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2014 2
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2018 1
2019 170
2020 281
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2023 588
2024 1328
2025 1377
2026 434

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Page 1
A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development.
Abberbock E, Ridnik M, Stévant I, Weiss R, Bamberger C, Ziv Lhermann S, Lubman M, Yao YM, Afek A, Poulat F, Gonen N. Abberbock E, et al. Nat Commun. 2026 Apr 9;17(1):3186. doi: 10.1038/s41467-026-71328-9. Nat Commun. 2026. PMID: 41957362 Free article.
Mammalian sex determination is governed by two mutually antagonistic genetic programs that must be precisely balanced. Activation of Sox9 initiates testis development, while its repression is essential for ovarian fate. ...
Mammalian sex determination is governed by two mutually antagonistic genetic programs that must be precisely balanced. Activation of …
Balanced polymorphism underlies long-standing adaptation for seasonal camouflage in the least weasel.
Miranda I, Ruivo R, Farelo L, Alvarenga M, Borowski Z, Elmeros M, Kalthoff DC, Merilä J, Müller JP, Schley L, Suchentrunk F, Sundell J, Rodrigues M, Santos-Reis M, Fernandes CR, Zub K, Good JM, Mills LS, Castro LFC, Dalén L, Melo-Ferreira J. Miranda I, et al. Commun Biol. 2026 Apr 10. doi: 10.1038/s42003-026-09937-9. Online ahead of print. Commun Biol. 2026. PMID: 41957296 Free article.
Amphibole reaction rims record shear during magma ascent.
Wallace PA, Birnbaum J, De Angelis SH, Mariani E, Larsen J, Kendrick JE, Christopher TE, Cole PD, Lamur A, Lavallée Y. Wallace PA, et al. Nat Commun. 2026 Apr 9. doi: 10.1038/s41467-026-71477-x. Online ahead of print. Nat Commun. 2026. PMID: 41957029 Free article.
With EBSD-derived crystal orientations now shown to capture both thermodynamic and mechanical histories, amphibole reaction rims emerge as four-dimensional petrological recorders, sensitive to pressure, temperature, composition and strain (P-T-X-epsilon), providing a powerful uni …
With EBSD-derived crystal orientations now shown to capture both thermodynamic and mechanical histories, amphibole reaction rims emerge as f …
Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries.
Barone C, Quattrini G, Muratore A, Anselmi G, Park Y, Mehmood NT, Morganti E, Orsenigo R, Timóteo-Ferreira F, Cazzola A, Patelli A, Milanesi T, Nesti B, Soares-da-Silva F, Nicholls M, Zambelli G, Mauri M, Bombelli S, De Marco S, D'Aliberti D, Spinelli S, Bonalume V, Domingues A, Naghavi Alhosseini M, Sala G, Colonna A, D'Errico E, D'Orlando C, Bianchi C, Perego RA, Meneveri R, Cumano A, Brunelli S, De Bruijn MFTR, Ditadi A, Fantin A, Piazza R, Azzoni E. Barone C, et al. Nat Cardiovasc Res. 2026 Apr 8. doi: 10.1038/s44161-026-00793-8. Online ahead of print. Nat Cardiovasc Res. 2026. PMID: 41951931
A guide to using embedded ethics in human stem-cell-based embryo model research.
Bentzen HB, Gaillard M, Nachman I, Reumann D, Gadegaard N, David L, Lanner F, Moris N, Pasque V, Rivron N, Sozen B, Isasi R, Krauss S, Veenvliet JV. Bentzen HB, et al. Nat Cell Biol. 2026 Apr 8. doi: 10.1038/s41556-026-01909-9. Online ahead of print. Nat Cell Biol. 2026. PMID: 41951755 Review.
Human stem-cell-based embryo models (hSCBEMs) offer unprecedented opportunities for basic and translational research. However, the rapid pace of scientific developments in the field challenges the slower, traditional modes of ethics evaluation. To facilitate responsible …
Human stem-cell-based embryo models (hSCBEMs) offer unprecedented opportunities for basic and translational research. However, the ra …
Morally relevant features warranting ethical oversight in human stem cell-based embryo models.
Moris N, Martinez Arias A, Pera M, Rivron N, Sermon K, de Graeff N. Moris N, et al. Nat Cell Biol. 2026 Apr 8. doi: 10.1038/s41556-026-01881-4. Online ahead of print. Nat Cell Biol. 2026. PMID: 41951754 Review.
Recent guidelines have argued for case-by-case evaluation of stem cell-based embryo model research but it is still unclear what exactly such oversight should consider. Here we argue that effective review requires the identification of a set of attributes by which to evalua …
Recent guidelines have argued for case-by-case evaluation of stem cell-based embryo model research but it is still unclear what exact …
From theory to practice: Re-identification Challenge to test imaging data pseudonymization effectiveness.
Catalán Flores R, Gómez-Rico Junquero I, Jiménez Gómez P, Gomes Carvalho J, Mazzetti S, Martínez Martínez R, Segrelles Quilis JD, Lozano Lloret P, Galiana-Bordera A, Bargellini I, Regge D, França M, Martí-Bonmatí L. Catalán Flores R, et al. Sci Data. 2026 Apr 8. doi: 10.1038/s41597-026-06857-5. Online ahead of print. Sci Data. 2026. PMID: 41951636 Free article.
Respiration as a dynamic modulator of sensory sampling.
Chalas N, Saltafossi M, Berther T, Balestrieri E, Abbasi O, Kluger DS. Chalas N, et al. Nat Commun. 2026 Apr 7;17(1):3261. doi: 10.1038/s41467-026-71604-8. Nat Commun. 2026. PMID: 41946728 Free PMC article.
Recruitment of Mre11 to recombination sites during meiosis.
Priyadarshini P, Survi M, El Yazidi Mouloud W, Bohn R, Ballet S, Hunter N, Volkov AN, Claeys Bouuaert C. Priyadarshini P, et al. Nat Commun. 2026 Apr 7. doi: 10.1038/s41467-026-71310-5. Online ahead of print. Nat Commun. 2026. PMID: 41946721 Free article.
During meiosis in budding yeast, MRX is also required for Spo11-mediated programmed DSB formation to initiate homologous recombination. Recruitment of Mre11 to meiotic DSB sites depends on Rec114-Mei4 and Mer2, proposed to organize the DSB machinery via biomolecular conden …
During meiosis in budding yeast, MRX is also required for Spo11-mediated programmed DSB formation to initiate homologous recombinatio …
Direct observations of atmospheric oxidized mercury speciation in polar areas.
Jokinen T, Gómez Martín JC, Feinberg A, Mahajan AS, Plane JMC, Ulises Acuña A, Cuevas C, Dávalos JZ, Quéléver LLJ, Laurila T, Beck I, Schmale J, Junninen H, Sipilä M, Kulmala M, Petäjä T, Saiz-Lopez A. Jokinen T, et al. Nat Commun. 2026 Apr 7;17(1):3160. doi: 10.1038/s41467-026-71146-z. Nat Commun. 2026. PMID: 41946705 Free PMC article.
Charged molecular glue discovery enabled by targeted degron display.
Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Słabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS. Zhuang Z, et al. Nat Chem Biol. 2026 Apr 6. doi: 10.1038/s41589-026-02182-5. Online ahead of print. Nat Chem Biol. 2026. PMID: 41942733
Social media users experience more political hostility in less economically equal and less democratic societies.
Bor A, Marie A, Pradella L, Petersen MB. Bor A, et al. Nat Hum Behav. 2026 Apr 3. doi: 10.1038/s41562-026-02432-5. Online ahead of print. Nat Hum Behav. 2026. PMID: 41933213
In particular, the relationship between online hostility and the broader sociopolitical context has received less attention, in part because of limited research outside Western countries. Here we report results from observational data collected through quota-sampled online …
In particular, the relationship between online hostility and the broader sociopolitical context has received less attention, in part because …
Unbinned contigs expand known diversity in the global microbiome.
Prasoodanan Pk V, Maistrenko OM, Fullam A, Mende DR, Kartal E, Coelho LP, Spang A, Bork P, Schmidt TSB. Prasoodanan Pk V, et al. Nat Microbiol. 2026 Apr 3. doi: 10.1038/s41564-026-02314-6. Online ahead of print. Nat Microbiol. 2026. PMID: 41933201
A family of endonucleases blocks nanotube-mediated plasmid exchange.
