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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 21
1947 23
1948 27
1949 31
1950 36
1951 47
1952 37
1953 27
1954 28
1955 23
1956 42
1957 31
1958 36
1959 31
1960 39
1961 39
1962 40
1963 78
1964 118
1965 154
1966 309
1967 378
1968 397
1969 353
1970 421
1971 353
1972 399
1973 492
1974 602
1975 672
1976 706
1977 879
1978 1686
1979 1946
1980 16807
1981 35159
1982 36317
1983 36924
1984 38476
1985 39388
1986 40504
1987 41878
1988 43160
1989 44898
1990 47096
1991 48861
1992 49393
1993 49943
1994 51400
1995 52130
1996 52412
1997 52989
1998 54471
1999 55806
2000 58001
2001 59524
2002 62693
2003 67278
2004 74941
2005 81897
2006 90994
2007 97599
2008 107892
2009 114078
2010 123448
2011 132909
2012 137846
2013 143231
2014 144726
2015 145437
2016 140168
2017 133984
2018 135148
2019 135247
2020 146912
2021 151598
2022 130929
2023 47783

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3,257,362 results

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Filters applied: . Clear all The following term was not found in PubMed: 5K99HL155845
Page 1
Using human induced pluripotent stem cell-derived liver cells to investigate the mechanisms of liver fibrosis in vitro.
Koui Y, Kido T. Koui Y, et al. Biochem Soc Trans. 2023 Jun 2:BST20221421. doi: 10.1042/BST20221421. Online ahead of print. Biochem Soc Trans. 2023. PMID: 37264940
Therefore, to investigate the mechanisms for liver fibrosis in vitro, it is necessary to develop an appropriate liver model that accurately recapitulates the pathology of human liver fibrosis including HSC activation. However, the supply of human cells is limited an …
Therefore, to investigate the mechanisms for liver fibrosis in vitro, it is necessary to develop an appropriate liver model that accurately …
Self-Assembly of DNA Nanostructures in Different Cations.
Rodriguez A, Gandavadi D, Mathivanan J, Song T, Madhanagopal BR, Talbot H, Sheng J, Wang X, Chandrasekaran AR. Rodriguez A, et al. Small. 2023 Jun 1:e2300040. doi: 10.1002/smll.202300040. Online ahead of print. Small. 2023. PMID: 37264756
High-sensitivity troponins and mortality in the general population.
McEvoy JW, Daya N, Tang O, Fang M, Ndumele CE, Coresh J, Christenson RH, Selvin E. McEvoy JW, et al. Eur Heart J. 2023 Jun 2:ehad328. doi: 10.1093/eurheartj/ehad328. Online ahead of print. Eur Heart J. 2023. PMID: 37264651
METHODS AND RESULTS: Among adults without cardiovascular disease in the 1999-2004 National Health and Nutrition Examination Survey, hs-troponin T was measured using one assay (Roche) and hs-troponin I using three assays (Abbott, Siemens, and Ortho). Cox regression w …
METHODS AND RESULTS: Among adults without cardiovascular disease in the 1999-2004 National Health and Nutrition Examination Su …
Acute pharmacodynamic responses to exenatide: Drug-induced increases in insulin secretion and glucose effectiveness.
Taylor SI, Montasser ME, Yuen AH, Fan H, Yazdi ZS, Whitlatch HB, Mitchell BD, Shuldiner AR, Muniyappa R, Streeten EA, Beitelshees AL. Taylor SI, et al. Diabetes Obes Metab. 2023 Jun 1. doi: 10.1111/dom.15143. Online ahead of print. Diabetes Obes Metab. 2023. PMID: 37264484
Minimal model analysis showed that exenatide increased glucose effectiveness (S(g) ) by 32% (p = .0008) but did not significantly affect insulin sensitivity (S(i) ). The exenatide-induced increase in insulin secretion made the largest contribution to interindividual …
Minimal model analysis showed that exenatide increased glucose effectiveness (S(g) ) by 32% (p = .0008) but did not significantly aff …
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.
Koga S, Metrick MA 2nd, Golbe LI, Santambrogio A, Kim M, Soto-Beasley AI, Walton RL, Baker MC, De Castro CF, DeTure M, Russell D, Navia BA, Sandiego C, Ross OA, Vendruscolo M, Caughey B, Dickson DW. Koga S, et al. Acta Neuropathol Commun. 2023 Jun 1;11(1):88. doi: 10.1186/s40478-023-01584-z. Acta Neuropathol Commun. 2023. PMID: 37264457
Using the intervention mapping for adaption framework to adapt an evidence-based sexual health intervention for youth affected by trauma.
Kachingwe ON, Lewis Q, Offiong A, Smith BD, LoVette A, Powell TW. Kachingwe ON, et al. BMC Public Health. 2023 Jun 1;23(1):1052. doi: 10.1186/s12889-023-15984-2. BMC Public Health. 2023. PMID: 37264451 Free PMC article.
METHODS: In this study, we describe the use of the Intervention Mapping for Adaption (IM-Adapt) framework to adapt an evidence-based, sexual health intervention (Focus on Youth with Informed Children and Parents). ...CONCLUSIONS: The adapted intervention shows promise towa …
METHODS: In this study, we describe the use of the Intervention Mapping for Adaption (IM-Adapt) framework to adapt an evidence-based, sexual …
Early miR-320b and miR-25-3p miRNA levels correlate with multiple sclerosis severity at 10 years: a cohort study.
Gonzalez-Martinez A, Bose G, Lokhande H, Saxena S, Healy BC, Polgar-Turcsanyi M, Weiner HL, Chitnis T. Gonzalez-Martinez A, et al. J Neuroinflammation. 2023 Jun 1;20(1):136. doi: 10.1186/s12974-023-02816-8. J Neuroinflammation. 2023. PMID: 37264432
MicroRNA (miRNA) are stable, non-coding molecules that have been identified in our Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB)-cohort, as well as other international cohorts, as potential disease biomarkers in …
MicroRNA (miRNA) are stable, non-coding molecules that have been identified in our Comprehensive Longitudinal Investigation of Multiple Scle …
Water, Sanitation, and Hygiene (WaSH) insecurity in unhoused communities of Los Angeles, California.
Avelar Portillo LJ, Kayser GL, Ko C, Vasquez A, Gonzalez J, Avelar DJ, Alvarenga N, Franklin M, Chiang YY. Avelar Portillo LJ, et al. Int J Equity Health. 2023 Jun 1;22(1):108. doi: 10.1186/s12939-023-01920-8. Int J Equity Health. 2023. PMID: 37264411
While WaSH insecurity is prevalent in many low and middle-income countries, it is also a problem in high-income countries, like the United States, as is evident in vulnerable populations, including people experiencing homelessness. ...We calculated frequencies and u …
While WaSH insecurity is prevalent in many low and middle-income countries, it is also a problem in high-income countries, like the Unite …
Epidemiological intelligence community network intervention: a community response for COVID-19 community transmission.
Marzan-Rodríguez M, Muniz-Rodriguez K, Morales LM, Martínez IS, Torres-Borrero N, Castro-Figueroa EM. Marzan-Rodríguez M, et al. BMC Public Health. 2023 Jun 1;23(1):1044. doi: 10.1186/s12889-023-15727-3. BMC Public Health. 2023. PMID: 37264399
We evaluated EpI-Net's community leaders' capacity-building component by assessing pre-post COVID-19 public health workshops' tests' score changes and satisfaction among trained community leaders. METHODS: A total of 24 community leaders from SVC in PR have complete …
We evaluated EpI-Net's community leaders' capacity-building component by assessing pre-post COVID-19 public health workshops' …
A qualitative exploration of barriers and facilitators to drug treatment services among people who inject drugs in west Virginia.
Winiker AK, Schneider KE, Hamilton White R, O'Rourke A, Grieb SM, Allen ST. Winiker AK, et al. Harm Reduct J. 2023 Jun 1;20(1):69. doi: 10.1186/s12954-023-00795-w. Harm Reduct J. 2023. PMID: 37264367
BACKGROUND: The opioid overdose crisis in the USA has called for expanding access to evidence-based substance use treatment programs, yet many barriers limit the ability of people who inject drugs (PWID) to engage in these programs. Predominantly rural states have been dis …
BACKGROUND: The opioid overdose crisis in the USA has called for expanding access to evidence-based substance use treatment programs, yet ma …
Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing.
Fauzia KA, Aftab H, Miftahussurur M, Waskito LA, Tuan VP, Alfaray RI, Matsumoto T, Yurugi M, Subsomwong P, Kabamba ET, Akada J, Yamaoka Y. Fauzia KA, et al. BMC Microbiol. 2023 Jun 1;23(1):159. doi: 10.1186/s12866-023-02889-8. BMC Microbiol. 2023. PMID: 37264297
BACKGROUND: Infection with Helicobacter pylori as the cause of gastric cancer is a global public health concern. In addition to protecting germs from antibiotics, biofilms reduce the efficacy of H. pylori eradication therapy. ...
BACKGROUND: Infection with Helicobacter pylori as the cause of gastric cancer is a global public health concern. In addition to prote …
Response from OLAW.
Brown P. Brown P. Lab Anim (NY). 2023 Jun;52(6):110. doi: 10.1038/s41684-023-01182-5. Lab Anim (NY). 2023. PMID: 37264235 No abstract available.
HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.
Lin Z, Bashirova AA, Viard M, Garner L, Quastel M, Beiersdorfer M, Kasprzak WK, Akdag M, Yuki Y, Ojeda P, Das S, Andresson T, Naranbhai V, Horowitz A, McMichael AJ, Hoelzemer A, Gillespie GM, Garcia-Beltran WF, Carrington M. Lin Z, et al. Nat Immunol. 2023 Jun 1. doi: 10.1038/s41590-023-01523-z. Online ahead of print. Nat Immunol. 2023. PMID: 37264229
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C receptors expressed on natural killer and T cell subsets. ...
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligan …
Comparison of quantitative FDG-PET and MRI in anti-LGI1 autoimmune encephalitis.
