Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 14
1959 17
1960 19
1961 19
1962 23
1963 46
1964 61
1965 70
1966 180
1967 215
1968 214
1969 200
1970 209
1971 186
1972 199
1973 231
1974 297
1975 368
1976 408
1977 603
1978 982
1979 1194
1980 15685
1981 33527
1982 34552
1983 35009
1984 36722
1985 37425
1986 38598
1987 39963
1988 41078
1989 42719
1990 44831
1991 46118
1992 46703
1993 47436
1994 48931
1995 49317
1996 49506
1997 49843
1998 50837
1999 52358
2000 54943
2001 56287
2002 59379
2003 63599
2004 71263
2005 77912
2006 86520
2007 93098
2008 103258
2009 110069
2010 119459
2011 128533
2012 133194
2013 138277
2014 139641
2015 140805
2016 136232
2017 131689
2018 134220
2019 136111
2020 148760
2021 155942
2022 143493
2023 144636
2024 138790
2025 129494
2026 29599
2028 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

3,508,306 results

Results by year

Filters applied: . Clear all
Page 1
Malignancy Risk Following Ophthalmic Herpes Infection Within a Diverse U.S. Cohort.
Mihalache A, Huang RS, Popovic MM, Chan CC. Mihalache A, et al. Ophthalmology. 2026 Apr 9:S0161-6420(26)00238-1. doi: 10.1016/j.ophtha.2026.03.029. Online ahead of print. Ophthalmology. 2026. PMID: 41966483
TOPIC: We evaluated the malignancy risk following herpes zoster ophthalmicus (HZO) and ophthalmic herpes simplex virus (HSV) in a large, diverse U.S. CLINICAL RELEVANCE: There has been a longstanding contention as to whether HZO serves as a clinical marker of cancer …
TOPIC: We evaluated the malignancy risk following herpes zoster ophthalmicus (HZO) and ophthalmic herpes simplex virus (HSV) in a large, div …
Postpartum depressive symptoms and stress are associated with more frequent feeding to soothe in an observational cohort study.
Choe A, Doig AC, Lipsky LM, Nansel TR. Choe A, et al. Appetite. 2026 Apr 9:108560. doi: 10.1016/j.appet.2026.108560. Online ahead of print. Appetite. 2026. PMID: 41966332
Feeding to soothe, referring to parent feeding in response to an infant's distress, is associated with greater subsequent child weight gain, BMI, and emotional eating. Impaired parent mental health and well-being are associated with adverse feeding behaviors in childhood, …
Feeding to soothe, referring to parent feeding in response to an infant's distress, is associated with greater subsequent child weight gain, …
Enantioselective synthesis of chiral cyclic hydroxylamine ethers via NiH-catalyzed cyclization of alkyne-oxime ethers.
Zhou L, Fang J, Tong X, Qi L. Zhou L, et al. Chem Commun (Camb). 2026 Apr 12. doi: 10.1039/d6cc00996d. Online ahead of print. Chem Commun (Camb). 2026. PMID: 41966102
As important scaffolds in organic synthesis, chiral hydroxylamines are highly sought after. Reported herein is the first NiH-catalyzed asymmetric addition to oxime ethers, affording cyclic allylic hydroxylamine ethers with good yields and excellent enantioselectivity. ...
As important scaffolds in organic synthesis, chiral hydroxylamines are highly sought after. Reported herein is the first NiH-catalyze …
Accurate prediction of ecDNA in interphase cancer cells using deep neural networks.
Prasad G, Rajkumar U, Curtis EJ, Wong IT, Yan X, Zhang S, Brückner L, Turner K, Wiese J, Wahl J, Hemmati H, Wu S, Theissen J, Fischer M, Chang HY, Henssen AG, Mischel PS, Bafna V. Prasad G, et al. Commun Biol. 2026 Apr 11. doi: 10.1038/s42003-026-09982-4. Online ahead of print. Commun Biol. 2026. PMID: 41965931
Impact of SARS-CoV-2 vaccination on monoclonal gammopathy of undetermined significance: results from the population-based iStopMM study.
Palmason R, Eythorsson E, Rögnvaldsson S, Thorsteinsdóttir S, Ekberg S, Crowther M, Reed ER, Oskarsson JÞ, Sigurdardottir GA, Aspelund T, Vidarsson B, Onundarson PT, Agnarsson BA, Sigurdardottir M, Thorsteinsdottir I, Sveinsdottir SV, Olafsson I, Thordardottir AR, Jonsson A, Indridason OS, Gislason G, Olafsson A, Sigurdsson JK, Steingrimsdottir H, Einarsson Long T, Hultcrantz M, Durie BGM, Harding S, Landgren O, Palsson R, Love TJ, Kristinsson SY. Palmason R, et al. Blood Cancer J. 2026 Apr 11. doi: 10.1038/s41408-026-01487-x. Online ahead of print. Blood Cancer J. 2026. PMID: 41965847 No abstract available.
Lung microbiome predictors of epigenetic aging and potential associations with smoking and electronic cigarette use.
Khan A, Choi B, Kang S, Weng DY, Ying K, McElroy JP, Kamel S, Reisinger SA, Wewers MD, Shields PG, Song MA. Khan A, et al. Clin Epigenetics. 2026 Apr 11. doi: 10.1186/s13148-026-02126-9. Online ahead of print. Clin Epigenetics. 2026. PMID: 41965787
BACKGROUND: The lungs harbor diverse microbial communities that may influence pulmonary health, potentially through lung aging. While accelerated lung aging can increase susceptibility to pulmonary diseases, no studies have yet linked the lung microbiome to biological agin …
BACKGROUND: The lungs harbor diverse microbial communities that may influence pulmonary health, potentially through lung aging. While …
A prospective single-arm pilot study evaluating [F-18]fluoroestradiol dedicated breast PET in invasive lobular carcinoma after neoadjuvant endocrine therapy.
Switalla KM, Onishi N, Jones EF, Lawhn-Heath C, Ray KM, Hathi DK, Carmona-Bozo JC, Metanat P, Lopes AJ, Falade IO, Quirarte A, Gottipati S, Guo R, Molina-Vega J, Pullakhandam K, Bareng TJ, Watkins M, Chien AJ, Joe BN, Esserman LJ, Hylton N, Mukhtar RA. Switalla KM, et al. Breast Cancer Res. 2026 Apr 11. doi: 10.1186/s13058-026-02277-w. Online ahead of print. Breast Cancer Res. 2026. PMID: 41965734 No abstract available.
Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer.
Heil BN, Baral G, Pfeffer CM, Bahler MB, Gulavani SS, Smith EG, Gartenhaus LE, Darling AK, Clifford SJ, Smith-Kinnaman W, Hansen K, Doud EH, Mall GK, Hata AN, Anderson NL, Olson MR, Allen-Petersen BL. Heil BN, et al. Oncogene. 2026 Apr 11. doi: 10.1038/s41388-026-03772-2. Online ahead of print. Oncogene. 2026. PMID: 41965447
Mechanistic insights into E. coli recovery from growth arrest.
Hassan AH, Nakano Y, Gamper H, Masuda I, Vesela L, Pinkas M, Nagarajan SN, Dworkin J, Blaha G, Hou YM, Demo G. Hassan AH, et al. Nat Commun. 2026 Apr 11. doi: 10.1038/s41467-026-71781-6. Online ahead of print. Nat Commun. 2026. PMID: 41965359
Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM.
Afrin S, Nguyen BA, Singh V, Singh P, Bassett P, Pekala M, Evers B, Lopez C, Ahmed Y, Li L, Kallem RR, Lemoff A, Argyropoulos C, Kluve-Beckerman B, Saelices L. Afrin S, et al. Nat Commun. 2026 Apr 11. doi: 10.1038/s41467-026-71223-3. Online ahead of print. Nat Commun. 2026. PMID: 41965342
Impact of wet- and dry-lab workflows on genome assembly, typing and enterotoxin gene detection in whole-genome sequencing of foodborne Staphylococcus aureus.
