Veit G - Search Results

1

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

Veit G, Roldan A, Hancock MA, Da Fonte DF, Xu H, Hussein M, Frenkiel S, Matouk E, Velkov T, Lukacs GL. Veit G, et al. JCI Insight. 2020 Sep 17;5(18):e139983. doi: 10.1172/jci.insight.139983. JCI Insight. 2020. PMID: 32853178 Free PMC article.

2

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.

Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL. Veit G, et al. Mol Biol Cell. 2012 Nov;23(21):4188-202. doi: 10.1091/mbc.E12-06-0424. Epub 2012 Sep 12. Mol Biol Cell. 2012. PMID: 22973054 Free PMC article.

3

Mechanism-based corrector combination restores ΔF508-CFTR folding and function.

Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Okiyoneda T, et al. Among authors: veit g. Nat Chem Biol. 2013 Jul;9(7):444-54. doi: 10.1038/nchembio.1253. Epub 2013 May 12. Nat Chem Biol. 2013. PMID: 23666117 Free PMC article.

4

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. Phuan PW, et al. Among authors: veit g. Mol Pharmacol. 2014 Jul;86(1):42-51. doi: 10.1124/mol.114.092478. Epub 2014 Apr 15. Mol Pharmacol. 2014. PMID: 24737137 Free PMC article.

5

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Veit G, et al. Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889. Sci Transl Med. 2014. PMID: 25101887 Free PMC article.

6

Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.

Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. Phuan PW, et al. Among authors: veit g. Mol Pharmacol. 2015 Oct;88(4):791-9. doi: 10.1124/mol.115.099689. Epub 2015 Aug 5. Mol Pharmacol. 2015. PMID: 26245207 Free PMC article.

7

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.

Veit G, Oliver K, Apaja PM, Perdomo D, Bidaud-Meynard A, Lin ST, Guo J, Icyuz M, Sorscher EJ, Hartman JL IV, Lukacs GL. Veit G, et al. PLoS Biol. 2016 May 11;14(5):e1002462. doi: 10.1371/journal.pbio.1002462. eCollection 2016 May. PLoS Biol. 2016. PMID: 27168400 Free PMC article.

8

Epithelial Anion Transport as Modulator of Chemokine Signaling.

Schnúr A, Hegyi P, Rousseau S, Lukacs GL, Veit G. Schnúr A, et al. Among authors: veit g. Mediators Inflamm. 2016;2016:7596531. doi: 10.1155/2016/7596531. Epub 2016 Jun 12. Mediators Inflamm. 2016. PMID: 27382190 Free PMC article. Review.

9

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Bagdany M, Veit G, Fukuda R, Avramescu RG, Okiyoneda T, Baaklini I, Singh J, Sovak G, Xu H, Apaja PM, Sattin S, Beitel LK, Roldan A, Colombo G, Balch W, Young JC, Lukacs GL. Bagdany M, et al. Among authors: veit g. Nat Commun. 2017 Aug 30;8(1):398. doi: 10.1038/s41467-017-00444-4. Nat Commun. 2017. PMID: 28855508 Free PMC article.

10

Mutation-specific downregulation of CFTR2 variants by gating potentiators.

Avramescu RG, Kai Y, Xu H, Bidaud-Meynard A, Schnúr A, Frenkiel S, Matouk E, Veit G, Lukacs GL. Avramescu RG, et al. Among authors: veit g. Hum Mol Genet. 2017 Dec 15;26(24):4873-4885. doi: 10.1093/hmg/ddx367. Hum Mol Genet. 2017. PMID: 29040544 Free PMC article.

11

Extracellular oxidation in cystic fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity.

Stolarczyk M, Veit G, Schnúr A, Veltman M, Lukacs GL, Scholte BJ. Stolarczyk M, et al. Among authors: veit g. Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L555-L568. doi: 10.1152/ajplung.00458.2017. Epub 2017 Dec 14. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29351448 Free article.

