemmon MA, Schlessinger J, Klein DE. Li T, et al. Among authors: schlessinger j. Nature. 2021 Dec;600(7887):148-152. doi: 10.1038/s41586-021-04141-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819665 Free PMC article.

90

Mechanism for the activation of the anaplastic lymphoma kinase receptor.

Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG. Reshetnyak AV, et al. Among authors: schlessinger j. Nature. 2021 Dec;600(7887):153-157. doi: 10.1038/s41586-021-04140-8. Epub 2021 Nov 24. Nature. 2021. PMID: 34819673 Free PMC article.

91

Design of protein-binding proteins from the target structure alone.

Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Cao L, et al. Among authors: schlessinger j. Nature. 2022 May;605(7910):551-560. doi: 10.1038/s41586-022-04654-9. Epub 2022 Mar 24. Nature. 2022. PMID: 35332283 Free PMC article.

92

A hypothalamic pathway for Augmentor α-controlled body weight regulation.

Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J. Ahmed M, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2200476119. doi: 10.1073/pnas.2200476119. Epub 2022 Apr 11. Proc Natl Acad Sci U S A. 2022. PMID: 35412887 Free PMC article.

93

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.

Liosi ME, Ippolito JA, Henry SP, Krimmer SG, Newton AS, Cutrona KJ, Olivarez RA, Mohanty J, Schlessinger J, Jorgensen WL. Liosi ME, et al. Among authors: schlessinger j. J Med Chem. 2022 Jun 23;65(12):8380-8400. doi: 10.1021/acs.jmedchem.2c00283. Epub 2022 Jun 2. J Med Chem. 2022. PMID: 35653642 Free PMC article.

94

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis.

An SJ, Anneken A, Xi Z, Choi C, Schlessinger J, Toomre D. An SJ, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2208947119. doi: 10.1073/pnas.2208947119. Epub 2022 Nov 23. Proc Natl Acad Sci U S A. 2022. PMID: 36417441 Free PMC article.

95

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability.

An SJ, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J. An SJ, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2219128120. doi: 10.1073/pnas.2219128120. Epub 2023 Feb 6. Proc Natl Acad Sci U S A. 2023. PMID: 36745784 Free PMC article.

96

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.

Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J. Krimmer SG, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2300054120. doi: 10.1073/pnas.2300054120. Epub 2023 Mar 21. Proc Natl Acad Sci U S A. 2023. PMID: 36943885 Free PMC article.

97

Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α.

An S, Suzuki Y, Mohanty J, Tome F, Lax I, Schlessinger J. An S, et al. Among authors: schlessinger j. bioRxiv [Preprint]. 2025 Dec 13:2025.12.11.693497. doi: 10.64898/2025.12.11.693497. bioRxiv. 2025. PMID: 41415383 Free PMC article. Preprint.

98

Integrated mutational landscape analysis of endometrial stromal sarcoma.

Hartwich TMP, Choi S, Hwang A, Bellone S, Palmieri L, Seo H, Kim T, Hong J, Krakstad C, Trovik J, Stefansson IM, Haugland HK, Greenman M, Ettorre V, Ottum S, Demirkiran C, Yang-Hartwich Y, Buza N, Hui P, Lopez S, Cormio G, Ramunno M, Zito A, Perrone E, Fagotti A, Fanfani F, Santoro A, Ravaggi A, Bignotti E, Odicino F, Ardighieri L, Ratner E, Angioli R, Perrone G, Luvero D, Conca B, Choi J, Schlessinger J, Santin AD. Hartwich TMP, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 2026 Feb 3;123(5):e2531105123. doi: 10.1073/pnas.2531105123. Epub 2026 Jan 27. Proc Natl Acad Sci U S A. 2026. PMID: 41591910

99

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.

Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J. Lowenstein EJ, et al. Among authors: schlessinger j. Cell. 1992 Aug 7;70(3):431-42. doi: 10.1016/0092-8674(92)90167-b. Cell. 1992. PMID: 1322798 Free article.

100

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J. Margolis B, et al. Among authors: schlessinger j. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8. doi: 10.1073/pnas.89.19.8894. Proc Natl Acad Sci U S A. 1992. PMID: 1409582 Free PMC article.

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