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Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.
Theilmann AL, Hawke LG, Hilton LR, Whitford MKM, Cole DV, Mackeil JL, Dunham-Snary KJ, Mewburn J, James PD, Maurice DH, Archer SL, Ormiston ML. Theilmann AL, et al. Among authors: archer sl. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2605-2618. doi: 10.1161/ATVBAHA.119.313357. Epub 2020 Oct 1. Arterioscler Thromb Vasc Biol. 2020. PMID: 32998516 Free PMC article.
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.
Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL. Xiong PY, et al. Among authors: archer sl. Front Cardiovasc Med. 2019 Jan 25;5:195. doi: 10.3389/fcvm.2018.00195. eCollection 2018. Front Cardiovasc Med. 2019. PMID: 30740395 Free PMC article.
Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada.
Wijeratne DT, Lajkosz K, Brogly SB, Lougheed MD, Jiang L, Housin A, Barber D, Johnson A, Doliszny KM, Archer SL. Wijeratne DT, et al. Among authors: archer sl. Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e003973. doi: 10.1161/CIRCOUTCOMES.117.003973. Circ Cardiovasc Qual Outcomes. 2018. PMID: 29444925 Free PMC article.
MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.
Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL. Hong Z, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2017 Feb 15;195(4):515-529. doi: 10.1164/rccm.201604-0814OC. Am J Respir Crit Care Med. 2017. PMID: 27648837 Free PMC article.
Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease.
Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F. Ranchoux B, et al. Among authors: archer sl. Circ Res. 2019 Aug 2;125(4):449-466. doi: 10.1161/CIRCRESAHA.118.314555. Epub 2019 Jun 3. Circ Res. 2019. PMID: 31154939
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.
Dasgupta A, Chen KH, Wu D, Hoskin V, Mewburn J, Lima PDA, Parlow LRG, Hindmarch CCT, Martin A, Sykes EA, Tayade C, Lightbody ED, Madarnas Y, SenGupta SK, Elliott BE, Nicol CJB, Archer SL. Dasgupta A, et al. Among authors: archer sl. FASEB J. 2020 Apr;34(4):5106-5127. doi: 10.1096/fj.201903117R. Epub 2020 Feb 18. FASEB J. 2020. PMID: 32068312
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PDA, Hong Z, Zhao YY, Hindmarch CCT, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL. Tian L, et al. Among authors: archer sl. Circ Res. 2020 Jun 5;126(12):1723-1745. doi: 10.1161/CIRCRESAHA.120.316443. Epub 2020 Mar 27. Circ Res. 2020. PMID: 32216531 Free PMC article.
Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site IQ Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus.
Read AD, Bentley RET, Martin AY, Mewburn JD, Alizadeh E, Wu D, Lima PDA, Dunham-Snary KJ, Thébaud B, Sharp W, Archer SL. Read AD, et al. Among authors: archer sl. J Am Heart Assoc. 2023 Jul 4;12(13):e029131. doi: 10.1161/JAHA.122.029131. Epub 2023 Jun 22. J Am Heart Assoc. 2023. PMID: 37345832 Free PMC article.
A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.
Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E. Kuebler WM, et al. Among authors: archer sl. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L502-L516. doi: 10.1152/ajplung.00150.2018. Epub 2018 Jun 7. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29877097 Free PMC article. Review.
Right ventricular adaptation and failure in pulmonary arterial hypertension.
Ryan JJ, Huston J, Kutty S, Hatton ND, Bowman L, Tian L, Herr JE, Johri AM, Archer SL. Ryan JJ, et al. Among authors: archer sl. Can J Cardiol. 2015 Apr;31(4):391-406. doi: 10.1016/j.cjca.2015.01.023. Epub 2015 Jan 29. Can J Cardiol. 2015. PMID: 25840092 Free PMC article. Review.
Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.
Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Hemnes AR, et al. Among authors: archer sl. Circulation. 2015 Jan 27;131(4):401-9; discussion 409. doi: 10.1161/CIRCULATIONAHA.114.013317. Epub 2014 Oct 31. Circulation. 2015. PMID: 25361553 Free PMC article.
