Amaral MD - Search Results

1

How to determine the mechanism of action of CFTR modulator compounds: A gateway to theranostics.

Amaral MD. Amaral MD. Eur J Med Chem. 2021 Jan 15;210:112989. doi: 10.1016/j.ejmech.2020.112989. Epub 2020 Nov 5. Eur J Med Chem. 2021. PMID: 33190956 Review.

2

CFTR and chaperones: processing and degradation.

Amaral MD. Amaral MD. J Mol Neurosci. 2004;23(1-2):41-8. doi: 10.1385/JMN:23:1-2:041. J Mol Neurosci. 2004. PMID: 15126691 Review.

3

Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts.

Ramalho AS, Beck S, Farinha CM, Clarke LA, Heda GD, Steiner B, Sanz J, Gallati S, Amaral MD, Harris A, Tzetis M. Ramalho AS, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:11-5. doi: 10.1016/j.jcf.2004.05.004. J Cyst Fibros. 2004. PMID: 15463918 Free article. Review.

4

Quantitative methods for the analysis of CFTR transcripts/splicing variants.

Amaral MD, Clarke LA, Ramalho AS, Beck S, Broackes-Carter F, Rowntree R, Mouchel N, Williams SH, Harris A, Tzetis M, Steiner B, Sanz J, Gallati S, Nissim-Rafinifa M, Kerem B, Hefferon T, Cutting GR, Goina E, Pagani F. Amaral MD, et al. J Cyst Fibros. 2004 Aug;3 Suppl 2:17-23. doi: 10.1016/j.jcf.2004.05.047. J Cyst Fibros. 2004. PMID: 15463919 Free article. Review.

5

Antibodies for CFTR studies.

Mendes F, Farinha CM, Roxo-Rosa M, Fanen P, Edelman A, Dormer R, McPherson M, Davidson H, Puchelle E, De Jonge H, Heda GD, Gentzsch M, Lukacs G, Penque D, Amaral MD. Mendes F, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:69-72. doi: 10.1016/j.jcf.2004.05.016. J Cyst Fibros. 2004. PMID: 15463931 Free article. Review.

6

Processing of CFTR: traversing the cellular maze--how much CFTR needs to go through to avoid cystic fibrosis?

Amaral MD. Amaral MD. Pediatr Pulmonol. 2005 Jun;39(6):479-91. doi: 10.1002/ppul.20168. Pediatr Pulmonol. 2005. PMID: 15765539 Review.

7

Therapy through chaperones: sense or antisense? Cystic fibrosis as a model disease.

Amaral MD. Amaral MD. J Inherit Metab Dis. 2006 Apr-Jun;29(2-3):477-87. doi: 10.1007/s10545-006-0251-x. J Inherit Metab Dis. 2006. PMID: 16763920 Review.

8

Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis.

Amaral MD, Kunzelmann K. Amaral MD, et al. Trends Pharmacol Sci. 2007 Jul;28(7):334-41. doi: 10.1016/j.tips.2007.05.004. Epub 2007 Jun 18. Trends Pharmacol Sci. 2007. PMID: 17573123 Review.

9

Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.

Pissarra LS, Farinha CM, Xu Z, Schmidt A, Thibodeau PH, Cai Z, Thomas PJ, Sheppard DN, Amaral MD. Pissarra LS, et al. Among authors: amaral md. Chem Biol. 2008 Jan;15(1):62-9. doi: 10.1016/j.chembiol.2007.11.012. Chem Biol. 2008. PMID: 18215773

10

Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients.

Ramalho AS, Lewandowska MA, Farinha CM, Mendes F, Gonçalves J, Barreto C, Harris A, Amaral MD. Ramalho AS, et al. Among authors: amaral md. Cell Physiol Biochem. 2009;24(5-6):335-46. doi: 10.1159/000257426. Epub 2009 Nov 4. Cell Physiol Biochem. 2009. PMID: 19910674 Free PMC article.

11

Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins.

Da Paula AC, Sousa M, Xu Z, Dawson ES, Boyd AC, Sheppard DN, Amaral MD. Da Paula AC, et al. Among authors: amaral md. J Biol Chem. 2010 Aug 27;285(35):27033-27044. doi: 10.1074/jbc.M110.120352. Epub 2010 Jun 15. J Biol Chem. 2010. PMID: 20551307 Free PMC article.

12

Targeting CFTR: how to treat cystic fibrosis by CFTR-repairing therapies.

Amaral MD. Amaral MD. Curr Drug Targets. 2011 May;12(5):683-93. doi: 10.2174/138945011795378586. Curr Drug Targets. 2011. PMID: 21039334 Review.

13

Functional genomics assays to study CFTR traffic and ENaC function.

Almaça J, Dahimène S, Appel N, Conrad C, Kunzelmann K, Pepperkok R, Amaral MD. Almaça J, et al. Among authors: amaral md. Methods Mol Biol. 2011;742:249-64. doi: 10.1007/978-1-61779-120-8_15. Methods Mol Biol. 2011. PMID: 21547737

14

Introduction to section III: resources for CFTR research.

Amaral MD. Amaral MD. Methods Mol Biol. 2011;742:281-3. doi: 10.1007/978-1-61779-120-8_17. Methods Mol Biol. 2011. PMID: 21547739

15

Quantification of CFTR transcripts.

Ramalho AS, Clarke LA, Amaral MD. Ramalho AS, et al. Among authors: amaral md. Methods Mol Biol. 2011;741:115-35. doi: 10.1007/978-1-61779-117-8_9. Methods Mol Biol. 2011. PMID: 21594782

16

Introduction to section III: biochemical methods to study CFTR protein.

Amaral MD, Lukacs GL. Amaral MD, et al. Methods Mol Biol. 2011;741:213-8. doi: 10.1007/978-1-61779-117-8_14. Methods Mol Biol. 2011. PMID: 21594787

17

Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.

Sousa M, Servidoni MF, Vinagre AM, Ramalho AS, Bonadia LC, Felício V, Ribeiro MA, Uliyakina I, Marson FA, Kmit A, Cardoso SR, Ribeiro JD, Bertuzzo CS, Sousa L, Kunzelmann K, Ribeiro AF, Amaral MD. Sousa M, et al. Among authors: amaral md. PLoS One. 2012;7(10):e47708. doi: 10.1371/journal.pone.0047708. Epub 2012 Oct 17. PLoS One. 2012. PMID: 23082198 Free PMC article.

18

Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis.

Amaral MD, Farinha CM. Amaral MD, et al. Curr Pharm Des. 2013;19(19):3497-508. doi: 10.2174/13816128113199990318. Curr Pharm Des. 2013. PMID: 23331027 Review.

19

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies.

Clarke LA, Sousa L, Barreto C, Amaral MD. Clarke LA, et al. Among authors: amaral md. Respir Res. 2013 Mar 28;14(1):38. doi: 10.1186/1465-9921-14-38. Respir Res. 2013. PMID: 23537407 Free PMC article.

20

Post-translational modifications of CFTR: insight into protein trafficking and cystic fibrosis disease.

Amaral MD, Farinha CM. Amaral MD, et al. FEBS J. 2013 Sep;280(18):4395. doi: 10.1111/febs.12345. Epub 2013 Jul 5. FEBS J. 2013. PMID: 23680006 Free article. No abstract available.

21

Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction.

Farinha CM, King-Underwood J, Sousa M, Correia AR, Henriques BJ, Roxo-Rosa M, Da Paula AC, Williams J, Hirst S, Gomes CM, Amaral MD. Farinha CM, et al. Among authors: amaral md. Chem Biol. 2013 Jul 25;20(7):943-55. doi: 10.1016/j.chembiol.2013.06.004. Chem Biol. 2013. PMID: 23890012

22

Assessing the residual CFTR gene expression in human nasal epithelium cells bearing CFTR splicing mutations causing cystic fibrosis.

Masvidal L, Igreja S, Ramos MD, Alvarez A, de Gracia J, Ramalho A, Amaral MD, Larriba S, Casals T. Masvidal L, et al. Among authors: amaral md. Eur J Hum Genet. 2014 Jun;22(6):784-91. doi: 10.1038/ejhg.2013.238. Epub 2013 Oct 16. Eur J Hum Genet. 2014. PMID: 24129438 Free PMC article.

23

LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.

Luz S, Cihil KM, Brautigan DL, Amaral MD, Farinha CM, Swiatecka-Urban A. Luz S, et al. Among authors: amaral md. J Biol Chem. 2014 May 23;289(21):15080-93. doi: 10.1074/jbc.M114.563742. Epub 2014 Apr 11. J Biol Chem. 2014. PMID: 24727471 Free PMC article.

24

CFTR functional measurements in human models for diagnosis, prognosis and personalized therapy: Report on the pre-conference meeting to the 11th ECFS Basic Science Conference, Malta, 26-29 March 2014.

Beekman JM, Sermet-Gaudelus I, de Boeck K, Gonska T, Derichs N, Mall MA, Mehta A, Martin U, Drumm M, Amaral MD. Beekman JM, et al. Among authors: amaral md. J Cyst Fibros. 2014 Jul;13(4):363-72. doi: 10.1016/j.jcf.2014.05.007. Epub 2014 Jun 2. J Cyst Fibros. 2014. PMID: 24882694 Free article. Review. No abstract available.

25

New pharmacological approaches for cystic fibrosis: promises, progress, pitfalls.

Bell SC, De Boeck K, Amaral MD. Bell SC, et al. Among authors: amaral md. Pharmacol Ther. 2015 Jan;145:19-34. doi: 10.1016/j.pharmthera.2014.06.005. Epub 2014 Jun 14. Pharmacol Ther. 2015. PMID: 24932877

26

Comparative ex vivo, in vitro and in silico analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations.

Ramalho AS, Clarke LA, Sousa M, Felicio V, Barreto C, Lopes C, Amaral MD. Ramalho AS, et al. Among authors: amaral md. J Cyst Fibros. 2016 Jan;15(1):21-33. doi: 10.1016/j.jcf.2015.02.002. Epub 2015 Feb 27. J Cyst Fibros. 2016. PMID: 25735457 Free article.

27

A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint.

Loureiro CA, Matos AM, Dias-Alves Â, Pereira JF, Uliyakina I, Barros P, Amaral MD, Matos P. Loureiro CA, et al. Among authors: amaral md. Sci Signal. 2015 May 19;8(377):ra48. doi: 10.1126/scisignal.aaa1580. Sci Signal. 2015. PMID: 25990958

28

Cystic fibrosis -- From basic science to clinical benefit: A review series.

Hartl D, Amaral M. Hartl D, et al. J Cyst Fibros. 2015 Jul;14(4):415-6. doi: 10.1016/j.jcf.2015.06.001. Epub 2015 Jun 15. J Cyst Fibros. 2015. PMID: 26088670 Free article. No abstract available.

29

Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators.

Clarke LA, Botelho HM, Sousa L, Falcao AO, Amaral MD. Clarke LA, et al. Among authors: amaral md. Genomics. 2015 Nov;106(5):268-77. doi: 10.1016/j.ygeno.2015.07.005. Epub 2015 Jul 29. Genomics. 2015. PMID: 26225835 Free article.