Sadaghiani MS, Roman S, Diaz-Arias LA, Habis R, Venkatesan A, Probasco JC, Solnes LB. Sadaghiani MS, et al. Neuroradiology. 2023 Jun 2. doi: 10.1007/s00234-023-03165-2. Online ahead of print. Neuroradiology. 2023. PMID: 37264220
Overall, the brain uptake during convalescence showed improvement of the Z scores towards 0 or normalization of previous hypometabolic activity in medial frontal cortex, inferior frontal cortex, Broca's region, parietotemporal cortex, and posterior cingulate cortex and pre …
Overall, the brain uptake during convalescence showed improvement of the Z scores towards 0 or normalization of previous hypometabolic activ …
Backcrossing to different parents produced two distinct hybrid species.
Wang D, Sun Y, Lei W, Zhu H, Wang J, Bi H, Feng S, Liu J, Ru D. Wang D, et al. Heredity (Edinb). 2023 Jun 1. doi: 10.1038/s41437-023-00630-9. Online ahead of print. Heredity (Edinb). 2023. PMID: 37264213
Our phylogenetic and coalescent analyses suggested that P. brachytyla s.s. arose from HHS between the ancestor of the PLSC before its diversification and P. wilsonii through an intermediate hybrid lineage at an early stage and backcrossing to the ancestral PL …
Our phylogenetic and coalescent analyses suggested that P. brachytyla s.s. arose from HHS between the ancestor of the P …
Genetically adjusted PSA levels for prostate cancer screening.
Kachuri L, Hoffmann TJ, Jiang Y, Berndt SI, Shelley JP, Schaffer KR, Machiela MJ, Freedman ND, Huang WY, Li SA, Easterlin R, Goodman PJ, Till C, Thompson I, Lilja H, Van Den Eeden SK, Chanock SJ, Haiman CA, Conti DV, Klein RJ, Mosley JD, Graff RE, Witte JS. Kachuri L, et al. Nat Med. 2023 Jun 1. doi: 10.1038/s41591-023-02277-9. Online ahead of print. Nat Med. 2023. PMID: 37264206
Genomic profiling informs diagnoses and treatment in vascular anomalies.
Li D, Sheppard SE, March ME, Battig MR, Surrey LF, Srinivasan AS, Matsuoka LS, Tian L, Wang F, Seiler C, Dayneka J, Borst AJ, Matos MC, Paulissen SM, Krishnamurthy G, Nriagu B, Sikder T, Casey M, Williams L, Rangu S, O'Connor N, Thomas A, Pinto E, Hou C, Nguyen K, Pellegrino da Silva R, Chehimi SN, Kao C, Biroc L, Britt AD, Queenan M, Reid JR, Napoli JA, Low DM, Vatsky S, Treat J, Smith CL, Cahill AM, Snyder KM, Adams DM, Dori Y, Hakonarson H. Li D, et al. Nat Med. 2023 Jun 1. doi: 10.1038/s41591-023-02364-x. Online ahead of print. Nat Med. 2023. PMID: 37264205
Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism.
Han L, Huang D, Wu S, Liu S, Wang C, Sheng Y, Lu X, Broxmeyer HE, Wan J, Yang L. Han L, et al. Nat Cell Biol. 2023 Jun 1. doi: 10.1038/s41556-023-01162-4. Online ahead of print. Nat Cell Biol. 2023. PMID: 37264180
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic disorder-associated heart diseases. Here we identify a human long non-coding RNA, Lipid-Droplet Transporter (LIPTER), essential for LD tra …
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic disor …
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.
Bellfy L, Smies CW, Bernhardt AR, Bodinayake KK, Sebastian A, Stuart EM, Wright DS, Lo CY, Murakami S, Boyd HM, von Abo MJ, Albert I, Kwapis JL. Bellfy L, et al. Neuropsychopharmacology. 2023 Jun 1. doi: 10.1038/s41386-023-01616-1. Online ahead of print. Neuropsychopharmacology. 2023. PMID: 37264172
While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, downstream "satellite clocks" may also regulate local functions based on the time of day. ...
While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, downstream "satellite clocks" may also regulate l …
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease.
Sun N, Akay LA, Murdock MH, Park Y, Galiana-Melendez F, Bubnys A, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai LH, Kellis M. Sun N, et al. Nat Neurosci. 2023 Jun 1. doi: 10.1038/s41593-023-01334-3. Online ahead of print. Nat Neurosci. 2023. PMID: 37264161
Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes that occur in specific cell types have not been fully characterized. Here, we profile single-nucleus transcriptomes in the human cerebrovasculature in six brain regions from 220 …
Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes that occur in specific cell types have not b …
Glymphatic influx and clearance are accelerated by neurovascular coupling.
Holstein-Rønsbo S, Gan Y, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, Kelley DH, Nedergaard M. Holstein-Rønsbo S, et al. Nat Neurosci. 2023 Jun 1. doi: 10.1038/s41593-023-01327-2. Online ahead of print. Nat Neurosci. 2023. PMID: 37264158
The stop and go of glymphatic flow.
Kılıç K, Devor A. Kılıç K, et al. Nat Neurosci. 2023 Jun 1. doi: 10.1038/s41593-023-01344-1. Online ahead of print. Nat Neurosci. 2023. PMID: 37264157 No abstract available.
Augmenting hippocampal-prefrontal neuronal synchrony during sleep enhances memory consolidation in humans.
Geva-Sagiv M, Mankin EA, Eliashiv D, Epstein S, Cherry N, Kalender G, Tchemodanov N, Nir Y, Fried I. Geva-Sagiv M, et al. Nat Neurosci. 2023 Jun 1. doi: 10.1038/s41593-023-01324-5. Online ahead of print. Nat Neurosci. 2023. PMID: 37264156
Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex during sleep and tested its effects on sleep electrophysiology and on overnight consolidation of declarative memory. ...Our results indicate that hippocampo-thalamocortical synchro …
Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex during sleep and tested its effects on s …
Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer.
Barrera C, Corredor G, Viswanathan VS, Ding R, Toro P, Fu P, Buzzy C, Lu C, Velu P, Zens P, Berezowska S, Belete M, Balli D, Chang H, Baxi V, Syrigos K, Rimm DL, Velcheti V, Schalper K, Romero E, Madabhushi A. Barrera C, et al. NPJ Precis Oncol. 2023 Jun 1;7(1):52. doi: 10.1038/s41698-023-00403-x. NPJ Precis Oncol. 2023. PMID: 37264091
Consequently, merely measuring the amount of tumor-infiltrating lymphocytes (TILs) may not accurately reflect the complexity of tumor-immune interactions and T-cell functional states and may not be valuable as a treatment-specific biomarker. ...PhenoTIL is a novel computat …
Consequently, merely measuring the amount of tumor-infiltrating lymphocytes (TILs) may not accurately reflect the complexity of tumor-immune …
On the thermodynamics of DNA methylation process.
Sanchez R, Mackenzie SA. Sanchez R, et al. Sci Rep. 2023 Jun 1;13(1):8914. doi: 10.1038/s41598-023-35166-9. Sci Rep. 2023. PMID: 37264042
A central tenet of this argument is that the probability density function of DNA methylation information-divergence summarizes the statistical biophysics underlying spontaneous methylation background and implicitly bears on the channel capacity of molecular machines conforming to …
A central tenet of this argument is that the probability density function of DNA methylation information-divergence summarizes the statistic …
Selective Scatterings of Phonons and Electrons in Defective Half-Heusler Nb1- δ CoSb for the Figure of Merit zT > 1.
Gao Z, Xia K, Nan P, Yin L, Hu C, Li A, Han S, Zhang M, Chen M, Ge B, Zhang Q, Fu C, Zhu T. Gao Z, et al. Small. 2023 Jun 1:e2302457. doi: 10.1002/smll.202302457. Online ahead of print. Small. 2023. PMID: 37263990
The recently developed defective 19-electron half-Heusler (HH) compounds, represented by Nb(1-) (delta) CoSb, possess massive intrinsic vacancies at the cation site and thus intrinsically low lattice thermal conductivity that is desirable for thermoelectric (TE) applications. Yet …
The recently developed defective 19-electron half-Heusler (HH) compounds, represented by Nb(1-) (delta) CoSb, possess massive intrinsic vaca …
Acculturative Stress, Mental Health, and Well-Being among Deaf Adults.
Aldalur A, Pick LH. Aldalur A, et al. J Deaf Stud Deaf Educ. 2023 Jun 1:enad015. doi: 10.1093/deafed/enad015. Online ahead of print. J Deaf Stud Deaf Educ. 2023. PMID: 37263967
Acculturative stress is associated with negative mental health among culturally diverse individuals. Deaf and Hard-of-Hearing (DHH) individuals experience acculturative stress as they navigate within and between the Hearing and Deaf communities, yet, research has not exami …
Acculturative stress is associated with negative mental health among culturally diverse individuals. Deaf and Hard-of-Hearing (DHH) i …
Albumin nanoparticles with tunable ultraviolet-to-red autofluorescence for label-free cell imaging and selective biosensing of copper ion.
Borlan R, Soritau O, Maniu D, Hada AM, Florea A, Astilean S, Focsan M. Borlan R, et al. Int J Biol Macromol. 2023 May 30:125129. doi: 10.1016/j.ijbiomac.2023.125129. Online ahead of print. Int J Biol Macromol. 2023. PMID: 37263331
In addition, a lack of toxicity and good cellular uptake were observed and the ultraviolet-to-red intrinsic fluorescence of the albumin nanoparticles was preserved when tested in vitro on NIH:OVCAR3 cell line. Preliminary studies confirm the albumin nanoparticles' ability …
In addition, a lack of toxicity and good cellular uptake were observed and the ultraviolet-to-red intrinsic fluorescence of the albumin nano …
Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions.
Shazeeb MS, Moholkar V, King RM, Vedantham S, Vardar Z, Kraitem A, Lindsay C, Anagnostakou V, Singh J, Massari F, de Macedo Rodrigues K, Naragum V, Puri AS, Carniato S, Gounis MJ, Kühn AL. Shazeeb MS, et al. J Clin Neurosci. 2023 May 29;113:121-125. doi: 10.1016/j.jocn.2023.05.014. Online ahead of print. J Clin Neurosci. 2023. PMID: 37262981
The purpose of this retrospective study was to determine how neurointerventionalists consider the physical nature of carotid segments when evaluating a procedure's difficulty. METHODS: Seven neurointerventionalists reviewed 3D reconstructions of CT angiograms of left and r …
The purpose of this retrospective study was to determine how neurointerventionalists consider the physical nature of carotid segments when e …
Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.
