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2018 25
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Adolescent disordered eating and epigenetic age acceleration.
Curtis M, Balfour D, Melton P, Lin A, Kleinig Z, Cohen-Woods S. Curtis M, et al. Mol Psychiatry. 2026 Apr 10. doi: 10.1038/s41380-026-03595-3. Online ahead of print. Mol Psychiatry. 2026. PMID: 41963675
Disordered eating is associated with a range of poor health outcomes that affect various body systems, including immune, metabolic, and stress-related processes. ...The association between age 14 restriction and DunedinPACE was partially mediated through higher BMI at ages …
Disordered eating is associated with a range of poor health outcomes that affect various body systems, including immune, metabolic, a …
Elucidating the roles of microRNA-103a-3p in trophoblast invasion and SOX4-mediated extravillous differentiation induced by activin A.
Xie J, Shannon MJ, Zhu H, Dong M, Beristain AG, Leung PCK. Xie J, et al. Cell Death Dis. 2026 Apr 10. doi: 10.1038/s41419-026-08665-6. Online ahead of print. Cell Death Dis. 2026. PMID: 41963302 Free article.
Activin A, a growth factor detectable in serum that belongs to the transforming growth factor-beta (TGF-beta) superfamily, has been implicated in the development of preeclampsia, as evidenced by its elevated serum levels and its role in regulating trophoblast invasion. However, t …
Activin A, a growth factor detectable in serum that belongs to the transforming growth factor-beta (TGF-beta) superfamily, has been implicat …
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F. Chana CK, et al. Nat Chem Biol. 2026 Apr 9. doi: 10.1038/s41589-026-02183-4. Online ahead of print. Nat Chem Biol. 2026. PMID: 41957281
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice.
Kim EC, Jung HB, Park YK, Son Y, Cha HN, Patel Y, Lee JH, Choi M, Park S, Kim IK, Pickel L, Lee S, Ha Y, Shin MG, Zhang Q, Yang J, de Oliveira BR, Vo N, Yew A, Togo J, Ealey KN, Jung SR, Moon S, Yoon HJ, Lee JY, Sung HK, Kim JR, Park SY. Kim EC, et al. Nat Commun. 2026 Mar 31;17(1):2700. doi: 10.1038/s41467-026-70475-3. Nat Commun. 2026. PMID: 41916993 Free PMC article.
Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.
Callaghan NI, Durland LJ, Chen W, Kuzmanov U, Miranda MZ, Ding Y, Mirzaei Z, Ireland RG, Reitz C, Gorman RA, Wang EY, Wagner K, Kim MM, Audet J, Santerre JP, Gramolini AO, Billia F, Radisic M, Mital S, Ellis J, Backx PH, Simmons CA. Callaghan NI, et al. Nat Commun. 2026 Mar 31. doi: 10.1038/s41467-026-70550-9. Online ahead of print. Nat Commun. 2026. PMID: 41916979 Free article.
Understanding depression through an intersectional framework: the joint impact of childhood adversities and social determinants using Canadian longitudinal study on aging (CLSA) data.
Su Y, Li M, Fleury MJ, Adams GC, Meng X. Su Y, et al. Transl Psychiatry. 2026 Apr 1;16(1):227. doi: 10.1038/s41398-026-03973-z. Transl Psychiatry. 2026. PMID: 41916947 Free PMC article.
While previous research has focused on individual risk factors, few studies have utilized an intersectionality-informed framework to examine how multiple social factors collectively impact depression risk, particularly in the context of childhood adversities. This study in …
While previous research has focused on individual risk factors, few studies have utilized an intersectionality-informed framework to …
Associations of health-related fitness and physical activity with chemotherapy outcomes in breast cancer.
Kokts-Porietis RL, Morielli AR, Yang L, Matthews CE, Lupichuk S, Roldan-Urgoiti G, McNeely ML, Culos-Reed SN, Vallance JK, Dickau L, Courneya KS, Friedenreich CM. Kokts-Porietis RL, et al. Br J Cancer. 2026 Mar 27. doi: 10.1038/s41416-026-03384-3. Online ahead of print. Br J Cancer. 2026. PMID: 41896651
BACKGROUND: Limited research exists on how modifiable lifestyle factors influence tolerability and response to chemotherapy. We investigated the associations between health-related fitness, physical activity, and sedentary behaviour after diagnosis with relative dos …
BACKGROUND: Limited research exists on how modifiable lifestyle factors influence tolerability and response to chemotherapy. We inves …
Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm.
Li X, Qureshi MNI, Laplante DP, Elgbeili G, Jones SL, King S, Rosa-Neto P. Li X, et al. Transl Psychiatry. 2026 Mar 19;16(1):184. doi: 10.1038/s41398-026-03918-6. Transl Psychiatry. 2026. PMID: 41856988 Free PMC article.
Given these links between brain and autistic-like traits, future research should examine whether brain volumes and connectivity mediate associations between PNMS and autistic-like traits in young adulthood....
Given these links between brain and autistic-like traits, future research should examine whether brain volumes and connectivity media …
Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors.
Misra PS, McGaugh EC, Huang H, Cho A, Lin J, Sarangi F, Oakie A, Sambathkumar R, Song Y, Fabríciová V, Bohuslavová R, Pavlínková G, Nostro MC. Misra PS, et al. Nat Commun. 2026 Mar 18. doi: 10.1038/s41467-026-70666-y. Online ahead of print. Nat Commun. 2026. PMID: 41851084 Free article.
In addition to expanding our understanding of pancreatic endocrine lineage allocation and identity, these findings establish a logical differentiation framework to guide the generation of designer hPSC-islets for research and therapeutic applications....
In addition to expanding our understanding of pancreatic endocrine lineage allocation and identity, these findings establish a logical diffe …
Ureteral stent sleeve for early detection of hydronephrosis.
Shalabi N, Searles K, Herout R, Almutairi K, Chew BH, Lange D, Takahata K. Shalabi N, et al. Microsyst Nanoeng. 2026 Mar 18;12(1):97. doi: 10.1038/s41378-026-01224-1. Microsyst Nanoeng. 2026. PMID: 41844604 Free PMC article.
Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution.
N'Guessan A, Wang V, Bakerlee CW, Belousova J, Brenna GY, Dillingham ME, Gopalakrishnan S, Goyal J, Gupta M, Holmes CM, Humphrey PT, Jagdish T, Jerison ER, Johnson MS, Kosheleva K, Lawrence KR, Min J, Moulana A, Pai SV, Phillips AM, Piper JC, Purkanti R, Rego-Costa A, Ruiz-Bedoya T, Trivellin C, McDonald MJ, Desai MM, Nguyen Ba AN. N'Guessan A, et al. Nat Ecol Evol. 2026 Mar 13. doi: 10.1038/s41559-026-03017-1. Online ahead of print. Nat Ecol Evol. 2026. PMID: 41826490
Deciphering the causal influence of BMI and related metabolic, inflammatory, and cardiovascular factors on brain structure: a Mendelian Randomization Study.
Painter JN, Refisch A, Rau M, Walter M, Mackey S, Laurent J, Thompson PM, Grasby KL, Hajek T, Medland SE, Opel N. Painter JN, et al. Mol Psychiatry. 2026 Mar 9. doi: 10.1038/s41380-026-03501-x. Online ahead of print. Mol Psychiatry. 2026. PMID: 41803379
Obesity has frequently been shown to affect brain physiology at multiple levels, and to increase the risk for the development of neuropsychiatric disorders such as major depression and dementia. Previous large-scale neuroimaging research has consistently shown overlapping …
Obesity has frequently been shown to affect brain physiology at multiple levels, and to increase the risk for the development of neuropsychi …
"Where do I go from here?" Navigating a lifelong road without a map: the care experiences of hereditary cancer patients.
Butkowsky C, Carroll JC, Aronson M, Sam J, Reble E, Clausen M, Gopalakrishnan R, Sparkes B, Rajeziesfahani S, Aguda V, Bishop D, Dawson L, Eisen A, Graham T, Green J, Mighton C, Pauling J, Pavao C, Pechlivanoglou P, Remocker C, Sun S, Tiano T, Tilley A, Thorpe K, Schrader K, Etchegary H, Bombard Y. Butkowsky C, et al. Eur J Hum Genet. 2026 Mar 3. doi: 10.1038/s41431-026-02069-y. Online ahead of print. Eur J Hum Genet. 2026. PMID: 41776346
HCS patients were purposely sampled from cancer/genetic clinics across three Canadian provinces to reflect demographic and clinical variations. Data collection included qualitative, semi-structured interviews. ...
HCS patients were purposely sampled from cancer/genetic clinics across three Canadian provinces to reflect demographic and clinical v …
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.