Gopu V, Bhattacharya S, Bejerano-Sagie M, Zhuang M, Nevo Y, Yakovian O, Shraiteh B, Ravins M, Guria MK, Kahan T, Maček B, Rosenshine I, Ben-Yehuda S. Gopu V, et al. Nat Microbiol. 2026 Apr;11(4):960-975. doi: 10.1038/s41564-026-02293-8. Epub 2026 Apr 3. Nat Microbiol. 2026. PMID: 41933200
Population discontinuity in the Paris Basin linked to evidence of the Neolithic decline.
Seersholm FV, Ramsøe A, Cao J, Chambon P, Sjögren KG, McColl H, Demeter F, Gaunitz C, Vinner L, Stenderup J, Scorrano G, Fyfe R, Price TD, Mortensen MF, Krüger S, Dehn T, Hansen SI, Vesterdorf K, Korneliussen TS, Allentoft ME, Kristiansen K, Salanova L, Willerslev E, Sikora M. Seersholm FV, et al. Nat Ecol Evol. 2026 Apr 3. doi: 10.1038/s41559-026-03027-z. Online ahead of print. Nat Ecol Evol. 2026. PMID: 41933041
ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas.
Hennequart M, Mervant L, Stockis J, Coomes J, Zarou MM, Gerard L, Tevel V, Migeot V, Pilley SE, Lee Y, Driscoll PC, Legrave NM, Labuschagne CF, Zani F, Uribe AH, Ferreira RMM, Cheung EC, Malanchi I, MacRae JI, Maddocks ODK, Halim TYF, Vousden KH. Hennequart M, et al. Nat Metab. 2026 Apr 1. doi: 10.1038/s42255-026-01456-5. Online ahead of print. Nat Metab. 2026. PMID: 41922744
The genetic architecture of an allosteric hormone receptor.
Stammnitz MR, Lehner B. Stammnitz MR, et al. Nat Commun. 2026 Apr 1. doi: 10.1038/s41467-026-70341-2. Online ahead of print. Nat Commun. 2026. PMID: 41922352 Free article.
Rare single amino acid substitutions confer phenotypic innovation, including inverted and band-stop activation functions. Our data demonstrate the feasibility of dose-response profile quantification at massive scale and reveal the remarkable evolutionary malleability of a …
Rare single amino acid substitutions confer phenotypic innovation, including inverted and band-stop activation functions. Our data de …
Single-event fast neutron time-of-flight spectrometry with a petawatt-laser-driven neutron source.
Millán-Callado MA, Scheuren S, Alejo A, Benlliure J, Beyer R, Cowan TE, Fernández B, Griesmayer E, Junghans AR, Kohl J, Kroll F, Metzkes-Ng J, Prencipe I, Quesada JM, Rehwald M, Rödel C, Rodríguez-González T, Schramm U, Roth M, Štefaníková R, Urlass S, Weiss C, Zeil K, Ziegler T, Guerrero C. Millán-Callado MA, et al. Nat Commun. 2026 Apr 1;17(1):3154. doi: 10.1038/s41467-026-70312-7. Nat Commun. 2026. PMID: 41922328 Free PMC article.
Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.
Hop PJ, Kooyman M, Kenna BJ, Zwamborn RAJ, van Eijk KR, Wang Y, van Dijk CH, Bekema E, van Rheenen W, Beele P, van Vugt JJFA; Project MinE ALS sequencing Consortium; NYGC ALS Consortium; FALS sequencing Consortium; GTAC Consortium; Khleifat AA, Iacoangeli A, Cooper-Knock J, Smith BN, Topp S, van der Kooi AJ, Fominykh V, Drory V, Lerner Y, Shovman Y, Rowe DB, Williams KL, McLaughlin RL, Hurt J, Huang Y, Chen CY, Tsai E, Runz H, Aronica E, Groen EJN, van Es MA, Pasterkamp RJ, Farhan SMK, Garton FC, McRae AF, McCombe PA, Henderson RD, Fan D, Šlachtová L, Høyer H, Nishimura AL, Cauchi RJ, Brylev L, Rogelj B, Koritnik B, Zidar J, Salas T, Mora Pardina JS, Gotkine M, Povedano M, Corcia P, Vourc'h P, Couratier P, Weber M, Kiernan MC, Pamphlett R, Blair IP, de Carvalho M, Başak NA, Ingre C, Andersen PM, Zinman L, Rogaeva E, MacKenzie IR, Dupre N, Rouleau GA, Traynor BJ, Ticozzi N, Chiò A, Silani V, Hardiman O, Phatnani H, Harms MB, Dalgard CL, Glass JD, Landers JE, Van Damme P, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A, van den Berg LH, Kenna KP, Veldink JH. Hop PJ, et al. Nat Genet. 2026 Mar 31. doi: 10.1038/s41588-026-02535-9. Online ahead of print. Nat Genet. 2026. PMID: 41917433
Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells.
van Zanten ES, Loehrer EA, van Meurs JBJ, Narcisi R, Gribnau JH, Poot RA, Adams HHH. van Zanten ES, et al. Eur J Hum Genet. 2026 Mar 31. doi: 10.1038/s41431-026-02071-4. Online ahead of print. Eur J Hum Genet. 2026. PMID: 41917264 Review.
Induced pluripotent stem cells (iPSCs) have emerged as a powerful tool in biomedical research, enabling the study of cellular function and early disease mechanisms within patient-specific genetic contexts. ...
Induced pluripotent stem cells (iPSCs) have emerged as a powerful tool in biomedical research, enabling the study of cellular functio …
Structural insights into the Thermus thermophilus type IV pilus machinery assembling two distinct pili.
Neuhaus A, McLaren M, Isupov MN, Gaines M, Buzzard E, Sikora M, Hanus C, Daum B, Averhoff B, Gold VAM. Neuhaus A, et al. Commun Biol. 2026 Mar 31;9(1):474. doi: 10.1038/s42003-026-09762-0. Commun Biol. 2026. PMID: 41917195 Free PMC article.
Integration of the filament structures with our hypothetical model of the assembly machinery offers a framework for further dissecting T4P architecture and biogenesis....
Integration of the filament structures with our hypothetical model of the assembly machinery offers a framework for further dissectin …
Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still's disease.
Veiga R, De Vuyst L, Poulet C, Neumann J, Bücken L, Prezzemolo T, Willemsen M, Vanderschueren S, Matthys P, Chabaane E, Fléron M, Cobraiville G, Baiwir D, Mazzucchelli G; Immunome Project Consortium for Autoinflammatory Disorders (ImmunAID); Fautrel B, Wouters C, De Seny D, Humblet-Baron S, Liston A. Veiga R, et al. Nat Commun. 2026 Apr 1. doi: 10.1038/s41467-026-70895-1. Online ahead of print. Nat Commun. 2026. PMID: 41917006 Free article.
Future scenarios for British biodiversity under climate and land-use change.
Cooke R, Burton VJ, Brown C, Harrower CA, White SM, Huntingford C, Dunford-Brown R, Fox R, Harrison PA, Hui C, Massimino D, Purvis A, Robinson EL, Rodger J, Isaac NJB, Bullock JM. Cooke R, et al. Nat Commun. 2026 Mar 31;17(1):2704. doi: 10.1038/s41467-026-70064-4. Nat Commun. 2026. PMID: 41916970 Free PMC article.
Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies.