Khrom M, Li D, Naito T, Lee HS, Botwin GJ, Potdar AA, Boucher G; NIDDK Inflammatory Bowel Disease Genetics Consortium; International Inflammatory Bowel Disease Genetics Consortium; Yang S, Mengesha E, Dube S, Song K, McGovern DPB, Haritunians T. Khrom M, et al. Inflamm Bowel Dis. 2023 Jun 1:izad089. doi: 10.1093/ibd/izad089. Online ahead of print. Inflamm Bowel Dis. 2023. PMID: 37262302

RESULTS: We identified significant differences between sexes for disease location and perianal complication in Crohn's disease and disease extent in ulcerative colitis. We observed genome-wide-significant sex-dimorphic associations (P < 5 10-8) at loci not previously re

…
RESULTS: We identified significant differences between sexes for disease location and perianal complication in Crohn's disease and di …
Redox regulation in diabetic kidney disease.
Daehn IS, Ekperikpe US, Stadler K. Daehn IS, et al. Am J Physiol Renal Physiol. 2023 Jun 1. doi: 10.1152/ajprenal.00047.2023. Online ahead of print. Am J Physiol Renal Physiol. 2023. PMID: 37262088 Review.
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer.
Zhu C, Soto-Feliciano YM, Morris JP 4th, Huang CH, Koche RP, Ho YJ, Banito A, Chen CD, Shroff A, Tian S, Livshits G, Chen CC, Fennell M, Armstrong SA, Allis CD, Tschaharganeh DF, Lowe SW. Zhu C, et al. Elife. 2023 Jun 1;12:e80854. doi: 10.7554/eLife.80854. Online ahead of print. Elife. 2023. PMID: 37261974
Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemia family member 3 (MLL3, encoded b …
Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events …
What predicts interdependence with family? The relative contributions of ethnicity/race and social class.
Hooker ED, Corona K, Guardino CM, Schetter CD, Campos B. Hooker ED, et al. Cultur Divers Ethnic Minor Psychol. 2023 Jun 1. doi: 10.1037/cdp0000593. Online ahead of print. Cultur Divers Ethnic Minor Psychol. 2023. PMID: 37261795
OBJECTIVE: Interdependence with family is considered a core element of collectivistic cultures, and it is routinely endorsed by people of ethnic/racial minority backgrounds in the United States. In contrast, a preference for independence from family is characteristi …
OBJECTIVE: Interdependence with family is considered a core element of collectivistic cultures, and it is routinely endorsed by people of et …
Firearm ownership and storage practices among United States firefighters and emergency medical services personnel.
Stanley IH, Lebeaut A, Betz ME, Wright A, Vujanovic AA. Stanley IH, et al. Psychol Serv. 2023 Jun 1. doi: 10.1037/ser0000780. Online ahead of print. Psychol Serv. 2023. PMID: 37261761
Compared with the general U.S. population, firefighters (FF) and emergency medical services (EMS) workers (FF + EMS personnel) are at increased risk for firearm suicide. Although secure firearm storage is associated with reduced risk of firearm suicide, no st …
Compared with the general U.S. population, firefighters (FF) and emergency medical services (EMS) workers (FF + EMS per …
E-Connect: Linking probation youth at risk for suicide to behavioral health services.
Elkington KS, Wasserman GA, Ryan ME, Sichel CE, Sarapas C, Dennis ML, Taxman FS. Elkington KS, et al. J Consult Clin Psychol. 2023 Jun 1. doi: 10.1037/ccp0000824. Online ahead of print. J Consult Clin Psychol. 2023. PMID: 37261738
OBJECTIVE: Youth involved in the justice system (YIJ) have higher rates of suicidal thoughts and behaviors (STB) and associated behavioral health (BH) problems, yet lower levels of service use compared to youth in the general population. This study examined the efficacy of …
OBJECTIVE: Youth involved in the justice system (YIJ) have higher rates of suicidal thoughts and behaviors (STB) and associated behavioral …
Factors associated with weight gain in pre- and post-menopausal women receiving adjuvant endocrine therapy for breast cancer.
Uhelski AR, Blackford AL, Sheng JY, Snyder C, Lehman J, Visvanathan K, Lim D, Stearns V, Smith KL. Uhelski AR, et al. J Cancer Surviv. 2023 Jun 1. doi: 10.1007/s11764-023-01408-y. Online ahead of print. J Cancer Surviv. 2023. PMID: 37261654
PURPOSE: Weight gain after breast cancer poses health risks. We aimed to identify factors associated with weight gain during adjuvant endocrine therapy (AET). ...
PURPOSE: Weight gain after breast cancer poses health risks. We aimed to identify factors associated with weight gain during adjuvant …
Correlates of Stigma Toward Mental Health Service Use Among Filipino Americans and Korean Americans.
Park M, Choi Y, Cabassa LJ, Yasui M, Takeuchi D. Park M, et al. J Immigr Minor Health. 2023 Jun 1. doi: 10.1007/s10903-023-01494-1. Online ahead of print. J Immigr Minor Health. 2023. PMID: 37261646
Asian Americans are less likely than Whites to seek mental care and when they do, there is a substantial delay in help-seeking. Stigma associated with mental health service use is one of the major barriers to help-seeking among Asian Americans. ...Using a cross-sectional s …
Asian Americans are less likely than Whites to seek mental care and when they do, there is a substantial delay in help-seeking. Stigma assoc …
Leveraging the Full Continuum of Care to Prevent Opioid Use Disorder.
Cance JD, Adams ET, D'Amico EJ, Palimaru A, Fernandes CSF, Fiellin LE, Bonar EE, Walton MA, Komro KA, Knight D, Knight K, Rao V, Youn S, Saavedra L, Ridenour TA, Deeds B. Cance JD, et al. Prev Sci. 2023 Jun 1. doi: 10.1007/s11121-023-01545-x. Online ahead of print. Prev Sci. 2023. PMID: 37261635
Cost of Implementing an Evidence-Based Intervention to Support Safer Use of Antipsychotics in Youth.
Chavez LJ, Richards JE, Fishman P, Yeung K, Renz A, Quintana LM, Massimino S, Penfold RB. Chavez LJ, et al. Adm Policy Ment Health. 2023 Jun 1. doi: 10.1007/s10488-023-01273-y. Online ahead of print. Adm Policy Ment Health. 2023. PMID: 37261566
We calculate the costs of implementing a psychiatric consultation and navigation program for youth prescribed antipsychotic medications across 4 health systems, which included an electronic health record (EHR) decision support tool, consultation with a child and ado …
We calculate the costs of implementing a psychiatric consultation and navigation program for youth prescribed antipsychotic medications acro …
Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells.
Reyes Fernandez PC, Wright CS, Farach-Carson MC, Thompson WR. Reyes Fernandez PC, et al. Calcif Tissue Int. 2023 Jun 1. doi: 10.1007/s00223-023-01097-w. Online ahead of print. Calcif Tissue Int. 2023. PMID: 37261463 Review.
Because VSCCs are druggable, a better understanding of the multiple functions of these channels in the skeleton offers the opportunity for developing new therapies to enhance and maintain bone and to improve systemic health....
Because VSCCs are druggable, a better understanding of the multiple functions of these channels in the skeleton offers the opportunity for d …
Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis.
Kim TS, Silva LM, Theofilou VI, Greenwell-Wild T, Li L, Williams DW, Ikeuchi T, Brenchley L; NIDCD/NIDCR Genomics and Computational Biology Core; Bugge TH, Diaz PI, Kaplan MJ, Carmona-Rivera C, Moutsopoulos NM. Kim TS, et al. J Exp Med. 2023 Sep 4;220(9):e20221751. doi: 10.1084/jem.20221751. Epub 2023 Jun 1. J Exp Med. 2023. PMID: 37261457
Investigating mechanisms by which NETs drive inflammatory bone loss, we find that extracellular histones, a major component of NETs, trigger upregulation of IL-17/Th17 responses, and bone destruction. Importantly, human findings corroborate our experimental work. We docume …
Investigating mechanisms by which NETs drive inflammatory bone loss, we find that extracellular histones, a major component of NETs, trigger …
Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches.
Gomez-Salazar MA, Wang Y, Thottappillil N, Hardy RW, Alexandre M, Höller F, Martin N, Gonzalez-Galofre ZN, Stefancova D, Medici D, James AW, Péault B. Gomez-Salazar MA, et al. Stem Cells Transl Med. 2023 Jun 1:szad024. doi: 10.1093/stcltm/szad024. Online ahead of print. Stem Cells Transl Med. 2023. PMID: 37261440
We evaluated herein the activity of aldehyde dehydrogenase, a family of enzymes catalyzing the oxidation of aldehydes into carboxylic acids and a reported biomarker of normal and malignant stem cells, within human adipose tissue perivascular areas. A progression of ALDHLow …
We evaluated herein the activity of aldehyde dehydrogenase, a family of enzymes catalyzing the oxidation of aldehydes into carboxylic acids …
Flexible control of representational dynamics in a disinhibition-based model of decision making.
Shen B, Louie K, Glimcher PW. Shen B, et al. Elife. 2023 Jun 1;12:e82426. doi: 10.7554/eLife.82426. Online ahead of print. Elife. 2023. PMID: 37261426
Furthermore, the biological basis of disinhibition provides a simple mechanism for flexible top-down control of the network states, enabling the circuit to capture diverse task-dependent neural dynamics. ...
Furthermore, the biological basis of disinhibition provides a simple mechanism for flexible top-down control of the network states, e …
Nutrient regulation of development and cell fate decisions.
Tu WB, Christofk HR, Plath K. Tu WB, et al. Development. 2023 Oct 15;150(20):dev199961. doi: 10.1242/dev.199961. Epub 2023 Jun 1. Development. 2023. PMID: 37260407
Diet contributes to health at all stages of life, from embryonic development to old age. ...
Diet contributes to health at all stages of life, from embryonic development to old age. ...
Pericytes Contribute to Flow-induced Pulmonary Hypertension.
Klouda T, Tsikis ST, Kim H, Liu T, Visner G, Fernandez-Gonzalez A, Kourembanas S, Puder M, Raby B, Yuan K. Klouda T, et al. Am J Respir Cell Mol Biol. 2023 Jun;68(6):705-708. doi: 10.1165/rcmb.2022-0427LE. Am J Respir Cell Mol Biol. 2023. PMID: 37260177 No abstract available.
June Highlights/Papers by Junior Investigators/NIH News.