Fisher K, Garcia MA, Frattari GS, Naasz C, Zhuo J, Rosás-Umbert M, Dietz LL, Juhl AK, Falling Iversen E, Olesen R, Schleimann MH, Pahus MH, Johansen IS, Henderson M, Carrere L, Roseto I, Gao C, Yu XG, Fray EJ, Aydin B, Lubbeck D, Lai J, Simonetti FR, Danesh A, Miller I, Mendoza P, Niessl J, Gaebler C, Seaman MS, Kaufmann DE, Lehmann C, Gruell H, Klein F, Caskey M, Nussenzweig MC, Tolstrup M, Jones RB, Gunst JD, Siliciano JD, Lichterfeld M, Siliciano RF, Søgaard OS. Fisher K, et al. Nat Immunol. 2026 Apr;27(4):812-826. doi: 10.1038/s41590-026-02448-z. Epub 2026 Mar 3. Nat Immunol. 2026. PMID: 41776101 Free PMC article.
The conceptual landscape of self-regulation in neurodevelopmental conditions: an overview of reviews.
Iturmendi-Sabater I, Jain S, Turcany-Diaz S, Besa R, Anagnostou E, Fournier MA, Lin HY, Lai MC. Iturmendi-Sabater I, et al. Nat Hum Behav. 2026 Mar 2. doi: 10.1038/s41562-026-02410-x. Online ahead of print. Nat Hum Behav. 2026. PMID: 41772057
Risk of bias assessed through the Joanna Briggs Institute checklist revealed methodological heterogeneity. This overview of reviews offers guidance for aligning research, assessments and interventions with a domain-general, developmental understanding of self-regula …
Risk of bias assessed through the Joanna Briggs Institute checklist revealed methodological heterogeneity. This overview of reviews o …
Prospective multicenter study of ctDNA versus tumor tissue guiding FGFR-targeted therapy in metastatic urothelial cancer.
Müller DC, Murtha AJ, Bacon JVW, Stephenson M, Wells C, Vasquez-Rios C, Rostin K, Rebane L, Schönlau E, Nikkola J, Alimohamed N, Basappa NS, Finch D, Ko JJ, Lavoie JM, Nappi L, Noonan K, Ong M, Ozgun G, Parimi S, Soleimani M, Sridhar SS, Toren P, Winquist E, Bernales CQ, Koudjanian M, Atwal J, Fung E, Khan L, Eigl B, Othman D, Bismar TA, Wang G, Merza R, Papadakis AI, Spatz A, Kollmannsberger C, Maurice-Dror C, Annala M, Chi KN, Vandekerkhove G, Wyatt AW, Eigl BJ. Müller DC, et al. Nat Commun. 2026 Feb 27;17(1):3263. doi: 10.1038/s41467-026-69927-7. Nat Commun. 2026. PMID: 41760649 Free PMC article.
Pharmacogenomics of antiepileptic drug mood stabilizer treatment response in bipolar disorder: A MoStGen Consortium study.
Ho AM, Coombes BJ, Batzler A, Pazdernik VK, Pendegraft RS, Skime M, Bendjemaa N, Carpiniello B, Contu M, Dalkner N, Fellendorf FT, Fico G, Fullerton CD, Gardea-Resendez M, Gonzalez-Garza S, Jaafari N, Jiménez E, Kebir O, Legrand A, Luna-Garza S, Meloni A, Millet B, Mouaffak F, Nunes A, O'Donovan C, Paribello P, Pinna M, Pisanu C, Pomarol-Clotet E, Romo-Nava F, Sánchez RF, Scott K, Squassina A, Vilella E, Serretti A, Prieto ML, Reininghaus EZ, Bengesser SA, Cuellar-Barboza AB, Krebs MO, Chaumette B, Vieta E, Manchia M, McElroy SL, Alda M, Frye MA, Biernacka JM. Ho AM, et al. Mol Psychiatry. 2026 Feb 19. doi: 10.1038/s41380-026-03478-7. Online ahead of print. Mol Psychiatry. 2026. PMID: 41714438
Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease.
Jacquemyn J, Marriott B, Chang J, Iftikhar E, Chik K, Lee NYJ, Rubio Atonal LF, Green C, Wong J, Acevedo-Morantes C, Chen CX, Nicouleau M, You Z, Deneault E, Abdian N, Durcan TM, Jackson J, Ioannou MS. Jacquemyn J, et al. Nat Cell Biol. 2026 Mar;28(3):492-506. doi: 10.1038/s41556-026-01871-6. Epub 2026 Feb 12. Nat Cell Biol. 2026. PMID: 41680444
The Habenula's role in major depressive disorder: recent insights from preclinical and human studies.
Lin F, Casmey K, Codeluppi-Arrowsmith SA, Turecki G. Lin F, et al. Transl Psychiatry. 2026 Feb 7;16(1):77. doi: 10.1038/s41398-026-03867-0. Transl Psychiatry. 2026. PMID: 41654494 Free PMC article. Review.
Structural imaging and postmortem neurohistological studies in MDD patients have further revealed habenular volume changes, reduced neuronal cell counts, diminished cell area, and abnormal functional connectivity. As research unravels the habenula's complexities, its poten …
Structural imaging and postmortem neurohistological studies in MDD patients have further revealed habenular volume changes, reduced neuronal …
The Nugent score is an inappropriate diagnostic tool for neovaginal bacteria in transfeminine people.
Parmar R, Monari B, Potter E, Rojas-Vargas J, Wilcox H, Zuanazzi D, Poon A, Shouldice AC, Edwards VL, Krakowsky Y, Ravel J, Prodger JL. Parmar R, et al. Commun Med (Lond). 2026 Feb 3;6(1):136. doi: 10.1038/s43856-026-01410-2. Commun Med (Lond). 2026. PMID: 41634193 Free PMC article.
CONCLUSIONS: The Nugent score is not an effective tool to identify neovaginal dysbiosis or indicators of health in transfeminine individuals. Clinicians need the development of accurate, evidence-based diagnostic tools for the neovagina. ...
CONCLUSIONS: The Nugent score is not an effective tool to identify neovaginal dysbiosis or indicators of health in transfeminine indi …
A multi-ancestry genetic reference for the Quebec population.
McClelland P, Femerling G, Laflamme R, Mejia-Garcia A, Sayahian Dehkordi M, Xiao H, Diaz-Papkovich A, Pelletier J, Grenier JC, Lo KS, Anderson-Trocmé L, Bellavance J, Chapdelaine V, Gagnon G, De Mori A, Martinez G, Mohler K, de Malliard T, Labbé C, Labrecque M, Montpetit A, Spiegelman D, Rouleau GA, Théroux JF, Zhou H, Girard SL, Hussin JG, Laberge AM, Bhérer C, Tetreault M, Gagliano Taliun SA, Taliun D, Gravel S, Lettre G. McClelland P, et al. Nat Commun. 2026 Feb 3;17(1):1319. doi: 10.1038/s41467-026-68820-7. Nat Commun. 2026. PMID: 41634041 Free PMC article.
While international efforts have characterized genetic variation in millions of individuals, the interplay of environmental, social, cultural and genetic factors is poorly understood for most worldwide populations. The province of Quebec in Canada has been the site of nume …
While international efforts have characterized genetic variation in millions of individuals, the interplay of environmental, social, cultura …
Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium.
Farncombe KM, Sobotka JA, Aronson M, Basik M, Bombard Y, Born L, Cheifetz R, Clausen M, Coburn N, Dawson L, Doria AS, Elbanna KY, Etchegary H, Foulkes WD, Hessels C, Hyde A, Kazazian K, Kinnaird A, Koch CA, Laframboise S, Lerner-Ellis J, Lheureux S, Malkin D, Metser U, Penney LS, Ridd S, Schrader KA, Tiano T, Tone AA, Veit-Haibach P, Wong S, Xu W, Pugh TJ, Kim RH. Farncombe KM, et al. Eur J Hum Genet. 2026 Jan 29. doi: 10.1038/s41431-026-02014-z. Online ahead of print. Eur J Hum Genet. 2026. PMID: 41611967 Review.
Our goal is to inform if and how cfDNA analysis could be implemented into routine clinical care and offer a path to equitable and more convenient cancer screening for all high-risk Canadians....
Our goal is to inform if and how cfDNA analysis could be implemented into routine clinical care and offer a path to equitable and more conve …
Tutorial: annotation of animal genomes.
Clarke ZA, Sokolowski DJ, Byles-Ho CK, Isserlin R, Wilson MD, Simpson JT, Bader GD. Clarke ZA, et al. Nat Protoc. 2026 Jan 28. doi: 10.1038/s41596-025-01301-1. Online ahead of print. Nat Protoc. 2026. PMID: 41606128 Review.
Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.
Bocher O, Arruda AL, Yoshiji S, Zhao C, Huerta-Chagoya A, Su CY, Yin X, Cammann D, Taylor HJ, Chen J, Suzuki K, Mandla R, Yang TY, Matsuda F, Mercader JM, Flannick J, Meigs JB, Wood AC, Vujkovic M, Voight BF, Spracklen CN, Rotter JI, Morris AP, Zeggini E. Bocher O, et al. Nat Metab. 2026 Feb;8(2):506-520. doi: 10.1038/s42255-025-01444-1. Epub 2026 Jan 27. Nat Metab. 2026. PMID: 41593238 Free PMC article.
Exploring and visualizing stratified GWAS results with PheWeb2.
