Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2018 2
2019 3
2020 3
2021 10
2022 7
2023 3
2024 4
2025 10

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

36 results

Results by year

Filters applied: . Clear all
Page 1
An intranasal adjuvanted, recombinant influenza A/H5 vaccine primes against diverse H5N1 clades: a phase I trial.
Deming ME, Toapanta FR, Pasetti M, Golding H, Khurana S, Hamouda T, Fattom A, Liang Y, Tennant SM, McGilvray MF, Bernal PJ, Oshinsky JJ, Datta S, Booth JP, Coughlan L, Neuzil KM, Costley CD, Kotloff KL, Sztein MB, Ortiz JR; rH5 Writing Group. Deming ME, et al. Nat Commun. 2025 Nov 6;16(1):9321. doi: 10.1038/s41467-025-64686-3. Nat Commun. 2025. PMID: 41198655 Free PMC article. Clinical Trial.
Mucosal influenza vaccines may provide improved protection against infection and transmission, but their development is hindered by absence of immune correlates of protection. Here, we report a randomized, controlled phase I trial of a recombinant influenza A/H5 (A/Indones …
Mucosal influenza vaccines may provide improved protection against infection and transmission, but their development is hindered by a …
Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis.
Liesenfeld O, Arora S, Aufderheide TP, Clements CM, DeVos E, Fischer M, Giamarellos-Bourboulis EJ, House S, Humphries RL, Gill JK, Liu E, Mace SE, May L, Michelson E, Osborn TM, Panacek E, Rothman RE, Self WH, Smithline HA, Steingrub J, Van Heukelom P, Weissman A, Wilson M, Wolk DM, Wright DW, Buturovic L, Hasin-Brumshtein Y, Damaraju N, Lu C, Shak JR, Whitfield NN, Khatri P, Sweeney TE, Shapiro NI. Liesenfeld O, et al. Nat Med. 2025 Sep 30. doi: 10.1038/s41591-025-03933-y. Online ahead of print. Nat Med. 2025. PMID: 41028541
A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 Helicase.
Doijen J, Xie J, Marsili S, Bains T, Mann MK, Abeywickrema P, Van den Broeck N, Permann C, Langer T, Ibis G, Mattelaer CA, Harvey J, van Raalte S, Fino R, Pande V, Peeters D, Patrick A, Van Damme E, van Vlijmen H, Van Loock M, Jacoby E. Doijen J, et al. J Comput Chem. 2025 Sep 5;46(23):e70201. doi: 10.1002/jcc.70201. J Comput Chem. 2025. PMID: 40910569 Free PMC article.
The compounds, discovered using a novel fragment-based pharmacophore virtual screening workflow named FragmentScout, enable the advancement of novel antiviral agents. FragmentScout uses publicly accessible structural data of the SARS-CoV-2 NSP13 helicase, which was previou …
The compounds, discovered using a novel fragment-based pharmacophore virtual screening workflow named FragmentScout, enable the advanceme …
APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence.
Xie J, Chen DG, Chour W, Ng RH, Zhang R, Yuan D, Choi J, McKasson M, Troisch P, Smith B, Jones L, Webster A, Rasheed Y, Li S, Edmark R, Hong S, Murray KM, Logue JK, Franko NM, Lausted CG, Piening B, Algren H, Wallick J, Magis AT, Watanabe K, Mease P, Greenberg PD, Chu H, Goldman JD, Su Y, Heath JR. Xie J, et al. Nat Commun. 2025 Feb 6;16(1):1402. doi: 10.1038/s41467-025-56659-3. Nat Commun. 2025. PMID: 39915487 Free PMC article.
Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost.
Zhang B, Fong Y, Dang L, Fintzi J, Chen S, Wang J, Rouphael NG, Branche AR, Diemert DJ, Falsey AR, Graciaa DS, Baden LR, Frey SE, Whitaker JA, Little SJ, Kamidani S, Walter EB, Novak RM, Rupp R, Jackson LA, Yu C, Magaret CA, Molitor C, Borate B, Busch S, Benkeser D, Netzl A, Smith DJ, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub SM, Goepfert PA, Fusco DN, Atmar RL, Posavad CM, Mu J, Makowski M, Makhene MK, Nayak SU, Roberts PC, Gilbert PB, Follmann D; Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team. Zhang B, et al. Nat Commun. 2025 Jan 17;16(1):759. doi: 10.1038/s41467-025-55931-w. Nat Commun. 2025. PMID: 39824819 Free PMC article. Clinical Trial.
A Rapid Virus-Free Method for Producing Influenza HA Immunogen Needed for Preparation of Influenza Vaccine Potency Antisera Reagents.