[No authors listed] [No authors listed] Am J Respir Cell Mol Biol. 2023 Jun;68(6):iii. doi: 10.1165/rcmb.68i6RedAlert. Am J Respir Cell Mol Biol. 2023. PMID: 37260175 No abstract available.
Incidence, demographics, and survival of malignant hemangioendothelioma in the United States.
Paulson KG, Ravi V, Rubin BP, Park M, Loggers ET, Cranmer LD, Wagner MJ. Paulson KG, et al. Cancer Med. 2023 Jun 1. doi: 10.1002/cam4.6181. Online ahead of print. Cancer Med. 2023. PMID: 37260142
METHODS: This retrospective analysis used the US Cancer Statistics National Program of Cancer Registries - Surveillance Epidemiology End Results (SEER) combined database to identify patients in the US newly diagnosed with hemangioendothelioma between the years of 2001 and …
METHODS: This retrospective analysis used the US Cancer Statistics National Program of Cancer Registries - Surveillance Epidemiology …
No clinically significant differences in patient-reported outcome measures across total hip arthroplasty approaches.
Kim AG, Rizk AA, Chiu AM, Zuke W, Acuña AJ, Kamath AF. Kim AG, et al. Hip Int. 2023 Jun 1:11207000231178722. doi: 10.1177/11207000231178722. Online ahead of print. Hip Int. 2023. PMID: 37260099
RESULTS: No differences between the DAA and other approaches were observed when evaluating HOOS (MD -0.28; 95% CI, -1.98-1.41; p = 0.74), HHS (MD 2.38; 95% CI, -0.27-5.03; p = 0.08), OHS (MD 1.35; 95% CI, -2.00-4.71; p = 0.43), FJS-12 (MD 5.88; 95% CI, -0.36-12.12; p = 0.0 …
RESULTS: No differences between the DAA and other approaches were observed when evaluating HOOS (MD -0.28; 95% CI, -1.98-1.41; p = 0.74), …
Thumb-domain dynamics modulate the functional repertoire of DNA-Polymerase IV (DinB).
Okeke DC, Lidman J, Matečko-Burmann I, Burmann BM. Okeke DC, et al. Nucleic Acids Res. 2023 Jun 1:gkad490. doi: 10.1093/nar/gkad490. Online ahead of print. Nucleic Acids Res. 2023. PMID: 37260088
In this study, we use advanced solution NMR spectroscopy methods in combination with biophysical characterization to elucidate the crucial role of the Thumb domain within DinB's functional cycle. We find that the inherent dynamics of this domain guide the recognition of do …
In this study, we use advanced solution NMR spectroscopy methods in combination with biophysical characterization to elucidate the crucial r …
ARMADiLLO: a web server for analyzing antibody mutation probabilities.
Martin Beem JS, Venkatayogi S, Haynes BF, Wiehe K. Martin Beem JS, et al. Nucleic Acids Res. 2023 Jun 1:gkad398. doi: 10.1093/nar/gkad398. Online ahead of print. Nucleic Acids Res. 2023. PMID: 37260077
The ARMADiLLO web server also contains precomputed results reporting the probability of amino acid substitutions in all human V gene segments and in a collection of HIV broadly neutralizing antibodies....
The ARMADiLLO web server also contains precomputed results reporting the probability of amino acid substitutions in all human V gene …
Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.
Li D, Farrell JJ, Mez J, Martin ER, Bush WS, Ruiz A, Boada M, de Rojas I, Mayeux R, Haines JL, Vance MAP, Wang LS, Schellenberg GD, Lunetta KL, Farrer LA. Li D, et al. Alzheimers Dement. 2023 Jun 1. doi: 10.1002/alz.13117. Online ahead of print. Alzheimers Dement. 2023. PMID: 37260021
INTRODUCTION: Most Alzheimer's disease (AD) loci have been discovered in individuals with European ancestry (EA). ...
INTRODUCTION: Most Alzheimer's disease (AD) loci have been discovered in individuals with European ancestry (EA). ...
Predicting FDG-PET Images From Multi-Contrast MRI Using Deep Learning in Patients With Brain Neoplasms.
Ouyang J, Chen KT, Duarte Armindo R, Davidzon GA, Hawk KE, Moradi F, Rosenberg J, Lan E, Zhang H, Zaharchuk G. Ouyang J, et al. J Magn Reson Imaging. 2023 Jun 1. doi: 10.1002/jmri.28837. Online ahead of print. J Magn Reson Imaging. 2023. PMID: 37259967
STATISTICAL TESTS: The agreement in ratings between the acquired and synthesized PET were tested with Gwet's AC and exact Bowker test of symmetry. Agreement of the readers was assessed by Gwet's AC. ...
STATISTICAL TESTS: The agreement in ratings between the acquired and synthesized PET were tested with Gwet's AC and exact Bowker test …
Relationship between quantitative digital behavioral features and clinical profiles in young autistic children.
Coffman M, Di Martino JM, Aiello R, Carpenter KLH, Chang Z, Compton S, Eichner B, Espinosa S, Flowers J, Franz L, Perochon S, Krishnappa Babu PR, Sapiro G, Dawson G. Coffman M, et al. Autism Res. 2023 Jun 1. doi: 10.1002/aur.2955. Online ahead of print. Autism Res. 2023. PMID: 37259909
Early behavioral markers for autism include differences in social attention and orienting in response to one's name when called, and differences in body movements and motor abilities. ...Two language-related behaviors measured via the app, attention to people during a conv …
Early behavioral markers for autism include differences in social attention and orienting in response to one's name when called, and …
Cytoplasmic tail of mechanosensitive channel Pkd2 regulates its internalization and clustering in eisosome.
Malla M, Sinha D, Chowdhury P, Bisesi BT, Chen Q. Malla M, et al. J Cell Sci. 2023 Jun 1:jcs.260598. doi: 10.1242/jcs.260598. Online ahead of print. J Cell Sci. 2023. PMID: 37259828
Polycystins are a family of conserved ion channels, mutations of which lead to one of the most common human genetic disorders Autosomal Dominant Polycystic Kidney Disease. ...
Polycystins are a family of conserved ion channels, mutations of which lead to one of the most common human genetic disorders Autosom …
Chronic prostatitis as possible risk factor for Peyronie's disease: Psychological, sexual and prostatitis-like symptoms in patients with PD.
Paulis G, Paulis A. Paulis G, et al. Arch Ital Urol Androl. 2023 May 31:11406. doi: 10.4081/aiua.2023.11406. Online ahead of print. Arch Ital Urol Androl. 2023. PMID: 37259816
OBJECTIVE: This study aims to investigate a possible relationship between chronic prostatitis (CP) and Peyronie's disease (PD) and to characterize the psychological profile of patients suffering from PD, with or without concomitant CP. ...All 539 PD patients underwent phot …
OBJECTIVE: This study aims to investigate a possible relationship between chronic prostatitis (CP) and Peyronie's disease (PD) and to …
Epigenetic aging in older breast cancer survivors and non-cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study.
Rentscher KE, Bethea TN, Zhai W, Small BJ, Zhou X, Ahles TA, Ahn J, Breen EC, Cohen HJ, Extermann M, Graham DMA, Jim HSL, McDonald BC, Nakamura ZM, Patel SK, Root JC, Saykin AJ, Van Dyk K, Mandelblatt JS, Carroll JE. Rentscher KE, et al. Cancer. 2023 Jun 1. doi: 10.1002/cncr.34818. Online ahead of print. Cancer. 2023. PMID: 37259669
Testing associations between human anxiety and genes previously implicated by mouse anxiety models.
Brasher MS, Mize TJ, Thomas AL, Hoeffer CA, Ehringer MA, Evans LM. Brasher MS, et al. Genes Brain Behav. 2023 May 31:e12851. doi: 10.1111/gbb.12851. Online ahead of print. Genes Brain Behav. 2023. PMID: 37259642
When tested as individual genes, 13 mouse-identified genes were associated with human anxiety phenotypes, suggesting an overlap of individual genes contributing to both mouse models of anxiety-like behaviors and human anxiety traits. When genes were tested as sets, …
When tested as individual genes, 13 mouse-identified genes were associated with human anxiety phenotypes, suggesting an overlap of in …
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
Hou X, Chen TH, Koga S, Bredenberg JM, Faroqi AH, Delenclos M, Bu G, Wszolek ZK, Carr JA, Ross OA, McLean PJ, Murray ME, Dickson DW, Fiesel FC, Springer W. Hou X, et al. Brain Pathol. 2023 May 31:e13175. doi: 10.1111/bpa.13175. Online ahead of print. Brain Pathol. 2023. PMID: 37259617
Accumulating evidence suggests that mitochondrial dysfunction and impairments of the autophagic-lysosomal system can contribute to the deposition of alphasyn, which in turn may interfere with health and function of these organelles in a potentially vicious cycle. ...We fur …
Accumulating evidence suggests that mitochondrial dysfunction and impairments of the autophagic-lysosomal system can contribute to the depos …
Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions.
Ngo D, Magaña AJ, Tran T, Sklenicka J, Phan K, Eykholt B, Jimenez V, Ramirez MS, Tolmasky ME. Ngo D, et al. Pharmaceuticals (Basel). 2023 Feb 3;16(2):236. doi: 10.3390/ph16020236. Pharmaceuticals (Basel). 2023. PMID: 37259383 Free PMC article.
Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the …
Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists o …
In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [11C]OCM-44 and [18F]OCM-50 in Non-Human Primates.
Smart K, Zheng MQ, Holden D, Felchner Z, Zhang L, Han Y, Ropchan J, Carson RE, Vasdev N, Huang Y. Smart K, et al. Pharmaceuticals (Basel). 2023 Jan 28;16(2):194. doi: 10.3390/ph16020194. Pharmaceuticals (Basel). 2023. PMID: 37259346 Free PMC article.
The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [(11)C]OCM-44 and [(18)F]OCM-50, in non-human primates to assess their potential for clinical translation. ...
The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [(11)C]OCM-44 and [(18)F]OCM-50, in …
Minimal residual disease predicts outcomes in KMT2A-rearranged but not KMT2A-germline infant acute lymphoblastic leukemia: Report from Children's Oncology Group study AALL0631.
