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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 21
1947 23
1948 27
1949 31
1950 36
1951 47
1952 37
1953 27
1954 28
1955 23
1956 42
1957 31
1958 36
1959 31
1960 39
1961 39
1962 40
1963 78
1964 118
1965 154
1966 310
1967 377
1968 397
1969 354
1970 421
1971 353
1972 399
1973 493
1974 602
1975 673
1976 708
1977 879
1978 1687
1979 1946
1980 16810
1981 35160
1982 36318
1983 36926
1984 38477
1985 39389
1986 40506
1987 41890
1988 43186
1989 44926
1990 47280
1991 49074
1992 49574
1993 50122
1994 51597
1995 52306
1996 52590
1997 53175
1998 54710
1999 55997
2000 58246
2001 59733
2002 62908
2003 67525
2004 75219
2005 82143
2006 91223
2007 97842
2008 108140
2009 114449
2010 123994
2011 133550
2012 138574
2013 144105
2014 146170
2015 147301
2016 141852
2017 136390
2018 138709
2019 139285
2020 152012
2021 158550
2022 143349
2023 137524
2024 47104
2025 1

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The following term was not found in PubMed: 5K99HL155845
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The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease.
Wang HP, Scalco R, Saito N, Beckett L, Nguyen ML, Huie EZ, Honig LS, DeCarli C, Rissman RA, Teich AF, Mungas DM, Jin LW, Dugger BN. Wang HP, et al. Acta Neuropathol Commun. 2024 May 24;12(1):81. doi: 10.1186/s40478-024-01773-4. Acta Neuropathol Commun. 2024. PMID: 38790074
The study included cases with a pathological diagnosis of Intermediate/High AD based on the National Institute on Aging- Alzheimer's Association (NIA-AA) and/or NIA-Reagan criteria. ...
The study included cases with a pathological diagnosis of Intermediate/High AD based on the National Institute on Aging- Alzheimer's …
Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms.
Courchesne E, Taluja V, Nazari S, Aamodt CM, Pierce K, Duan K, Stophaeros S, Lopez L, Barnes CC, Troxel J, Campbell K, Wang T, Hoekzema K, Eichler EE, Nani JV, Pontes W, Sanchez SS, Lombardo MV, de Souza JS, Hayashi MAF, Muotri AR. Courchesne E, et al. Mol Autism. 2024 May 25;15(1):22. doi: 10.1186/s13229-024-00602-8. Mol Autism. 2024. PMID: 38790065
Longitudinal Change in Appearance-Related Social Media Consciousness and Depressive Symptoms: A Within-Person Analysis during Early-to-Middle Adolescence.
Maheux AJ, Laurenceau JP, Roberts SR, Nesi J, Widman L, Choukas-Bradley S. Maheux AJ, et al. J Youth Adolesc. 2024 May 24. doi: 10.1007/s10964-024-01998-5. Online ahead of print. J Youth Adolesc. 2024. PMID: 38789876
Online appearance preoccupation may put adolescents at risk of developing mental health challenges, perhaps especially during early-to-middle adolescence. A random intercept cross-lagged panel model assessed within-person associations between appearance-related social medi …
Online appearance preoccupation may put adolescents at risk of developing mental health challenges, perhaps especially during early-t …
Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment.
Bharadiya V, Rong Y, Zhang Z, Lin R, Guerrerio AL, Tse CM, Donowitz M, Singh V. Bharadiya V, et al. Sci Rep. 2024 May 24;14(1):11911. doi: 10.1038/s41598-024-62282-x. Sci Rep. 2024. PMID: 38789719
Lack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap in the management of these patients. Human enteroids have emerged as a ph …
Lack of understanding of the pathophysiology of gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal t …
Structural insights into PPP2R5A degradation by HIV-1 Vif.
Hu Y, Delviks-Frankenberry KA, Wu C, Arizaga F, Pathak VK, Xiong Y. Hu Y, et al. Nat Struct Mol Biol. 2024 May 24. doi: 10.1038/s41594-024-01314-6. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38789685
Mechanisms of neuromodulatory volume transmission.
Özçete ÖD, Banerjee A, Kaeser PS. Özçete ÖD, et al. Mol Psychiatry. 2024 May 24. doi: 10.1038/s41380-024-02608-3. Online ahead of print. Mol Psychiatry. 2024. PMID: 38789677 Review.
This mechanistic knowledge is essential to define how neuromodulatory systems control behavior in health and disease and to understand how they are modulated by medical treatments and by drugs of abuse....
This mechanistic knowledge is essential to define how neuromodulatory systems control behavior in health and disease and to understan …
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer.
Patterson MR, Meijers AS, Ryder EL, Wootton LM, Scarth JA, Evans D, Turner AL, Wasson CW, Darell JE, Theobald DA, Cogan JA, James CD, Wang M, Ladbury JE, Morgan IM, Samson A, Morgan EL, Macdonald A. Patterson MR, et al. Oncogene. 2024 May 24. doi: 10.1038/s41388-024-03067-4. Online ahead of print. Oncogene. 2024. PMID: 38789663
Human papillomaviruses (HPV) are a major cause of malignancy, contributing to ~5% of all human cancers worldwide, including most cervical cancer cases and a growing number of anogenital and oral cancers. ...
Human papillomaviruses (HPV) are a major cause of malignancy, contributing to ~5% of all human cancers worldwide, including mo
Isradipine augmentation of virtual reality cue exposure therapy for tobacco craving: a triple-blind randomized controlled trial.
Young CC, Papini S, Minami H, Morikawa H, Otto MW, Roache JD, Smits JAJ. Young CC, et al. Neuropsychopharmacology. 2024 May 24. doi: 10.1038/s41386-024-01872-9. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 38789642
Although isradipine alone, which is FDA-approved for hypertension, has not shown a direct effect on craving in human drug users, its potential to augment behavioral treatments designed to reduce craving remains unknown. ...
Although isradipine alone, which is FDA-approved for hypertension, has not shown a direct effect on craving in human drug users, its …
A neural pathway integrating stress and feeding.
Butts J, Sweeney P. Butts J, et al. Neuropsychopharmacology. 2024 May 24. doi: 10.1038/s41386-024-01890-7. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 38789641 No abstract available.
Adjuvant Chemotherapy With or Without Radiotherapy for Resected Pancreatic Cancer After Multiagent Neoadjuvant Chemotherapy.
Franklin O, Sugawara T, Ross RB, Rodriguez Franco S, Colborn K, Karam S, Schulick RD, Del Chiaro M. Franklin O, et al. Ann Surg Oncol. 2024 May 24. doi: 10.1245/s10434-024-15157-4. Online ahead of print. Ann Surg Oncol. 2024. PMID: 38789615
However, whether adjuvant treatment should include radiotherapy is unclear in this setting. METHODS: This study queried the National Cancer Database for pancreatic adenocarcinoma patients who underwent curative resection after multiagent neoadjuvant chemotherapy between 20 …
However, whether adjuvant treatment should include radiotherapy is unclear in this setting. METHODS: This study queried the National
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero.
Fajardo-Martinez V, Ferreira F, Fuller T, Cambou MC, Kerin T, Paiola S, Mok T, Rao R, Mohole J, Paravastu R, Zhang D, Marschik P, Iyer S, Kesavan K, Borges Lopes MDC, Britto JAA, Moreira ME, Brasil P, Nielsen-Saines K. Fajardo-Martinez V, et al. Sci Rep. 2024 May 24;14(1):11851. doi: 10.1038/s41598-024-61918-2. Sci Rep. 2024. PMID: 38789553
Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis.
Tan C, Reilly B, Ma G, Murao A, Jha A, Aziz M, Wang P. Tan C, et al. Cell Mol Immunol. 2024 May 24. doi: 10.1038/s41423-024-01165-7. Online ahead of print. Cell Mol Immunol. 2024. PMID: 38789529
Neutrophils aid B-1a cell migration via neutrophil elastase (NE)-mediated Siglec-G cleavage. Human studies revealed increased NE expression in septic patients. ...
Neutrophils aid B-1a cell migration via neutrophil elastase (NE)-mediated Siglec-G cleavage. Human studies revealed increased NE expr …
Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis.
Ebrahimi B, Viswanadhapalli S, Pratap UP, Rahul G, Yang X, Pitta Venkata P, Drel V, Santhamma B, Konda S, Li X, Sanchez ALR, Yan H, Sareddy GR, Xu Z, Singh BB, Valente PT, Chen Y, Lai Z, Rao M, Kost ER, Curiel T, Tekmal RR, Nair HB, Vadlamudi RK. Ebrahimi B, et al. NPJ Precis Oncol. 2024 May 24;8(1):118. doi: 10.1038/s41698-024-00612-y. NPJ Precis Oncol. 2024. PMID: 38789520
Choosing a camera and optimizing system parameters for speckle contrast optical spectroscopy.
Cheng TY, Kim B, Zimmermann BB, Robinson MB, Renna M, Carp SA, Franceschini MA, Boas DA, Cheng X. Cheng TY, et al. Sci Rep. 2024 May 24;14(1):11915. doi: 10.1038/s41598-024-62106-y. Sci Rep. 2024. PMID: 38789499
Speckle contrast optical spectroscopy (SCOS) is an emerging camera-based technique that can measure human cerebral blood flow (CBF) with high signal-to-noise ratio (SNR). At low photon flux levels typically encountered in human CBF measurements, camera noise and non …
Speckle contrast optical spectroscopy (SCOS) is an emerging camera-based technique that can measure human cerebral blood flow (CBF) w …
Relative dispersion ratios following fecal microbiota transplant elucidate principles governing microbial migration dynamics.