Novel Drp1 GTPase Inhibitor, Drpitor1a: Efficacy in Pulmonary Hypertension.
Wu D, Jansen-van Vuuren RD, Dasgupta A, Al-Qazazi R, Chen KH, Martin AY, Mewburn JD, Alizadeh E, Lima PDA, Jones O, Colpman P, Bentley RET, VandenBroek MM, Breault NM, Emon IM, Yerramilli VS, Jedlovčnik L, Zhao YY, Wells M, Sutendra G, Ormiston ML, Archer SL. Wu D, et al. Among authors: archer sl. Hypertension. 2024 Oct;81(10):2189-2201. doi: 10.1161/HYPERTENSIONAHA.124.22822. Epub 2024 Aug 20. Hypertension. 2024. PMID: 39162036
Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension.
Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Hemnes AR, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2016 Aug 15;194(4):464-75. doi: 10.1164/rccm.201508-1678OC. Am J Respir Crit Care Med. 2016. PMID: 26926454 Free PMC article.
Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases.
Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB 4th, Provencher S, Zhang L, Uchida S. Bonnet S, et al. Among authors: archer sl. Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C1-C28. doi: 10.1152/ajpcell.00078.2019. Epub 2019 Sep 4. Am J Physiol Cell Physiol. 2020. PMID: 31483703 Free PMC article. Review.
Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension.
Potus F, Pauciulo MW, Cook EK, Zhu N, Hsieh A, Welch CL, Shen Y, Tian L, Lima P, Mewburn J, D'Arsigny CL, Lutz KA, Coleman AW, Damico R, Snetsinger B, Martin AY, Hassoun PM, Nichols WC, Chung WK, Rauh MJ, Archer SL. Potus F, et al. Among authors: archer sl. Circulation. 2020 Jun 16;141(24):1986-2000. doi: 10.1161/CIRCULATIONAHA.119.044320. Epub 2020 Mar 20. Circulation. 2020. PMID: 32192357 Free PMC article.
Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.
Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL. Chen KH, et al. Among authors: archer sl. Circulation. 2018 Jul 17;138(3):287-304. doi: 10.1161/CIRCULATIONAHA.117.031258. Epub 2018 Feb 5. Circulation. 2018. PMID: 29431643 Free PMC article.
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.
Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thébaud B, Michelakis ED, Archer SL. Kajimoto H, et al. Among authors: archer sl. Circulation. 2007 Apr 3;115(13):1777-88. doi: 10.1161/CIRCULATIONAHA.106.649566. Epub 2007 Mar 12. Circulation. 2007. PMID: 17353442
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL. Dunham-Snary KJ, et al. Among authors: archer sl. Chest. 2017 Jan;151(1):181-192. doi: 10.1016/j.chest.2016.09.001. Epub 2016 Sep 16. Chest. 2017. PMID: 27645688 Free PMC article. Review.
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Wu D, Dasgupta A, Chen KH, Neuber-Hess M, Patel J, Hurst TE, Mewburn JD, Lima PDA, Alizadeh E, Martin A, Wells M, Snieckus V, Archer SL. Wu D, et al. Among authors: archer sl. FASEB J. 2020 Jan;34(1):1447-1464. doi: 10.1096/fj.201901467R. Epub 2019 Dec 2. FASEB J. 2020. PMID: 31914641
Mitochondria in human neutrophils mediate killing of Staphylococcus aureus.
Dunham-Snary KJ, Surewaard BG, Mewburn JD, Bentley RE, Martin AY, Jones O, Al-Qazazi R, Lima PA, Kubes P, Archer SL. Dunham-Snary KJ, et al. Among authors: archer sl. Redox Biol. 2022 Feb;49:102225. doi: 10.1016/j.redox.2021.102225. Epub 2021 Dec 24. Redox Biol. 2022. PMID: 34959099 Free PMC article.
Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function.