12

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase.

Okiyoneda T, Veit G, Sakai R, Aki M, Fujihara T, Higashi M, Susuki-Miyata S, Miyata M, Fukuda N, Yoshida A, Xu H, Apaja PM, Lukacs GL. Okiyoneda T, et al. Among authors: veit g. Dev Cell. 2018 Mar 26;44(6):694-708.e7. doi: 10.1016/j.devcel.2018.02.001. Epub 2018 Mar 1. Dev Cell. 2018. PMID: 29503157 Free PMC article.

13

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. Phuan PW, et al. Among authors: veit g. SLAS Discov. 2018 Sep;23(8):823-831. doi: 10.1177/2472555218763310. Epub 2018 Mar 13. SLAS Discov. 2018. PMID: 29533733 Free PMC article.

14

Structure-guided combination therapy to potently improve the function of mutant CFTRs.

Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL. Veit G, et al. Nat Med. 2018 Nov;24(11):1732-1742. doi: 10.1038/s41591-018-0200-x. Epub 2018 Oct 8. Nat Med. 2018. PMID: 30297908 Free PMC article.

15

Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting.

Bidaud-Meynard A, Bossard F, Schnúr A, Fukuda R, Veit G, Xu H, Lukacs GL. Bidaud-Meynard A, et al. Among authors: veit g. J Cell Sci. 2019 May 15;132(10):jcs226886. doi: 10.1242/jcs.226886. J Cell Sci. 2019. PMID: 30975917 Free PMC article.

16

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. Armirotti A, et al. Among authors: veit g. Sci Rep. 2019 Jul 16;9(1):10310. doi: 10.1038/s41598-019-46639-1. Sci Rep. 2019. PMID: 31311979 Free PMC article.

17

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants.

Veit G, Da Fonte DF, Avramescu RG, Premchandar A, Bagdany M, Xu H, Bensinger D, Stubba D, Schmidt B, Matouk E, Lukacs GL. Veit G, et al. J Cyst Fibros. 2020 Mar;19(2):236-244. doi: 10.1016/j.jcf.2019.10.011. Epub 2019 Oct 31. J Cyst Fibros. 2020. PMID: 31678009 Free PMC article.

18

Elexacaftor co-potentiates the activity of F508del and gating mutants of CFTR.

Veit G, Vaccarin C, Lukacs GL. Veit G, et al. J Cyst Fibros. 2021 Sep;20(5):895-898. doi: 10.1016/j.jcf.2021.03.011. Epub 2021 Mar 26. J Cyst Fibros. 2021. PMID: 33775603 Free PMC article.

19

Discovery of CFTR modulators for the treatment of cystic fibrosis.

Lopes-Pacheco M, Pedemonte N, Veit G. Lopes-Pacheco M, et al. Among authors: veit g. Expert Opin Drug Discov. 2021 Aug;16(8):897-913. doi: 10.1080/17460441.2021.1912732. Epub 2021 Apr 13. Expert Opin Drug Discov. 2021. PMID: 33823716 Review.

20

A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants.

Veit G, Velkov T, Xu H, Vadeboncoeur N, Bilodeau L, Matouk E, Lukacs GL. Veit G, et al. J Pers Med. 2021 Jul 7;11(7):643. doi: 10.3390/jpm11070643. J Pers Med. 2021. PMID: 34357110 Free PMC article.

21

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Soya N, Xu H, Roldan A, Yang Z, Ye H, Jiang F, Premchandar A, Veit G, Cole SPC, Kappes J, Hegedüs T, Lukacs GL. Soya N, et al. Among authors: veit g. Nat Commun. 2023 Oct 27;14(1):6868. doi: 10.1038/s41467-023-42586-8. Nat Commun. 2023. PMID: 37891162 Free PMC article.

22

Editorial: Mechanisms of Novel Drugs and Gene Modifiers in the Treatment of Cystic Fibrosis.