Leitão E, Santini A, Cogne B, Essid M, Athanasiadou M, LaFlamme CW, Marijon P, Bernard V, Jousselin K, Chatron N, Barcia G, Keren B, Mignot C, Charles P, Besnard T, Paluch R, de Sainte Agathe JM, Almanza Fuerte EP, Sengupta S, Milh M, Ramond F, Allan T, An I, Araujo C, Arpin S, Austin-Tse C, Auvin S, Baer S, Bahi-Buisson N, Bak M, Barth M, Baulac S, Bednarek-Weirauch N, Begemann M, Bennett MF, Bensabath U, Bézieau S, Bhouri R, Biehler M, Hammer TB, Bogoin J, Bonanno E, Boussion S, Bris C, Brosseau-Beauvir A, Bruel AL, Briand-Suleau A, Buratti J, Celse T, Chambon P, Chemaly N, Chesneau B, Colin E, Colmard M, Colson C, Conrad S, Courtin T, Creveaux I, Cullier AC, Dang LT, de Saint Martin A, de Vanssay de Blavous Legendre C, Demeer B, Denommé-Pichon AS, Diekhoff P, DiTroia S, Doco-Fenzy M, Dubourg C, Dubucs C, Ducreux S, Dufour L, Duquet R, Durand B, El Chehadeh S, Elbracht M, Faivre L, Faoucher M, Faudet A, Forlani S, Fradin M, Gaignard P, Ganne B, Garde A, Géraud J, Gill D, Goldenberg A, Grabli D, Grisel C, Gueden S, Gueguen P, Guerrot AM, Guichet A, Haack TB, Härting N, Häusler MG, Heide S, Herget T, Héron B, Héron D, Herwig J, Heulin M, Holling T, Houdayer C, Isidor B, Jacquette … See abstract for full author list ➔ Leitão E, et al. Nat Genet. 2026 Mar 30. doi: 10.1038/s41588-026-02547-5. Online ahead of print. Nat Genet. 2026. PMID: 41912934
Antagonistic SMAD2/3 control of TIMP-1, VEGF-A, and hypoxia signaling in myofibroblasts shapes histotype-specific angiogenesis in lung cancer.
Díaz-Valdivia N, Duch P, Ikemori R, Parker AL, Arshakyan M, Llorente A, Bernardo A, Rodríguez-Rojas J, Carrasco JL, Park D, Sahai E, Fillat C, Juan M, Nadal E, Reguart N, Radisky DC, Casanovas O, Alcaraz J. Díaz-Valdivia N, et al. Cell Death Dis. 2026 Mar 30. doi: 10.1038/s41419-026-08677-2. Online ahead of print. Cell Death Dis. 2026. PMID: 41912498 Free article.
In addition, these findings provide a biological framework for understanding the histotype-dependent patterns of dissemination, immune evasion, and response to anti-angiogenic therapies in NSCLC....
In addition, these findings provide a biological framework for understanding the histotype-dependent patterns of dissemination, immun …
Magnetosensation - the unsolved mystery.
Lam BYK, Malkemper EP. Lam BYK, et al. Physiol Rev. 2026 Mar 28. doi: 10.1152/physrev.00032.2025. Online ahead of print. Physiol Rev. 2026. PMID: 41902539 Review.
Eco-sustainable magnetoresistive sensors towards disposable magnetoelectronics.
Guo L, Xu R, Das PT, Oliveros-Mata ES, Peng X, Pylypovskyi OV, Hübner R, Ganss F, Wang X, Li Y, Gepp S, Zabila Y, Bao X, Li S, Zhang Q, Veremchuk I, Janićijević Ž, Baraban L, Voigt C, Mosch S, Gutfleisch O, Li RW, Makarov D. Guo L, et al. Nat Commun. 2026 Mar 27;17(1):3034. doi: 10.1038/s41467-026-71077-9. Nat Commun. 2026. PMID: 41896215 Free PMC article.
Prediction of strong Cu(I)-He interaction at open metal sites enables isotope-selective helium adsorption.
Dongmo EG, Das S, Moncada F, Riemer-Wulf T, Heine T. Dongmo EG, et al. Nat Commun. 2026 Mar 26;17(1):2952. doi: 10.1038/s41467-026-70901-6. Nat Commun. 2026. PMID: 41888520 Free PMC article.
Then, we establish a predictive model to study larger systems hosting Cu(I) sites, including crown ethers, zeolites and metal-organic frameworks (MOFs). The strong Cu(I)-He interaction induces significant differences in the (4)He/(3)He zero-point energies, allowing predict …
Then, we establish a predictive model to study larger systems hosting Cu(I) sites, including crown ethers, zeolites and metal-organic fra
Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli.
Gladstone RA, Pesonen M, Pöntinen AK, Mäklin T, MacAlasdair N, Thorpe H, Shao Y, Mallawaarachchi S, Arredondo-Alonso S, Parcell BJ, Turnbull JD, Tonkin-Hill G, Johnsen PJ, Samuelsen Ø, Thomson NR, Lawley T, Corander J. Gladstone RA, et al. Nat Microbiol. 2026 Mar 25. doi: 10.1038/s41564-026-02283-w. Online ahead of print. Nat Microbiol. 2026. PMID: 41882299
Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice.
Rumpler M, van Mierlo G, Vinten KT, Giner MP, Christen S, Hayat F, Makarov MV, Gardeux V, Russeil J, Schomakers BV, van Gijn L, Hashimi H, Steiner C, Giroud-Gerbetant J, Joffraud M, Sanchez Garcia JL, Moco S, Migaud ME, Houtkooper RH, Deplancke B, Canto C. Rumpler M, et al. Nat Commun. 2026 Mar 25. doi: 10.1038/s41467-026-70965-4. Online ahead of print. Nat Commun. 2026. PMID: 41882002 Free article.
Enhanced dynamic risk stratification of smoldering multiple myeloma.
Chabrun F, Schwartz DE, Gentile S, Mai EK, Gupta TR, Perry J, Cordas Dos Santos DM, Hielscher T, Werly A, Schmidt SK, Theodorakakou F, Fotiou D, Liacos CI, Kanellias N, Gisbert NC, Martin-Sanchez E, Termini R, Waldschmidt J, Chavda SJ, Ainley L, Da Vià MC, De Magistris C, Pettine L, Timonian MA, Alberge JB, Patel V, Costello P, Tobia C, Phan S, Lamb J, Silverio MT, Davis M, O'Donnell EK, Marinac CR, Nadeem O, Bolli N, Yong K, Kortüm KM, Einsele H, Mateos MV, Kumar S, San-Miguel JF, Paiva B, Kastritis E, Dimopoulos MA, Raab MS, Trippa L, Ghobrial IM. Chabrun F, et al. Nat Med. 2026 Mar 24. doi: 10.1038/s41591-026-04304-x. Online ahead of print. Nat Med. 2026. PMID: 41876650
Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France.
Noraz R, Chauvey L, Wagner S, Estrada O, Wales N, Bonnaire E, Cabanis M, Derreumaux M, Figueiral I, Hallavant C, Marinval P, Matterne V, Ros J, Rovira N, Tillier M, Bovagne M, Chausserie-Laprée J, Nicolas C, Daveau I, Delassus D, Gailledrat E, Ginouvez O, Houix B, Jung C, Kuchler P, Leroux L, Macario R, Marlière E, Pasqualini M, Piques G, Pomaredes H, Robert J, Roms C, Roth-Zehner M, Scrinzi M, Taras-Thomas M, Torres Costa J, Besnard G, Terral JF, Bacilieri R, Bouby L, Orlando L. Noraz R, et al. Nat Commun. 2026 Mar 24;17(1):2494. doi: 10.1038/s41467-026-70166-z. Nat Commun. 2026. PMID: 41876516 Free PMC article.
TrialMatchAI: an end-to-end AI-powered clinical trial recommendation system to streamline patient-to-trial matching.
Abdallah M, Nakken S, Georges M, Bierkens M, Galvis J, Groppi A, Karkar S, Meiqari L, Rujano MA, Canham S, Dienstmann R, Fijneman R, Hovig E, Meijer G, Nikolski M. Abdallah M, et al. Nat Commun. 2026 Mar 25. doi: 10.1038/s41467-026-70509-w. Online ahead of print. Nat Commun. 2026. PMID: 41876500 Free article.
Built on fine-tuned, open-source large language models (LLMs) within a retrieval-augmented generation framework, TrialMatchAI ensures transparency and reproducibility and maintains a lightweight deployment footprint suitable for clinical environments. ...
Built on fine-tuned, open-source large language models (LLMs) within a retrieval-augmented generation framework, TrialMatchAI ensures …
Integration of alternative fragmentation techniques into standard LC-MS workflows using a single deep learning model enhances proteome coverage.
Levin N, Saylan CC, Lapin J, Demyanenko Y, Yang KL, Sidda J, Nesvizhskii AI, Wilhelm M, Mohammed S. Levin N, et al. Nat Methods. 2026 Mar 23. doi: 10.1038/s41592-026-03042-9. Online ahead of print. Nat Methods. 2026. PMID: 41872372
We demonstrate that alternative approaches, particularly electron-induced and ultraviolet photodissociation, which generate richer, more informative spectra, achieve identification efficiency competitive with CID while providing superior sequence coverage. This work establishes a …
We demonstrate that alternative approaches, particularly electron-induced and ultraviolet photodissociation, which generate richer, more inf …
ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.