Vingadassalon N, Hennekinne JA, Nia Y, Maurischat S, Borowiak M, Byrne B, Dygico LK, Ciupescu L, Guedes H, Almeida G, Rola J, Bomba A, Kibilds J, Kubicova Z, Mackiw E, Kowalska J, Romanó A, Rojo LV, Romano A, Zuccon F, Van Nieuwenhuysen T, Bogaerts B, Vanneste K, Cavaiuolo M. Vingadassalon N, et al. Int J Food Microbiol. 2026 Apr 3;455:111761. doi: 10.1016/j.ijfoodmicro.2026.111761. Online ahead of print. Int J Food Microbiol. 2026. PMID: 41965222
An Inter-laboratory Comparison Test (ILCT) on the application of whole genome sequencing (WGS) for typing and characterisation of foodborne Staphylococcus aureus isolates was organised by the European Reference Laboratory for Coagulase-Positive Staphylococci (EURL for CPS) from 2 …
An Inter-laboratory Comparison Test (ILCT) on the application of whole genome sequencing (WGS) for typing and characterisation of foodborne …
Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health.
Ajufo E, Kany S, Rämö JT, Churchill TW, Guseh JS, Aragam KG, Ellinor PT, Khurshid S. Ajufo E, et al. JACC Adv. 2026 Apr 9;5(5):102718. doi: 10.1016/j.jacadv.2026.102718. Online ahead of print. JACC Adv. 2026. PMID: 41965143
Avoiding excess sedentary behavior should be a key public health target....
Avoiding excess sedentary behavior should be a key public health target....
Composition-tunable hyaluronic acid/zwitterionic hybrid fibrous biointerfaces for programmable CD44-mediated cell adhesion and flow-triggered release.
Chyuan IT, Chiu MH, Lai CY, Tsao CW, Cheng YC, Lee YH, Hu WW. Chyuan IT, et al. Colloids Surf B Biointerfaces. 2026 Apr 6;265:115676. doi: 10.1016/j.colsurfb.2026.115676. Online ahead of print. Colloids Surf B Biointerfaces. 2026. PMID: 41965137
The mats were integrated into a custom flow channel, where mixed A549 (CD44+) and NIH-3T3 (CD44-) suspensions underwent a two-step protocol: low-flow washing of non-adherent cells followed by flow-triggered detachment of adherent CD44+ cells, enabling recovery without enzy …
The mats were integrated into a custom flow channel, where mixed A549 (CD44+) and NIH-3T3 (CD44-) suspensions underwent a two-step pr …
Trans-scleral cryotherapy in the management of retinal hemangioblastomas.
Broadhead GK, Wiley HE, Agrón E, Dao D, Chew EY, Coleman H, Thavikulwat AT. Broadhead GK, et al. Graefes Arch Clin Exp Ophthalmol. 2026 Apr 11. doi: 10.1007/s00417-026-07208-1. Online ahead of print. Graefes Arch Clin Exp Ophthalmol. 2026. PMID: 41964887 No abstract available.
Persistent HIV Transmission Misconceptions Among People Who Inject Drugs in Massachusetts, USA.
Shaw LC, Jimenez YS, Sproesser DM, Hayes E, Baumgartner K, Krakower DS, Bordeu M, Mimiaga MJ, Bositis CM, Bazzi AR, Biello KB. Shaw LC, et al. AIDS Behav. 2026 Apr 11. doi: 10.1007/s10461-026-05117-2. Online ahead of print. AIDS Behav. 2026. PMID: 41964811
Misconceptions present since the early era of the HIV epidemic remain prevalent among PWID in this region, despite access to robust harm reduction and HIV prevention services. Findings highlight the importance of dispelling long-standing myths, strengthening education abou …
Misconceptions present since the early era of the HIV epidemic remain prevalent among PWID in this region, despite access to robust harm red …
PrEP Use Willingness and Perceptions Among Young Female Sex Workers in Kisumu, Kenya: Implications for HIV Prevention.
Omollo D, Murnane P, Ayallo J, Onyango J, Weiser SD. Omollo D, et al. AIDS Behav. 2026 Apr 11. doi: 10.1007/s10461-026-05122-5. Online ahead of print. AIDS Behav. 2026. PMID: 41964810
While most FSW in Kisumu City were aware of PrEP and perceived it positively, uptake was hindered by stigma, discomfort with health services, and lifestyle factors like mobility. To close the gap between awareness and actual use of PrEP, there is need for flexible a …
While most FSW in Kisumu City were aware of PrEP and perceived it positively, uptake was hindered by stigma, discomfort with health …
Perceptions About the Relationship Between HIV, Antiretroviral Therapy (ART), and Fecundity in Sub-Saharan Africa: Findings from a Systematic Scoping Review.
Sedlander E, El Ayadi AM, Wairimu N, Ackernecht J, Velloza J, Cedars MI, Ngure K, Gandhi M. Sedlander E, et al. AIDS Behav. 2026 Apr 11. doi: 10.1007/s10461-026-05111-8. Online ahead of print. AIDS Behav. 2026. PMID: 41964809 Review.
Of 1,981 sources identified, only 12 met the inclusion criteria uncovering the following themes: (1) Beliefs that HIV and PrEP cause infertility exist but have not been widely documented; (2) Perceptions that ART improves health before pregnancy motivates women to adhere a …
Of 1,981 sources identified, only 12 met the inclusion criteria uncovering the following themes: (1) Beliefs that HIV and PrEP cause inferti …
Action classification for endoscopic pituitary adenoma resection: a consensus-based study.
Starup-Hansen J, Khan DZ, Das A, Almeida JP, Bano S, Borg A, Cleary K, Dorward N, Fernandez-Miranda JC, Torres-Rodríguez E, Stoyanov D, Yilmaz R, Weir P, Donoho DA, Marcus HJ. Starup-Hansen J, et al. Int J Comput Assist Radiol Surg. 2026 Apr 11. doi: 10.1007/s11548-026-03614-2. Online ahead of print. Int J Comput Assist Radiol Surg. 2026. PMID: 41964780
Post-Operative Safety Outcomes and 5-Year Healthcare Utilisation After Bariatric Surgery vs. Other Elective Types of Surgical Treatments - A Retrospective Observational Cohort Study.
Chamseddine G, David McIntyre R, Panagiotopoulos S, Rudisill AC, Casella J, Castagneto-Gissey L, Chang A, Galata G, Haji A, Haq A, Genser L, Mingrone G, Patel A, Salerno A, Tassinari D, Rubino F. Chamseddine G, et al. Obes Surg. 2026 Apr 11. doi: 10.1007/s11695-026-08584-7. Online ahead of print. Obes Surg. 2026. PMID: 41964779 No abstract available.
The Effects of Lumbar Delayed Onset Muscle Soreness on Clinical, Biomechanical and Neuromuscular Outcomes: A Systematic Review and Meta-Analysis.
Ducas J, Véret C, Gauthier-Wong É, Descarreaux M, Abboud J. Ducas J, et al. Eur J Pain. 2026 Apr;30(4):e70264. doi: 10.1002/ejp.70264. Eur J Pain. 2026. PMID: 41964504 Review.
Independent study selection, data extraction and risk-of-bias assessment (NIH Quality Assessment Tool) were performed. Random-effects meta-analysis calculated standardized mean differences (SMDs). ...
Independent study selection, data extraction and risk-of-bias assessment (NIH Quality Assessment Tool) were performed. Random-effects …
Investigation of the potential of bisphenol A substitutes to induce allergic contact sensitization using OECD defined approaches.
Johnson VJ, Gulledge TV, Luster MI, Burleson GR, Burleson FG, Germolec D. Johnson VJ, et al. ALTEX. 2026 Apr 9. doi: 10.14573/altex.2512011. Online ahead of print. ALTEX. 2026. PMID: 41964411
The public is also at risk of dermal exposure due to environmental contamination. Due to public health concerns regarding the potential for endocrine disrupting effects, efforts have been applied to replace bisphenol A with safer alternatives. ...Bisphenol A (BPA) is a wid …
The public is also at risk of dermal exposure due to environmental contamination. Due to public health concerns regarding the potenti …
The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome.