Veit G, Silva I, Conese M, Laselva O. Veit G, et al. Front Mol Biosci. 2022 Jul 12;9:975946. doi: 10.3389/fmolb.2022.975946. eCollection 2022. Front Mol Biosci. 2022. PMID: 35903150 Free PMC article. No abstract available.

23

Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in humans and mice.

Zou Y, Zwolanek D, Izu Y, Gandhy S, Schreiber G, Brockmann K, Devoto M, Tian Z, Hu Y, Veit G, Meier M, Stetefeld J, Hicks D, Straub V, Voermans NC, Birk DE, Barton ER, Koch M, Bönnemann CG. Zou Y, et al. Among authors: veit g. Hum Mol Genet. 2014 May 1;23(9):2339-52. doi: 10.1093/hmg/ddt627. Epub 2013 Dec 11. Hum Mol Genet. 2014. PMID: 24334604 Free PMC article.

24

Type XII collagen regulates osteoblast polarity and communication during bone formation.

Izu Y, Sun M, Zwolanek D, Veit G, Williams V, Cha B, Jepsen KJ, Koch M, Birk DE. Izu Y, et al. Among authors: veit g. J Cell Biol. 2011 Jun 13;193(6):1115-30. doi: 10.1083/jcb.201010010. J Cell Biol. 2011. PMID: 21670218 Free PMC article.

25

Collagen XII interacts with avian tenascin-X through its NC3 domain.

Veit G, Hansen U, Keene DR, Bruckner P, Chiquet-Ehrismann R, Chiquet M, Koch M. Veit G, et al. J Biol Chem. 2006 Sep 15;281(37):27461-70. doi: 10.1074/jbc.M603147200. Epub 2006 Jul 21. J Biol Chem. 2006. PMID: 16861231 Free article.

26

Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment.

Veit G, Zimina EP, Franzke CW, Kutsch S, Siebolds U, Gordon MK, Bruckner-Tuderman L, Koch M. Veit G, et al. J Biol Chem. 2007 Sep 14;282(37):27424-27435. doi: 10.1074/jbc.M703425200. Epub 2007 Jul 11. J Biol Chem. 2007. PMID: 17627939 Free article.

27

Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice.

Egging DF, van Vlijmen-Willems I, Choi J, Peeters AC, van Rens D, Veit G, Koch M, Davis EC, Schalkwijk J. Egging DF, et al. Among authors: veit g. Cell Tissue Res. 2008 Jun;332(3):523-32. doi: 10.1007/s00441-008-0591-y. Epub 2008 Mar 12. Cell Tissue Res. 2008. PMID: 18335242 Free PMC article.

28

Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes.

Bader HL, Keene DR, Charvet B, Veit G, Driever W, Koch M, Ruggiero F. Bader HL, et al. Among authors: veit g. Matrix Biol. 2009 Jan;28(1):32-43. doi: 10.1016/j.matbio.2008.09.580. Epub 2008 Oct 6. Matrix Biol. 2009. PMID: 18983916

29

Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE.

Ansorge HL, Meng X, Zhang G, Veit G, Sun M, Klement JF, Beason DP, Soslowsky LJ, Koch M, Birk DE. Ansorge HL, et al. Among authors: veit g. J Biol Chem. 2009 Mar 27;284(13):8427-38. doi: 10.1074/jbc.M805582200. Epub 2009 Jan 9. J Biol Chem. 2009. PMID: 19136672 Free PMC article.

30

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis.

Veit G, Zwolanek D, Eckes B, Niland S, Käpylä J, Zweers MC, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M. Veit G, et al. J Biol Chem. 2011 Aug 5;286(31):27804-13. doi: 10.1074/jbc.M111.220046. Epub 2011 Jun 7. J Biol Chem. 2011. PMID: 21652699 Free PMC article.

31

Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER.