Quin C, DeJong EN, Cook EK, Luo YZ, Vlasschaert C, Sadh S, McNaughton AJ, Buttigieg MM, Breznik JA, Kennedy AE, Zhao K, Mewburn J, Dunham-Snary KJ, Hindmarch CC, Bick AG, Archer SL, Rauh MJ, Bowdish DM. Quin C, et al. Among authors: archer sl. J Clin Invest. 2024 Apr 4;134(11):e171002. doi: 10.1172/JCI171002. J Clin Invest. 2024. PMID: 38573824 Free PMC article.
Germline and Somatic Mutations in DNA Methyltransferase 3A (DNMT3A) Predispose to Pulmonary Arterial Hypertension (PAH) in Humans and Mice: Implications for Associated PAH.
Al-Qazazi R, Emon IM, Potus F, Martin AY, Lima PDA, Vlasschaert C, Chen KH, Wu D, Gupta AD, Noordhof C, Jefferson L, McNaughton AJM, Bick AG, Pauciulo MW, Nichols WC, Chung WK, Hassoun PM, Damico RL, Rauh MJ, Archer SL. Al-Qazazi R, et al. Among authors: archer sl. medRxiv [Preprint]. 2023 Dec 31:2023.12.30.23300391. doi: 10.1101/2023.12.30.23300391. medRxiv. 2023. PMID: 38234783 Free PMC article. Preprint.
Publisher Correction: Pulmonary hypertension.
Mocumbi A, Humbert M, Saxena A, Jing ZC, Sliwa K, Thienemann F, Archer SL, Stewart S. Mocumbi A, et al. Among authors: archer sl. Nat Rev Dis Primers. 2024 Jan 17;10(1):5. doi: 10.1038/s41572-024-00493-2. Nat Rev Dis Primers. 2024. PMID: 38233482 No abstract available.
Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension.
Wu D, Jansen-van Vuuren RD, Dasgupta A, Al-Qazazi R, Chen KH, Martin A, Mewburn JD, Alizadeh E, Lima PDA, Jones O, Colpman P, Breault NM, Emon IM, Jedlovčnik L, Zhao YY, Wells M, Sutendra G, Archer SL. Wu D, et al. Among authors: archer sl. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572836. doi: 10.1101/2023.12.21.572836. bioRxiv. 2023. PMID: 38187628 Free PMC article. Preprint.
Pulmonary hypertension.
Mocumbi A, Humbert M, Saxena A, Jing ZC, Sliwa K, Thienemann F, Archer SL, Stewart S. Mocumbi A, et al. Among authors: archer sl. Nat Rev Dis Primers. 2024 Jan 4;10(1):1. doi: 10.1038/s41572-023-00486-7. Nat Rev Dis Primers. 2024. PMID: 38177157 Review.
Multi-omic and multispecies analysis of right ventricular dysfunction.
Mendelson JB, Sternbach JD, Doyle MJ, Mills L, Hartweck LM, Tollison W, Carney JP, Lahti MT, Bianco RW, Kalra R, Kazmirczak F, Hindmarch C, Archer SL, Prins KW, Martin CM. Mendelson JB, et al. Among authors: archer sl. J Heart Lung Transplant. 2024 Feb;43(2):303-313. doi: 10.1016/j.healun.2023.09.020. Epub 2023 Oct 1. J Heart Lung Transplant. 2024. PMID: 37783299
Defining the clinical validity of genes reported to cause pulmonary arterial hypertension.
Welch CL, Aldred MA, Balachandar S, Dooijes D, Eichstaedt CA, Gräf S, Houweling AC, Machado RD, Pandya D, Prapa M, Shaukat M, Southgate L, Tenorio-Castano J; ClinGen PH VCEP; Chung WK; International Consortium for Genetic Studies in Pulmonary Arterial Hypertension (PAH-ICON) at the Pulmonary Vascular Research Institute (PVRI). Welch CL, et al. Genet Med. 2023 Nov;25(11):100925. doi: 10.1016/j.gim.2023.100925. Epub 2023 Jul 5. Genet Med. 2023. PMID: 37422716
A Multi-omic and Multi-Species Analysis of Right Ventricular Failure.