Bellavance J, Xiao H, Chang L, Kazemi M, Wickramasinghe S, Mayhew AJ, Raina P, VandeHaar P, Taliun D, Gagliano Taliun SA. Bellavance J, et al. Nat Genet. 2026 Feb;58(2):233-235. doi: 10.1038/s41588-025-02469-8. Nat Genet. 2026. PMID: 41555088 No abstract available.
Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging.
Vishnyakova O, Min J, Leach S, Song X, Rockwood K, Brooks-Wilson A, Elliott LT. Vishnyakova O, et al. Commun Med (Lond). 2026 Jan 10;6(1):110. doi: 10.1038/s43856-026-01375-2. Commun Med (Lond). 2026. PMID: 41520049 Free PMC article.
METHODS: We have developed a metabolomic predictor of biological age based on untargeted metabolomic profiling of individuals aged 45-85 years from the Canadian Longitudinal Study on Aging. To enhance interpretability, we first identified metabolites related to health …
METHODS: We have developed a metabolomic predictor of biological age based on untargeted metabolomic profiling of individuals aged 45-85 yea …
Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial.
Rose AAN, Maxwell J, Rousselle E, Mukonoweshuro CL, Elkholi IE, Riaud M, Biondini M, Cianfarano E, Soria-Bretones I, Tobin C, McGuire M, Law RWY, Elia AJ, Wang BX, King I, Zhang T, Pugh TJ, Kamil ZS, Butler M, Shepherd FA, Leighl NB, Razak AA, Hansen A, Saibil SD, Bedard PL, Siegel PM, Siu LL, Cescon DW, Spreafico A. Rose AAN, et al. Nat Commun. 2026 Jan 3;17(1):1323. doi: 10.1038/s41467-025-68076-7. Nat Commun. 2026. PMID: 41484121 Free PMC article. Clinical Trial.
A systematic review and meta-analysis of disease clusters in multimorbidity.
Ferris JK, Fiedeldey LK, Kim B, Clemens F, Irvine MA, Hosseini SH, Smolina K, Wister A. Ferris JK, et al. Nat Commun. 2025 Dec 26;17(1):634. doi: 10.1038/s41467-025-67372-6. Nat Commun. 2025. PMID: 41453855 Free PMC article.
No disease clusters had high stability (Jaccard 0.75) and very few accounted for disease temporality. Multimorbidity disease clustering research is heterogeneous regarding disease definitions, the number of diseases included, and clustering methodologies. ...We provide su …
No disease clusters had high stability (Jaccard 0.75) and very few accounted for disease temporality. Multimorbidity disease clustering …
Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma.
Fernandez NR, Chang Y, Nunes NM, Dimayacyac JR, Levine A, Ringel A, Negm L, Ercan AB, Hess JM, Ahmad O, Lee C, Stengs L, Bianchi V, Edwards M, Doherty S, Chung J, Nobre L, Bennett J, Dodgshun AJ, Jones DTW, Pfister SM, Villani A, Malkin D, Ramaswamy V, Huang A, Bouffet E, Aronson M, Dirks PB, Shlien A, Getz G, Maruvka YE, Ertl-Wagner B, Hawkins C, Das A, Tabori U. Fernandez NR, et al. Nat Genet. 2026 Jan;58(1):132-142. doi: 10.1038/s41588-025-02420-x. Epub 2025 Dec 22. Nat Genet. 2026. PMID: 41430480
LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2.
Kiriakopulos K, Soleimanpour K, McMurray BJ, Moke BI, Chalmers JJ, Mokhtaridoost M, Newton JD, De Young T, Delfosse K, Ahmed M, Wong CJ, Stricker S, Li Y, Nieman BJ, Gingras AC, Justice MJ, Lefebvre JL, Maass PG. Kiriakopulos K, et al. Nat Commun. 2025 Dec 16;17(1):872. doi: 10.1038/s41467-025-67591-x. Nat Commun. 2025. PMID: 41397992 Free PMC article.
Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.
Nepveu-Traversy ME, Hassanzadeh M, Bruneau-Cossette L, Besserer-Offroy É, Brouillette R, Morissette S, Traboulsi H, Kirby K, Murza A, Longpré JM, Breton B, Gendron FP, Gaudreau S, Boudreault PL, Sarret P. Nepveu-Traversy ME, et al. Nat Commun. 2025 Dec 12;16(1):11215. doi: 10.1038/s41467-025-66030-1. Nat Commun. 2025. PMID: 41387675 Free PMC article.
H3K36 Methylation as a Guardian of Epigenome Integrity.
Padilla R, Shipman GA, Horth C, Gravel M, Bareke E, Majewski J. Padilla R, et al. Nat Commun. 2025 Dec 11;16(1):11371. doi: 10.1038/s41467-025-66365-9. Nat Commun. 2025. PMID: 41381501 Free PMC article.
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses.
Oswald BM, DeCamp LM, Longo J, Dahabieh MS, Bunda N, Johnson BK, Watson MJ, Ma S, Preston SEJ, Sheldon RD, Vincent MP, Ellis AE, Soper-Hopper MT, Isaguirre C, Kamarudin D, Shen H, Williams KS, Crawford PA, Kaech S, Jang HJ, Lien EC, Krawczyk CM, Jones RG. Oswald BM, et al. Nat Metab. 2025 Dec;7(12):2489-2509. doi: 10.1038/s42255-025-01415-6. Epub 2025 Dec 9. Nat Metab. 2025. PMID: 41366157 Free PMC article.
Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.
Chilloux J, Brial F, Everard A, Smyth D, Andrikopoulos P, Zhang L, Plovier H, Myridakis A, Hoyles L, Moreno-Navarrete JM, Luque JL, Casagrande V, Menghini R, Ahmetaj-Shala B, Blancher C, Martinez-Gili L, Gencer S, Fearnside JF, Barton RH, Neves AL, Rothwell AR, Gérard C, Calderari S, Williamson MJ, Fuchs JE, Govada L, Boulangé CL, Patel S, Scott J, Thursz M, Chayen N, Glen RC, Gooderham NJ, Nicholson JK, Federici M, Fernández-Real JM, Gauguier D, Liu PP, Cani PD, Dumas ME. Chilloux J, et al. Nat Metab. 2025 Dec;7(12):2531-2547. doi: 10.1038/s42255-025-01413-8. Epub 2025 Dec 8. Nat Metab. 2025. PMID: 41361024 Free PMC article.
The global type 2 diabetes epidemic is a major health crisis. Although the microbiome has roles in the onset of insulin resistance (IR), low-grade inflammation and diabetes, the microbial compounds controlling these processes remain to be discovered. ...
The global type 2 diabetes epidemic is a major health crisis. Although the microbiome has roles in the onset of insulin resistance (I …
Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease.
Rothhaar P, Arand T, Seong HG, Heuss C, Tulessin M, Wang Z, Förster C, Schneider AC, Quistrebert J, Chai H, Reineke M, Benning L, Honegger J, Hofmann M, Thimme R, Timm J; STOPHCV investigators; Schnitzler P, Merle U, Shoukry NH, Bruneau J, Rodrigo C, Lloyd A, Bull RA, Ansari MA, Mogler C, McLauchlan J, Forns X, Pérez-Del-Pulgar S, Lohmann V. Rothhaar P, et al. Nat Commun. 2025 Dec 7;16(1):10948. doi: 10.1038/s41467-025-67174-w. Nat Commun. 2025. PMID: 41354652 Free PMC article.
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Richard J, Grunst MW, Niu L, Díaz-Salinas MA, Zhu L, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Kim H, Boodapati SLT, Yang D, Chiu TJ, Chen HC, Benlarbi M, Beaudoin-Bussières G, Gottumukkala S, Li W, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB 3rd, Kumar P, Mothes W, Munro JB, Pazgier M, Finzi A. Richard J, et al. Nat Commun. 2025 Dec 1;16(1):10419. doi: 10.1038/s41467-025-65866-x. Nat Commun. 2025. PMID: 41326374 Free PMC article.
Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates.
Kowalewski J, Deutscher R, Richardoz M, Tomaszczyk M, Gelin M, Labesse G, Hausch F, Wright GD, Dunyach-Remy C, Guichou JF, Lionne C. Kowalewski J, et al. Commun Chem. 2025 Nov 27;8(1):417. doi: 10.1038/s42004-025-01795-6. Commun Chem. 2025. PMID: 41310159 Free PMC article.
According to the World Health Organization (WHO), antimicrobial resistance is a serious global health issue. Overcoming antibiotic resistance involves several strategies, including the inhibition of resistance mechanisms. ...
According to the World Health Organization (WHO), antimicrobial resistance is a serious global health issue. Overcoming antibi …
Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis.
LaRock DL, Sherman JD, Qu C, Ngai W, Read TD, McGavin MJ, LaRock CN. LaRock DL, et al. Nat Commun. 2025 Nov 26;16(1):10570. doi: 10.1038/s41467-025-65674-3. Nat Commun. 2025. PMID: 41298504 Free PMC article.
Staphylococcus aureus is a common colonizer of human skin, which, despite its ubiquitous nature, has a high virulence potential. Tolerating microbes in health but responding effectively to pathogens presents a challenge to the barrier tissues. ...