30

Hallmarks of therapeutic management of the cystic fibrosis functional landscape.

Amaral MD, Balch WE. Amaral MD, et al. J Cyst Fibros. 2015 Nov;14(6):687-99. doi: 10.1016/j.jcf.2015.09.006. Epub 2015 Oct 29. J Cyst Fibros. 2015. PMID: 26526359 Free PMC article. Review.

31

Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides.

Igreja S, Clarke LA, Botelho HM, Marques L, Amaral MD. Igreja S, et al. Among authors: amaral md. Hum Mutat. 2016 Feb;37(2):209-15. doi: 10.1002/humu.22931. Epub 2015 Dec 2. Hum Mutat. 2016. PMID: 26553470

32

Progress in therapies for cystic fibrosis.

De Boeck K, Amaral MD. De Boeck K, et al. Among authors: amaral md. Lancet Respir Med. 2016 Aug;4(8):662-674. doi: 10.1016/S2213-2600(16)00023-0. Epub 2016 Apr 1. Lancet Respir Med. 2016. PMID: 27053340 Review.

33

mRNA-based detection of rare CFTR mutations improves genetic diagnosis of cystic fibrosis in populations with high genetic heterogeneity.

Felício V, Ramalho AS, Igreja S, Amaral MD. Felício V, et al. Among authors: amaral md. Clin Genet. 2017 Mar;91(3):476-481. doi: 10.1111/cge.12802. Epub 2016 Jun 1. Clin Genet. 2017. PMID: 27174726

34

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1.

Lobo MJ, Amaral MD, Zaccolo M, Farinha CM. Lobo MJ, et al. Among authors: amaral md. J Cell Sci. 2016 Jul 1;129(13):2599-612. doi: 10.1242/jcs.185629. Epub 2016 May 20. J Cell Sci. 2016. PMID: 27206858

35

Classification of CFTR mutation classes - Authors' reply.

De Boeck K, Amaral MD. De Boeck K, et al. Among authors: amaral md. Lancet Respir Med. 2016 Aug;4(8):e39. doi: 10.1016/S2213-2600(16)30189-8. Epub 2016 Jul 1. Lancet Respir Med. 2016. PMID: 27377413 No abstract available.

36

Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).

Amaral MD, Farinha CM, Matos P, Botelho HM. Amaral MD, et al. Methods Mol Biol. 2016;1459:105-26. doi: 10.1007/978-1-4939-3804-9_7. Methods Mol Biol. 2016. PMID: 27665554

37

Epithelial Chloride Transport by CFTR Requires TMEM16A.

Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Benedetto R, et al. Sci Rep. 2017 Sep 29;7(1):12397. doi: 10.1038/s41598-017-10910-0. Sci Rep. 2017. PMID: 28963502 Free PMC article.

38

Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.

Liu J, Bihler H, Farinha CM, Awatade NT, Romão AM, Mercadante D, Cheng Y, Musisi I, Jantarajit W, Wang Y, Cai Z, Amaral MD, Mense M, Sheppard DN. Liu J, et al. Among authors: amaral md. Br J Pharmacol. 2018 Apr;175(7):1017-1038. doi: 10.1111/bph.14141. Epub 2018 Feb 22. Br J Pharmacol. 2018. PMID: 29318594 Free PMC article.

39

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1.

Lérias J, Pinto M, Benedetto R, Schreiber R, Amaral M, Aureli M, Kunzelmann K. Lérias J, et al. Cell Signal. 2018 Apr;44:10-19. doi: 10.1016/j.cellsig.2018.01.008. Epub 2018 Jan 10. Cell Signal. 2018. PMID: 29331508

40

CFTR modulator theratyping: Current status, gaps and future directions.

Clancy JP, Cotton CU, Donaldson SH, Solomon GM, VanDevanter DR, Boyle MP, Gentzsch M, Nick JA, Illek B, Wallenburg JC, Sorscher EJ, Amaral MD, Beekman JM, Naren AP, Bridges RJ, Thomas PJ, Cutting G, Rowe S, Durmowicz AG, Mense M, Boeck KD, Skach W, Penland C, Joseloff E, Bihler H, Mahoney J, Borowitz D, Tuggle KL. Clancy JP, et al. Among authors: amaral md. J Cyst Fibros. 2019 Jan;18(1):22-34. doi: 10.1016/j.jcf.2018.05.004. Epub 2018 Jun 20. J Cyst Fibros. 2019. PMID: 29934203 Free PMC article. Review.

41

R560S: A class II CFTR mutation that is not rescued by current modulators.

Awatade NT, Ramalho S, Silva IAL, Felício V, Botelho HM, de Poel E, Vonk A, Beekman JM, Farinha CM, Amaral MD. Awatade NT, et al. Among authors: amaral md. J Cyst Fibros. 2019 Mar;18(2):182-189. doi: 10.1016/j.jcf.2018.07.001. Epub 2018 Jul 18. J Cyst Fibros. 2019. PMID: 30030066 Free article.

42

Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation.

Canato S, Santos JD, Carvalho AS, Aloria K, Amaral MD, Matthiesen R, Falcao AO, Farinha CM. Canato S, et al. Among authors: amaral md. Cell Mol Life Sci. 2018 Dec;75(24):4495-4509. doi: 10.1007/s00018-018-2896-7. Epub 2018 Jul 31. Cell Mol Life Sci. 2018. PMID: 30066085

43

Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR.

Matos AM, Gomes-Duarte A, Faria M, Barros P, Jordan P, Amaral MD, Matos P. Matos AM, et al. Among authors: amaral md. Sci Rep. 2018 Aug 29;8(1):13026. doi: 10.1038/s41598-018-31514-2. Sci Rep. 2018. PMID: 30158635 Free PMC article.

44

The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read-through therapies in cystic fibrosis.

Clarke LA, Awatade NT, Felício VM, Silva IA, Calucho M, Pereira L, Azevedo P, Cavaco J, Barreto C, Bertuzzo C, Gartner S, Beekman J, Amaral MD. Clarke LA, et al. Among authors: amaral md. Hum Mutat. 2019 Mar;40(3):326-334. doi: 10.1002/humu.23692. Epub 2018 Dec 10. Hum Mutat. 2019. PMID: 30488522

45

Increases in cytosolic Ca²⁺ induce dynamin- and calcineurin-dependent internalisation of CFTR.

Patel W, Moore PJ, Sassano MF, Lopes-Pacheco M, Aleksandrov AA, Amaral MD, Tarran R, Gray MA. Patel W, et al. Among authors: amaral md. Cell Mol Life Sci. 2019 Mar;76(5):977-994. doi: 10.1007/s00018-018-2989-3. Epub 2018 Dec 13. Cell Mol Life Sci. 2019. PMID: 30547226 Free PMC article.

46

Extent of rescue of F508del-CFTR function by VX-809 and VX-770 in human nasal epithelial cells correlates with SNP rs7512462 in SLC26A9 gene in F508del/F508del Cystic Fibrosis patients.

Kmit A, Marson FAL, Pereira SV, Vinagre AM, Leite GS, Servidoni MF, Ribeiro JD, Ribeiro AF, Bertuzzo CS, Amaral MD. Kmit A, et al. Among authors: amaral md. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1323-1331. doi: 10.1016/j.bbadis.2019.01.029. Epub 2019 Feb 1. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30716472 Free article.

47

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum.

Santos JD, Canato S, Carvalho AS, Botelho HM, Aloria K, Amaral MD, Matthiesen R, Falcao AO, Farinha CM. Santos JD, et al. Among authors: amaral md. Cells. 2019 Apr 14;8(4):353. doi: 10.3390/cells8040353. Cells. 2019. PMID: 31014000 Free PMC article.

48

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

Matos AM, Pinto FR, Barros P, Amaral MD, Pepperkok R, Matos P. Matos AM, et al. Among authors: amaral md. J Biol Chem. 2019 Sep 6;294(36):13396-13410. doi: 10.1074/jbc.RA119.008738. Epub 2019 Jul 19. J Biol Chem. 2019. PMID: 31324722 Free PMC article.

49

Activating alternative chloride channels to treat CF: Friends or Foes?: Report on the Meeting of the Basic Science Working Group in Dubrovnik, Croatia.

Amaral MD, Beekman JM. Amaral MD, et al. J Cyst Fibros. 2020 Jan;19(1):11-15. doi: 10.1016/j.jcf.2019.10.005. Epub 2019 Oct 31. J Cyst Fibros. 2020. PMID: 31676346 Free article. Review.

50

CFTR processing, trafficking and interactions.

Amaral MD, Hutt DM, Tomati V, Botelho HM, Pedemonte N. Amaral MD, et al. J Cyst Fibros. 2020 Mar;19 Suppl 1:S33-S36. doi: 10.1016/j.jcf.2019.10.017. Epub 2019 Oct 31. J Cyst Fibros. 2020. PMID: 31680043 Free article. Review.

51

What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?

Amaral MD, Quaresma MC, Pankonien I. Amaral MD, et al. Int J Mol Sci. 2020 Apr 29;21(9):3133. doi: 10.3390/ijms21093133. Int J Mol Sci. 2020. PMID: 32365523 Free PMC article. Review.

52

Laboratory biomarkers for lung disease severity and progression in cystic fibrosis.

Bene Z, Fejes Z, Macek M Jr, Amaral MD, Balogh I, Nagy B Jr. Bene Z, et al. Among authors: amaral md. Clin Chim Acta. 2020 Sep;508:277-286. doi: 10.1016/j.cca.2020.05.015. Epub 2020 May 16. Clin Chim Acta. 2020. PMID: 32428503 Free article. Review.

53

Cystic fibrosis drug trial design in the era of CFTR modulators associated with substantial clinical benefit: stakeholders' consensus view.

De Boeck K, Lee T, Amaral M, Drevinek P, Elborn JS, Fajac I, Kerem E, Davies JC. De Boeck K, et al. J Cyst Fibros. 2020 Sep;19(5):688-695. doi: 10.1016/j.jcf.2020.05.012. Epub 2020 Jun 8. J Cyst Fibros. 2020. PMID: 32527602 Free article.

54

Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation.

Santos JD, Pinto FR, Ferreira JF, Amaral MD, Zaccolo M, Farinha CM. Santos JD, et al. Among authors: amaral md. Biochem J. 2020 Jul 17;477(13):2561-2580. doi: 10.1042/BCJ20200287. Biochem J. 2020. PMID: 32573649

55

Characterization of the mechanism of action of RDR01752, a novel corrector of F508del-CFTR.

Lopes-Pacheco M, Silva IAL, Turner MJ, Carlile GW, Sondo E, Thomas DY, Pedemonte N, Hanrahan JW, Amaral MD. Lopes-Pacheco M, et al. Among authors: amaral md. Biochem Pharmacol. 2020 Oct;180:114133. doi: 10.1016/j.bcp.2020.114133. Epub 2020 Jul 3. Biochem Pharmacol. 2020. PMID: 32628927

56

Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions.