Mendelson JB, Sternbach JD, Doyle MJ, Mills L, Hartweck LM, Tollison W, Carney JP, Lahti MT, Bianco RW, Kalra R, Kazmirczak F, Hindmarch C, Archer SL, Prins KW, Martin CM. Mendelson JB, et al. Among authors: archer sl. bioRxiv [Preprint]. 2023 Feb 8:2023.02.08.527661. doi: 10.1101/2023.02.08.527661. bioRxiv. 2023. Update in: J Heart Lung Transplant. 2024 Feb;43(2):303-313. doi: 10.1016/j.healun.2023.09.020. PMID: 36798212 Free PMC article. Updated. Preprint.
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.
Archer SL, Dasgupta A, Chen KH, Wu D, Baid K, Mamatis JE, Gonzalez V, Read A, Bentley RE, Martin AY, Mewburn JD, Dunham-Snary KJ, Evans GA, Levy G, Jones O, Al-Qazazi R, Ring B, Alizadeh E, Hindmarch CC, Rossi J, Lima PD, Falzarano D, Banerjee A, Colpitts CC. Archer SL, et al. Redox Biol. 2022 Dec;58:102508. doi: 10.1016/j.redox.2022.102508. Epub 2022 Oct 13. Redox Biol. 2022. PMID: 36334378 Free PMC article.
Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH.
Eichstaedt CA, Belge C, Chung WK, Gräf S, Grünig E, Montani D, Quarck R, Tenorio-Castano JA, Soubrier F, Trembath RC, Morrell NW; for PAH-ICON associated with the PVRI. Eichstaedt CA, et al. Eur Respir J. 2023 Feb 23;61(2):2201471. doi: 10.1183/13993003.01471-2022. Print 2023 Feb. Eur Respir J. 2023. PMID: 36302552 Free PMC article.
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.
Al-Qazazi R, Lima PDA, Prisco SZ, Potus F, Dasgupta A, Chen KH, Tian L, Bentley RET, Mewburn J, Martin AY, Wu D, Jones O, Maurice DH, Bonnet S, Provencher S, Prins KW, Archer SL. Al-Qazazi R, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2022 Sep 1;206(5):608-624. doi: 10.1164/rccm.202110-2274OC. Am J Respir Crit Care Med. 2022. PMID: 35699679 Free PMC article.
Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension.
Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M, Montani D, Girerd B, Sitbon O, Boehm M, Novoyatleva T, Schermuly RT, Ghofrani HA, Toshner M, Kiely DG, Howard LS, Swietlik EM, Gräf S, Pietzner M, Morrell NW, Wilkins MR; U.K. National Institute for Health Research BioResource Rare Diseases Consortium, U.K. Pulmonary Arterial Hypertension Cohort Study Consortium, and U.S. Pulmonary Arterial Hypertension Biobank Consortium. Harbaum L, et al. Am J Respir Crit Care Med. 2022 Jun 15;205(12):1449-1460. doi: 10.1164/rccm.202109-2106OC. Am J Respir Crit Care Med. 2022. PMID: 35394406 Free PMC article.
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.
Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S. Romani P, et al. Among authors: archer sl. Nat Cell Biol. 2022 Feb;24(2):168-180. doi: 10.1038/s41556-022-00843-w. Epub 2022 Feb 14. Nat Cell Biol. 2022. PMID: 35165418 Free PMC article.
Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop.
Leopold JA, Kawut SM, Aldred MA, Archer SL, Benza RL, Bristow MR, Brittain EL, Chesler N, DeMan FS, Erzurum SC, Gladwin MT, Hassoun PM, Hemnes AR, Lahm T, Lima JAC, Loscalzo J, Maron BA, Rosa LM, Newman JH, Redline S, Rich S, Rischard F, Sugeng L, Tang WHW, Tedford RJ, Tsai EJ, Ventetuolo CE, Zhou Y, Aggarwal NR, Xiao L. Leopold JA, et al. Among authors: archer sl. Circ Heart Fail. 2021 Jun;14(6):e007975. doi: 10.1161/CIRCHEARTFAILURE.120.007975. Epub 2021 Jun 15. Circ Heart Fail. 2021. PMID: 34422205 Free PMC article. Review.