Ehlers L, Wouters M, Pillay B, Delafontaine S, Bucciol G, Baggio M, Dzhus M, Hombrouck A, Damerau A, De Somer L, Schrijvers R, Vanderschueren S, Jacquemyn M, Kallinich T, Daelemans D, Ghesquière B, Agostinis P, Moens L, Meyts I. Ehlers L, et al. Cell Death Discov. 2026 Mar 23;12(1):167. doi: 10.1038/s41420-026-03027-9. Cell Death Discov. 2026. PMID: 41866403 Free PMC article.
Mini-bacterioferritins: structural insight into a ferritin-like protein from the anaerobic methane-oxidising archaeon Candidatus Methanoperedens carboxydivorans.
Wissink M, Engilberge S, Leão P, Jansen RS, Jetten MSM, Belhamri M, Lemaire ON, Royant A, Welte CU, Wagner T. Wissink M, et al. Commun Biol. 2026 Mar 21. doi: 10.1038/s42003-026-09796-4. Online ahead of print. Commun Biol. 2026. PMID: 41865068 Free article.
Phylogenetics, together with structure predictions of closely related proteins, revealed that mini-bacterioferritins form a distinct clade within the ferritin family that might conserve ancestral traits. Future research will need to investigate the physiological roles of t …
Phylogenetics, together with structure predictions of closely related proteins, revealed that mini-bacterioferritins form a distinct clade w …
LazySlide: accessible and interoperable whole-slide image analysis.
Zheng Y, Abila E, Chrenková E, Buljan I, Winkler J, Rendeiro AF. Zheng Y, et al. Nat Methods. 2026 Mar 20. doi: 10.1038/s41592-026-03044-7. Online ahead of print. Nat Methods. 2026. PMID: 41862659
Histopathological data are foundational in both biological research and clinical diagnostics but remain siloed from modern multimodal and single-cell frameworks. ...
Histopathological data are foundational in both biological research and clinical diagnostics but remain siloed from modern multimodal …
Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs.
Kabbe M, Agirre E, Carlström KE, Dumral Ö, Lor YK, Pohl FB, Ruffin N, van Bruggen D, Meijer M, Seeker LA, Bestard-Cuche N, Lederer AR, Zhang J, Ahola V, Goldman SA, Edström E, Arvidsson L, Moreira TH, Bartosovic M, Jagodic M, Williams A, Castelo-Branco G. Kabbe M, et al. Nat Neurosci. 2026 Apr;29(4):992-1006. doi: 10.1038/s41593-026-02208-0. Epub 2026 Mar 19. Nat Neurosci. 2026. PMID: 41857393 Free PMC article.
Establishing and analyzing the Simplified Human Intestinal Microbiota (SIHUMI) as a versatile in vitro gut microbiome model with qPCR-based strain-level tracking.
Ríos Colombo NS, Perez-Ibarreche M, Lanka P, Ross RP, Hill C. Ríos Colombo NS, et al. Nat Protoc. 2026 Mar 19. doi: 10.1038/s41596-026-01336-y. Online ahead of print. Nat Protoc. 2026. PMID: 41857249 Review.
A major challenge in microbiome research is the inherent complexity and inter-individual variability of the human gut microbiota. ...This qPCR-based protocol offers a validated and accessible platform for gut microbiome research, providing a standardized, strain-lev …
A major challenge in microbiome research is the inherent complexity and inter-individual variability of the human gut microbiota. ... …
Lysosomal phosphoinositide turnover acts upstream of RagGTPase-mTORC1 and controls muscle growth.
Picot M, Hifdi N, Vaucourt M, Mansat M, Li P, Singer I, Chicanne G, Stella A, Kuang S, Miceli C, Henneman NF, Payrastre B, Vandromme M, Schiltz O, Nemazanyy I, de Araujo MEG, Panasyuk G, Viaud J, Lämmerhofer M, Hnia K. Picot M, et al. Nat Metab. 2026 Mar;8(3):624-645. doi: 10.1038/s42255-026-01484-1. Epub 2026 Mar 18. Nat Metab. 2026. PMID: 41851531 Free PMC article.
Lysosomes act as metabolic signalling hubs that integrate nutrient availability to coordinate anabolic and catabolic programmes. Mechanistic target of rapamycin complex 1 (mTORC1) is activated at the lysosomal surface by amino acids through RagGTPases recruited by the lyso …
Lysosomes act as metabolic signalling hubs that integrate nutrient availability to coordinate anabolic and catabolic programmes. Mech …
Mapping the human chemical exposome for public health.
David A, Lennon S, Mercier F, Bouhlel J, Chaker J, Appenzeller BMR, Audouze K, Ayeni KI, Bailly-Chouriberry L, El Balkhi S, Barouki R, Belova L, Benmarhnia T, Bonnefille B, Bessonneau V, Bonvallot N, Bouchart V, Bouvier-Capely C, Buisson C, Bury D, Covaci A, Coumoul X, Debrauwer L, Delépée R, Denys S, Dereumeaux C, Feuerstein ML, Fillol C, Gago-Ferrero P, Garcia P, Gicquel T, Gil-Solsona R, Grova N, Habchi B, Hernandes VV, Iglesias-González A, Jamin EL, Koch HM, Lefèvre-Arbogast S, Lindh C, Louyer MV, Macheka LR, Martin JW, Marques M, Mol H, Ndaw S, Oleko A, Papazian S, Přibylová P, Price EJ, Schymanski EL, Thiele S, Warth B, Zeman F, Blanc E, Antignac JP, Le Bizec B, Samson M. David A, et al. Nat Med. 2026 Mar 18. doi: 10.1038/s41591-026-04289-7. Online ahead of print. Nat Med. 2026. PMID: 41851349 No abstract available.
Enhancing the performance of Magnets photosensors.
Baumschlager A, Weber Y, Cánovas D, Dionisi S, Khammash M. Baumschlager A, et al. Nat Commun. 2026 Mar 18. doi: 10.1038/s41467-026-70695-7. Online ahead of print. Nat Commun. 2026. PMID: 41851100 Free article.
Tailoring their properties enables their full exploitation for optogenetic regulation in basic research and applied bioengineering applications. Here, we present a simple, yet powerful strategy based on random mutagenesis coupled to high-throughput screening that allowed a …
Tailoring their properties enables their full exploitation for optogenetic regulation in basic research and applied bioengineering ap …
Underwater cultural heritage and extreme events: Storm impacts under climate change.
Germinario L, McLelland SJ, Mazzoli C. Germinario L, et al. Proc Natl Acad Sci U S A. 2026 Mar 24;123(12):e2523844123. doi: 10.1073/pnas.2523844123. Epub 2026 Mar 16. Proc Natl Acad Sci U S A. 2026. PMID: 41838914 Free PMC article.
We monitored the amount, rate, and patterns of stone erosion through innovative flume simulations and surface three-dimensional modeling, investigating its changes with time, current velocity, and properties of the materials and suspended sediments. ...
We monitored the amount, rate, and patterns of stone erosion through innovative flume simulations and surface three-dimensional model …
Synthetic aptamer mechanoreceptors enable cell-specific force sensing and temporal control via DNA circuits.
Xu T, Sethi S, Drees C, Walther A. Xu T, et al. Nat Commun. 2026 Mar 15;17(1):2492. doi: 10.1038/s41467-026-70765-w. Nat Commun. 2026. PMID: 41833970 Free PMC article.
However, engineering synthetic mechanosensing systems with both cell-specificity and programmability remains challenging, especially when targeting ubiquitous classical mechanoreceptors. ...By integrating aptamer mechanoprobes with upstream DNA reaction networks, we achiev …
However, engineering synthetic mechanosensing systems with both cell-specificity and programmability remains challenging, especially …
Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis.
Cetnarowska A, Hyldahl M, Nygård M, Dashti H, Hansen BV, Holm LK, Madsen K, Madsen MS, Shukla V, Durmaz Mitchell E, Rauch A, Madsen JGS, Claussnitzer M, Mandrup S. Cetnarowska A, et al. Nat Commun. 2026 Mar 15. doi: 10.1038/s41467-026-70401-7. Online ahead of print. Nat Commun. 2026. PMID: 41832214 Free article.
Competitive interactions shape mammalian brain network dynamics and computation.