Abdullah LB, Zhang F, Petersen M, Hall J, Handen BL, Mapstone M, Christian B, Head E, Harley S, Andrews H, Lee JH, Tudorascu D, Hom C, Zaman S, Brickman AM, Rosas D, Cohen A, Harp JP, Schmitt F, Ptomey L, Burns JM, Lott IT, Lai F, Laymon C, Cruchaga C, O'Bryant S, Ances BM. Abdullah LB, et al. Alzheimers Dement. 2026 Apr;22(4):e71338. doi: 10.1002/alz.71338. Alzheimers Dement. 2026. PMID: 41964394 Free PMC article.
Executive function challenges persist into young adulthood and predict mental health outcomes in autism.
Kenworthy L, Baczewski L, Gerber AH, Pugliese CE, Armour AC, Csumitta KD, Reimann GE, Candy C, Wallace GL, Fritz MS. Kenworthy L, et al. J Child Psychol Psychiatry. 2026 Apr 11. doi: 10.1111/jcpp.70149. Online ahead of print. J Child Psychol Psychiatry. 2026. PMID: 41964372
BACKGROUND: Executive functioning (EF) challenges are common among autistic youth and persist throughout childhood and adolescence; they have been linked to important outcomes, including poorer mental health, adaptive skills, and overall quality of life. Despite the signif …
BACKGROUND: Executive functioning (EF) challenges are common among autistic youth and persist throughout childhood and adolescence; they hav …
Adult tobacco product use patterns across the urban-rural continuum: The longitudinal Population Assessment of Tobacco and Health (PATH) study, 2016-2023.
Zhang J, Rose SW, Hahn EJ, Roberts ME, Fennell BS, Ozga JE, Himelhoch S, Feizy S, Christian WJ, Wiggins AT, Abadi M, Mattingly DT, Rayens MK. Zhang J, et al. J Rural Health. 2026 Mar;42(2):e70140. doi: 10.1111/jrh.70140. J Rural Health. 2026. PMID: 41964313
METHODS: Data from Waves 4-7 (2016-2023) of the Population Assessment of Tobacco and Health (PATH) study (N = 18,590 adults) were analyzed using survey-weighted logistic regression to evaluate location and time differences in likelihoods of current, daily, and established …
METHODS: Data from Waves 4-7 (2016-2023) of the Population Assessment of Tobacco and Health (PATH) study (N = 18,590 adults) were ana …
Effect of gonadectomy and hormone replacement on habenula-induced dopamine inhibition in female and male rats.
Waldron VJ, Suttawireesan M, Fatimah S, Merchenthaler IJ, Brown PL. Waldron VJ, et al. J Neuroendocrinol. 2026 Apr;38(4):e70183. doi: 10.1111/jne.70183. J Neuroendocrinol. 2026. PMID: 41964284 Free PMC article.
Sex differences have been noted in the prevalence and severity of several neurological and mental health disorders. Midbrain dopaminergic activity is implicated in the etiology of many of these disorders and therefore may also contribute to some commonly seen sex differenc …
Sex differences have been noted in the prevalence and severity of several neurological and mental health disorders. Midbrain dopamine …
High-fat diet attenuates estradiol's efficacy on cognitive function and hippocampal synaptic plasticity in middle-aged ovariectomized mice.
Felintro V, Desmoulins LD, Dugas CM, Dos Santos IP, Offor SN, Taylor HJ, Zha J, Zsombok A, Schrader LA. Felintro V, et al. Physiol Rep. 2026 Apr;14(7):e70867. doi: 10.14814/phy2.70867. Physiol Rep. 2026. PMID: 41964268 Free PMC article.
These findings suggest that high-fat diet may interfere with the neuroprotective mechanisms of estrogen within the hippocampus and highlight the importance of metabolic health status in determining the efficacy of hormone therapy during aging....
These findings suggest that high-fat diet may interfere with the neuroprotective mechanisms of estrogen within the hippocampus and highlight …
Simultaneous Assessment of Intracranial Artery and Paravascular CSF Pulsation Using 3D Whole-Brain Diffusion-Prepared Cine bSSFP (DECAF) MRI.
Ni C, Hou X, HashemizadehKolowri S, Kim SE, Wen Q, Frost NA, McNally JS, Yuan C, Ma X. Ni C, et al. Magn Reson Med. 2026 Apr 10. doi: 10.1002/mrm.70381. Online ahead of print. Magn Reson Med. 2026. PMID: 41964118
PURPOSE: To propose a noninvasive and quantitative MRI approach to simultaneously assessing intracranial artery pulsation and paravascular cerebrospinal fluid (CSF) pulsation in the human brain. METHODS: We developed a 3D whole-brain Diffusion-prepared Cine bSSFP (DECAF) M …
PURPOSE: To propose a noninvasive and quantitative MRI approach to simultaneously assessing intracranial artery pulsation and paravascular c …
Loss of salivary agglutinin induces changes in the salivary microbiome and accelerates development of oral cancer.
de Medeiros MC, Fontaine S, Danella E, Hillman E, Schmidt TM, Furgal A, Wellik DM, Inohara N, Núñez G, Li G, Chen GY, D'Silva NJ. de Medeiros MC, et al. Microbiome. 2026 Apr 10. doi: 10.1186/s40168-026-02337-5. Online ahead of print. Microbiome. 2026. PMID: 41964098 Free article.
In this study, OSCC development was investigated in a murine carcinogen model that simulates human OSCC. Microbiota were standardized between Dmbt1 knockout (Dmbt1(-/-)) and wild-type (Dmbt1(+/+)) mice via interbreeding and co-housing. ...
In this study, OSCC development was investigated in a murine carcinogen model that simulates human OSCC. Microbiota were standardized …
Organizational readiness and program sustainability within juvenile justice and community mental health: the mediating role of cross-system collaboration.
O'Reilly LM, Dir A, Schwartz K, Kim Y, Borowiecki M, Taylor B, Adams ZW, Zapolski T, Hulvershorn L, Aalsma MC. O'Reilly LM, et al. Implement Sci Commun. 2026 Apr 10. doi: 10.1186/s43058-026-00919-w. Online ahead of print. Implement Sci Commun. 2026. PMID: 41964039 Free article.
BACKGROUND: Evidence-based system-level intervention is needed to address the problem of poor connection to behavioral health (BH) services among justice-involved youth. System preparedness to implement evidence-based practices (EBP) or interventions, i.e. ...METHOD …
BACKGROUND: Evidence-based system-level intervention is needed to address the problem of poor connection to behavioral health (BH) …
Sex influences on tumor innervation.
Barclay SM, Barr J, Isaiah O, Bajpai M, Bullard H, Neufeld E, Welbon CC, Ghosh P, Brockhaus DS, Spanos WC, Vermeer PD. Barclay SM, et al. Biol Sex Differ. 2026 Apr 10. doi: 10.1186/s13293-026-00887-9. Online ahead of print. Biol Sex Differ. 2026. PMID: 41964002 Free article.
Continuum of Core 1 biomarkers in preclinical Alzheimer's disease.
Digma LA, Young CB, Winer JR, Cody KA, Younes K, Sheng J, Insel PS, Rissman RA, Sperling R, Mormino EC. Digma LA, et al. Alzheimers Res Ther. 2026 Apr 10. doi: 10.1186/s13195-026-02044-1. Online ahead of print. Alzheimers Res Ther. 2026. PMID: 41963989 Free article. No abstract available.
Enhancing capacity in faith-based organizations to implement and sustain multilevel innovations to improve physical activity: study protocol for the faith in action type II hybrid implementation-effectiveness trial.