Algavi YM, Borenstein E. Algavi YM, et al. Nat Commun. 2024 May 24;15(1):4447. doi: 10.1038/s41467-024-48717-z. Nat Commun. 2024. PMID: 38789466
Moreover, while theoretical models and in-vitro experiments have highlighted the contribution of species interactions to community assembly, identifying such interactions in vivo, specifically in communities as complex as the human gut, remains challenging. To address this …
Moreover, while theoretical models and in-vitro experiments have highlighted the contribution of species interactions to community assembly, …
Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer.
Beckabir W, Zhou M, Lee JS, Vensko SP, Woodcock MG, Wang HH, Wobker SE, Atassi G, Wilkinson AD, Fowler K, Flick LM, Damrauer JS, Harrison MR, McKinnon KP, Rose TL, Milowsky MI, Serody JS, Kim WY, Vincent BG. Beckabir W, et al. Nat Commun. 2024 May 24;15(1):4448. doi: 10.1038/s41467-024-48480-1. Nat Commun. 2024. PMID: 38789460 Clinical Trial.
BOLD: Blood-gas and Oximetry Linked Dataset.
Matos J, Struja T, Gallifant J, Nakayama L, Charpignon ML, Liu X, Economou-Zavlanos N, S Cardoso J, Johnson KS, Bhavsar N, Gichoya J, Celi LA, Wong AI. Matos J, et al. Sci Data. 2024 May 24;11(1):535. doi: 10.1038/s41597-024-03225-z. Sci Data. 2024. PMID: 38789452
BOLD is a dataset that aims to underscore the importance of addressing biases in pulse oximetry accuracy, which disproportionately affect darker-skinned patients. The dataset was created by harmonizing three Electronic Health Record databases (MIMIC-III, MIMIC-IV, eICU-CRD …
BOLD is a dataset that aims to underscore the importance of addressing biases in pulse oximetry accuracy, which disproportionately affect da …
Profiling complex repeat expansions in RFC1 in Parkinson's disease.
Alvarez Jerez P, Daida K, Miano-Burkhardt A, Iwaki H, Malik L, Cogan G, Makarious MB, Sullivan R, Vandrovcova J, Ding J, Gibbs JR, Markham A, Nalls MA, Kesharwani RK, Sedlazeck FJ, Casey B, Hardy J, Houlden H, Blauwendraat C, Singleton AB, Billingsley KJ. Alvarez Jerez P, et al. NPJ Parkinsons Dis. 2024 May 24;10(1):108. doi: 10.1038/s41531-024-00723-0. NPJ Parkinsons Dis. 2024. PMID: 38789445
Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies.
Wu MH, Valenca-Pereira F, Cendali F, Giddings EL, Pham-Danis C, Yarnell MC, Novak AJ, Brunetti TM, Thompson SB, Henao-Mejia J, Flavell RA, D'Alessandro A, Kohler ME, Rincon M. Wu MH, et al. Nat Commun. 2024 May 24;15(1):4444. doi: 10.1038/s41467-024-48653-y. Nat Commun. 2024. PMID: 38789421
Furthermore, we show for the first time that MCJ is expressed in human CD8 cells and that the level of MCJ expression correlates with the functional activity of CD8(+) CAR-T cells. Silencing MCJ expression in human CD8 CAR-T cells increases their mitochondrial metab …
Furthermore, we show for the first time that MCJ is expressed in human CD8 cells and that the level of MCJ expression correlates with …
Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.
Keener R, Chhetri SB, Connelly CJ, Taub MA, Conomos MP, Weinstock J, Ni B, Strober B, Aslibekyan S, Auer PL, Barwick L, Becker LC, Blangero J, Bleecker ER, Brody JA, Cade BE, Celedon JC, Chang YC, Cupples LA, Custer B, Freedman BI, Gladwin MT, Heckbert SR, Hou L, Irvin MR, Isasi CR, Johnsen JM, Kenny EE, Kooperberg C, Minster RL, Naseri T, Viali S, Nekhai S, Pankratz N, Peyser PA, Taylor KD, Telen MJ, Wu B, Yanek LR, Yang IV, Albert C, Arnett DK, Ashley-Koch AE, Barnes KC, Bis JC, Blackwell TW, Boerwinkle E, Burchard EG, Carson AP, Chen Z, Chen YI, Darbar D, de Andrade M, Ellinor PT, Fornage M, Gelb BD, Gilliland FD, He J, Islam T, Kaab S, Kardia SLR, Kelly S, Konkle BA, Kumar R, Loos RJF, Martinez FD, McGarvey ST, Meyers DA, Mitchell BD, Montgomery CG, North KE, Palmer ND, Peralta JM, Raby BA, Redline S, Rich SS, Roden D, Rotter JI, Ruczinski I, Schwartz D, Sciurba F, Shoemaker MB, Silverman EK, Sinner MF, Smith NL, Smith AV, Tiwari HK, Vasan RS, Weiss ST, Williams LK, Zhang Y, Ziv E, Raffield LM, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology and Hemostasis Working Group; TOPMed Structural Variation Working Group; Arvanitis M, Greider … See abstract for full author list ➔ Keener R, et al. Nat Commun. 2024 May 24;15(1):4417. doi: 10.1038/s41467-024-48394-y. Nat Commun. 2024. PMID: 38789417
Navigating the mammography quality standard act in USA: Role of US FDA and future scopes of regulation.
Bhumika NM, Mishra S, Arjun M, Venkatesh MP. Bhumika NM, et al. J Med Imaging Radiat Sci. 2024 May 23:101420. doi: 10.1016/j.jmir.2024.04.013. Online ahead of print. J Med Imaging Radiat Sci. 2024. PMID: 38789291 Review.
BACKGROUND: The Mammography Quality Standards Act (MQSA) has significant impact on providing high-quality mammography services for the early detection of breast cancer. MQSA emphasizes quality assurance, regulatory compliance, and patient safety. It guides technological in …
BACKGROUND: The Mammography Quality Standards Act (MQSA) has significant impact on providing high-quality mammography services for th …
Proximal femoral varus osteotomy for Legg-Calvé-Perthes disease: do age and lateral pillar classifications influence short-to-mid-term clinical and radiological outcomes?
Zare NH, Mirghaderi P, Ilharreborde B, Geraylow KR, Moharrami A, Baghdadi T, Kalantar SH, Nabian MH. Zare NH, et al. Orthop Traumatol Surg Res. 2024 May 22:103909. doi: 10.1016/j.otsr.2024.103909. Online ahead of print. Orthop Traumatol Surg Res. 2024. PMID: 38789002
We evaluated radiological (center-edge angle, extrusion index, epiphyseal index, acetabular index, articulo-trochanteric distance (ATD)) and clinical (hip abduction range of motion (ROM), Trendelenburg sign, pain, and Harris hip score (HHS)) outcomes with a follow-up of 37 …
We evaluated radiological (center-edge angle, extrusion index, epiphyseal index, acetabular index, articulo-trochanteric distance (ATD)) and …
The LAT rheostat as a regulator of megakaryocyte activation.
Moroi AJ, Newman PJ. Moroi AJ, et al. Thromb Haemost. 2024 May 24. doi: 10.1055/a-2332-6321. Online ahead of print. Thromb Haemost. 2024. PMID: 38788774
METHODS: To examine whether LAT Gly131 restricts ITAM signaling in cells of the megakaryocyte lineage, we introduced an aspartic acid at this position in human iPS cells, differentiated them into megakaryocytes, and examined its functional consequences. ...
METHODS: To examine whether LAT Gly131 restricts ITAM signaling in cells of the megakaryocyte lineage, we introduced an aspartic acid at thi …
Dolutegravir plus boosted darunavir versus recommended standard-of-care antiretroviral regimens in people with HIV-1 for whom recommended first-line non-nucleoside reverse transcriptase inhibitor therapy has failed (D2EFT): an open-label, randomised, phase 3b/4 trial.
D2EFT Study Group. D2EFT Study Group. Lancet HIV. 2024 May 21:S2352-3018(24)00089-4. doi: 10.1016/S2352-3018(24)00089-4. Online ahead of print. Lancet HIV. 2024. PMID: 38788744
These global data support the most recent WHO treatment guidelines. FUNDING: UNITAID; National Institute of Allergy and Infectious Diseases, USA; National Health and Medical Research Council, Australia; ViiV Healthcare; and Janssen....
These global data support the most recent WHO treatment guidelines. FUNDING: UNITAID; National Institute of Allergy and Infectious Di …
Optimal management of radiation pneumonitis: Findings of an international Delphi consensus study.
Voruganti Maddali IS, Cunningham C, McLeod L, Bahig H, Chaudhuri N, L M Chua K, Evison M, Faivre-Finn C, Franks K, Harden S, Videtic G, Lee P, Senan S, Siva S, Palma DA, Phillips I, Kruser J, Kruser T, Peedell C, Melody Qu X, Robinson C, Wright A, Harrow S, Louie AV. Voruganti Maddali IS, et al. Lung Cancer. 2024 May 14;192:107822. doi: 10.1016/j.lungcan.2024.107822. Online ahead of print. Lung Cancer. 2024. PMID: 38788551
Horizontal and vertical equity and public subsidies for private health insurance in the U.S.
Jacobs PD, Hill SC. Jacobs PD, et al. Soc Sci Med. 2024 May 18;351:116994. doi: 10.1016/j.socscimed.2024.116994. Online ahead of print. Soc Sci Med. 2024. PMID: 38788429
The United States offers two markedly different subsidy structures for private health insurance. ...While Marketplace subsidies have clearly improved equity within the United States, we conclude with a comparison to other OECD countries highligh …
The United States offers two markedly different subsidy structures for private health insurance. ...While Marketplace s …
Ensuring accountability for consideration of sex as a biological variable in research.