Luppi AI, Sanz Perl Y, Vohryzek J, Ali H, Mediano PAM, Rosas FE, Milisav F, Suárez LE, Gini S, Gutierrez-Barragan D, Yee Y, Froudist-Walsh S, Gozzi A, Misic B, Deco G, Kringelbach ML. Luppi AI, et al. Nat Neurosci. 2026 Apr;29(4):915-933. doi: 10.1038/s41593-026-02205-3. Epub 2026 Mar 11. Nat Neurosci. 2026. PMID: 41814091 Free PMC article.
The model with competitive interactions provides superior subject specificity, consistently outperforming the cooperative-only model and exhibiting excellent fit to the spatiotemporal properties of the living brain. These properties were not explicitly optimized, instead e …
The model with competitive interactions provides superior subject specificity, consistently outperforming the cooperative-only model and exh …
Fat bolsters tumours against ferroptosis.
Mishima E, Conrad M. Mishima E, et al. Nat Cell Biol. 2026 Mar 11. doi: 10.1038/s41556-026-01904-0. Online ahead of print. Nat Cell Biol. 2026. PMID: 41813884 No abstract available.
High-energy resolution X-ray spectroscopy reveals bonding characteristics of La3+ homologues of actinium radiopharmaceuticals.
Ramanantoanina H, Schacherl B, Kovács A, Tagliavini M, Reynolds EM, Reitz C, Ekanayake RSK, Schäfer M, von Massow PV, Göttlicher J, Steininger R, Dardenne K, Haverkort MW, Benešová-Schäfer M, Vitova T. Ramanantoanina H, et al. Commun Chem. 2026 Mar 11;9(1):148. doi: 10.1038/s42004-026-01929-4. Commun Chem. 2026. PMID: 41813852 Free article.
This allows us to establish a direct correlation between spectroscopic observables and theoretical metrics for bonding properties, offering a framework to understand the coordination chemistry of f-elements. Beyond advancing fundamental chemistry, our findings will also in …
This allows us to establish a direct correlation between spectroscopic observables and theoretical metrics for bonding properties, offering …
Water-generated dangling linkers in a metal-organic framework.
Fu Y, Yao Y, Paul S, Mochizuki K, De Paëpe G. Fu Y, et al. Nat Commun. 2026 Mar 11. doi: 10.1038/s41467-026-70247-z. Online ahead of print. Nat Commun. 2026. PMID: 41813680 Free article.
Metal-Organic Frameworks (MOFs) have attracted widespread attention for their applications in water-related contexts. ...By challenging conventional wisdom, our research has introduced a reversible molecular structure evolution scenario, redefining the understanding …
Metal-Organic Frameworks (MOFs) have attracted widespread attention for their applications in water-related contexts. ...By challengi …
A high-resolution spatiotemporal wildfire propagation dataset for the Mediterranean and Europe.
Müller S, Hofmann-Böllinghaus A, Chen Z, Vogel K, Benner P. Müller S, et al. Sci Data. 2026 Mar 11;13(1):389. doi: 10.1038/s41597-026-06965-2. Sci Data. 2026. PMID: 41813679 Free PMC article.
With its high level of spatiotemporal precision, FireSpread_MedEU provides essential data for the development and validation of machine learning models or wildfire simulation models. It opens new research opportunities in wildfire behavior analysis, risk assessment, and pr …
With its high level of spatiotemporal precision, FireSpread_MedEU provides essential data for the development and validation of machine lear …
Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.
Bhattacharjee D, Sharma A, Dai K, Pramod T, Saile L, Thomann R, Pappas CG. Bhattacharjee D, et al. Nat Commun. 2026 Mar 11;17(1):2407. doi: 10.1038/s41467-026-70199-4. Nat Commun. 2026. PMID: 41813677 Free PMC article.
Here, we report an abiotic aqueous reaction network in which aminoacyl phosphate esters bearing alkyne groups undergo a programmed sequence of covalent transformations governed by peptide-based nucleophiles. Phenolic nucleophiles promote rapid copper-catalyzed azide-alkyne …
Here, we report an abiotic aqueous reaction network in which aminoacyl phosphate esters bearing alkyne groups undergo a programmed se …
Proteomic landscape of Ewing sarcoma primary tumors and metastases.
Gordon S, Mohan V, Shukrun R, Golani O, Metzger S, Sher O, Manisterski M, Oren R, Fellus-Alyagor L, Beck L, Addadi Y, Dekel B, Elhasid R, Geiger T. Gordon S, et al. Nat Commun. 2026 Mar 11. doi: 10.1038/s41467-026-70449-5. Online ahead of print. Nat Commun. 2026. PMID: 41813675 Free article.
Allelic variation at a single locus distinguishes spring and winter faba beans.
Zhang H, Windhorst A, Bornhofen E, Tulpova Z, Novak P, Macas J, Simkova H, Nadzieja M, Kim JM, Cram D, Cao Y, Konkin DJF, Sass O, Welna G, Himmelbach A, Mascher M, Link W, Kwon SJ, Yang TJ, Andersen SU, Jayakodi M. Zhang H, et al. Nat Genet. 2026 Mar;58(3):655-663. doi: 10.1038/s41588-026-02524-y. Epub 2026 Mar 10. Nat Genet. 2026. PMID: 41807799 Free PMC article.
A neural signature of adaptive mentalization.
Buergi N, Aydogan G, Konovalov A, Ruff CC. Buergi N, et al. Nat Neurosci. 2026 Apr;29(4):934-944. doi: 10.1038/s41593-026-02219-x. Epub 2026 Mar 9. Nat Neurosci. 2026. PMID: 41803318 Free PMC article.
Mentalization, inferring others' emotions and intentions, is crucial for human social interactions and is impaired in various brain disorders. While previous neuroscience research has focused on static mentalization strategies, we know little about how the brain adaptively …
Mentalization, inferring others' emotions and intentions, is crucial for human social interactions and is impaired in various brain disorder …
Optimizing photon conversion routes in cinnamate derivatives.
Hymas M, Dalton J, Romanov I, Sanders H, Barbatti M, Toldo JM, Buma WJ, Stavros VG. Hymas M, et al. Commun Chem. 2026 Mar 9. doi: 10.1038/s42004-026-01963-2. Online ahead of print. Commun Chem. 2026. PMID: 41803301 Free article.
Purkinje cell intrinsic activity shapes cerebellar development and function.
Osório C, White JJ, Torrents-Solé P, Yang J, Mandemaker N, Olivero F, Kirwan F, Post L, Hemmat Z, de Winter F, Regolo E, Fiocchi FR, Serra I, Tjon S, Ozgur Z, van den Hout MCGN, van IJcken WFJ, López-Bendito G, Badura A, Lim L, van Woerden GM, Schonewille M. Osório C, et al. Nat Commun. 2026 Mar 9. doi: 10.1038/s41467-026-70355-w. Online ahead of print. Nat Commun. 2026. PMID: 41803111 Free article.
Spatio-spectral light-by-light moulding in multimode fibre.
Arosa Y, Mansuryan T, Poisson A, Gemechu WA, Krupa K, Ferraro M, Mangini F, Wetzel B, Wabnitz S, Tonello A, Couderc V. Arosa Y, et al. Nat Commun. 2026 Mar 7. doi: 10.1038/s41467-026-70057-3. Online ahead of print. Nat Commun. 2026. PMID: 41794785 Free article.
Addressing Vitamin B12 deficiency through aeroponic fortification of a salad crop (Pisum sativum).
Eldridge BM, Javvadi SG, Perez-Moral N, Sweetman J, de Barros Dantas LL, Saha S, Lynch DA, Hunt T, Clough SE, Toussaint J, Worrall A, Manzoni LR, Robinson N, Franklin KA, Edwards CH, Clarke J, Farmer J, Warren M, Dodd AN. Eldridge BM, et al. Commun Biol. 2026 Mar 6. doi: 10.1038/s42003-026-09764-y. Online ahead of print. Commun Biol. 2026. PMID: 41792466 Free article.
RAG1/2 expression in IGH-switched follicular lymphoma associated with transformation to high-grade B-cell lymphoma.
Lonardi S, Cancila V, Morello G, Varano G, Balzarini P, Pellegrini V, Albertini E, Giampaolo S, Pietrini I, Thanasi H, Sindaco P, Piazza F, Manni S, Lorenzini D, Pruneri G, Dei Tos AP, Ponzoni M, Facchetti F, Pizzi M, Lorenzi L, Tripodo C, Casola S. Lonardi S, et al. Leukemia. 2026 Mar 6. doi: 10.1038/s41375-026-02896-4. Online ahead of print. Leukemia. 2026. PMID: 41792441 No abstract available.