Arredondo EM, Schneider J, Chuang E, Rabin B, Lin CD, Brownson RC, Hooker SP, Torres-Ruiz MS, Telles V, Martinez SanRoman I, Chagolla D, Garcia-Villegas J, Gomez M, Formagini T, Lafuente O, Clark SD, Galvan MO, Ayala GX. Arredondo EM, et al. BMC Public Health. 2026 Apr 10. doi: 10.1186/s12889-026-27147-0. Online ahead of print. BMC Public Health. 2026. PMID: 41963892 Free article. No abstract available.
Social anxiety is associated with greater autonomic and visuocortical generalization of conditioned aversive responses to faces.
Pouliot JJ, Ward RT, Gilbert F, Chiasson P, Traiser C, Keil A. Pouliot JJ, et al. Cogn Affect Behav Neurosci. 2026 Apr 10. doi: 10.3758/s13415-026-01437-x. Online ahead of print. Cogn Affect Behav Neurosci. 2026. PMID: 41963764
However, this process is exaggerated in persons with anxiety disorders, leading to overgeneralization of learned threat associations, hyperreactive fight-or-flight responses, and persistent avoidance. Patients with social anxiety disorder (SAD) exhibit impaired conditioned …
However, this process is exaggerated in persons with anxiety disorders, leading to overgeneralization of learned threat associations, hyperr …
Comparing Neighborhood Indices of Socioeconomic Status, Segregation, and Healthcare Access for Predicting Late-Stage Breast Cancer.
Dunn MR, Mukhopadhyay S, Gomez SL, McCullough LE, Hyslop T, Emerson MA, Troester MA. Dunn MR, et al. J Urban Health. 2026 Apr 10. doi: 10.1007/s11524-026-01072-4. Online ahead of print. J Urban Health. 2026. PMID: 41963758
Composite indices of neighborhood-level social environment are frequently used in cancer research, but relationships among these indices have been seldom studied, especially in race-stratified analyses. We considered four census tract-level social indices: Neighborh …
Composite indices of neighborhood-level social environment are frequently used in cancer research, but relationships among these indi …
Vaccine elicitation of HIV broadly neutralizing antibodies from genome-edited B cells in non-human primates and derived lymphoid organoids.
Tenuta M, Bravo M, Olson A, Saney CL, Weinfurter J, Ben-Akiva E, Bhange D, Cottrell CA, Vosler L, Weisgrau K, Burton DR, Irvine DJ, Schief WR, Rakasz E, Joyner CJ, Voss JE. Tenuta M, et al. Gene Ther. 2026 Apr 10. doi: 10.1038/s41434-026-00610-8. Online ahead of print. Gene Ther. 2026. PMID: 41963633
HIV broadly neutralizing antibodies (bnAbs) are promising reagents for prevention and therapy of disease; however, their elicitation is constrained by genetic limitations of the human B cell antigen-receptor (BCR) repertoire. Precision genome-editing offers a potential sol …
HIV broadly neutralizing antibodies (bnAbs) are promising reagents for prevention and therapy of disease; however, their elicitation is cons …
SenSet defines cell-type specific senescence signatures in the aged human lung.
Hasanaj E, Beaulieu D, Wang C, Hu Q, Rosas L, Bueno M, Sembrat JC, Pineda RH, Melo-Narvaez MC, Cardenes N, Yanwu Z, Yingze Z, Lafyatis R, Morris A, Mora A, Rojas M, Li D, Rahman I, Pryhuber GS, Lehmann M, Alder J, Gurkar A, Finkel T, Ma Q, Lugo-Martinez J, Póczos B, Bar-Joseph Z, Eickelberg O, Königshoff M. Hasanaj E, et al. EMBO J. 2026 Apr 10. doi: 10.1038/s44318-026-00762-8. Online ahead of print. EMBO J. 2026. PMID: 41963555 Free article.
The relatively low abundance of senescent cells in healthy aged tissues poses a major challenge to the longitudinal study of senescence in specific organs, including the human lung. To overcome this limitation, we developed a positive-unlabeled learning framework to genera …
The relatively low abundance of senescent cells in healthy aged tissues poses a major challenge to the longitudinal study of senescence in s …
Estimating the generation time for SARS-CoV-2 transmission using United States household data, December 2021-May 2023.
Chan LYH, Morris SE, Stockwell MS, Bowman NM, Asturias E, Rao S, Lutrick K, Ellingson KD, Nguyen HQ, Maldonado Y, McLaren SH, Sano E, Biddle JE, Smith-Jeffcoat SE, Biggerstaff M, Rolfes MA, Talbot HK, Grijalva CG, Borchering RK, Mellis AM; RVTN-Sentinel Study Group. Chan LYH, et al. Sci Rep. 2026 Apr 11. doi: 10.1038/s41598-026-46596-6. Online ahead of print. Sci Rep. 2026. PMID: 41963433 Free article. No abstract available.
Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2.
Rea-Moreno M, Tian L, Tavakol TN, Yang MC, Pek NM, Gulati S, Bugacov H, Cusmai C, Dawodu G, Klotz RV, Garcia IM, Chen HY, Zhang CC, Pan H, Li X, Wolf AS, Huang H, Yu DH, Ichida JK, Sahoo S, Cannon PM, Que J, Scheinin SA, Laskey D, Vicencio AG, Januska MN, Guenthart BA, Johnson J, Yu M, Gu M, Tiozzo C, Chen YW. Rea-Moreno M, et al. Nat Commun. 2026 Apr 10. doi: 10.1038/s41467-026-71680-w. Online ahead of print. Nat Commun. 2026. PMID: 41963354 Free article.
Traditionally, TMPRSS2 has been described as a cell surface protein, but our study reveals that in human lung epithelial cells, TMPRSS2 is largely absent from the plasma membrane and instead resides intracellularly. ...
Traditionally, TMPRSS2 has been described as a cell surface protein, but our study reveals that in human lung epithelial cells, TMPRS …
Pervasive non-triplet alternative splicing drives functional isoform diversity.
Athavudeen S, Issac N, Norris A. Athavudeen S, et al. Nat Commun. 2026 Apr 10. doi: 10.1038/s41467-026-71615-5. Online ahead of print. Nat Commun. 2026. PMID: 41963350 Free article.
Genetic and molecular analyses reveal cases of developmental regulation, splicing factor autoregulation, cell-specific splicing, and physiologically important isoform-specific function. Analysis of human transcriptomes reveals broadly similar patterns and distributions of …
Genetic and molecular analyses reveal cases of developmental regulation, splicing factor autoregulation, cell-specific splicing, and physiol …
Assembling unmapped reads reveals hidden variation in South Asian genomes.
Das A, Biddanda A, McCoy RC, Schatz MC. Das A, et al. Nat Commun. 2026 Apr 10. doi: 10.1038/s41467-026-71755-8. Online ahead of print. Nat Commun. 2026. PMID: 41963335 Free article.
To explore this hidden variation, here we examine unmapped and poorly mapped reads from the genomes of 640 human individuals from South Asian populations in the 1000 Genomes Project and the Simons Genome Diversity Project. ...Our results highlight the limitations of even t …
To explore this hidden variation, here we examine unmapped and poorly mapped reads from the genomes of 640 human individuals from Sou …
Clinical validation of a high-performance somatic exome sequencing assay: from target-enrichment strategy to variant calling.
Tsuji J, Rickles-Young M, Abreu J, Friedman A, Petersen C, Bryan J, Scheffler K, O'Connell T, Heyns T, Malolepsza E, Fleharty M, Larkin K, Livak KJ, Li S, Reardon DA, Wu CJ, Ott PA, Dao F, Rehm H, Jan M, Stewart C, Getz G, Jain V, Catreux S, Cibulskis C, Lennon N. Tsuji J, et al. NPJ Genom Med. 2026 Apr 10. doi: 10.1038/s41525-026-00569-w. Online ahead of print. NPJ Genom Med. 2026. PMID: 41963325 Free article.
Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease.
