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Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathology.
Clin Transl Med. 2021 Feb;11(2):e336. doi: 10.1002/ctm2.336.
Clin Transl Med. 2021.
PMID: 33634973
Free PMC article.
Incorporating upper motor neuron health in ALS drug discovery.
Dervishi I, Ozdinler PH.
Dervishi I, et al.
Drug Discov Today. 2018 Mar;23(3):696-703. doi: 10.1016/j.drudis.2018.01.027. Epub 2018 Jan 10.
Drug Discov Today. 2018.
PMID: 29331501
Free PMC article.
Review.
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Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS.
Dervishi I, Gozutok O, Murnan K, Gautam M, Heller D, Bigio E, Ozdinler PH.
Dervishi I, et al.
Sci Rep. 2018 Oct 3;8(1):14732. doi: 10.1038/s41598-018-32902-4.
Sci Rep. 2018.
PMID: 30283000
Free PMC article.
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