Uliyakina I, Botelho HM, da Paula AC, Afonso S, Lobo MJ, Felício V, Farinha CM, Amaral MD. Uliyakina I, et al. Among authors: amaral md. Int J Mol Sci. 2020 Jun 25;21(12):4524. doi: 10.3390/ijms21124524. Int J Mol Sci. 2020. PMID: 32630527 Free PMC article.

57

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway.

Sousa L, Pankonien I, Clarke LA, Silva I, Kunzelmann K, Amaral MD. Sousa L, et al. Among authors: amaral md. Cells. 2020 Jul 2;9(7):1607. doi: 10.3390/cells9071607. Cells. 2020. PMID: 32630830 Free PMC article.

58

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G.

Silva IAL, Doušová T, Ramalho S, Centeio R, Clarke LA, Railean V, Botelho HM, Holubová A, Valášková I, Yeh JT, Hwang TC, Farinha CM, Kunzelmann K, Amaral MD. Silva IAL, et al. Among authors: amaral md. Biochim Biophys Acta Mol Basis Dis. 2020 Nov 1;1866(11):165905. doi: 10.1016/j.bbadis.2020.165905. Epub 2020 Jul 28. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32730979 Free PMC article.

59

Extensive CFTR sequencing through NGS in Brazilian individuals with cystic fibrosis: unravelling regional discrepancies in the country.

da Silva Filho LVRF, Maróstica PJC, Athanazio RA, Reis FJC, Damaceno N, Paes AT, Hira AY, Schlesinger D, Kok F, Amaral MD; Brazilian Cystic Fibrosis Patient Registry Contributors Team. da Silva Filho LVRF, et al. Among authors: amaral md. J Cyst Fibros. 2021 May;20(3):473-484. doi: 10.1016/j.jcf.2020.08.007. Epub 2020 Aug 18. J Cyst Fibros. 2021. PMID: 32819855 Free article.

60

Rescue of common exon-skipping mutations in cystic fibrosis with modified U1 snRNAs.

Donegà S, Rogalska ME, Pianigiani G, Igreja S, Amaral MD, Pagani F. Donegà S, et al. Among authors: amaral md. Hum Mutat. 2020 Dec;41(12):2143-2154. doi: 10.1002/humu.24116. Epub 2020 Oct 14. Hum Mutat. 2020. PMID: 32935393

61

Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis.

Sousa L, Pankonien I, Simões FB, Chanson M, Amaral MD. Sousa L, et al. Among authors: amaral md. Int J Mol Sci. 2020 Sep 14;21(18):6717. doi: 10.3390/ijms21186717. Int J Mol Sci. 2020. PMID: 32937756 Free PMC article.

62

Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition.

Quaresma MC, Pankonien I, Clarke LA, Sousa LS, Silva IAL, Railean V, Doušová T, Fuxe J, Amaral MD. Quaresma MC, et al. Among authors: amaral md. Cell Death Dis. 2020 Oct 26;11(10):920. doi: 10.1038/s41419-020-03119-z. Cell Death Dis. 2020. PMID: 33106471 Free PMC article.

63

Pediatric population with cystic fibrosis in the centre of Portugal: candidates for new therapies.

Roda J, Teixeira T, Ai Silva I, Silva TR, Ferreira R, Amaral MD, Oliveira G. Roda J, et al. Among authors: amaral md. J Pediatr (Rio J). 2022 Mar-Apr;98(2):212-217. doi: 10.1016/j.jped.2021.05.010. Epub 2021 Jul 9. J Pediatr (Rio J). 2022. PMID: 34252371 Free PMC article. Review.

64

Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis.

Clarke LA, Luz VCC, Targowski S, Ramalho SS, Farinha CM, Amaral MD. Clarke LA, et al. Among authors: amaral md. Genes (Basel). 2021 Nov 18;12(11):1810. doi: 10.3390/genes12111810. Genes (Basel). 2021. PMID: 34828417 Free PMC article.

65

Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9.

Pinto MC, Quaresma MC, Silva IAL, Railean V, Ramalho SS, Amaral MD. Pinto MC, et al. Among authors: amaral md. Int J Mol Sci. 2021 Dec 2;22(23):13064. doi: 10.3390/ijms222313064. Int J Mol Sci. 2021. PMID: 34884866 Free PMC article.

66

Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis.

Pinto MC, Botelho HM, Silva IAL, Railean V, Neumann B, Pepperkok R, Schreiber R, Kunzelmann K, Amaral MD. Pinto MC, et al. Among authors: amaral md. J Mol Biol. 2022 Mar 15;434(5):167436. doi: 10.1016/j.jmb.2021.167436. Epub 2022 Jan 3. J Mol Biol. 2022. PMID: 34990652

67

Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies.

Ramalho SS, Silva IAL, Amaral MD, Farinha CM. Ramalho SS, et al. Among authors: amaral md. Int J Mol Sci. 2021 Dec 21;23(1):24. doi: 10.3390/ijms23010024. Int J Mol Sci. 2021. PMID: 35008443 Free PMC article.

68

Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A.

Lopes-Pacheco M, Bacalhau M, Ramalho SS, Silva IAL, Ferreira FC, Carlile GW, Thomas DY, Farinha CM, Hanrahan JW, Amaral MD. Lopes-Pacheco M, et al. Among authors: amaral md. Cells. 2022 Jan 1;11(1):136. doi: 10.3390/cells11010136. Cells. 2022. PMID: 35011698 Free PMC article.

69

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

Lim SH, Snider J, Birimberg-Schwartz L, Ip W, Serralha JC, Botelho HM, Lopes-Pacheco M, Pinto MC, Moutaoufik MT, Zilocchi M, Laselva O, Esmaeili M, Kotlyar M, Lyakisheva A, Tang P, López Vázquez L, Akula I, Aboualizadeh F, Wong V, Grozavu I, Opacak-Bernardi T, Yao Z, Mendoza M, Babu M, Jurisica I, Gonska T, Bear CE, Amaral MD, Stagljar I. Lim SH, et al. Among authors: amaral md. Mol Syst Biol. 2022 Feb;18(2):e10629. doi: 10.15252/msb.202110629. Mol Syst Biol. 2022. PMID: 35156780 Free PMC article.

70

CFTR, Cell Junctions and the Cytoskeleton.

Pankonien I, Quaresma MC, Rodrigues CS, Amaral MD. Pankonien I, et al. Among authors: amaral md. Int J Mol Sci. 2022 Feb 28;23(5):2688. doi: 10.3390/ijms23052688. Int J Mol Sci. 2022. PMID: 35269829 Free PMC article. Review.

71

Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial-mesenchymal transition.

Quaresma MC, Botelho HM, Pankonien I, Rodrigues CS, Pinto MC, Costa PR, Duarte A, Amaral MD. Quaresma MC, et al. Among authors: amaral md. Life Sci Alliance. 2022 May 2;5(9):e202101326. doi: 10.26508/lsa.202101326. Print 2022 Sep. Life Sci Alliance. 2022. PMID: 35500936 Free PMC article.

72

Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids.

Ferreira JF, Silva IAL, Botelho HM, Amaral MD, Farinha CM. Ferreira JF, et al. Among authors: amaral md. Cells. 2022 Jul 25;11(15):2295. doi: 10.3390/cells11152295. Cells. 2022. PMID: 35892592 Free PMC article.

73

Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids.

Rodenburg LW, Delpiano L, Railean V, Centeio R, Pinto MC, Smits SMA, van der Windt IS, van Hugten CFJ, van Beuningen SFB, Rodenburg RNP, van der Ent CK, Amaral MD, Kunzelmann K, Gray MA, Beekman JM, Amatngalim GD. Rodenburg LW, et al. Among authors: amaral md. Int J Mol Sci. 2022 Oct 21;23(20):12657. doi: 10.3390/ijms232012657. Int J Mol Sci. 2022. PMID: 36293514 Free PMC article.

74

Identification of novel F508del-CFTR traffic correctors among triazole derivatives.

Bacalhau M, Ferreira FC, Kmit A, Souza FR, da Silva VD, Pimentel AS, Amaral MD, Buarque CD, Lopes-Pacheco M. Bacalhau M, et al. Among authors: amaral md. Eur J Pharmacol. 2023 Jan 5;938:175396. doi: 10.1016/j.ejphar.2022.175396. Epub 2022 Nov 19. Eur J Pharmacol. 2023. PMID: 36410419 Free article.

75

PTI-801 (posenacaftor) shares a common mechanism with VX-445 (elexacaftor) to rescue p.Phe508del-CFTR.

Ferreira FC, Amaral MD, Bacalhau M, Lopes-Pacheco M. Ferreira FC, et al. Among authors: amaral md. Eur J Pharmacol. 2024 Mar 15;967:176390. doi: 10.1016/j.ejphar.2024.176390. Epub 2024 Feb 8. Eur J Pharmacol. 2024. PMID: 38336013 Free article.

76

Complex cystic fibrosis allele R334W-R1158X results in reduced levels of correctly processed mRNA in a pancreatic sufficient patient.

Duarte A, Amaral M, Barreto C, Pacheco P, Lavinha J. Duarte A, et al. Hum Mutat. 1996;8(2):134-9. doi: 10.1002/(SICI)1098-1004(1996)8:2<134::AID-HUMU5>3.0.CO;2-B. Hum Mutat. 1996. PMID: 8844211

77

Cystic fibrosis patients with the 3272-26A-->G mutation have mild disease, leaky alternative mRNA splicing, and CFTR protein at the cell membrane.

Beck S, Penque D, Garcia S, Gomes A, Farinha C, Mata L, Gulbenkian S, Gil-Ferreira K, Duarte A, Pacheco P, Barreto C, Lopes B, Cavaco J, Lavinha J, Amaral MD. Beck S, et al. Among authors: amaral md. Hum Mutat. 1999;14(2):133-44. doi: 10.1002/(SICI)1098-1004(1999)14:2<133::AID-HUMU5>3.0.CO;2-T. Hum Mutat. 1999. PMID: 10425036

78

Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis.

Ramalho AS, Beck S, Meyer M, Penque D, Cutting GR, Amaral MD. Ramalho AS, et al. Among authors: amaral md. Am J Respir Cell Mol Biol. 2002 Nov;27(5):619-27. doi: 10.1165/rcmb.2001-0004OC. Am J Respir Cell Mol Biol. 2002. PMID: 12397022

79

Transcript analysis of the cystic fibrosis splicing mutation 1525-1G>A shows use of multiple alternative splicing sites and suggests a putative role of exonic splicing enhancers.

Ramalho AS, Beck S, Penque D, Gonska T, Seydewitz HH, Mall M, Amaral MD. Ramalho AS, et al. Among authors: amaral md. J Med Genet. 2003 Jul;40(7):e88. doi: 10.1136/jmg.40.7.e88. J Med Genet. 2003. PMID: 12843337 Free PMC article. No abstract available.

80

CFTR localization in native airway cells and cell lines expressing wild-type or F508del-CFTR by a panel of different antibodies.

Carvalho-Oliveira I, Efthymiadou A, Malhó R, Nogueira P, Tzetis M, Kanavakis E, Amaral MD, Penque D. Carvalho-Oliveira I, et al. Among authors: amaral md. J Histochem Cytochem. 2004 Feb;52(2):193-203. doi: 10.1177/002215540405200207. J Histochem Cytochem. 2004. PMID: 14729871

81

Assessment of CFTR function in native epithelia for the diagnosis of cystic fibrosis.