Smith AM, Lorkiewicz SA, Arslan B, Montoliu-Gaya L, Ashton NJ, Wilson EN, Alcolea D, Rodríguez-Baz Í, Fortea J, Young CB, Winer JR, Shahid-Besanti M, Vossler H, Plastini MJ, Pan T, Vera-Campuzano E, Sala I, Mendiola JH, Ramirez V, Kerchner GA, Andreasson KI, Henderson VW, Montine TJ, Tian L, Mormino EC, Zetterberg H, Poston KL, Abdelnour C. Smith AM, et al. NPJ Parkinsons Dis. 2026 Apr 10. doi: 10.1038/s41531-026-01341-8. Online ahead of print. NPJ Parkinsons Dis. 2026. PMID: 41963316 Free article.
Berry-derived gold nanoparticles induce integrated ROS-mediated apoptosis, immune modulation, and transcriptomic remodeling in 4T1 triple-negative cancer cells.
Fagbohun OF, Oladipo AO, Gao C, Olawoye B, Berry RS, Captain JC, Iragena O, McDougle X, Harris RJ, Rollins A, Joseph JS, Fadare OA, Kincaid R. Fagbohun OF, et al. Cell Death Discov. 2026 Apr 10. doi: 10.1038/s41420-026-03023-z. Online ahead of print. Cell Death Discov. 2026. PMID: 41963310 Free article.
Multiple sequence alignment with WT mouse and human protein sequences demonstrated that mutations present in 4T1 cells are within highly conserved motifs of key tumor suppressors, emphasizing their relevance to human breast cancer biology. ...
Multiple sequence alignment with WT mouse and human protein sequences demonstrated that mutations present in 4T1 cells are within hig …
An update on cystic fibrosis Hepato-biliary involvement.
Freeman AJ, Bodewes FAJA. Freeman AJ, et al. J Cyst Fibros. 2026 Apr 9:S1569-1993(26)00090-1. doi: 10.1016/j.jcf.2026.03.022. Online ahead of print. J Cyst Fibros. 2026. PMID: 41963204 Review.
Longitudinal studies such as PUSH, combined with national patient registry data, has greatly improved our understanding of the natural history of CFHBI. ...
Longitudinal studies such as PUSH, combined with national patient registry data, has greatly improved our understanding of the natura …
Structural Basis for the Mechanism and Stability of the EEPD1 5' Endonuclease.
Hromas RA, Jaiswal AS, Misra A, Yuan Y, Zhou D, Beckman JI, Arya S, Chidambaram A, Taylor AB, Griffith W, Jaiswal A, Williamson EA, Gupta YK. Hromas RA, et al. J Biol Chem. 2026 Apr 8:111432. doi: 10.1016/j.jbc.2026.111432. Online ahead of print. J Biol Chem. 2026. PMID: 41962867 Free article.
Natural history of limb girdle muscular dystrophy R1 (LGMDR1): a GRASP consortium study.
Hunn SM, Findlay AR, Alfano LN, Jones A, Butler A, Lowes LP, Iammarino MA, Reash NF, Pietruszewski L, Sasidharan S, Currence M, Statland JM, Strahler T, Will R, Wicklund M, Dixon S, Augsburger R, Mozaffar T, Laubscher KM, Mockler SRH, Mathews KD, Stinson N, Leung DG, Stark MM, Horton RA, Kang PB, James MK, Clause A, Weihl CC, Johnson NE; GRASP-LGMD Consortium. Hunn SM, et al. Neuromuscul Disord. 2026 Apr 1;63:106416. doi: 10.1016/j.nmd.2026.106416. Online ahead of print. Neuromuscul Disord. 2026. PMID: 41962316
Associations of Fine Particulate Matter and Its Specific Components With Recurrent Stroke and Secondary Morbidity and Mortality.
Zhu Z, Zhu Q, Yu P, Wang Y, Liu T, Jiang Y. Zhu Z, et al. Neurology. 2026 May 12;106(9):e214879. doi: 10.1212/WNL.0000000000214879. Epub 2026 Apr 10. Neurology. 2026. PMID: 41962117
METHODS: We analyzed data from first-ever stroke patients in the Third China National Stroke Registry, and follow-up was conducted through March 2023. Ambient PM(2.5) and its components were assessed using one-year average concentrations before the end point or the latest …
METHODS: We analyzed data from first-ever stroke patients in the Third China National Stroke Registry, and follow-up was conducted th …
Feasibility of Automated Laboratory Data Ascertainment and Transfer From Hospitals Into Medidata Rave Across Pediatric National Cancer Institute-Supported Cooperative Groups.
Miller TP, Aplenc R, Minard C, Lensing S, Wang Y, Velamuru P, Foster JH, Silverman M, Sung C, Wong K, Beeles T, Fangusaro J, Weigel BJ, Onar-Thomas A, Fox E. Miller TP, et al. JCO Clin Cancer Inform. 2026 Apr;10(2):e2500359. doi: 10.1200/CCI-25-00359. Epub 2026 Apr 10. JCO Clin Cancer Inform. 2026. PMID: 41962070
The Children's Oncology Group Pediatric Early Phase Clinical Trials Network (PEP-CTN) and Pediatric Brain Tumor Consortium (PBTC) conducted a joint pilot that aimed to assess feasibility of automated transfer of laboratory data from electronic health records to the Medidat …
The Children's Oncology Group Pediatric Early Phase Clinical Trials Network (PEP-CTN) and Pediatric Brain Tumor Consortium (PBTC) conducted …
White House Proposes Cuts to NIH Funding for FY27.
[No authors listed] [No authors listed] Cancer Discov. 2026 Apr 10:OF1. doi: 10.1158/2159-8290.CD-NW2026-0038. Online ahead of print. Cancer Discov. 2026. PMID: 41961996
Under the Trump Administration's proposed budget for fiscal year 2027, and if enacted, the NIH would receive $41.2 billion, down from $47.22 in fiscal year 2026, and NCI would receive $7.353 billion, an increase of $8.9 million, or 0.1%. ...
Under the Trump Administration's proposed budget for fiscal year 2027, and if enacted, the NIH would receive $41.2 billion, down from …
Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.
Olson AW, Li J, Li XY, King L, Jiang L, Banerjee K, McCoy AJ, Gondal MN, Chinnaiyan AM, El-Ashry D, Keller ET, Putnam AJ, Weiss SJ. Olson AW, et al. Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2520717123. doi: 10.1073/pnas.2520717123. Epub 2026 Apr 10. Proc Natl Acad Sci U S A. 2026. PMID: 41961858
Here, we use cancer spheroid-3-dimensional matrix models, single-cell RNA sequencing, and human tissue explants to identify the mechanisms controlling mesenchymal versus amoeboid invasion. ...Nevertheless, when cancer cells confront explants of live human breast tis …
Here, we use cancer spheroid-3-dimensional matrix models, single-cell RNA sequencing, and human tissue explants to identify the mecha …
Conformational equilibria in the activation of cystine-knot hormone receptors.
Gong Z, Hendrickson WA. Gong Z, et al. Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2536028123. doi: 10.1073/pnas.2536028123. Epub 2026 Apr 10. Proc Natl Acad Sci U S A. 2026. PMID: 41961847
Human glycoprotein hormones such as thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) belong to a broader family of cystine-knot hormones (CKHs), all of which act through leucine-rich-repeat (LRR)-containing G protein-coupled receptors (LGRs) with wh …
Human glycoprotein hormones such as thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) belong to a broader fami …
The Latino health experience: Past and future.
Goldman N, Pebley AR. Goldman N, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2530795123. doi: 10.1073/pnas.2530795123. Epub 2026 Apr 10. Proc Natl Acad Sci U S A. 2026. PMID: 41961823
Our finding of a relatively weak social gradient in several health outcomes for Latinos suggests that being of higher socioeconomic status confers a smaller health benefit compared to being of lower status relative to the White population. We underscore the i …
Our finding of a relatively weak social gradient in several health outcomes for Latinos suggests that being of higher socioeco …
Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut-on-a-Chip.