Kostas-Polston EA, Bevans M, Shea TL, McGlothen-Bell K, Nies MA, Alexander IM, Johnson-Mallard V, Clayton JA. Kostas-Polston EA, et al. Nurs Outlook. 2024 May 22;72(4):102194. doi: 10.1016/j.outlook.2024.102194. Online ahead of print. Nurs Outlook. 2024. PMID: 38788270
The National Institute of Health (NIH) policy, Consideration of Sex as a Biological Variable (SABV) in NIH-funded Research (2015), focuses on the expectation that researchers account for the influence of SABV in vertebrate animal and human studi …
The National Institute of Health (NIH) policy, Consideration of Sex as a Biological Variable (SABV) in NIH-funde …
Federal and foundational research funding trends for cerebrovascular neurosurgeons: the decline of the cerebrovascular surgeon-scientist?
Pugazenthi S, Srienc AI, Cantu L, Huguenard AL, Eskandar E, Mack WJ, Amin-Hanjani S, Vellimana AK, Osbun JW, Zipfel GJ. Pugazenthi S, et al. J Neurosurg. 2024 May 24:1-10. doi: 10.3171/2024.2.JNS232287. Online ahead of print. J Neurosurg. 2024. PMID: 38788229
With increasing numbers of CV neurosurgeons in the US workforce, the authors analyzed associated changes in National Institutes of Health (NIH) and Neurosurgery Research and Education Foundation (NREF) funding trends for CV surgeons over time. ...Addit …
With increasing numbers of CV neurosurgeons in the US workforce, the authors analyzed associated changes in National Institutes
Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis.
Borrelli S, Martire MS, Stölting A, Vanden Bulcke C, Pedrini E, Guisset F, Bugli C, Yildiz H, Pothen L, Elands S, Martinelli V, Smith B, Jacobson S, Du Pasquier RA, Van Pesch V, Filippi M, Reich DS, Absinta M, Maggi P. Borrelli S, et al. Neurol Neuroimmunol Neuroinflamm. 2024 Jul;11(4):e200253. doi: 10.1212/NXI.0000000000200253. Epub 2024 May 24. Neurol Neuroimmunol Neuroinflamm. 2024. PMID: 38788180
Knowledge-guided generative artificial intelligence for automated taxonomy learning from drug labels.
Fang Y, Ryan P, Weng C. Fang Y, et al. J Am Med Inform Assoc. 2024 May 24:ocae105. doi: 10.1093/jamia/ocae105. Online ahead of print. J Am Med Inform Assoc. 2024. PMID: 38787964
We show that LLMs are good at deriving their own concept hierarchies but still fall short in determining the subsumption relations between concepts and terms in unregulated language from free-text drug labels, which is the same hard task for human experts....
We show that LLMs are good at deriving their own concept hierarchies but still fall short in determining the subsumption relations between c …
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG. Abbott KL, et al. Elife. 2024 May 24;13:RP95652. doi: 10.7554/eLife.95652. Elife. 2024. PMID: 38787918 Free PMC article.
Association between physical measures of spinopelvic alignment and physical functioning with patient reported outcome measures (PROMs) after total hip arthroplasty: Protocol for systematic review and meta-analysis.
Vatandoost S, Kowalski K, Lanting B, Ng KCG, Soltanabadi S, Rushton A. Vatandoost S, et al. PLoS One. 2024 May 24;19(5):e0304382. doi: 10.1371/journal.pone.0304382. eCollection 2024. PLoS One. 2024. PMID: 38787884
Two independent reviewers will evaluate eligibility of retrieved articles, extract data and assess risk of bias (NIH quality assessment tool) of included studies. A third reviewer will mediate disagreements. ...
Two independent reviewers will evaluate eligibility of retrieved articles, extract data and assess risk of bias (NIH quality assessme …
The Hill function is the universal Hopfield barrier for sharpness of input-output responses.
Martinez-Corral R, Nam KM, DePace AH, Gunawardena J. Martinez-Corral R, et al. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2318329121. doi: 10.1073/pnas.2318329121. Epub 2024 May 24. Proc Natl Acad Sci U S A. 2024. PMID: 38787881
Models may represent arbitrary molecular complexity, with multiple ligands, internal states, conformations, coregulators, etc, under core assumptions that are detailed in the paper. ...
Models may represent arbitrary molecular complexity, with multiple ligands, internal states, conformations, coregulators, etc, under …
Clinical evaluation of platelet-rich plasma therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis.
Guo G, Ouyang W, Wang G, Zhao W, Zhao C. Guo G, et al. PLoS One. 2024 May 24;19(5):e0304096. doi: 10.1371/journal.pone.0304096. eCollection 2024. PLoS One. 2024. PMID: 38787864
METHODS: We comprehensively searched randomized controlled trials in PubMed, Web of Science, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, WanFang, and Chinese BioMedica …
METHODS: We comprehensively searched randomized controlled trials in PubMed, Web of Science, EMBASE, the Cochrane Central Register of Contro …
Radiation-induced gastrointestinal and cutaneous injuries: understanding models, pathologies, assessments, and clinically accepted practices.
Tamarat R, Satyamitra MM, Benderitter M, DiCarlo AL. Tamarat R, et al. Int J Radiat Biol. 2024 May 24:1-13. doi: 10.1080/09553002.2024.2356544. Online ahead of print. Int J Radiat Biol. 2024. PMID: 38787685
PURPOSE: A U. S. and European joint effort fostering the development of medical countermeasures (MCMs) operable in case of radiological or nuclear emergencies. METHODS: Based on the joint engagement between the U.S. National Institute of Allergy …
PURPOSE: A U. S. and European joint effort fostering the development of medical countermeasures (MCMs) operable in case of rad …
Invasive electrochemical impedance spectroscopy with phase delay for experimental atherosclerosis phenotyping.
Chen M, Neverova N, Xu S, Suwannaphoom K, Lluri G, Tamboline M, Duarte S, Fishbein MC, Luo Y, Packard RRS. Chen M, et al. FASEB J. 2024 May 31;38(10):e23700. doi: 10.1096/fj.202302544RR. FASEB J. 2024. PMID: 38787606
These findings indicate the potential of invasive EIS to comprehensively evaluate human coronary artery disease....
These findings indicate the potential of invasive EIS to comprehensively evaluate human coronary artery disease....
Trust and 2024 Public Priorities for the CDC and State Health Departments.
SteelFisher GK, Findling MG, Caporello HL, Boyea A, Espino L, Sutton J. SteelFisher GK, et al. JAMA Health Forum. 2024 May 3;5(5):e240862. doi: 10.1001/jamahealthforum.2024.0862. JAMA Health Forum. 2024. PMID: 38787541
This survey study evaluates public health priorities and trust in the Centers for Disease Control and Prevention (CDC) and state health departments among US adults after the COVID-19 pandemic....
This survey study evaluates public health priorities and trust in the Centers for Disease Control and Prevention (CDC) and state h
Fmo induction as a tool to screen for pro-longevity drugs.
Huang S, Cox RL, Tuckowski A, Beydoun S, Bhat A, Howington MB, Sarker M, Miller H, Ruwe E, Wang E, Li X, Gardea EA, DeNicola D, Peterson W, Carrier JM, Miller RA, Sutphin GL, Leiser SF. Huang S, et al. Geroscience. 2024 May 24. doi: 10.1007/s11357-024-01207-y. Online ahead of print. Geroscience. 2024. PMID: 38787463
This makes them an attractive potential target of small molecule drugs to stimulate the health-promoting effects of longevity pathways. Here, we utilize an fmo-2 fluorescent transcriptional reporter in C. elegans to screen a set of 80 compounds previously shown to improve …
This makes them an attractive potential target of small molecule drugs to stimulate the health-promoting effects of longevity pathway …
Risk of Neonatal Hypoglycemia in Infants of Mothers With Gestational Glucose Intolerance.
Andrews C, Maya J, Schulte CCM, Hsu S, Thaweethai T, James KE, Halperin J, Powe CE, Sen S. Andrews C, et al. Diabetes Care. 2024 May 24:dc232239. doi: 10.2337/dc23-2239. Online ahead of print. Diabetes Care. 2024. PMID: 38787410
Future research should include examination of these associations in a cohort with more complete neonatal blood glucose ascertainment and determination of the clinical significance of these findings on long-term child health....
Future research should include examination of these associations in a cohort with more complete neonatal blood glucose ascertainment and det …
Non-Invasive Assessment of Human Microvascular Function in Health and Disease using Incident Dark Field Microscopy.
Katunaric B, SenthilKumar G, Stehula F, Werthman A, Bordas-Murphy H, Freed JK. Katunaric B, et al. Am J Physiol Heart Circ Physiol. 2024 May 24. doi: 10.1152/ajpheart.00292.2024. Online ahead of print. Am J Physiol Heart Circ Physiol. 2024. PMID: 38787388
These results suggest that despite baseline reductions in both microvascular density and perfusion, human in vivo peripheral microvascular reactivity to both endothelial-dependent and -independent vasoactive agents remains intact in individuals with CAD or multiple risk fa …
These results suggest that despite baseline reductions in both microvascular density and perfusion, human in vivo peripheral microvas …
A systematic review and meta-analysis of Murray's Law in the Coronary Arterial Circulation.
Taylor DJ, Saxton H, Halliday I, Newman T, Hose DR, Kassab GS, Gunn JP, Morris PD. Taylor DJ, et al. Am J Physiol Heart Circ Physiol. 2024 May 24. doi: 10.1152/ajpheart.00142.2024. Online ahead of print. Am J Physiol Heart Circ Physiol. 2024. PMID: 38787386
A random-effects meta-analysis was used to determine a pooled flow-diameter exponent. Risk of bias was assessed with the National Institutes of Health (NIH) quality assessment tool, funnel plots and Egger regression. ...This exponent may provide a more …
A random-effects meta-analysis was used to determine a pooled flow-diameter exponent. Risk of bias was assessed with the National
Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.