Staphylococcus aureus is a common colonizer of human skin, which, despite its ubiquitous nature, has a high virulence potential. Tolerating …
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.
Tjeerdsma RB, Ng TF, Roorda M, Bianchi D, Yang S, Bonnet C, VanInsberghe M, Everts M, Bakker FJ, de Boer HR, Moatti N, Hustedt N, Yin JZ, Hoeg L, Leibovitch M, Sicheri F, van Oudenaarden A, de Jong S, van den Berg J, Tanenbaum ME, Brummelkamp TR, Durocher D, van Vugt MATM. Tjeerdsma RB, et al. Nat Commun. 2025 Nov 24;16(1):11598. doi: 10.1038/s41467-025-66514-0. Nat Commun. 2025. PMID: 41285872 Free PMC article.
Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study.
Lee G, Wilk K, Chong C, Yeung J, Wheeler AL, Foster JA, Zhang TY, Lerch JP, Nieman BJ, Palmert MR. Lee G, et al. Transl Psychiatry. 2025 Nov 24;15(1):500. doi: 10.1038/s41398-025-03701-z. Transl Psychiatry. 2025. PMID: 41285717 Free PMC article.
Maternal diet and metabolic conditions, such as obesity and diabetes, are associated with consequences for offspring brain health, including effects on behaviour and an increased risk for neurodevelopmental disorders (NDDs). ...
Maternal diet and metabolic conditions, such as obesity and diabetes, are associated with consequences for offspring brain health, in …
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate.
Nguyen AA, Fisher L, Ahn JSY, Zuo M, Park T, Yadav A, Gams MS, Haniuda K, Dasoveanu DC, Li C, Ward LA, Wang AA, Tayyebi Z, Trofimova D, McKee T, Mendelsohn CL, Allingham JS, Guidos CJ, Maître B, Gommerman JL, Brown CC. Nguyen AA, et al. Nat Immunol. 2025 Dec;26(12):2159-2169. doi: 10.1038/s41590-025-02329-x. Epub 2025 Nov 21. Nat Immunol. 2025. PMID: 41272166
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Resnick SJ, Qamar S, Krishna P, Korobeynikov V, Ausserwoger H, Miller A, Esposito P, Varela JA, Sheng J, Huang LH, Nixon-Abell J, Melore S, Chung CW, Läubli NF, Kapsiani S, Li X, Wang J, Zhang N, Alam MM, Burguete AS, Swayne TC, Chen Y, Liao YC, Shneider NA, Vendruscolo M, Knowles TPJ, Kaminski CF, Ruggeri FS, Kaminski Schierle GS, St George-Hyslop P, Chavez A. Resnick SJ, et al. Nat Commun. 2025 Nov 21;16(1):10285. doi: 10.1038/s41467-025-65178-0. Nat Commun. 2025. PMID: 41271702 Free PMC article.
Neurodegenerative disorders (NDDs) are a family of diseases that remain poorly treated despite their growing global health burden. To gain insight into the mechanisms and modulators of neurodegeneration, we developed a yeast-based multiplex genetic screening platform. ...
Neurodegenerative disorders (NDDs) are a family of diseases that remain poorly treated despite their growing global health burden. To …
Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes.
Uusküla-Reimand L, Lee CA, Oh RH, Klein ZP, Adler N, Akhtar Alvi S, Langille E, Pasini E, Cheng KCL, Serafimova E, Abd-Rabbo D, Hou H, Tsai R, Bhat M, Schramek D, Wilson MD, Reimand J. Uusküla-Reimand L, et al. Nat Commun. 2025 Nov 21;16(1):10241. doi: 10.1038/s41467-025-65005-6. Nat Commun. 2025. PMID: 41271620 Free PMC article.
Our study highlights TOP2B as a safeguard of genome integrity and a marker of mutational processes and hotspots in cancer, underscoring implications for cancer genomics research....
Our study highlights TOP2B as a safeguard of genome integrity and a marker of mutational processes and hotspots in cancer, underscoring impl …
Quantifying the impact of early life growth adversity on later life health.
Goldman-Pham R, Alter MP, Bao R, Collins SÉ, Debban CL, Allinson JP, Ambler A, Bertoni AG, Caspi A, Lovinsky-Desir S, Ekstrom MP, Engert JC, Jacobs DR Jr, Malinsky D, Manichaikul A, Michos ED, Moffitt TE, Oelsner EC, Ramrakha S, Rich SS, Sack C, Stanojevic S, Subbarao P, Sugden K, Theodore R, Watson KE, Williams B, Yang B, Dupuis J, Shaheen SO, Barr RG, Hancox RJ, Smith BM. Goldman-Pham R, et al. Commun Med (Lond). 2025 Nov 17;5(1):534. doi: 10.1038/s43856-025-01245-3. Commun Med (Lond). 2025. PMID: 41258496 Free PMC article.
CONCLUSIONS: This study introduces a precision index of early-life growth adversity deployable in adulthood to investigate the developmental origins of longevity and improve health equity across the life course. Early-life exposures that adversely affect body growth have b …
CONCLUSIONS: This study introduces a precision index of early-life growth adversity deployable in adulthood to investigate the developmental …
Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy.
Xie K, Sahlas E, Ngo A, Chen J, Arafat T, Royer J, Zhou Y, Rodríguez-Cruces R, Dascal A, Caldairou B, Fadaie F, Barnett A, Audrain S, Larivière S, Caciagli L, Pana R, Weil AG, Grova C, Frauscher B, Schrader DV, Zhang Z, Concha L, Bernasconi A, Bernasconi N, Bernhardt BC. Xie K, et al. Nat Commun. 2025 Nov 19;16(1):10145. doi: 10.1038/s41467-025-65042-1. Nat Commun. 2025. PMID: 41258102 Free PMC article.
First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo.
Mukadi-Bamuleka D, Kinganda-Lusamaki E, Mulopo-Mukanya N, Amuri-Aziza A, O'Toole Á, Merritt S, Modadra-Madakpa B, Mutombo-Ndongala G, Vakaniaki EH, Kacita C, Maboko GL, Makangara-Cigolo JC, Ngimba M, Lokilo-Lofiko E, Pukuta-Simbu E, Luakanda-Ndelemo G, Bodisa-Matamu T, Paluku-Kalimuli Z, Akil-Bandali P, Kavira-Bapitani S, Jansen D, Kavira-Kamaliro A, Muhindo-Milonde E, Mufungizi J, Birindwa-Hamisi Y, Kavunga H, Tshiani O, Nundu SS, Liesenborghs L, Hoff NA, Halbrook M, Shongo R, Ayouba A, Pilarowski G, Mangolopa AK, Ebondo AK, Low N, Shaw SY, Wilkinson S, Tessema SK, Subissi L, Delaporte E, Vercauteren K, Wawina-Bokalanga T, Rimoin AW, Hensley LE, Peeters M, Loman N, Rambaut A, Muyembe-Tamfum JJ, Kindrachuk J, Mbala-Kingebeni P, Ahuka-Mundeke S. Mukadi-Bamuleka D, et al. Commun Med (Lond). 2025 Nov 15;5(1):496. doi: 10.1038/s43856-025-01203-z. Commun Med (Lond). 2025. PMID: 41258006 Free PMC article.
Clade Ib mpox virus (MPXV) emergence has heightened public health concern due to observed sustained human-human transmission and spread to multiple non-endemic East African countries. ...
Clade Ib mpox virus (MPXV) emergence has heightened public health concern due to observed sustained human-human transmission and spre …
Objective speech measures capture depressive symptoms and associated cognitive difficulties.
Wiseman M, Yep R, Wood Alexander M, Pople CB, Perri L, Gopinath G, Vasileiadi M, Robin J, Spilka MJ, Simpson W, Yunusova Y, Munoz DP, Coe BC, Brien D, Nestor S, Lipsman N, Giacobbe P, Rabin JS. Wiseman M, et al. Transl Psychiatry. 2025 Nov 17;15(1):525. doi: 10.1038/s41398-025-03728-2. Transl Psychiatry. 2025. PMID: 41257835 Free PMC article.
Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition.
Mirzaa GM, Yan K, Relator R, Levesque M, Jayasinghe P, Timpano S, Yalcin B, Collins S, Ziegler A, Pao E, Oyama N, Brischoux-Boucher E, Piard J, Monaghan KG, Guillen Sacoto MJ, Dobyns WB, Park KL, Fernández-Mayoralas DM, Fernández-Jaén A, Jayakar P, Palomares-Bralo M, Santos-Simarro F, Brusco A, Antona V, Giorgio E, Kvarnung M, Isidor B, Conrad S, Cogné B, Deb W, Stuurman KE, Štěrbová K, Smal N, Weckhuysen S, Oegema R, Innes AM, Koboldt DC, Ben-Omran T, Yeh RC, Kruer MC, Bakhtiari S, Papavasiliou A, Moutton S, Nambot S, Chanprasert S, Paolucci SA, Miller K, Burton B, Kim K, O'Heir E, Bruwer Z, Donald KA, Kleefstra T, Goldstein A, Angle B, Bontempo K, Miny P, Joset P, Demurger F, Hobson E, Pang L, Carpenter L, Li D, Bonneau D, Sadikovic B, Picketts DJ. Mirzaa GM, et al. Nat Commun. 2025 Nov 10;16(1):9875. doi: 10.1038/s41467-025-64838-5. Nat Commun. 2025. PMID: 41213919 Free PMC article.