Min S, Than N, Shin YC, Ertugral EG, Kothapalli CR, Awoniyi O, Kim HJ. Min S, et al. Adv Sci (Weinh). 2026 Apr 10:e16040. doi: 10.1002/advs.202516040. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 41961487
Biomechanical cues such as fluid shear stress and mechanical strain regulate intestinal physiology, yet their roles in shaping fibroblast fate during early fibrotic remodeling remain poorly defined. Here, we use a microengineered human gut-on-a-chip model that enables inde …
Biomechanical cues such as fluid shear stress and mechanical strain regulate intestinal physiology, yet their roles in shaping fibroblast fa …
ERK-Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells.
Zhao X, Erhardt S, Tang L, Chen X, Farmer SM, Cheng Z, Chen W, Lu EZ, Sung K, Tsai CR, Zheng M, Zhang S, Liu Y, Wang J, Li M, Martin JF, Wang J. Zhao X, et al. Adv Sci (Weinh). 2026 Apr 10:e11484. doi: 10.1002/advs.202511484. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 41961483
This mechanism is conserved across mouse and human cells and is active in Apert syndrome-associated FGF gain-of-function models, revealing a previously unrecognized FGF-YAP axis in stem cell regulation....
This mechanism is conserved across mouse and human cells and is active in Apert syndrome-associated FGF gain-of-function models, reve …
The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.
Wells JL, Rabinowitz JA, Maher BS, Gentry AE, Burch JB, Prom-Wormley EC. Wells JL, et al. Behav Genet. 2026 Apr 10. doi: 10.1007/s10519-026-10263-3. Online ahead of print. Behav Genet. 2026. PMID: 41961466
The current study evaluates the use of MDD and AUD PGS individually and together to improve the prediction of MDD, AUD, and comorbid MDD-AUD using a sample of European, African, or Admixed American Ancestry participants from the National Longitudinal Study of Adolescent to …
The current study evaluates the use of MDD and AUD PGS individually and together to improve the prediction of MDD, AUD, and comorbid MDD-AUD …
Identification of mitochondria-related genes in calcific aortic valve disease by integrated analysis of single-cell and bulk transcriptomic atlases.
Mai Z, Du H, Chen Y, Lu Y, Liu B, Sun D. Mai Z, et al. J Physiol Biochem. 2026 Apr 10;82(1):36. doi: 10.1007/s13105-026-01176-0. J Physiol Biochem. 2026. PMID: 41961374 Free PMC article.
To elucidate these mechanisms, we integrated single-cell transcriptomic datasets comparing normal and calcified human aortic valves to identify 200 differentially expressed mitochondria-related genes (DE-MRGs), each exhibiting distinct expression patterns across diverse ce …
To elucidate these mechanisms, we integrated single-cell transcriptomic datasets comparing normal and calcified human aortic valves t …
Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis.
Coffey EL, Gomez A, Tate NM, Baker LA, Lulich JP, Furrow E. Coffey EL, et al. Metabolomics. 2026 Apr 10;22(2):50. doi: 10.1007/s11306-026-02429-1. Metabolomics. 2026. PMID: 41961373 Free PMC article.
Reduced N-delta-acetylornithine in stone formers is also reported in human stone formers and might reflect dietary acid load. Acetylcarnitine and carnitine enrichment in the urine of stone formers also warrants further exploration....
Reduced N-delta-acetylornithine in stone formers is also reported in human stone formers and might reflect dietary acid load. Acetylc …
A rapid review of genetic association studies of parent-of-origin effects and fetal growth.
Kang EJW, Dewan AT. Kang EJW, et al. Mol Cell Pediatr. 2026 Apr 10;13(1):13. doi: 10.1186/s40348-026-00224-5. Mol Cell Pediatr. 2026. PMID: 41961219 Free PMC article. Review.
BACKGROUND: Genetic factors contribute, in part, to fetal growth restriction (FGR), a developmental condition of disrupted fetal development associated with serious health consequences. Among these factors, variants that display parent-of-origin effects (POE) may play a si …
BACKGROUND: Genetic factors contribute, in part, to fetal growth restriction (FGR), a developmental condition of disrupted fetal development …
Intervention mapping to develop a patient-advocate enhanced program to reduce sedentary behavior in endometrial cancer survivors.
Bates-Fraser LC, Rouse A, Bae-Jump VL, Meyer ML, Moore JB, Muss HB, Battaglini CL, Stoner L, Hanson ED. Bates-Fraser LC, et al. J Cancer Surviv. 2026 Apr 10. doi: 10.1007/s11764-026-02009-1. Online ahead of print. J Cancer Surviv. 2026. PMID: 41961196
Patient advocate input refined the intervention, which incorporates self-monitoring with wearables, small group health coaching, and a smartphone app to support engagement. CONCLUSIONS: Patient advocates identified more facilitators than barriers to the proposed interventi …
Patient advocate input refined the intervention, which incorporates self-monitoring with wearables, small group health coaching, and …
IBD risk locus rs1077773 enhances aryl hydrocarbon receptor activity and modulates immune cell function in vitro.
King AC, Seiler K, Swanson K, Ciorba MA, Alvarado DM. King AC, et al. Inflamm Res. 2026 Apr 10;75(1):88. doi: 10.1007/s00011-026-02236-3. Inflamm Res. 2026. PMID: 41961102 Free PMC article.
Cytokine levels in culture supernatant were measured via using the ProcartaPlex human cytokine, chemokine, and growth factor 45-plex (ThermoFisher) on a Luminex FLEXMAP3D instrument. ...
Cytokine levels in culture supernatant were measured via using the ProcartaPlex human cytokine, chemokine, and growth factor 45-plex …
Loss of ZNRF3/RNF43 unleashes EGFR in cancer.
Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y. Yue F, et al. Elife. 2026 Apr 10;13:RP95639. doi: 10.7554/eLife.95639. Elife. 2026. PMID: 41960900 Free PMC article.
However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, l …
However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple …
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.
Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Ho-Tieng D, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, Zhao HT, Fitzsimmons B, Gkogkas CG, Sonenberg N, Price TJ, Diatchenko L, Atlasi Y, Mogil JS, Khoutorsky A. Lister KC, et al. Elife. 2026 Apr 10;13:RP100451. doi: 10.7554/eLife.100451. Elife. 2026. PMID: 41960785 Free PMC article.
Factors That Facilitate and Hinder Historically Black Colleges and Universities Faculty Research Success.
Hall NM, Boyer CB, Gonzales M, Green-Ajufo B, Arnold EA. Hall NM, et al. J Divers High Educ. 2026 Jan 19:10.1037/dhe0000709. doi: 10.1037/dhe0000709. Online ahead of print. J Divers High Educ. 2026. PMID: 41960567 Free PMC article.
Historically Black Colleges and Universities (HBCUs) have made a substantial impact on their students, surrounding communities, and on the local, regional, and national economies. Despite their long-standing commitment to educating and training Black students, HBCUs face c …
Historically Black Colleges and Universities (HBCUs) have made a substantial impact on their students, surrounding communities, and on the l …
Limited cancer health literacy rates and factors associated with cancer health literacy in persons with or without a cancer diagnosis.
Dumenci L, Riddle DL. Dumenci L, et al. Health Lit Commun Open. 2026;4(1):10.1080/28355245.2026.2641290. doi: 10.1080/28355245.2026.2641290. Epub 2026 Mar 17. Health Lit Commun Open. 2026. PMID: 41960553 Free PMC article.
BACKGROUND: Health literacy is a key factor for health communication efforts. This is especially true for preventing noncommunicable chronic diseases such as cancer. ...METHODS: Data from cancer patients (N=1,306) and those without cancer (N=512) collected from the …
BACKGROUND: Health literacy is a key factor for health communication efforts. This is especially true for preventing noncommun …
Comparative Phytochemical Profiling and Wound Healing Potential of Scabiosa pseudograminifolia Hub.-Mor. and Scabiosa hololeuca Bornm.: UHPLC-HRMS/MS Analysis and Fibroblast-Based Evaluation.