The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria.
Bentley RET, Hindmarch CCT, Dunham-Snary KJ, Snetsinger B, Mewburn JD, Thébaud A, Lima PDA, Thébaud B, Archer SL. Bentley RET, et al. Among authors: archer sl. Genomics. 2021 Sep;113(5):3128-3140. doi: 10.1016/j.ygeno.2021.07.006. Epub 2021 Jul 8. Genomics. 2021. PMID: 34245829 Free PMC article.
Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.
Omura J, Habbout K, Shimauchi T, Wu WH, Breuils-Bonnet S, Tremblay E, Martineau S, Nadeau V, Gagnon K, Mazoyer F, Perron J, Potus F, Lin JH, Zafar H, Kiely DG, Lawrie A, Archer SL, Paulin R, Provencher S, Boucherat O, Bonnet S. Omura J, et al. Among authors: archer sl. Circulation. 2020 Oct 13;142(15):1464-1484. doi: 10.1161/CIRCULATIONAHA.120.047626. Epub 2020 Jul 23. Circulation. 2020. PMID: 32698630
Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Sou… See abstract for full author list ➔ Rhodes CJ, et al. Among authors: archer sl. Lancet Respir Med. 2019 Mar;7(3):227-238. doi: 10.1016/S2213-2600(18)30409-0. Epub 2018 Dec 5. Lancet Respir Med. 2019. PMID: 30527956 Free PMC article.
Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.
Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM; American Thoracic Society Assembly on Pulmonary Circulation. Lahm T, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST. Am J Respir Crit Care Med. 2018. PMID: 30109950 Free PMC article.
Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.
Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society. Abman SH, et al. Among authors: archer sl. Circulation. 2015 Nov 24;132(21):2037-99. doi: 10.1161/CIR.0000000000000329. Epub 2015 Nov 3. Circulation. 2015. PMID: 26534956
[Relevant issues in the pathology and pathobiology of pulmonary hypertension].
Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW. Tuder RM, et al. Among authors: archer sl. Turk Kardiyol Dern Ars. 2014 Oct;42 Suppl 1:5-16. Turk Kardiyol Dern Ars. 2014. PMID: 25697030 Turkish.
Mitochondrial dynamics in pulmonary arterial hypertension.
Ryan J, Dasgupta A, Huston J, Chen KH, Archer SL. Ryan J, et al. Among authors: archer sl. J Mol Med (Berl). 2015 Mar;93(3):229-42. doi: 10.1007/s00109-015-1263-5. Epub 2015 Feb 13. J Mol Med (Berl). 2015. PMID: 25672499 Free PMC article. Review.
Relevant issues in the pathology and pathobiology of pulmonary hypertension.
Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW. Tuder RM, et al. Among authors: archer sl. J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D4-12. doi: 10.1016/j.jacc.2013.10.025. J Am Coll Cardiol. 2013. PMID: 24355640 Free PMC article. Review.
Rodent models of group 1 pulmonary hypertension.
Ryan JJ, Marsboom G, Archer SL. Ryan JJ, et al. Among authors: archer sl. Handb Exp Pharmacol. 2013;218:105-49. doi: 10.1007/978-3-642-38664-0_5. Handb Exp Pharmacol. 2013. PMID: 24092338 Review.
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL. Piao L, et al. Among authors: archer sl. J Mol Med (Berl). 2013 Mar;91(3):333-46. doi: 10.1007/s00109-012-0982-0. Epub 2012 Dec 18. J Mol Med (Berl). 2013. PMID: 23247844 Free PMC article.
GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.
Piao L, Fang YH, Parikh KS, Ryan JJ, D'Souza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer SL. Piao L, et al. Among authors: archer sl. Circulation. 2012 Dec 11;126(24):2859-69. doi: 10.1161/CIRCULATIONAHA.112.109868. Epub 2012 Nov 2. Circulation. 2012. PMID: 23124027 Free PMC article.
Evolving epidemiology of pulmonary arterial hypertension.