Associations of neuromelanin in the substantia nigra with antipsychotic response in schizophrenia.
Tarumi R, Honda S, Cassidy C, Etani T, Homma S, Sekihara S, Kaneko Y, Moriyama S, Tobari Y, Takahashi K, Ueno F, Horga G, Tsugawa S, Rubio JM, Matsui M, Fujii S, Graff-Guerrero A, Noda Y, Uchida H, Nakajima S. Tarumi R, et al. Neuropsychopharmacology. 2026 Feb;51(3):682-690. doi: 10.1038/s41386-025-02275-0. Epub 2025 Nov 7. Neuropsychopharmacology. 2026. PMID: 41203946 Free article.
Since the dorsal SN contributes to both the mesolimbic and nigrostriatal pathways, with a relatively greater role in the former, dopamine functions in these pathways may play different roles for treatment responsiveness. Further research with multimodal imaging is needed t …
Since the dorsal SN contributes to both the mesolimbic and nigrostriatal pathways, with a relatively greater role in the former, dopamine fu …
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.
Ferrari-Souza JP, Povala G, Rahmouni N, Bellaver B, Ferreira PCL, De Bastiani MA, Leffa DT, Lussier FZ, Aguzzoli CS, Brum WS, Carello-Collar G, Borelli WV, Therriault J, Macedo AC, Servaes S, Stevenson J, Pola I, Gauthier S, Souza DO, Schilling LP, Lourenco MV, Triana-Baltzer G, Kolb HC, Benedet AL, Ashton NJ, Tudorascu DL, Zetterberg H, Blennow K, Johnson SC, Pascoal TA, Rosa-Neto P, Zimmer ER. Ferrari-Souza JP, et al. Nat Neurosci. 2026 Jan;29(1):81-87. doi: 10.1038/s41593-025-02103-0. Epub 2025 Nov 6. Nat Neurosci. 2026. PMID: 41198899 Free PMC article.
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.
Shuldiner EG, Karmakar S, Tsai MK, Hebert JD, Tang YJ, Andrejka L, Robertson MR, Wang M, Detrick CR, Cai H, Tang R, Kunder CA, Feldser DM, Petrov DA, Winslow MM. Shuldiner EG, et al. Nat Aging. 2025 Nov;5(11):2263-2278. doi: 10.1038/s43587-025-00986-z. Epub 2025 Nov 4. Nat Aging. 2025. PMID: 41188600 Free PMC article.
De novo variant analysis of childhood-onset obsessive-compulsive disorder in the French-Canadian population.
Bornais K, Ross JP, Schmilovich Z, Medeiros M, Castonguay CÉ, Spiegelman D, Boileau B, Marier JJ, Laurin G, Dion PA, Rouleau GA. Bornais K, et al. Transl Psychiatry. 2025 Oct 31;15(1):463. doi: 10.1038/s41398-025-03661-4. Transl Psychiatry. 2025. PMID: 41173879 Free PMC article.
Here, we aimed to investigate the impact of rare de novo single nucleotide variants (dnSNVs) on childhood-onset OCD risk in the French-Canadian population. In a cohort of 36 French-Canadian trios comprised of 36 probands with childhood-onset OCD and 72 unaffected pa …
Here, we aimed to investigate the impact of rare de novo single nucleotide variants (dnSNVs) on childhood-onset OCD risk in the French-Ca …
Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial.
Tie J, Wang Y, Loree JM, Cohen JD, Wong R, Price T, Tebbutt NC, Gebski V, Espinoza D, Burge M, Harris S, Lynam J, Lee B, Lee MM, Breadner D, Debrincat M, Foroughi S, Chantrill L, Lim SH, Gill S, O'Callaghan C, Ptak J, Silliman N, Dobbyn L, Popoli M, Bettegowda C, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P; AGITG DYNAMIC-III Study Group (Intergroup Study of the Australasian Gastro-Intestinal Trials Group and Canadian Cancer Trials Group). Tie J, et al. Nat Med. 2025 Dec;31(12):4291-4300. doi: 10.1038/s41591-025-04030-w. Epub 2025 Oct 20. Nat Med. 2025. PMID: 41115959 Clinical Trial.
Characterizing the physiology of circulatory arrest in humans.
Bird JD, Hornby L, Hirsch-Reinshagen V, Allen CP, Isac G, Gooderham PA, Shemie SD, Dhanani S, Thiara S, Stukas S, Grey R, Foster DA, Maier LE, LeBlanc AE, Kanji HD, Morelli TF, Agbay AM, Wellington CL, Chahal D, Belanger EC, Ren H, Mattu PS, Su S, Hrazdil CT, Percy J, Sangha P, Plewes LV, Sweet DD, Romano KR, Vu EN, Chittock DR, Dhingra VK, Henderson WR, Garraway NR, Morad Hameed S, Finlayson GN, MacLeod DB, Gibbons TD, Ainslie PN, Hoiland RL, Griesdale DE, Ronco JJ, Sekhon MS. Bird JD, et al. Nat Med. 2025 Oct;31(10):3542-3552. doi: 10.1038/s41591-025-03889-z. Epub 2025 Oct 16. Nat Med. 2025. PMID: 41102468 Free PMC article.
Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.
Watt K, Dauber B, Szkop KJ, Lee L, Jovanovic P, Chen S, Palia R, Vassalakis JA, Cooper TT, Papadopoli D, Masvidal L, Jewer M, Tandoc K, Plummer H, Lajoie GA, Topisirovic I, Larsson O, Postovit LM. Watt K, et al. Nat Cell Biol. 2025 Nov;27(11):1965-1981. doi: 10.1038/s41556-025-01786-8. Epub 2025 Oct 16. Nat Cell Biol. 2025. PMID: 41102449 Free PMC article.
EMito-Metrix enables automated evaluation of mitochondrial morphology across species.
Morin E, Doumard E, Hartnell LM, Salegi Ansa B, Leduc-Gaudet JP, Quillien A, Nakhle J, Ethuin S, Goudounèche D, Payré B, Soldan V, Balor S, Mattout A, Rouquette J, Dubois L, Sengenès C, Planat V, Casteilla L, Yart A, Dray C, Aligon J, Ferrucci L, Duchesne É, Hussain SNA, Gouspillou G, Formentini L, Mourier A, Baris OR, Valet P, Parpex H, Monsarrat P, Vigneau M, Pradère JP. Morin E, et al. Nat Metab. 2025 Nov;7(11):2179-2182. doi: 10.1038/s42255-025-01400-z. Nat Metab. 2025. PMID: 41094017 No abstract available.
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system.
Edwards K, Merrill SM, Konwar C, Jude MS, Zhuang BC, Meijer M, Navarro-Delgado E, MacIsaac JL, Mandhane P, Simons E, Moraes TJ, Azad MB, Subbarao P, Bustamante M, Vrijheid M, Turvey S, Kobor MS. Edwards K, et al. Commun Biol. 2025 Oct 9;8(1):1447. doi: 10.1038/s42003-025-08844-9. Commun Biol. 2025. PMID: 41068453 Free PMC article.
We explore immune associated DNA methylation (DNAm) changes in the context of age and sex leveraging whole blood samples collected at ages one and five from CHILD, a Canadian longitudinal pediatric cohort (n = 760: 356 female and 404 male). DNAm-based computational cell ty …
We explore immune associated DNA methylation (DNAm) changes in the context of age and sex leveraging whole blood samples collected at ages o …
Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
Vanderperre B, Muraleedharan A, Dorion MF, Larroquette F, Del Cid Pellitero E, Rajakulendran N, Chen CX, Larivière R, Michaud-Tardif C, Goiran T, Chidiac R, Lipuma D, MacLeod G, Thomas R, Wang Z, Reintsch WE, Luo W, Shlaifer I, Zhang F, Xia K, Steinhart Z, Linhardt RJ, Trempe JF, Liu J, Durcan TM, Angers S, Fon EA. Vanderperre B, et al. Commun Biol. 2025 Oct 6;8(1):1426. doi: 10.1038/s42003-025-08786-2. Commun Biol. 2025. PMID: 41053297 Free PMC article.
Early pandemic HIV-1 integration site preferences differ across anatomical sites.
Kohio HP, Ajoge HO, Barua EA, Vajaria NR, Wu IKF, Coleman MD, Tom SK, van der Meer F, Gill J, Church D, Beck P, Power C, van Marle G, Barr SD. Kohio HP, et al. Commun Med (Lond). 2025 Oct 6;5(1):405. doi: 10.1038/s43856-025-01146-5. Commun Med (Lond). 2025. PMID: 41053231 Free PMC article.
This makes it hard to completely remove the virus, even with strong treatment. In this study, researchers explored whether HIV hides in different ways depending on where in the body the infected cells are found. ...
This makes it hard to completely remove the virus, even with strong treatment. In this study, researchers explored whether HIV hides …
The antioxidant N-acetylcysteine prevents cortical neuropathological phenotypes caused by adolescent Δ-9-tetrahydrocannabinol exposure in male rats.