Öğüt K, Tilki EK, Cerezo AB, Soyer P, Baysal M, Özek T. Öğüt K, et al. Food Sci Nutr. 2026 Apr 8;14(4):e71738. doi: 10.1002/fsn3.71738. eCollection 2026 Apr. Food Sci Nutr. 2026. PMID: 41960359 Free PMC article.
Methanolic and aqueous extracts were analyzed for their phenolic constituents and evaluated in NIH/3T3 fibroblasts for intracellular reactive oxygen species (ROS) modulation, cell viability, and wound healing activity. ...
Methanolic and aqueous extracts were analyzed for their phenolic constituents and evaluated in NIH/3T3 fibroblasts for intracellular …
Diffusion Policies with Offline and Inverse Reinforcement Learning for Promoting Physical Activity in Older Adults Using Wearable Sensors.
Liu C, Thiamwong L, Fu Y, Xie R. Liu C, et al. Proc Int Conf Mach Learn Appl. 2025 Dec;2025:275-282. doi: 10.1109/icmla66185.2025.00043. Epub 2026 Apr 7. Proc Int Conf Mach Learn Appl. 2025. PMID: 41960140 Free PMC article.
Offline RL also encounters distributional discrepancies between learned policies and observed human behavior, a critical issue in healthcare applications. To address challenges in applying offline RL to physical activity promotion for older adults at high risk of falls, ba …
Offline RL also encounters distributional discrepancies between learned policies and observed human behavior, a critical issue in hea …
Targeting noncanonical TGF-beta signaling: inhibition effects on the human keloid fibroblast transcriptome.
Morningstar J, Sivadas A, Romeo M, Vaena S, Valdebran M, Kwatra SG, Norris RA, Beck TC. Morningstar J, et al. Itch (Phila). 2025 Oct-Dec;10(4):e0084. doi: 10.1097/itx.0000000000000084. Epub 2025 Dec 22. Itch (Phila). 2025. PMID: 41959884 Free PMC article.
In this study, we investigated the effects of selective MEK1 inhibition in vitro using NL350-02 on human keloid fibroblasts via bulk RNA sequencing. Treatment with NL350-02 induced substantial transcriptomic reprogramming, including downregulation of TGF-beta receptors, IL …
In this study, we investigated the effects of selective MEK1 inhibition in vitro using NL350-02 on human keloid fibroblasts via bulk …
Evaluation of non-sputum-based diagnostics for pediatric tuberculosis: the Pediatric TB Diagnostic (PDTBDx) cohort protocol.
Mullen B, Githua J, Escudero JN, Mecha J, Kijaro L, Ndunge M, Muriithi M, Kibet I, John-Stewart G, Maleche-Obimbo E, Nduba V, LaCourse SM. Mullen B, et al. medRxiv [Preprint]. 2026 Apr 3:2026.04.01.26350011. doi: 10.64898/2026.04.01.26350011. medRxiv. 2026. PMID: 41959800 Free PMC article. Preprint.
Enrolled participants will undergo rigorous clinical assessment and longitudinal follow-up to ensure appropriate diagnostic classification by NIH consensus statement guidelines for pediatric TB. Baseline evaluation includes symptom assessment, chest x-ray, HIV testing, res …
Enrolled participants will undergo rigorous clinical assessment and longitudinal follow-up to ensure appropriate diagnostic classification b …
Client and Health Care Provider Perspectives on Point-of-Care Testing for Sexually Transmitted Infections in Community Pharmacies in Uganda.
Onzia AA, Twimukye A, Melendez JH, Hamill MM, Kyambadde P, Kiragga A, Manabe YC, Parkes-Ratanshi R. Onzia AA, et al. medRxiv [Preprint]. 2026 Apr 3:2026.04.02.26350027. doi: 10.64898/2026.04.02.26350027. medRxiv. 2026. PMID: 41959787 Free PMC article. Preprint.
Barriers to POC testing included a lack of awareness among clients and health workers, inadequate privacy and space, long wait times, unclear self-sample collection instructions, stigma around HIV testing, and reluctance to test for STIs beyond HIV. ...Integrating POC test …
Barriers to POC testing included a lack of awareness among clients and health workers, inadequate privacy and space, long wait times, …
A Manual of Procedures for the Generation of the AI-Ready and Exploratory Atlas for Diabetes Insights (AI-READI) Database.
Matthies DS, Edberg JC, Baxter SL, Lee AY, Lee CS, McGwin G, Owen JP, Zangwill LM, Owsley C. Matthies DS, et al. medRxiv [Preprint]. 2026 Apr 4:2026.03.30.26349552. doi: 10.64898/2026.03.30.26349552. medRxiv. 2026. PMID: 41959775 Free PMC article. Preprint.
The ability to understand and affect the course of complex, multi-system diseases like diabetes has been limited by a lack of well-designed, high-quality and large multimodal datasets. The NIH Bridge2AI AI-READI project ( aireadi.org ) aims to address this shortfall by gen …
The ability to understand and affect the course of complex, multi-system diseases like diabetes has been limited by a lack of well-designed, …
COVID-19 Vaccine Acceptance among People who Smoke in Rural Southwest Georgia: Perspectives and Influencing Factors.
Owolabi S, Singer H, Reilly K, Bundy LT, Veluswamy JK, Berg C, Haardörfer R, Hotz J, Gehlot A, Kegler M. Owolabi S, et al. J Ga Public Health Assoc. 2025 Fall;11(1):7. J Ga Public Health Assoc. 2025. PMID: 41959730 Free PMC article.
Unfortunately, vaccine hesitancy is an ongoing public health challenge, especially in certain geographic areas and sub-populations. This study assessed factors associated with COVID-19 vaccine uptake and hesitancy among individuals who smoke in rural communities in southwe …
Unfortunately, vaccine hesitancy is an ongoing public health challenge, especially in certain geographic areas and sub-populations. T …
Is there evidence for the Bruce effect in white-faced capuchins?
Petersdorf M, Brasington LF, Kulick NK, Buehler MS, Hernandez SC, Fedigan LM, Navarro RL, Melin AD, Campos FA, Jack KM. Petersdorf M, et al. Anim Behav. 2025 Nov;229:123316. doi: 10.1016/j.anbehav.2025.123316. Epub 2025 Sep 24. Anim Behav. 2025. PMID: 41959698 Free PMC article.
Finally, the evolution of female reproductive strategies may not be labile enough that it can be predicted from population-specific social and demographic patterns without regard to phylogenetic constraints. More studies are needed to understand the conditions that determi …
Finally, the evolution of female reproductive strategies may not be labile enough that it can be predicted from population-specific socia …
A healthy dose of skepticism: The relationship between young adolescents' sexual media exposure and sexual intentions, and the moderating role of media skepticism.
Dodson CV, Evans-Paulson R, Scull TM. Dodson CV, et al. Psychol Pop Media. 2026 Apr 6:10.1037/ppm0000667. doi: 10.1037/ppm0000667. Online ahead of print. Psychol Pop Media. 2026. PMID: 41959692 Free PMC article.
Research has emphasized the potential role of individual-difference variables in attenuating the potentially unhealthy impact of media on adolescent sexual health outcomes, and scholars have called for additional research in this area. Skepticism of media messages has been …
Research has emphasized the potential role of individual-difference variables in attenuating the potentially unhealthy impact of media on ad …
Activation and execution of lipoxygenase catalysis.
Brash AR, Oliw EH. Brash AR, et al. Redox Biochem Chem. 2026 Jun;16:100076. doi: 10.1016/j.rbc.2026.100076. Epub 2026 Mar 24. Redox Biochem Chem. 2026. PMID: 41959689 Free PMC article.
VesSynth: Tubes Are All You Need for Robust Cross-Scale Cross-Modal 3D Vessel Segmentation.