Yan D, Hu B, Darst BF, Mukherjee S, Kunkle BW, Deming Y, Dumitrescu L, Wang Y, Naj A, Kuzma A, Zhao Y, Kang H, Johnson SC, Carlos C, Hohman TJ, Crane PK, Engelman CD; Alzheimer’s Disease Genetics Consortium (ADGC); Lu Q. Yan D, et al. Elife. 2024 May 24;12:RP91360. doi: 10.7554/eLife.91360. Elife. 2024. PMID: 38787369 Free PMC article.
Rich data from large biobanks, coupled with increasingly accessible association statistics from genome-wide association studies (GWAS), provide great opportunities to dissect the complex relationships among human traits and diseases. We introduce BADGERS, a powerful method …
Rich data from large biobanks, coupled with increasingly accessible association statistics from genome-wide association studies (GWAS), prov …
Prediction of Readmission Following Sepsis Using Social Determinants of Health.
Amrollahi F, Kennis BD, Shashikumar SP, Malhotra A, Taylor SP, Ford J, Rodriguez A, Weston J, Maheshwary R, Nemati S, Wardi G, Meier A. Amrollahi F, et al. Crit Care Explor. 2024 May 24;6(6):e1099. doi: 10.1097/CCE.0000000000001099. eCollection 2024 Jun 1. Crit Care Explor. 2024. PMID: 38787299
DESIGN: Multicenter retrospective cohort study using patient-level data, including demographic, clinical, and survey data. SETTINGS: Thirty-five hospitals across the United States from 2017 to 2021. PATIENTS: Two hundred seventy-one thousand four hundred twenty-eigh …
DESIGN: Multicenter retrospective cohort study using patient-level data, including demographic, clinical, and survey data. SETTINGS: Thirty- …
Role of Type 4B Secretion System Protein, IcmE, in the Pathogenesis of Coxiella burnetii.
Palanisamy R, Zhang Y, Zhang G. Palanisamy R, et al. Pathogens. 2024 May 14;13(5):405. doi: 10.3390/pathogens13050405. Pathogens. 2024. PMID: 38787259 Free PMC article.
Additionally, Tn::icmE mutant bacteria were unable to replicate in mouse bone marrow-derived macrophages (MBMDM) and human macrophage-like cells (THP-1). Immunoblotting results showed that the Tn::icmE mutant failed to activate inflammasome components such as IL-1beta, cas …
Additionally, Tn::icmE mutant bacteria were unable to replicate in mouse bone marrow-derived macrophages (MBMDM) and human macrophage …
The Role of Prevotella Species in Female Genital Tract Infections.
George SD, Van Gerwen OT, Dong C, Sousa LGV, Cerca N, Elnaggar JH, Taylor CM, Muzny CA. George SD, et al. Pathogens. 2024 Apr 28;13(5):364. doi: 10.3390/pathogens13050364. Pathogens. 2024. PMID: 38787215 Free PMC article. Review.
They commonly occur in women of reproductive age and are strongly associated with multiple adverse health outcomes including increased risk of HIV/sexually transmitted infection acquisition and transmission, infertility, and adverse birth outcomes such as preterm birth. .. …
They commonly occur in women of reproductive age and are strongly associated with multiple adverse health outcomes including increase …
Perinatal Tetrahydrocannabinol Compromises Maternal Care and Increases Litter Attrition in the Long-Evans Rat.
Carlson E, Teboul E, Canale C, Coleman H, Angeliu C, Garbarini K, Markowski VP. Carlson E, et al. Toxics. 2024 Apr 26;12(5):311. doi: 10.3390/toxics12050311. Toxics. 2024. PMID: 38787090 Free PMC article.
The marijuana legalization trend in the U.S. will likely lead to increased use by younger adults during gestation and postpartum. ...The current findings indicate that maternal care is an important and heretofore overlooked index of THC behavioral toxicity and shoul …
The marijuana legalization trend in the U.S. will likely lead to increased use by younger adults during gestation and postpart …
Mass Spectrometric Analysis of Purine Intermediary Metabolism Indicates Cyanide Induces Purine Catabolism in Rabbits.
Morningstar J, Lee J, Mahon S, Brenner M, Nath AK. Morningstar J, et al. Metabolites. 2024 May 10;14(5):279. doi: 10.3390/metabo14050279. Metabolites. 2024. PMID: 38786756 Free PMC article.
When purine levels increase, excess purines are either recycled to synthesize purine metabolites or catabolized to the end product uric acid. Purine catabolism increases during states of low oxygen tension (hypoxia and ischemia), but this metabolic pathway is incompletely …
When purine levels increase, excess purines are either recycled to synthesize purine metabolites or catabolized to the end product uric acid …
A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation.
Lovrić M, Wang T, Staffe MR, Šunić I, Časni K, Lasky-Su J, Chawes B, Rasmussen MA. Lovrić M, et al. Metabolites. 2024 May 10;14(5):278. doi: 10.3390/metabo14050278. Metabolites. 2024. PMID: 38786755 Free PMC article.
The metabolites measured in the children's serums are predicted to affect specific targeted models, known for their significance in inflammation, immune function, and health outcomes. The targets from Tox21 have been used as targets with quantitative structure-activity rel …
The metabolites measured in the children's serums are predicted to affect specific targeted models, known for their significance in inflamma …
Intake Biomarkers for Nutrition and Health: Review and Discussion of Methodology Issues.
Prentice RL. Prentice RL. Metabolites. 2024 May 10;14(5):276. doi: 10.3390/metabo14050276. Metabolites. 2024. PMID: 38786753 Free PMC article. Review.
My comments here will derive primarily from our research group's recent contributions to the Women's Health Initiative cohorts. I will complete the contribution by describing some opportunities to build on the collective 20 years of effort, including opportunities related …
My comments here will derive primarily from our research group's recent contributions to the Women's Health Initiative cohorts. I wil …
Diabetes Causes Significant Alterations in Pulmonary Glucose Transporter Expression.
Campolo A, Maria Z, Lacombe VA. Campolo A, et al. Metabolites. 2024 May 7;14(5):267. doi: 10.3390/metabo14050267. Metabolites. 2024. PMID: 38786744 Free PMC article.
Specifically, the protein expression of the predominant glucose transporter (GLUT) isoforms in the adult lung remains largely to be characterized in both healthy and diabetic states. Type 1 diabetes was induced via streptozotocin and rescued via subcutaneous semi-osmotic i …
Specifically, the protein expression of the predominant glucose transporter (GLUT) isoforms in the adult lung remains largely to be characte …
Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma.
Bansal S, Li Y, Bansal S, Klotzbier W, Singh B, Jayatilake M, Sridharan V, Fernández JA, Griffin JH, Weiler H, Boerma M, Cheema AK. Bansal S, et al. Metabolites. 2024 Apr 24;14(5):245. doi: 10.3390/metabo14050245. Metabolites. 2024. PMID: 38786722 Free PMC article.
The APCHi mouse model used in the study was developed in a C57BL/6N background, expressing the D168F/N173K mouse analog of the hyper-activatable human D167F/D172K protein C variant. This modification enables increased circulating APC levels throughout the mouse's lifetime. …
The APCHi mouse model used in the study was developed in a C57BL/6N background, expressing the D168F/N173K mouse analog of the hyper-activat …
Impact of Nitric Oxide-Release Kinetics on Antifungal Activity.
Grayton QE, Conlon IL, Broberg CA, Schoenfisch MH. Grayton QE, et al. J Fungi (Basel). 2024 Apr 24;10(5):308. doi: 10.3390/jof10050308. J Fungi (Basel). 2024. PMID: 38786663 Free PMC article.
Pathogenic fungi are an increasing health threat due to the rise in drug resistance. The limited number of antifungals currently available and growing incidence of multi-drug-resistant fungi has caused rising healthcare costs and a decreased quality of life for patients wi …
Pathogenic fungi are an increasing health threat due to the rise in drug resistance. The limited number of antifungals currently avai …
Discovery of a Unique Set of Dog-Seroreactive Coccidioides Proteins Using Nucleic Acid Programmable Protein Array.
Koehler MA, Song L, Grill FJ, Shubitz LF, Powell DA, Galgiani JN, Orbach MJ, Robb EJ, Chung Y, Williams SA, Murugan V, Park JG, LaBaer J, Lake DF, Magee DM. Koehler MA, et al. J Fungi (Basel). 2024 Apr 24;10(5):307. doi: 10.3390/jof10050307. J Fungi (Basel). 2024. PMID: 38786662 Free PMC article.
Valley Fever (VF), caused by fungi in the genus Coccidioides, is a prevalent disease in southwestern and western parts of the United States that affects both humans and animals, such as dogs. ...
Valley Fever (VF), caused by fungi in the genus Coccidioides, is a prevalent disease in southwestern and western parts of the United
Effects of sEH inhibition on the eicosanoid and cytokine storms in SARS-CoV-2-infected mice.
Edin ML, Gruzdev A, Graves JP, Lih FB, Morisseau C, Ward JM, Hammock BD, Bosio CM, Zeldin DC. Edin ML, et al. FASEB J. 2024 May 31;38(10):e23692. doi: 10.1096/fj.202302202RR. FASEB J. 2024. PMID: 38786655
This study aimed to investigate the impact of sEH inhibition on the host response to SARS-CoV-2 infection in a mouse model with human angiotensin-converting enzyme 2 (ACE2) expression. Mice were infected with SARS-CoV-2 and treated with either vehicle or the sEH inhibitor …
This study aimed to investigate the impact of sEH inhibition on the host response to SARS-CoV-2 infection in a mouse model with human
Perceived Racial Discrimination, Psychological Distress, and Suicidal Behavior in Adolescence: Secondary Analysis of Cross-Sectional Data from a Statewide Youth Survey.
Cahill M, Illback R, Peiper N. Cahill M, et al. Healthcare (Basel). 2024 May 14;12(10):1011. doi: 10.3390/healthcare12101011. Healthcare (Basel). 2024. PMID: 38786419 Free PMC article.