Szkudlarek HJ, Singh Mann R, Wieczerzak K, Sarikahya MH, Uzuneser TC, De Felice M, Rodríguez-Ruiz M, Galindo JP, Pusparajah M, Whitehead SN, Rushlow WJ, Hardy DB, Schmid S, Yeung KK, Laviolette SR. Szkudlarek HJ, et al. Transl Psychiatry. 2025 Oct 6;15(1):374. doi: 10.1038/s41398-025-03580-4. Transl Psychiatry. 2025. PMID: 41052996 Free PMC article.
HippoMaps: multiscale cartography of human hippocampal organization.
DeKraker J, Cabalo DG, Royer J, Ngo A, Khan AR, Karat BG, Benkarim O, Rodriguez-Cruces R, Frauscher B, Pana R, Hansen JY, Misic B, Valk SL, Lau JC, Kirschner M, Bernasconi A, Bernasconi N, Muenzing SEA, Axer M, Amunts K, Evans AC, Bernhardt BC. DeKraker J, et al. Nat Methods. 2025 Oct;22(10):2211-2222. doi: 10.1038/s41592-025-02783-3. Epub 2025 Oct 1. Nat Methods. 2025. PMID: 41034610 Free PMC article.
These features make the hippocampus a model to understand how brain structure covaries with function, in both health and disease. Here we introduce HippoMaps, an open access toolbox and online data warehouse for the mapping and contextualization of subregional hippocampal …
These features make the hippocampus a model to understand how brain structure covaries with function, in both health and disease. Her …
A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric low-grade glioma.
Andrade AF, Sigaud R, Puligandla E, Liu B, Karimi E, Annett A, Rezanejad M, Jawhar W, Taylor R, Cao Y, Schmid S, Selt F, Hernáiz Driever P, Horn S, Sievers P, Prinz M, Glatzel M, Mawrin C, Hartmann C, Monoranu CM, Konnikova L, Sahm F, Pfister SM, Witt O, Jones DTW, Koch A, Kleinman CL, Capper D, Walsh L, Jabado N, Milde T. Andrade AF, et al. Nat Immunol. 2025 Oct;26(10):1794-1806. doi: 10.1038/s41590-025-02268-7. Epub 2025 Sep 15. Nat Immunol. 2025. PMID: 40954250
Detecting suicide risk in bipolar disorder patients from lymphoblastoid cell lines genetic signatures.
Sharma O, Nayak R, Mizrahi L, Rike WA, Choudhary A, Sadis H, Hussein Y, Rosh I, Tripathi U, Shemen A, Stern Y, Squassina A, Alda M, Stern S. Sharma O, et al. Transl Psychiatry. 2025 Sep 3;15(1):339. doi: 10.1038/s41398-025-03573-3. Transl Psychiatry. 2025. PMID: 40903457 Free PMC article.
This research aimed to develop a machine learning algorithm to predict suicide risk in bipolar disorder (BD) patients using RNA sequencing analysis of lymphoblastoid cell lines (LCLs). ...
This research aimed to develop a machine learning algorithm to predict suicide risk in bipolar disorder (BD) patients using RNA seque …
Lasting effects of oral contraceptives on fear responses to a safe context.
Davignon LM, Brouillard A, Marin MF. Davignon LM, et al. Neuropsychopharmacology. 2026 Jan;51(2):401-411. doi: 10.1038/s41386-025-02208-x. Epub 2025 Aug 30. Neuropsychopharmacology. 2026. PMID: 40885850 Free article.
While prior human studies focused on cue-related extinction recall, animal research suggests that a single high-dose of exogenous E2 generalizes fear to safe contexts. ...
While prior human studies focused on cue-related extinction recall, animal research suggests that a single high-dose of exogenous E2 …
Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development.
Fernandes CFL, Lopes MH, Souza MCDS, Soares SR, Arévalo-Romero JA, Lackie RE, Coelho BP, de Araújo JPA, Boccacino JM, Iglesia RP, Melo-Escobar MI, Prado MB, Falchetti M, Ferreira FM, Nakaya H, Dos Santos TG, da Rocha EL, Beraldo FH, Prado VF, Prado MAM. Fernandes CFL, et al. Commun Biol. 2025 Aug 29;8(1):1302. doi: 10.1038/s42003-025-08763-9. Commun Biol. 2025. PMID: 40883424 Free PMC article.
Enzyme-mediated aminoglycoside resistance without target mimicry.
Hemmings M, Zieliński M, Golkar T, Blanchet J, Pistofidis A, Munro K, Schmeing TM, Bohle DS, Berghuis AM. Hemmings M, et al. Commun Chem. 2025 Aug 25;8(1):258. doi: 10.1038/s42004-025-01666-0. Commun Chem. 2025. PMID: 40855189 Free PMC article.
REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate.
Sahinyan K, Blackburn DM, Simon MM, Lazure F, Kwan T, Wilson DH, Vahidyeganeh M, Alsadi N, von Maltzahn J, Yamada Y, Jahani-Asl A, Bourque G, Rudnicki MA, Soleimani VD. Sahinyan K, et al. Nat Commun. 2025 Aug 12;16(1):7487. doi: 10.1038/s41467-025-62758-y. Nat Commun. 2025. PMID: 40796549 Free PMC article.
Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library.
Chen X, Koteva K, Chou S, Guitor A, Pallant D, Lee Y, Sychantha D, French S, Hackenberger D, Robbins N, Cook MA, Brown ED, MacNeil LT, Cowen LE, Wright GD. Chen X, et al. Nat Commun. 2025 Aug 8;16(1):7337. doi: 10.1038/s41467-025-62630-z. Nat Commun. 2025. PMID: 40781075 Free PMC article.
Coniotins exhibits potent activity against critical priority fungal pathogens listed by the World Health Organization, including C. albicans, Cryptococcus neoformans, multidrug-resistant Candida auris, and Aspergillus fumigatus, with high selectivity and low resistance pot …
Coniotins exhibits potent activity against critical priority fungal pathogens listed by the World Health Organization, including C. a …
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression.
Chawla A, Cakmakci D, Fiori LM, Zang W, Maitra M, Yang J, Żurawek D, Frosi G, Rahimian R, Mitsuhashi H, Davoli MA, Denniston R, Chen GG, Yerko V, Mash D, Girdhar K, Akbarian S, Mechawar N, Suderman M, Li Y, Nagy C, Turecki G. Chawla A, et al. Nat Genet. 2025 Aug;57(8):1890-1904. doi: 10.1038/s41588-025-02249-4. Epub 2025 Aug 5. Nat Genet. 2025. PMID: 40764843
Intracrine FFA4 signaling controls lipolysis at lipid droplets.
O'Brien SL, Tripp E, Barki N, Blondel-Tepaz E, Smith G, Boufersaoui A, Roberts J, Pike JA, Correia J, Miljus T, Bouvier M, Tennant DA, Hudson BD, Gerhart-Hines Z, Milligan G, Schwartz TW, Calebiro D. O'Brien SL, et al. Nat Chem Biol. 2026 Jan;22(1):109-119. doi: 10.1038/s41589-025-01982-5. Epub 2025 Aug 5. Nat Chem Biol. 2026. PMID: 40764678 Free PMC article.
Network spreading and local biological vulnerability in amyotrophic lateral sclerosis.
Farahani A, Hansen JY, Bazinet V, Shafiei G, Collins DL, Dadar M, Kalra S, Dagher A, Misic B. Farahani A, et al. Commun Biol. 2025 Aug 4;8(1):1153. doi: 10.1038/s42003-025-08561-3. Commun Biol. 2025. PMID: 40760014 Free PMC article.
Here, we investigate how network structure and local biological features shape the spatial patterning of atrophy in ALS. We analyze the Canadian ALS Neuroimaging Consortium (CALSNIC) dataset and estimate cortical atrophy using deformation based morphometry (DBM). ...
Here, we investigate how network structure and local biological features shape the spatial patterning of atrophy in ALS. We analyze the C …
Mechanistic insights into 16p13.3 microdeletions encompassing TBC1D24 and ATP6V0C through advanced sequencing approaches.
Mazel B, Coleman EA, Rousseau J, Kailasam S, Ajeawung NF, Jimenez Cruz DA, Ehresmann S, Chen G, Ernst C, Campeau PM. Mazel B, et al. Eur J Hum Genet. 2025 Sep;33(9):1136-1143. doi: 10.1038/s41431-025-01912-y. Epub 2025 Jul 28. Eur J Hum Genet. 2025. PMID: 40721525
Microhomology-mediated end-joining and non-homologous end-joining emerged as other mechanisms driving these 16p13.3 microdeletions, which differs from other studied contiguous gene deletion syndromes. This research contributes to a deeper understanding of microdeletion-ass …
Microhomology-mediated end-joining and non-homologous end-joining emerged as other mechanisms driving these 16p13.3 microdeletions, which di …
Somites are a source of nephron progenitors in zebrafish.