Faulk KE, Kairalla JA, Dreyer ZE, Carroll AJ, Heerema NA, Devidas M, Carroll WL, Raetz EA, Loh ML, Hunger SP, Borowitz M, Wang C, Guest E, Brown PA. Faulk KE, et al. Pediatr Blood Cancer. 2023 May 31:e30467. doi: 10.1002/pbc.30467. Online ahead of print. Pediatr Blood Cancer. 2023. PMID: 37259259
We measured minimal residual disease (MRD) by multiparameter flow cytometry at three time points (TP) in 117 infants with KMT2A (lysine [K]-specific methyltransferase 2A)-rearranged and 58 with KMT2A-germline acute lymphoblastic leukemia (ALL) on Children's Oncology Group …
We measured minimal residual disease (MRD) by multiparameter flow cytometry at three time points (TP) in 117 infants with KMT2A (lysine [K]- …
Facilitation of team-based care to improve HTN management and outcomes: a protocol for a randomized stepped wedge trial.
Shelley DR, Brown D, Cleland CM, Pham-Singer H, Zein D, Chang JE, Wu WY. Shelley DR, et al. BMC Health Serv Res. 2023 May 31;23(1):560. doi: 10.1186/s12913-023-09533-1. BMC Health Serv Res. 2023. PMID: 37259081 Free PMC article.
Team-based care (TBC) is an evidence-based strategy for improving blood pressure (BP) management and control. TBC is defined as the provision of health services by at least two health professionals "who work collaboratively with patients and their caregivers …
Team-based care (TBC) is an evidence-based strategy for improving blood pressure (BP) management and control. TBC is defined as the provisio …
SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity.
Zhong H, Lu W, Tang Y, Wiel C, Wei Y, Cao J, Riedlinger G, Papagiannakopoulos T, Guo JY, Bergo MO, Kang Y, Ganesan S, Sabaawy HE, Pine SR. Zhong H, et al. Oncogene. 2023 May 31. doi: 10.1038/s41388-023-02715-5. Online ahead of print. Oncogene. 2023. PMID: 37258742
These data were validated by flow cytometry, gene expression, RT-qPCR, and immunohistochemistry analyses in Kras(G12D)-driven murine LUAD, then confirmed by interrogating bulk and single-cell gene expression repertoires and immunohistochemistry in human LUAD. Notably, SOX9 …
These data were validated by flow cytometry, gene expression, RT-qPCR, and immunohistochemistry analyses in Kras(G12D)-driven murine LUAD, t …
Early life stress in male mice blunts responsiveness in a translationally-relevant reward task.
Hisey EE, Fritsch EL, Newman EL, Ressler KJ, Kangas BD, Carlezon WA Jr. Hisey EE, et al. Neuropsychopharmacology. 2023 May 31. doi: 10.1038/s41386-023-01610-7. Online ahead of print. Neuropsychopharmacology. 2023. PMID: 37258714
Understanding the signs of ELS, including those associated with psychiatric illness, will enable improved treatment and prevention. Here, we developed a novel procedure to model human ELS in mice and identify translationally-relevant biomarkers of mood and anxiety disorder …
Understanding the signs of ELS, including those associated with psychiatric illness, will enable improved treatment and prevention. Here, we …
Portable, high speed blood flow measurements enabled by long wavelength, interferometric diffuse correlation spectroscopy (LW-iDCS).
Robinson MB, Renna M, Ozana N, Martin AN, Otic N, Carp SA, Franceschini MA. Robinson MB, et al. Sci Rep. 2023 May 31;13(1):8803. doi: 10.1038/s41598-023-36074-8. Sci Rep. 2023. PMID: 37258644 Free PMC article.
Through direct comparison with long wavelength DCS based on superconducting nanowire single photon detectors, we demonstrate an approximate 5 improvement in SNR over a single channel of LW-DCS in the measured blood flow signals in human subjects. We show equivalence of ext …
Through direct comparison with long wavelength DCS based on superconducting nanowire single photon detectors, we demonstrate an approximate …
The digital transformation of surgery.
Marwaha JS, Raza MM, Kvedar JC. Marwaha JS, et al. NPJ Digit Med. 2023 May 31;6(1):103. doi: 10.1038/s41746-023-00846-3. NPJ Digit Med. 2023. PMID: 37258642 Free PMC article.
Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography.
Park JC, Persidina O, Balasubramanian G, Nguyen T, Pradeep A, Hetling JR, McAnany JJ. Park JC, et al. Sci Rep. 2023 May 31;13(1):8860. doi: 10.1038/s41598-023-35996-7. Sci Rep. 2023. PMID: 37258636 Free PMC article.
Dark-adapted ERGs were recorded for flash luminances of - 3.0 to 1.5 log cd-s-m(-2); a- and b-wave amplitude and implicit time (IT) were calculated from these responses. ...
Dark-adapted ERGs were recorded for flash luminances of - 3.0 to 1.5 log cd-s-m(-2); a- and b-wave amplitude and implicit time (IT) w …
Predicting body mass index in early childhood using data from the first 1000 days.
Cheng ER, Cengiz AY, Miled ZB. Cheng ER, et al. Sci Rep. 2023 May 31;13(1):8781. doi: 10.1038/s41598-023-35935-6. Sci Rep. 2023. PMID: 37258628 Free PMC article.
When tested on the remaining 20% of the patients, the models predicted children's BMI with high accuracy (mean average error [standard deviation] = 0.96[0.02] at 30-36 months, 0.98 [0.03] at 36-42 months, and 1.00 [0.02] at 42-48 months) and can be used to support clinical …
When tested on the remaining 20% of the patients, the models predicted children's BMI with high accuracy (mean average error [standar …
Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults.
Nannini DR, Zheng Y, Joyce BT, Kim K, Gao T, Wang J, Jacobs DR, Schreiner PJ, Yaffe K, Greenland P, Lloyd-Jones DM, Hou L. Nannini DR, et al. Mol Psychiatry. 2023 May 31. doi: 10.1038/s41380-023-02106-y. Online ahead of print. Mol Psychiatry. 2023. PMID: 37258616
These results provide novel insights into the role marijuana has on the epigenome and related health conditions....
These results provide novel insights into the role marijuana has on the epigenome and related health conditions....
Markers and makers of NKT17 cells.
Liman N, Park JH. Liman N, et al. Exp Mol Med. 2023 Jun 1. doi: 10.1038/s12276-023-01015-y. Online ahead of print. Exp Mol Med. 2023. PMID: 37258582 Review.
Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research.
Shaw JA, Meiring M, Allies D, Cruywagen L, Fisher TL, Kasavan K, Roos K, Botha SM, MacDonald C, Hiemstra AM, Simon D, van Rensburg I, Flinn M, Shabangu A, Kuivaniemi H, Tromp G, Malherbe ST, Walzl G, du Plessis N; Stellenbosch University Immunology Research Group Bronchoalveolar Lavage Study Consortium (SU IRG BAL Study Consortium). Shaw JA, et al. Sci Rep. 2023 May 31;13(1):8859. doi: 10.1038/s41598-023-35723-2. Sci Rep. 2023. PMID: 37258565 Free PMC article.
Indications of musculoskeletal health in deceased male individuals with lower-limb amputations: comparison to non-amputee and diabetic controls.
Finco MG, Finnerty C, Ngo W, Menegaz RA. Finco MG, et al. Sci Rep. 2023 May 31;13(1):8838. doi: 10.1038/s41598-023-34773-w. Sci Rep. 2023. PMID: 37258530 Free PMC article.
Individuals with lower-limb amputations, many of whom have type 2 diabetes, experience impaired musculoskeletal health. This study: (1) compared residual and intact limbs of diabetic and non-diabetic post-mortem individuals with amputation to identify structures vulnerable …
Individuals with lower-limb amputations, many of whom have type 2 diabetes, experience impaired musculoskeletal health. This study: ( …
Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial.
Corbin KD, Carnero EA, Dirks B, Igudesman D, Yi F, Marcus A, Davis TL, Pratley RE, Rittmann BE, Krajmalnik-Brown R, Smith SR. Corbin KD, et al. Nat Commun. 2023 May 31;14(1):3161. doi: 10.1038/s41467-023-38778-x. Nat Commun. 2023. PMID: 37258525 Free PMC article. Clinical Trial.
The gut microbiome is emerging as a key modulator of human energy balance. Prior studies in humans lacked the environmental and dietary controls and precision required to quantitatively evaluate the contributions of the gut microbiome. Using a Microbiome Enhancer Diet (MBD …
The gut microbiome is emerging as a key modulator of human energy balance. Prior studies in humans lacked the environmental and dieta …
Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline.
Mehta NH, Zhou L, Li Y, McIntire LB, Nordvig A, Butler T, de Leon M, Chiang GC. Mehta NH, et al. Sci Rep. 2023 May 31;13(1):8847. doi: 10.1038/s41598-023-34012-2. Sci Rep. 2023. PMID: 37258519 Free PMC article.
Neuroinflammation is believed to be a key process in Alzheimer's disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratios (LMR) have been proposed to be useful peripheral markers of inflammation. ...We further evaluated asso …
Neuroinflammation is believed to be a key process in Alzheimer's disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (N …
Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization.
Prior JT, Limbert VM, Horowitz RM, D'Souza SJ, Bachnak L, Godwin MS, Bauer DL, Harrell JE, Morici LA, Taylor JJ, McLachlan JB. Prior JT, et al. NPJ Vaccines. 2023 May 31;8(1):80. doi: 10.1038/s41541-023-00677-z. NPJ Vaccines. 2023. PMID: 37258506 Free PMC article.
Although most pathogens infect the human body via mucosal surfaces, very few injectable vaccines can specifically target immune cells to these tissues where their effector functions would be most desirable. ...Further, we found that the transcription factor Batf3 was impor …
Although most pathogens infect the human body via mucosal surfaces, very few injectable vaccines can specifically target immune cells …
Stress-induced metabolic exchanges between complementary bacterial types underly a dynamic mechanism of inter-species stress resistance.
Amarnath K, Narla AV, Pontrelli S, Dong J, Reddan J, Taylor BR, Caglar T, Schwartzman J, Sauer U, Cordero OX, Hwa T. Amarnath K, et al. Nat Commun. 2023 May 31;14(1):3165. doi: 10.1038/s41467-023-38913-8. Nat Commun. 2023. PMID: 37258505 Free PMC article.
Cultures of such communities progress through distinct phases of growth-dilution cycles, comprising of exponential growth, acidification-triggered growth arrest, collaborative deacidification, and growth recovery, with each phase involving different combinations of physiological …
Cultures of such communities progress through distinct phases of growth-dilution cycles, comprising of exponential growth, acidification-tri …
Emerging functions of thrombospondin-1 in immunity.