Barreto C, Mall M, Amaral MD. Barreto C, et al. Among authors: amaral md. Pediatr Pulmonol Suppl. 2004;26:243. doi: 10.1002/ppul.70118. Pediatr Pulmonol Suppl. 2004. PMID: 15029663 No abstract available.

82

A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein.

Farinha CM, Mendes F, Roxo-Rosa M, Penque D, Amaral MD. Farinha CM, et al. Among authors: amaral md. Mol Cell Probes. 2004 Aug;18(4):235-42. doi: 10.1016/j.mcp.2004.03.005. Mol Cell Probes. 2004. PMID: 15271383

83

Immunohistochemistry of CFTR in native tissues and primary epithelial cell cultures.

Mendes F, Doucet L, Hinzpeter A, Férec C, Lipecka J, Fritsch J, Edelman A, Jorna H, Willemsen R, Bot AG, De Jonge HR, Hinnrasky J, Castillon N, Taouil K, Puchelle E, Penque D, Amaral MD. Mendes F, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:37-41. doi: 10.1016/j.jcf.2004.05.008. J Cyst Fibros. 2004. PMID: 15463923 Free article. Review.

84

Biochemical methods to assess CFTR expression and membrane localization.

Farinha CM, Penque D, Roxo-Rosa M, Lukacs G, Dormer R, McPherson M, Pereira M, Bot AG, Jorna H, Willemsen R, Dejonge H, Heda GD, Marino CR, Fanen P, Hinzpeter A, Lipecka J, Fritsch J, Gentzsch M, Edelman A, Amaral MD. Farinha CM, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:73-7. doi: 10.1016/j.jcf.2004.05.017. J Cyst Fibros. 2004. PMID: 15463932 Free article.

85

Proteomics techniques for cystic fibrosis research.

Roxo-Rosa M, Davezac N, Bensalem N, Majumder M, Heda GD, Simas A, Penque D, Amaral MD, Lukacs GL, Edelman A. Roxo-Rosa M, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:85-9. doi: 10.1016/j.jcf.2004.05.019. J Cyst Fibros. 2004. PMID: 15463934 Free article. Review.

86

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.

Farinha CM, Amaral MD. Farinha CM, et al. Among authors: amaral md. Mol Cell Biol. 2005 Jun;25(12):5242-52. doi: 10.1128/MCB.25.12.5242-5252.2005. Mol Cell Biol. 2005. PMID: 15923638 Free PMC article.

87

Characterization of novel airway submucosal gland cell models for cystic fibrosis studies.

da Paula AC, Ramalho AS, Farinha CM, Cheung J, Maurisse R, Gruenert DC, Ousingsawat J, Kunzelmann K, Amaral MD. da Paula AC, et al. Among authors: amaral md. Cell Physiol Biochem. 2005;15(6):251-62. doi: 10.1159/000087235. Cell Physiol Biochem. 2005. PMID: 16037690 Free article.

88

Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies.

Mendes F, Wakefield J, Bachhuber T, Barroso M, Bebok Z, Penque D, Kunzelmann K, Amaral MD. Mendes F, et al. Among authors: amaral md. Cell Physiol Biochem. 2005;16(4-6):281-90. doi: 10.1159/000089857. Cell Physiol Biochem. 2005. PMID: 16301828 Free article.

89

Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms.

Roxo-Rosa M, Xu Z, Schmidt A, Neto M, Cai Z, Soares CM, Sheppard DN, Amaral MD. Roxo-Rosa M, et al. Among authors: amaral md. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17891-6. doi: 10.1073/pnas.0608312103. Epub 2006 Nov 10. Proc Natl Acad Sci U S A. 2006. PMID: 17098864 Free PMC article.

90

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.

Schmidt A, Hughes LK, Cai Z, Mendes F, Li H, Sheppard DN, Amaral MD. Schmidt A, et al. Among authors: amaral md. Br J Pharmacol. 2008 Mar;153(6):1311-23. doi: 10.1038/sj.bjp.0707663. Epub 2008 Jan 28. Br J Pharmacol. 2008. PMID: 18223673 Free PMC article.

91

Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone.

Scott-Ward TS, Amaral MD. Scott-Ward TS, et al. Among authors: amaral md. FEBS J. 2009 Dec;276(23):7097-109. doi: 10.1111/j.1742-4658.2009.07421.x. Epub 2009 Oct 29. FEBS J. 2009. PMID: 19878303 Free article.

92

Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.

Luz S, Kongsuphol P, Mendes AI, Romeiras F, Sousa M, Schreiber R, Matos P, Jordan P, Mehta A, Amaral MD, Kunzelmann K, Farinha CM. Luz S, et al. Among authors: amaral md. Mol Cell Biol. 2011 Nov;31(22):4392-404. doi: 10.1128/MCB.05517-11. Epub 2011 Sep 19. Mol Cell Biol. 2011. PMID: 21930781 Free PMC article.

93

CFTR biomarkers: time for promotion to surrogate end-point.

De Boeck K, Kent L, Davies J, Derichs N, Amaral M, Rowe SM, Middleton P, de Jonge H, Bronsveld I, Wilschanski M, Melotti P, Danner-Boucher I, Boerner S, Fajac I, Southern K, de Nooijer RA, Bot A, de Rijke Y, de Wachter E, Leal T, Vermeulen F, Hug MJ, Rault G, Nguyen-Khoa T, Barreto C, Proesmans M, Sermet-Gaudelus I; European Cystic Fibrosis Society Clinical Trial Network Standardisation Committee. De Boeck K, et al. Eur Respir J. 2013 Jan;41(1):203-16. doi: 10.1183/09031936.00057512. Epub 2012 Aug 9. Eur Respir J. 2013. PMID: 22878883 Free article. Review.

94

HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic fibrosis mutant F508del-CFTR.

Moniz S, Sousa M, Moraes BJ, Mendes AI, Palma M, Barreto C, Fragata JI, Amaral MD, Matos P. Moniz S, et al. Among authors: amaral md. ACS Chem Biol. 2013 Feb 15;8(2):432-42. doi: 10.1021/cb300484r. Epub 2012 Nov 20. ACS Chem Biol. 2013. PMID: 23148778

95

BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner.

Mendes F, Farinha CM, Felício V, Alves PC, Vieira I, Amaral MD. Mendes F, et al. Among authors: amaral md. Cell Physiol Biochem. 2012;30(5):1120-33. doi: 10.1159/000343303. Epub 2012 Oct 5. Cell Physiol Biochem. 2012. PMID: 23178238 Free article.

96

Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi.

Farinha CM, Matos P, Amaral MD. Farinha CM, et al. Among authors: amaral md. FEBS J. 2013 Sep;280(18):4396-406. doi: 10.1111/febs.12392. Epub 2013 Jul 5. FEBS J. 2013. PMID: 23773658 Free article. Review.

97

Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients.

Amaral MD. Amaral MD. J Intern Med. 2015 Feb;277(2):155-166. doi: 10.1111/joim.12314. J Intern Med. 2015. PMID: 25266997 Free article. Review.

98

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

Botelho HM, Uliyakina I, Awatade NT, Proença MC, Tischer C, Sirianant L, Kunzelmann K, Pepperkok R, Amaral MD. Botelho HM, et al. Among authors: amaral md. Sci Rep. 2015 Mar 12;5:9038. doi: 10.1038/srep09038. Sci Rep. 2015. PMID: 25762484 Free PMC article.

99

Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis.

Awatade NT, Uliyakina I, Farinha CM, Clarke LA, Mendes K, Solé A, Pastor J, Ramos MM, Amaral MD. Awatade NT, et al. Among authors: amaral md. EBioMedicine. 2014 Dec 17;2(2):147-53. doi: 10.1016/j.ebiom.2014.12.005. eCollection 2015. EBioMedicine. 2014. PMID: 26137539 Free PMC article.

100

Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015.

Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Verkman AS, et al. J Cyst Fibros. 2015 Nov;14(6):700-5. doi: 10.1016/j.jcf.2015.10.001. Epub 2015 Oct 21. J Cyst Fibros. 2015. PMID: 26474804 Free PMC article. No abstract available.

101

Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis.

Nagy B Jr, Nagy B, Fila L, Clarke LA, Gönczy F, Bede O, Nagy D, Újhelyi R, Szabó Á, Anghelyi A, Major M, Bene Z, Fejes Z, Antal-Szalmás P, Bhattoa HP, Balla G, Kappelmayer J, Amaral MD, Macek M Jr, Balogh I. Nagy B Jr, et al. Among authors: amaral md. Chest. 2016 Sep;150(3):661-72. doi: 10.1016/j.chest.2016.04.006. Epub 2016 Apr 19. Chest. 2016. PMID: 27105680

102

Ethnicity impacts the cystic fibrosis diagnosis: A note of caution.

Bosch B, Bilton D, Sosnay P, Raraigh KS, Mak DYF, Ishiguro H, Gulmans V, Thomas M, Cuppens H, Amaral M, De Boeck K. Bosch B, et al. J Cyst Fibros. 2017 Jul;16(4):488-491. doi: 10.1016/j.jcf.2017.01.016. Epub 2017 Feb 21. J Cyst Fibros. 2017. PMID: 28233695 Free article.

103

Biobanking: towards increased access of biomaterials in cystic fibrosis. Report on the pre-conference meeting to the 13th ECFS Basic Science Conference, Pisa, 30 March-2 April, 2016.

Beekman JM, Wang CM, Casati S, Tuggle KL, Gulmans VAM, Amaral M, De Boeck K. Beekman JM, et al. J Cyst Fibros. 2017 Sep;16(5):616-621. doi: 10.1016/j.jcf.2017.04.009. Epub 2017 May 3. J Cyst Fibros. 2017. PMID: 28478961 Free article. No abstract available.

104

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD. Lérias JR, et al. Among authors: amaral md. Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29154949 Free article.

105

A Mathematical Model of the Phosphoinositide Pathway.

Olivença DV, Uliyakina I, Fonseca LL, Amaral MD, Voit EO, Pinto FR. Olivença DV, et al. Among authors: amaral md. Sci Rep. 2018 Mar 2;8(1):3904. doi: 10.1038/s41598-018-22226-8. Sci Rep. 2018. PMID: 29500467 Free PMC article.

106

Cystic fibrosis: Beyond the airways. Report on the meeting of the basic science working group in Loutraki, Greece.

Amaral MD, Boj SF, Shaw J, Leipziger J, Beekman JM. Amaral MD, et al. J Cyst Fibros. 2018 Jul;17(4):441-443. doi: 10.1016/j.jcf.2018.05.008. Epub 2018 Jun 2. J Cyst Fibros. 2018. PMID: 29866530 Free article. Review.

107

Human epididymis protein 4 (HE4) levels inversely correlate with lung function improvement (delta FEV₁) in cystic fibrosis patients receiving ivacaftor treatment.