Peng Z, Vanichapol T, Nguyen PD, Chang HG, Kocha KM, O'Brien LL, Currie PD, Huang P, Davidson AJ. Peng Z, et al. Nat Commun. 2025 Jul 26;16(1):6914. doi: 10.1038/s41467-025-62259-y. Nat Commun. 2025. PMID: 40715167 Free PMC article.
Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population.
Ficorella L, Yang X, Mavaddat N, Carver T, Hassan H, Dennis J, Tyrer J, Ho WK, Teo SH, Hartman M, Li J, Eriksson M, Czene K, Hall P, Rahman T, Bacon A, Hardy S, Stokes AE, Stutzin Donoso F, Archer S, Simard J, Pharoah PDP, Usher-Smith JA, Tischkowitz M, Easton DF, Antoniou AC. Ficorella L, et al. Br J Cancer. 2025 Oct;133(6):844-855. doi: 10.1038/s41416-025-03117-y. Epub 2025 Jul 17. Br J Cancer. 2025. PMID: 40676226 Free PMC article.
Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis.
McDonald PC, Topham JT, Awrey S, Tavakoli H, Carroll R, Brown WS, Gerbec ZJ, Kalloger SE, Karasinska JM, Tang P, Goodwin R, Jones SJM, Laskin J, Marra MA, Morin GB, Renouf DJ, Schaeffer DF, Dedhar S. McDonald PC, et al. Commun Biol. 2025 Jul 4;8(1):1006. doi: 10.1038/s42003-025-08440-x. Commun Biol. 2025. PMID: 40615661 Free PMC article.
Transglutaminase 2 function in glioblastoma tumor efferocytosis.
Lui M, Sevinc F, Elgafarawi M, Munoz DG, Keillor JW, Sinclair J, Catana D, Alhuthayl M, Woulfe J, Lorimer IA. Lui M, et al. Cell Death Dis. 2025 Jul 3;16(1):487. doi: 10.1038/s41419-025-07819-2. Cell Death Dis. 2025. PMID: 40610434 Free PMC article.
Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP.
Knodel S, Main L, DeLeon M, Lamont A, Edward J, Gupta AK, Noel-Romas L, Mohammed S, Tattersall T, Wong J, Hull M, Grennan T, Burgener AD. Knodel S, et al. Nat Commun. 2025 Jul 3;16(1):6143. doi: 10.1038/s41467-025-61426-5. Nat Commun. 2025. PMID: 40610420 Free PMC article. Clinical Trial.
This study shows doxyPrEP use results in minimal compositional changes in the microbiome over 12 months. Further research is needed to explore the impact of doxycycline for STI prevention on microbiome function and antimicrobial resistance....
This study shows doxyPrEP use results in minimal compositional changes in the microbiome over 12 months. Further research is needed t …
O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis.
Ahmed O, Masclef L, Iannantuono N, Gagnon J, Gushul-Leclaire M, Boulay K, Estavoyer B, Echbicheb M, Ali Boubacar K, Poy M, Boubekeur A, Menggad S, Schcolnik-Cabrera A, Balsalobre A, Bonneil E, Thibault P, Hulea L, Mallette FA, Drouin J, Tanaka Y, Affar EB. Ahmed O, et al. Nat Commun. 2025 Jul 1;16(1):5959. doi: 10.1038/s41467-025-61022-7. Nat Commun. 2025. PMID: 40593803 Free PMC article.
Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.
Broderick K, Moutaoufik MT, Saccon T, Malty R, Amin S, Phanse S, Joseph TP, Zilocchi M, Hosseinnia A, Istace Z, Hajikarimlou M, Abrar S, Fisher J, Brassard R, Perera R, Kumar A, Aoki H, Rahmatbakhsh M, Jessulat M, Kobasa D, Dehne F, Prasad B, Gagarinova A, Joanne Lemieux M, Cochrane A, Houry WA, Aly KA, Golshani A, Babu M. Broderick K, et al. Nat Commun. 2025 Jul 1;16(1):5784. doi: 10.1038/s41467-025-60949-1. Nat Commun. 2025. PMID: 40593736 Free PMC article.
Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions.
Manikpurage HD, Bourgault J, Houessou U, Paulin A, Zamani P, Gagnon E, Li Z, Boudreau DK, Eslami A, Voisine P, Mathieu P, Bossé Y, Arsenault BJ, Thériault S. Manikpurage HD, et al. Commun Med (Lond). 2025 Jul 1;5(1):264. doi: 10.1038/s43856-025-00981-w. Commun Med (Lond). 2025. PMID: 40593158 Free PMC article.
METHODS: We validated previously reported CAD-PRS and 6 cardiovascular (CV) risk factors PRS (systolic blood pressure [SBP], type 2 diabetes [T2D], body-mass index [BMI], low-density lipoprotein cholesterol [LDL], triglycerides [TG], and lipoprotein-[a][Lp(a)]) in individuals of …
METHODS: We validated previously reported CAD-PRS and 6 cardiovascular (CV) risk factors PRS (systolic blood pressure [SBP], type 2 diabetes …
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion.
Dahabieh MS, DeCamp LM, Oswald BM, Kitchen-Goosen SM, Fu Z, Vos M, Compton SE, Longo J, Foy NM, Williams KS, Ellis AE, Johnson A, Sodiya I, Vincent M, Lee H, Yao C, Wu T, Sheldon RD, Krawczyk CM, Jones RG. Dahabieh MS, et al. Nat Immunol. 2025 Jul;26(7):1139-1151. doi: 10.1038/s41590-025-02185-9. Epub 2025 Jun 27. Nat Immunol. 2025. PMID: 40579556 Free PMC article.
Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy.
Cagnone G, Pundir S, Betus C, Agnihotri T, Ren A, -Kim JS, Harvey NR, Heckel E, Chen MX, Situ A, Gaub P, Kim N, Das A, Leclerc S, Wünnemann F, Berillon L, Andelfinger G, Crespo-Garcia S, Dubrac A, Rezende FA, Clish CB, Maranda B, Rivera JC, Smith LEH, Sapieha P, Joyal JS. Cagnone G, et al. Nat Commun. 2025 Jun 25;16(1):5377. doi: 10.1038/s41467-025-60061-4. Nat Commun. 2025. PMID: 40562775 Free PMC article.
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases.
Zheng Y, Schupp JC, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer LJ, Rosas IO, Pineda R, Sembrat J, Königshoff M, McDonough JE, Vanaudenaerde BM, Wuyts WA, Kaminski N, Ding J. Zheng Y, et al. Nat Biomed Eng. 2025 Dec;9(12):2155-2180. doi: 10.1038/s41551-025-01423-7. Epub 2025 Jun 20. Nat Biomed Eng. 2025. PMID: 40542107 Free PMC article.
Relationship between grammar and schizophrenia: a systematic review and meta-analysis.
Elleuch D, Chen Y, Luo Q, Palaniyappan L. Elleuch D, et al. Commun Med (Lond). 2025 Jun 16;5(1):235. doi: 10.1038/s43856-025-00944-1. Commun Med (Lond). 2025. PMID: 40523895 Free PMC article.
Such communication difficulties may arise from deficits in syntax-understanding and generating grammatical structures. Research on syntactic impairments in schizophrenia is underpowered, with inconsistent findings, and it is unclear if deficits are specific to certain pati …
Such communication difficulties may arise from deficits in syntax-understanding and generating grammatical structures. Research on sy …
Trends in contralateral breast cancer and contralateral prophylactic mastectomy from 2009 to 2016.
Kim SJ, Arneja J, Christensen RAG, Anderson GM, Brooks JD. Kim SJ, et al. NPJ Breast Cancer. 2025 Jun 14;11(1):55. doi: 10.1038/s41523-025-00763-6. NPJ Breast Cancer. 2025. PMID: 40517156 Free PMC article.
This study characterizes trends in contralateral breast cancer (CBC) and contralateral prophylactic mastectomy (CPM) in Ontario, Canada, by breast cancer risk level. Overall, there has been a decline in CBC rates and the concomitant rise in CPM rates after unilateral breas …
This study characterizes trends in contralateral breast cancer (CBC) and contralateral prophylactic mastectomy (CPM) in Ontario, Canada …
The brain works at more than 10 bits per second.
Sauerbrei BA, Pruszynski JA. Sauerbrei BA, et al. Nat Neurosci. 2025 Jul;28(7):1365-1366. doi: 10.1038/s41593-025-01997-0. Nat Neurosci. 2025. PMID: 40514587 Free PMC article.
Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.
Shi R, Farnsworth DA, Febres-Aldana CA, Chow JLM, Sheena R, Atwal T, Gomez Marti JL, Li S, Thomas KN, Lee CM, Awrey SJ, McDonald PC, Somwar R, Dedhar S, Ladanyi M, Bennewith KL, Lockwood WW. Shi R, et al. Oncogene. 2025 Aug;44(32):2831-2849. doi: 10.1038/s41388-025-03461-6. Epub 2025 May 31. Oncogene. 2025. PMID: 40450112 Free PMC article.
A One Health approach to understanding and managing Nipah virus outbreaks.