Kaur S, Roberts DD. Kaur S, et al. Semin Cell Dev Biol. 2023 May 29:S1084-9521(23)00117-9. doi: 10.1016/j.semcdb.2023.05.008. Online ahead of print. Semin Cell Dev Biol. 2023. PMID: 37258315 Review.
Risky drinking and other drug use in adults with chronic conditions in the United States: differential associations by race/ethnicity.
Cook WK, Kerr WC, Tam CC, Li L. Cook WK, et al. Alcohol Alcohol. 2023 Jun 1:agad024. doi: 10.1093/alcalc/agad024. Online ahead of print. Alcohol Alcohol. 2023. PMID: 37258041
Co-use of multiple drugs may prolong or increase heavy drinking, even for individuals with health conditions adversely affected by it. Patterns of alcohol and drug use may vary across racial/ethnic groups, with differential implications for health. ...Multiple logis …
Co-use of multiple drugs may prolong or increase heavy drinking, even for individuals with health conditions adversely affected by it …
Cell surface marker-based capture of neoantigen-reactive CD8+ T-cell receptors from metastatic tumor digests.
Chatani PD, Lowery FJ, Parikh NB, Hitscherich KJ, Yossef R, Hill V, Gartner JJ, Paria B, Florentin M, Ray S, Bera A, Parkhust M, Robbins P, Krishna S, Rosenberg SA. Chatani PD, et al. J Immunother Cancer. 2023 May;11(5):e006264. doi: 10.1136/jitc-2022-006264. J Immunother Cancer. 2023. PMID: 37258038 Free article.
As the genetic engineering of T cells with tumor-reactive T-cell receptors (TCRs) comes to the forefront of clinical investigation, the rapid, scalable, and cost-effective detection of patient-specific neoantigen-reactive TIL remains a top priority. METHODS: We analyzed the singl …
As the genetic engineering of T cells with tumor-reactive T-cell receptors (TCRs) comes to the forefront of clinical investigation, the rapi …
Multidisciplinary Critical Care Management of Electrical Storm: JACC State-of-the-Art Review.
Jentzer JC, Noseworthy PA, Kashou AH, May AM, Chrispin J, Kabra R, Arps K, Blumer V, Tisdale JE, Solomon MA; American College of Cardiology Critical Care Cardiology and Electrophysiology Sections. Jentzer JC, et al. J Am Coll Cardiol. 2023 Jun 6;81(22):2189-2206. doi: 10.1016/j.jacc.2023.03.424. J Am Coll Cardiol. 2023. PMID: 37257955 Review.
Kindergarten conduct problems are associated with monetized outcomes in adolescence and adulthood.
Goulter N, Hur YS, Jones DE, Godwin J, McMahon RJ, Dodge KA, Lansford JE, Lochman JE, Bates JE, Pettit GS, Crowley DM. Goulter N, et al. J Child Psychol Psychiatry. 2023 May 31. doi: 10.1111/jcpp.13837. Online ahead of print. J Child Psychol Psychiatry. 2023. PMID: 37257941
BACKGROUND: Across several sites in the United States, we examined whether kindergarten conduct problems among mostly population-representative samples of children were associated with increased criminal and related (criminal + lost offender productivity + victim; d …
BACKGROUND: Across several sites in the United States, we examined whether kindergarten conduct problems among mostly populati …
Developing electronic clinical quality measures to assess the cancer diagnostic process.
Murphy DR, Zimolzak AJ, Upadhyay DK, Wei L, Jolly P, Offner A, Sittig DF, Korukonda S, Rekha RM, Singh H. Murphy DR, et al. J Am Med Inform Assoc. 2023 May 31:ocad089. doi: 10.1093/jamia/ocad089. Online ahead of print. J Am Med Inform Assoc. 2023. PMID: 37257883
The 2 eCQMs quantified rates of red-flag follow-up in CRC and lung cancer using electronic health record data repositories at 2 large healthcare systems. Each measure used clinical data to identify abnormal results, evidence of appropriate follow-up, and exclusions that si …
The 2 eCQMs quantified rates of red-flag follow-up in CRC and lung cancer using electronic health record data repositories at 2 large …
Hip resurfacing arthroplasty as an alternative to total hip arthroplasty in patients aged under 40 years.
Ramkumar PN, Shaikh HJF, Woo JJ, Haeberle HS, Pang M, Brooks PJ. Ramkumar PN, et al. Bone Jt Open. 2023 Jun 1;4(6):408-415. doi: 10.1302/2633-1462.46.BJO-2023-0015.R1. Bone Jt Open. 2023. PMID: 37257853 Free PMC article.
AIMS: The aims of the study were to report for a cohort aged younger than 40 years: 1) indications for HRA; 2) patient-reported outcomes in terms of the modified Harris Hip Score (HHS); 3) dislocation rate; and 4) revision rate. METHODS: This retrospective analysis identif …
AIMS: The aims of the study were to report for a cohort aged younger than 40 years: 1) indications for HRA; 2) patient-reported outcomes in …
Assessing geographic disparities in mental health research participation.
Shora L, Friberg E, Park LT, DeGennaro R, Hinton I, Zarate CA Jr. Shora L, et al. Contemp Clin Trials. 2023 May 29:107244. doi: 10.1016/j.cct.2023.107244. Online ahead of print. Contemp Clin Trials. 2023. PMID: 37257724
BACKGROUND: Large geographic health disparities are well-documented within the U.S. Although approximately 60 million Americans-or roughly 20% of the total U.S. population-live in rural areas, rural residents may be less likely to participate in …
BACKGROUND: Large geographic health disparities are well-documented within the U.S. Although approximately 60 million A …
Gracillin relieves pulmonary fibrosis by suppressing the STAT3 axis.
Xie M, Yang L, Cheng J, Qu H, Gu Y, Ding C, Xu X, Zhao C, Huang X, Wang L. Xie M, et al. J Ethnopharmacol. 2023 May 29:116704. doi: 10.1016/j.jep.2023.116704. Online ahead of print. J Ethnopharmacol. 2023. PMID: 37257706
Gracillin also suppressed TGF-beta1-induced increases in ECM deposition biomarkers, including COL1A1, fibronectin, alpha-SMA, N-cad and vimentin, and repressed migration in NIH-3T3 cells. Additionally, gracillin suppressed the phosphorylation, nuclear translocation and tra …
Gracillin also suppressed TGF-beta1-induced increases in ECM deposition biomarkers, including COL1A1, fibronectin, alpha-SMA, N-cad and vime …
Investigating the NRAS 5' UTR as a target for small molecules.
Balaratnam S, Torrey ZR, Calabrese DR, Banco MT, Yazdani K, Liang X, Fullenkamp CR, Seshadri S, Holewinski RJ, Andresson T, Ferré-D'Amaré AR, Incarnato D, Schneekloth JS Jr. Balaratnam S, et al. Cell Chem Biol. 2023 May 26:S2451-9456(23)00140-X. doi: 10.1016/j.chembiol.2023.05.004. Online ahead of print. Cell Chem Biol. 2023. PMID: 37257453
Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults.
Beydoun MA, Noren Hooten N, Beydoun HA, Weiss J, Maldonado AI, Katzel LI, Davatzikos C, Gullapalli RP, Seliger SL, Erus G, Evans MK, Zonderman AB, Waldstein SR. Beydoun MA, et al. Neurobiol Aging. 2023 May 2;129:28-40. doi: 10.1016/j.neurobiolaging.2023.04.013. Online ahead of print. Neurobiol Aging. 2023. PMID: 37257406
Stress and the autonomic nervous system.
Goldstein DS. Goldstein DS. Auton Neurosci. 2023 May 10;247:103096. doi: 10.1016/j.autneu.2023.103096. Online ahead of print. Auton Neurosci. 2023. PMID: 37257231 No abstract available.
Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome.
Baghdassarian H, Blackstone SA, Clay OS, Philips R, Matthiasardottir B, Nehrebecky M, Hua VK, McVicar R, Liu Y, Tucker SM, Randazzo D, Deuitch N, Rosenzweig S, Mark A, Sasik R, Fisch KM, Pimpale Chavan P, Eren E, Watts NR, Ma CA, Gadina M, Schwartz DM, Sanyal A, Werner G, Murdock DR, Horita N, Chowdhury S, Dimmock D, Jepsen K, Remmers EF, Goldbach-Mansky R, Gahl WA, O'Shea JJ, Milner JD, Lewis NE, Chang J, Kastner DL, Torok K, Oda H, Putnam CD, Broderick L. Baghdassarian H, et al. N Engl J Med. 2023 May 31. doi: 10.1056/NEJMoa2202318. Online ahead of print. N Engl J Med. 2023. PMID: 37256972
Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.
O'Sullivan ED, Mylonas KJ, Xin C, Baird DP, Carvalho C, Docherty MH, Campbell R, Matchett KP, Waddell SH, Walker AD, Gallagher KM, Jia S, Leung S, Laird A, Wilflingseder J, Willi M, Reck M, Finnie S, Pisco A, Gordon-Keylock S, Medvinsky A, Boulter L, Henderson NC, Kirschner K, Chandra T, Conway BR, Hughes J, Denby L, Bonventre JV, Ferenbach DA. O'Sullivan ED, et al. Sci Transl Med. 2023 May 31;15(698):eabn0736. doi: 10.1126/scitranslmed.abn0736. Epub 2023 May 31. Sci Transl Med. 2023. PMID: 37256934
Using single-cell-resolution transcriptomic analysis, we identified an "inflammatory" proximal tubular epithelial (iPT) population contributing to TNF- and nuclear factor kappaB (NF-kappaB)-induced IHH production in vivo. TNF-induced Ubiquitin D (Ubd) expression was observed in …
Using single-cell-resolution transcriptomic analysis, we identified an "inflammatory" proximal tubular epithelial (iPT) population contribut …
An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa.
Koeppen K, Hampton TH, Barnaby R, Roche C, Gerber SA, Goo YA, Cho BK, Vermilyea DM, Hogan DA, Stanton BA. Koeppen K, et al. Am J Physiol Lung Cell Mol Physiol. 2023 May 31. doi: 10.1152/ajplung.00150.2022. Online ahead of print. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37256658
We previously demonstrated that extracellular vesicles (EVs) secreted by primary human airway epithelial cells (AEC) delivermiRNA let-7b-5p to P. aeruginosa to suppress biofilm formation and increase sensitivity to beta-lactam antibiotics. ...