Developmental, clinical, and epidemiological research have demonstrated the salience of perceived racial discrimination (PRD) as a contributor to negative mental health outcomes in adolescence. This article summarizes secondary analyses of cross-sectional data from a large …
Developmental, clinical, and epidemiological research have demonstrated the salience of perceived racial discrimination (PRD) as a contribut …
Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection.
Xie Q, Namba MD, Buck LA, Park K, Jackson JG, Barker JM. Xie Q, et al. Cells. 2024 May 20;13(10):882. doi: 10.3390/cells13100882. Cells. 2024. PMID: 38786105
HIV infection is an ongoing global health issue, despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. It is incr …
HIV infection is an ongoing global health issue, despite increased access to antiretroviral therapy (ART). People living with HIV (PL …
Cytosolic and Acrosomal pH Regulation in Mammalian Sperm.
Chávez JC, Carrasquel-Martínez G, Hernández-Garduño S, Matamoros Volante A, Treviño CL, Nishigaki T, Darszon A. Chávez JC, et al. Cells. 2024 May 17;13(10):865. doi: 10.3390/cells13100865. Cells. 2024. PMID: 38786087 Review.
hTERT-Immortalized Mesenchymal Stem Cell-Derived Extracellular Vesicles: Large-Scale Manufacturing, Cargo Profiling, and Functional Effects in Retinal Epithelial Cells.
Hindle J, Williams A, Kim Y, Kim D, Patil K, Khatkar P, Osgood Q, Nelson C, Routenberg DA, Howard M, Liotta LA, Kashanchi F, Branscome H. Hindle J, et al. Cells. 2024 May 17;13(10):861. doi: 10.3390/cells13100861. Cells. 2024. PMID: 38786083
Additionally, most of the literature focuses on EVs isolated from primary stem cells; the use of EVs isolated from human telomerase reverse transcriptase (hTERT)-immortalized stem cells has not been thoroughly examined. ...
Additionally, most of the literature focuses on EVs isolated from primary stem cells; the use of EVs isolated from human telomerase r …
A Scalable Histological Method to Embed and Section Multiple Brains Simultaneously.
Nwafor DC, Benkovic SA, Clary BL, Brichacek AL, Lambert HW, Zdilla MJ, Brown CM. Nwafor DC, et al. Cells. 2024 May 17;13(10):860. doi: 10.3390/cells13100860. Cells. 2024. PMID: 38786081
A large number of mouse brains are routinely used in experiments in neuroscience laboratories to evaluate several models of human diseases. Thus, methods are needed to reduce the time associated with processing brains for histology. ...Furthermore, we expand this method fo …
A large number of mouse brains are routinely used in experiments in neuroscience laboratories to evaluate several models of human dis …
CPEB3 Maintains Developmental Competence of the Oocyte.
Lamacova L, Jansova D, Jiang Z, Dvoran M, Aleshkina D, Iyyappan R, Jindrova A, Fan HY, Jiao Y, Susor A. Lamacova L, et al. Cells. 2024 May 16;13(10):850. doi: 10.3390/cells13100850. Cells. 2024. PMID: 38786074
Immune Cell Migration to Cancer.
Ryan AT, Kim M, Lim K. Ryan AT, et al. Cells. 2024 May 16;13(10):844. doi: 10.3390/cells13100844. Cells. 2024. PMID: 38786066 Review.
A Highly Sensitive Molecular Technique for RNA Virus Detection.
Rozmyslowicz T, Arévalo-Romero H, Conover DO, Fuentes-Pananá EM, León-Juárez M, Gaulton GN. Rozmyslowicz T, et al. Cells. 2024 May 9;13(10):804. doi: 10.3390/cells13100804. Cells. 2024. PMID: 38786028
We recently studied a detection system with great success in Mexico (Villahermosa, state of Tabasco), working with human sera from patients infected with those viruses. The research conducted in Mexico validated the efficacy of a novel two-step rapid isothermal amplificati …
We recently studied a detection system with great success in Mexico (Villahermosa, state of Tabasco), working with human sera from pa …
Protein Signature Differentiating Neutrophils and Myeloid-Derived Suppressor Cells Determined Using a Human Isogenic Cell Line Model and Protein Profiling.
Zhang Y, Hu J, Zhang X, Liang M, Wang X, Gan D, Li J, Lu X, Wan J, Feng S, Lu X. Zhang Y, et al. Cells. 2024 May 7;13(10):795. doi: 10.3390/cells13100795. Cells. 2024. PMID: 38786019
Recently, we reported the induced differentiation of isogenic PMNs or MDSCs (referred to as iPMNs and iMDSCs, respectively) from the human promyelocytic cell line HL60. Here, we profiled the global proteomics and membrane proteomics of these cells with quantitative mass sp …
Recently, we reported the induced differentiation of isogenic PMNs or MDSCs (referred to as iPMNs and iMDSCs, respectively) from the huma
Single-Cell Analyses Offer Insights into the Different Remodeling Programs of Arteries and Veins.
Rojas MG, Pereira-Simon S, Zigmond ZM, Varona Santos J, Perla M, Santos Falcon N, Stoyell-Conti FF, Salama A, Yang X, Long X, Duque JC, Salman LH, Tabbara M, Martinez L, Vazquez-Padron RI. Rojas MG, et al. Cells. 2024 May 7;13(10):793. doi: 10.3390/cells13100793. Cells. 2024. PMID: 38786017
The biological reasons for this discrepancy are not well understood, which is a limiting factor for the development of vein-targeted therapies. This study contrasts human peripheral arteries and veins at the single-cell level, with a focus on cell populations with remodeli …
The biological reasons for this discrepancy are not well understood, which is a limiting factor for the development of vein-targeted therapi …
3-Hydroxyanthranilic Acid Delays Paralysis in Caenorhabditis elegans Models of Amyloid-Beta and Polyglutamine Proteotoxicity.
Hull BT, Miller KM, Corban C, Backer G, Sheehan S, Korstanje R, Sutphin GL. Hull BT, et al. Biomolecules. 2024 May 18;14(5):599. doi: 10.3390/biom14050599. Biomolecules. 2024. PMID: 38786006
Alzheimer's disease is the most common form of dementia and a leading cause of death in the elderly population of the United States. No effective treatments for these diseases currently exist. Identifying effective treatments for Alzheimer's, Huntington's, and other …
Alzheimer's disease is the most common form of dementia and a leading cause of death in the elderly population of the United State
1,25-Dihydroxyvitamin D3 Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.
Johnson JR, Martini RN, Yuan YC, Woods-Burnham L, Walker M, Ortiz-Hernandez GL, Kobeissy F, Galloway D, Gaddy A, Oguejiofor C, Allen B, Lewis D, Davis MB, Kimbro KS, Yates CC, Murphy AB, Kittles RA. Johnson JR, et al. Biology (Basel). 2024 May 15;13(5):346. doi: 10.3390/biology13050346. Biology (Basel). 2024. PMID: 38785827
Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures.
Jagielnicki M, Kucharska I, Bennett BC, Harris AL, Yeager M. Jagielnicki M, et al. Biology (Basel). 2024 Apr 26;13(5):298. doi: 10.3390/biology13050298. Biology (Basel). 2024. PMID: 38785780 Review.
Abnormal GJC and HC communication can lead to numerous pathological states including inflammation, skin diseases, deafness, nervous system disorders, and cardiac arrhythmias. ...The NT domains under physiologic conditions display multiple conformational states, stab …
Abnormal GJC and HC communication can lead to numerous pathological states including inflammation, skin diseases, deafness, nervous s …
On an Aggregated Estimate for Human Mobility Regularities through Movement Trends and Population Density.
Vanni F, Lambert D. Vanni F, et al. Entropy (Basel). 2024 Apr 30;26(5):398. doi: 10.3390/e26050398. Entropy (Basel). 2024. PMID: 38785646
We explore and analyze two widely recognized entropy metrics: random entropy and uncorrelated Shannon entropy. These metrics are estimated through collective variables of human mobility, including movement trends and population density. ...
We explore and analyze two widely recognized entropy metrics: random entropy and uncorrelated Shannon entropy. These metrics are estimated t …
Evaluation of a Conference on Cancer-Related Financial and Legal Issues: A Potential Resource to Counter Financial Toxicity.
Ghazal LV, Doran J, Bryant M, Zebrack B, Liang MI. Ghazal LV, et al. Curr Oncol. 2024 May 15;31(5):2817-2835. doi: 10.3390/curroncol31050214. Curr Oncol. 2024. PMID: 38785495
This study describes the conception, development, and growth of the Triage Cancer Conference hosted by Triage Cancer, a national nonprofit organization providing free legal and financial education to the cancer community. ...Participants included social workers (33%), nurs …
This study describes the conception, development, and growth of the Triage Cancer Conference hosted by Triage Cancer, a national nonp …
DNA Quantity and Quality Comparisons between Cryopreserved and FFPE Tumors from Matched Pan-Cancer Samples.
Okojie J, O'Neal N, Burr M, Worley P, Packer I, Anderson D, Davis J, Kearns B, Fatema K, Dixon K, Barrott JJ. Okojie J, et al. Curr Oncol. 2024 Apr 28;31(5):2441-2452. doi: 10.3390/curroncol31050183. Curr Oncol. 2024. PMID: 38785464
We analyzed DNA metrics by performing a head-to-head comparison between FFPE and cryopreserved samples from 38 human tumors representing various cancer types. DNA quantity and purity were measured by UV spectrophotometry, and DNA from cryopreserved tissue demonstrated a 4. …
We analyzed DNA metrics by performing a head-to-head comparison between FFPE and cryopreserved samples from 38 human tumors represent …
Host obesity impacts genetic variation in influenza A viral populations.