Odin M, Schmeisser F, Soto J, Weir JP. Odin M, et al. Influenza Other Respir Viruses. 2024 Oct;18(10):e70024. doi: 10.1111/irv.70024. Influenza Other Respir Viruses. 2024. PMID: 39440693 Free PMC article.
CONCLUSIONS: The results demonstrate that rHA produced from a simple mammalian cell transfection method can be used to generate HA antibody suitable for use in the influenza vaccine SRID potency assay and suggest a practical means by which an extensive library of pandemic reagent …
CONCLUSIONS: The results demonstrate that rHA produced from a simple mammalian cell transfection method can be used to generate HA antibody …
Patient outcomes by baseline pathogen resistance phenotype and genotype in CERTAIN-1, a Phase 3 study of cefepime-taniborbactam versus meropenem in adults with complicated urinary tract infection.
Moeck G, Gasink LB, Mendes RE, Woosley LN, Dorr M, Chen H, Wagenlehner FM, Henkel T, McGovern PC. Moeck G, et al. Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0023624. doi: 10.1128/aac.00236-24. Epub 2024 May 23. Antimicrob Agents Chemother. 2024. PMID: 38780262 Free PMC article. Clinical Trial.
A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects.
Hernández-Mitre MP, Wallis SC, Morgan EE, Dudley MN, Loutit JS, Griffith DC, Roberts JA. Hernández-Mitre MP, et al. Antimicrob Agents Chemother. 2024 Jan 10;68(1):e0109923. doi: 10.1128/aac.01099-23. Epub 2023 Dec 7. Antimicrob Agents Chemother. 2024. PMID: 38059635 Free PMC article. Clinical Trial.
Dose proportionality and accumulation of cis- and trans-ceftibuten were observed. These results support the ongoing development of ceftibuten at doses up to 800 mg twice-daily. (The study was registered at ClinicalTrials.gov under the identifier NCT03939429.)....
Dose proportionality and accumulation of cis- and trans-ceftibuten were observed. These results support the ongoing development of ce …
Multi-center clinical evaluation of the Panther Fusion SARS-CoV-2/Flu A/B/RSV assay in nasopharyngeal swab specimens from symptomatic individuals.
Sasidharan A, Selvarangan R, Konrad K, Faron ML, Shakir SM, Hillyard D, McCall RK, McHardy IH, Goldberg DC, Dunn JJ, Greninger AL, Lansang C, Bogh R, Remillard CV. Sasidharan A, et al. J Clin Microbiol. 2023 Nov 21;61(11):e0082723. doi: 10.1128/jcm.00827-23. Epub 2023 Oct 30. J Clin Microbiol. 2023. PMID: 37902331 Free PMC article.
New boronate drugs and evolving NDM-mediated beta-lactam resistance.
Lomovskaya O, Tsivkovski R, Totrov M, Dressel D, Castanheira M, Dudley M. Lomovskaya O, et al. Antimicrob Agents Chemother. 2023 Sep 19;67(9):e0057923. doi: 10.1128/aac.00579-23. Epub 2023 Aug 31. Antimicrob Agents Chemother. 2023. PMID: 37650617 Free PMC article.
Taniborbactam and xeruborbactam are dual serine-/metallo-beta-lactamase inhibitors (BLIs) based on a cyclic boronic acid pharmacophore that undergo clinical development. Recent report demonstrated that New Delhi metallo-beta-lactamase (NDM)-9 (differs from NDM-1 by a singl …
Taniborbactam and xeruborbactam are dual serine-/metallo-beta-lactamase inhibitors (BLIs) based on a cyclic boronic acid pharmacophore that …
Flu@home: the Comparative Accuracy of an At-Home Influenza Rapid Diagnostic Test Using a Prepositioned Test Kit, Mobile App, Mail-in Reference Sample, and Symptom-Based Testing Trigger.
Kotnik JH, Cooper S, Smedinghoff S, Gade P, Scherer K, Maier M, Juusola J, Ramirez E, Naraghi-Arani P, Lyon V, Lutz B, Thompson M. Kotnik JH, et al. J Clin Microbiol. 2022 Mar 16;60(3):e0207021. doi: 10.1128/JCM.02070-21. Epub 2022 Feb 2. J Clin Microbiol. 2022. PMID: 35107302 Free PMC article. Review.
A convenience sample of 5,229 individuals who were engaged with an on-line health research platform were prospectively recruited throughout the United States. "Flu@home" test kits containing a QuickVue RDT and reference sample collection and shipping materials were preposi …
A convenience sample of 5,229 individuals who were engaged with an on-line health research platform were prospectively recruited thro …
Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye.