An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.
Warren A, Holleran L, Agartz I, Andreassen OA, Banaj N, Cannon DM, Corvin A, Green M, Gur R, Hashimoto R, Hong E, Hoschl C, Kochunov P, Lawrie SM, McDonald C, Morris D, Mothersill D, Neilson E, Pantelis C, Piras F, Rasser PE, Roalf D, Satterthwaite TD, Schall U, Sim K, Skoch A, Spalletta G, Spaniel F, Thomopoulos S, Tomecek D, Zalesky A, Thompson PM, Jahanshad N, Turner JA, van Erp TGM, Donohoe G; ENIGMA Consortium Schizophrenia Working Group. Warren A, et al. Schizophrenia (Heidelb). 2026 Mar 6. doi: 10.1038/s41537-026-00728-z. Online ahead of print. Schizophrenia (Heidelb). 2026. PMID: 41792186 Free article.
Segmented filamentous bacteria are worldwide human gut commensals.
Kiran S, Cruz AR, Daniau A, Ma B, Marbouty M, Pipoli Da Fonseca J, Legrand A, Baudry L, Cokelaer T, Bensussan M, Moya-Nilges M, Garneau J, Monot M, Ochieng JB, Antonio M, Tamboura B, de Vos WM, Salonen A, Hossain J, Omore R, Sow SO, Sansonetti PJ, Ravel J, Cerf-Bensussan N, Schnupf P. Kiran S, et al. Nat Commun. 2026 Mar 5. doi: 10.1038/s41467-026-70010-4. Online ahead of print. Nat Commun. 2026. PMID: 41786702 Free article.
Individual Brain Charting: fifth release of high-resolution fMRI data for cognitive mapping.
Ponce AF, Aggarwal H, Shankar S, Torre JJ, Pinho AL, Thual A, Ginisty C, Lecomte Y, Berland V, Beriot L, Laurier L, Joly-Testault V, Médiouni-Cloarec G, Hertz-Pannier L, Doublé C, Martins B, Amalric M, Dehaene S, Diersch N, Wolbers T, Shafto MA, O'Doherty JP, Man V, Dolan RJ, Poldrack RA, Stigliani A, Grill-Spector K, Douglas D, Lee ACH, Keator DB, Potkin SG, Chang DHF, Troje NF, Kuo BC, Astle DE, Thirion B. Ponce AF, et al. Sci Data. 2026 Mar 5. doi: 10.1038/s41597-026-06869-1. Online ahead of print. Sci Data. 2026. PMID: 41781395 Free article.
As the dataset becomes larger, the collection of the corresponding topographies becomes more comprehensive, leading to enhanced brain-atlasing frameworks. Aligned with open-access and data-sharing standards, this dataset emphasizes transparency and collaborative researc
As the dataset becomes larger, the collection of the corresponding topographies becomes more comprehensive, leading to enhanced brain-atlasi …
Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial.
Català-Moll F, Blázquez-Bondia C, Farré-Badia J, Torres F, Manzardo C, Bonfill E, Curran A, Domingo P, Podzamczer D, Force L, Falcó V, Parera M, Casadellà M, Miró JM, Noguera-Julian M, Paredes R; ADVANZ-4 MISTRAL investigators. Català-Moll F, et al. Nat Commun. 2026 Mar 4;17(1):2022. doi: 10.1038/s41467-026-69846-7. Nat Commun. 2026. PMID: 41781390 Free PMC article. Clinical Trial.
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.
Fisher K, Garcia MA, Frattari GS, Naasz C, Zhuo J, Rosás-Umbert M, Dietz LL, Juhl AK, Falling Iversen E, Olesen R, Schleimann MH, Pahus MH, Johansen IS, Henderson M, Carrere L, Roseto I, Gao C, Yu XG, Fray EJ, Aydin B, Lubbeck D, Lai J, Simonetti FR, Danesh A, Miller I, Mendoza P, Niessl J, Gaebler C, Seaman MS, Kaufmann DE, Lehmann C, Gruell H, Klein F, Caskey M, Nussenzweig MC, Tolstrup M, Jones RB, Gunst JD, Siliciano JD, Lichterfeld M, Siliciano RF, Søgaard OS. Fisher K, et al. Nat Immunol. 2026 Apr;27(4):812-826. doi: 10.1038/s41590-026-02448-z. Epub 2026 Mar 3. Nat Immunol. 2026. PMID: 41776101 Free PMC article.
Potent autologous neutralizing antibodies and polyfunctional HIV-1-specific CD4(+) and CD8(+) T cell responses, pre-programmed for antigen response, were present before, and persisted during, ART interruption. ...
Potent autologous neutralizing antibodies and polyfunctional HIV-1-specific CD4(+) and CD8(+) T cell responses, pre-programmed for an …
Unfair Inequality in Education: A Benchmark for AI-Fairness Research.
Giovanelli J, Magnini M, Ciatto G, Marrero AS, Borghesi A, Marrero GA, Calegari R. Giovanelli J, et al. Sci Data. 2026 Mar 2;13(1):572. doi: 10.1038/s41597-026-06827-x. Sci Data. 2026. PMID: 41771897 Free article.
This paper introduces a novel benchmark dataset designed to support fairness-oriented research in artificial intelligence within the educational domain. The dataset originates from longitudinal survey data collected by the Agencia Canaria de Calidad Universitaria y Evaluac …
This paper introduces a novel benchmark dataset designed to support fairness-oriented research in artificial intelligence within the …
Wheat historical phenotypic data from European genebanks as an important resource for research and breeding.
Le Floch E, Adam-Blondon AF, Alaux M, Bardet E, Bas N, Bassi FM, Boczkowska M, Bolc P, Brouwer M, Chalhoub B, De Blok R, Desheva G, Etukala JR, Flores R, Galit I, Groenink W, Hauptvogel R, Hoekstra R, Kehel Z, Kersey P, Kowalik R, Kumar S, Kyosev B, Lange M, Lazăr C, Marinciu C, Martín-Lammerding D, Motor A, Pachipala M, Pallero-Baena M, Petcu E, Pietrusińska-Radzio A, Podyma W, Pommier C, Puchta-Jasińska M, Puła S, Reiniers L, Ruff J, Ruiz M, Sansoni F, Schierscher B, Șerban G, Serex S, Vaccino P, Van Treuren R, Vasile M, Vasilescu L, Visioni A, Weise S, Wijnker E, Zaim M, Reif JC, Berkner MO. Le Floch E, et al. Sci Data. 2026 Mar 2;13(1):566. doi: 10.1038/s41597-026-06908-x. Sci Data. 2026. PMID: 41771879 Free article.
Q-optimised nanoelectromechanical diamond resonators.
Thomas ELH, Mandal S, Leigh WGS, Williams OA. Thomas ELH, et al. Microsyst Nanoeng. 2026 Mar 3;12(1):74. doi: 10.1038/s41378-026-01189-1. Microsyst Nanoeng. 2026. PMID: 41771850 Free PMC article.
Persistent negative symptoms in the EULAST cohort: impact on functional outcome.
Giuliani L, Pezzella P, Giordano GM, Perrottelli A, Mucci A, Bucci P, Bitter I, Arango C, Luykx JJ, Díaz-Caneja CM, Ebdrup BH, Davidson M, Tiihonen J, Winter-van Rossum I, Galderisi S. Giuliani L, et al. Schizophrenia (Heidelb). 2026 Mar 2;12(1):36. doi: 10.1038/s41537-026-00739-w. Schizophrenia (Heidelb). 2026. PMID: 41766016 Free article.
Our findings confirm that long-term persistence of negative symptoms, both primary and secondary, contributes to poor functional outcome. Future research should focus on identifying predictors of symptom persistence to guide the development of targeted interventions aimed …
Our findings confirm that long-term persistence of negative symptoms, both primary and secondary, contributes to poor functional outcome. Fu …
Dynamic subcellular proteomics identifies regulators of adipocyte insulin action.
Conway OJ, Christopher JA, Breckels LM, Li H, Menon D, Birla M, Hawkins BL, Liang L, Patel S, Koumanov F, Gershlick DC, Savage DB, Weekes MP, Lilley KS, Fazakerley DJ. Conway OJ, et al. Nat Commun. 2026 Feb 28;17(1):3310. doi: 10.1038/s41467-026-70116-9. Nat Commun. 2026. PMID: 41764265 Free article.