Nagy B Jr, Bene Z, Fejes Z, Heltshe SL, Reid D, Ronan NJ, McCarthy Y, Smith D, Nagy A, Joseloff E, Balla G, Kappelmayer J, Macek M Jr, Bell SC, Plant BJ, Amaral MD, Balogh I. Nagy B Jr, et al. Among authors: amaral md. J Cyst Fibros. 2019 Mar;18(2):271-277. doi: 10.1016/j.jcf.2018.08.013. Epub 2018 Sep 27. J Cyst Fibros. 2019. PMID: 30268371 Free article.

108

Speeding up access to new drugs for CF: Considerations for clinical trial design and delivery.

Davies JC, Drevinek P, Elborn JS, Kerem E, Lee T; European CF Society (ECFS) Strategic Planning Task Force on ‘Speeding up access to new 4 drugs for CF’; Amaral MD, de Boeck K, Davies JC, Drevinek P, Elborn JS, Kerem E, Lee T. Davies JC, et al. Among authors: amaral md. J Cyst Fibros. 2019 Sep;18(5):677-684. doi: 10.1016/j.jcf.2019.06.011. Epub 2019 Jul 11. J Cyst Fibros. 2019. PMID: 31303382 Free article.

109

Theranostics by testing CFTR modulators in patient-derived materials: The current status and a proposal for subjects with rare CFTR mutations.

Amaral MD, de Boeck K; ECFS Strategic Planning Task Force on ‘Speeding up access to new drugs for CF’. Amaral MD, et al. J Cyst Fibros. 2019 Sep;18(5):685-692. doi: 10.1016/j.jcf.2019.06.010. Epub 2019 Jul 17. J Cyst Fibros. 2019. PMID: 31326274 Free article.

110

TMEM16A chloride channel does not drive mucus production.

Simões FB, Quaresma MC, Clarke LA, Silva IA, Pankonien I, Railean V, Kmit A, Amaral MD. Simões FB, et al. Among authors: amaral md. Life Sci Alliance. 2019 Nov 15;2(6):e201900462. doi: 10.26508/lsa.201900462. Print 2019 Dec. Life Sci Alliance. 2019. PMID: 31732694 Free PMC article.

111

Letter to the editor of JCF.

Amaral MD. Amaral MD. J Cyst Fibros. 2020 May;19(3):503. doi: 10.1016/j.jcf.2020.02.011. J Cyst Fibros. 2020. PMID: 32600655 Free article. No abstract available.

112

Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids.

Vonk AM, van Mourik P, Ramalho AS, Silva IAL, Statia M, Kruisselbrink E, Suen SWF, Dekkers JF, Vleggaar FP, Houwen RHJ, Mullenders J, Boj SF, Vries R, Amaral MD, de Boeck K, van der Ent CK, Beekman JM. Vonk AM, et al. Among authors: amaral md. STAR Protoc. 2020 Jun 3;1(1):100019. doi: 10.1016/j.xpro.2020.100019. eCollection 2020 Jun 19. STAR Protoc. 2020. PMID: 33111074 Free PMC article.

113

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids.

Silva IAL, Railean V, Duarte A, Amaral MD. Silva IAL, et al. Among authors: amaral md. J Pers Med. 2021 May 16;11(5):421. doi: 10.3390/jpm11050421. J Pers Med. 2021. PMID: 34065744 Free PMC article.

114

Precision medicine for rare diseases: The times they are A-Changin'.

Amaral MD. Amaral MD. Curr Opin Pharmacol. 2022 Apr;63:102201. doi: 10.1016/j.coph.2022.102201. Epub 2022 Mar 4. Curr Opin Pharmacol. 2022. PMID: 35255452 Review.

115

The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion.

Jo S, Centeio R, Park J, Ousingsawat J, Jeon DK, Talbi K, Schreiber R, Ryu K, Kahlenberg K, Somoza V, Delpiano L, Gray MA, Amaral MD, Railean V, Beekman JM, Rodenburg LW, Namkung W, Kunzelmann K. Jo S, et al. Among authors: amaral md. FASEB J. 2022 Nov;36(11):e22534. doi: 10.1096/fj.202200313RR. FASEB J. 2022. PMID: 36183361

116

Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators.

Railean V, Rodrigues CS, Ramalho SS, Silva IAL, Bartosch J, Farinha CM, Pankonien I, Amaral MD. Railean V, et al. Among authors: amaral md. Front Mol Biosci. 2023 Mar 17;10:1155705. doi: 10.3389/fmolb.2023.1155705. eCollection 2023. Front Mol Biosci. 2023. PMID: 37006619 Free PMC article.

117

Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells.

Penque D, Mendes F, Beck S, Farinha C, Pacheco P, Nogueira P, Lavinha J, Malhó R, Amaral MD. Penque D, et al. Among authors: amaral md. Lab Invest. 2000 Jun;80(6):857-68. doi: 10.1038/labinvest.3780090. Lab Invest. 2000. PMID: 10879737 Free article.

118

Unusually common cystic fibrosis mutation in Portugal encodes a misprocessed protein.

Mendes F, Roxo Rosa M, Dragomir A, Farinha CM, Roomans GM, Amaral MD, Penque D. Mendes F, et al. Among authors: amaral md. Biochem Biophys Res Commun. 2003 Nov 21;311(3):665-71. doi: 10.1016/j.bbrc.2003.10.048. Biochem Biophys Res Commun. 2003. PMID: 14623323

119

Analysis of genomic CFTR DNA.

Férec C, Le Maréchal C, Audrézet MP, Farinha CM, Amaral MD, Gallati S, Sanz J, Steiner B, Mouchel N, Harris A, Schwarz MJ. Férec C, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:7-10. doi: 10.1016/j.jcf.2004.05.003. J Cyst Fibros. 2004. PMID: 15463917 Free article. Review.

120

Non-PCR methods for the analysis of CFTR transcripts.

Trezise AE, Farinha CM, Heda GD, Harris A, Amaral MD, Mouchel N. Trezise AE, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:25-8. doi: 10.1016/j.jcf.2004.05.005. J Cyst Fibros. 2004. PMID: 15463920 Free article. Review.

121

CFTR mutations altering CFTR fragmentation.

Tosoni K, Stobbart M, Cassidy DM, Venerando A, Pagano MA, Luz S, Amaral MD, Kunzelmann K, Pinna LA, Farinha CM, Mehta A. Tosoni K, et al. Among authors: amaral md. Biochem J. 2013 Jan 1;449(1):295-305. doi: 10.1042/BJ20121240. Biochem J. 2013. PMID: 23067305 Free PMC article.

122

High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.

Almaça J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Heriché JK, Huber W, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD. Almaça J, et al. Among authors: amaral md. Cell. 2013 Sep 12;154(6):1390-400. doi: 10.1016/j.cell.2013.08.045. Cell. 2013. PMID: 24034256 Free article.

123

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR.

Farinha CM, Sousa M, Canato S, Schmidt A, Uliyakina I, Amaral MD. Farinha CM, et al. Among authors: amaral md. Pharmacol Res Perspect. 2015 Aug;3(4):e00152. doi: 10.1002/prp2.152. Epub 2015 Jun 11. Pharmacol Res Perspect. 2015. PMID: 26171232 Free PMC article.

124

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis.

Pinto MC, Silva IAL, Figueira MF, Amaral MD, Lopes-Pacheco M. Pinto MC, et al. Among authors: amaral md. J Exp Pharmacol. 2021 Jul 23;13:693-723. doi: 10.2147/JEP.S255377. eCollection 2021. J Exp Pharmacol. 2021. PMID: 34326672 Free PMC article. Review.

125

Using the genome to correct the ion transport defect in cystic fibrosis.

Amaral MD. Amaral MD. J Physiol. 2023 May;601(9):1573-1582. doi: 10.1113/JP282308. Epub 2022 Sep 30. J Physiol. 2023. PMID: 36068724

126

Development of novel therapeutics for all individuals with CF (the future goes on).

Amaral MD, Harrison PT. Amaral MD, et al. J Cyst Fibros. 2023 Mar;22 Suppl 1:S45-S49. doi: 10.1016/j.jcf.2022.10.007. Epub 2022 Oct 30. J Cyst Fibros. 2023. PMID: 36319570 Review.

127

Human epididymis protein 4 (HE4) plasma concentration inversely correlates with the improvement of cystic fibrosis lung disease in p.Phe508del-CFTR homozygous cases treated with the CFTR modulator lumacaftor/ivacaftor combination.

Pócsi M, Fejes Z, Bene Z, Nagy A, Balogh I, Amaral MD, Macek M Jr, Nagy B Jr. Pócsi M, et al. Among authors: amaral md. J Cyst Fibros. 2023 Nov;22(6):1085-1092. doi: 10.1016/j.jcf.2023.04.001. Epub 2023 Apr 20. J Cyst Fibros. 2023. PMID: 37087300 Free article.

128

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70.

Farinha CM, Nogueira P, Mendes F, Penque D, Amaral MD. Farinha CM, et al. Among authors: amaral md. Biochem J. 2002 Sep 15;366(Pt 3):797-806. doi: 10.1042/BJ20011717. Biochem J. 2002. PMID: 12069690 Free PMC article.

129

CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis.

Hirtz S, Gonska T, Seydewitz HH, Thomas J, Greiner P, Kuehr J, Brandis M, Eichler I, Rocha H, Lopes AI, Barreto C, Ramalho A, Amaral MD, Kunzelmann K, Mall M. Hirtz S, et al. Among authors: amaral md. Gastroenterology. 2004 Oct;127(4):1085-95. doi: 10.1053/j.gastro.2004.07.006. Gastroenterology. 2004. PMID: 15480987

130

Proteomic analysis of nasal cells from cystic fibrosis patients and non-cystic fibrosis control individuals: search for novel biomarkers of cystic fibrosis lung disease.

Roxo-Rosa M, da Costa G, Luider TM, Scholte BJ, Coelho AV, Amaral MD, Penque D. Roxo-Rosa M, et al. Among authors: amaral md. Proteomics. 2006 Apr;6(7):2314-25. doi: 10.1002/pmic.200500273. Proteomics. 2006. PMID: 16518875

131

Microarray mRNA expression profiling to study cystic fibrosis.

Ramachandran S, Clarke LA, Scheetz TE, Amaral MD, McCray PB Jr. Ramachandran S, et al. Among authors: amaral md. Methods Mol Biol. 2011;742:193-212. doi: 10.1007/978-1-61779-120-8_12. Methods Mol Biol. 2011. PMID: 21547734

132

Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth.

Li H, Yang W, Mendes F, Amaral MD, Sheppard DN. Li H, et al. Among authors: amaral md. Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1176-86. doi: 10.1152/ajprenal.00130.2012. Epub 2012 Aug 8. Am J Physiol Renal Physiol. 2012. PMID: 22874761 Free article.

133

An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay.

Hagemeijer MC, Vonk AM, Awatade NT, Silva IAL, Tischer C, Hilsenstein V, Beekman JM, Amaral MD, Botelho HM. Hagemeijer MC, et al. Among authors: amaral md. Bioinformatics. 2021 Apr 5;36(24):5686-5694. doi: 10.1093/bioinformatics/btaa1073. Bioinformatics. 2021. PMID: 33367496

134

CyFi-MAP: an interactive pathway-based resource for cystic fibrosis.