Knoll M, Honce R, Meliopoulos V, Segredo-Otero EA, Johnson KE, Schultz-Cherry S, Ghedin E, Gresham D. Knoll M, et al. J Virol. 2024 May 24:e0177823. doi: 10.1128/jvi.01778-23. Online ahead of print. J Virol. 2024. PMID: 38785423
Our study suggests that obesity may result in a unique selective environment impacting intrahost IAV evolution, highlighting the need for additional genetic and functional studies to confirm these effects.IMPORTANCEObesity is a chronic health condition characterized by exc …
Our study suggests that obesity may result in a unique selective environment impacting intrahost IAV evolution, highlighting the need for ad …
Establishing the short course in transferable skills training program.
Lindsey ML, Harris BJ, Dahm LE, Woods L. Lindsey ML, et al. J Cell Physiol. 2024 May 24. doi: 10.1002/jcp.31324. Online ahead of print. J Cell Physiol. 2024. PMID: 38785335
To address this gap in training, the School of Graduate Studies at Meharry Medical College has developed the SHort Course In transFerable skills Training (SHIFT) Program, a 1-year professional development program accessible to graduate students in the United States
To address this gap in training, the School of Graduate Studies at Meharry Medical College has developed the SHort Course In transFerable sk …
Changes in CpG Methylation of the Vitellogenin 1 Promoter in Adult Male Zebrafish after Exposure to 17α-Ethynylestradiol.
Kolli RT, Glenn TC, Bringolf RB, Henderson M, Cummings BS, Kenneke JF. Kolli RT, et al. Environ Toxicol Chem. 2024 May 24. doi: 10.1002/etc.5879. Online ahead of print. Environ Toxicol Chem. 2024. PMID: 38785270
Environ Toxicol Chem 2024;00:1-10. 2024 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA....
Environ Toxicol Chem 2024;00:1-10. 2024 SETAC. This article has been contributed to by U.S. Government employees and their wor …
Daily social comparisons among women in midlife with elevated risk for cardiovascular disease: A within-person test of the identification/contrast model.
Baga K, Salvatore GM, Bercovitz I, Mogle JA, Arigo D. Baga K, et al. Appl Psychol Health Well Being. 2024 May 24. doi: 10.1111/aphw.12553. Online ahead of print. Appl Psychol Health Well Being. 2024. PMID: 38785210
Women age 40-60 are disproportionately affected by health problems that increase their risk for cardiovascular disease (CVD; e.g. hypertension). ...Future work should determine pathways between the immediate consequences of comparisons and longer-term health outcome …
Women age 40-60 are disproportionately affected by health problems that increase their risk for cardiovascular disease (CVD; e.g. hyp …
Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.
Iaccarino L, Llibre-Guerra JJ, McDade E, Edwards L, Gordon B, Benzinger T, Hassenstab J, Kramer JH, Li Y, Miller BL, Miller Z, Morris JC, Mundada N, Perrin RJ, Rosen HJ, Soleimani-Meigooni D, Strom A, Tsoy E, Wang G, Xiong C, Allegri R, Chrem P, Vazquez S, Berman SB, Chhatwal J, Masters CL, Farlow MR, Jucker M, Levin J, Salloway S, Fox NC, Day GS, Gorno-Tempini ML, Boxer AL, La Joie R, Bateman R, Rabinovici GD. Iaccarino L, et al. Brain Commun. 2024 May 3;6(3):fcae159. doi: 10.1093/braincomms/fcae159. eCollection 2024. Brain Commun. 2024. PMID: 38784820 Free PMC article.
Titanium dioxide nanotubes applied to conventional glass ionomer cement influence the expression of immunoinflammatory markers: An in vitro study.
Rangel-Coelho JP, Gogolla PV, Meyer MD, Simão LC, Costa BC, Casarin RCV, Santamaria MP, Teixeira LN, Peruzzo DC, Lisboa-Filho PN, Nociti-Jr FH, Kantovitz KR. Rangel-Coelho JP, et al. Heliyon. 2024 May 8;10(10):e30834. doi: 10.1016/j.heliyon.2024.e30834. eCollection 2024 May 30. Heliyon. 2024. PMID: 38784540 Free PMC article.
OBJECTIVES: To assess the impact of different concentrations TiO(2)-nt incorporated into a glass ionomer cement on the proliferation, mitochondrial metabolism, morphology, and pro- and anti-inflammatory cytokine production of cultured fibroblasts (NIH/3T3), whether or not …
OBJECTIVES: To assess the impact of different concentrations TiO(2)-nt incorporated into a glass ionomer cement on the proliferation, mitoch …
[Advances of monoclonal antibodies and analysis of marketed antibody drugs].
Gu G, Fang M. Gu G, et al. Sheng Wu Gong Cheng Xue Bao. 2024 May 25;40(5):1431-1447. doi: 10.13345/j.cjb.230779. Sheng Wu Gong Cheng Xue Bao. 2024. PMID: 38783807 Review. Chinese.
Throughout this process, their immunogenicity has gradually decreased, while their safety for human use steadily increased. Fully human antibodies are currently the safest form of antibody, because their sequences all come from human sources and they do not i …
Throughout this process, their immunogenicity has gradually decreased, while their safety for human use steadily increased. Fully …
Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking.
Neel AI, Wang Y, Sun H, Liontis KE, McCormack MC, Mayer JC, Cervera Juanes RP, Davenport AT, Grant KA, Daunais JD, Chen R. Neel AI, et al. J Neurochem. 2024 May 23. doi: 10.1111/jnc.16134. Online ahead of print. J Neurochem. 2024. PMID: 38783749
The dorsal striatum is composed of the caudate nucleus and the putamen in human and non-human primates. These two regions receive different cortical projections and are functionally distinct. ...
The dorsal striatum is composed of the caudate nucleus and the putamen in human and non-human primates. These two regions rece …
A review of the toxicity of ingredients in e-cigarettes, including those ingredients having the FDA's "Generally Recognized as Safe (GRAS)" regulatory status for use in food.
Kassem NOF, Strongin RM, Stroup AM, Brinkman MC, El-Hellani A, Erythropel HC, Etemadi A, Exil V, Goniewicz ML, Kassem NO, Klupinski TP, Liles S, Muthumalage T, Noël A, Peyton DH, Wang Q, Rahman I, Valerio LG Jr. Kassem NOF, et al. Nicotine Tob Res. 2024 May 24:ntae123. doi: 10.1093/ntr/ntae123. Online ahead of print. Nicotine Tob Res. 2024. PMID: 38783714
However, GRAS is a provision within the definition of a food additive under section 201(s) (21 U.S.C. 321(s)) of the U.S. Federal Food Drug and Cosmetic Act (FD&C Act). ...Such claims, typically placed on e-cigarette product labels and used in mark …
However, GRAS is a provision within the definition of a food additive under section 201(s) (21 U.S.C. 321(s)) of the U. …
Listeriosis in Poland in 2012-2021.
Księżak E, Sadkowska-Todys M. Księżak E, et al. Przegl Epidemiol. 2024 May 20;77(4):531-543. doi: 10.32394/pe.77.43. Przegl Epidemiol. 2024. PMID: 38783662 English, Polish.
MATERIAL AND METHODS: The analysis material consisted of data from individual epidemiological case reports on listeriosis submitted to the Department of Epidemiology of Infectious Diseases and Surveillance of the NIPH NIH - NRI by state sanitaryepidemiological stations in …
MATERIAL AND METHODS: The analysis material consisted of data from individual epidemiological case reports on listeriosis submitted to the D …
Giardioza (Lamblioza) w Polsce w 2021 roku.
Gordat K, Kitowska W, Sadkowska-Todys M. Gordat K, et al. Przegl Epidemiol. 2024 May 20;77(4):520-530. doi: 10.32394/pe.77.42. Przegl Epidemiol. 2024. PMID: 38783661 English, Polish.
Salmonellosis in Poland in 2021.
Milczarek M, Czarkowski MP, Sadkowska-Todys M. Milczarek M, et al. Przegl Epidemiol. 2024 May 20;77(4):504-519. doi: 10.32394/pe.77.41. Przegl Epidemiol. 2024. PMID: 38783660 English, Polish.
MATERIAL AND METHODS: The assessment of the epidemiological situation of salmonellosis in Poland was made on the basis of individual data on salmonellosis cases, entered by sanitary-epidemiological stations into the EpiBaza System, data on outbreaks caused by Salmonella bacilli f …
MATERIAL AND METHODS: The assessment of the epidemiological situation of salmonellosis in Poland was made on the basis of individual data on …
Measles in Poland in 2021.
Bogusz J, Paradowska-Stankiewicz I. Bogusz J, et al. Przegl Epidemiol. 2024 May 20;77(4):496-503. doi: 10.32394/pe.77.44. Przegl Epidemiol. 2024. PMID: 38783659 English, Polish.
This is a multi-year vaccination covered by an elimination program coordinated by the World Health Organization (WHO). Elimination of measles in the country is conditional on a 95% incidence of infection with two victims, monitoring the epidemiological situation, registeri …
This is a multi-year vaccination covered by an elimination program coordinated by the World Health Organization (WHO). Elimination of …
Chickenpox in Poland in 2021.
Bogusz J, Paradowska-Stankiewicz I. Bogusz J, et al. Przegl Epidemiol. 2024 May 20;77(4):489-495. doi: 10.32394/pe.77.40. Przegl Epidemiol. 2024. PMID: 38783658 English, Polish.
The lower incidence may have been the result of a decrease in the transmission of the chickenpox virus, the decrease in the number of cases has to do with, among other things, the restrictions put in place in connection with the COVID-19 pandemic, which result in, among other thi …
The lower incidence may have been the result of a decrease in the transmission of the chickenpox virus, the decrease in the number of cases …
Rubella in Poland in 2021.
Bogusz J, Paradowska-Stankiewicz I. Bogusz J, et al. Przegl Epidemiol. 2024 May 20;77(4):482-488. doi: 10.32394/pe.77.39. Przegl Epidemiol. 2024. PMID: 38783657 English, Polish.