Oscillatory brain state-dependent stimulation with transcranial magnetic stimulation combined with electroencephalography.
Zrenner C, Belardinelli P, Ziemann U. Zrenner C, et al. Nat Protoc. 2026 Feb 27. doi: 10.1038/s41596-025-01309-7. Online ahead of print. Nat Protoc. 2026. PMID: 41760982 Review.
In the procedure, we cover brain MRI and image segmentation for anatomical modeling and accurate source reconstruction of the EEG signals, EEG recording without TMS to validate the origin of the oscillation of interest and to determine its phase targeting accuracy, and the main e …
In the procedure, we cover brain MRI and image segmentation for anatomical modeling and accurate source reconstruction of the EEG signals, E …
A modern perspective on antiferroelectrics.
Catalan G, Gruverman A, Íñiguez-González J, Meier D, Trassin M. Catalan G, et al. Nat Mater. 2026 Apr;25(4):557-565. doi: 10.1038/s41563-026-02483-z. Epub 2026 Feb 27. Nat Mater. 2026. PMID: 41760949 Review.
NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors.
Humer D, Klepsch V, Rieder D, Hölzl I, Schreiber D, Lang V, Koutník J, Peer S, Sajinovic T, Wille V, Fürst A, Savic D, Diem G, Posch W, Skvortsova II, Krogsdam A, Sopper S, Kobold S, Trajanoski Z, Siegmund K, Thuille N, Gruber T, Wolf D, Baier G. Humer D, et al. Nat Commun. 2026 Feb 27;17(1):3264. doi: 10.1038/s41467-026-69796-0. Nat Commun. 2026. PMID: 41760655 Free article.
Next-generation multicolor indicators for in vivo imaging of norepinephrine.
Rohner VL, Curreli S, Lamothe-Molina PJ, Kagiampaki Z, Yee AG, Nardin C, Eschholz L, Dieter A, Foustoukos G, Milanese P, Banterle L, Childs T, Canziani A, Dernic J, Ravotto L, Bhat MA, Sönmez L, Wasielewski LM, Ziebarth T, Molnar MI, Huang G, Masseck OA, Weber B, Reiner A, Lüthi A, Ford CP, Wiegert JS, Ruediger S, Fellin T, Patriarchi T. Rohner VL, et al. Nat Methods. 2026 Mar;23(3):636-652. doi: 10.1038/s41592-026-03006-z. Epub 2026 Feb 26. Nat Methods. 2026. PMID: 41748975 Free PMC article.
Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1.
Heinen S, Tiku V, Grevel A, Hugenroth M, Ellenrieder L, Steymans I, Licheva M, Bonini S, Oeljeklaus S, Okon N, Lambertz J, Poppe S, Song J, Fester L, Meisinger C, Warscheid B, Eckhardt M, Wiedemann N, Winter D, Kraft C, den Brave F, Bohnert M, Pfanner N, Becker T. Heinen S, et al. Nat Cell Biol. 2026 Mar;28(3):436-448. doi: 10.1038/s41556-026-01890-3. Epub 2026 Feb 26. Nat Cell Biol. 2026. PMID: 41748941
Rumor propagation on hypergraphs.
Oliveira KA, Traversa P, Ferraz de Arruda G, Moreno Y. Oliveira KA, et al. Nat Commun. 2026 Feb 26;17(1):3253. doi: 10.1038/s41467-026-70096-w. Nat Commun. 2026. PMID: 41748641 Free PMC article.
Negative emissions to mitigate Earth system risks.
Gasser T, Rezai A, Cheritel C, Baklanov A, Obersteiner M. Gasser T, et al. Nat Commun. 2026 Feb 26;17(1):3212. doi: 10.1038/s41467-026-69896-x. Nat Commun. 2026. PMID: 41748581 Free PMC article.
Here, we derive global climate strategies with an ex-ante approach, employing an integrated assessment framework that embeds estimates of physical uncertainty obtained through Bayesian fusion of Earth system models' and observations' data. ...
Here, we derive global climate strategies with an ex-ante approach, employing an integrated assessment framework that embeds estimate …
Photorespiration is linked to DNA methylation by formate as a one-carbon source.
Hankofer V, Ghirardo A, Obermaier L, Poschet G, Kumar JS, Gross I, Durner J, Rychlik M, Wirtz M, Hell R, Schnitzler JP, Groth M. Hankofer V, et al. Nat Plants. 2026 Mar;12(3):653-664. doi: 10.1038/s41477-026-02222-x. Epub 2026 Feb 25. Nat Plants. 2026. PMID: 41741813 Free PMC article.
These findings establish a metabolic link between photorespiration and epigenome stability and provide a framework for understanding methylome dynamics under rising CO(2) levels and other environmental influences on photorespiration....
These findings establish a metabolic link between photorespiration and epigenome stability and provide a framework for understanding …
Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders.
King S, Zhang Z, Robinson L, Whelan R, Nees F, Bobou M, Banaschewski T, Barker GJ, Bokde ALW, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka MN, Vaidya N, Walter H, Winterer J, Broulidakis MJ, van Noort BM, Stringaris A, Zhang Y, Sinclair J, Schumann G, Schmidt U, Desrivières S, Cotter D, Young AH, Donohoe G, Wolsztynski E. King S, et al. Commun Biol. 2026 Feb 25. doi: 10.1038/s42003-025-09400-1. Online ahead of print. Commun Biol. 2026. PMID: 41741790 Free article.
ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks.
Aird EJ, Serrano-Benitez A, Siegner SM, Cannavo E, Belotserkovskaya R, Gueorguieva N, Fielden J, Cullot G, Ammann S, Bader AS, Gupta V, Andrieux G, Raab R, Del Rey González M, Cathomen T, Cejka P, Corn JE, Jackson SP. Aird EJ, et al. Nat Commun. 2026 Feb 25;17(1):2743. doi: 10.1038/s41467-026-69843-w. Nat Commun. 2026. PMID: 41741470 Free PMC article.
Reconstruction of the lifeways of Central European Late Bronze Age communities using ancient DNA, isotope and osteoarchaeological analyses.
Orfanou E, Ghalichi A, Rohrlach AB, Paust E, Andrades Valtueña A, Ernée M, Furmanek M, Hałuszko A, Hermes T, Himmel M, Ilgner J, Krause J, Küßner M, Lamnidis TC, Lucas M, Adámková Malyková D, Meller H, Neumann GU, Papac L, Penske S, Salinger M, Schrader SA, Schunke T, Semerau L, Smejtek L, Traverso L, Zach B, Spengler R, Stockhammer PW, Wahl J, Snoeck C, Ettel P, Schneider FN, Roberts P, Haak W. Orfanou E, et al. Nat Commun. 2026 Feb 24;17(1):1992. doi: 10.1038/s41467-026-69895-y. Nat Commun. 2026. PMID: 41735297 Free PMC article.
One-dimensional photonic crystal nano-ridge surface emitting lasers epitaxially grown on a standard 300 mm silicon wafer.
Fahmy EMB, Ouyang Z, Colucci D, Le Thomas N, Van Campenhout J, Kunert B, Van Thourhout D. Fahmy EMB, et al. Light Sci Appl. 2026 Feb 24;15(1):120. doi: 10.1038/s41377-025-02061-z. Light Sci Appl. 2026. PMID: 41735264 Free PMC article.
This breakthrough holds significant potential for integrated silicon photonics, enabling a wide range of applications and opening new research avenues. In this approach, the active material is grown not as a uniform layer but rather as parallel nano-ridge (NR) arrays. ...
This breakthrough holds significant potential for integrated silicon photonics, enabling a wide range of applications and opening new res
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.
Frischholz S, Schuster EM, Grotz M, Schülein C, Benz J, Kocher K, Klotz L, Varga S, Hiltner T, Alsalameh R, Esse J, Träger J, Held J, Graw F, Pahle J, Spriewald B, Gattinoni L, Buchholz VR, Drost F, Schubert B, Rothenfußer S, Busch DH, Bogdan C, Schober K. Frischholz S, et al. Nat Immunol. 2026 Mar;27(3):452-462. doi: 10.1038/s41590-026-02421-w. Epub 2026 Feb 24. Nat Immunol. 2026. PMID: 41735532 Free PMC article.