Pereira C, Mazein A, Farinha CM, Gray MA, Kunzelmann K, Ostaszewski M, Balaur I, Amaral MD, Falcao AO. Pereira C, et al. Among authors: amaral md. Sci Rep. 2021 Nov 15;11(1):22223. doi: 10.1038/s41598-021-01618-3. Sci Rep. 2021. PMID: 34782688 Free PMC article.

135

Additive Potentiation of R334W-CFTR Function by Novel Small Molecules.

Bacalhau M, Ferreira FC, Silva IAL, Buarque CD, Amaral MD, Lopes-Pacheco M. Bacalhau M, et al. Among authors: amaral md. J Pers Med. 2023 Jan 1;13(1):102. doi: 10.3390/jpm13010102. J Pers Med. 2023. PMID: 36675763 Free PMC article.

136

Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells.

Santos L, Nascimento R, Duarte A, Railean V, Amaral MD, Harrison PT, Gama-Carvalho M, Farinha CM. Santos L, et al. Among authors: amaral md. Cell Biosci. 2023 Feb 9;13(1):26. doi: 10.1186/s13578-023-00975-y. Cell Biosci. 2023. PMID: 36759923 Free PMC article.

137

Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing.

Harris CM, Mendes F, Dragomir A, Doull IJ, Carvalho-Oliveira I, Bebok Z, Clancy JP, Eubanks V, Sorscher EJ, Roomans GM, Amaral MD, McPherson MA, Penque D, Dormer RL. Harris CM, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:43-8. doi: 10.1016/j.jcf.2004.05.009. J Cyst Fibros. 2004. PMID: 15463924 Free article. Review.

138

Escherichia coli-cloned CFTR loci relevant for human artificial chromosome therapy.

Rocchi L, Braz C, Cattani S, Ramalho A, Christan S, Edlinger M, Ascenzioni F, Laner A, Kraner S, Amaral M, Schindelhauer D. Rocchi L, et al. Hum Gene Ther. 2010 Sep;21(9):1077-92. doi: 10.1089/hum.2009.225. Hum Gene Ther. 2010. PMID: 20384480

139

Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR.

Xu Z, Pissarra LS, Farinha CM, Liu J, Cai Z, Thibodeau PH, Amaral MD, Sheppard DN. Xu Z, et al. Among authors: amaral md. J Physiol. 2014 May 1;592(9):1931-47. doi: 10.1113/jphysiol.2014.271817. Epub 2014 Mar 3. J Physiol. 2014. PMID: 24591578 Free PMC article.

140

Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells.

Bene Z, Fejes Z, Szanto TG, Fenyvesi F, Váradi J, Clarke LA, Panyi G, Macek M Jr, Amaral MD, Balogh I, Nagy B Jr. Bene Z, et al. Among authors: amaral md. Front Pharmacol. 2021 May 14;12:592184. doi: 10.3389/fphar.2021.592184. eCollection 2021. Front Pharmacol. 2021. PMID: 34054511 Free PMC article.

141

Applicability of different antibodies for the immunohistochemical localization of CFTR in respiratory and intestinal tissues of human and murine origin.

Doucet L, Mendes F, Montier T, Delépine P, Penque D, Férec C, Amaral MD. Doucet L, et al. Among authors: amaral md. J Histochem Cytochem. 2003 Sep;51(9):1191-9. doi: 10.1177/002215540305100909. J Histochem Cytochem. 2003. PMID: 12923244

142

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene.

Sosnay PR, Siklosi KR, Van Goor F, Kaniecki K, Yu H, Sharma N, Ramalho AS, Amaral MD, Dorfman R, Zielenski J, Masica DL, Karchin R, Millen L, Thomas PJ, Patrinos GP, Corey M, Lewis MH, Rommens JM, Castellani C, Penland CM, Cutting GR. Sosnay PR, et al. Among authors: amaral md. Nat Genet. 2013 Oct;45(10):1160-7. doi: 10.1038/ng.2745. Epub 2013 Aug 25. Nat Genet. 2013. PMID: 23974870 Free PMC article.

143

What Can RNA-Based Therapy Do for Monogenic Diseases?

Clarke LA, Amaral MD. Clarke LA, et al. Among authors: amaral md. Pharmaceutics. 2023 Jan 12;15(1):260. doi: 10.3390/pharmaceutics15010260. Pharmaceutics. 2023. PMID: 36678889 Free PMC article. Review.

144

An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis.

Sousa M, Ousingsawat J, Seitz R, Puntheeranurak S, Regalado A, Schmidt A, Grego T, Jansakul C, Amaral MD, Schreiber R, Kunzelmann K. Sousa M, et al. Among authors: amaral md. Mol Pharmacol. 2007 Jan;71(1):366-76. doi: 10.1124/mol.106.025262. Epub 2006 Oct 25. Mol Pharmacol. 2007. PMID: 17065237

145

CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector.

Rakonczay Z Jr, Hegyi P, Hasegawa M, Inoue M, You J, Iida A, Ignáth I, Alton EW, Griesenbach U, Ovári G, Vág J, Da Paula AC, Crawford RM, Varga G, Amaral MD, Mehta A, Lonovics J, Argent BE, Gray MA. Rakonczay Z Jr, et al. Among authors: amaral md. J Cell Physiol. 2008 Feb;214(2):442-55. doi: 10.1002/jcp.21220. J Cell Physiol. 2008. PMID: 17654517

146

F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis.

Martins JR, Kongsuphol P, Sammels E, Dahimène S, Aldehni F, Clarke LA, Schreiber R, de Smedt H, Amaral MD, Kunzelmann K. Martins JR, et al. Among authors: amaral md. Biochim Biophys Acta. 2011 Nov;1812(11):1385-92. doi: 10.1016/j.bbadis.2011.08.008. Epub 2011 Aug 30. Biochim Biophys Acta. 2011. PMID: 21907281 Free article.

147

Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility.

Servidoni MF, Sousa M, Vinagre AM, Cardoso SR, Ribeiro MA, Meirelles LR, de Carvalho RB, Kunzelmann K, Ribeiro AF, Ribeiro JD, Amaral MD. Servidoni MF, et al. Among authors: amaral md. BMC Gastroenterol. 2013 May 20;13:91. doi: 10.1186/1471-230X-13-91. BMC Gastroenterol. 2013. PMID: 23688510 Free PMC article.

148

The third dimension: new developments in cell culture models for colorectal research.

Pereira JF, Awatade NT, Loureiro CA, Matos P, Amaral MD, Jordan P. Pereira JF, et al. Among authors: amaral md. Cell Mol Life Sci. 2016 Nov;73(21):3971-89. doi: 10.1007/s00018-016-2258-2. Epub 2016 May 4. Cell Mol Life Sci. 2016. PMID: 27147463 Review.

149

A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles.

Almeida C, Amaral MD. Almeida C, et al. Among authors: amaral md. Cell Mol Life Sci. 2020 Dec;77(23):4729-4745. doi: 10.1007/s00018-020-03523-w. Epub 2020 Apr 20. Cell Mol Life Sci. 2020. PMID: 32313974 Review.

150

Assessment of Distinct Electrophysiological Parameters in Rectal Biopsies for the Choice of the Best Diagnosis/Prognosis Biomarkers for Cystic Fibrosis.

Silva IAL, Duarte A, Marson FAL, Centeio R, Doušová T, Kunzelmann K, Amaral MD. Silva IAL, et al. Among authors: amaral md. Front Physiol. 2020 Dec 23;11:604580. doi: 10.3389/fphys.2020.604580. eCollection 2020. Front Physiol. 2020. PMID: 33424627 Free PMC article.

151

Cystic fibrosis patients with the 3272-26A>G splicing mutation have milder disease than F508del homozygotes: a large European study.

Amaral MD, Pacheco P, Beck S, Farinha CM, Penque D, Nogueira P, Barreto C, Lopes B, Casals T, Dapena J, Gartner S, Vásquez C, Pérez-Frías J, Olveira C, Cabanas R, Estivill X, Tzetis M, Kanavakis E, Doudounakis S, Dörk T, Tümmler B, Girodon-Boulandet E, Cazeneuve C, Goossens M, Blayau M, Verlingue C, Vieira I, Féréc C, Claustres M, des Georges M, Clavel C, Birembaut P, Hubert D, Bienvenu T, Adoun M, Chomel JC, De Boeck K, Cuppens H, Lavinha J. Amaral MD, et al. J Med Genet. 2001 Nov;38(11):777-83. doi: 10.1136/jmg.38.11.777. J Med Genet. 2001. PMID: 11732487 Free PMC article. No abstract available.

152

Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei.

Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D. Zink D, et al. Among authors: amaral md. J Cell Biol. 2004 Sep 13;166(6):815-25. doi: 10.1083/jcb.200404107. J Cell Biol. 2004. PMID: 15364959 Free PMC article.

153

Microarray analysis in cystic fibrosis.

Galvin P, Clarke LA, Harvey S, Amaral MD. Galvin P, et al. Among authors: amaral md. J Cyst Fibros. 2004 Aug;3 Suppl 2:29-33. doi: 10.1016/j.jcf.2004.05.006. J Cyst Fibros. 2004. PMID: 15463921 Free article. Review.

154

The replication timing of CFTR and adjacent genes.

Englmann A, Clarke LA, Christan S, Amaral MD, Schindelhauer D, Zink D. Englmann A, et al. Among authors: amaral md. Chromosome Res. 2005;13(2):183-94. doi: 10.1007/s10577-005-0845-4. Chromosome Res. 2005. PMID: 15861307

155

Bacterial transfer of large functional genomic DNA into human cells.

Laner A, Goussard S, Ramalho AS, Schwarz T, Amaral MD, Courvalin P, Schindelhauer D, Grillot-Courvalin C. Laner A, et al. Among authors: amaral md. Gene Ther. 2005 Nov;12(21):1559-72. doi: 10.1038/sj.gt.3302576. Gene Ther. 2005. PMID: 15973438

156

Ionic transport in tall columnar epithelial (TCE) cells obtained by nasal brushing from non-cystic fibrosis (CF) individuals.

Maurício AC, Penque D, Amaral MD, Ferreira KT. Maurício AC, et al. Among authors: amaral md. Acta Med Port. 2004 Nov-Dec;17(6):427-34. Epub 2005 Jan 18. Acta Med Port. 2004. PMID: 16197854 Free article.

157

Regulation of the epithelial Na+ channel by the protein kinase CK2.

Bachhuber T, Almaça J, Aldehni F, Mehta A, Amaral MD, Schreiber R, Kunzelmann K. Bachhuber T, et al. Among authors: amaral md. J Biol Chem. 2008 May 9;283(19):13225-32. doi: 10.1074/jbc.M704532200. Epub 2008 Feb 28. J Biol Chem. 2008. PMID: 18308722 Free PMC article.

158

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated.

Almaça J, Kongsuphol P, Hieke B, Ousingsawat J, Viollet B, Schreiber R, Amaral MD, Kunzelmann K. Almaça J, et al. Among authors: amaral md. Pflugers Arch. 2009 Aug;458(4):713-21. doi: 10.1007/s00424-009-0660-4. Epub 2009 Mar 31. Pflugers Arch. 2009. PMID: 19333618

159

Effect of Annexin A5 on CFTR: regulated traffic or scaffolding?