Yadav PD, Baid K, Patil DY, Shirin T, Rahman MZ, Peel AJ, Epstein JH, Montgomery JM, Plowright RK, Salje H, Gurley ES, Satter SM, Banerjee A. Yadav PD, et al. Nat Microbiol. 2025 Jun;10(6):1272-1281. doi: 10.1038/s41564-025-02020-9. Epub 2025 May 28. Nat Microbiol. 2025. PMID: 40437297 Review.
Here, we review the pathways of NiV spillover and transmission, highlighting areas needing further research. We emphasize the importance of collaborative and multidisciplinary efforts both in the laboratory and in the field, and the implementation of a One Health st …
Here, we review the pathways of NiV spillover and transmission, highlighting areas needing further research. We emphasize the importa …
Tegavivint triggers TECR-dependent nonapoptotic cancer cell death.
Leak L, Wang Z, Joseph AJ, Johnson B, Chan AA, Decosto CM, Magtanong L, Ko PJ, Lee WC, Ritho J, Manukian S, Millner A, Chitkara S, Salinas JJ, Skouta R, Rees MG, Ronan MM, Roth JA, Myers CL, Moffat J, Boone C, Bensinger SJ, Nathanson DA, Atilla-Gokcumen GE, Moding EJ, Dixon SJ. Leak L, et al. Nat Chem Biol. 2025 Dec;21(12):1873-1884. doi: 10.1038/s41589-025-01913-4. Epub 2025 May 26. Nat Chem Biol. 2025. PMID: 40419770
Impact of unequal testing on vaccine effectiveness estimates across two study designs: a simulation study.
Bodner K, Wang L, Kustra R, Kwong JC, Sander B, Sbihi H, Irvine MA, Mishra S. Bodner K, et al. Nat Commun. 2025 May 24;16(1):4849. doi: 10.1038/s41467-025-59768-1. Nat Commun. 2025. PMID: 40413178 Free PMC article.
Observational studies are essential for measuring vaccine effectiveness. Recent research has raised concerns about how a relationship between testing and vaccination may affect estimates of vaccine effectiveness against symptomatic infection (symptomatic VE). ...
Observational studies are essential for measuring vaccine effectiveness. Recent research has raised concerns about how a relationship …
Integrating optical neuroscience tools into touchscreen operant systems.
Piantadosi PT, Princz-Lebel O, Skirzewski M, Dumont JR, Palmer D, Memar S, Saksida LM, Prado VF, Prado MAM, Bussey TJ, Holmes A. Piantadosi PT, et al. Nat Protoc. 2025 Sep;20(9):2418-2452. doi: 10.1038/s41596-025-01143-x. Epub 2025 May 23. Nat Protoc. 2025. PMID: 40410621 Free PMC article. Review.
Here we provide guidance and procedural descriptions to enable researchers to integrate optically based manipulation and measurement techniques into their touchscreen experimental systems. ...
Here we provide guidance and procedural descriptions to enable researchers to integrate optically based manipulation and measurement …
Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.
Yousefpour N, Tansley SN, Locke S, Sharif B, Parisien M, Bourojeni FB, Deamond H, Mathur V, Arana NR, Austin JS, Bourassa V, Wang C, Cabana VC, Wong C, Lister KC, Rodrigues R, St-Louis M, Paquet ME, Carroll MC, Andrews-Zwilling Y, Seguela P, Kania A, Yednock T, Mogil JS, De Koninck Y, Diatchenko L, Khoutorsky A, Ribeiro-da-Silva A. Yousefpour N, et al. Nat Commun. 2025 May 17;16(1):4590. doi: 10.1038/s41467-025-59849-1. Nat Commun. 2025. PMID: 40382320 Free PMC article.
Biological markers and psychosocial factors predict chronic pain conditions.
Fillingim M, Tanguay-Sabourin C, Parisien M, Zare A, Guglietti GV, Norman J, Petre B, Bortsov A, Ware M, Perez J, Roy M, Diatchenko L, Vachon-Presseau E. Fillingim M, et al. Nat Hum Behav. 2025 Aug;9(8):1710-1725. doi: 10.1038/s41562-025-02156-y. Epub 2025 May 12. Nat Hum Behav. 2025. PMID: 40355673 Free PMC article.
A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis.
Bennett J, Levine AB, Nobre L, Negm L, Chung J, Fang K, Johnson M, Komosa M, Krumholtz S, Nunes NM, Rana M, Ryall S, Sheth J, Siddaway R, Bale TA, Bouffet E, Cusimano MD, Das S, Detsky J, Dirks P, Karajannis MA, Kongkham P, Giantini-Larsen A, Li BK, Lim-Fat MJ, Lin AL, Mason WP, Miller A, Perry JR, Sahgal A, Sait SF, Tsang DS, Zadeh G, Laperriere N, Nguyen L, Gao A, Keith J, Munoz DG, Tabori U, Hawkins C. Bennett J, et al. Nat Cancer. 2025 Jun;6(6):1102-1119. doi: 10.1038/s43018-025-00962-x. Epub 2025 May 7. Nat Cancer. 2025. PMID: 40335748
Liposomal lipid nanoparticles for extrahepatic delivery of mRNA.
Cheng MHY, Zhang Y, Fox K, Leung J, Strong C, Kang E, Chen Y, Tong M, Bommadevara H, Jan E, Ip OYL, Rodríguez-Rodríguez C, Saatchi K, Häfeli UO, Abdolahzadeh A, Witzigmann D, Cullis PR. Cheng MHY, et al. Nat Commun. 2025 May 3;16(1):4135. doi: 10.1038/s41467-025-58523-w. Nat Commun. 2025. PMID: 40319025 Free PMC article.
A heme-dependent enzyme forms the hydrazine in the antibiotic negamycin.
Wang M, Wei ZW, Ryan KS. Wang M, et al. Nat Chem Biol. 2025 Jul;21(7):1012-1020. doi: 10.1038/s41589-025-01898-0. Epub 2025 May 1. Nat Chem Biol. 2025. PMID: 40312596
Additionally, the unique readthrough-promoting activity makes it a subject for research as a potential therapeutic agent for Duchenne muscular dystrophy and other hereditary diseases. ...
Additionally, the unique readthrough-promoting activity makes it a subject for research as a potential therapeutic agent for Duchenne …
A novel role for Neurog2 in MYCN driven neuroendocrine plasticity of prostate cancer.
Walke P, Price JDW, Vizeacoumar FS, Joseph N, Maranda V, Chowdhury B, Patel J, Zhang Y, Dong H, New L, Ganapathysamy A, Gong LH, Lazell-Wright M, Elhasasna H, Bhanumathy KK, Wu Y, Wang Y, Freywald A, Krishnan A, Vizeacoumar FJ. Walke P, et al. Oncogene. 2025 Aug;44(29):2460-2473. doi: 10.1038/s41388-025-03413-0. Epub 2025 Apr 29. Oncogene. 2025. PMID: 40301542 Free PMC article.
Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma.
Akuma M, Kim M, Zhu C, Wiljer E, Gaudreau-Lapierre A, Patterson LD, Egevad L, Tanguay S, Trinkle-Mulcahy L, Stanford WL, Riazalhosseini Y, Russell RC. Akuma M, et al. Cell Death Dis. 2025 Apr 16;16(1):307. doi: 10.1038/s41419-025-07623-y. Cell Death Dis. 2025. PMID: 40240354 Free PMC article.
Genetic modulation of brain dynamics in neurodevelopmental disorders: the impact of copy number variations on resting-state EEG.
Dubois AEE, Audet-Duchesne E, Knoth IS, Martin CO, Jizi K, Tamer P, Younis N, Jacquemont S, Dumas G, Lippé S. Dubois AEE, et al. Transl Psychiatry. 2025 Apr 11;15(1):139. doi: 10.1038/s41398-025-03324-4. Transl Psychiatry. 2025. PMID: 40216767 Free PMC article.
Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophrenia). ...
Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, sch …
Far-red fluorescent genetically encoded calcium ion indicators.
Dalangin R, Jia BZ, Qi Y, Aggarwal A, Sakoi K, Drobizhev M, Molina RS, Patel R, Abdelfattah AS, Zheng J, Reep D, Hasseman JP; GENIE Project Team; Zhao Y, Wu J, Podgorski K, Tebo AG, Schreiter ER, Hughes TE, Terai T, Paquet ME, Megason SG, Cohen AE, Shen Y, Campbell RE. Dalangin R, et al. Nat Commun. 2025 Apr 7;16(1):3318. doi: 10.1038/s41467-025-58485-z. Nat Commun. 2025. PMID: 40195305 Free PMC article.
The guinea pig serves as an alternative model to study human preimplantation development.
Canizo JR, Zhao C, Petropoulos S. Canizo JR, et al. Nat Cell Biol. 2025 Apr;27(4):696-710. doi: 10.1038/s41556-025-01642-9. Epub 2025 Apr 4. Nat Cell Biol. 2025. PMID: 40185949 Free PMC article.
The guinea pig serves as a valuable animal model for advancing preimplantation development and stem cell research, and can be leveraged to better understand the longer-term impact of early exposures on offspring outcomes....
The guinea pig serves as a valuable animal model for advancing preimplantation development and stem cell research, and can be leverag …
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