Crystal-facet-directed all-vacuum-deposited perovskite solar cells.
Shen X, Hui WT, Hu S, Yang F, Wang J, Yao J, Louwen A, Tam BST, Rong L, McMeekin DP, Lohmann K, Yuan Q, Naylor MC, Kober-Czerny M, Seo S, Holzhey P, Zaininger KA, Christoforo MG, Carroy P, Barth V, Yeung FSY, Noel NK, Johnston M, Lin YH, Snaith HJ. Shen X, et al. Nat Mater. 2026 Feb 23. doi: 10.1038/s41563-026-02494-w. Online ahead of print. Nat Mater. 2026. PMID: 41731208
Double-phase metasurface operators for all-optical image processing.
Yu L, Singh HJ, Pietila J, Caglayan H. Yu L, et al. Light Sci Appl. 2026 Feb 23;15(1):119. doi: 10.1038/s41377-025-02153-w. Light Sci Appl. 2026. PMID: 41730839 Free PMC article.
We experimentally showcase key computational operations, including first-order differentiation, cross-correlation, vertex detection, and Laplacian differentiation. Additionally, we extend this framework to high-resolution complex holography, achieving subwavelength-scale v …
We experimentally showcase key computational operations, including first-order differentiation, cross-correlation, vertex detection, and Lap …
Mast-cell derived nerve growth factor drives ILC2 pro-tumoral functions in bladder cancer.
Falquet M, El Ahanidi H, Gomez-Cadena A, Su Z, Cornu A, Wyss T, Kizil B, Pick R, Falamaki K, Wirapati P, Fiordi B, Senoner I, Maresca DC, Kallal N, Guedj D, Kreutzfeldt M, Tille JC, Leblond MM, Michaud K, Pesce S, Candiani S, Golebski K, Dagher J, Charrier M, Pressacco Brossier C, Grobet-Jeandin E, Marone R, Hugues S, Jeker LT, Verdeil G, Merkler D, Marcenaro E, Scheiermann C, Attaleb M, Benamran D, Tsantoulis P, Ercolano G, Trabanelli S, Jandus C. Falquet M, et al. Nat Commun. 2026 Feb 21;17(1):3061. doi: 10.1038/s41467-026-69841-y. Nat Commun. 2026. PMID: 41723132 Free PMC article.
The ADePT framework for assessing autonomous laboratory robotics.
Salazar-Villacis P, Benyahia B. Salazar-Villacis P, et al. Commun Chem. 2026 Feb 20;9(1):99. doi: 10.1038/s42004-026-01932-9. Commun Chem. 2026. PMID: 41720921 Free PMC article. Review.
This perspective outlines key milestones and introduces the ADePT framework, which defines four core dimensions of robotic capability proficiency: adaptability and learning, dexterity, perception, and task complexity. ...
This perspective outlines key milestones and introduces the ADePT framework, which defines four core dimensions of robotic capability …
Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling.
Scheck R, Melzer M, Gladkov G, Leyre L, Ward AR, Reeves DB, Perkins N, Huynh TT, McMahon DK, Bosch RJ, Macatangay BJ, Cyktor JC, Eron JJ, Mellors JW, Gandhi RT, Buchauer L, Jones RB, Gaebler C. Scheck R, et al. Nat Commun. 2026 Feb 20;17(1):2975. doi: 10.1038/s41467-026-69413-0. Nat Commun. 2026. PMID: 41720775 Free PMC article.
What does BCL-2 do? From new molecular insights to the clinical implications.
Croce CM, Tait SWG, Garcia-Sáez AJ, Villunger A, Letai A, Walter HS, Dyer MJS, Green DR, Shi Y, Melino G. Croce CM, et al. Cell Death Differ. 2026 Feb 19. doi: 10.1038/s41418-025-01607-3. Online ahead of print. Cell Death Differ. 2026. PMID: 41714805 Review.
Celebrating the collaborative, interdisciplinary efforts that transformed fundamental discoveries into life-saving therapies, this account underscores both the triumphs and the "potholes" encountered on the path to understanding apoptosis, while identifying open questions for ong …
Celebrating the collaborative, interdisciplinary efforts that transformed fundamental discoveries into life-saving therapies, this account u …
Harnessing microalgae for the biosynthesis of molecular crystals.
Wagner A, Margalit N, Fishman Y, Indri SS, Upcher A, Baranov M, Nativ-Roth E, Hughes CE, Kariuki BM, Haataja JS, Schertel L, Yates JR, Harris KDM, Place AR, Mojzes P, Palmer BA. Wagner A, et al. Nat Biotechnol. 2026 Feb 19. doi: 10.1038/s41587-026-03006-6. Online ahead of print. Nat Biotechnol. 2026. PMID: 41714416
Harnessing intermediate-scale bioreactors for next-generation macrophage production and application.
Saleh F, Valdivia Malqui EE, Gensch I, Schinke M, Kappelhøj M, Nikolouli E, Nguyen AHH, Jang MS, Basílio-Queirós D, Lachmann N. Saleh F, et al. Nat Protoc. 2026 Feb 18. doi: 10.1038/s41596-025-01313-x. Online ahead of print. Nat Protoc. 2026. PMID: 41709011 Review.
However, cost-effective, standardized intermediate-scale bioreactor systems tailored for early-stage research and drug discovery in academia remain limited. Here, we present an extension of our previously published protocol that is feeder free, semi-defined and user friend …
However, cost-effective, standardized intermediate-scale bioreactor systems tailored for early-stage research and drug discovery in a …
Isolable radical cation and dication of dialumene.
Liu X, Kostenko A, Körber E, Zhu H, Meyer K, Inoue S. Liu X, et al. Nat Commun. 2026 Feb 18;17(1):1937. doi: 10.1038/s41467-026-69607-6. Nat Commun. 2026. PMID: 41708614 Free PMC article.
Structural defects in amyloid-β fibrils drive secondary nucleation.
Hu J, Scheidt T, Thacker D, Axell E, Stemme E, Łapińska U, Wennmalm S, Meisl G, Curk S, Andreasen M, Vendruscolo M, Arosio P, Šarić A, Schmit JD, Knowles TPJ, Sparr E, Linse S, Michaels TCT, Dear AJ. Hu J, et al. Nat Commun. 2026 Feb 18;17(1):1933. doi: 10.1038/s41467-026-69377-1. Nat Commun. 2026. PMID: 41708600 Free PMC article.
Learning alters salience and proactive attentional priority.
Duncan DH, van Moorselaar D, Theeuwes J. Duncan DH, et al. Commun Psychol. 2026 Feb 17;4(1):57. doi: 10.1038/s44271-026-00411-0. Commun Psychol. 2026. PMID: 41703279 Free PMC article.
The ability to ignore salient yet irrelevant stimuli is essential to accomplishing even simple tasks. Previous research has shown that observers are better able to suppress distracting stimuli via experience; yet the precise mechanisms of this learned suppression is a subj …
The ability to ignore salient yet irrelevant stimuli is essential to accomplishing even simple tasks. Previous research has shown tha …
Enhanced third-order optical nonlinearity in a dipolar carbene-metal-amide material with two-photon excited delayed fluorescence.
Nwosu ID, Matasović L, Ramos TN, Phuoc NL, Londi G, Gillett AJ, Toolan DTW, Smith CT, Whitehead GFS, Blanchard-Desce M, Daniel J, Linnolahti M, Olivier Y, Romanov AS. Nwosu ID, et al. Commun Chem. 2026 Feb 17;9(1):135. doi: 10.1038/s42004-026-01928-5. Commun Chem. 2026. PMID: 41703230 Free PMC article.
Bright red CMA 2P-TADF material shows excellent photostability (LT(50) = 3 h) to 20 mW femtosecond pulsed laser excitation at 1000 nm, encouraging further CMA exploration for future applications in advanced photonic technologies requiring third-order nonlinear optical prop …
Bright red CMA 2P-TADF material shows excellent photostability (LT(50) = 3 h) to 20 mW femtosecond pulsed laser excitation at 1000 nm …
Learning the committor without collective variables.
Contreras Arredondo S, Tang C, Talmazan RA, Megías A, Chen CG, Chipot C. Contreras Arredondo S, et al. Nat Comput Sci. 2026 Feb 17. doi: 10.1038/s43588-026-00958-2. Online ahead of print. Nat Comput Sci. 2026. PMID: 41703093
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