Faria D, Dahimène S, Alessio L, Scott-Ward T, Schreiber R, Kunzelmann K, Amaral MD. Faria D, et al. Among authors: amaral md. Mol Membr Biol. 2011 Jan;28(1):14-29. doi: 10.3109/09687688.2010.506264. Epub 2010 Nov 11. Mol Membr Biol. 2011. PMID: 21067452

160

Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase.

Mendes AI, Matos P, Moniz S, Luz S, Amaral MD, Farinha CM, Jordan P. Mendes AI, et al. Among authors: amaral md. Mol Cell Biol. 2011 Oct;31(19):4076-86. doi: 10.1128/MCB.05152-11. Epub 2011 Aug 1. Mol Cell Biol. 2011. PMID: 21807898 Free PMC article.

161

The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.

Roth EK, Hirtz S, Duerr J, Wenning D, Eichler I, Seydewitz HH, Amaral MD, Mall MA. Roth EK, et al. Among authors: amaral md. PLoS One. 2011;6(8):e24445. doi: 10.1371/journal.pone.0024445. Epub 2011 Aug 31. PLoS One. 2011. PMID: 21909392 Free PMC article.

162

Regulation of ENaC biogenesis by the stress response protein SERP1.

Faria D, Lentze N, Almaça J, Luz S, Alessio L, Tian Y, Martins JP, Cruz P, Schreiber R, Rezwan M, Farinha CM, Auerbach D, Amaral MD, Kunzelmann K. Faria D, et al. Among authors: amaral md. Pflugers Arch. 2012 Jun;463(6):819-27. doi: 10.1007/s00424-012-1091-1. Epub 2012 Apr 19. Pflugers Arch. 2012. PMID: 22526458

163

Control of TMEM16A by INO-4995 and other inositolphosphates.

Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, Palma M, Faria D, Traynor-Kaplan AE, Fragata JI, Amaral MD, Kunzelmann K. Tian Y, et al. Among authors: amaral md. Br J Pharmacol. 2013 Jan;168(1):253-65. doi: 10.1111/j.1476-5381.2012.02193.x. Br J Pharmacol. 2013. PMID: 22946960 Free PMC article.

164

Experimental assessment of splicing variants using expression minigenes and comparison with in silico predictions.

Sharma N, Sosnay PR, Ramalho AS, Douville C, Franca A, Gottschalk LB, Park J, Lee M, Vecchio-Pagan B, Raraigh KS, Amaral MD, Karchin R, Cutting GR. Sharma N, et al. Among authors: amaral md. Hum Mutat. 2014 Oct;35(10):1249-59. doi: 10.1002/humu.22624. Epub 2014 Sep 10. Hum Mutat. 2014. PMID: 25066652 Free PMC article.

165

Relationship between TMEM16A/anoctamin 1 and LRRC8A.

Benedetto R, Sirianant L, Pankonien I, Wanitchakool P, Ousingsawat J, Cabrita I, Schreiber R, Amaral M, Kunzelmann K. Benedetto R, et al. Pflugers Arch. 2016 Oct;468(10):1751-63. doi: 10.1007/s00424-016-1862-1. Epub 2016 Aug 12. Pflugers Arch. 2016. PMID: 27514381

166

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation.

Pinto MC, Schreiber R, Lerias J, Ousingsawat J, Duarte A, Amaral M, Kunzelmann K. Pinto MC, et al. Cells. 2020 May 5;9(5):1138. doi: 10.3390/cells9051138. Cells. 2020. PMID: 32380794 Free PMC article.

167

Cystic Fibrosis Newborn Screening in Portugal: PAP Value in Populations with Stringent Rules for Genetic Studies.

Marcão A, Barreto C, Pereira L, Vaz LG, Cavaco J, Casimiro A, Félix M, Silva TR, Barbosa T, Freitas C, Nunes S, Felício V, Lopes L, Amaral M, Vilarinho L. Marcão A, et al. Int J Neonatal Screen. 2018 Jun 29;4(3):22. doi: 10.3390/ijns4030022. eCollection 2018 Sep. Int J Neonatal Screen. 2018. PMID: 33072945 Free PMC article.

168

Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways.

Davidson H, McLachlan G, Wilson A, Boyd AC, Doherty A, MacGregor G, Davies L, Painter HA, Coles R, Hyde SC, Gill DR, Amaral MD, Collie DD, Porteous DJ, Penque D. Davidson H, et al. Among authors: amaral md. Am J Respir Cell Mol Biol. 2006 Jul;35(1):72-83. doi: 10.1165/rcmb.2005-0377OC. Epub 2006 Feb 23. Am J Respir Cell Mol Biol. 2006. PMID: 16498081

169

Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR.

Scott-Ward TS, Cai Z, Dawson ES, Doherty A, Da Paula AC, Davidson H, Porteous DJ, Wainwright BJ, Amaral MD, Sheppard DN, Boyd AC. Scott-Ward TS, et al. Among authors: amaral md. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16365-70. doi: 10.1073/pnas.0701562104. Epub 2007 Oct 3. Proc Natl Acad Sci U S A. 2007. PMID: 17913891 Free PMC article.

170

Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target.

Simões FB, Kmit A, Amaral MD. Simões FB, et al. Among authors: amaral md. ERJ Open Res. 2021 Dec 13;7(4):00247-2021. doi: 10.1183/23120541.00247-2021. eCollection 2021 Oct. ERJ Open Res. 2021. PMID: 34912883 Free PMC article.

171

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.

Garcia SM, Casanueva MO, Silva MC, Amaral MD, Morimoto RI. Garcia SM, et al. Among authors: amaral md. Genes Dev. 2007 Nov 15;21(22):3006-16. doi: 10.1101/gad.1575307. Genes Dev. 2007. PMID: 18006691 Free PMC article.

172

A genetic screening strategy identifies novel regulators of the proteostasis network.

Silva MC, Fox S, Beam M, Thakkar H, Amaral MD, Morimoto RI. Silva MC, et al. Among authors: amaral md. PLoS Genet. 2011 Dec;7(12):e1002438. doi: 10.1371/journal.pgen.1002438. Epub 2011 Dec 29. PLoS Genet. 2011. PMID: 22242008 Free PMC article.

173

Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response.

Silva MC, Amaral MD, Morimoto RI. Silva MC, et al. Among authors: amaral md. PLoS Genet. 2013 Aug;9(8):e1003711. doi: 10.1371/journal.pgen.1003711. Epub 2013 Aug 29. PLoS Genet. 2013. PMID: 24009518 Free PMC article.

174

Crystallization and preliminary X-ray diffraction analysis of protein L-isoaspartyl O-methyltransferase from wheat germ.

Amaral MD, Chen L, Chattopadhyay D, Smith CD, Meehan EJ. Amaral MD, et al. Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):304-5. doi: 10.1107/s0907444900017030. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11173488

175

GET-UP Trial 1-year results: long-term impact of an early mobilization protocol on functional performance after surgery for chronic subdural hematoma.

Pinto V, Sousa SA, Vaz da Silva F, Ribeiro da Costa T, Fernandes AP, Batata R, Noronha C, Monteiro Silva J, Ferreira S, Sobral S, Alves C, Rangel R, Calheiros A; GET-UP Trial Collaborators. Pinto V, et al. J Neurosurg. 2023 Nov 10:1-8. doi: 10.3171/2023.8.JNS231509. Online ahead of print. J Neurosurg. 2023. PMID: 37948693

176

Parents' Perspectives on the Utility of Genomic Sequencing in the Neonatal Intensive Care Unit.

Lemke AA, Thompson ML, Gimpel EC, McNamara KC, Rich CA, Finnila CR, Cochran ME, Lawlor JMJ, East KM, Bowling KM, Latner DR, Hiatt SM, Amaral MD, Kelley WV, Greve V, Gray DE, Felker SA, Meddaugh H, Cannon A, Luedecke A, Jackson KE, Hendon LG, Janani HM, Johnston M, Merin LA, Deans SL, Tuura C, Hughes T, Williams H, Laborde K, Neu MB, Patrick-Esteve J, Hurst ACE, Kirmse BM, Savich R, Spedale SB, Knight SJ, Barsh GS, Korf BR, Cooper GM, Brothers KB. Lemke AA, et al. Among authors: amaral md. J Pers Med. 2023 Jun 21;13(7):1026. doi: 10.3390/jpm13071026. J Pers Med. 2023. PMID: 37511639 Free PMC article.

177

Contributions of rare and common variation to early-onset and atypical dementia risk.

Wright CA, Taylor JW, Cochran M, Lawlor JMJ, Moyers BA, Amaral MD, Bonnstetter ZT, Carter P, Solomon V, Myers RM, Love MN, Geldmacher DS, Cooper SJ, Roberson ED, Cochran JN. Wright CA, et al. Among authors: amaral md. Cold Spring Harb Mol Case Stud. 2023 Jul 11;9(3):a006271. doi: 10.1101/mcs.a006271. Print 2023 Jun. Cold Spring Harb Mol Case Stud. 2023. PMID: 37308299 Free PMC article.

178

Impact of an early mobilization protocol on the reduction of medical complications after surgery for chronic subdural hematoma: the GET-UP Trial.

Sousa S, Pinto V, Vaz da Silva F, Ribeiro da Costa T, Fernandes A, Batata R, Noronha C, Monteiro Silva J, Ferreira S, Sobral S, Alves C, Rangel R, Calheiros A; GET-UP Trial Collaborators. Sousa S, et al. J Neurosurg. 2023 Mar 17;139(3):854-863. doi: 10.3171/2023.2.JNS222262. Print 2023 Sep 1. J Neurosurg. 2023. PMID: 36933251 Clinical Trial.

179

Contributions of rare and common variation to early-onset and atypical dementia risk.

Wright CA, Taylor JW, Cochran M, Lawlor JMJ, Moyers BA, Amaral MD, Bonnstetter ZT, Carter P, Solomon V, Myers RM, Love MN, Geldmacher DS, Cooper SJ, Roberson ED, Cochran JN. Wright CA, et al. Among authors: amaral md. medRxiv [Preprint]. 2023 Feb 8:2023.02.06.23285383. doi: 10.1101/2023.02.06.23285383. medRxiv. 2023. PMID: 36798301 Free PMC article. Updated. Preprint.

180

Phenology, floral and reproductive biology of Dichorisandra rhizantha Aona (Commelinaceae), an endemic endangered species in an Atlantic Forest fragment.

de Almeida Junior RAC, de Souza EH, da Costa GM, Rossi ML, Bittrich V, Amaral MDCED, Aona LYS. de Almeida Junior RAC, et al. Among authors: amaral mdced. Microsc Res Tech. 2023 May;86(5):573-588. doi: 10.1002/jemt.24296. Epub 2023 Jan 27. Microsc Res Tech. 2023. PMID: 36704938

181

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.