Mumps in Poland in 2021.
Bogusz J, Paradowska-Stankiewicz I. Bogusz J, et al. Przegl Epidemiol. 2024 May 20;77(4):476-481. doi: 10.32394/pe.77.38. Przegl Epidemiol. 2024. PMID: 38783656 English, Polish.
Since 2003, vaccination against mumps has been mandatory in Poland, performed according to a two-dose schedule. As part of the Public Health Immunization Program (PSO), the MMR combination vaccine (against measles, mumps and rubella) is used for the entire population of ch …
Since 2003, vaccination against mumps has been mandatory in Poland, performed according to a two-dose schedule. As part of the Public Hea
Gonorrhoea in Poland in 2021.
Zakrzewska K, Niedźwiedzka-Stadnik M. Zakrzewska K, et al. Przegl Epidemiol. 2024 May 20;77(4):466-475. doi: 10.32394/pe/183994. Epub 2024 Apr 10. Przegl Epidemiol. 2024. PMID: 38783655 English, Polish.
Data on patients treated in dermatology-venereology clinics between 2019-2021 were taken from the Bulletins of the Ministry of Health. RESULTS: The incidence of gonorrhoea in Poland in 2021 was only a fraction of recorded in the EU/EEA (0.74 vs. 13.7/100000)-similar to the …
Data on patients treated in dermatology-venereology clinics between 2019-2021 were taken from the Bulletins of the Ministry of Health
Tuberculosis in Poland in 2021.
Korzeniewska-Koseła M, Wesołowski S. Korzeniewska-Koseła M, et al. Przegl Epidemiol. 2024 May 20;77(4):449-465. doi: 10.32394/pe.77.37. Epub 2024 Apr 9. Przegl Epidemiol. 2024. PMID: 38783654 English, Polish.
MATERIAL AND METHODS: Analysis of case-based data on TB patients from National TB Register, data on anti-TB drug susceptibility in cases notified in 2021, data from Statistics Poland on deaths from tuberculosis in 2020, data from National Institute of Public Heal
MATERIAL AND METHODS: Analysis of case-based data on TB patients from National TB Register, data on anti-TB drug susceptibility in ca …
HIV infections and AIDS cases in Poland in 2021 year.
Niedźwiedzka-Stadnik MA, Nowakowska-Radziwonka E, Kolenda A, Marzec-Bogusławska A. Niedźwiedzka-Stadnik MA, et al. Przegl Epidemiol. 2024 May 20;77(4):429-448. doi: 10.32394/pe/183578. Epub 2024 Apr 5. Przegl Epidemiol. 2024. PMID: 38783653 English, Polish.
A dataset on clients from Voluntary Testing and Counselling, coordinated by the National AIDS Center, which anonymously collects epidemiological and behaviour data on tested people was used. ...
A dataset on clients from Voluntary Testing and Counselling, coordinated by the National AIDS Center, which anonymously collects epid …
Longitudinal associations of plasma kynurenines and ratios with fatigue and quality of life in colorectal cancer survivors up to 12 months post-treatment.
Holthuijsen DDB, van Roekel EH, Bours MJL, Ueland PM, Breukink SO, Janssen-Heijnen MLG, Keulen ETP, Brezina S, Gigic B, Peoples AR, Ulrich CM, Ulvik A, Weijenberg MP, Eussen SJPM. Holthuijsen DDB, et al. Int J Cancer. 2024 May 23. doi: 10.1002/ijc.34992. Online ahead of print. Int J Cancer. 2024. PMID: 38783597
Fatigue is prevalent in colorectal cancer (CRC) survivors, impacting their health-related quality of life (HRQoL). Inflammation-induced activation of the kynurenine pathway may play a role in cancer-related fatigue and HRQoL, but evidence is scarce. ...
Fatigue is prevalent in colorectal cancer (CRC) survivors, impacting their health-related quality of life (HRQoL). Inflammation-induc …
Diagnoses of muscular dystrophy in a veterans health system.
Zingariello CD, Mohamed Y, Jorand-Fletcher M, Wymer J, Kang PB, Rasmussen SA. Zingariello CD, et al. Muscle Nerve. 2024 May 23. doi: 10.1002/mus.28112. Online ahead of print. Muscle Nerve. 2024. PMID: 38783566
However, it is not known whether veterans are sometimes diagnosed with milder forms of MD at a later timepoint. We aimed to determine the prevalence of MD in a veterans health system. METHODS: We abstracted clinical and genetic test data on patients who received care for a …
However, it is not known whether veterans are sometimes diagnosed with milder forms of MD at a later timepoint. We aimed to determine the pr …
Quantitation of tazemetostat in human plasma using liquid chromatography-tandem mass spectrometry.
Orleni M, Parise RA, Holleran JL, Amengual JE, Feng Y, Synold T, Beumer JH. Orleni M, et al. Biomed Chromatogr. 2024 May 23:e5903. doi: 10.1002/bmc.5903. Online ahead of print. Biomed Chromatogr. 2024. PMID: 38783541
To support a phase 1 trial in patients with lymphomas, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for tazemetostat quantitation in 20 muL of human plasma. After protein precipitation, chromatographic separation employed a Kinetex C18 co …
To support a phase 1 trial in patients with lymphomas, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for t …
HPTN 083-02: factors influencing adherence to injectable PrEP and retention in an injectable PrEP study.
Psaros C, Goodman GR, Lee JS, Rice W, Kelley CF, Oyedele T, Coelho LE, Phanuphak N, Singh Y, Middelkoop K, Griffith S, McCauley M, Rooney J, Rinehart AR, Clark J, Go V, Sugarman J, Fields SD, Adeyeye A, Grinsztejn B, Landovitz RJ, Safren SA; HPTN 083‐02 Study Team. Psaros C, et al. J Int AIDS Soc. 2024 May;27(5):e26252. doi: 10.1002/jia2.26252. J Int AIDS Soc. 2024. PMID: 38783534
Reasons for trial enrolment and PrEP use included a preference for using HIV prevention medication versus treatment in the event of HIV acquisition; the ability to enhance health via study-related education and services; access to a novel, convenient HIV prevention …
Reasons for trial enrolment and PrEP use included a preference for using HIV prevention medication versus treatment in the event of HIV acqu …
Mycophenolate mofetil vs. cyclophosphamide-based induction regimens for lupus nephritis: Outcomes at a tertiary care centre in Lahore, Pakistan.
Saeed MA, Khan A, Naeem F, Ahmad NM. Saeed MA, et al. J Pak Med Assoc. 2024 May;74(5):868-873. doi: 10.47391/JPMA.8694. J Pak Med Assoc. 2024. PMID: 38783432
For induction therapy, the patients were assigned at the discretion of the treating rheumatologist to mycophenolate mofetil group MMF, and intravenous cyclophosphamide group CYC. The latter group was further divided into NIH subgroup that received the therapy as per the pr …
For induction therapy, the patients were assigned at the discretion of the treating rheumatologist to mycophenolate mofetil group MMF, and i …
Transparency, reproducibility, and replicability of pharmacoepidemiology studies in a distributed network environment.
Rai A, Maro JC, Dutcher S, Bright P, Toh S. Rai A, et al. Pharmacoepidemiol Drug Saf. 2024 Jun;33(6):e5820. doi: 10.1002/pds.5820. Pharmacoepidemiol Drug Saf. 2024. PMID: 38783407
PURPOSE: Our objective is to describe how the U.S. Food and Drug Administration (FDA)'s Sentinel System implements best practices to ensure trust in drug safety studies using real-world data from disparate sources. ...
PURPOSE: Our objective is to describe how the U.S. Food and Drug Administration (FDA)'s Sentinel System implements best practi …
Determinants of implementation for group medical visits for patients with chronic pain: a systematic review.
Roth I, Tiedt M, Brintz C, Thompson-Lastad A, Ferguson G, Agha E, Holcomb J, Gardiner P, Leeman J. Roth I, et al. Implement Sci Commun. 2024 May 23;5(1):59. doi: 10.1186/s43058-024-00595-8. Implement Sci Commun. 2024. PMID: 38783388 Free PMC article. Review.
Common multi-level determinants included the relative advantage of GMVs for chronic pain over other available models, the capability and motivation of clinicians, the cost of GMVs to patients and the health system, the need and opportunity of patients, the availability of …
Common multi-level determinants included the relative advantage of GMVs for chronic pain over other available models, the capability and mot …
Transposon DNA sequences facilitate the tissue-specific gene transfer of circulating tumor DNA between human cells.
Cinar M, Martinez-Medina L, Puvvula PK, Arakelyan A, Vardarajan BN, Anthony N, Nagaraju GP, Park D, Feng L, Sheff F, Mosunjac M, Saxe D, Flygare S, Alese OB, Kaufman JL, Lonial S, Sarmiento JM, Lossos IS, Vertino PM, Lopez JA, El-Rayes B, Bernal-Mizrachi L. Cinar M, et al. Nucleic Acids Res. 2024 May 23:gkae427. doi: 10.1093/nar/gkae427. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38783375
We show that circulating tumor DNA (ctDNA) facilitates cell-specific gene transfer between human cancer cells and explain part of the mechanisms behind this phenomenon. ...
We show that circulating tumor DNA (ctDNA) facilitates cell-specific gene transfer between human cancer cells and explain part of the …
The influence of oviposition status on measures of transmission potential in malaria-infected mosquitoes depends on sugar availability.
Shiau JC, Garcia-Diaz N, Kyle DE, Pathak AK. Shiau JC, et al. Parasit Vectors. 2024 May 23;17(1):236. doi: 10.1186/s13071-024-06317-2. Parasit Vectors. 2024. PMID: 38783366 Free PMC article.