Watson RJ, Tree J, Fotheringham SA, Hall Y, Dong X, Steeds K, Gouriet J, Salguero FJ, Burton C, Pitman J, Easterbrook L, Richards KS, Burton J, Bewley K, Bruce C, Hiscox JA, Carroll MW, Funnell SGP. Watson RJ, et al. J Virol. 2021 Nov 23;95(24):e0083321. doi: 10.1128/JVI.00833-21. Epub 2021 Sep 29. J Virol. 2021. PMID: 34586862 Free PMC article.
Filoviruses cause high-consequence infections with limited approved medical countermeasures (MCMs). MCM development is dependent upon well-characterized animal models for the assessment of antiviral agents and vaccines. ...
Filoviruses cause high-consequence infections with limited approved medical countermeasures (MCMs). MCM development is dependent upon …
Identification and Characterization of Defective Viral Genomes in Ebola Virus-Infected Rhesus Macaques.
Johnson RI, Boczkowska B, Alfson K, Weary T, Menzie H, Delgado J, Rodriguez G, Carrion R Jr, Griffiths A. Johnson RI, et al. J Virol. 2021 Aug 10;95(17):e0071421. doi: 10.1128/JVI.00714-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34160256 Free PMC article.
IMPORTANCE The study of filovirus pathogenesis is critical for understanding the consequences of infection and for the development of strategies to ameliorate future outbreaks. Defective viral genomes (DVGs) have been detected during EBOV infections in vitro; however, thei …
IMPORTANCE The study of filovirus pathogenesis is critical for understanding the consequences of infection and for the development of …
Adjuvanted recombinant hemagglutinin H7 vaccine to highly pathogenic influenza A(H7N9) elicits high and sustained antibody responses in healthy adults.
Oshansky CM, King J, Lu D, Zhou J, Pavetto C, Horwith G, Biscardi K, Nguyen B, Treanor JJ, Chen LM, Jepson B; BPI17002 Study Coordination Team; Bright RA, Johnson RA, Cioce V, Donis RO. Oshansky CM, et al. NPJ Vaccines. 2021 Mar 19;6(1):41. doi: 10.1038/s41541-021-00287-7. NPJ Vaccines. 2021. PMID: 33741987 Free PMC article.
An unprecedented number of human infections with avian influenza A(H7N9) in the fifth epidemic wave during the winter of 2016-2017 in China and their antigenic divergence from the viruses that emerged in 2013 prompted development of updated vaccines for pandemic preparedne …
An unprecedented number of human infections with avian influenza A(H7N9) in the fifth epidemic wave during the winter of 2016-2017 in China …
H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets.
de Jonge J, van Dijken H, de Heij F, Spijkers S, Mouthaan J, de Jong R, Roholl P, Adami EA, Akamatsu MA, Ho PL, Brunner L, Collin N, Friede M, Ferreira JA, Luytjes W. de Jonge J, et al. NPJ Vaccines. 2020 May 11;5(1):38. doi: 10.1038/s41541-020-0187-4. eCollection 2020. NPJ Vaccines. 2020. PMID: 32411401 Free PMC article.
An immune-cell signature of bacterial sepsis.
Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. Reyes M, et al. Nat Med. 2020 Mar;26(3):333-340. doi: 10.1038/s41591-020-0752-4. Epub 2020 Feb 17. Nat Med. 2020. PMID: 32066974 Free PMC article.
Tetanus, diphtheria, and pertussis vaccine (Tdap) in pregnancy and risk of major birth defects in the offspring.
Kerr SM, Van Bennekom CM, Mitchell AA. Kerr SM, et al. Birth Defects Res. 2020 Mar;112(5):393-403. doi: 10.1002/bdr2.1642. Epub 2020 Jan 5. Birth Defects Res. 2020. PMID: 31903700
BACKGROUND: The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy to protect newborns against pertussis infection in the months prior to their primary pertussis vaccination. Although research on the safety of …
BACKGROUND: The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy to protect …
Transcriptomic responses in mouse blood during the first week after in vivo gamma irradiation.
Paul S, Kleiman NJ, Amundson SA. Paul S, et al. Sci Rep. 2019 Dec 4;9(1):18364. doi: 10.1038/s41598-019-54780-0. Sci Rep. 2019. PMID: 31797975 Free PMC article.
Due to limitations of available human models for development of gene expression based radiation biodosimetry, many such studies have made use of mouse models. ...
Due to limitations of available human models for development of gene expression based radiation biodosimetry, many such studies have …