Amatngalim GD, Rodenburg LW, Aalbers BL, Raeven HH, Aarts EM, Sarhane D, Spelier S, Lefferts JW, Silva IA, Nijenhuis W, Vrendenbarg S, Kruisselbrink E, Brunsveld JE, van Drunen CM, Michel S, de Winter-de Groot KM, Heijerman HG, Kapitein LC, Amaral MD, van der Ent CK, Beekman JM. Amatngalim GD, et al. Among authors: amaral md. Life Sci Alliance. 2022 Aug 3;5(12):e202101320. doi: 10.26508/lsa.202101320. Life Sci Alliance. 2022. PMID: 35922154 Free PMC article.

182

The first complete plastome of Mimusops coriacea (A. DC.) Miq. (Sapotaceae).

Trad RJ, Silva SRD, Amaral MDCED. Trad RJ, et al. Genet Mol Biol. 2022 Jan 24;45(1):e20210174. doi: 10.1590/1678-4685-GMB-2021-0174. eCollection 2022. Genet Mol Biol. 2022. PMID: 35098966 Free PMC article.

183

Genome sequencing as a first-line diagnostic test for hospitalized infants.

Bowling KM, Thompson ML, Finnila CR, Hiatt SM, Latner DR, Amaral MD, Lawlor JMJ, East KM, Cochran ME, Greve V, Kelley WV, Gray DE, Felker SA, Meddaugh H, Cannon A, Luedecke A, Jackson KE, Hendon LG, Janani HM, Johnston M, Merin LA, Deans SL, Tuura C, Williams H, Laborde K, Neu MB, Patrick-Esteve J, Hurst ACE, Kandasamy J, Carlo W, Brothers KB, Kirmse BM, Savich R, Superneau D, Spedale SB, Knight SJ, Barsh GS, Korf BR, Cooper GM. Bowling KM, et al. Among authors: amaral md. Genet Med. 2022 Apr;24(4):851-861. doi: 10.1016/j.gim.2021.11.020. Epub 2021 Nov 27. Genet Med. 2022. PMID: 34930662 Free PMC article.

184

Calophyllaceae plastomes, their structure and insights in relationships within the clusioids.

Trad RJ, Cabral FN, Bittrich V, Silva SRD, Amaral MDCED. Trad RJ, et al. Sci Rep. 2021 Oct 20;11(1):20712. doi: 10.1038/s41598-021-99178-z. Sci Rep. 2021. PMID: 34671062 Free PMC article.

185

Phylogeny, divergence times, and diversification in Calophyllaceae: Linking key characters and habitat changes to the evolution of Neotropical Calophylleae.

Cabral FN, Trad RJ, Amorim BS, Maciel JR, Amaral MDCED, Stevens P. Cabral FN, et al. Mol Phylogenet Evol. 2021 Apr;157:107041. doi: 10.1016/j.ympev.2020.107041. Epub 2021 Jan 18. Mol Phylogenet Evol. 2021. PMID: 33476719 Free article.

186

Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple congenital abnormalities.

Snijders Blok L, Vino A, den Hoed J, Underhill HR, Monteil D, Li H, Reynoso Santos FJ, Chung WK, Amaral MD, Schnur RE, Santiago-Sim T, Si Y, Brunner HG, Kleefstra T, Fisher SE. Snijders Blok L, et al. Among authors: amaral md. Genet Med. 2021 Mar;23(3):534-542. doi: 10.1038/s41436-020-01016-6. Epub 2020 Oct 28. Genet Med. 2021. PMID: 33110267 Free PMC article.

187

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.

Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS; Alzheimer’s Disease Neuroimaging Initiative. Cochran JN, et al. Among authors: amaral md. Am J Hum Genet. 2020 May 7;106(5):632-645. doi: 10.1016/j.ajhg.2020.03.010. Epub 2020 Apr 23. Am J Hum Genet. 2020. PMID: 32330418 Free PMC article.

188

Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.

Cochran JN, McKinley EC, Cochran M, Amaral MD, Moyers BA, Lasseigne BN, Gray DE, Lawlor JMJ, Prokop JW, Geier EG, Holt JM, Thompson ML, Newberry JS, Yokoyama JS, Worthey EA, Geldmacher DS, Love MN, Cooper GM, Myers RM, Roberson ED. Cochran JN, et al. Among authors: amaral md. Cold Spring Harb Mol Case Stud. 2019 Dec 13;5(6):a003491. doi: 10.1101/mcs.a003491. Print 2019 Dec. Cold Spring Harb Mol Case Stud. 2019. PMID: 31836585 Free PMC article.

189

Child Neurology: Spastic paraparesis and dystonia with a novel ADCY5 mutation.

Dean M, Messiaen L, Cooper GM, Amaral MD, Rashid S, Korf BR, Standaert DG. Dean M, et al. Among authors: amaral md. Neurology. 2019 Sep 10;93(11):510-514. doi: 10.1212/WNL.0000000000008089. Neurology. 2019. PMID: 31501304 Free PMC article. No abstract available.

190

Genomic sequencing identifies secondary findings in a cohort of parent study participants.

Thompson ML, Finnila CR, Bowling KM, Brothers KB, Neu MB, Amaral MD, Hiatt SM, East KM, Gray DE, Lawlor JMJ, Kelley WV, Lose EJ, Rich CA, Simmons S, Levy SE, Myers RM, Barsh GS, Bebin EM, Cooper GM. Thompson ML, et al. Among authors: amaral md. Genet Med. 2018 Dec;20(12):1635-1643. doi: 10.1038/gim.2018.53. Epub 2018 Apr 12. Genet Med. 2018. PMID: 29790872 Free PMC article.

191

Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.

Liu N, Schoch K, Luo X, Pena LDM, Bhavana VH, Kukolich MK, Stringer S, Powis Z, Radtke K, Mroske C, Deak KL, McDonald MT, McConkie-Rosell A, Markert ML, Kranz PG, Stong N, Need AC, Bick D, Amaral MD, Worthey EA, Levy S; Undiagnosed Diseases Network (UDN); Wangler MF, Bellen HJ, Shashi V, Yamamoto S. Liu N, et al. Among authors: amaral md. Hum Mol Genet. 2018 Jul 15;27(14):2454-2465. doi: 10.1093/hmg/ddy146. Hum Mol Genet. 2018. PMID: 29726930 Free PMC article.

192

Systematic reanalysis of genomic data improves quality of variant interpretation.

Hiatt SM, Amaral MD, Bowling KM, Finnila CR, Thompson ML, Gray DE, Lawlor JMJ, Cochran JN, Bebin EM, Brothers KB, East KM, Kelley WV, Lamb NE, Levy SE, Lose EJ, Neu MB, Rich CA, Simmons S, Myers RM, Barsh GS, Cooper GM. Hiatt SM, et al. Among authors: amaral md. Clin Genet. 2018 Jul;94(1):174-178. doi: 10.1111/cge.13259. Epub 2018 May 10. Clin Genet. 2018. PMID: 29652076 Free PMC article.

193

Evaluation of the acaricidal activity of thymol incorporated in two formulations for topical use against immature stages of Rhipicephalus sanguineus sensu lato (Latreille, 1806) (Acari: Ixodidae).

Delmonte C, Cruz PB, Zeringóta V, de Mello V, Ferreira F, Amaral MDPH, Daemon E. Delmonte C, et al. Parasitol Res. 2017 Nov;116(11):2957-2964. doi: 10.1007/s00436-017-5604-x. Epub 2017 Sep 5. Parasitol Res. 2017. PMID: 28875304

194

Genomic diagnosis for children with intellectual disability and/or developmental delay.

Bowling KM, Thompson ML, Amaral MD, Finnila CR, Hiatt SM, Engel KL, Cochran JN, Brothers KB, East KM, Gray DE, Kelley WV, Lamb NE, Lose EJ, Rich CA, Simmons S, Whittle JS, Weaver BT, Nesmith AS, Myers RM, Barsh GS, Bebin EM, Cooper GM. Bowling KM, et al. Among authors: amaral md. Genome Med. 2017 May 30;9(1):43. doi: 10.1186/s13073-017-0433-1. Genome Med. 2017. PMID: 28554332 Free PMC article.

195

Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium.

Amendola LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y, Amaral MD, Berg JS, Biswas S, Bowling KM, Conlin LK, Cooper GM, Dorschner MO, Dulik MC, Ghazani AA, Ghosh R, Green RC, Hart R, Horton C, Johnston JJ, Lebo MS, Milosavljevic A, Ou J, Pak CM, Patel RY, Punj S, Richards CS, Salama J, Strande NT, Yang Y, Plon SE, Biesecker LG, Rehm HL. Amendola LM, et al. Among authors: amaral md. Am J Hum Genet. 2016 Jul 7;99(1):247. doi: 10.1016/j.ajhg.2016.06.001. Am J Hum Genet. 2016. PMID: 27392081 Free PMC article. No abstract available.

196

Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium.

Amendola LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y, Amaral MD, Berg JS, Biswas S, Bowling KM, Conlin LK, Cooper GM, Dorschner MO, Dulik MC, Ghazani AA, Ghosh R, Green RC, Hart R, Horton C, Johnston JJ, Lebo MS, Milosavljevic A, Ou J, Pak CM, Patel RY, Punj S, Richards CS, Salama J, Strande NT, Yang Y, Plon SE, Biesecker LG, Rehm HL. Amendola LM, et al. Among authors: amaral md. Am J Hum Genet. 2016 Jun 2;98(6):1067-1076. doi: 10.1016/j.ajhg.2016.03.024. Epub 2016 May 12. Am J Hum Genet. 2016. PMID: 27181684 Free PMC article.

197

Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels.

Leuner K, Li W, Amaral MD, Rudolph S, Calfa G, Schuwald AM, Harteneck C, Inoue T, Pozzo-Miller L. Leuner K, et al. Among authors: amaral md. Hippocampus. 2013 Jan;23(1):40-52. doi: 10.1002/hipo.22052. Epub 2012 Jul 20. Hippocampus. 2013. PMID: 22815087 Free PMC article.

198

Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release.

Amaral MD, Pozzo-Miller L. Amaral MD, et al. Neural Plast. 2012;2012:203536. doi: 10.1155/2012/203536. Epub 2012 Jul 3. Neural Plast. 2012. PMID: 22811938 Free PMC article.

199

New clinical diagnostic procedures for cystic fibrosis in Europe.

De Boeck K, Derichs N, Fajac I, de Jonge HR, Bronsveld I, Sermet I, Vermeulen F, Sheppard DN, Cuppens H, Hug M, Melotti P, Middleton PG, Wilschanski M; ECFS Diagnostic Network Working Group; EuroCareCF WP3 Group on CF diagnosis. De Boeck K, et al. J Cyst Fibros. 2011 Jun;10 Suppl 2:S53-66. doi: 10.1016/S1569-1993(11)60009-X. J Cyst Fibros. 2011. PMID: 21658643 Free article. Review.

200

Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons.

Li Y, Calfa G, Inoue T, Amaral MD, Pozzo-Miller L. Li Y, et al. Among authors: amaral md. J Neurophysiol. 2010 May;103(5):2846-56. doi: 10.1152/jn.01140.2009. Epub 2010 Mar 10. J Neurophysiol. 2010. PMID: 20220070 Free PMC article.

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