We previously demonstrated that extracellular vesicles (EVs) secreted by primary human airway epithelial cells (AEC) delivermiRNA let …
Effect of Perioperative Palliative Care on Health-Related Quality of Life Among Patients Undergoing Surgery for Cancer: A Randomized Clinical Trial.
Aslakson RA, Rickerson E, Fahy B, Waterman B, Siden R, Colborn K, Smith S, Verano M, Lira I, Hollahan C, Siddiqi A, Johnson K, Chandrashekaran S, Harris E, Nudotor R, Baker J, Heidari SN, Poultsides G, Conca-Cheng AM, Cook Chapman A, Lessios AS, Holdsworth LM, Gustin J, Ejaz A, Pawlik T, Miller J, Morris AM, Tulsky JA, Lorenz K, Temel JS, Smith TJ, Johnston F. Aslakson RA, et al. JAMA Netw Open. 2023 May 1;6(5):e2314660. doi: 10.1001/jamanetworkopen.2023.14660. JAMA Netw Open. 2023. PMID: 37256623 Free PMC article. Clinical Trial.
MAIN OUTCOMES AND MEASURES: The primary outcome of the trial was patient-reported health-related quality of life at 3 months following the operation. ...There was no significant difference between study arms in outcomes at 3 months following the operation in patient-report …
MAIN OUTCOMES AND MEASURES: The primary outcome of the trial was patient-reported health-related quality of life at 3 months followin …
Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial: A Secondary Analysis of a Randomized Clinical Trial.
Gentle SJ, Rysavy MA, Li L, Laughon MM, Patel RM, Jensen EA, Hintz S, Ambalavanan N, Carlo WA, Watterberg K; National Institute of Child Health and Human Development Neonatal Research Network. Gentle SJ, et al. JAMA Netw Open. 2023 May 1;6(5):e2315315. doi: 10.1001/jamanetworkopen.2023.15315. JAMA Netw Open. 2023. PMID: 37256621 Free PMC article. Clinical Trial.
IMPORTANCE: Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN …
IMPORTANCE: Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevel …
Late-onset Cognitive Impairment and Modifiable Risk Factors in Adult Childhood Cancer Survivors.
Phillips NS, Stratton KL, Williams AM, Ahles T, Ness KK, Cohen HJ, Edelstein K, Yasui Y, Oeffinger K, Chow EJ, Howell RM, Robison LL, Armstrong GT, Leisenring WM, Krull KR. Phillips NS, et al. JAMA Netw Open. 2023 May 1;6(5):e2316077. doi: 10.1001/jamanetworkopen.2023.16077. JAMA Netw Open. 2023. PMID: 37256617 Free PMC article.
EXPOSURES: Cancer treatment exposures were abstracted from medical records. Chronic health conditions were graded using Common Terminology Criteria for Adverse Events version 4.03. ...Relative risks (RRs) and 95% CIs were used to estimate associations of neurocognitive imp …
EXPOSURES: Cancer treatment exposures were abstracted from medical records. Chronic health conditions were graded using Common Termin …
Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: a longitudinal multicenter data pooling analysis.
de Ruiter MB, Deardorff RL, Blommaert J, Chen BT, Dumas JA, Schagen SB, Sunaert S, Wang L, Cimprich B, Peltier S, Dittus K, Newhouse PA, Silverman DH, Schroyen G, Deprez S, Saykin AJ, McDonald BC. de Ruiter MB, et al. Brain Imaging Behav. 2023 May 31. doi: 10.1007/s11682-023-00781-7. Online ahead of print. Brain Imaging Behav. 2023. PMID: 37256494
Childhood Obesity and Cardiovascular Disease Risk.
Chung ST, Krenek A, Magge SN. Chung ST, et al. Curr Atheroscler Rep. 2023 May 31:1-11. doi: 10.1007/s11883-023-01111-4. Online ahead of print. Curr Atheroscler Rep. 2023. PMID: 37256483 Free PMC article. Review.
While the link between childhood obesity and cardiovascular disease is established, this contemporary review summarizes recent and novel advances in this field that elucidate the mechanisms and impact of this public health issue. RECENT FINDINGS: The review highlights the …
While the link between childhood obesity and cardiovascular disease is established, this contemporary review summarizes recent and novel adv …
Global Mental Health: Where We Are and Where We Are Going.
Moitra M, Owens S, Hailemariam M, Wilson KS, Mensa-Kwao A, Gonese G, Kamamia CK, White B, Young DM, Collins PY. Moitra M, et al. Curr Psychiatry Rep. 2023 May 31:1-11. doi: 10.1007/s11920-023-01426-8. Online ahead of print. Curr Psychiatry Rep. 2023. PMID: 37256471 Free PMC article. Review.
PURPOSE OF REVIEW: To summarize recent findings in global mental health along several domains including socioeconomic determinants, inequities, funding, and inclusion in global mental health research and practice. ...Inequities also exist in funding for global menta …
PURPOSE OF REVIEW: To summarize recent findings in global mental health along several domains including socioeconomic determinants, i …
Comparative arrhythmia patterns among patients on tyrosine kinase inhibitors.
Wei C, Fazal M, Loh A, Kapoor R, Gomez SE, Shah S, Rogers AJ, Narayan SM, Wang PJ, Witteles RM, Perino AC, Cheng P, Rhee JW, Baykaner T. Wei C, et al. J Interv Card Electrophysiol. 2023 May 31. doi: 10.1007/s10840-023-01575-z. Online ahead of print. J Interv Card Electrophysiol. 2023. PMID: 37256462
Limited studies have shown an association between treatment-limiting arrhythmias and TKI, particularly ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor. We sought to comprehensively assess the arrhythmia burden in patients receiving ibrutinib vs non-BTK TKI vs non-TKI …
Limited studies have shown an association between treatment-limiting arrhythmias and TKI, particularly ibrutinib, a Bruton's tyrosine …
"Bone-SASP" in Skeletal Aging.
Fang CL, Liu B, Wan M. Fang CL, et al. Calcif Tissue Int. 2023 May 31:1-15. doi: 10.1007/s00223-023-01100-4. Online ahead of print. Calcif Tissue Int. 2023. PMID: 37256358 Free PMC article. Review.
Suspension culture on microcarriers and as aggregates enables expansion and differentiation of pluripotent stem cells (PSCs).
Vallabhaneni H, Shah T, Shah P, Hursh DA. Vallabhaneni H, et al. Cytotherapy. 2023 May 29:S1465-3249(23)00933-7. doi: 10.1016/j.jcyt.2023.05.002. Online ahead of print. Cytotherapy. 2023. PMID: 37256241
BACKGROUND AIMS: Human pluripotent stem cells (PSCs) hold a great promise for promoting regenerative medical therapies due to their ability to generate multiple mature cell types and for their high expansion potential. ...
BACKGROUND AIMS: Human pluripotent stem cells (PSCs) hold a great promise for promoting regenerative medical therapies due to their a …
A randomized, placebo-controlled, double-blinded mechanistic clinical trial using endotoxin to evaluate the relationship between insomnia, inflammation, and affective disturbance on pain in older adults: A protocol for the sleep and Healthy Aging Research for pain (SHARE-P) study.
DuPont CM, Olmstead R, Reid MJ, Hamilton KR, Campbell CM, Finan PH, Sadeghi N, Castillo D, Irwin MR, Smith MT. DuPont CM, et al. Brain Behav Immun Health. 2023 May 19;30:100642. doi: 10.1016/j.bbih.2023.100642. eCollection 2023 Jul. Brain Behav Immun Health. 2023. PMID: 37256193 Free PMC article.
In doing so, it aims to extend the current literature by: (1) including older adults, (2) investigating insomnia as a potential risk factor for chronic pain, (3) evaluating the role of endotoxin-induced affective disturbances on pain sensitivity, and (4) assessing sex differences …
In doing so, it aims to extend the current literature by: (1) including older adults, (2) investigating insomnia as a potential risk factor …
Adverse events with risankizumab in the real world: postmarketing pharmacovigilance assessment of the FDA adverse event reporting system.
Shu Y, Chen J, Ding Y, Zhang Q. Shu Y, et al. Front Immunol. 2023 May 15;14:1169735. doi: 10.3389/fimmu.2023.1169735. eCollection 2023. Front Immunol. 2023. PMID: 37256136 Free PMC article.
BACKGROUND: Risankizumab, a humanized IgG1 monoclonal antibody that selectively inhibits IL-23, is currently approved for the treatment of moderate-to-severe plaque psoriasis and Crohn's disease. The real-world safety study of risankizumab in a large- sample population is …
BACKGROUND: Risankizumab, a humanized IgG1 monoclonal antibody that selectively inhibits IL-23, is currently approved for the treatment of m …
Mendability Index: A new metric for estimating the effort required for manually editing auto-segmentations of objects of interest.
He D, Udupa JK, Tong Y, Torigian DA. He D, et al. Proc SPIE Int Soc Opt Eng. 2023 Feb;12469:1246905. doi: 10.1117/12.2654421. Epub 2023 Apr 10. Proc SPIE Int Soc Opt Eng. 2023. PMID: 37256076 Free PMC article.
However, by comparing the predicted segmentation with the ground truth, currently widely-used metrics usually focus on the overlapping area (Dice Coefficient) or the most severe shifting of the boundary (Hausdorff Distance), which seem inconsistent with human reader behavi …
However, by comparing the predicted segmentation with the ground truth, currently widely-used metrics usually focus on the overlapping area …
An evaluation of nutrition, culinary, and production interventions using African indigenous vegetables on nutrition security among smallholder farmers in Western Kenya.
Merchant EV, Odendo M, Maiyo N, Govindasamy R, Morin XK, Simon JE, Hoffman DJ. Merchant EV, et al. Front Nutr. 2023 May 15;10:1154423. doi: 10.3389/fnut.2023.1154423. eCollection 2023. Front Nutr. 2023. PMID: 37255934 Free PMC article.
The impact evaluation was analyzed by Household Hunger Scale (HHS), Women's Dietary Diversity Score (WDDS), AIV consumption frequency, and AIV market availability. Statistical tests included descriptive statistics (means and frequencies), paired t-test, McNemar's …
The impact evaluation was analyzed by Household Hunger Scale (HHS), Women's Dietary Diversity Score (WDDS), AIV consumption fr …
Counterfactual and Factual Reasoning over Hypergraphs for Interpretable Clinical Predictions on EHR.