Zwolanek D, Veit G, Eble JA, Gullberg D, Ruggiero F, Heino J, Meier M, Stetefeld J, Koch M. Zwolanek D, et al. Among authors: veit g. Biochem J. 2014 Apr 1;459(1):217-27. doi: 10.1042/BJ20130642. Biochem J. 2014. PMID: 24428702

32

Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain.

Veit G, Kobbe B, Keene DR, Paulsson M, Koch M, Wagener R. Veit G, et al. J Biol Chem. 2006 Feb 10;281(6):3494-504. doi: 10.1074/jbc.M509333200. Epub 2005 Dec 5. J Biol Chem. 2006. PMID: 16330543 Free article.

33

Expression of type XXIII collagen mRNA and protein.

Koch M, Veit G, Stricker S, Bhatt P, Kutsch S, Zhou P, Reinders E, Hahn RA, Song R, Burgeson RE, Gerecke DR, Mundlos S, Gordon MK. Koch M, et al. Among authors: veit g. J Biol Chem. 2006 Jul 28;281(30):21546-21557. doi: 10.1074/jbc.M604131200. Epub 2006 May 25. J Biol Chem. 2006. PMID: 16728390 Free article.

34

The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting.

Serrano SM, Kim J, Wang D, Dragulev B, Shannon JD, Mann HH, Veit G, Wagener R, Koch M, Fox JW. Serrano SM, et al. Among authors: veit g. J Biol Chem. 2006 Dec 29;281(52):39746-56. doi: 10.1074/jbc.M604855200. Epub 2006 Oct 13. J Biol Chem. 2006. PMID: 17040908 Free article.

35

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

36

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Soya N, Xu H, Roldan A, Yang Z, Ye H, Jiang F, Premchandar A, Veit G, Cole SPC, Kappes J, Hegedus T, Lukacs GL. Soya N, et al. Among authors: veit g. bioRxiv [Preprint]. 2023 Oct 20:2023.10.19.563107. doi: 10.1101/2023.10.19.563107. bioRxiv. 2023. PMID: 37905074 Free PMC article. Updated. Preprint.

37

Blood taken immediately after fatal resuscitation attempts yields higher quality DNA for genetic studies as compared to autopsy samples.

Stanasiuk C, Milting H, Homm S, Persson J, Holtz L, Wittmer A, Fox H, Laser T, Knöll R, Pohl GM, Paluszkiewicz L, Jakob T, Bachmann-Mennenga B, Henzler D, Grautoff S, Veit G, Klingel K, Hori E, Kellner U, Karger B, Schlepper S, Pfeiffer H, Gummert J, Gärtner A, Tiesmeier J. Stanasiuk C, et al. Among authors: veit g. Int J Legal Med. 2023 Sep;137(5):1569-1581. doi: 10.1007/s00414-023-02966-7. Epub 2023 Feb 11. Int J Legal Med. 2023. PMID: 36773088 Free PMC article.

38

Profile of the single-use, multiple-pass protein A adsorber column in immunoadsorption.

Schossee N, Veit G, Gittel J, Viebahn J, Niklaus M, Klingler P, Üçeyler N, Klinker E, Kobsar A, Boeck M, Koessler J. Schossee N, et al. Among authors: veit g. Vox Sang. 2022 Mar;117(3):393-398. doi: 10.1111/vox.13205. Epub 2021 Sep 20. Vox Sang. 2022. PMID: 34545576

39

The emergency medical service has a crucial role to unravel the genetics of sudden cardiac arrest in young, out of hospital resuscitated patients: Interim data from the MAP-IT study.

Tiesmeier J, Gaertner A, Homm S, Jakob T, Stanasiuk C, Bachmann-Mennenga B, Henzler D, Grautoff S, Veit G, Hori E, Kellner U, Gummert JF, Hitz MP, Kostareva A, Klingel K, Paluszkiewicz L, Laser KT, Pfeiffer H, Fox H, Milting H. Tiesmeier J, et al. Among authors: veit g. Resuscitation. 2021 Nov;168:176-185. doi: 10.1016/j.resuscitation.2021.07.042. Epub 2021 Aug 10. Resuscitation. 2021. PMID: 34389451 Free article.

