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Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay.
Hough SH, Jhujh SS, Awwad SW, Lewis OE, Lam S, Thomas JC, Mosler T, Bader A, Bartik L, McKee S, Amudhavalli S, Colin E, Damseh N, Clement E, Cacheiro P, Majumdar A, Smedley D, Fluss J, Giannini R, Thiffault I, Zagnoli Vieira G, Belotserkovskaya R, Smerdon SJ, Beli P, Galanty Y, Carnie CJ, Stewart GS, Jackson SP. Hough SH, et al. EMBO Mol Med. 2026 Feb;18(2):492-513. doi: 10.1038/s44321-025-00352-x. Epub 2025 Dec 19. EMBO Mol Med. 2026. PMID: 41420108 Free PMC article.
INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors.
Dietrich C, Trub A, Ahn A, Taylor M, Ambani K, Chan KT, Lu KH, Mahendra CA, Blyth C, Coulson R, Ramm S, Watt AC, Matsa SK, Bisi J, Strum J, Roberts P, Goel S. Dietrich C, et al. Cancer Discov. 2024 Mar 1;14(3):446-467. doi: 10.1158/2159-8290.CD-23-0954. Cancer Discov. 2024. PMID: 38047585 Free PMC article.
Using cell-based assays, patient-derived xenografts (PDX), and transgenic mouse models, we show that INX-315 (i) promotes retinoblastoma protein hypophosphorylation and therapy-induced senescence (TIS) in CCNE1-amplified tumors, leading to durable control of tumor growth; (ii …
Using cell-based assays, patient-derived xenografts (PDX), and transgenic mouse models, we show that INX-315 (i) promotes retinoblastoma pro …