Xu R, Yu Y, Zhang C, Ali MK, Ho JC, Yang C. Xu R, et al. Proc Mach Learn Res. 2022 Nov;193:259-278. Proc Mach Learn Res. 2022. PMID: 37255863 Free PMC article.
Electronic Health Record modeling is crucial for digital medicine. However, existing models ignore higher-order interactions among medical codes and their causal relations towards downstream clinical predictions. ...
Electronic Health Record modeling is crucial for digital medicine. However, existing models ignore higher-order interactions among me …
A Review of Hormone and Non-Hormonal Therapy Options for the Treatment of Menopause.
Madsen TE, Sobel T, Negash S, Shrout Allen T, Stefanick ML, Manson JE, Allison M. Madsen TE, et al. Int J Womens Health. 2023 May 25;15:825-836. doi: 10.2147/IJWH.S379808. eCollection 2023. Int J Womens Health. 2023. PMID: 37255734 Free PMC article. Review.
Understanding the role of both menopausal hormone therapy (MHT) along with non-hormonal options for the treatment of vasomotor symptoms, sleep disruption, and genitourinary symptoms after menopause is critical to the health of women during middle and later life. Recent upd …
Understanding the role of both menopausal hormone therapy (MHT) along with non-hormonal options for the treatment of vasomotor symptoms, sle …
Removing or Only Moving a Barrier? Screening Applications with US Medical Licensing Examination Step 2CK Instead of Step 1 May Benefit Women but Not Underrepresented Minorities in Orthopaedics.
Huffman WH, Ayotte SR, Johnson MA, Cipriano CA. Huffman WH, et al. JB JS Open Access. 2023 May 30;8(2):e22.00140. doi: 10.2106/JBJS.OA.22.00140. eCollection 2023 Apr-Jun. JB JS Open Access. 2023. PMID: 37255670 Free PMC article. Review.
METHODS: We reviewed all 855 Electronic Residency Application Service applications submitted to the University of Pennsylvania's orthopaedic surgery residency program in the 2020-2021 cycle. ...Step 1 scores but not Step 2CK scores were lower for applicants who were women …
METHODS: We reviewed all 855 Electronic Residency Application Service applications submitted to the University of Pennsylvania's orth …
Pediatric Swine Model of Methicillin-Resistant Staphylococcus aureus Sepsis-Induced Coagulopathy, Disseminated Microvascular Thrombosis, and Organ Injuries.
Nguyen TC, Marini JC, Guillory B, Valladolid-Brown C, Martinez-Vargas M, Subramanyam D, Cohen D, Cirlos SC, Lam F, Stoll B, Didelija IC, Vonderohe C, Orellana R, Saini A, Pradhan S, Bashir D, Desai MS, Flores S, Virk M, Tcharmtchi H, Navaei A, Kaplan S, Lamberth L, Hulten KG, Scull BP, Allen CE, Akcan-Arikan A, Vijayan KV, Cruz MA. Nguyen TC, et al. Crit Care Explor. 2023 May 26;5(6):e0916. doi: 10.1097/CCE.0000000000000916. eCollection 2023 Jun. Crit Care Explor. 2023. PMID: 37255626 Free PMC article.
Large animal models replicating sepsis-induced coagulopathy are needed to test new therapeutics before human clinical trials. HYPOTHESIS: Our objective is to develop a pediatric sepsis-induced coagulopathy swine model that last 70 hours. METHODS AND MODELS: Ten 3 weeks old …
Large animal models replicating sepsis-induced coagulopathy are needed to test new therapeutics before human clinical trials. HYPOTHE …
Exploring human biology with N-of-1 clinical trials.
Schork NJ, Beaulieu-Jones B, Liang WS, Smalley S, Goetz LH. Schork NJ, et al. Camb Prism Precis Med. 2023;1:e12. doi: 10.1017/pcm.2022.15. Epub 2023 Jan 10. Camb Prism Precis Med. 2023. PMID: 37255593 Free PMC article.
Studies on humans that exploit contemporary data-intensive, high-throughput 'omic' assay technologies, such as genomics, transcriptomics, proteomics and metabolomics, have unequivocally revealed that humans differ greatly at the molecular level. These differences, which are compo …
Studies on humans that exploit contemporary data-intensive, high-throughput 'omic' assay technologies, such as genomics, transcriptomics, pr …
Arts for Whose Sake? Arts Course-taking and Math Achievement in US High Schools.
Freeman DM, Shifrer D. Freeman DM, et al. Sociol Perspect. 2023 Apr;66(2):226-245. doi: 10.1177/07311214221124537. Epub 2022 Sep 24. Sociol Perspect. 2023. PMID: 37255527 Free PMC article.
Math achievement in U.S. high schools is a consistent predictor of educational attainment. ...
Math achievement in U.S. high schools is a consistent predictor of educational attainment. ...
Critical Role of Viral Protein Hexon in Hypervirulent Fowl Adenovirus Serotype-4-Induced Autophagy by Interaction with BAG3 and Promotion of Viral Replication in LMH Cells.
Li W, You G, Haiyilati A, Wang H, Jiao H, Wang Y, Gao L, Cao H, Li X, Zheng SJ. Li W, et al. J Virol. 2023 May 31:e0028423. doi: 10.1128/jvi.00284-23. Online ahead of print. J Virol. 2023. PMID: 37255472
Hepatitis-pericardial syndrome (HHS) is an acute highly infectious avian disease caused by fowl adenovirus serotype 4 (FAdV-4), characterized by fulminant hepatitis and hydropericardium in broilers. ...Thus, these findings reveal that HPFAdV-4 hexon interacts with the host …
Hepatitis-pericardial syndrome (HHS) is an acute highly infectious avian disease caused by fowl adenovirus serotype 4 (FAdV-4), chara …
Acute Repair of Meniscus Root Tear Partially Restores Joint Displacements as Measured With Magnetic Resonance Images and Loading in a Cadaveric Porcine Knee.
Meadows KD, Peloquin JM, Markhali MI, Zgonis MH, Schaer TP, Mauck RL, Elliott DM. Meadows KD, et al. J Biomech Eng. 2023 Aug 1;145(8):081002. doi: 10.1115/1.4062524. J Biomech Eng. 2023. PMID: 37255448
Methods from this study can be applied to assess altered joint kinematics following human knee injuries and evaluate repair strategies aimed to restore joint kinematics....
Methods from this study can be applied to assess altered joint kinematics following human knee injuries and evaluate repair strategie …
Changing Severity and Epidemiology of Adults Hospitalized With Coronavirus Disease 2019 (COVID-19) in the United States After Introduction of COVID-19 Vaccines, March 2021-August 2022.
Kojima N, Adams K, Self WH, Gaglani M, McNeal T, Ghamande S, Steingrub JS, Shapiro NI, Duggal A, Busse LW, Prekker ME, Peltan ID, Brown SM, Hager DN, Ali H, Gong MN, Mohamed A, Exline MC, Khan A, Wilson JG, Qadir N, Chang SY, Ginde AA, Withers CA, Mohr NM, Mallow C, Martin ET, Lauring AS, Johnson NJ, Casey JD, Stubblefield WB, Gibbs KW, Kwon JH, Baughman A, Chappell JD, Hart KW, Jones ID, Rhoads JP, Swan SA, Womack KN, Zhu Y, Surie D, McMorrow ML, Patel MM, Tenforde MW; Investigating Respiratory Viruses in the Acutely Ill (IVY) Network. Kojima N, et al. Clin Infect Dis. 2023 May 31:ciad276. doi: 10.1093/cid/ciad276. Online ahead of print. Clin Infect Dis. 2023. PMID: 37255285
INTRODUCTION: Understanding the changing epidemiology of adults hospitalized with coronavirus disease 2019 (COVID-19) informs research priorities and public health policies. METHODS: Among adults (18 years) hospitalized with laboratory-confirmed, acute COVID-19 between 11 …
INTRODUCTION: Understanding the changing epidemiology of adults hospitalized with coronavirus disease 2019 (COVID-19) informs research prior …
The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss.
Nobles CJ, Mendola P, Mumford SL, Silver RM, Kim K, Perkins NJ, Schisterman EF. Nobles CJ, et al. Epidemiology. 2023 May 30. doi: 10.1097/EDE.0000000000001631. Online ahead of print. Epidemiology. 2023. PMID: 37255247
BACKGROUND: While redox stress likely plays an important role in reproductive health, the utility of peripheral biomarkers of oxidative stress, such as isoprostanes, during the periconception period remains underexplored. We evaluated the relationship between isoprostanes …
BACKGROUND: While redox stress likely plays an important role in reproductive health, the utility of peripheral biomarkers of oxidati …
Preferences for Rectal STI Sample Collection and Sexual Behaviors Among Adolescent and Young Adult Women Accessing Primary Care Services.
Woods HE, Schuh AM, Gaydos CA, Fenchel M, Kowalczyk Mullins TL, Conard LAE, Manabe YC, Widdice LE. Woods HE, et al. Sex Transm Dis. 2023 May 29. doi: 10.1097/OLQ.0000000000001835. Online ahead of print. Sex Transm Dis. 2023. PMID: 37255238
Differences were tested using chi-square and two-sided Fisher's exact test. RESULTS: Of 110 cisgender women (aged 14-22 years) enrolled, the average age was 18.4 years (SD 1.7); 83% reported a history of extragenital contact; 22% reported history of receptive anal intercou …
Differences were tested using chi-square and two-sided Fisher's exact test. RESULTS: Of 110 cisgender women (aged 14-22 years) enroll …
Association of race and in-hospital outcomes following acute pulmonary embolism: A retrospective cohort study.
Sullivan AE, Barbery CE, Holder T, Green CL, Patel MR, Thomas KL, Jones WS. Sullivan AE, et al. Clin Cardiol. 2023 May 31. doi: 10.1002/clc.24055. Online ahead of print. Clin Cardiol. 2023. PMID: 37255216
BACKGROUND: Racial disparities in health care are well established, with Black patients frequently experiencing the most significant consequences of this inequality. Acute pulmonary embolism (PE) is increasing in incidence and an important cause of morbidity and mortality …
BACKGROUND: Racial disparities in health care are well established, with Black patients frequently experiencing the most significant …