40

An ultrasonic guided wave excitation method at constant phase velocity using ultrasonic phased array probes.

Veit G, Bélanger P. Veit G, et al. Ultrasonics. 2020 Mar;102:106039. doi: 10.1016/j.ultras.2019.106039. Epub 2019 Oct 9. Ultrasonics. 2020. PMID: 31670234

41

Molecular autopsy and family screening in a young case of sudden cardiac death reveals an unusually severe case of FHL1 related hypertrophic cardiomyopathy.

Gaertner-Rommel A, Tiesmeier J, Jakob T, Strickmann B, Veit G, Bachmann-Mennenga B, Paluszkiewicz L, Klingel K, Schulz U, Laser KT, Karger B, Pfeiffer H, Milting H. Gaertner-Rommel A, et al. Among authors: veit g. Mol Genet Genomic Med. 2019 Aug;7(8):e841. doi: 10.1002/mgg3.841. Epub 2019 Jul 10. Mol Genet Genomic Med. 2019. PMID: 31293105 Free PMC article.

42

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL. Veit G, et al. Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935. Mol Biol Cell. 2016. PMID: 26823392 Free PMC article.

43

Treatment of herpes labialis: comparison of two OTC drugs and untreated controls.

McCarthy JP, Browning WD, Teerlink C, Veit G. McCarthy JP, et al. Among authors: veit g. J Esthet Restor Dent. 2012 Apr;24(2):103-9. doi: 10.1111/j.1708-8240.2011.00417.x. Epub 2011 Apr 27. J Esthet Restor Dent. 2012. PMID: 22524716 Free PMC article.

44

Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section.

Bachmann-Mennenga B, Veit G, Steinicke B, Biscoping J, Heesen M. Bachmann-Mennenga B, et al. Among authors: veit g. Acta Anaesthesiol Scand. 2005 Apr;49(4):532-7. doi: 10.1111/j.1399-6576.2005.00657.x. Acta Anaesthesiol Scand. 2005. PMID: 15777302 Clinical Trial.

45

Epidural ropivacaine 1% with and without sufentanil addition for Caesarean section.

Bachmann-Mennenga B, Veit G, Biscoping J, Steinicke B, Heesen M. Bachmann-Mennenga B, et al. Among authors: veit g. Acta Anaesthesiol Scand. 2005 Apr;49(4):525-31. doi: 10.1111/j.1399-6576.2004.00580.x. Acta Anaesthesiol Scand. 2005. PMID: 15777301 Clinical Trial.

46

Influence of basic heart rate and sex on heart rate turbulence in healthy subjects.

Schwab JO, Eichner G, Veit G, Schmitt H, Lewalter T, Lüderitz B. Schwab JO, et al. Among authors: veit g. Pacing Clin Electrophysiol. 2004 Dec;27(12):1625-31. doi: 10.1111/j.1540-8159.2004.00695.x. Pacing Clin Electrophysiol. 2004. PMID: 15613125

47

[Anesthesia techniques for cesarean section--catheter-peridural anesthesia].

Bachmann-Mennenga B, Veit G. Bachmann-Mennenga B, et al. Among authors: veit g. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Jan;36(1):53-7. doi: 10.1055/s-2001-10239-7. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001. PMID: 11227313 Review. German. No abstract available.

48

[Mr 1268--a new furylmethyl-substituted benzomorphan. Comparison of its effects with pentazocine and placebo in a double-blind study].

Behrendt W, Conrad H, Richter M, Veit G. Behrendt W, et al. Among authors: veit g. Anaesthesist. 1983 Jul;32(7):340-4. Anaesthesist. 1983. PMID: 6351663 Clinical Trial. German.

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