Thenappan T, Ryan JJ, Archer SL. Thenappan T, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2012 Oct 15;186(8):707-9. doi: 10.1164/rccm.201207-1266ED. Am J Respir Crit Care Med. 2012. PMID: 23071187 Free PMC article. No abstract available.
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL. Marsboom G, et al. Among authors: archer sl. Circ Res. 2012 May 25;110(11):1484-97. doi: 10.1161/CIRCRESAHA.111.263848. Epub 2012 Apr 17. Circ Res. 2012. PMID: 22511751 Free PMC article.
Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.
Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer SL. Marsboom G, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2012 Mar 15;185(6):670-9. doi: 10.1164/rccm.201108-1562OC. Epub 2012 Jan 12. Am J Respir Crit Care Med. 2012. PMID: 22246173 Free PMC article.
Epigenetic mechanisms of pulmonary hypertension.
Kim GH, Ryan JJ, Marsboom G, Archer SL. Kim GH, et al. Among authors: archer sl. Pulm Circ. 2011 Jul-Sep;1(3):347-56. doi: 10.4103/2045-8932.87300. Pulm Circ. 2011. PMID: 22140624 Free PMC article.
Perceiving onset clusters in infancy.
Archer SL, Curtin S. Archer SL, et al. Infant Behav Dev. 2011 Dec;34(4):534-40. doi: 10.1016/j.infbeh.2011.07.001. Epub 2011 Aug 3. Infant Behav Dev. 2011. PMID: 21816480
Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.
Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg N, Goldhaber SZ, Jenkins JS, Kline JA, Michaels AD, Thistlethwaite P, Vedantham S, White RJ, Zierler BK; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology. Jaff MR, et al. Among authors: archer sl. Circulation. 2011 Apr 26;123(16):1788-830. doi: 10.1161/CIR.0b013e318214914f. Epub 2011 Mar 21. Circulation. 2011. PMID: 21422387
A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion.
Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. Thenappan T, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2011 Apr 15;183(8):1080-91. doi: 10.1164/rccm.201008-1303OC. Epub 2010 Dec 10. Am J Respir Crit Care Med. 2011. PMID: 21148721 Free PMC article.
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW 2nd, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Erzurum S, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2010 Dec 15;182(12):1554-62. doi: 10.1164/rccm.201006-0869WS. Epub 2010 Sep 10. Am J Respir Crit Care Med. 2010. PMID: 20833821 Free PMC article. Review.
The role of redox changes in oxygen sensing.
Weir EK, Archer SL. Weir EK, et al. Among authors: archer sl. Respir Physiol Neurobiol. 2010 Dec 31;174(3):182-91. doi: 10.1016/j.resp.2010.08.015. Epub 2010 Aug 27. Respir Physiol Neurobiol. 2010. PMID: 20801237 Free PMC article. Review.
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, Dyck JR, Gomberg-Maitland M, Thébaud B, Husain AN, Cipriani N, Rehman J. Archer SL, et al. Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7. Circulation. 2010. PMID: 20529999 Free PMC article.
Diagnosis and management of pulmonary hypertension in systemic sclerosis.
Sweiss NJ, Hushaw L, Thenappan T, Sawaqed R, Machado RF, Patel AR, Gomberg-Maitland M, Husain AN, Archer SL. Sweiss NJ, et al. Among authors: archer sl. Curr Rheumatol Rep. 2010 Feb;12(1):8-18. doi: 10.1007/s11926-009-0078-1. Curr Rheumatol Rep. 2010. PMID: 20425528 Free PMC article. Review.
A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.
Gomberg-Maitland M, Maitland ML, Barst RJ, Sugeng L, Coslet S, Perrino TJ, Bond L, Lacouture ME, Archer SL, Ratain MJ. Gomberg-Maitland M, et al. Among authors: archer sl. Clin Pharmacol Ther. 2010 Mar;87(3):303-10. doi: 10.1038/clpt.2009.217. Epub 2009 Dec 9. Clin Pharmacol Ther. 2010. PMID: 20010555 Free PMC article. Clinical Trial.