METHODS: Anopheles stephensi mosquitoes were infected with Plasmodium berghei, the rodent analog of human malaria, and maintained on 1% or 10% dextrose and either provided oviposition sites ('oviposited' herein) to complete their gonotrophic cycle or forced to retain eggs …
METHODS: Anopheles stephensi mosquitoes were infected with Plasmodium berghei, the rodent analog of human malaria, and maintained on …
30 years of youth system of care lessons learned - a qualitative study of Hawai'i's partnership with the Substance Abuse and Mental Health Services Administration.
Okamura KH, Jackson D, Ching DLC, Suh DE, Hartsock TLR, Hee PJ, Shimabukuro SK. Okamura KH, et al. BMC Health Serv Res. 2024 May 23;24(1):658. doi: 10.1186/s12913-024-11114-9. BMC Health Serv Res. 2024. PMID: 38783284 Free PMC article.
BACKGROUND: The Hawai'i State Department of Health, Child and Adolescent Mental Health Division (CAMHD) has maintained a longstanding partnership with Substance Abuse and Mental Health Services Administration (SAMHSA) to enhance capacity and quality of …
BACKGROUND: The Hawai'i State Department of Health, Child and Adolescent Mental Health Division (CAMHD) has maintained a longs …
Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight.
Koch ET, Cheng J, Ramandi D, Sepers MD, Hsu A, Fong T, Murphy TH, Yttri E, Raymond LA. Koch ET, et al. BMC Biol. 2024 May 23;22(1):121. doi: 10.1186/s12915-024-01919-9. BMC Biol. 2024. PMID: 38783261 Free PMC article.
The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. However, behavioural phenotypes are often subtle and progress slowly in this model. ...
The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. However, behav …
Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit.
Brown JA, Faley SL, Judge M, Ward P, Ihrie RA, Carson R, Armstrong L, Sahin M, Wikswo JP, Ess KC, Neely MD. Brown JA, et al. J Neurodev Disord. 2024 May 23;16(1):27. doi: 10.1186/s11689-024-09543-y. J Neurodev Disord. 2024. PMID: 38783199 Free PMC article.
METHODS: We generated TSC disease-specific cell models of the BBB by leveraging human induced pluripotent stem cell and microfluidic cell culture technologies. ...CONCLUSION: Our results demonstrate the utility of microphysiological systems to study human neurologic …
METHODS: We generated TSC disease-specific cell models of the BBB by leveraging human induced pluripotent stem cell and microfluidic …
naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation.
Bork F, Greve CL, Youn C, Chen S, N C Leal V, Wang Y, Fischer B, Nasri M, Focken J, Scheurer J, Engels P, Dubbelaar M, Hipp K, Zalat B, Szolek A, Wu MJ, Schittek B, Bugl S, Kufer TA, Löffler MW, Chamaillard M, Skokowa J, Kramer D, Archer NK, Weber ANR. Bork F, et al. EMBO Rep. 2024 May 23. doi: 10.1038/s44319-024-00150-5. Online ahead of print. EMBO Rep. 2024. PMID: 38783164
Severe infections as a gateway to dementia.
Kivimäki M, Walker KA. Kivimäki M, et al. Nat Aging. 2024 May 23. doi: 10.1038/s43587-024-00643-x. Online ahead of print. Nat Aging. 2024. PMID: 38783151 No abstract available.
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation.
Zinter MS, Dvorak CC, Mayday MY, Reyes G, Simon MR, Pearce EM, Kim H, Shaw PJ, Rowan CM, Auletta JJ, Martin PL, Godder K, Duncan CN, Lalefar NR, Kreml EM, Hume JR, Abdel-Azim H, Hurley C, Cuvelier GDE, Keating AK, Qayed M, Killinger JS, Fitzgerald JC, Hanna R, Mahadeo KM, Quigg TC, Satwani P, Castillo P, Gertz SJ, Moore TB, Hanisch B, Abdel-Mageed A, Phelan R, Davis DB, Hudspeth MP, Yanik GA, Pulsipher MA, Sulaiman I, Segal LN, Versluys BA, Lindemans CA, Boelens JJ, DeRisi JL; Pediatric Transplantation and Cell Therapy Consortium. Zinter MS, et al. Nat Med. 2024 May 23. doi: 10.1038/s41591-024-02999-4. Online ahead of print. Nat Med. 2024. PMID: 38783139
Here we used 278 bronchoalveolar lavage (BAL) fluid samples to study the lung microenvironment in 229 pediatric patients who have undergone HCT treated at 32 children's hospitals between 2014 and 2022. By leveraging paired microbiome and human gene expression data, we iden …
Here we used 278 bronchoalveolar lavage (BAL) fluid samples to study the lung microenvironment in 229 pediatric patients who have undergone …
Transcriptional regulation of living materials via extracellular electron transfer.
Graham AJ, Partipilo G, Dundas CM, Miniel Mahfoud IE, Halwachs KN, Holwerda AJ, Simmons TR, FitzSimons TM, Coleman SM, Rinehart R, Chiu D, Tyndall AE, Sajbel KC, Rosales AM, Keitz BK. Graham AJ, et al. Nat Chem Biol. 2024 May 23. doi: 10.1038/s41589-024-01628-y. Online ahead of print. Nat Chem Biol. 2024. PMID: 38783133
Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing.
Maier A, Hartung M, Abovsky M, Adamowicz K, Bader GD, Baier S, Blumenthal DB, Chen J, Elkjaer ML, Garcia-Hernandez C, Helmy M, Hoffmann M, Jurisica I, Kotlyar M, Lazareva O, Levi H, List M, Lobentanzer S, Loscalzo J, Malod-Dognin N, Manz Q, Matschinske J, Mee M, Oubounyt M, Pastrello C, Pico AR, Pillich RT, Poschenrieder JM, Pratt D, Pržulj N, Sadegh S, Saez-Rodriguez J, Sarkar S, Shaked G, Shamir R, Trummer N, Turhan U, Wang RS, Zolotareva O, Baumbach J. Maier A, et al. Nucleic Acids Res. 2024 May 23:gkae388. doi: 10.1093/nar/gkae388. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38783119
Next-generation IEDB tools: a platform for epitope prediction and analysis.
Yan Z, Kim K, Kim H, Ha B, Gambiez A, Bennett J, de Almeida Mendes MF, Trevizani R, Mahita J, Richardson E, Marrama D, Blazeska N, Koşaloğlu-Yalçın Z, Nielsen M, Sette A, Peters B, Greenbaum JA. Yan Z, et al. Nucleic Acids Res. 2024 May 23:gkae407. doi: 10.1093/nar/gkae407. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38783079
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells.
Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ. Lian X, et al. Nat Nanotechnol. 2024 May 23. doi: 10.1038/s41565-024-01680-8. Online ahead of print. Nat Nanotechnol. 2024. PMID: 38783058
CRISPR/Cas and base editing is achieved in a mouse model expressing human sickle cell disease phenotypes for potential foetal haemoglobin reactivation and conversion from sickle to non-sickle alleles. ...
CRISPR/Cas and base editing is achieved in a mouse model expressing human sickle cell disease phenotypes for potential foetal haemogl …
Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer.
Cyberski TF, Singh A, Korzinkin M, Mishra V, Pun F, Shen L, Wing C, Cheng X, Baird B, Miao Y, Elkabets M, Kochanny S, Guo W, Dyer E, Pearson AT, Juloori A, Lingen M, Cole G, Zhavoronkov A, Agrawal N, Izumchenko E, Rosenberg AJ. Cyberski TF, et al. NPJ Precis Oncol. 2024 May 23;8(1):114. doi: 10.1038/s41698-024-00606-w. NPJ Precis Oncol. 2024. PMID: 38783041 Free PMC article.
Structure and inhibition of the human lysosomal transporter Sialin.
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X. Schmiege P, et al. Nat Commun. 2024 May 23;15(1):4386. doi: 10.1038/s41467-024-48535-3. Nat Commun. 2024. PMID: 38782953 Free PMC article.
Here, we present the cryogenic electron-microscopy structures of human Sialin: apo cytosol-open, apo lumen-open, NAAG-bound, and inhibitor-bound. ...Moreover, functional analyses along with molecular dynamics simulations identify key residues in binding sialic acid and NAA …
Here, we present the cryogenic electron-microscopy structures of human Sialin: apo cytosol-open, apo lumen-open, NAAG-bound, and inhi …
Replicon particle vaccination induces non-neutralizing anti-nucleoprotein antibody-mediated control of Crimean-Congo hemorrhagic fever virus.
Sorvillo TE, Karaaslan E, Scholte FEM, Welch SR, Coleman-McCray JD, Genzer SC, Ritter JM, Hayes HM, Jain S, Pegan SD, Bergeron É, Montgomery JM, Spiropoulou CF, Spengler JR. Sorvillo TE, et al. NPJ Vaccines. 2024 May 23;9(1):88. doi: 10.1038/s41541-024-00877-1. NPJ Vaccines. 2024. PMID: 38782933 Free PMC article.
Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe human disease and is considered a WHO priority pathogen due to the lack of efficacious vaccines and antivirals. ...
Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe human disease and is considered a WHO priority pathogen due to the lac …
Transcriptomic analysis of subarachnoid cysts of Taenia solium reveals mechanisms for uncontrolled proliferation and adaptations to the microenvironment.
Orrego MA, Szczesniak MW, Vasquez CM, Verastegui MR, Bustos JA, Garcia HH, Nash TE; Cysticercosis Working Group in Peru. Orrego MA, et al. Sci Rep. 2024 May 23;14(1):11833. doi: 10.1038/s41598-024-61973-9. Sci Rep. 2024. PMID: 38782926 Free PMC article.
In contrast to vesicular parenchymal and ventricular located cysts that contain a viable scolex and are anlage of the adult tapeworm, the subarachnoid cyst proliferates to form aberrant membranous cystic masses within the subarachnoid spaces that cause mass effects and acute and …