Mauri C, Mckenzie A, Analoro C, Yeon E, Coviello R, Mora J, Chollet E, Deden Binder L, Mahar A, Lin S, Benlahcen M, Ream A, Jama A, Garcia I, Tran N, Onta P, Wood S, Willis A, Mahmood A, Sinoballa G, Malki A, Tran K, Malireddy V, Onumajuru N, Lakshmanan S, Hercules Landaverde K, Sidow R, Wood D, Nguyen B, Hernandez J, Bernier M, Hunter J, Malki A, Tum A, Chavez V, Shahu Z, Vasi I, Visser A, Ghaouta Z, Bond F, Vigneshwaran R, Kirkpatrick E, Avalos Barbosa M, Rauh K, Herisse R, Garcia Pallares E, Zeng X, Varadarajan D, Wang H, Magnain C, Edlow BL, Hoffmann M, Fischl B, Balbastre Y. Mauri C, et al. bioRxiv [Preprint]. 2026 Apr 5:2026.04.01.715909. doi: 10.64898/2026.04.01.715909. bioRxiv. 2026. PMID: 41959422 Free PMC article. Preprint.
By enabling consistent vascular mapping across scales, this framework paves the way to comprehensive investigation of cerebrovascular organization and its role in health and disease....
By enabling consistent vascular mapping across scales, this framework paves the way to comprehensive investigation of cerebrovascular organi …
Pharmacologic DPP-4 inhibition promotes CD8⁺ T cell metabolic fitness to enhance anti-tumor activity.
Teran Pumar OY, VanNoy EL, Haffey A, Gannamedi DP, Rafie CI, Lykke Harwood DS, Benedetti JR, Pittman Ballard CA, Ciervo E, Assenza Tavares Coroa PH, Grover P, León BE, Mitchell J, Pathak A, Colon B, El Ghorayeb L, O'Sullivan L, Venkatarame Gowda Saralamma V, Lopez Ruiz C, Khatwani N, Kumar S, Rai P, Schatz J, Shah A, Binder ZA, Ceccarelli M, Ostrom QT, Kristensen BW, Stelekati E, Watson DC, Lombard DB, Haydar D, Bayik D. Teran Pumar OY, et al. bioRxiv [Preprint]. 2026 Apr 3:2026.03.31.715681. doi: 10.64898/2026.03.31.715681. bioRxiv. 2026. PMID: 41959339 Free PMC article. Preprint.
Chemical Proteomic Profiling of the Histaminylation Proteome in Cancer Cells Unveils Uncharted Epigenetic Marks on Core Histones.
Ma X, Leaman AA, Lin Z, Li H, Cai Z, Dalal K, Hossain MS, Thirumalaikumar VP, Wang Z, O'Brien VP, Tao WA, Zheng Q. Ma X, et al. bioRxiv [Preprint]. 2026 Mar 10:2026.03.07.710331. doi: 10.64898/2026.03.07.710331. bioRxiv. 2026. PMID: 41959267 Free PMC article. Preprint.
Histamine is a key signaling molecule in pathophysiology that can exhibit significant regulatory roles in diverse health and disease status. Besides the well-studied noncovalent interactions between histamine and its receptors, protein histaminylation is a recently discove …
Histamine is a key signaling molecule in pathophysiology that can exhibit significant regulatory roles in diverse health and disease …
Multi-omic profiling of human and mouse dorsal root ganglia enables targeted gene delivery to nociceptors.
He LS, Bhatia P, Bhuiyan SA, Semizoglou E, Wang J, Li J, Nam J, Luo JXJ, Arnhold C, Zhu D, Xu M, Griesemer D, Yong HJ, Jayne L, Gilmer E, Li Q, Pantaleo K, Yang L, Williams EK, Jayakar S, Wainger BJ, Hrvatin S, Renthal W; NIH PRECISION Human Pain Network. He LS, et al. bioRxiv [Preprint]. 2026 Mar 12:2026.03.05.709931. doi: 10.64898/2026.03.05.709931. bioRxiv. 2026. PMID: 41959226 Free PMC article. Preprint.
Here, we combined single-nucleus multi-omic profiling of human and mouse DRG with in vivo AAV enhancer screening to identify cis -regulatory elements that drive biased AAV expression in mouse DRG nociceptors and human iPSC-derived nociceptors. ...
Here, we combined single-nucleus multi-omic profiling of human and mouse DRG with in vivo AAV enhancer screening to identify cis -reg …
STAR Suite: Integrating transcriptomics through AI software engineering in the NIH MorPhiC consortium.
Hung LH, Yeung KY. Hung LH, et al. bioRxiv [Preprint]. 2026 Mar 10:2026.03.09.710580. doi: 10.64898/2026.03.09.710580. bioRxiv. 2026. PMID: 41959219 Free PMC article. Preprint.
These limitations presented scalability problems for uniform processing of data in the NIH MorPhiC consortium. We present our solution, STAR Suite, a human-engineered and AI-implemented modernization that integrates functionality directly into the C++ source. ...
These limitations presented scalability problems for uniform processing of data in the NIH MorPhiC consortium. We present our solutio …
Insights from recruiting individuals with mild dementia and care partners for a multi-site oral hygiene intervention.
Wang J, Siamdoust S, Xu Z, Mott C, Plassman BL, Anderson RA, Zwerling J, Wu B. Wang J, et al. Aging Health Res. 2025 Sep;5(3):100236. doi: 10.1016/j.ahr.2025.100236. Epub 2025 May 28. Aging Health Res. 2025. PMID: 41958914 Free PMC article.
BACKGROUND: Maintaining oral health is essential for individuals with dementia, yet they often need support. We sought to identify insights gained during the recruitment process for an intervention designed to teach care partners skills to guide individuals with mild demen …
BACKGROUND: Maintaining oral health is essential for individuals with dementia, yet they often need support. We sought to identify in …
Surrogate Perspectives on the Communication and Support Processes That Enable Them as Active Decision-Makers Across Chronic Critical Illness.
Moale AC, White DB, McVerry BJ, Grier R, Kurukulasuriya CE, Layshock MN, Cheng S, Arnold RM, Ragavan MI, Boss RD, Chang JC. Moale AC, et al. CHEST Crit Care. 2026 Mar;4(1):100220. doi: 10.1016/j.chstcc.2025.100220. Epub 2026 Feb 11. CHEST Crit Care. 2026. PMID: 41958891 Free PMC article.
RESULTS: We interviewed 23 surrogate decision-makers of 19 medical and surgical patients with moderate-high illness severity (mean Acute Physiology and Chronic Health Evaluation II score, 21.5 5.3). Five themes were generated from family perspectives, representing the es …
RESULTS: We interviewed 23 surrogate decision-makers of 19 medical and surgical patients with moderate-high illness severity (mean Acute Phy …
Ammonia monooxygenase: a work in progress.
Arndt TC, Laughlin AL, Lancaster KM. Arndt TC, et al. Chem Sci. 2026 Apr 8. doi: 10.1039/d6sc01048b. Online ahead of print. Chem Sci. 2026. PMID: 41958861 Free PMC article. Review.
Non-Medical Barriers in Access to Kidney Transplantation: Perspectives from Dialysis and Transplant Center Staff Across Four US Regions.
Buford J, Wilk AS, Harding JL, Di M, Urbanski M, Blythe E, Pastan SO, Patzer RE. Buford J, et al. J Nephrol Soc Work. 2026;50(1):203. Epub 2026 Feb 18. J Nephrol Soc Work. 2026. PMID: 41958806 Free PMC article.
Two comparable surveys assessed perceived access barriers among dialysis and transplant center staff across New England, New York, U.S. Southeast, and Ohio River Valley (August 2021-October 2023). Among 630 dialysis and 34 transplant staff/centers, dialysis staff mo …
Two comparable surveys assessed perceived access barriers among dialysis and transplant center staff across New England, New York, U. …
3,508,306 results
You have reached the last available page of results. Please see the User Guide for more information.