The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.
Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL. Piao L, et al. Among authors: archer sl. J Mol Med (Berl). 2010 Jan;88(1):47-60. doi: 10.1007/s00109-009-0524-6. Epub 2009 Dec 1. J Mol Med (Berl). 2010. PMID: 19949938 Free PMC article.
Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.
van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B. van Haaften T, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2009 Dec 1;180(11):1131-42. doi: 10.1164/rccm.200902-0179OC. Epub 2009 Aug 27. Am J Respir Crit Care Med. 2009. PMID: 19713449 Free PMC article.
Cellular and molecular basis of pulmonary arterial hypertension.
Morrell NW, Adnot S, Archer SL, Dupuis J, Lloyd Jones P, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. Morrell NW, et al. Among authors: archer sl. J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S20-S31. doi: 10.1016/j.jacc.2009.04.018. J Am Coll Cardiol. 2009. PMID: 19555855 Free PMC article. Review.
ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association.
McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J; American College of Cardiology Foundation Task Force on Expert Consensus Documents; American Heart Association; American College of Chest Physicians; American Thoracic Society, Inc; Pulmonary Hypertension Association. McLaughlin VV, et al. Among authors: archer sl. J Am Coll Cardiol. 2009 Apr 28;53(17):1573-619. doi: 10.1016/j.jacc.2009.01.004. J Am Coll Cardiol. 2009. PMID: 19389575 Free article. No abstract available.
ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association.
McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J, Harrington RA, Anderson JL, Bates ER, Bridges CR, Eisenberg MJ, Ferrari VA, Grines CL, Hlatky MA, Jacobs AK, Kaul S, Lichtenberg RC, Lindner JR, Moliterno DJ, Mukherjee D, Pohost GM, Rosenson RS, Schofield RS, Shubrooks SJ, Stein JH, Tracy CM, Weitz HH, Wesley DJ; ACCF/AHA. McLaughlin VV, et al. Among authors: archer sl. Circulation. 2009 Apr 28;119(16):2250-94. doi: 10.1161/CIRCULATIONAHA.109.192230. Epub 2009 Mar 30. Circulation. 2009. PMID: 19332472 Review. No abstract available.
Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease.
Rey-Parra GJ, Archer SL, Bland RD, Albertine KH, Carlton DP, Cho SC, Kirby B, Haromy A, Eaton F, Wu X, Thébaud B. Rey-Parra GJ, et al. Among authors: archer sl. Am J Respir Crit Care Med. 2008 Aug 15;178(4):399-406. doi: 10.1164/rccm.200711-1631OC. Epub 2008 May 29. Am J Respir Crit Care Med. 2008. PMID: 18511704 Free PMC article.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED. Nagendran J, et al. Among authors: archer sl. Circulation. 2007 Jul 17;116(3):238-48. doi: 10.1161/CIRCULATIONAHA.106.655266. Epub 2007 Jul 2. Circulation. 2007. PMID: 17606845
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED. Bonnet S, et al. Among authors: archer sl. Cancer Cell. 2007 Jan;11(1):37-51. doi: 10.1016/j.ccr.2006.10.020. Cancer Cell. 2007. PMID: 17222789 Free article.
Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment.
Stewart DJ, Hilton JD, Arnold JM, Gregoire J, Rivard A, Archer SL, Charbonneau F, Cohen E, Curtis M, Buller CE, Mendelsohn FO, Dib N, Page P, Ducas J, Plante S, Sullivan J, Macko J, Rasmussen C, Kessler PD, Rasmussen HS. Stewart DJ, et al. Among authors: archer sl. Gene Ther. 2006 Nov;13(21):1503-11. doi: 10.1038/sj.gt.3302802. Epub 2006 Jun 22. Gene Ther. 2006. PMID: 16791287 Clinical Trial.
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. Bonnet S, et al. Among authors: archer sl. Circulation. 2006 Jun 6;113(22):2630-41. doi: 10.1161/CIRCULATIONAHA.105.609008. Epub 2006 May 30. Circulation. 2006. PMID: 16735674
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